sc-PDB

List of CHEMBLId :

This value allows a number of roughly comparable measures of half-maximal response concentration/potency/affinity to be compared on a negative logarithmic scale (e.g., an IC50 measurement of 1nM would have a pChEMBL value of 9).

Uniprot Annotation

Name:	cGMP-specific 3',5'-cyclic phosphodiesterase
ID:	PDE5A_HUMAN
AC:	O76074
Organism:	Homo sapiens
Reign:	Eukaryota
TaxID:	9606
EC Number:	/

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Chains:

Chain Name:	Percentage of Residues within binding site
A	100 %

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Ligand binding site composition:

B-Factor:	27.686
Number of residues:	20
Including
Standard Amino Acids:	20
Non Standard Amino Acids:	0
Water Molecules:	0
Cofactors:
Metals:

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Cavity properties

Ligandability	Volume (Å3)
0.762	641.250

% Hydrophobic	% Polar
51.05	48.95
According to VolSite

HET Code:	IBM
Formula:	C10H14N4O2
Molecular weight:	222.244 g/mol
DrugBank ID:	DB07954
Buried Surface Area:	62.37 %
Polar Surface area:	69.3 Å2

Number of
H-Bond Acceptors:	3
H-Bond Donors:	1
Rings:	2
Aromatic rings:	1
Anionic atoms:	0
Cationic atoms:	0
Rule of Five Violation:	0
Rotatable Bonds:	2

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Mass center Coordinates

X	Y	Z
43.7659	15.5538	48.4273

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