sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2vr0 | HQO | Cytochrome c-type protein |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2vr0 | HQO | Cytochrome c-type protein | / | 1.000 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.529 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.528 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.520 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.519 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.514 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.514 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.512 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.511 | |
| 2zzn | SAM | tRNA (guanine(37)-N1)-methyltransferase Trm5b | 2.1.1.228 | 0.510 | |
| 5fe1 | 12Q | Histone acetyltransferase KAT2B | 2.3.1.48 | 0.509 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.507 | |
| 3fri | SAH | 16S rRNA methylase | / | 0.507 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.505 | |
| 3sr4 | TT8 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.503 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 1ve3 | SAM | Uncharacterized protein | / | 0.501 | |
| 3lpf | Z77 | Beta-glucuronidase | 3.2.1.31 | 0.501 | |
| 2a4x | BLM | Mitomycin-binding protein | / | 0.500 | |
| 1nbh | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.499 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.498 | |
| 3wt0 | ATP | Cell division protein FtsA | / | 0.498 | |
| 5icf | SAH | (S)-norcoclaurine 6-O-methyltransferase | / | 0.498 | |
| 3pbl | ETQ | D(3) dopamine receptor | / | 0.498 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.496 | |
| 1t13 | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | / | 0.494 | |
| 3dhc | CYK | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.494 | |
| 4isu | IKM | Glutamate receptor 2 | / | 0.494 | |
| 3mte | SAM | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.492 | |
| 4m48 | 21B | Sodium-dependent dopamine transporter | / | 0.492 | |
| 3ny8 | JRZ | Beta-2 adrenergic receptor | / | 0.492 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.491 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.490 | |
| 1nw3 | SAM | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.489 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.488 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.488 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.487 | |
| 4f1y | CNI | Glutamate receptor 3 | / | 0.487 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.487 | |
| 1sg9 | SAM | Release factor glutamine methyltransferase | 2.1.1.297 | 0.486 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.486 | |
| 2obx | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | 2.5.1.78 | 0.486 | |
| 3b9o | FMN | Alkane monoxygenase | / | 0.486 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.485 | |
| 3vye | VYE | Renin | 3.4.23.15 | 0.485 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.484 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.484 | |
| 3sm0 | AEK | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.484 | |
| 1nv8 | SAM | Release factor glutamine methyltransferase | 2.1.1.297 | 0.483 | |
| 3reo | SAH | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.483 | |
| 2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.482 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.482 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
| 1d2s | DHT | Sex hormone-binding globulin | / | 0.481 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.480 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.480 | |
| 1e2n | RCA | Thymidine kinase | / | 0.479 | |
| 1f28 | F89 | Thymidylate synthase | 2.1.1.45 | 0.479 | |
| 1j8u | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.479 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.479 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.479 | |
| 5kbw | RBF | Riboflavin transporter RibU | / | 0.479 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.478 | |
| 2w5b | AGS | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.478 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.478 | |
| 4xz3 | COA | Acyl-CoA synthetase (NDP forming) | / | 0.478 | |
| 1tsd | F89 | Thymidylate synthase | / | 0.477 | |
| 2bsx | NOS | Purine nucleoside phosphorylase | / | 0.477 | |
| 3pdn | SFG | Histone-lysine N-methyltransferase SMYD3 | 2.1.1.43 | 0.477 | |
| 3wqt | ANP | Cell division protein FtsA | / | 0.477 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.476 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.475 | |
| 1gpe | FAD | Glucose oxidase | 1.1.3.4 | 0.475 | |
| 1i2l | DCS | Aminodeoxychorismate lyase | 4.1.3.38 | 0.475 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.475 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.475 | |
| 2oz5 | 7XY | Uncharacterized protein | / | 0.475 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.475 | |
| 2xkd | T3M | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.475 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.475 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.475 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.475 | |
| 1n77 | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.474 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.474 | |
| 5f2k | SAH | Uncharacterized protein | / | 0.474 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.474 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.473 | |
| 2wba | FAD | Trypanothione reductase | 1.8.1.12 | 0.473 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1afe | ALZ | Prothrombin | 3.4.21.5 | 0.471 | |
| 1dlj | UGA | UDP-glucose 6-dehydrogenase | / | 0.471 | |
| 1uxu | NAP | NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase | / | 0.471 | |
| 1w7h | 3IP | Mitogen-activated protein kinase 14 | / | 0.471 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.471 | |
| 2xke | WI2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.471 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.471 | |
| 3bbf | GDP | Nucleoside diphosphate kinase B | 2.7.4.6 | 0.471 | |
| 4pb2 | 5UD | Nucleoside permease | / | 0.471 | |
| 4uy6 | SAH | Histidine N-alpha-methyltransferase | / | 0.471 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 2d4h | 5GP | Guanylate-binding protein 1 | / | 0.470 | |
| 2owb | 626 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.470 | |
| 3h4v | NAP | Pteridine reductase 1 | 1.5.1.33 | 0.470 | |
| 3vyw | SAM | Uncharacterized protein | / | 0.470 | |
| 4bmp | FMN | Protein NrdI | / | 0.470 | |
| 4gg9 | 0WW | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.470 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.469 | |
| 2xiq | 5AD | Methylmalonyl-CoA mutase, mitochondrial | / | 0.469 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.469 | |
| 3i53 | SAH | 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase | / | 0.469 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.469 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.469 | |
| 4ug7 | 1EV | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.469 | |
| 1fx9 | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.468 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.468 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.468 | |
| 2clf | F6F | Tryptophan synthase alpha chain | / | 0.468 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.468 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.468 | |
| 3el7 | PD3 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.468 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.468 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.468 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.467 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.467 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.467 | |
| 3p9t | TCL | Repressor | / | 0.467 | |
| 3wqu | ATP | Cell division protein FtsA | / | 0.467 | |
| 4l43 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.467 | |
| 1lvu | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.466 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.466 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.466 | |
| 3jq6 | DX1 | Pteridine reductase, putative | / | 0.466 | |
| 1kuv | CA5 | Serotonin N-acetyltransferase | / | 0.465 | |
| 1tyt | FAD | Trypanothione reductase | 1.8.1.12 | 0.465 | |
| 1wkl | ATP | Nucleoside diphosphate kinase | / | 0.465 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.465 | |
| 4bz7 | B3N | Histone deacetylase | / | 0.465 | |
| 4c6z | TLE | 3-oxoacyl-ACP synthase | / | 0.465 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.465 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.465 | |
| 1fxf | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.464 | |
| 1qw5 | 14W | Nitric oxide synthase, inducible | 1.14.13.39 | 0.464 | |
| 2o98 | FSC | 14-3-3-like protein C | / | 0.464 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.464 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.464 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.464 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 4biw | ANP | Sensor histidine kinase CpxA | / | 0.464 | |
| 4py6 | R78 | Bromodomain protein, putative | / | 0.464 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.464 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1kuy | COT | Serotonin N-acetyltransferase | / | 0.463 | |
| 1lud | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1owp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.463 | |
| 2gzl | 2AA | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 4.6.1.12 | 0.463 | |
| 4beb | ATP | Type I restriction enzyme EcoR124II R protein | 3.1.21.3 | 0.463 | |
| 4ec3 | REN | Reticuline oxidase | 1.21.3.3 | 0.463 | |
| 1qpb | TPP | Pyruvate decarboxylase isozyme 1 | / | 0.462 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.462 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.462 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.462 | |
| 3p2k | SAM | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.462 | |
| 3rth | RTH | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 4ivq | I43 | Thymidine kinase | / | 0.462 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.462 | |
| 1jdz | FMB | Purine nucleoside phosphorylase | / | 0.461 | |
| 1wnb | NAI | Gamma-aminobutyraldehyde dehydrogenase | 1.2.1.19 | 0.461 | |
| 2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.461 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.461 | |
| 2xk4 | OL2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.461 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.461 | |
| 3x02 | 5GP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.461 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.461 | |
| 1jdt | MTA | Purine nucleoside phosphorylase | / | 0.460 | |
| 1nv9 | SAH | Release factor glutamine methyltransferase | 2.1.1.297 | 0.460 | |
| 3l7g | M44 | Xaa-Pro dipeptidase | 3.4.13.9 | 0.460 | |
| 3n62 | XFJ | Nitric oxide synthase, brain | 1.14.13.39 | 0.460 | |
| 3qpv | ADP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 2.7.1.105 | 0.460 | |
| 3rhl | NAP | Cytosolic 10-formyltetrahydrofolate dehydrogenase | 1.5.1.6 | 0.460 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.460 | |
| 3nya | JTZ | Beta-2 adrenergic receptor | / | 0.460 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.459 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.459 | |
| 2x9v | TMQ | Pteridine reductase | / | 0.459 | |
| 3dhb | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.459 | |
| 3juq | AKD | Phenazine biosynthesis protein A/B | / | 0.459 | |
| 3pd2 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.459 | |
| 3qdz | PRO_ALA_PRO_ARG | Prothrombin | 3.4.21.5 | 0.459 | |
| 3qvw | NAD | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.459 | |
| 3uxv | GUN | NADPH-dependent 7-cyano-7-deazaguanine reductase | / | 0.459 | |
| 4req | 5AD | Methylmalonyl-CoA mutase large subunit | 5.4.99.2 | 0.459 | |
| 5jqh | CAU | Beta-2 adrenergic receptor | / | 0.459 | |
| 3d4s | TIM | Beta-2 adrenergic receptor | / | 0.459 | |
| 1u1d | 181 | Uridine phosphorylase | 2.4.2.3 | 0.458 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.458 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.458 | |
| 3mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.458 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.458 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.458 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1ja1 | FMN | NADPH--cytochrome P450 reductase | / | 0.457 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.457 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.457 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.457 | |
| 2f99 | AKV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.457 | |
| 2r7n | ADP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase | / | 0.457 | |
| 2w0h | FAD | Trypanothione reductase | / | 0.457 | |
| 3bhr | THG | Thymidylate synthase | / | 0.457 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 4ek9 | EP4 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.457 | |
| 4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.457 | |
| 4fr1 | 0V2 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.457 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.456 | |
| 1ia9 | ANP | Transient receptor potential cation channel subfamily M member 7 | 2.7.11.1 | 0.456 | |
| 1m9k | 7NI | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.456 | |
| 2xnp | WCX | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.456 | |
| 2zrz | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.456 | |
| 3kmy | D8Y | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 3p9k | SAH | Caffeic acid O-methyltransferase | / | 0.456 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.456 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.456 | |
| 4f1m | ACP | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 | 0.456 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.456 | |
| 4ug9 | 1EW | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.456 | |
| 5ex0 | SAH | Histone-lysine N-methyltransferase SMYD3 | 2.1.1.43 | 0.456 | |
| 2a2x | NA9 | Prothrombin | 3.4.21.5 | 0.455 | |
| 2nm2 | NEU | Dihydroneopterin aldolase | / | 0.455 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.455 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 3oxf | SAH | Histone-lysine N-methyltransferase SMYD3 | 2.1.1.43 | 0.455 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.455 | |
| 4bgb | ADP | Predicted molecular chaperone distantly related to HSP70-fold metalloproteases | / | 0.455 | |
| 4isg | 1FY | Glucokinase | 2.7.1.2 | 0.455 | |
| 4pl9 | ADP | Ethylene receptor 1 | / | 0.455 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.455 | |
| 1gnw | GTX | Glutathione S-transferase F2 | 2.5.1.18 | 0.454 | |
| 1gxf | FAD | Trypanothione reductase | 1.8.1.12 | 0.454 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.454 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 2gfs | PQB | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.454 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.454 | |
| 2oc4 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 2y88 | 2ER | Phosphoribosyl isomerase A | 5.3.1.16 | 0.454 | |
| 3png | 8CX | Nitric oxide synthase, brain | 1.14.13.39 | 0.454 | |
| 3rhr | NDP | Cytosolic 10-formyltetrahydrofolate dehydrogenase | 1.5.1.6 | 0.454 | |
| 3vo2 | FAD | Ferredoxin--NADP reductase | / | 0.454 | |
| 4h1j | 0YH | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.454 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4qnu | GEK | tRNA U34 carboxymethyltransferase | / | 0.454 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.454 | |
| 4uyg | 73B | Bromodomain-containing protein 2 | / | 0.454 | |
| 5dst | SAH | Protein arginine N-methyltransferase 8 | 2.1.1 | 0.454 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.454 | |
| 1g7v | PAI | 2-dehydro-3-deoxyphosphooctonate aldolase | 2.5.1.55 | 0.453 | |
| 1jsc | FAD | Acetolactate synthase catalytic subunit, mitochondrial | 2.2.1.6 | 0.453 | |
| 1mvc | BM6 | Retinoic acid receptor RXR-alpha | / | 0.453 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2aqb | TL6 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.453 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.453 | |
| 2ipj | FFA | Aldo-keto reductase family 1 member C2 | / | 0.453 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.453 | |
| 2wd8 | VGF | Pteridine reductase | / | 0.453 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.453 | |
| 3dej | RXC | Caspase-3 | 3.4.22.56 | 0.453 | |
| 4dcm | SAM | Ribosomal RNA large subunit methyltransferase G | 2.1.1.174 | 0.453 | |
| 4gh1 | 0WX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.453 | |
| 4id9 | NAD | Putative UDP-glucose 4-epimerase | / | 0.453 | |
| 4kvz | SAH | PtnL protein | / | 0.453 | |
| 4l7g | 1W0 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 4rrh | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.453 | |
| 4s1i | PLP | Pyridoxal kinase, putative | / | 0.453 | |
| 1owo | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.452 | |
| 1rp7 | TZD | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.452 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.452 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.452 | |
| 2g27 | 4LG | Renin | 3.4.23.15 | 0.452 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.452 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.452 | |
| 2hp2 | KE4 | Glutamate-1-semialdehyde 2,1-aminomutase | 5.4.3.8 | 0.452 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.452 | |
| 2vro | NDP | 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase | / | 0.452 | |
| 3acy | 702 | Dehydrosqualene synthase | / | 0.452 | |
| 3lcu | SAH | 16S rRNA (guanine(1405)-N(7))-methyltransferase | 2.1.1.179 | 0.452 | |
| 3qow | SAM | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.452 | |
| 4b70 | WM9 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4ctj | SAM | Genome polyprotein | / | 0.452 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.452 | |
| 4frj | DWB | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4g56 | SAH | Protein arginine N-methyltransferase 5 | / | 0.452 | |
| 4kdr | SAH | Ubiquinone biosynthesis O-methyltransferase | / | 0.452 | |
| 4m8e | 29V | Retinoic acid receptor RXR-alpha | / | 0.452 | |
| 4oe4 | NAD | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | 1.2.1.88 | 0.452 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.452 | |
| 1c7o | PPG | Hemolysin | / | 0.451 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.451 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.451 | |
| 2v57 | PRL | TetR family transcriptional regulator | / | 0.451 | |
| 2wqo | VGK | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.451 | |
| 3c34 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.451 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.451 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.451 | |
| 3nbz | GTP | GTP-binding nuclear protein Ran | / | 0.451 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.451 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.451 | |
| 4k6i | 9RA | Retinoic acid receptor RXR-alpha | / | 0.451 | |
| 4uog | YYY | Nucleoside diphosphate kinase | / | 0.451 | |
| 4uoh | ADP | Nucleoside diphosphate kinase | / | 0.451 | |
| 1d9i | 00P | Prothrombin | 3.4.21.5 | 0.450 | |
| 1pr4 | MTP | Purine nucleoside phosphorylase DeoD-type | / | 0.450 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.450 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.450 | |
| 2anm | CDO | Prothrombin | 3.4.21.5 | 0.450 | |
| 2bkt | RPF | Renin | 3.4.23.15 | 0.450 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.450 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.450 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 4h0y | NAD | Iota toxin component Ia | / | 0.450 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.450 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 1giq | NAI | Iota toxin component Ia | / | 0.449 | |
| 1jdv | ADN | Purine nucleoside phosphorylase | / | 0.449 | |
| 1l8a | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.449 | |
| 1mzn | BM6 | Retinoic acid receptor RXR-alpha | / | 0.449 | |
| 1rvv | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.449 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.449 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.449 | |
| 1w19 | T1P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.449 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.449 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 2xkc | 4VQ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.449 | |
| 3b5i | SAH | Indole-3-acetate O-methyltransferase 1 | / | 0.449 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4djx | 0KQ | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4gmg | NAP | Yersiniabactin biosynthetic protein YbtU | / | 0.449 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.449 | |
| 5fa8 | SAM | Ribosomal protein L11 methyltransferase, putative | / | 0.449 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.448 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.448 | |
| 1o5g | CR9 | Prothrombin | 3.4.21.5 | 0.448 | |
| 1riw | OSC | Prothrombin | 3.4.21.5 | 0.448 | |
| 1vq1 | SAM | Release factor glutamine methyltransferase | 2.1.1.297 | 0.448 | |
| 1vzq | SHY | Prothrombin | 3.4.21.5 | 0.448 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 2cdc | NAP | Glucose 1-dehydrogenase | / | 0.448 | |
| 2gtb | AZP | Orf1ab polyprotein | / | 0.448 | |
| 2ovh | AS0 | Progesterone receptor | / | 0.448 | |
| 2p1t | 3TN | Retinoic acid receptor RXR-alpha | / | 0.448 | |
| 2xf3 | J01 | Uncharacterized protein | / | 0.448 | |
| 3b7d | CNI | Glutamate receptor 2 | / | 0.448 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3ohf | 3HF | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3qbw | ADP | Anhydro-N-acetylmuramic acid kinase | / | 0.448 | |
| 3up0 | D7S | aceDAF-12 | / | 0.448 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.448 | |
| 4c43 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.448 | |
| 4cx4 | HW9 | Nitric oxide synthase, brain | 1.14.13.39 | 0.448 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.448 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4ktt | SAM | S-adenosylmethionine synthase isoform type-2 | 2.5.1.6 | 0.448 | |
| 4nbn | 2J7 | Caspase-6 | 3.4.22.59 | 0.448 | |
| 4rri | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.448 | |
| 4ts7 | ADP | Purine phosphoribosyltransferase (GpT-1) | / | 0.448 | |
| 5hq8 | SAH | Histone-lysine N-methyltransferase SMYD3 | 2.1.1.43 | 0.448 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.448 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.447 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.447 | |
| 2bf4 | FAD | NADPH--cytochrome P450 reductase | / | 0.447 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.447 | |
| 2rjp | 886 | A disintegrin and metalloproteinase with thrombospondin motifs 4 | 3.4.24.82 | 0.447 | |
| 2woe | AR6 | ADP-ribosyl-[dinitrogen reductase] glycohydrolase | 3.2.2.24 | 0.447 | |
| 2z78 | H86 | Geranylgeranyl pyrophosphate synthase | / | 0.447 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.447 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 3k5d | XLI | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.447 | |
| 3nta | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.447 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.447 | |
| 4a3u | FMN | NADH:flavin oxidoreductase/NADH oxidase | / | 0.447 | |
| 4fs4 | H24 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.447 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.447 | |
| 4kwc | SAH | Methyltransferase domain family | / | 0.447 | |
| 4pkl | 1GH | Uncharacterized protein | / | 0.447 | |
| 4rrw | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.447 | |
| 4rrz | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.447 | |
| 4rwn | APC | 2'-5'-oligoadenylate synthase 1 | 2.7.7.84 | 0.447 | |
| 1c4y | IH3 | Prothrombin | 3.4.21.5 | 0.446 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.446 | |
| 1jf7 | TBH | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.446 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 1xh6 | R94 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 1ypj | UIB | Prothrombin | 3.4.21.5 | 0.446 | |
| 2h94 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.446 | |
| 2hko | FAD | Lysine-specific histone demethylase 1A | 1 | 0.446 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.446 | |
| 2oat | PFM | Ornithine aminotransferase, mitochondrial | 2.6.1.13 | 0.446 | |
| 2on6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.446 | |
| 2xvv | 9DN | Serum albumin | / | 0.446 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.446 | |
| 3ngl | NAP | Bifunctional protein FolD | / | 0.446 | |
| 3q87 | SAM | N6 ADENINE SPECIFIC DNA METHYLASE (METHYLTRANSFERASE SUPERFAMILY) | / | 0.446 | |
| 3qtv | 06P | Prothrombin | 3.4.21.5 | 0.446 | |
| 3qvr | FAD | Glucose oxidase | 1.1.3.4 | 0.446 | |
| 3x1d | GDP | Atlastin | 3.6.5 | 0.446 | |
| 4bec | ATP | Type I restriction enzyme EcoR124II R protein | 3.1.21.3 | 0.446 | |
| 4dan | 2FA | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.446 | |
| 4ehv | 0SJ | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.446 | |
| 4fw0 | 5KJ | Nitric oxide synthase, brain | 1.14.13.39 | 0.446 | |
| 4ndn | SAM | S-adenosylmethionine synthase isoform type-2 | 2.5.1.6 | 0.446 | |
| 5dbj | FAD | FADH2-dependent halogenase PltA | / | 0.446 | |
| 1a4i | NDP | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.445 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.445 | |
| 1gaq | FAD | Ferredoxin | / | 0.445 | |
| 1ofv | FMN | Flavodoxin | / | 0.445 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.445 | |
| 2wp5 | FAD | Trypanothione reductase | / | 0.445 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4c36 | ZO9 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 4dmg | SAM | Uncharacterized protein | / | 0.445 | |
| 4f0f | ACP | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 | 0.445 | |
| 4f9b | 0SY | Cell division cycle 7-related protein kinase | 2.7.11.1 | 0.445 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 4glx | 0XS | DNA ligase | 6.5.1.2 | 0.445 | |
| 4jse | QJ2 | Nitric oxide synthase, brain | 1.14.13.39 | 0.445 | |
| 4l7j | 1W2 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4lg5 | A1O | Abscisic acid receptor PYL2 | / | 0.445 | |
| 4lrr | CF9 | Thymidylate synthase | / | 0.445 | |
| 4mk7 | 28O | Genome polyprotein | 2.7.7.48 | 0.445 | |
| 4y3q | F02 | Endothiapepsin | 3.4.23.22 | 0.445 | |
| 4yx6 | FMN | Omega-3 polyunsaturated fatty acid synthase subunit PfaD | / | 0.445 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.445 | |
| 1cde | GAR | Phosphoribosylglycinamide formyltransferase | / | 0.444 | |
| 1k7f | IAV | Tryptophan synthase alpha chain | / | 0.444 | |
| 1og1 | TAD | T-cell ecto-ADP-ribosyltransferase 2 | / | 0.444 | |
| 1qs2 | NAD | Vip2Ac | / | 0.444 | |
| 1u1c | BAU | Uridine phosphorylase | 2.4.2.3 | 0.444 | |
| 1xmm | M7G | m7GpppX diphosphatase | 3.6.1.59 | 0.444 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2f6r | ACO | Bifunctional coenzyme A synthase | / | 0.444 | |
| 2g1a | 5HG | Class B acid phosphatase | 3.1.3.2 | 0.444 | |
| 2qwq | ADP | Heat shock cognate 71 kDa protein | / | 0.444 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.444 | |
| 3ab1 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.444 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3q2j | CKI | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.444 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.444 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.444 | |
| 4afe | GGY | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.444 | |
| 4da8 | BG2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.444 | |
| 4fwj | FAD | Lysine-specific histone demethylase 1B | 1 | 0.444 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4y3z | F41 | Endothiapepsin | 3.4.23.22 | 0.444 | |
| 4zhi | ADP | Kinesin-like protein KIF11 | / | 0.444 | |
| 5ahs | COA | Acyl-CoA dehydrogenase | / | 0.444 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.444 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 1fec | FAD | Trypanothione reductase | 1.8.1.12 | 0.443 | |
| 1fml | RTL | Retinol dehydratase | / | 0.443 | |
| 1kia | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.443 | |
| 1kyz | FER | Caffeic acid 3-O-methyltransferase | 2.1.1.68 | 0.443 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.443 | |
| 1sui | SAH | Caffeoyl-CoA O-methyltransferase | 2.1.1.104 | 0.443 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.443 | |
| 1uk0 | FRM | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.443 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.443 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.443 | |
| 2gby | BRN | HTH-type transcriptional regulator QacR | / | 0.443 | |
| 2h21 | SAM | Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic | 2.1.1.127 | 0.443 | |
| 2ohj | FMN | Type A flavoprotein FprA | 1 | 0.443 | |
| 2pmn | K51 | Protein kinase 7 | / | 0.443 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.443 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.443 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 3fkn | FKN | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3fl4 | FL4 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3g5i | DNB | Pyrimidine-specific ribonucleoside hydrolase RihA | / | 0.443 | |
| 3n71 | SFG | Histone-lysine N-methyltransferase Smyd1 | / | 0.443 | |
| 3wst | SAH | Protein arginine N-methyltransferase 7 | 2.1.1 | 0.443 | |
| 4azy | 7F3 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.443 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4eil | UMP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.443 | |
| 4jbx | SK7 | Thymidine kinase | / | 0.443 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.443 | |
| 4u3j | GTP | Tubulin beta chain | / | 0.443 | |
| 5dqr | FAD | 7-hydroxymethyl chlorophyll a reductase, chloroplastic | 1.17.7.2 | 0.443 | |
| 2ycy | P32 | Beta-1 adrenergic receptor | / | 0.443 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.442 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1l0c | COT | Serotonin N-acetyltransferase | / | 0.442 | |
| 1lbb | KAI | Glutamate receptor 2 | / | 0.442 | |
| 1n2v | BDI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.442 | |
| 1pfy | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.442 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.442 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.442 | |
| 2f8l | SAM | Lmo1582 protein | / | 0.442 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2r6h | FAD | Na(+)-translocating NADH-quinone reductase subunit F | / | 0.442 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3c36 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.442 | |
| 3c3e | GDP | 2-phospho-L-lactate transferase | / | 0.442 | |
| 3c4v | LIP | D-inositol 3-phosphate glycosyltransferase | 2.4.1.250 | 0.442 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.442 | |
| 3ge7 | AFQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.442 | |
| 3hwx | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.442 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3n61 | XFJ | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 3ncz | 3NC | Rho-associated protein kinase 1 | 2.7.11.1 | 0.442 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.442 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.442 | |
| 3qfc | NAP | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 3r6c | 17N | Anthranilate phosphoribosyltransferase | / | 0.442 | |
| 3veu | 0GO | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 3wth | IM4 | Acetylcholine-binding protein | / | 0.442 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 4acu | QN7 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4bub | ADP | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase | / | 0.442 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.442 | |
| 4dc3 | 2FA | Putative adenosine kinase | / | 0.442 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 4h3g | 10Q | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.442 | |
| 5dr6 | SKE | Aurora kinase A | 2.7.11.1 | 0.442 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.441 | |
| 1e2j | THM | Thymidine kinase | / | 0.441 | |
| 1gax | VAA | Valine--tRNA ligase | 6.1.1.9 | 0.441 | |
| 1qsr | ACO | HAT A1 | / | 0.441 | |
| 1w1r | ZEA | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.441 | |
| 2b82 | ADN | Class B acid phosphatase | 3.1.3.2 | 0.441 | |
| 2egl | SAH | Diphthine synthase | / | 0.441 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 3btj | DEQ | HTH-type transcriptional regulator QacR | / | 0.441 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.441 | |
| 3o8a | O8A | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.441 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.441 | |
| 3thr | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.441 | |
| 3w6u | NAP | 6-phosphogluconate dehydrogenase, NAD-binding protein | / | 0.441 | |
| 4dxl | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.441 | |
| 4f31 | KAI | Glutamate receptor 3 | / | 0.441 | |
| 4h6p | FMN | Chromate reductase | / | 0.441 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4mmc | 29J | Na(+):neurotransmitter symporter (Snf family) | / | 0.441 | |
| 4ubv | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.441 | |
| 4x81 | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.441 | |
| 1cjv | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cjv | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.440 | |
| 1e7a | PFL | Serum albumin | / | 0.440 | |
| 1gt5 | BZQ | Odorant-binding protein | / | 0.440 | |
| 1je1 | GMP | Purine nucleoside phosphorylase | / | 0.440 | |
| 1pg0 | MOD | Methionine--tRNA ligase | 6.1.1.10 | 0.440 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.440 | |
| 1qzz | SAM | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.440 | |
| 1suw | NAP | NAD kinase | / | 0.440 | |
| 1tww | HH2 | Dihydropteroate synthase | / | 0.440 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.440 | |
| 2eg5 | SAH | 7-methylxanthosine synthase 1 | / | 0.440 | |
| 2ejz | SAH | Diphthine synthase | / | 0.440 | |
| 2f4j | VX6 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.440 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.440 | |
| 2i62 | SAH | Nicotinamide N-methyltransferase | 2.1.1.1 | 0.440 | |
| 2rab | NAD | Glutathione amide reductase | / | 0.440 | |
| 2v34 | CTN | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.440 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2zfq | 45U | Prothrombin | 3.4.21.5 | 0.440 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.440 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 3fzf | ATP | Heat shock cognate 71 kDa protein | / | 0.440 | |
| 3gxo | SAH | Mitomycin biosynthesis 6-O-methyltransferase | / | 0.440 | |
| 3isj | A8D | Pantothenate synthetase | 6.3.2.1 | 0.440 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.440 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.440 | |
| 3ufp | H4W | Nitric oxide synthase, brain | 1.14.13.39 | 0.440 | |
| 3zmg | 6Z0 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4aoi | 4K0 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.440 | |
| 4b05 | 32D | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.440 | |
| 4kx6 | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.440 | |
| 4na4 | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.440 | |
| 4o4e | ATP | Kinase | / | 0.440 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.440 | |
| 4trj | 665 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4xp1 | LDP | Sodium-dependent dopamine transporter | / | 0.440 | |
| 5jr3 | SAH | Carminomycin 4-O-methyltransferase DnrK | 2.1.1.292 | 0.440 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.440 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.440 |