sc-PDB

List of CHEMBLId :

This value allows a number of roughly comparable measures of half-maximal response concentration/potency/affinity to be compared on a negative logarithmic scale (e.g., an IC50 measurement of 1nM would have a pChEMBL value of 9).

Uniprot Annotation

Name:	Protein farnesyltransferase subunit beta
ID:	FNTB_HUMAN
AC:	P49356
Organism:	Homo sapiens
Reign:	Eukaryota
TaxID:	9606
EC Number:	2.5.1.58

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Chains:

Chain Name:	Percentage of Residues within binding site
A	16 %
B	84 %

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Ligand binding site composition:

B-Factor:	34.739
Number of residues:	44
Including
Standard Amino Acids:	42
Non Standard Amino Acids:	1
Water Molecules:	1
Cofactors:
Metals:	ZN

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Cavity properties

Ligandability	Volume (Å3)
0.882	1113.750

% Hydrophobic	% Polar
40.61	59.39
According to VolSite

HET Code:	CYS_VAL_LEU_SER_GER
Formula:	C17H32N4O6S
Molecular weight:	420.524 g/mol
DrugBank ID:	-
Buried Surface Area:	54.52 %
Polar Surface area:	214.09 Å2

Number of
H-Bond Acceptors:	7
H-Bond Donors:	6
Rings:	0
Aromatic rings:	0
Anionic atoms:	1
Cationic atoms:	1
Rule of Five Violation:	1
Rotatable Bonds:	12

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Mass center Coordinates

X	Y	Z
16.9799	132.824	-3.49385

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