sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4ira | FAD | 4-hydroxyphenylacetate 3-monooxygenase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4ira | FAD | 4-hydroxyphenylacetate 3-monooxygenase | / | 1.000 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.543 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.536 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.518 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.509 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.504 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.504 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.502 | |
| 4xz3 | COA | Acyl-CoA synthetase (NDP forming) | / | 0.502 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.500 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.500 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.499 | |
| 1eio | GCH | Gastrotropin | / | 0.498 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.496 | |
| 3c1o | NAP | Eugenol synthase | / | 0.494 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.494 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.493 | |
| 1guy | NAD | Malate dehydrogenase | / | 0.493 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.493 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.492 | |
| 4g2g | TDH | Mycocyclosin synthase | 1.14.21.9 | 0.492 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.492 | |
| 3i6q | NDP | Putative leucoanthocyanidin reductase 1 | / | 0.488 | |
| 4x5h | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.487 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.487 | |
| 4k0t | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.487 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.486 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.486 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.486 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.486 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.486 | |
| 3w78 | CBD | FMN-dependent NADH-azoreductase | / | 0.486 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.486 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.486 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.486 | |
| 3eku | CY9 | Actin-5C | / | 0.485 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.485 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.485 | |
| 1u4o | NDD | L-lactate dehydrogenase | 1.1.1.27 | 0.484 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.483 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.483 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.483 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.483 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.483 | |
| 3eks | CY9 | Actin-5C | / | 0.483 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.483 | |
| 3i6i | NDP | Putative leucoanthocyanidin reductase 1 | / | 0.483 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.483 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.482 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.482 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.482 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.482 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.482 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.481 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.481 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.481 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.481 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.481 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.481 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.480 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.480 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.480 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.480 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.480 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.480 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.479 | |
| 2bxq | IMN | Serum albumin | / | 0.479 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.479 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.479 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.479 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.479 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.478 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.478 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.478 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.477 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.477 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.477 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.477 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.477 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.477 | |
| 4e2b | FMN | Dehydrogenase | / | 0.477 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.477 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.477 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.476 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.476 | |
| 3djf | BC3 | Purine nucleoside phosphorylase | / | 0.476 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.476 | |
| 3ie3 | N11 | Glutathione S-transferase P | 2.5.1.18 | 0.476 | |
| 4l8u | 9AZ | Serum albumin | / | 0.476 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.476 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.475 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.475 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.475 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.475 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.475 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.475 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.475 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.474 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.474 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.474 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.474 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.474 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.473 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.473 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.473 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.473 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.473 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.473 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.473 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.473 | |
| 3zhq | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.473 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 1j0x | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.472 | |
| 1n3r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.472 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.472 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.472 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.472 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.472 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.472 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.471 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.471 | |
| 1pyd | TDP | Pyruvate decarboxylase isozyme 1 | / | 0.471 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.470 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.470 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.470 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.470 | |
| 2p9c | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.470 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.470 | |
| 3e8x | NAP | BH1520 protein | / | 0.470 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.470 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.470 | |
| 3zs7 | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.470 | |
| 5l3d | FAD | Lysine-specific histone demethylase 1A | 1 | 0.470 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.469 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.469 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1gw2 | FER | Peroxidase C1A | 1.11.1.7 | 0.469 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.469 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.469 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.469 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.469 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.469 | |
| 3mkn | DNB | Pyrimidine-specific ribonucleoside hydrolase RihB | / | 0.469 | |
| 3zhr | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.469 | |
| 4eue | NAI | Trans-2-enoyl-CoA reductase [NADH] | / | 0.469 | |
| 4h6p | FMN | Chromate reductase | / | 0.469 | |
| 2rh1 | CAU | Beta-2 adrenergic receptor | / | 0.469 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.468 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.468 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.468 | |
| 1svl | ADP | Large T antigen | 3.6.4 | 0.468 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.468 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.468 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.468 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.468 | |
| 3ewk | FAD | Sensory box histidine kinase/response regulator | / | 0.468 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.468 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.468 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.468 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.468 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.468 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.468 | |
| 4rvn | COA | Phenylacetate-coenzyme A ligase | / | 0.468 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.468 | |
| 5il1 | SAM | N6-adenosine-methyltransferase 70 kDa subunit | / | 0.468 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.467 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.467 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.467 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.467 | |
| 2a84 | ATP | Pantothenate synthetase | 6.3.2.1 | 0.467 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.467 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.467 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.467 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.467 | |
| 2wd8 | VGF | Pteridine reductase | / | 0.467 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.467 | |
| 3cos | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.467 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.467 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.467 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.467 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.467 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.467 | |
| 4b67 | NAP | L-ornithine N(5)-monooxygenase | / | 0.467 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.467 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.467 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.467 | |
| 4xym | COA | Acyl-CoA synthetase (NDP forming) | / | 0.467 | |
| 1e3l | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.466 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.466 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.466 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.466 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.466 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.466 | |
| 5kf1 | COA | Predicted acetyltransferase | / | 0.466 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.465 | |
| 2xvw | 9NR | Serum albumin | / | 0.465 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.465 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.465 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.465 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 4l9q | 9TP | Serum albumin | / | 0.465 | |
| 4nvk | 2NY | Peroxidase | / | 0.465 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.464 | |
| 1jra | FAD | FAD-linked sulfhydryl oxidase ERV2 | 1.8.3.2 | 0.464 | |
| 1o5g | CR9 | Prothrombin | 3.4.21.5 | 0.464 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.464 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.464 | |
| 2gnh | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.464 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.464 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2vna | NAP | Prostaglandin reductase 2 | 1.3.1.48 | 0.464 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.464 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.464 | |
| 3nyr | MLC | Putative fatty acid synthase | / | 0.464 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.464 | |
| 3up5 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.464 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.464 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 4kug | NAD | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.464 | |
| 4rtb | SAM | Putative thiazole biosynthesis protein ThiH | / | 0.464 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.464 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.463 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.463 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.463 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.463 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.463 | |
| 2huq | SAH | Diphthine synthase | / | 0.463 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.463 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.463 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.463 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.463 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.463 | |
| 3w2f | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.463 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 4a61 | ANP | Plasmid segregation protein ParM | / | 0.463 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.463 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.463 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.463 | |
| 4fk8 | FAD | Ferredoxin--NADP reductase | / | 0.463 | |
| 4oe4 | NAD | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | 1.2.1.88 | 0.463 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.462 | |
| 2b69 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.462 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.462 | |
| 2p6l | SAH | Diphthine synthase | / | 0.462 | |
| 2zre | AGS | Protein RecA | / | 0.462 | |
| 3b9l | AZZ | Serum albumin | / | 0.462 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.462 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.462 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.462 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 3oxf | SAH | Histone-lysine N-methyltransferase SMYD3 | 2.1.1.43 | 0.462 | |
| 3p0h | FSE | Putative tyrosyl-tRNA synthetase | / | 0.462 | |
| 3pft | FMN | Flavin reductase | / | 0.462 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.462 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.462 | |
| 4wqm | FAD | Toluene-4-monooxygenase electron transfer component | 1.18.1.3 | 0.462 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.462 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.461 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.461 | |
| 1ra3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.461 | |
| 1vf2 | GTX | Glutathione S-transferase 3 | 2.5.1.18 | 0.461 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.461 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.461 | |
| 2web | PP4 | Penicillopepsin-1 | 3.4.23.20 | 0.461 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.461 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.461 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.461 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.461 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.461 | |
| 4clo | NAP | Pteridine reductase | / | 0.461 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.460 | |
| 1fml | RTL | Retinol dehydratase | / | 0.460 | |
| 1lvu | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.460 | |
| 1mmk | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.460 | |
| 1xh8 | R55 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.460 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.460 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.460 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.460 | |
| 2o12 | FMN | Chorismate synthase | / | 0.460 | |
| 2pca | SAH | Diphthine synthase | / | 0.460 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.460 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.460 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.460 | |
| 3ms4 | 21N | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.460 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.460 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.460 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.460 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.460 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.460 | |
| 4rr8 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.460 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.460 | |
| 1ci0 | FMN | Pyridoxamine 5'-phosphate oxidase | 1.4.3.5 | 0.459 | |
| 1ddu | DDU | Thymidylate synthase | / | 0.459 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.459 | |
| 1u0h | FOK | Adenylate cyclase type 2 | / | 0.459 | |
| 1u0h | FOK | Adenylate cyclase type 5 | / | 0.459 | |
| 2xje | U5P | Cytosolic purine 5'-nucleotidase | 3.1.3.5 | 0.459 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.459 | |
| 3e6y | CW1 | 14-3-3-like protein C | / | 0.459 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.459 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.459 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.459 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.459 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.459 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 4jic | FMN | GTN Reductase | / | 0.459 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.459 | |
| 5ex0 | SAH | Histone-lysine N-methyltransferase SMYD3 | 2.1.1.43 | 0.459 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 1ivs | VAA | Valine--tRNA ligase | 6.1.1.9 | 0.458 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit alpha | 1.2.4.4 | 0.458 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit beta | 1.2.4.4 | 0.458 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.458 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.458 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.458 | |
| 2ejz | SAH | Diphthine synthase | / | 0.458 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.458 | |
| 2hl0 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.458 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.458 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.458 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.458 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.458 | |
| 4e2d | FMN | Dehydrogenase | / | 0.458 | |
| 4iae | 1DX | Alr2278 protein | / | 0.458 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.458 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.458 | |
| 1fxf | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.457 | |
| 1h61 | PDN | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.457 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.457 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 2bju | IH4 | Plasmepsin-2 | 3.4.23.39 | 0.457 | |
| 2bxm | IMN | Serum albumin | / | 0.457 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.457 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.457 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.457 | |
| 2trs | PLS | Tryptophan synthase beta chain | 4.2.1.20 | 0.457 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.457 | |
| 3o7b | SAH | Ribosomal RNA small subunit methyltransferase Nep1 | / | 0.457 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.457 | |
| 3qiz | QI2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.457 | |
| 4avl | TMP | Polymerase acidic protein | / | 0.457 | |
| 4ck2 | NVU | Integrase | / | 0.457 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.457 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.457 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.457 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.457 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.457 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.456 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.456 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.456 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.456 | |
| 2e8h | SAH | Diphthine synthase | / | 0.456 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.456 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 2vdy | HCY | Corticosteroid-binding globulin | / | 0.456 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.456 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.456 | |
| 3dc3 | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.456 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.456 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.456 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.456 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.456 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.456 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.456 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.456 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.456 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.456 | |
| 4kl1 | PCG | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | / | 0.456 | |
| 4rel | KMP | Glycosyltransferase | / | 0.456 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.456 | |
| 4zu4 | 4TG | WxcM-like protein | / | 0.456 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.455 | |
| 1gpe | FAD | Glucose oxidase | 1.1.3.4 | 0.455 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.455 | |
| 1kvu | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.455 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.455 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.455 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.455 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.455 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.455 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.455 | |
| 2xiq | 5AD | Methylmalonyl-CoA mutase, mitochondrial | / | 0.455 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.455 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.455 | |
| 3e39 | FMN | Nitroreductase | / | 0.455 | |
| 3ebl | GA4 | Gibberellin receptor GID1 | / | 0.455 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.455 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.455 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.455 | |
| 4ybr | NAP | Probable nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.455 | |
| 1bdl | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.454 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1wxj | IPL | Tryptophan synthase alpha chain | / | 0.454 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.454 | |
| 2g20 | L1A | Renin | 3.4.23.15 | 0.454 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.454 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.454 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.454 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.454 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.454 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2x8i | X8I | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 2xpu | TDC | Tetracycline repressor protein class D | / | 0.454 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.454 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 3faz | NOS | Purine nucleoside phosphorylase | / | 0.454 | |
| 3nx2 | FER | Ferulic acid decarboxylase | / | 0.454 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.454 | |
| 3t7s | SAM | Uncharacterized protein | / | 0.454 | |
| 4a31 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.454 | |
| 4b2w | BZ0 | Glucose-1-phosphate thymidylyltransferase | / | 0.454 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.454 | |
| 4fm8 | 0UQ | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.454 | |
| 4ki0 | ANP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.454 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.454 | |
| 4rqu | NAD | Alcohol dehydrogenase class-P | / | 0.454 | |
| 5fbh | TCR | Extracellular calcium-sensing receptor | / | 0.454 | |
| 5ifi | PRX | Acetyl-coenzyme A synthetase | / | 0.454 | |
| 1d2s | DHT | Sex hormone-binding globulin | / | 0.453 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.453 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.453 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.453 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.453 | |
| 1sep | BIO | Sepiapterin reductase | 1.1.1.153 | 0.453 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.453 | |
| 1vf3 | GDN | Glutathione S-transferase 3 | 2.5.1.18 | 0.453 | |
| 2a4n | COA | Aac(6')-Ii protein | / | 0.453 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.453 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.453 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.453 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.453 | |
| 2vb8 | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.453 | |
| 2w2v | GTP | Ras-related C3 botulinum toxin substrate 2 | / | 0.453 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.453 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.453 | |
| 3dl9 | BCD | Vitamin D 25-hydroxylase | / | 0.453 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.453 | |
| 3ha3 | SAH | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.453 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3m2u | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.453 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.453 | |
| 3owa | FAD | Acyl-CoA dehydrogenase | / | 0.453 | |
| 3qj0 | QI3 | Botulinum neurotoxin type A | 3.4.24.69 | 0.453 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.453 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.453 | |
| 4ceq | QCH | Integrase | / | 0.453 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.453 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.453 | |
| 4rls | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.453 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.453 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.453 | |
| 1aiq | CB3 | Thymidylate synthase | / | 0.452 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.452 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.452 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 1i5c | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.452 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.452 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.452 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.452 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.452 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 2xvv | 9DN | Serum albumin | / | 0.452 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.452 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3h0b | B35 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 3h3j | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.452 | |
| 3ii4 | 3II | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.452 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.452 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.452 | |
| 3rmf | 20Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 3ssm | SAH | Mycinamicin VI 2''-O-methyltransferase | / | 0.452 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.452 | |
| 4lh7 | 1X8 | DNA ligase | / | 0.452 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.452 | |
| 4rrh | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.452 | |
| 4xba | 5GP | Aprataxin-like protein | 3 | 0.452 | |
| 5czy | SAM | Eukaryotic huntingtin interacting protein B | / | 0.452 | |
| 5hwp | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.452 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.452 | |
| 1if7 | SBR | Carbonic anhydrase 2 | 4.2.1.1 | 0.451 | |
| 1obb | NAD | Alpha-glucosidase | 3.2.1.20 | 0.451 | |
| 1y6o | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.451 | |
| 2fr1 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.451 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.451 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.451 | |
| 2ydb | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.451 | |
| 2yph | QQY | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.451 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 3dd0 | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.451 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.451 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.451 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.451 | |
| 4bzn | UGX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.451 | |
| 4fwf | FAD | Lysine-specific histone demethylase 1B | 1 | 0.451 | |
| 4j1k | 1HG | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.451 | |
| 4koa | NDP | 1,5-anhydro-D-fructose reductase | 1.1.1.292 | 0.451 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.451 | |
| 4r8q | ADP | Mitotic checkpoint serine/threonine-protein kinase BUB1 | 2.7.11.1 | 0.451 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.451 | |
| 5dhg | DGV | Nociceptin receptor | / | 0.451 | |
| 1e2n | RCA | Thymidine kinase | / | 0.450 | |
| 1f28 | UMP | Thymidylate synthase | 2.1.1.45 | 0.450 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.450 | |
| 1lp4 | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.450 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.450 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2emu | SAH | Diphthine synthase | / | 0.450 | |
| 2ge3 | ACO | Probable acetyltransferase | / | 0.450 | |
| 2nr4 | FMN | Conserved protein | / | 0.450 | |
| 2op1 | 8PC | Enoyl-ACP reductase | / | 0.450 | |
| 2rfi | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.450 | |
| 2zu8 | GDD | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.450 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.450 | |
| 3ihz | FK5 | Peptidylprolyl isomerase | / | 0.450 | |
| 3kkz | SAM | Uncharacterized protein | / | 0.450 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.450 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.450 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.450 | |
| 4boe | CLR | Japanin | / | 0.450 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.450 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.450 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.450 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.450 | |
| 4rrm | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.450 | |
| 1ae8 | AZL | Prothrombin | 3.4.21.5 | 0.449 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.449 | |
| 1c7o | PPG | Hemolysin | / | 0.449 | |
| 1dcy | I3N | Phospholipase A2, membrane associated | / | 0.449 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.449 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.449 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 1jzq | ILA | Isoleucine--tRNA ligase | 6.1.1.5 | 0.449 | |
| 1m9k | 7NI | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.449 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.449 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.449 | |
| 2p9d | SAH | Diphthine synthase | / | 0.449 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.449 | |
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 | 0.449 | |
| 2xpc | 051 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.449 | |
| 2z3l | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.449 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 3bnk | FMN | Flavoredoxin | / | 0.449 | |
| 3dv0 | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.449 | |
| 3dv0 | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.449 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.449 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.449 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.449 | |
| 3mj4 | URM | UDP-galactopyranose mutase | / | 0.449 | |
| 3slz | 3TL | Putative gag-pro-pol polyprotein | / | 0.449 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.449 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.449 | |
| 4gxs | 0YS | Glutamate receptor 2 | / | 0.449 | |
| 4ha6 | PXM | Pyridoxine 4-oxidase | / | 0.449 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.449 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.449 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.448 | |
| 1k7f | IAV | Tryptophan synthase alpha chain | / | 0.448 | |
| 1lke | DOG | Bilin-binding protein | / | 0.448 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.448 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.448 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.448 | |
| 1ppj | ANY | Cytochrome b | / | 0.448 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.448 | |
| 1toj | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.448 | |
| 1xl5 | 190 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 2c1z | U2F | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.448 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.448 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.448 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.448 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.448 | |
| 3p8z | SAH | Genome polyprotein | 2.1.1.56 | 0.448 | |
| 3q2j | CKI | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.448 | |
| 3swq | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.448 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.448 | |
| 3t70 | DU4 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | / | 0.448 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.448 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.448 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4e2x | TYD | Methyltransferase | / | 0.448 | |
| 4ef9 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.448 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.448 | |
| 5hyn | SAH | Histone-lysine N-methyltransferase EZH2 | 2.1.1.43 | 0.448 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.447 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.447 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1kf6 | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.447 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.447 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.447 | |
| 2bfo | NDP | Pteridine reductase 1 | 1.5.1.33 | 0.447 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.447 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.447 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.447 | |
| 2e17 | SAH | Diphthine synthase | / | 0.447 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2ji9 | TPW | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.447 | |
| 2pj4 | 414 | Carboxypeptidase B | / | 0.447 | |
| 2qiq | CYV | Replicase polyprotein 1ab | / | 0.447 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.447 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.447 | |
| 2vnk | FAD | NADPH:ferredoxin reductase | / | 0.447 | |
| 2wed | PP6 | Penicillopepsin-1 | 3.4.23.20 | 0.447 | |
| 2z6c | FMN | Phototropin-1 | 2.7.11.1 | 0.447 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.447 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.447 | |
| 3iex | GMP | Purine nucleoside phosphorylase | / | 0.447 | |
| 3l3m | A92 | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.447 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.447 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.447 | |
| 3mdz | EZL | Carbonic anhydrase 7 | 4.2.1.1 | 0.447 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.447 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.447 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.447 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.447 | |
| 4idp | GNP | Atlastin-1 | 3.6.5 | 0.447 | |
| 4k9o | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.447 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4loh | 1SY | Stimulator of interferon genes protein | / | 0.447 | |
| 4na4 | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.447 | |
| 4y1b | NAP | AntE | / | 0.447 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.447 | |
| 5flt | VJJ | Carbonic anhydrase 2 | 4.2.1.1 | 0.447 | |
| 1b87 | ACO | Aac(6')-Ii protein | / | 0.446 | |
| 1bl4 | AP1 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.446 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 1i5e | U5P | Uracil phosphoribosyltransferase | / | 0.446 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.446 | |
| 1pl6 | 572 | Sorbitol dehydrogenase | 1.1.1.14 | 0.446 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.446 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.446 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.446 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.446 | |
| 1wk8 | VMS | Isoleucine--tRNA ligase | 6.1.1.5 | 0.446 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.446 | |
| 2dc1 | NAD | Probable L-aspartate dehydrogenase | / | 0.446 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.446 | |
| 2ek2 | SAH | Diphthine synthase | / | 0.446 | |
| 2eka | SAH | Diphthine synthase | / | 0.446 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.446 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.446 | |
| 2glr | GTX | Glutathione S-transferase P 1 | 2.5.1.18 | 0.446 | |
| 2huv | SAH | Diphthine synthase | / | 0.446 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.446 | |
| 2pch | SAH | Diphthine synthase | / | 0.446 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.446 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.446 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.446 | |
| 3vwd | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.446 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.446 | |
| 4i8x | 6P3 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.446 | |
| 4kb9 | G79 | Protease | / | 0.446 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.446 | |
| 4r5w | XAV | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.446 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.446 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.446 | |
| 4mqt | 2CU | Muscarinic acetylcholine receptor M2 | / | 0.446 | |
| 1a8r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.445 | |
| 1lc3 | NAD | Biliverdin reductase A | 1.3.1.24 | 0.445 | |
| 1lrj | UD1 | UDP-glucose 4-epimerase | 5.1.3.2 | 0.445 | |
| 1mxf | MTX | Putative pteridine reductase 2 | / | 0.445 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.445 | |
| 1wng | SAH | Diphthine synthase | / | 0.445 | |
| 2e07 | SAH | Diphthine synthase | / | 0.445 | |
| 2eh4 | SAH | Diphthine synthase | / | 0.445 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 2fhj | H4Z | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.445 | |
| 2g27 | 4LG | Renin | 3.4.23.15 | 0.445 | |
| 2hl3 | GLU_GLU_TYR | Dynactin subunit 1 | / | 0.445 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.445 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.445 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.445 | |
| 2z0y | SAM | Ribosomal RNA small subunit methyltransferase E | / | 0.445 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 3bht | MFR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.445 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.445 | |
| 3gy9 | COA | GCN5-related N-acetyltransferase | / | 0.445 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.445 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.445 | |
| 3rdq | DTB | Streptavidin | / | 0.445 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4d8n | 0HM | Kallikrein-6 | 3.4.21 | 0.445 | |
| 4drp | 0MD | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.445 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.445 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.445 | |
| 4hmv | WUB | Phenazine biosynthesis protein PhzG | 1.4 | 0.445 | |
| 4i8z | G08 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 4ktf | 1TM | Cytochrome P450 | / | 0.445 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.445 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.445 | |
| 4xrb | NDP | Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc | / | 0.445 | |
| 4yqf | GDP | Septin-9 | / | 0.445 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1n77 | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.444 | |
| 1ur5 | NAD | Malate dehydrogenase | / | 0.444 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.444 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 2e8q | SAH | Diphthine synthase | / | 0.444 | |
| 2eld | SAH | Diphthine synthase | / | 0.444 | |
| 2fa3 | ACO | Hydroxymethylglutaryl-CoA synthase | / | 0.444 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.444 | |
| 2g97 | DGB | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.444 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.444 | |
| 2o6h | INI | 6,7-dimethyl-8-ribityllumazine synthase 1 | 2.5.1.78 | 0.444 | |
| 2ohv | NHL | Glutamate racemase | / | 0.444 | |
| 2qen | ADP | Walker-Type ATPase | / | 0.444 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.444 | |
| 2v3h | I25 | Prothrombin | 3.4.21.5 | 0.444 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.444 | |
| 2z6r | SAH | Diphthine synthase | / | 0.444 | |
| 3bgx | TMP | Thymidylate synthase | / | 0.444 | |
| 3bv2 | P38 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.444 | |
| 3elm | 24F | Collagenase 3 | 3.4.24 | 0.444 | |
| 3gon | ANP | Phosphomevalonate kinase | / | 0.444 | |
| 3hgr | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.444 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.444 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.444 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.444 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.444 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.444 | |
| 4uqs | INE | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.444 | |
| 4wdg | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 4wrk | DUP | DUTPase | / | 0.444 | |
| 1g54 | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.443 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.443 | |
| 1kw9 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.443 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.443 | |
| 1oq5 | CEL | Carbonic anhydrase 2 | 4.2.1.1 | 0.443 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.443 | |
| 1pvg | ANP | DNA topoisomerase 2 | 5.99.1.3 | 0.443 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.443 | |
| 1udc | UFM | UDP-glucose 4-epimerase | 5.1.3.2 | 0.443 | |
| 1uxk | NAD | Malate dehydrogenase | / | 0.443 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 1vg8 | GNP | Ras-related protein Rab-7a | / | 0.443 | |
| 1vik | BAY | Gag-Pol polyprotein | / | 0.443 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 1xrp | PRO_LEU_GLY_GLY | Proline iminopeptidase | 3.4.11.5 | 0.443 | |
| 1yzq | GNP | Ras-related protein Rab-6A | / | 0.443 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.443 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.443 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.443 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.443 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.443 | |
| 2gna | GDU | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.443 | |
| 2hu2 | NAD | C-terminal binding protein 1 | / | 0.443 | |
| 2ien | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.443 | |
| 2owv | SAH | Diphthine synthase | / | 0.443 | |
| 2p6i | SAH | Diphthine synthase | / | 0.443 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.443 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.443 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 2yx6 | ADP | Uncharacterized protein | / | 0.443 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.443 | |
| 3gvi | ADP | Malate dehydrogenase | / | 0.443 | |
| 3h2s | NDP | Putative NADH-flavin reductase | / | 0.443 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 3myt | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.443 | |
| 3p9t | TCL | Repressor | / | 0.443 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.443 | |
| 3tog | 079 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 3wt0 | ATP | Cell division protein FtsA | / | 0.443 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.443 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.443 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.443 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.443 | |
| 5agy | GTB | Tau class glutathione S-transferase | / | 0.443 | |
| 1ddu | CB3 | Thymidylate synthase | / | 0.442 | |
| 1h62 | ANB | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 1hdo | NAP | Flavin reductase (NADPH) | / | 0.442 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.442 | |
| 1qo8 | FAD | Fumarate reductase flavoprotein subunit | / | 0.442 | |
| 1umk | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.442 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.442 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.442 | |
| 2owk | SAH | Diphthine synthase | / | 0.442 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.442 | |
| 3bj8 | COA | Diamine acetyltransferase 1 | / | 0.442 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.442 | |
| 3eft | 3BS | Carbonic anhydrase 2 | 4.2.1.1 | 0.442 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.442 | |
| 3ih0 | ANP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.442 | |
| 3p5p | A3C | Taxadiene synthase | 4.2.3.17 | 0.442 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.442 | |
| 4b5b | BBE | Glucose-1-phosphate thymidylyltransferase | / | 0.442 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.442 | |
| 4fvr | ATP | Tyrosine-protein kinase JAK2 | / | 0.442 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.442 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.442 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.442 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.442 | |
| 5eio | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.442 | |
| 1b5d | DCM | Deoxycytidylate 5-hydroxymethyltransferase | 2.1.2.8 | 0.441 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.441 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.441 | |
| 1kh3 | ANP | Argininosuccinate synthase | / | 0.441 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.441 | |
| 1mab | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.441 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.441 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.441 | |
| 2ad5 | ADP | CTP synthase | / | 0.441 | |
| 2d81 | RB3 | Poly(3-hydroxybutyrate) depolymerase | / | 0.441 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.441 | |
| 2p2b | COA | Acetyl-coenzyme A synthetase | / | 0.441 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.441 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3coy | 53H | Pantothenate synthetase | 6.3.2.1 | 0.441 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.441 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.441 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.441 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.441 | |
| 3oag | LPQ | Renin | 3.4.23.15 | 0.441 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 3v2u | ATP | Protein GAL3 | / | 0.441 | |
| 3vuc | HHE | Renin | 3.4.23.15 | 0.441 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.441 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4bis | 8HQ | Lysine-specific demethylase 4A | 1.14.11 | 0.441 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.441 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4dae | 6CR | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.441 | |
| 4fl0 | PLP | Aminotransferase ALD1, chloroplastic | 2.6.1 | 0.441 | |
| 4gg1 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.441 | |
| 4l7f | 1V5 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.441 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.441 | |
| 4wso | NAD | Probable nicotinate-nucleotide adenylyltransferase | / | 0.441 | |
| 4y57 | F63 | Endothiapepsin | 3.4.23.22 | 0.441 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.441 | |
| 5cts | CMC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.441 | |
| 1dgm | ADN | Adenosine kinase | 2.7.1.20 | 0.440 | |
| 1eii | RTL | Retinol-binding protein 2 | / | 0.440 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.440 | |
| 1kw0 | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.440 | |
| 1m8g | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.440 | |
| 1q12 | ATP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.440 | |
| 1ra3 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1tdu | DUR | Thymidylate synthase | / | 0.440 | |
| 1w4x | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.440 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 2cts | COA | Citrate synthase, mitochondrial | 2.3.3.1 | 0.440 | |
| 2dv4 | SAH | Diphthine synthase | / | 0.440 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.440 | |
| 2jji | 0QS | Endothiapepsin | 3.4.23.22 | 0.440 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.440 | |
| 2tys | PLT | Tryptophan synthase beta chain | 4.2.1.20 | 0.440 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.440 | |
| 2zrj | AGS | Protein RecA | / | 0.440 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.440 | |
| 3ex8 | AIF | Riboflavin biosynthesis protein RibD | 1.1.1.193 | 0.440 | |
| 3fql | 79Z | Genome polyprotein | 2.7.7.48 | 0.440 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3myq | E27 | Carbonic anhydrase 2 | 4.2.1.1 | 0.440 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3uhm | RFN | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.440 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 3w1x | XRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.440 | |
| 3wcz | NAP | Aldo-keto reductase AKR2E4 | / | 0.440 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.440 | |
| 4gm4 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.440 | |
| 4gsu | DWZ | L,D-transpeptidase 2 | 2.3.2 | 0.440 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.440 | |
| 4js1 | CTN | Beta-galactoside alpha-2,6-sialyltransferase 1 | 2.4.99.1 | 0.440 | |
| 4mpr | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.440 | |
| 4n57 | ADP | APH(2'')-Id | / | 0.440 | |
| 4ock | ANP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.440 | |
| 4tx9 | AMZ | Phosphoribosyl isomerase A | / | 0.440 | |
| 4u7w | NDP | MxaA | / | 0.440 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 5k7u | SAM | N6-adenosine-methyltransferase 70 kDa subunit | / | 0.440 |