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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ah0SBIAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ah0SBIAldose reductase1.1.1.211.000
1ekoI84Aldose reductase1.1.1.210.699
2pdkSBIAldose reductase1.1.1.210.655
3u2cSUZAldose reductase1.1.1.210.643
2inzOHPAldose reductase1.1.1.210.634
2nvcITAAldose reductase1.1.1.210.633
1ef3FIDAldose reductase1.1.1.210.626
2pdwFIDAldose reductase1.1.1.210.623
2f2kTGGAldose reductase1.1.1.210.622
2pdyFIDAldose reductase1.1.1.210.621
1pwmFIDAldose reductase1.1.1.210.616
2is72CLAldose reductase1.1.1.210.616
5liu388Aldo-keto reductase family 1 member B101.1.10.615
4gabFIDAldo-keto reductase family 1 member B101.1.10.612
1el3I84Aldose reductase1.1.1.210.611
4wevSUZAldo-keto reductase family 1 member B101.1.10.611
3s3gTLTAldose reductase1.1.1.210.594
2pd9FIDAldose reductase1.1.1.210.580
2pdfZSTAldose reductase1.1.1.210.577
3p2vDOYAldose reductase1.1.1.210.570
2hvnZSTAldose reductase1.1.1.210.568
2iqdLPAAldose reductase1.1.1.210.555
2agtFIDAldose reductase1.1.1.210.554
2pdlTOLAldose reductase1.1.1.210.550
2ikj393Aldose reductase1.1.1.210.547
4ga8SBIAldo-keto reductase family 1 member B101.1.10.547
2fz8ZSTAldose reductase1.1.1.210.545
2pdh47DAldose reductase1.1.1.210.545
2pdj393Aldose reductase1.1.1.210.544
2pzn393Aldose reductase1.1.1.210.544
3g5eQ74Aldose reductase1.1.1.210.541
3ghsLDTAldose reductase1.1.1.210.540
1z3n3NAAldose reductase1.1.1.210.538
1ieiZESAldose reductase1.1.1.210.535
2fzbTOLAldose reductase1.1.1.210.535
2iki388Aldose reductase1.1.1.210.534
3ghrLDTAldose reductase1.1.1.210.532
2duxZSTAldose reductase1.1.1.210.530
3v35NTIAldose reductase1.1.1.210.530
1hfrMOTDihydrofolate reductase1.5.1.30.529
1pwlBFIAldose reductase1.1.1.210.528
2dv0ZSTAldose reductase1.1.1.210.528
2pdu393Aldose reductase1.1.1.210.528
3m4h388Aldose reductase1.1.1.210.528
3m64393Aldose reductase1.1.1.210.528
1t41ID5Aldose reductase1.1.1.210.526
2pdq47DAldose reductase1.1.1.210.525
2i16LDTAldose reductase1.1.1.210.524
2i17LDTAldose reductase1.1.1.210.524
1t40ID5Aldose reductase1.1.1.210.522
3ghuLDTAldose reductase1.1.1.210.520
2bjsACVIsopenicillin N synthase1.21.3.10.519
1us0LDTAldose reductase1.1.1.210.516
2fzdTOLAldose reductase1.1.1.210.515
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.514
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.512
3lboLDTAldose reductase1.1.1.210.511
1ah3TOLAldose reductase1.1.1.210.509
3ld5LDTAldose reductase1.1.1.210.509
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.508
2hvoZSTAldose reductase1.1.1.210.507
4kfjFOLDihydrofolate reductase1.5.1.30.507
2qxwLDTAldose reductase1.1.1.210.506
1zq5E04Aldo-keto reductase family 1 member C3/0.505
3gyf51PDihydrofolate reductase1.5.1.30.503
4gca2X9Aldose reductase1.1.1.210.503
2duzZSTAldose reductase1.1.1.210.501
2fz9ZSTAldose reductase1.1.1.210.501
2pdc393Aldose reductase1.1.1.210.501
2pdp393Aldose reductase1.1.1.210.501
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.500
1frbZSTAldose reductase-related protein 2/0.499
3lz5LDTAldose reductase1.1.1.210.499
3lenZSTAldose reductase1.1.1.210.498
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.497
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.497
3cv7C2UAlcohol dehydrogenase [NADP(+)]1.1.1.20.496
4bfwZVWPantothenate kinase2.7.1.330.496
4m6kFOLDihydrofolate reductase1.5.1.30.496
2xlpNAPPutative flavin-containing monooxygenase/0.495
2g263LGRenin3.4.23.150.494
4lm4JPZcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.494
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.493
4kn104JFolate receptor beta/0.493
2hv5ZSTAldose reductase1.1.1.210.492
2ipw2CLAldose reductase1.1.1.210.492
1kmsLIHDihydrofolate reductase1.5.1.30.491
1ohjCOPDihydrofolate reductase1.5.1.30.491
1ry8RUTAldo-keto reductase family 1 member C3/0.491
5cxv0HKMuscarinic acetylcholine receptor M1/0.491
2j7cIDEBeta-glucosidase A3.2.1.210.490
2pdxZSTAldose reductase1.1.1.210.490
3uyk0CXProbable NDP-rhamnosyltransferase/0.490
1u70MTXDihydrofolate reductase1.5.1.30.489
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.489
2f3815MAldo-keto reductase family 1 member C3/0.488
3nu03TUDihydrofolate reductase1.5.1.30.488
3t423T4Aldose reductase1.1.1.210.488
1w6jR71Lanosterol synthase5.4.99.70.487
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.487
3r8hZOMAldo-keto reductase family 1 member C3/0.487
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.486
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.486
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.486
4kebFOLDihydrofolate reductase1.5.1.30.486
1z8962PAldose reductase1.1.1.210.485
3v0p4GWHisto-blood group ABO system transferase/0.485
2wgs1AZGlutamine synthetase6.3.1.20.484
3q9bB3NAcetylpolyamine amidohydrolase/0.484
1ry0PG2Aldo-keto reductase family 1 member C3/0.483
3r8gIZPAldo-keto reductase family 1 member C3/0.483
2pd5ZSTAldose reductase1.1.1.210.482
2vqqTFGHistone deacetylase 43.5.1.980.482
3b82NADExotoxin A2.4.2.360.482
3burTES3-oxo-5-beta-steroid 4-dehydrogenase/0.482
3c3xNAPEugenol synthase 11.1.1.3180.482
3mb9ZSTAldose reductase1.1.1.210.482
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.482
1sg0STLRibosyldihydronicotinamide dehydrogenase [quinone]/0.480
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.480
4jvlESTEstrogen sulfotransferase2.8.2.40.480
1dlsMTXDihydrofolate reductase1.5.1.30.479
4fam0SZAldo-keto reductase family 1 member C3/0.479
4jq4IMNAldo-keto reductase family 1 member C2/0.479
4kn0MTXFolate receptor beta/0.479
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.478
4u140HKMuscarinic acetylcholine receptor M3/0.478
1hb1OCVIsopenicillin N synthase1.21.3.10.477
2hzqSTRApolipoprotein D/0.477
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.477
3n61H4BNitric oxide synthase, brain1.14.13.390.477
3rl45GPMetallophosphoesterase MPPED23.10.477
3zkuHCVIsopenicillin N synthase1.21.3.10.477
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.477
5stdUNNScytalone dehydratase4.2.1.940.477
1d3dBZTProthrombin3.4.21.50.476
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.476
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.476
2ikhLITAldose reductase1.1.1.210.476
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.476
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.476
4lcw1VYMajor histocompatibility complex class I-related gene protein/0.476
4paaTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.476
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.475
2ycyP32Beta-1 adrenergic receptor/0.475
2wo7ASVIsopenicillin N synthase1.21.3.10.474
3h4gFIDAlcohol dehydrogenase [NADP(+)]1.1.1.20.474
3k4551PDihydrofolate reductase1.5.1.30.474
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.474
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.474
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.473
1rxjBNIStreptavidin/0.473
1xf0ASDAldo-keto reductase family 1 member C3/0.473
2aot2PMHistamine N-methyltransferase2.1.1.80.473
2e82IM3D-amino-acid oxidase1.4.3.30.473
2pdn47DAldose reductase1.1.1.210.473
2vbdV10Isopenicillin N synthase1.21.3.10.473
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.600.473
3l3rOAGDihydrofolate reductase1.5.1.30.473
3ug8IMNAldo-keto reductase family 1 member C3/0.473
3voiRCBGlucanase/0.473
7catNDPCatalase1.11.1.60.473
1pd8CO4Dihydrofolate reductase1.5.1.30.472
1qiqACCIsopenicillin N synthase1.21.3.10.472
1sm4FADFerredoxin--NADP reductase/0.472
2f98NGVAklanonic acid methyl ester cyclase AcmA5.5.1.230.472
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.472
4dz5NAPAldo-keto reductase family 1 member C3/0.472
4kn2LYAFolate receptor beta/0.472
1h22E10Acetylcholinesterase3.1.1.70.471
1o1t2NHProtein farnesyltransferase subunit beta2.5.1.580.471
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.471
4dbs0HVAldo-keto reductase family 1 member C3/0.471
4hkiFLNTankyrase-22.4.2.300.471
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.471
1h66RH1NAD(P)H dehydrogenase [quinone] 11.6.5.20.470
1isgAGSADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 23.2.2.60.470
1kyyINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.470
1z4iUMP5'(3')-deoxyribonucleotidase, mitochondrial3.1.30.470
2fs4PZ1Renin3.4.23.150.470
2vqbNAPPutative flavin-containing monooxygenase/0.470
2xltNA0Putative flavin-containing monooxygenase/0.470
3pz3PZ3Geranylgeranyl transferase type-2 subunit beta2.5.1.600.470
3r43ID8Aldo-keto reductase family 1 member C3/0.470
4jq1NPSAldo-keto reductase family 1 member C2/0.470
4pnmNU1Tankyrase-22.4.2.300.470
5dsg0HKMuscarinic acetylcholine receptor M4/0.470
1oc1ASVIsopenicillin N synthase1.21.3.10.469
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.469
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase/0.469
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.469
3f3y4OABile salt sulfotransferase2.8.2.140.469
3ocx2AMLipoprotein E/0.469
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.469
4dbw511Aldo-keto reductase family 1 member C3/0.469
4yao2AMNADPH--cytochrome P450 reductase/0.469
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.468
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.468
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.468
3geyP34Poly [ADP-ribose] polymerase 152.4.2.300.468
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.468
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.468
4l341VGTankyrase-22.4.2.300.468
4qtnNNRNicotinamide riboside transporter PnuC/0.468
1dr4HBIDihydrofolate reductase1.5.1.30.467
1yhoTRRDihydrofolate reductase1.5.1.30.467
2fjm073Tyrosine-protein phosphatase non-receptor type 13.1.3.480.467
2pb1NFGGlucan 1,3-beta-glucosidase/0.467
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.467
3p9tTCLRepressor/0.467
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.467
1rzuADPGlycogen synthase 12.4.1.210.466
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.466
3b8xG4MPutative pyridoxamine 5-phosphate-dependent dehydrase/0.466
3rthRTHBeta-secretase 13.4.23.460.466
4bjbP34Tankyrase-22.4.2.300.466
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.466
4l6s1WQPoly [ADP-ribose] polymerase 12.4.2.300.466
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.465
2d06ESTSulfotransferase 1A12.8.2.10.465
2g274LGRenin3.4.23.150.465
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.465
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
3qwhKMP17beta-hydroxysteroid dehydrogenase/0.465
3stdMQ0Scytalone dehydratase4.2.1.940.465
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.465
4h7c10HAldo-keto reductase family 1 member C3/0.465
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.464
2a3bCFFEndochitinase B13.2.1.140.464
2braFAD[F-actin]-methionine sulfoxide oxidase MICAL11.14.130.464
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.464
2jl1NAPTriphenylmethane reductase/0.464
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.464
3qeoLLTDeoxycytidine kinase2.7.1.740.464
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.464
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.464
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.464
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.463
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.463
2a4xBLMMitomycin-binding protein/0.463
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.463
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.463
2q94A04Methionine aminopeptidase/0.463
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.463
3ghwGHWDihydrofolate reductase1.5.1.30.463
3hxdBD7Geranylgeranyl transferase type-2 subunit beta2.5.1.600.463
3m0iZSTAldose reductase1.1.1.210.463
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.463
4kzl20DTankyrase-22.4.2.300.463
4l321VFTankyrase-22.4.2.300.463
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
4m0f1YKAcetylcholinesterase3.1.1.70.463
4nwiCTN7-methylguanosine phosphate-specific 5'-nucleotidase/0.463
1ej3CZHAequorin-2/0.462
1rkwPNTHTH-type transcriptional regulator QacR/0.462
1t13INI6,7-dimethyl-8-ribityllumazine synthase 2/0.462
2aovC2MHistamine N-methyltransferase2.1.1.80.462
2cbqTH2Neocarzinostatin/0.462
2ct8MSPMethionine--tRNA ligase6.1.1.100.462
2pdbZSTAldose reductase1.1.1.210.462
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
3nxtD2EDihydrofolate reductase1.5.1.30.462
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.462
2rh1CAUBeta-2 adrenergic receptor/0.462
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
2b8jADNClass B acid phosphatase3.1.3.20.461
2vi5Y196,7-dimethyl-8-ribityllumazine synthase2.5.1.780.461
2w6cBM4Acetylcholinesterase3.1.1.70.461
2xtbKRMAdenosine kinase, putative/0.461
2y6fM9FIsopenicillin N synthase1.21.3.10.461
3dr7GPDGDP-perosamine synthase/0.461
4l5b1UXDeoxycytidine kinase2.7.1.740.461
4xt8TMQPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc/0.461
1dlrMXADihydrofolate reductase1.5.1.30.460
1s3uTQDDihydrofolate reductase1.5.1.30.460
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.460
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.460
2bd0BIOSepiapterin reductase/0.460
2j3qTFLAcetylcholinesterase3.1.1.70.460
3cotSTR3-oxo-5-beta-steroid 4-dehydrogenase/0.460
3djlFADPutative acyl-CoA dehydrogenase AidB1.3.990.460
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.460
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.460
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.460
4kxjP34Nucleoprotein/0.460
4stdBFSScytalone dehydratase4.2.1.940.460
1bk0ACVIsopenicillin N synthase1.21.3.10.459
1eveE20Acetylcholinesterase3.1.1.70.459
1fmlRTLRetinol dehydratase/0.459
1w76GNTAcetylcholinesterase3.1.1.70.459
2z2w770Wee1-like protein kinase2.7.10.20.459
2zfr46UProthrombin3.4.21.50.459
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
3nx2FERFerulic acid decarboxylase/0.459
3uzxAOM3-oxo-5-beta-steroid 4-dehydrogenase/0.459
4bfuZVUPantothenate kinase2.7.1.330.459
4dbuBT9Aldo-keto reductase family 1 member C3/0.459
5d6lCAUBeta-2 adrenergic receptor/0.459
1jf0CZHObelin/0.458
1s36CEIObelin/0.458
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.458
1yc2NADNAD-dependent protein deacylase 2/0.458
2vrjNCWBeta-glucosidase A3.2.1.210.458
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.458
4bfxZVXPantothenate kinase2.7.1.330.458
4gtt7TQGeranylgeranyl transferase type-2 subunit beta2.5.1.600.458
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.458
4ia05BBcGMP-specific 3',5'-cyclic phosphodiesterase/0.458
4l4v1VYMajor histocompatibility complex class I-related gene protein/0.458
4qa2SHHHistone deacetylase 83.5.1.980.458
4uugPXGBranched-chain amino acid aminotransferase, putative/0.458
1pj6FOLDimethylglycine oxidase1.5.3.100.457
1xi2CB1Ribosyldihydronicotinamide dehydrogenase [quinone]/0.457
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
1xzqFONtRNA modification GTPase MnmE3.6.50.457
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
2obxINI6,7-dimethyl-8-ribityllumazine synthase 22.5.1.780.457
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
2ycnP61Tyrosine phenol-lyase4.1.99.20.457
3iu9T07Methionine aminopeptidase 2/0.457
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
3oadLPORenin3.4.23.150.457
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.457
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.457
4fal0T0Aldo-keto reductase family 1 member C3/0.457
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.457
4xoqF42Coenzyme F420:L-glutamate ligase/0.457
3uonQNBMuscarinic acetylcholine receptor M2/0.457
1afsTES3-alpha-hydroxysteroid dehydrogenase1.1.1.500.456
1q6nP90Tyrosine-protein phosphatase non-receptor type 13.1.3.480.456
1zuaTOLAldo-keto reductase family 1 member B101.1.10.456
2vq7NAPPutative flavin-containing monooxygenase/0.456
2xi4AFTAcetylcholinesterase3.1.1.70.456
3bjcWANcGMP-specific 3',5'-cyclic phosphodiesterase/0.456
3hbfMYCFlavonoid 3-O-glucosyltransferase2.4.10.456
3ocw3AMLipoprotein E/0.456
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
3t0kDCQSulfide-quinone reductase/0.456
3zo7K6HMuconolactone Delta-isomerase/0.456
4bz8J38Histone deacetylase/0.456
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.456
8catNDPCatalase1.11.1.60.456
4mqt2CUMuscarinic acetylcholine receptor M2/0.456
1odcA8BAcetylcholinesterase3.1.1.70.455
1s9dAFBCytohesin-2/0.455
1s9dAFBADP-ribosylation factor 1/0.455
1yw8A75Methionine aminopeptidase 2/0.455
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.455
2gyuHI6Acetylcholinesterase3.1.1.70.455
2vt4P32Beta-1 adrenergic receptor/0.455
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
3irhDTPHD domain protein/0.455
3ogkOGKCoronatine-insensitive protein 1/0.455
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.455
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.455
4a33PS8Glycylpeptide N-tetradecanoyltransferase/0.455
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.455
4ddrMMVDihydrofolate reductase1.5.1.30.455
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.455
1dx6GNTAcetylcholinesterase3.1.1.70.454
1ktsC24Prothrombin3.4.21.50.454
1ut6A8NAcetylcholinesterase3.1.1.70.454
1w4lGL8Acetylcholinesterase3.1.1.70.454
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
2qw8NAPEugenol synthase 11.1.1.3180.454
2v5uFMNFlavodoxin/0.454
3fx4FX4Alcohol dehydrogenase [NADP(+)]1.1.1.20.454
3rmeRMEAcidic mammalian chitinase3.2.1.140.454
4bfyZVYPantothenate kinase2.7.1.330.454
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.454
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.454
4xp1LDPSodium-dependent dopamine transporter/0.454
4yu153NAldose reductase1.1.1.210.454
2ycxP32Beta-1 adrenergic receptor/0.454
1ycgFMNNitric oxide reductase10.453
2mokFMNFlavodoxin 1/0.453
2vqjTFGHistone deacetylase 43.5.1.980.453
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.453
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.453
3rsv3RSBeta-secretase 13.4.23.460.453
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.453
3znqSS8D-amino-acid oxidase1.4.3.30.453
4amjCVDBeta-1 adrenergic receptor/0.453
4dyb0MHNucleoprotein/0.453
4j7hTRHPCZA361.3/0.453
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.453
5dozNDPJamJ/0.453
5ds309LPoly [ADP-ribose] polymerase 12.4.2.300.453
4u163C0Muscarinic acetylcholine receptor M3/0.453
1c7oPPGHemolysin/0.452
1digL37C-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.452
1h42FADFerredoxin--NADP reductase1.18.1.20.452
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.452
2gywOBIAcetylcholinesterase3.1.1.70.452
2v57PRLTetR family transcriptional regulator/0.452
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.452
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.452
3ihgVAKAklavinone 12-hydroxylase RdmE/0.452
4a16H34Acetylcholinesterase3.1.1.70.452
4bj9UHBTankyrase-22.4.2.300.452
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.452
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.452
4kmzFOLFolate receptor beta/0.452
5dp2NAPCurF/0.452
1esmCOAPantothenate kinase2.7.1.330.451
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
1v3q2DIPurine nucleoside phosphorylase2.4.2.10.451
2cekN8TAcetylcholinesterase3.1.1.70.451
2zhw12UProthrombin3.4.21.50.451
3c4hDRLPoly [ADP-ribose] polymerase 32.4.2.300.451
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
3ge7AFQQueuine tRNA-ribosyltransferase2.4.2.290.451
3jq7DX2Pteridine reductase, putative/0.451
3klbFMNUncharacterized protein/0.451
4b2gV1NUncharacterized protein/0.451
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
4f0rMTA5-methylthioadenosine/S-adenosylhomocysteine deaminase/0.451
4l0t1V0Tankyrase-22.4.2.300.451
4n9qFMNFMN-dependent NADH-azoreductase 1/0.451
4qjcIXEDihydrofolate reductase1.5.1.30.451
5a4vQUEGlutathione S-transferase F22.5.1.180.451
5a4wQCTGlutathione S-transferase F22.5.1.180.451
1dgbNDPCatalase1.11.1.60.450
1h60STRPentaerythritol tetranitrate reductase/0.450
1kmvLIIDihydrofolate reductase1.5.1.30.450
1obnASVIsopenicillin N synthase1.21.3.10.450
1odnAPVIsopenicillin N synthase1.21.3.10.450
1qjfACSIsopenicillin N synthase1.21.3.10.450
2dhfDZFDihydrofolate reductase1.5.1.30.450
2ovvPFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
2zdv37UProthrombin3.4.21.50.450
3br3ETHTH-type transcriptional regulator QacR/0.450
3cr0809Wee1-like protein kinase2.7.10.20.450
3jtaH4BNitric oxide synthase, brain1.14.13.390.450
3n19FNRXenobiotic reductase/0.450
3nxrD2DDihydrofolate reductase1.5.1.30.450
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.450
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.450
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.450
1g3mPCQEstrogen sulfotransferase2.8.2.40.449
1gpnHUBAcetylcholinesterase3.1.1.70.449
1lgtBP3Biphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.449
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.449
1pkfEPDEpothilone C/D epoxidase1.140.449
1q5dEPBEpothilone C/D epoxidase1.140.449
1qtiGNTAcetylcholinesterase3.1.1.70.449
1trkTPPTransketolase 12.2.1.10.449
1uhjCZBAequorin-2/0.449
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
1ychFMNNitric oxide reductase10.449
2ckmAA7Acetylcholinesterase3.1.1.70.449
2iu8UD1UDP-3-O-acylglucosamine N-acyltransferase2.3.10.449
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
2w3mFOLDihydrofolate reductase1.5.1.30.449
3fvuIACKynurenine--oxoglutarate transaminase 12.6.1.70.449
3mc5393Aldose reductase1.1.1.210.449
3mjrAC2Deoxycytidine kinase2.7.1.740.449
3qe2FMNNADPH--cytochrome P450 reductase/0.449
3zj6VM2Raucaffricine-O-beta-D-glucosidase3.2.1.1250.449
4j7gTRHPCZA361.3/0.449
5cmx0G6Prothrombin3.4.21.50.449
5dsyUHBPoly [ADP-ribose] polymerase 22.4.2.300.449
5epvACPBlue-light-activated histidine kinase2.7.13.30.449
5kf9ACOPredicted acetyltransferase/0.449
1go2FADFerredoxin--NADP reductase1.18.1.20.448
1gt5BZQOdorant-binding protein/0.448
1k4mNADNicotinate-nucleotide adenylyltransferase2.7.7.180.448
1w19T1P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.448
2cf9348Prothrombin3.4.21.50.448
2gmvUN8Phosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.448
3arvSAUChitinase A/0.448
3b9gIMHIAG-nucleoside hydrolase/0.448
3cmfPDN3-oxo-5-beta-steroid 4-dehydrogenase/0.448
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.448
3nhlYTRRibosyldihydronicotinamide dehydrogenase [quinone]/0.448
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
4f79P53Putative phospho-beta-glucosidase/0.448
4hmn16JAldo-keto reductase family 1 member C3/0.448
4xo7ASDAldo-keto reductase family 1 member C2/0.448
4xp4COCSodium-dependent dopamine transporter/0.448
5agkH4BNitric oxide synthase, brain1.14.13.390.448
1ihiIU5Aldo-keto reductase family 1 member C2/0.447
1qv0CZHObelin/0.447
1t3zCAOFormyl-CoA:oxalate CoA-transferase/0.447
1xmmM7Gm7GpppX diphosphatase3.6.1.590.447
1yunATPProbable nicotinate-nucleotide adenylyltransferase2.7.7.180.447
2q92B23Methionine aminopeptidase/0.447
2uuj896Prothrombin3.4.21.50.447
2xejOKDGlutamate carboxypeptidase 23.4.17.210.447
2xujTZ5Acetylcholinesterase3.1.1.70.447
3jq8DX3Pteridine reductase, putative/0.447
3o73O73Ribosyldihydronicotinamide dehydrogenase [quinone]/0.447
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.447
4ey6GNTAcetylcholinesterase3.1.1.70.447
4g8cC6LAlpha/beta hydrolase fold protein/0.447
4r5wXAVPoly [ADP-ribose] polymerase 12.4.2.300.447
1drfFOLDihydrofolate reductase1.5.1.30.446
1e66HUXAcetylcholinesterase3.1.1.70.446
1rkpIBMcGMP-specific 3',5'-cyclic phosphodiesterase/0.446
1w6rGNTAcetylcholinesterase3.1.1.70.446
1xngDNDNH(3)-dependent NAD(+) synthetase6.3.1.50.446
2rd678PPoly [ADP-ribose] polymerase 12.4.2.300.446
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.446
2wzySQXSoluble acetylcholine receptor/0.446
2y0jAXCcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
3ce0P34Poly [ADP-ribose] polymerase 32.4.2.300.446
3clxX22E3 ubiquitin-protein ligase XIAP6.3.20.446
3iu7FCDMethionine aminopeptidase 2/0.446
3ugrIMNAldo-keto reductase family 1 member C3/0.446
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.446
4hlf15ZTankyrase-22.4.2.300.446
4jtqFLPAldo-keto reductase family 1 member C2/0.446
4lsaBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.446
4tjy3GNTankyrase-22.4.2.300.446
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.446
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
1mvsDTMDihydrofolate reductase1.5.1.30.445
1qvtPRLHTH-type transcriptional regulator QacR/0.445
1x8lOXRRetinol dehydratase/0.445
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
1z71L17Prothrombin3.4.21.50.445
2r2mI50Prothrombin3.4.21.50.445
2xluNA7Putative flavin-containing monooxygenase/0.445
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.445
3occDIHPurine nucleoside phosphorylase DeoD-type/0.445
3pqbVGPPutative oxidoreductase/0.445
3q7fED2Uncharacterized protein/0.445
3t31DCQSulfide-quinone reductase/0.445
3uweVJJAldo-keto reductase family 1 member C3/0.445
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
3zmg6Z0Beta-secretase 13.4.23.460.445
4d6qPD2Lysine-specific demethylase 4D1.14.110.445
4gvsF4MMethenyltetrahydromethanopterin cyclohydrolase3.5.4.270.445
4hkkAGITankyrase-22.4.2.300.445
4hlm16STankyrase-22.4.2.300.445
4jq2SUZAldo-keto reductase family 1 member C2/0.445
1azlFMNFlavodoxin/0.444
1kmyBPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.444
1sl9CZHObelin/0.444
1tllFMNNitric oxide synthase, brain1.14.13.390.444
1w87FADFerredoxin--NADP reductase1.18.1.20.444
2ohhFMNType A flavoprotein FprA10.444
2pucGUNHTH-type transcriptional repressor PurR/0.444
2wm3NFLNmrA-like family domain-containing protein 1/0.444
3eufBAUUridine phosphorylase 1/0.444
3h3r14HCollagen type IV alpha-3-binding protein/0.444
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.444
3uzzASD3-oxo-5-beta-steroid 4-dehydrogenase/0.444
3v94WYQPhosphodiesterase/0.444
3zkyWT4Isopenicillin N synthase1.21.3.10.444
4li61XOTankyrase-12.4.2.300.444
4zzjCNANAD-dependent protein deacetylase sirtuin-13.5.10.444
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.444
1dpmEBPParathion hydrolase3.1.8.10.443
1hb3SCVIsopenicillin N synthase1.21.3.10.443
1nbhSAMGlycine N-methyltransferase2.1.1.200.443
1pd9CO4Dihydrofolate reductase1.5.1.30.443
1uk1FRQPoly [ADP-ribose] polymerase 12.4.2.300.443
1xidASCXylose isomerase5.3.1.50.443
2aouCQAHistamine N-methyltransferase2.1.1.80.443
2cmfF11Acetylcholinesterase3.1.1.70.443
2fzjDH3Dihydrofolate reductase1.5.1.30.443
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
2qx7NAPEugenol synthase 11.1.1.3180.443
2vbpVB1Isopenicillin N synthase1.21.3.10.443
2vqzMGTPolymerase basic protein 2/0.443
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
2zsbADPPantothenate kinase2.7.1.330.443
3hiiPNTAmiloride-sensitive amine oxidase [copper-containing]/0.443
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.443
3mauEXTPutative sphingosine-1-phosphate lyase/0.443
3n0hTOPDihydrofolate reductase1.5.1.30.443
3nhpHGZRibosyldihydronicotinamide dehydrogenase [quinone]/0.443
4cb741GPolymerase basic protein 2/0.443
4hlh20DTankyrase-22.4.2.300.443
4iksTFDMethionine aminopeptidase 1/0.443
4jq3ZOMAldo-keto reductase family 1 member C2/0.443
4jqaID8Aldo-keto reductase family 1 member C2/0.443
4tnzTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.443
5fljQUEQuercetinase QueD/0.443
1lnmDTXBilin-binding protein/0.442
1q84TZ4Acetylcholinesterase3.1.1.70.442
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.442
1sqi8694-hydroxyphenylpyruvate dioxygenase/0.442
2c9dPHR6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
2e94364Geranylgeranyl pyrophosphate synthase/0.442
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.442
2gl0ADNUncharacterized protein/0.442
2jgsBTNAvidin/0.442
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.442
2xegCI9Glutamate carboxypeptidase 23.4.17.210.442
2zi63D1Deoxycytidine kinase2.7.1.740.442
3casASD3-oxo-5-beta-steroid 4-dehydrogenase/0.442
3d27W29Methionine aminopeptidase/0.442
3iu8T03Methionine aminopeptidase 2/0.442
3pce3HPProtocatechuate 3,4-dioxygenase alpha chain1.13.11.30.442
3pce3HPProtocatechuate 3,4-dioxygenase beta chain1.13.11.30.442
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.442
4c1eMCOBeta-lactamase class B VIM-2/0.442
4da50H7Choline kinase alpha2.7.1.320.442
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.442
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
4p9dTMPDeoxycytidylate deaminase/0.442
1e2lTMCThymidine kinase/0.441
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.441
1g63FMNEpidermin decarboxylase4.1.10.441
1pqc444Oxysterols receptor LXR-beta/0.441
1swgBTNStreptavidin/0.441
1ta6177Prothrombin3.4.21.50.441
1umcTDP2-oxoisovalerate dehydrogenase subunit alpha1.2.4.40.441
1umcTDP2-oxoisovalerate dehydrogenase subunit beta1.2.4.40.441
2f59INI6,7-dimethyl-8-ribityllumazine synthase 1/0.441
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.441
3k7mFAD6-hydroxy-L-nicotine oxidase/0.441
3l3lL3LPoly [ADP-ribose] polymerase 12.4.2.300.441
3vilSA0Beta-glucosidase/0.441
3znrNU9Histone deacetylase 73.5.1.980.441
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.441
4b65NDPL-ornithine N(5)-monooxygenase/0.441
4bqwQNMEgl nine homolog 1/0.441
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.441
4jtrIZPAldo-keto reductase family 1 member C2/0.441
4jvnYUGEstrogen sulfotransferase2.8.2.40.441
4mr72BVGamma-aminobutyric acid type B receptor subunit 1/0.441
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.440
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.440
1rpwDIDHTH-type transcriptional regulator QacR/0.440
1u1d181Uridine phosphorylase2.4.2.30.440
1u65CP0Acetylcholinesterase3.1.1.70.440
2bvs2CEProthrombin3.4.21.50.440
2cn0F25Prothrombin3.4.21.50.440
2iejS48Protein farnesyltransferase subunit beta2.5.1.580.440
2in6839Wee1-like protein kinase2.7.10.20.440
2io6330Wee1-like protein kinase2.7.10.20.440
2iviACWIsopenicillin N synthase1.21.3.10.440
2jb4A14Isopenicillin N synthase1.21.3.10.440
2pdiZSTAldose reductase1.1.1.210.440
2pl0STITyrosine-protein kinase Lck2.7.10.20.440
2po3T4K4-dehydrase/0.440
2xugTZ4Acetylcholinesterase3.1.1.70.440
2y60M8FIsopenicillin N synthase1.21.3.10.440
2zgb21UProthrombin3.4.21.50.440
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.440
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.440
3gf4U5PUDP-galactopyranose mutase5.4.99.90.440
3gi2GHWDihydrofolate reductase1.5.1.30.440
3k47D09Dihydrofolate reductase1.5.1.30.440
3nn6HNK6-hydroxy-L-nicotine oxidase/0.440
3nytULPUDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.440
3sfxJANUncharacterized protein/0.440
4a86H35Major pollen allergen Bet v 1-A/0.440
4bprFADFerredoxin--NADP reductase1.18.1.20.440
4g090VDHistidinol dehydrogenase/0.440
5dc5B3NHistone deacetylase 83.5.1.980.440
2y0468HBeta-1 adrenergic receptor/0.440
5d5aCAUBeta-2 adrenergic receptor/0.440