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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2rtfBTNStreptavidin

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2rtfBTNStreptavidin/1.000
2izhBTNStreptavidin/0.885
2rtoIMIStreptavidin/0.775
2izgBTNStreptavidin/0.760
2rtgBTNStreptavidin/0.702
2izlIMIStreptavidin/0.695
1lcwSHMStreptavidin/0.671
3wyqBTNStreptavidin/0.661
2rtqIMIStreptavidin/0.659
2rtdBTNStreptavidin/0.657
1stpBTNStreptavidin/0.656
2izfBTNStreptavidin/0.650
2rtpIMIStreptavidin/0.650
3ry2BTNStreptavidin/0.649
1sreHABStreptavidin/0.647
4bx7B4FStreptavidin/0.646
1mk5BTNStreptavidin/0.644
2y3fBTNStreptavidin/0.642
4dneDTBStreptavidin/0.636
2rteBTNStreptavidin/0.634
2fhnBNIAvidin-related protein 4/5/0.633
4gdaBTNStreptavidin/0.626
1i9hBNIStreptavidin/0.619
1srhMOBStreptavidin/0.618
2rtrIMIStreptavidin/0.618
3wznBTNStreptavidin/0.617
1srfMTBStreptavidin/0.614
1sriDMBStreptavidin/0.614
2rtiGLLStreptavidin/0.614
1swtBTNStreptavidin/0.607
1swpBTQStreptavidin/0.605
1swpBTNStreptavidin/0.604
2rtnIMIStreptavidin/0.604
1rxhBNIStreptavidin/0.602
2c4iBTNAvidin/0.599
1df8BTNStreptavidin/0.593
1srgMHBStreptavidin/0.590
1srjNABStreptavidin/0.589
1luqBTNStreptavidin/0.588
2iziBTNStreptavidin/0.587
1lczBH7Streptavidin/0.583
2aviBTNAvidin/0.583
3rdqDTBStreptavidin/0.582
2rtmIMIStreptavidin/0.581
1y52BTNAvidin-related protein 4/5/0.579
1nqmBTNStreptavidin/0.578
2izjBTNStreptavidin/0.574
2fhlBNIAvidin-related protein 4/5/0.569
1sweBTNStreptavidin/0.567
1swnBTNStreptavidin/0.558
2uywBTNAvd protein/0.557
1avdBTNAvidin/0.555
4bcsBTNAvidin-related protein 4/5/0.555
1n9mBTNStreptavidin/0.549
3ew2BTNHypothetical conserved protein/0.546
1nc9IMIStreptavidin/0.545
2uz2BTNAvd protein/0.543
1ndjBTNStreptavidin/0.540
2zscBTNTamavidin2/0.538
3t2wBTNAvidin/streptavidin/0.534
4z28BTNHoefavidin/0.534
1mepBTNStreptavidin/0.531
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.528
1n43BTNStreptavidin/0.526
4yvbBTNStreptavidin/0.521
1swrBTNStreptavidin/0.518
2rtkGLLStreptavidin/0.518
3up0D7SaceDAF-12/0.518
3d4bDZDNAD-dependent protein deacetylase/0.517
2izkGLLStreptavidin/0.515
1swdBTNStreptavidin/0.509
4bb3KKAIsopenicillin N synthase1.21.3.10.509
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.508
4psbGA3Cytokinin-specific binding protein/0.507
1yhjR6CPyridoxal kinase2.7.1.350.505
1h36R88Squalene--hopene cyclase4.2.1.1290.504
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.504
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.503
4ure1PSCyclohexanol dehydrogenase/0.503
1obnASVIsopenicillin N synthase1.21.3.10.500
2bfqAR6[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.499
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.499
1s3uTQDDihydrofolate reductase1.5.1.30.498
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.497
2jb4A14Isopenicillin N synthase1.21.3.10.497
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.497
2rbeZMGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.496
3wypBSOStreptavidin/0.496
4xd1T3QQdtf/0.496
4aosFADSteroid monooxygenase/0.495
1nw6SFGModification methylase RsrI2.1.1.720.494
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.494
1m78NDPDihydrofolate reductase1.5.1.30.493
2hvdADPNucleoside diphosphate kinase A2.7.4.60.492
2kceD16Thymidylate synthase/0.492
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.492
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.490
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.490
2jgsBTNAvidin/0.490
3biy01KHistone acetyltransferase p300/0.490
3lqfNADGalactitol dehydrogenase/0.490
4d86ADPPoly [ADP-ribose] polymerase 142.4.2.300.490
1pq944BOxysterols receptor LXR-beta/0.489
2q4wFADCytokinin dehydrogenase 71.5.99.120.489
3pqbVGPPutative oxidoreductase/0.489
4cf6CBDNAD(P)H dehydrogenase [quinone] 11.6.5.20.489
1gky5GPGuanylate kinase2.7.4.80.488
1hb1OCVIsopenicillin N synthase1.21.3.10.488
3c3xNAPEugenol synthase 11.1.1.3180.488
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.488
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.488
4twnB96Ephrin type-A receptor 32.7.10.10.488
5cb3APRO-acetyl-ADP-ribose deacetylase/0.488
1mvsDTMDihydrofolate reductase1.5.1.30.487
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.485
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.485
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.485
4zzjCNANAD-dependent protein deacetylase sirtuin-13.5.10.485
2vbpVB1Isopenicillin N synthase1.21.3.10.484
3aosJH2Hemolymph juvenile hormone binding protein/0.484
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.484
4bquCLRJapanin/0.484
4h0vNADIota toxin component Ia/0.484
3d7zGK5Mitogen-activated protein kinase 14/0.483
5fm7ADPRuvB-like helicase/0.483
1c7oPPGHemolysin/0.482
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.482
1q23FUAChloramphenicol acetyltransferase2.3.1.280.482
1wp4NDP3-hydroxyisobutyrate dehydrogenase/0.482
2r6jNDPEugenol synthase 11.1.1.3180.482
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.482
4v2gITCTetracycline repressor protein class D/0.482
1mvtDTMDihydrofolate reductase1.5.1.30.481
1uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.481
1hb3SCVIsopenicillin N synthase1.21.3.10.480
1nbiSAMGlycine N-methyltransferase2.1.1.200.480
1o1t2NHProtein farnesyltransferase subunit beta2.5.1.580.480
2fjaFADAdenylylsulfate reductase, subunit A (AprA)/0.480
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.480
4imfSI3N-acetylneuraminate lyase/0.480
1r2jFADFkbI/0.479
1s7gNADNAD-dependent protein deacylase 2/0.479
2y60M8FIsopenicillin N synthase1.21.3.10.479
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.478
4bj8BTNAvidin/0.478
1booSAHModification methylase PvuII2.1.1.1130.477
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.477
1oc1ASVIsopenicillin N synthase1.21.3.10.477
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.477
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.477
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.477
3uk6ADPRuvB-like 23.6.4.120.477
4a81DXCMajor pollen allergen Bet v 1-A/0.477
4emdC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.477
1bk0ACVIsopenicillin N synthase1.21.3.10.476
1efaNPFLactose operon repressor/0.476
1tysDHFThymidylate synthase/0.476
2a5c8DAAvidin/0.476
2ftoCB3Thymidylate synthase/0.476
2fznFADBifunctional protein PutA1.5.5.20.476
2zbaZBATrichothecene 3-O-acetyltransferase/0.476
3ehjACPSensor histidine kinase DesK2.7.13.30.476
3gwfFADCyclohexanone monooxygenase/0.476
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.476
4a2aATPCell division protein FtsA/0.476
4g6hNAIRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.476
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.475
2fjbSFDAdenylylsulfate reductase, subunit A (AprA)/0.475
2ociTYCValacyclovir hydrolase3.10.475
2r0pK2CPutative FAD-monooxygenase/0.475
3hatGLY_VAL_ARG_RNGProthrombin3.4.21.50.475
4kxjP34Nucleoprotein/0.475
4xczT3QQdtf/0.475
1ao8MTXDihydrofolate reductase1.5.1.30.474
1cjvFOKAdenylate cyclase type 2/0.474
1cjvFOKAdenylate cyclase type 5/0.474
2vbdV10Isopenicillin N synthase1.21.3.10.474
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.474
2y6fM9FIsopenicillin N synthase1.21.3.10.474
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.474
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.474
4q0kGA3Phytohormone-binding protein/0.474
8catNDPCatalase1.11.1.60.474
1h51FMNPentaerythritol tetranitrate reductase/0.473
1uzwCDHIsopenicillin N synthase1.21.3.10.473
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.473
2a0yDIHPurine nucleoside phosphorylase2.4.2.10.473
2iviACWIsopenicillin N synthase1.21.3.10.473
3af0GDPPantothenate kinase2.7.1.330.473
3cr0809Wee1-like protein kinase2.7.10.20.473
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.473
3nguADPNucleoside diphosphate kinase/0.473
3zkuHCVIsopenicillin N synthase1.21.3.10.473
4gtv7TRGeranylgeranyl transferase type-2 subunit beta2.5.1.600.473
4yddMD1DMSO reductase family type II enzyme, molybdopterin subunit/0.473
1ia3TQ5Dihydrofolate reductase1.5.1.30.472
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.472
3bm1FMNPutative NAD(P)H nitroreductase YdjA/0.472
3flwFLWMitogen-activated protein kinase 14/0.472
4dz7D02Carbonic anhydrase 24.2.1.10.472
4m9aFDAAcyl-CoA dehydrogenase/0.472
4ybnFADFlavin-nucleotide-binding protein/0.472
1ia1NDPDihydrofolate reductase1.5.1.30.471
1lf2R37Plasmepsin-23.4.23.390.471
1psa0ZLPepsin A3.4.23.10.471
2h2aDNDProbable nicotinate-nucleotide adenylyltransferase/0.471
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.471
3jpuTY4Transcriptional activator protein LasR/0.471
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.471
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.471
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.471
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.471
4pnmNU1Tankyrase-22.4.2.300.471
5iqiGNPBifunctional AAC/APH2.3.10.471
4mqt2CUMuscarinic acetylcholine receptor M2/0.471
1bim0QBRenin3.4.23.150.470
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.470
1ikgREXD-alanyl-D-alanine carboxypeptidase3.4.16.40.470
1lkeDOGBilin-binding protein/0.470
1ry8RUTAldo-keto reductase family 1 member C3/0.470
2bfpH4BPteridine reductase 11.5.1.330.470
2flhZEACytokinin-specific binding protein/0.470
2ieaTDPPyruvate dehydrogenase E1 component1.2.4.10.470
2p9gNAID-3-phosphoglycerate dehydrogenase1.1.1.950.470
3zkyWT4Isopenicillin N synthase1.21.3.10.470
4fgrADPPhosphoribosylaminoimidazole-succinocarboxamide synthase6.3.2.60.470
5eghPCEctonucleotide pyrophosphatase/phosphodiesterase family member 6/0.470
1fmjRTLRetinol dehydratase/0.469
1fvpFMANon-fluorescent flavoprotein/0.469
1kziTHGThymidylate synthase/0.469
1zdwFLVPrenyltransferase/0.469
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.469
2xlrFADPutative flavin-containing monooxygenase/0.469
2xlsFADPutative flavin-containing monooxygenase/0.469
2zjwREFCasein kinase II subunit alpha2.7.11.10.469
3d84NDPDihydrofolate reductase1.5.1.30.469
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.469
4esoNAPPutative oxidoreductase/0.469
4ggzBTNBll1558 protein/0.469
4jq4IMNAldo-keto reductase family 1 member C2/0.469
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.469
1hvyD16Thymidylate synthase2.1.1.450.468
1kwcBPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.468
1qjfACSIsopenicillin N synthase1.21.3.10.468
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.468
1xp8AGSProtein RecA/0.468
2bjsACVIsopenicillin N synthase1.21.3.10.468
2ggqTTPDual sugar-1-phosphate nucleotidylyltransferase/0.468
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.468
3bk2U5PRibonuclease J/0.468
3p62FMNPentaerythritol tetranitrate reductase/0.468
3sf6FDAGlutaryl-CoA dehydrogenase/0.468
4a83DXCMajor pollen allergen Bet v 1-A/0.468
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.468
4k4fK4FTankyrase-12.4.2.300.468
1kt6RTLRetinol-binding protein 4/0.467
2fzbTOLAldose reductase1.1.1.210.467
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.467
2he5NDPAldo-keto reductase family 1 member C211.1.10.467
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.467
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.467
3lq4TDPPyruvate dehydrogenase E1 component1.2.4.10.467
3zoiM2WIsopenicillin N synthase1.21.3.10.467
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.467
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.467
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.467
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.467
1culFOKAdenylate cyclase type 2/0.466
1culFOKAdenylate cyclase type 5/0.466
1e92HBIPteridine reductase 11.5.1.330.466
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.466
1ot7CHCBile acid receptor/0.466
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.466
1upw444Oxysterols receptor LXR-beta/0.466
2a94AP0L-lactate dehydrogenase1.1.1.270.466
2jh6894Prothrombin3.4.21.50.466
2pksG44Prothrombin3.4.21.50.466
2tohHBITyrosine 3-monooxygenase1.14.16.20.466
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.466
3pd4A3GThreonine--tRNA ligase6.1.1.30.466
3rl45GPMetallophosphoesterase MPPED23.10.466
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.466
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.466
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.466
4bcaFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.466
4dju0KKBeta-secretase 13.4.23.460.466
4lnbED5CaaX farnesyltransferase beta subunit Ram1/0.466
4ugaQ05Nitric oxide synthase oxygenase1.14.13.1650.466
4yaoFMNNADPH--cytochrome P450 reductase/0.466
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.465
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.465
1ia4TQ6Dihydrofolate reductase1.5.1.30.465
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.465
2qhxFE1Pteridine reductase 11.5.1.330.465
2w9hTOPDihydrofolate reductase1.5.1.30.465
2xrlDXTTetracycline repressor protein class D/0.465
3e2sFADBifunctional protein PutA1.5.5.20.465
3g5qFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.465
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.465
4askK0ILysine-specific demethylase 6B1.14.110.465
4n3cUD1UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.465
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.465
5irnADPNucleotide binding oligomerization domain containing 2/0.465
1cjkFOKAdenylate cyclase type 2/0.464
1cjkFOKAdenylate cyclase type 5/0.464
1jtqLY3Thymidylate synthase/0.464
1pd9CO4Dihydrofolate reductase1.5.1.30.464
2g8yNADHydroxycarboxylate dehydrogenase B/0.464
3dqrJI2Nitric oxide synthase, brain1.14.13.390.464
5d1bTSNHistone deacetylase 83.5.1.980.464
5hwpCOAHydroxymethylglutaryl-CoA synthase/0.464
1fmlRTLRetinol dehydratase/0.463
1j9zFADNADPH--cytochrome P450 reductase/0.463
1nw5SAMModification methylase RsrI2.1.1.720.463
1pqc444Oxysterols receptor LXR-beta/0.463
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.463
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.463
2vprTDCTetracycline repressor protein class H/0.463
3bw4FMNPutative 2-nitropropane dioxygenase/0.463
3e6t1A2Nitric oxide synthase, inducible1.14.13.390.463
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.463
3gqoAPRNon-structural polyprotein/0.463
3zbrNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.463
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.463
4knzCB3Thymidylate synthase/0.463
4s0vSUVOrexin receptor type 2/0.463
1dgfNDPCatalase1.11.1.60.462
1kqoDNDNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.462
1nzq162Prothrombin3.4.21.50.462
1tllFADNitric oxide synthase, brain1.14.13.390.462
1xf0ASDAldo-keto reductase family 1 member C3/0.462
2a0xDIHPurine nucleoside phosphorylase2.4.2.10.462
2znq401Peroxisome proliferator-activated receptor delta/0.462
3b9oFMNAlkane monoxygenase/0.462
3c14FOKAdenylate cyclase type 2/0.462
3c14FOKAdenylate cyclase type 5/0.462
3ggcH26Hypoxanthine-guanine phosphoribosyltransferase2.4.2.80.462
3oqfS51Renin3.4.23.150.462
3up3XCAaceDAF-12/0.462
3vfqAR6Poly [ADP-ribose] polymerase 142.4.2.300.462
4fqsLYAThymidylate synthase ThyA/0.462
4hy6FJ1Heat shock protein HSP 90-alpha/0.462
4kfqKFQGlutamate receptor ionotropic, NMDA 1/0.462
4o8aFADBifunctional protein PutA1.2.1.880.462
1jnrFADAdenylylsulfate reductase, subunit A (AprA)/0.461
1jnzFADAdenylylsulfate reductase, subunit A (AprA)/0.461
1qbqHFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.461
1qbqHFPProtein farnesyltransferase subunit beta2.5.1.580.461
1tehNADAlcohol dehydrogenase class-31.1.1.10.461
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
2f3815MAldo-keto reductase family 1 member C3/0.461
2pbzATPUncharacterized protein/0.461
2wetFADTryptophan 5-halogenase/0.461
3uoyFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.461
3v2uATPProtein GAL3/0.461
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.461
4dieC5PCytidylate kinase/0.461
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.461
4kbyC2EStimulator of interferon genes protein/0.461
1axwMTXThymidylate synthase/0.460
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.460
2bfaCB3Pteridine reductase 11.5.1.330.460
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.460
3bi6396Wee1-like protein kinase2.7.10.20.460
3ielU5PRibonuclease TTHA02523.10.460
3jq8DX3Pteridine reductase, putative/0.460
3klbFMNUncharacterized protein/0.460
3nx2FERFerulic acid decarboxylase/0.460
3q7fED2Uncharacterized protein/0.460
4dbs0HVAldo-keto reductase family 1 member C3/0.460
4j6dTESCytochrome P450 monooxygenase/0.460
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.460
4rtmSAMDNA adenine methylase2.1.1.720.460
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.460
1dhfFOLDihydrofolate reductase1.5.1.30.459
1ef92CPMethylmalonyl-CoA decarboxylase4.1.1.410.459
1n5dNDPCarbonyl reductase [NADPH] 1/0.459
1p8dCO1Oxysterols receptor LXR-beta/0.459
1v93FADMethylenetetrahydrofolate reductase/0.459
2a2sGSNGlutathione S-transferase P2.5.1.180.459
2dvlFADAcyl-CoA dehydrogenase/0.459
2g97DGBNicotinamide phosphoribosyltransferase2.4.2.120.459
2hq9FADMll6688 protein/0.459
2il2LIXRenin3.4.23.150.459
2w3mFOLDihydrofolate reductase1.5.1.30.459
2xtbKRMAdenosine kinase, putative/0.459
2xveFADPutative flavin-containing monooxygenase/0.459
2ym1FADPhenylacetone monooxygenase1.14.13.920.459
2zpaADPtRNA(Met) cytidine acetyltransferase TmcA/0.459
3arvSAUChitinase A/0.459
3q71AR6Poly [ADP-ribose] polymerase 142.4.2.300.459
3qm4PN0Cytochrome P450 2D6/0.459
4j6cSTRCytochrome P450 monooxygenase/0.459
4uy6SAHHistidine N-alpha-methyltransferase/0.459
1n4pCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.458
1nceCB3Thymidylate synthase/0.458
1pr4MTPPurine nucleoside phosphorylase DeoD-type/0.458
1qiqACCIsopenicillin N synthase1.21.3.10.458
2i0zFADNAD(FAD)-utilizing dehydrogenases/0.458
2ivfMGDAlpha-subunit of ethylbenzene dehydrogenase/0.458
2ovvPFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.458
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.458
3qlrNDPDihydrofolate reductase1.5.1.30.458
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
4df2FMNNADPH dehydrogenase/0.458
4dz5NAPAldo-keto reductase family 1 member C3/0.458
4egbNADdTDP-glucose 4,6-dehydratase/0.458
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.458
4gevCB3Thymidylate synthase/0.458
4hlg20BTankyrase-22.4.2.300.458
4jlj1NMDeoxycytidine kinase2.7.1.740.458
4n3l2FNProthrombin3.4.21.50.458
4ocpADPN-acetylhexosamine 1-kinase2.7.1.1620.458
4uofDATNucleoside diphosphate kinase/0.458
4uohADPNucleoside diphosphate kinase/0.458
5ch7MD1DMSO reductase family type II enzyme, molybdopterin subunit/0.458
5iubCLRAdenosine receptor A2a/0.458
5jtbZMAAdenosine receptor A2a/0.458
1dhiMTXDihydrofolate reductase1.5.1.30.457
1e2nRCAThymidine kinase/0.457
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
1efvFADElectron transfer flavoprotein subunit alpha, mitochondrial/0.457
1ex75GPGuanylate kinase2.7.4.80.457
1mrqSTRAldo-keto reductase family 1 member C1/0.457
1powFADPyruvate oxidase1.2.3.30.457
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
1z71L17Prothrombin3.4.21.50.457
1zrb062Prothrombin3.4.21.50.457
2jj2ANPATP synthase subunit beta, mitochondrial3.6.3.140.457
2v2qNVG4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.457
2vqbFADPutative flavin-containing monooxygenase/0.457
2xlpFADPutative flavin-containing monooxygenase/0.457
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.457
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.457
3h4vDVPPteridine reductase 11.5.1.330.457
3hxdBD7Geranylgeranyl transferase type-2 subunit beta2.5.1.600.457
3inxJZCHeat shock protein HSP 90-alpha/0.457
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.457
3uaxNOSPurine nucleoside phosphorylase DeoD-type/0.457
3vf60H6Glucokinase2.7.1.20.457
3w8wFADPutative FAD-dependent oxygenase EncM/0.457
4da8BG2Purine nucleoside phosphorylase DeoD-type2.4.2.10.457
4dymIYZActivin receptor type-12.7.11.300.457
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
4phlPILPhosphodiesterase/0.457
5hs1VORLanosterol 14-alpha demethylase/0.457
1cdeGARPhosphoribosylglycinamide formyltransferase/0.456
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.456
1h66RH1NAD(P)H dehydrogenase [quinone] 11.6.5.20.456
1n83CLRNuclear receptor ROR-alpha/0.456
1naiNADUDP-glucose 4-epimerase5.1.3.20.456
1o5rFR9Adenosine deaminase3.5.4.40.456
1y0s331Peroxisome proliferator-activated receptor delta/0.456
1ygkRRCPyridoxal kinase2.7.1.350.456
2nnlERDDihydroflavonol 4-reductase1.1.1.2190.456
2xvhFADPutative flavin-containing monooxygenase/0.456
2xw7NDPDihydrofolate reductase/0.456
3ad9NADSubunit alpha of sarocosine oxidase/0.456
3cluFADElectron transfer flavoprotein subunit alpha/0.456
3ibdCPZCytochrome P450 2B61.14.130.456
3iocA5DPantothenate synthetase6.3.2.10.456
3n0hTOPDihydrofolate reductase1.5.1.30.456
3pm9FADPutative oxidoreductase/0.456
3vgwNVZAvidin/0.456
4e5h0N8Polymerase acidic protein/0.456
4eqwCOACoenzyme A disulfide reductase/0.456
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
4hmsFMNPhenazine biosynthesis protein PhzG1.40.456
4i4b1CV3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.456
4idgNADPutative UDP-glucose 4-epimerase/0.456
4rrxLURProstaglandin G/H synthase 21.14.99.10.456
4xg1LLPDiaminopimelate decarboxylase/0.456
5iqeGNPBifunctional AAC/APH2.3.10.456
1bsvNDPGDP-L-fucose synthase/0.455
1h69ARHNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
1l8aTDPPyruvate dehydrogenase E1 component1.2.4.10.455
1nhkCMPNucleoside diphosphate kinase2.7.4.60.455
1qorNDPQuinone oxidoreductase 1/0.455
1ta6177Prothrombin3.4.21.50.455
2g226IGRenin3.4.23.150.455
2j9lATPH(+)/Cl(-) exchange transporter 5/0.455
2rtlIMIStreptavidin/0.455
3bg7FADPyranose 2-oxidase/0.455
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
3el7PD3Proto-oncogene tyrosine-protein kinase Src2.7.10.20.455
3fr5I4AFatty acid-binding protein, adipocyte/0.455
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.455
3maaFKPAdenylate cyclase type 2/0.455
3maaFKPAdenylate cyclase type 5/0.455
3nxyD2HDihydrofolate reductase1.5.1.30.455
3owaFADAcyl-CoA dehydrogenase/0.455
4bfvZVVPantothenate kinase2.7.1.330.455
4fxy0W2Neurolysin, mitochondrial3.4.24.160.455
4mrm2BYGamma-aminobutyric acid type B receptor subunit 1/0.455
5eccNAPDehydrofolate reductase type I/0.455
5ig2NADShort-chain dehydrogenase/reductase SDR/0.455
1dljUGAUDP-glucose 6-dehydrogenase/0.454
1dr3TAPDihydrofolate reductase1.5.1.30.454
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.454
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.454
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
2hveADPNucleoside diphosphate kinase A2.7.4.60.454
2vcmM11Isopenicillin N synthase1.21.3.10.454
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.454
2xnvVU3Soluble acetylcholine receptor/0.454
3e7tB14Nitric oxide synthase, inducible1.14.13.390.454
3frkTQPQdtB/0.454
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
3up4NAP2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.454
3w5rLOAVitamin D3 receptor/0.454
4bhw01KHistone acetyltransferase p300/0.454
4eb5PLPCysteine desulfurase IscS 2/0.454
4eiyZMAAdenosine receptor A2a/0.454
4gyy12VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.454
4j6bPLOCytochrome P450 monooxygenase/0.454
4k36SAMAnaerobic sulfatase-maturating enzyme1.8.980.454
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.454
4ldeP0GBeta-2 adrenergic receptor/0.454
1blzACVIsopenicillin N synthase1.21.3.10.453
1d6w00RProthrombin3.4.21.50.453
1eg2MTAModification methylase RsrI2.1.1.720.453
1p33MTXPteridine reductase 11.5.1.330.453
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.453
1tduCB3Thymidylate synthase/0.453
1vzqSHYProthrombin3.4.21.50.453
1x8lOXRRetinol dehydratase/0.453
1yqzCOACoenzyme A disulfide reductase/0.453
2bfmTOPPteridine reductase 11.5.1.330.453
2f0y3MNProtein farnesyltransferase subunit beta2.5.1.580.453
2iko7IGRenin3.4.23.150.453
2ix5FADAcyl-coenzyme A oxidase 4, peroxisomal1.3.3.60.453
2iyaZIOOleandomycin glycosyltransferase/0.453
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.453
2oc9IMHPurine nucleoside phosphorylase2.4.2.10.453
2po7CHDFerrochelatase, mitochondrial4.99.1.10.453
2x93X93Angiotensin-converting enzyme3.4.15.10.453
2z1qFADAcyl-CoA dehydrogenase/0.453
3p3c3P3UDP-3-O-acyl-N-acetylglucosamine deacetylase/0.453
3t4nADP5'-AMP-activated protein kinase subunit gamma/0.453
4b64NAPL-ornithine N(5)-monooxygenase/0.453
4c49HCYCorticosteroid-binding globulin/0.453
4dvi2IWTankyrase-12.4.2.300.453
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.453
4f32N323-oxoacyl-[acyl-carrier-protein] synthase 2/0.453
4oaqNDPR-specific carbonyl reductase/0.453
4rujVDXVitamin D3 receptor A/0.453
4djhJDCKappa-type opioid receptor/0.453
1afeALZProthrombin3.4.21.50.452
1c4yIH3Prothrombin3.4.21.50.452
1i75NOJCyclomaltodextrin glucanotransferase2.4.1.190.452
1mdtAPUDiphtheria toxin/0.452
1oytFSNProthrombin3.4.21.50.452
1s3vTQDDihydrofolate reductase1.5.1.30.452
1tqf32PBeta-secretase 13.4.23.460.452
1trgCB3Thymidylate synthase/0.452
1ty9FMNPhenazine biosynthesis protein PhzG1.40.452
1w7h3IPMitogen-activated protein kinase 14/0.452
2fs4PZ1Renin3.4.23.150.452
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.452
2in6839Wee1-like protein kinase2.7.10.20.452
2j14GNIPeroxisome proliferator-activated receptor delta/0.452
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.452
2qtaTDPPyruvate dehydrogenase E1 component1.2.4.10.452
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.452
2v13C40Renin3.4.23.150.452
2x6o2TCTetracycline repressor protein class D/0.452
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3f0aACOSpermidine N(1)-acetyltransferase/0.452
3gkjHC3Niemann-Pick C1 protein/0.452
4dk70KSOxysterols receptor LXR-beta/0.452
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
4ho9UTPGlucose-1-phosphate thymidylyltransferase/0.452
4pzrCOAHistone acetyltransferase p300/0.452
4xqcNADHomospermidine synthase2.5.1.440.452
1afsTES3-alpha-hydroxysteroid dehydrogenase1.1.1.500.451
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.451
1dhjMTXDihydrofolate reductase1.5.1.30.451
1dr5NAPDihydrofolate reductase1.5.1.30.451
1o6rR19Squalene--hopene cyclase4.2.1.1290.451
1re0AFBADP-ribosylation factor 1/0.451
1re0AFBARF guanine-nucleotide exchange factor 1/0.451
1ry0PG2Aldo-keto reductase family 1 member C3/0.451
1thnADPAnti-sigma F factor/0.451
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
1ypkCCRProthrombin3.4.21.50.451
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
2q7vFADThioredoxin reductase/0.451
2w6qOA5Biotin carboxylase6.3.4.140.451
2wsiFADFAD synthase2.7.7.20.451
2xfyACXBeta-amylase3.2.1.20.451
3atyFMNProstaglandin F2a synthase/0.451
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.451
3jwuJ11Nitric oxide synthase, brain1.14.13.390.451
3lpkZ76Beta-secretase 13.4.23.460.451
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
4g8bHL6Alpha/beta hydrolase fold protein/0.451
4gdcNDPUDP-galactopyranose mutase/0.451
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.451
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.451
4iarERM5-hydroxytryptamine receptor 1B/0.451
4lxk1YTBeta-secretase 13.4.23.460.451
4to0DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.451
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.451
4uymVOR14-alpha sterol demethylase Cyp51B/0.451
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.451
4xrgNADHomospermidine synthase2.5.1.440.451
5d9j0N8Polymerase acidic protein/0.451
5k2cZMAAdenosine receptor A2a/0.451
1b2lNDCAlcohol dehydrogenase1.1.1.10.450
1fp1HCCIsoliquiritigenin 2'-O-methyltransferase/0.450
1kw9BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.450
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.450
2aqbTL63-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.450
2g1r3IGRenin3.4.23.150.450
2g247IGRenin3.4.23.150.450
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.450
2qqfA1RNAD-dependent protein deacetylase HST23.5.10.450
2uuk897Prothrombin3.4.21.50.450
2ywlFADThioredoxin reductase related protein/0.450
2zryFNRIsopentenyl-diphosphate delta-isomerase/0.450
3a25SAMtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase/0.450
3djlFADPutative acyl-CoA dehydrogenase AidB1.3.990.450
3h3qH13Collagen type IV alpha-3-binding protein/0.450
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.450
3nf4FADAcyl-CoA dehydrogenase domain-containing protein/0.450
3sfy3FYUncharacterized protein/0.450
4b63NAPL-ornithine N(5)-monooxygenase/0.450
4b67NAPL-ornithine N(5)-monooxygenase/0.450
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4irnFADAnaB/0.450
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
4ug2NGIAdenosine receptor A2a/0.450
1ay0TPPTransketolase 12.2.1.10.449
1dfoFFOSerine hydroxymethyltransferase2.1.2.10.449
1f28F89Thymidylate synthase2.1.1.450.449
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1kw8BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.449
1o6qR17Squalene--hopene cyclase4.2.1.1290.449
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.449
1xs7MMIBeta-secretase 13.4.23.460.449
1zemNADXylitol dehydrogenase/0.449
2ou2ACOHistone acetyltransferase KAT5/0.449
2uupLK4UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.449
3b9lAZZSerum albumin/0.449
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.449
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.600.449
3lkhLT6Genome polyprotein2.7.7.480.449
3oimVZ5Carbonic anhydrase 24.2.1.10.449
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4hkfACOAlpha-tubulin N-acetyltransferase 1/0.449
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.449
4yp5NAPNicotinamide-nucleotide adenylyltransferase2.7.7.10.449
4z24FADPutative GMC-type oxidoreductase R13510.449
5c3jFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.449
5iqdGNPBifunctional AAC/APH2.3.10.449
5k2dZMAAdenosine receptor A2a/0.449
4zj8SUVOrexin receptor type 1/0.449
3sn6P0GBeta-2 adrenergic receptor/0.449
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.448
1eyyNAPNADP-dependent fatty aldehyde dehydrogenase1.2.1.40.448
1h35R01Squalene--hopene cyclase4.2.1.1290.448
1k3yGTXGlutathione S-transferase A12.5.1.180.448
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.448
1qrpHH0Pepsin A-43.4.23.10.448
1snyNAPLD36273p/0.448
1uyePU9Heat shock protein HSP 90-alpha/0.448
1yreCOAUncharacterized protein/0.448
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.448
2bdyUNBProthrombin3.4.21.50.448
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.448
2fzhDH1Dihydrofolate reductase1.5.1.30.448
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
2ofv242Tyrosine-protein kinase Lck2.7.10.20.448
2r8oT5XTransketolase 1/0.448
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.448
3eblGA4Gibberellin receptor GID1/0.448
3f03FMNPentaerythritol tetranitrate reductase/0.448
3fktSIIBeta-secretase 13.4.23.460.448
3fp0FP015-O-acetyltransferase/0.448
3fznD7KBenzoylformate decarboxylase4.1.1.70.448
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
3hcrCHDFerrochelatase, mitochondrial4.99.1.10.448
3imeBZ2Pantothenate synthetase6.3.2.10.448
3l5bBDOBeta-secretase 13.4.23.460.448
3mb601ICasein kinase II subunit alpha2.7.11.10.448
3n5yXFLNitric oxide synthase, brain1.14.13.390.448
3njoPYVAbscisic acid receptor PYR1/0.448
3q43D66M1 family aminopeptidase3.4.110.448
3q5pTACMultidrug-efflux transporter 1 regulator/0.448
3uovFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.448
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.448
4a84DXCMajor pollen allergen Bet v 1-A/0.448
4avlTMPPolymerase acidic protein/0.448
4eqsCOACoenzyme A disulfide reductase/0.448
4kebFOLDihydrofolate reductase1.5.1.30.448
4na4A1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.448
7catNDPCatalase1.11.1.60.448
5g53NECAdenosine receptor A2a/0.448
1a9sNOSPurine nucleoside phosphorylase2.4.2.10.447
1d9i00PProthrombin3.4.21.50.447
1dr3HBIDihydrofolate reductase1.5.1.30.447
1eq2ADQADP-L-glycero-D-manno-heptose-6-epimerase/0.447
1fm4DXCMajor pollen allergen Bet v 1-L/0.447
1gpuTHDTransketolase 12.2.1.10.447
1k27MTMS-methyl-5'-thioadenosine phosphorylase/0.447
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.447
1qtiGNTAcetylcholinesterase3.1.1.70.447
1rt9IMHPurine nucleoside phosphorylase2.4.2.10.447
1tsxUMPThymidylate synthase/0.447
1yplRA8Prothrombin3.4.21.50.447
1zdfUPGGlycogenin-12.4.1.1860.447
2igyA2TPlasmepsin 2/0.447
2ikuLIYRenin3.4.23.150.447
2lfoGCHFatty acid-binding protein, liver/0.447
2o8jSAHHistone-lysine N-methyltransferase EHMT2/0.447
2ohvNHLGlutamate racemase/0.447
2vn0TDZCytochrome P450 2C8/0.447
2z3uCRRCytochrome P450/0.447
2zs8ADPPantothenate kinase2.7.1.330.447
2zs9ADPPantothenate kinase2.7.1.330.447
3bgxTMPThymidylate synthase/0.447
3bhrTHGThymidylate synthase/0.447
3biu10UProthrombin3.4.21.50.447
3dd0EZLCarbonic anhydrase 24.2.1.10.447
3ddw055Glycogen phosphorylase, liver form2.4.1.10.447
3drcMTXDihydrofolate reductase1.5.1.30.447
3eq02TSProthrombin3.4.21.50.447
3kozZ97D-ornithine 4,5-aminomutase subunit beta/0.447
3nr4PYVAbscisic acid receptor PYL2/0.447
3otqMZLBifunctional epoxide hydrolase 23.3.2.100.447
3saxE50Carbonic anhydrase 24.2.1.10.447
3tm5SFGUncharacterized protein/0.447
3zqtTESAndrogen receptor/0.447
4ap1FADSteroid monooxygenase/0.447
4b4w9L9Bifunctional protein FolD/0.447
4gh5NADShort-chain dehydrogenase/reductase SDR/0.447
4imoPWZProstaglandin-H2 D-isomerase5.3.99.20.447
4lva20MNicotinamide phosphoribosyltransferase2.4.2.120.447
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.447
4mr92BXGamma-aminobutyric acid type B receptor subunit 1/0.447
4uocNCNCinA-like protein/0.447
5iu4ZMAAdenosine receptor A2a/0.447
1a27ESTEstradiol 17-beta-dehydrogenase 11.1.1.620.446
1sb1165Prothrombin3.4.21.50.446
1tj1FADBifunctional protein PutA1.5.5.20.446
2ea2F77Methionine aminopeptidase 2/0.446
2g1o2IGRenin3.4.23.150.446
2p9eNAID-3-phosphoglycerate dehydrogenase1.1.1.950.446
2q9fC3SCholesterol 24-hydroxylase/0.446
2v59LZKBiotin carboxylase6.3.4.140.446
2vkvTDCTetracycline repressor protein class D/0.446
2xysSY9Soluble acetylcholine receptor/0.446
2yhuWHFPteridine reductase/0.446
2yjxYJXHeat shock protein HSP 90-alpha/0.446
3exnACOProbable acetyltransferase/0.446
3gg2UGASugar dehydrogenase, UDP-glucose/GDP-mannose dehydrogenase family/0.446
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.446
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.446
3nytULPUDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.446
3oy0OY0Carbonic anhydrase 24.2.1.10.446
3uyk0CXProbable NDP-rhamnosyltransferase/0.446
4c6zTLE3-oxoacyl-ACP synthase/0.446
4gn6TYLLactoperoxidase1.11.1.70.446
4kwhNAPReductase homolog/0.446
4ockANPN-acetylhexosamine 1-kinase2.7.1.1620.446
4rtoSFGDNA adenine methylase2.1.1.720.446
4ubvCOASteroid 3-ketoacyl-CoA thiolase/0.446
4z87GDPInosine-5'-monophosphate dehydrogenase/0.446
5bt42LOBromodomain-containing protein 4/0.446
5fd8A5APutative carboxypeptidase yocD/0.446
3emlZMAAdenosine receptor A2a/0.446
1d3pBT3Prothrombin3.4.21.50.445
1njaDCMThymidylate synthase/0.445
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.445
1qk35GPHypoxanthine-guanine-xanthine phosphoribosyltransferase2.4.2.220.445
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.445
1x1dSAHC-20 methyltransferase/0.445
1yc2NADNAD-dependent protein deacylase 2/0.445
1ypeUIPProthrombin3.4.21.50.445
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.445
2bu9HFVIsopenicillin N synthase1.21.3.10.445
2c12FADNitroalkane oxidase1.7.3.10.445
2c29NAPDihydroflavonol 4-reductase/0.445
2r6kGTXGlutathione S-transferase A12.5.1.180.445
2v2vV124-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.445
2vkeTACTetracycline repressor protein class D/0.445
2w4qCBWProstaglandin reductase 21.3.1.480.445
2y05NAPProstaglandin reductase 1/0.445
2ydbNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.445
2ylrFADPhenylacetone monooxygenase1.14.13.920.445
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.445
3copADPGlycogen synthase2.4.1.210.445
3dcwEZLCarbonic anhydrase 24.2.1.10.445
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.445
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.445
3f0rTSNHistone deacetylase 83.5.1.980.445
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
3gluLYS_VAL_METNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.445
3ivgFG5Pantothenate synthetase6.3.2.10.445
3lakKR1Gag-Pol polyprotein2.7.7.490.445
3nmpPYVAbscisic acid receptor PYL2/0.445
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.445
3pg3DG7Mitogen-activated protein kinase 14/0.445
3q8uADPNucleoside diphosphate kinase/0.445
3rupADPBiotin carboxylase6.3.4.140.445
3tk3CPZCytochrome P450 2B41.14.14.10.445
3to3ATPPetrobactin biosynthesis protein AsbB/0.445
3v0o4GWHisto-blood group ABO system transferase/0.445
3v76FDAUncharacterized protein/0.445
4a862ANMajor pollen allergen Bet v 1-A/0.445
4aoxFADSteroid monooxygenase/0.445
4b1rITCTetracycline repressor protein class D/0.445
4gbeSAHDNA adenine methylase2.1.1.720.445
4rrfA3SThreonine--tRNA ligase6.1.1.30.445
4ubuCOASteroid 3-ketoacyl-CoA thiolase/0.445
4y9lFADAcyl-CoA dehydrogenase family member 11/0.445
5k2bZMAAdenosine receptor A2a/0.445
1ci7UMPThymidylate synthase2.1.1.450.444
1dnaCB3Thymidylate synthase/0.444
1g2vTTPGlucose-1-phosphate thymidylyltransferase/0.444
1jpaANPEphrin type-B receptor 22.7.10.10.444
1me6IVSPlasmepsin-23.4.23.390.444
1tduDURThymidylate synthase/0.444
1w6hTITPlasmepsin-23.4.23.390.444
1yl7NAI4-hydroxy-tetrahydrodipicolinate reductase/0.444
1zsbAZMCarbonic anhydrase 24.2.1.10.444
2g1n1IGRenin3.4.23.150.444
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.444
2gvdFKPAdenylate cyclase type 2/0.444
2gvdFKPAdenylate cyclase type 5/0.444
2v3oI26Prothrombin3.4.21.50.444
2w6pOA4Biotin carboxylase6.3.4.140.444
2zhe13UProthrombin3.4.21.50.444
3dux64UProthrombin3.4.21.50.444
3elm24FCollagenase 33.4.240.444
3lpiZ74Beta-secretase 13.4.23.460.444
3nga3NGCasein kinase II subunit alpha2.7.11.10.444
3nnz59WNitric oxide synthase, brain1.14.13.390.444
3pce3HPProtocatechuate 3,4-dioxygenase alpha chain1.13.11.30.444
3pce3HPProtocatechuate 3,4-dioxygenase beta chain1.13.11.30.444
3qfrFMNNADPH--cytochrome P450 reductase/0.444
3t88S0N1,4-dihydroxy-2-naphthoyl-CoA synthase/0.444
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.444
4b65NDPL-ornithine N(5)-monooxygenase/0.444
4bfuZVUPantothenate kinase2.7.1.330.444
4d03NAPPhenylacetone monooxygenase1.14.13.920.444
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.444
4kne1CYDihydrofolate reductase1.5.1.30.444
4mv1ADPBiotin carboxylase6.3.4.140.444
4rrgA3TThreonine--tRNA ligase6.1.1.30.444
4xba5GPAprataxin-like protein30.444
5iqbGNPBifunctional AAC/APH2.3.10.444
1a9zUPGUDP-glucose 4-epimerase5.1.3.20.443
1dmyAZMCarbonic anhydrase 5A, mitochondrial4.2.1.10.443
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1kmyBPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.443
1lelBH7Avidin/0.443
1lf3EH5Plasmepsin-23.4.23.390.443
1ly4COQDihydrofolate reductase1.5.1.30.443
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.443
1rd4L08Integrin alpha-L/0.443
1toxNADDiphtheria toxin/0.443
1v35NAIEnoyl-ACP reductase/0.443
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.443
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2dhfDZFDihydrofolate reductase1.5.1.30.443
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.443
2gjnFMNNitronate monooxygenase1.13.12.160.443
2gv8NDPThiol-specific monooxygenase1.14.130.443
2hl1A3SThreonine--tRNA ligase6.1.1.30.443
2ozuACOHistone acetyltransferase KAT6A/0.443
2pl0STITyrosine-protein kinase Lck2.7.10.20.443
2rfiSAHHistone-lysine N-methyltransferase EHMT1/0.443
2vmyFFOSerine hydroxymethyltransferase/0.443
2xpvMIYTetracycline repressor protein class D/0.443
2xtnGTPGTPase IMAP family member 2/0.443
2ylwFADPhenylacetone monooxygenase1.14.13.920.443
2zg050UProthrombin3.4.21.50.443
3eksCY9Actin-5C/0.443
3fhxPLPPyridoxal kinase2.7.1.350.443
3gdpFAD(R)-mandelonitrile lyase 24.1.2.100.443
3i1y33NBifunctional epoxide hydrolase 23.3.2.100.443
3kjgADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.443
3o8gO8GHTH-type transcriptional regulator EthR/0.443
3oikWZBCarbonic anhydrase 24.2.1.10.443
3p3zP3ZPutative cytochrome P450/0.443
3qwbNDPProbable quinone oxidoreductase1.6.5.50.443
3vydVYDRenin3.4.23.150.443
3w4yFADMitochondrial FAD-linked sulfhydryl oxidase ERV11.8.3.20.443
3w78CBDFMN-dependent NADH-azoreductase/0.443
4az29MUProthrombin3.4.21.50.443
4bfwZVWPantothenate kinase2.7.1.330.443
4bkjSTIEpithelial discoidin domain-containing receptor 12.7.10.10.443
4c73TLH3-oxoacyl-ACP synthase/0.443
4fhbFOLDihydrofolate reductase1.5.1.30.443
4hmn16JAldo-keto reductase family 1 member C3/0.443
4nbwNADShort-chain dehydrogenase/reductase SDR/0.443
4pztSOPHistone acetyltransferase p300/0.443
4rr7A3SProbable threonine--tRNA ligase 26.1.1.30.443
4wriOKAOkadaic acid binding protein 2-alpha/0.443
5cmx0G6Prothrombin3.4.21.50.443
5e5h0T1Succinyl-CoA:acetate CoA-transferase/0.443
5f8fSFGPossible transcriptional regulatory protein/0.443
5iu86DZAdenosine receptor A2a/0.443
4uhrNGIAdenosine receptor A2a/0.443
3qakUKAAdenosine receptor A2a/0.443
1be4PCGNucleoside diphosphate kinase A 22.7.4.60.442
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.442
1d4pBPPProthrombin3.4.21.50.442
1ddtAPUDiphtheria toxin/0.442
1fxoTMPGlucose-1-phosphate thymidylyltransferase/0.442
1ix1BB2Peptide deformylase/0.442
1mb9ATPCarboxyethyl-arginine beta-lactam-synthase6.3.3.40.442
1mp0NADAlcohol dehydrogenase class-31.1.1.10.442
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.442
1reqDCAMethylmalonyl-CoA mutase large subunit5.4.99.20.442
1rsgFADPolyamine oxidase FMS1/0.442
1u1cBAUUridine phosphorylase2.4.2.30.442
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.442
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.442
1z7yAA5Cysteine synthase 12.5.1.470.442
2b1i93ABifunctional purine biosynthesis protein PURH2.1.2.30.442
2bf7HBIPteridine reductase 11.5.1.330.442
2bunFADAppA protein/0.442
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.442
2d81RB3Poly(3-hydroxybutyrate) depolymerase/0.442
2gcgNDPGlyoxylate reductase/hydroxypyruvate reductase1.1.1.790.442
2hb8MVDVitamin D3 receptor/0.442
2hl2SSAThreonine--tRNA ligase6.1.1.30.442
2iejS48Protein farnesyltransferase subunit beta2.5.1.580.442
2o6hINI6,7-dimethyl-8-ribityllumazine synthase 12.5.1.780.442
2pitDHTAndrogen receptor/0.442
2wzySQXSoluble acetylcholine receptor/0.442
3fu9KIBLaccase-11.10.3.20.442
3m98E02Carbonic anhydrase 24.2.1.10.442
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.442
3q44D50M1 family aminopeptidase3.4.110.442
3sufSUEPolyprotein/0.442
3zhsTD6Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.442
4awp99AHeat shock protein HSP 90-alpha/0.442
4ax9N5NProthrombin3.4.21.50.442
4b1iA8PPoly(ADP-ribose) glycohydrolase3.2.1.1430.442
4eh8IRGMitogen-activated protein kinase 14/0.442
4gdpFADPolyamine oxidase FMS1/0.442
4h6pFMNChromate reductase/0.442
4haiI23Bifunctional epoxide hydrolase 23.1.3.760.442
4ivrN50Thymidine kinase/0.442
4l4xNDPAmphI/0.442
4la7A1OAbscisic acid receptor PYL2/0.442
4mo2FADUDP-galactopyranose mutase/0.442
4mzuTYDWxcM-like protein/0.442
4tm0NAPKtzI/0.442
4wdfA2P2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.442
4yerADPAntibiotic ABC transporter, ATP-binding protein, putative/0.442
4zu44TGWxcM-like protein/0.442
5fsyAR6Uncharacterized protein/0.442
6ctsCICCitrate synthase, mitochondrial2.3.3.10.442
5k2aZMAAdenosine receptor A2a/0.442
4xnw2IDP2Y purinoceptor 1/0.442
1aiqCB3Thymidylate synthase/0.441
1dduCB3Thymidylate synthase/0.441
1fy7COAHistone acetyltransferase ESA1/0.441
1gc5ADPADP-dependent glucokinase2.7.1.1470.441
1gj5130Prothrombin3.4.21.50.441
1j49NADD-lactate dehydrogenase1.1.1.280.441
1n06ADPRiboflavin kinase2.7.1.260.441
1ut6A8NAcetylcholinesterase3.1.1.70.441
1ve3SAMUncharacterized protein/0.441
2cvzNDP3-hydroxyisobutyrate dehydrogenase/0.441
2dxfGNPNucleoside diphosphate kinase2.7.4.60.441
2fj1CTCTetracycline repressor protein class D/0.441
2g263LGRenin3.4.23.150.441
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.441
2oreSAHDNA adenine methylase2.1.1.720.441
2p5uNADUDP-glucose 4-epimerase/0.441
2wo7ASVIsopenicillin N synthase1.21.3.10.441
2x7hPFNProstaglandin reductase 310.441
2x91LPRAngiotensin-converting enzyme3.4.15.10.441
2x9dITCTetracycline repressor protein class D/0.441
2y5s78HDihydropteroate synthase/0.441
2yozOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.441
3ansS38Bifunctional epoxide hydrolase 23.3.2.100.441
3biz61EWee1-like protein kinase2.7.10.20.441
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.441
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.441
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.441
3h3r14HCollagen type IV alpha-3-binding protein/0.441
3kb6NADD-lactate dehydrogenase/0.441
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.441
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
3pe2E1BCasein kinase II subunit alpha2.7.11.10.441
3pn4BB2Peptide deformylase 1B, chloroplastic/mitochondrial3.5.1.880.441
3r95ACOMccE protein/0.441
3rueNADUDP-N-acetylglucosamine 4-epimerase/0.441
3s8xE59Carbonic anhydrase 24.2.1.10.441
3sp9IL2Peroxisome proliferator-activated receptor delta/0.441
3tp0FO5HTH-type transcriptional regulator EthR/0.441
3tq8TOPDihydrofolate reductase/0.441
3zeiAWHO-acetylserine sulfhydrylase/0.441
3znqSS8D-amino-acid oxidase1.4.3.30.441
4c1fX8ZMetallo-beta-lactamase type 2/0.441
4if5ACOAlpha-tubulin N-acetyltransferase 1/0.441
4kqrVPPPeptidoglycan D,D-transpeptidase FtsI/0.441
4nu6NADPhosphonate dehydrogenase1.20.1.10.441
4rtsSAMDNA adenine methylase2.1.1.720.441
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.441
4wkbTDI5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/0.441
4ys22BAUncharacterized protein/0.441
5uviZMAAdenosine receptor A2a/0.441
1h63FMNPentaerythritol tetranitrate reductase/0.440
1j8qFMNFlavodoxin/0.440
1jqiFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial/0.440
1lb9DNQGlutamate receptor 2/0.440
1lgtBP3Biphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.440
1nlmUD1UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase/0.440
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
1s1pNAPAldo-keto reductase family 1 member C3/0.440
1tj2FADBifunctional protein PutA1.5.5.20.440
1x7hNDPPutative ketoacyl reductase1.3.10.440
1xm1GAHProthrombin3.4.21.50.440
2a5uQYTPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
2ohhFMNType A flavoprotein FprA10.440
2pswCOAN-alpha-acetyltransferase 50/0.440
2q5qKPVIndole-3-pyruvate decarboxylase4.1.1.740.440
2x90EALAngiotensin-converting enzyme3.4.15.10.440
2y882ERPhosphoribosyl isomerase A5.3.1.160.440
2yn8STUEphrin type-B receptor 42.7.10.10.440
2z50028Geranylgeranyl pyrophosphate synthase/0.440
3d8bADPFidgetin-like protein 13.6.40.440
3dejRXCCaspase-33.4.22.560.440
3h6k33TCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3il1B5DGlutamate receptor 2/0.440
3lz6A0DCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3tfyCOAN-alpha-acetyltransferase 502.3.10.440
3vi5M4MHematopoietic prostaglandin D synthase/0.440
3w0iO11Vitamin D3 receptor/0.440
3wthIM4Acetylcholine-binding protein/0.440
3zidGDPTubulin-like protein CetZ/0.440
4b1e6T6Beta-secretase 13.4.23.460.440
4baoMVFProthrombin3.4.21.50.440
4bfsZVSPantothenate kinase2.7.1.330.440
4du6GTPGTP cyclohydrolase 1/0.440
4eh9IRGMitogen-activated protein kinase 14/0.440
4fam0SZAldo-keto reductase family 1 member C3/0.440
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4i8vBHFCytochrome P450 1A11.14.14.10.440
4ia1BIVVitamin D3 receptor A/0.440
4kp71UQ1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic1.1.1.2670.440
4l23X6KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.440
4nh82LCHeat shock protein HSP 90-alpha/0.440
4oztP1AEcdysone receptor, putative/0.440
4usqFADPyridine nucleotide-disulfide oxidoreductase/0.440
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.440
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.440