sc-PDB

List of CHEMBLId :

This value allows a number of roughly comparable measures of half-maximal response concentration/potency/affinity to be compared on a negative logarithmic scale (e.g., an IC50 measurement of 1nM would have a pChEMBL value of 9).

Uniprot Annotation

Name:	Tyrosine-protein kinase Lck
ID:	LCK_HUMAN
AC:	P06239
Organism:	Homo sapiens
Reign:	Eukaryota
TaxID:	9606
EC Number:	2.7.10.2

---

Chains:

Chain Name:	Percentage of Residues within binding site
A	85 %
C	6 %
E	9 %

---

Ligand binding site composition:

B-Factor:	64.680
Number of residues:	34
Including
Standard Amino Acids:	34
Non Standard Amino Acids:	0
Water Molecules:	0
Cofactors:
Metals:

---

Cavity properties

Ligandability	Volume (Å3)
0.677	587.250

% Hydrophobic	% Polar
41.95	58.05
According to VolSite

HET Code:	ASP_ASP_TYR_VAL_PTR
Formula:	C31H37N5O14P
Molecular weight:	734.624 g/mol
DrugBank ID:	-
Buried Surface Area:	37.98 %
Polar Surface area:	343.83 Å2

Number of
H-Bond Acceptors:	14
H-Bond Donors:	6
Rings:	2
Aromatic rings:	2
Anionic atoms:	4
Cationic atoms:	1
Rule of Five Violation:	3
Rotatable Bonds:	20

---

Mass center Coordinates

X	Y	Z
61.0861	29.4076	109.787

• 2D View
• 3D View