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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3rqqBA3ADP-dependent (S)-NAD(P)H-hydrate dehydratase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3rqqBA3ADP-dependent (S)-NAD(P)H-hydrate dehydratase/1.000
3rq6APRADP-dependent (S)-NAD(P)H-hydrate dehydratase/0.650
3rqhB6PADP-dependent (S)-NAD(P)H-hydrate dehydratase/0.615
3rq8AP5ADP-dependent (S)-NAD(P)H-hydrate dehydratase/0.595
2ejvNADL-threonine 3-dehydrogenase/0.512
1i5cADPChemotaxis protein CheA2.7.13.30.507
3ohh3HHBeta-secretase 13.4.23.460.507
2iko7IGRenin3.4.23.150.500
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.498
4bfvZVVPantothenate kinase2.7.1.330.497
1fxsNAPGDP-L-fucose synthase/0.496
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.494
3hyg099A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.493
3kgcLY7Glutamate receptor 2/0.493
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.493
4hh4SAHCcbJ/0.492
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.490
1ay0TPPTransketolase 12.2.1.10.489
1f8fNADBenzyl alcohol dehydrogenase/0.489
1tqf32PBeta-secretase 13.4.23.460.489
3lqfNADGalactitol dehydrogenase/0.489
1tehNADAlcohol dehydrogenase class-31.1.1.10.488
4k6fNAPPutative Acetoacetyl-CoA reductase/0.488
5dp2NAPCurF/0.488
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.487
3ieuGDPGTPase Era/0.487
3p3zP3ZPutative cytochrome P450/0.487
2gesCOKPantothenate kinase2.7.1.330.486
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.485
3oqfS51Renin3.4.23.150.485
4jnkNAIL-lactate dehydrogenase A chain1.1.1.270.485
1cf3FADGlucose oxidase1.1.3.40.484
2gtnLIEMitogen-activated protein kinase 14/0.484
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.484
1lbcCYZGlutamate receptor 2/0.483
2xx91NFGlutamate receptor 2/0.483
3in6FMNUncharacterized protein/0.483
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.482
3jv7NADSecondary alcohol dehydrogenase/0.482
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.482
4bftZVTPantothenate kinase2.7.1.330.482
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.481
1in5ADPHolliday junction ATP-dependent DNA helicase RuvB/0.481
2vnjFADNADPH:ferredoxin reductase/0.481
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.481
3rpeFADPutative modulator of drug activity/0.481
1xddAAYIntegrin alpha-L/0.480
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.480
1bsvNDPGDP-L-fucose synthase/0.479
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.479
1drhNAPDihydrofolate reductase1.5.1.30.478
2a94AP0L-lactate dehydrogenase1.1.1.270.478
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.478
4rvgTYDD-mycarose 3-C-methyltransferase/0.478
1dr3TAPDihydrofolate reductase1.5.1.30.476
1udaUFGUDP-glucose 4-epimerase5.1.3.20.476
2iviACWIsopenicillin N synthase1.21.3.10.476
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.476
4bcaFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.476
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.476
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.476
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.476
3qlrNDPDihydrofolate reductase1.5.1.30.475
3gvhNADMalate dehydrogenase/0.474
3oqkS52Renin3.4.23.150.474
1fmlRTLRetinol dehydratase/0.473
1ma0NADAlcohol dehydrogenase class-31.1.1.10.473
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.473
2ahrNAPPyrroline-5-carboxylate reductase/0.473
2x06NADL-sulfolactate dehydrogenase/0.473
3oibFDAPutative acyl-CoA dehydrogenase/0.473
3wleNAD(R)-specific carbonyl reductase/0.473
3sn6P0GBeta-2 adrenergic receptor/0.473
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.472
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.472
3wagTYDGlycosyltransferase/0.472
3zbrNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.472
2c27ACOMycothiol acetyltransferase2.3.1.1890.471
2vkeTACTetracycline repressor protein class D/0.471
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.471
3cltFADElectron transfer flavoprotein subunit alpha/0.471
3qt62P0Mevalonate diphosphate decarboxylase/0.471
5adhAPRAlcohol dehydrogenase E chain1.1.1.10.471
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.471
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.470
2jb4A14Isopenicillin N synthase1.21.3.10.470
2xpuTDCTetracycline repressor protein class D/0.470
4rvfTYDD-mycarose 3-C-methyltransferase/0.470
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.470
1e3eNAIAlcohol dehydrogenase 41.1.1.10.469
1tj0FADBifunctional protein PutA1.5.5.20.469
1ykfNAPNADP-dependent isopropanol dehydrogenase1.1.1.800.469
2qtcTDKPyruvate dehydrogenase E1 component1.2.4.10.469
2vnkFADNADPH:ferredoxin reductase/0.469
3c1y2BADNA integrity scanning protein DisA/0.469
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.469
3kruFMNNADH:flavin oxidoreductase/NADH oxidase/0.469
3s1dZIRCytokinin dehydrogenase 11.5.99.120.469
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.469
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.469
4jb1FADUDP-N-acetylenolpyruvoylglucosamine reductase/0.469
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.468
2a1hGBNBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.468
2fzwNADAlcohol dehydrogenase class-31.1.1.10.468
3fwjCAMCamphor 5-monooxygenase1.14.15.10.468
4bfzZVZPantothenate kinase2.7.1.330.468
1ia1NDPDihydrofolate reductase1.5.1.30.467
1qorNDPQuinone oxidoreductase 1/0.467
2g1n1IGRenin3.4.23.150.467
2vkvTDCTetracycline repressor protein class D/0.467
2w6qOA5Biotin carboxylase6.3.4.140.467
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.467
3own3OWRenin3.4.23.150.467
3q43D66M1 family aminopeptidase3.4.110.467
4r81FMNPredicted NADH dehydrogenase/0.467
2pg0FADAcyl-CoA dehydrogenase/0.466
3o0o5ADVitamin B12-dependent ribonucleotide reductase/0.466
4b4dFADFerredoxin-NADP reductase/0.466
4dplNAPMalonyl-CoA reductase1.2.1.750.466
4uymVOR14-alpha sterol demethylase Cyp51B/0.466
5d3qGDPDynamin-13.6.5.50.466
5irnADPNucleotide binding oligomerization domain containing 2/0.466
1a8rGTPGTP cyclohydrolase 13.5.4.160.465
1bk0ACVIsopenicillin N synthase1.21.3.10.465
1i59ADPChemotaxis protein CheA2.7.13.30.465
1xs7MMIBeta-secretase 13.4.23.460.465
2xhd7T9Glutamate receptor 2/0.465
3phiNDPShikimate dehydrogenase (NADP(+))/0.465
4bb3KKAIsopenicillin N synthase1.21.3.10.465
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.465
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.465
4gl4NAIAlcohol dehydrogenase class-3/0.465
1i59ANPChemotaxis protein CheA2.7.13.30.464
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.464
1vyrFMNPentaerythritol tetranitrate reductase/0.464
2fznFADBifunctional protein PutA1.5.5.20.464
2ifaFMNUncharacterized protein/0.464
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.464
3clrFADElectron transfer flavoprotein subunit alpha/0.464
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.464
3hk1B64Fatty acid-binding protein, adipocyte/0.464
3p62FMNPentaerythritol tetranitrate reductase/0.464
3uk6ADPRuvB-like 23.6.4.120.464
3uoyFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.464
3zhsTD6Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.464
4bfsZVSPantothenate kinase2.7.1.330.464
4gyy12VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.464
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.464
1a8pFADFerredoxin--NADP reductase/0.463
1cdoNADAlcohol dehydrogenase 11.1.1.10.463
1dxyNADD-2-hydroxyisocaproate dehydrogenase1.1.10.463
1l8aTDPPyruvate dehydrogenase E1 component1.2.4.10.463
2ikuLIYRenin3.4.23.150.463
3clsFADElectron transfer flavoprotein subunit alpha/0.463
3djjFADGlutathione reductase, mitochondrial1.8.1.70.463
3fp0FP015-O-acetyltransferase/0.463
3gw9VNILanosterol 14-alpha-demethylase/0.463
3to6LYS_CMCHistone acetyltransferase ESA1/0.463
3vmmP0DAlanine--anticapsin ligase/0.463
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.463
4fxy0W2Neurolysin, mitochondrial3.4.24.160.463
1g63FMNEpidermin decarboxylase4.1.10.462
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.462
1nhhANPDNA mismatch repair protein MutL/0.462
1t2cNAIL-lactate dehydrogenase1.1.1.270.462
1vbiNADMalate/L-lactate dehydrogenase family protein/0.462
1xe55FEPlasmepsin-23.4.23.390.462
2g247IGRenin3.4.23.150.462
2qbuSAHPrecorrin-2 methyltransferase/0.462
2qimZEAClass 10 plant pathogenesis-related protein/0.462
2xaaNADSecondary alcohol dehydrogenase/0.462
2xvw9NRSerum albumin/0.462
3hyoADPPyridoxal kinase/0.462
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
3q9bB3NAcetylpolyamine amidohydrolase/0.462
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.462
4kbyC2EStimulator of interferon genes protein/0.462
4m83ERYOleandomycin glycosyltransferase2.4.10.462
4ocpADPN-acetylhexosamine 1-kinase2.7.1.1620.462
1g1aNADdTDP-glucose 4,6-dehydratase/0.461
1lluNADAlcohol dehydrogenase/0.461
1o76CAMCamphor 5-monooxygenase1.14.15.10.461
3d91REMRenin3.4.23.150.461
3ljtLA3A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.461
3nxxNDPDihydrofolate reductase1.5.1.30.461
4oztP1AEcdysone receptor, putative/0.461
1mczRMNBenzoylformate decarboxylase4.1.1.70.460
1tilATPAnti-sigma F factor/0.460
1yrdCAMCamphor 5-monooxygenase1.14.15.10.460
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.460
2xvv9DNSerum albumin/0.460
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.460
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.460
4ryvZEAProtein LlR18A/0.460
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.460
1galFADGlucose oxidase1.1.3.40.459
1vzaUMPThymidylate synthase/0.459
1w6hTITPlasmepsin-23.4.23.390.459
2ed3SAHDiphthine synthase/0.459
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.459
2zb3NDPProstaglandin reductase 21.3.1.480.459
3eksCY9Actin-5C/0.459
3gwfFADCyclohexanone monooxygenase/0.459
3zcsCAWGlycogen phosphorylase, muscle form2.4.1.10.459
4bv9NDPKetimine reductase mu-crystallin1.5.1.250.459
4lcjNADC-terminal-binding protein 2/0.459
4yaoFMNNADPH--cytochrome P450 reductase/0.459
5fl3ADPPili retraction protein PilT/0.459
5jlaNADPutative short-chain dehydrogenase/reductase/0.459
1h51FMNPentaerythritol tetranitrate reductase/0.458
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.458
1nytNAPShikimate dehydrogenase (NADP(+))/0.458
1rp7TZDPyruvate dehydrogenase E1 component1.2.4.10.458
2ejzSAHDiphthine synthase/0.458
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.458
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.458
2is0I03Beta-secretase 13.4.23.460.458
2vwqNAPGlucose 1-dehydrogenase/0.458
2y0mACOHistone acetyltransferase KAT8/0.458
3cluFADElectron transfer flavoprotein subunit alpha/0.458
3fktSIIBeta-secretase 13.4.23.460.458
3il1B5DGlutamate receptor 2/0.458
3jziJZLBiotin carboxylase6.3.4.140.458
3mt817TGlycogen phosphorylase, muscle form2.4.1.10.458
3w32W32Epidermal growth factor receptor2.7.10.10.458
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.458
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.458
4ipw1G7Mycocyclosin synthase1.14.21.90.458
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.458
1cjkFOKAdenylate cyclase type 2/0.457
1cjkFOKAdenylate cyclase type 5/0.457
1fmjRTLRetinol dehydratase/0.457
1gc5ADPADP-dependent glucokinase2.7.1.1470.457
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.457
1h74ADPHomoserine kinase2.7.1.390.457
1rneC60Renin3.4.23.150.457
1t88CAMCamphor 5-monooxygenase1.14.15.10.457
1tsxUMPThymidylate synthase/0.457
1x1cSAHC-20 methyltransferase/0.457
1yqzCOACoenzyme A disulfide reductase/0.457
2c29NAPDihydroflavonol 4-reductase/0.457
2gjlFMNNitronate monooxygenase1.13.12.160.457
2jlcTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.457
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.457
2qtaTDPPyruvate dehydrogenase E1 component1.2.4.10.457
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.457
3dm6757Beta-secretase 13.4.23.460.457
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
3ik6HCZGlutamate receptor 2/0.457
3pfdFDAAcyl-CoA dehydrogenase FadE25/0.457
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
4nbwNADShort-chain dehydrogenase/reductase SDR/0.457
1h50FMNPentaerythritol tetranitrate reductase/0.456
1jioDEB6-deoxyerythronolide B hydroxylase/0.456
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.456
2dcnADP2-keto-3-deoxy-gluconate kinase/0.456
2vprTDCTetracycline repressor protein class H/0.456
2w3bNDPDihydrofolate reductase1.5.1.30.456
2xw7NDPDihydrofolate reductase/0.456
3cgeCOACoenzyme A disulfide reductase/0.456
3ibqATPPyridoxal kinase/0.456
3lq4TDPPyruvate dehydrogenase E1 component1.2.4.10.456
4djaFAD(6-4) photolyase/0.456
4dpwAGSMevalonate diphosphate decarboxylase/0.456
4ejmNAPPutative zinc-binding dehydrogenase/0.456
4g3jVNTLanosterol 14-alpha-demethylase/0.456
4k8s1QTBeta-secretase 13.4.23.460.456
4u0mGTPCyclic GMP-AMP synthase/0.456
6ctsCICCitrate synthase, mitochondrial2.3.3.10.456
1gjvAGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial2.7.11.40.455
1i5aACPChemotaxis protein CheA2.7.13.30.455
1mjaCOAHistone acetyltransferase ESA1/0.455
1omoNADAlanine dehydrogenase/0.455
2vnaNAPProstaglandin reductase 21.3.1.480.455
3fql79ZGenome polyprotein2.7.7.480.455
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.455
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.455
3koyZ97D-ornithine 4,5-aminomutase subunit beta/0.455
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.455
3uylTYDProbable NDP-rhamnosyltransferase/0.455
4ambDUDPutative glycosyl transferase/0.455
4i1iNADMalate dehydrogenase/0.455
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.454
1orrNADCDP-paratose 2-epimerase/0.454
2bifANP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 42.7.1.1050.454
2hm1LIQBeta-secretase 13.4.23.460.454
3b4yF42F420-dependent glucose-6-phosphate dehydrogenase/0.454
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.454
3ruaNADUDP-N-acetylglucosamine 4-epimerase/0.454
3tjzGNPADP-ribosylation factor 1/0.454
3zoiM2WIsopenicillin N synthase1.21.3.10.454
4bfxZVXPantothenate kinase2.7.1.330.454
4egbNADdTDP-glucose 4,6-dehydratase/0.454
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.454
4ocvANPAminoglycoside phosphotransferase/0.454
5a3cNADSIR2 family protein/0.454
5dw60T1Succinyl-CoA:acetate CoA-transferase/0.454
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.453
1d4dFADFumarate reductase flavoprotein subunit1.3.5.40.453
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.453
2abbFMNPentaerythritol tetranitrate reductase/0.453
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.453
2x7hPFNProstaglandin reductase 310.453
2yyuC5POrotidine 5'-phosphate decarboxylase/0.453
3bbrBHYGlutamate receptor 2/0.453
3cgdCOACoenzyme A disulfide reductase/0.453
3etgNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.453
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.453
3iaeD7KBenzaldehyde lyase/0.453
3oetNADErythronate-4-phosphate dehydrogenase/0.453
3r83Z14Cyclin-dependent kinase 22.7.11.220.453
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.453
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.453
4fm80UQBeta-secretase 13.4.23.460.453
4gddNAIUDP-galactopyranose mutase/0.453
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.453
4l0qNADAlcohol dehydrogenase class-3/0.453
5bsgNAPPyrroline-5-carboxylate reductase/0.453
5fm7ADPRuvB-like helicase/0.453
1hb3SCVIsopenicillin N synthase1.21.3.10.452
1nzdUPGDNA beta-glucosyltransferase/0.452
2c31TZDOxalyl-CoA decarboxylase4.1.1.80.452
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.452
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.452
2rl1UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.452
2trtTACTetracycline repressor protein class D/0.452
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.452
3ae4FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.452
3b2sB2STrichothecene 3-O-acetyltransferase/0.452
3coy53HPantothenate synthetase6.3.2.10.452
3d84NDPDihydrofolate reductase1.5.1.30.452
3kb1ADPIron-sulfur cluster carrier protein/0.452
4an4DUDPutative glycosyl transferase/0.452
4nxuADPMitochondrial dynamics protein MID51/0.452
1cjtFOKAdenylate cyclase type 2/0.451
1cjtFOKAdenylate cyclase type 5/0.451
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1lf2R37Plasmepsin-23.4.23.390.451
1t85CAMCamphor 5-monooxygenase1.14.15.10.451
1u3dFADCryptochrome-1/0.451
2a0xDIHPurine nucleoside phosphorylase2.4.2.10.451
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.451
2po7CHDFerrochelatase, mitochondrial4.99.1.10.451
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.451
3a3gDLZLumazine protein/0.451
3c212BADNA integrity scanning protein DisA/0.451
3cppCAMCamphor 5-monooxygenase1.14.15.10.451
3f03FMNPentaerythritol tetranitrate reductase/0.451
3hatGLY_VAL_ARG_RNGProthrombin3.4.21.50.451
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.451
3l0lHC3Nuclear receptor ROR-gamma/0.451
3mjhGTPRas-related protein Rab-5A/0.451
3nl6TPSUncharacterized protein/0.451
3otfCMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4/0.451
4m6jNDPDihydrofolate reductase1.5.1.30.451
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.451
1g6kNADGlucose 1-dehydrogenase1.1.1.470.450
1gqtACPRibokinase/0.450
1h63FMNPentaerythritol tetranitrate reductase/0.450
1jq5NADGlycerol dehydrogenase1.1.1.60.450
1mj9COAHistone acetyltransferase ESA1/0.450
1r2jFADFkbI/0.450
1rdwLARActin, alpha skeletal muscle/0.450
1yb5NAPQuinone oxidoreductase1.6.5.50.450
2q1tNADPutative nucleotide sugar epimerase/ dehydratase/0.450
2q7vFADThioredoxin reductase/0.450
2qzlIXSBeta-secretase 13.4.23.460.450
2rcyNAPPyrroline-5-carboxylate reductase/0.450
2vcmM11Isopenicillin N synthase1.21.3.10.450
2vtbFADCryptochrome DASH, chloroplastic/mitochondrial/0.450
2xviFADPutative flavin-containing monooxygenase/0.450
3b70NAPEnoyl reductase LovC10.450
3cgbCOACoenzyme A disulfide reductase/0.450
3d7kD7KBenzaldehyde lyase/0.450
3ge1ADPGlycerol kinase/0.450
3gegNADShort-chain dehydrogenase/reductase SDR/0.450
4bbyFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.450
4eji0QACytochrome P450 2A131.14.14.10.450
4g74FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.450
4iqqUMPThymidylate synthase/0.450
4jq3NAPAldo-keto reductase family 1 member C2/0.450
4m4922YL-lactate dehydrogenase A chain1.1.1.270.450
4m5pFMNNADPH dehydrogenase/0.450
1culFOKAdenylate cyclase type 2/0.449
1culFOKAdenylate cyclase type 5/0.449
1fy7COAHistone acetyltransferase ESA1/0.449
1s20NAD2,3-diketo-L-gulonate reductase1.1.1.1300.449
1xe65FPPlasmepsin-23.4.23.390.449
1zz2B11Mitogen-activated protein kinase 14/0.449
2bunFADAppA protein/0.449
2givACOHistone acetyltransferase KAT8/0.449
2i4qUA4Renin3.4.23.150.449
2v58LZJBiotin carboxylase6.3.4.140.449
2vijC44Beta-secretase 13.4.23.460.449
2xpwOTCTetracycline repressor protein class D/0.449
2znpK55Peroxisome proliferator-activated receptor delta/0.449
3a6qFMNFMN-binding protein/0.449
3cgcCOACoenzyme A disulfide reductase/0.449
3fhxPLPPyridoxal kinase2.7.1.350.449
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.449
3wfjNAD2-dehydropantoate 2-reductase/0.449
3zkyWT4Isopenicillin N synthase1.21.3.10.449
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.449
4du6GTPGTP cyclohydrolase 1/0.449
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.449
4tuvCPZCytochrome P450 1191.140.449
4yryFADGlutamate synthase, beta subunit/0.449
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1kqcFMNOxygen-insensitive NAD(P)H nitroreductase/0.448
1rx1NAPDihydrofolate reductase1.5.1.30.448
2bn4FMNNADPH--cytochrome P450 reductase/0.448
2ed4NAD4-hydroxyphenylacetate 3-monooxygenase reductase component1.5.1.360.448
2ftoCB3Thymidylate synthase/0.448
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.448
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.448
2r0cFADPutative FAD-monooxygenase/0.448
2r9w23CBeta-lactamase3.5.2.60.448
2w9hTOPDihydrofolate reductase1.5.1.30.448
2zhe13UProthrombin3.4.21.50.448
3nr4PYVAbscisic acid receptor PYL2/0.448
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.448
4dc0NDPPutative ketoacyl reductase1.3.10.448
4dt9GMPAPH(2'')-Id/0.448
4eywL0RCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.448
4gid0GHBeta-secretase 13.4.23.460.448
4jalSAHtRNA (cytidine(34)-2'-O)-methyltransferase/0.448
4lsmNADGlyceraldehyde-3-phosphate dehydrogenase/0.448
4uugPXGBranched-chain amino acid aminotransferase, putative/0.448
4xj43ATCyclic GMP-AMP synthase/0.448
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1lf3EH5Plasmepsin-23.4.23.390.447
1njaDCMThymidylate synthase/0.447
1rfgGMPPurine nucleoside phosphorylase2.4.2.10.447
1t87CAMCamphor 5-monooxygenase1.14.15.10.447
1u0hFOKAdenylate cyclase type 2/0.447
1u0hFOKAdenylate cyclase type 5/0.447
2he5NDPAldo-keto reductase family 1 member C211.1.10.447
2irzI02Beta-secretase 13.4.23.460.447
2p83MR0Beta-secretase 13.4.23.460.447
2pckSAHDiphthine synthase/0.447
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.447
3qlsNDPDihydrofolate reductase1.5.1.30.447
4dieC5PCytidylate kinase/0.447
4g7gVFVLanosterol 14-alpha-demethylase/0.447
4i6gFADCryptochrome-2/0.447
4l9kEHFSerum albumin/0.447
4rlsNAIL-lactate dehydrogenase A chain1.1.1.270.447
4xfjANPArgininosuccinate synthase/0.447
6cp4CAMCamphor 5-monooxygenase1.14.15.10.447
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.446
1mp0NADAlcohol dehydrogenase class-31.1.1.10.446
1tj2FADBifunctional protein PutA1.5.5.20.446
2a0yDIHPurine nucleoside phosphorylase2.4.2.10.446
2a5kAZPReplicase polyprotein 1ab3.4.220.446
2dv5SAHDiphthine synthase/0.446
2ebaFADPutative glutaryl-CoA dehydrogenase/0.446
2emuSAHDiphthine synthase/0.446
2h3wCOACarnitine O-acetyltransferase2.3.1.70.446
2hckQUETyrosine-protein kinase HCK2.7.10.20.446
2omeNADC-terminal-binding protein 2/0.446
2qboCAMCamphor 5-monooxygenase1.14.15.10.446
2v5aLZLBiotin carboxylase6.3.4.140.446
3cinNADMyo-inositol-1-phosphate synthase-related protein/0.446
3d2rADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.446
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.90.446
3muoZPRProlyl endopeptidase/0.446
3nbvANPKetohexokinase/0.446
3r9uFADThioredoxin reductase/0.446
3rvhHQ2Lysine-specific demethylase 4A1.14.110.446
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.446
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.446
4d89BXDBeta-secretase 13.4.23.460.446
4djy0KRBeta-secretase 13.4.23.460.446
4i02CMPcAMP-activated global transcriptional regulator CRP/0.446
4kkyCAMCamphor 5-monooxygenase1.14.15.10.446
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.446
4n3cUD1UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.446
4z5wILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.446
1mjbACOHistone acetyltransferase ESA1/0.445
1x8lOXRRetinol dehydratase/0.445
1ybmNAPUncharacterized protein At5g02240/0.445
1z7yAA5Cysteine synthase 12.5.1.470.445
2gblATPCircadian clock protein kinase KaiC2.7.11.10.445
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.445
2xveFADPutative flavin-containing monooxygenase/0.445
3bg7FADPyranose 2-oxidase/0.445
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3etdNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.445
3f3sNADLambda-crystallin homolog/0.445
3h06VBPGlutamate receptor 2/0.445
3h3t16HCollagen type IV alpha-3-binding protein/0.445
3ivgFG5Pantothenate synthetase6.3.2.10.445
3nl6ACPUncharacterized protein/0.445
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.445
3q8xUD1Toxin zeta/0.445
3wycNAPMeso-diaminopimelate D-dehydrogenase1.4.1.160.445
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.445
4k28NADShikimate dehydrogenase family protein/0.445
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.445
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.445
4zs2FLUAlpha-ketoglutarate-dependent dioxygenase FTO/0.445
5ej7TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.445
1cg4IMOAdenylosuccinate synthetase/0.444
1dr2TAPDihydrofolate reductase1.5.1.30.444
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.444
1eupASD6-deoxyerythronolide B hydroxylase/0.444
1hzjUD1UDP-glucose 4-epimerase/0.444
1oonFMNOxygen-insensitive NAD(P)H nitroreductase/0.444
1phgMYTCamphor 5-monooxygenase1.14.15.10.444
1qlhNADAlcohol dehydrogenase E chain1.1.1.10.444
1qo8FADFumarate reductase flavoprotein subunit/0.444
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.444
1zemNADXylitol dehydrogenase/0.444
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
2bgiFADNADPH:ferredoxin reductase/0.444
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.444
2il2LIXRenin3.4.23.150.444
2qw034Z4-chlorobenzoyl CoA ligase/0.444
2v13C40Renin3.4.23.150.444
2wo7ASVIsopenicillin N synthase1.21.3.10.444
2y60M8FIsopenicillin N synthase1.21.3.10.444
2yeiXQIHeat shock protein HSP 90-alpha/0.444
2zsaADPPantothenate kinase2.7.1.330.444
3f1kNAPUncharacterized oxidoreductase YciK10.444
3gobHXXDdmC/0.444
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3mk6ACOPantothenate kinase 32.7.1.330.444
3p74FMNPentaerythritol tetranitrate reductase/0.444
3wbfNAPMeso-diaminopimelate D-dehydrogenase/0.444
3zhvTDWMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.444
4e5yNDPGDP-L-fucose synthase1.1.1.2710.444
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.444
4g3rCAMCamphor 5-monooxygenase1.14.15.10.444
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.444
4mihFADPyranose 2-oxidase1.1.3.100.444
4n9iPCGCatabolite expression activator/0.444
1a2nTETUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.443
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1qbqHFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.443
1qbqHFPProtein farnesyltransferase subunit beta2.5.1.580.443
2fhnBNIAvidin-related protein 4/5/0.443
2hk9NAPShikimate dehydrogenase (NADP(+))/0.443
2x0iNAIMalate dehydrogenase/0.443
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.443
2zbaZBATrichothecene 3-O-acetyltransferase/0.443
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.443
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
3iocA5DPantothenate synthetase6.3.2.10.443
3k7tFAD6-hydroxy-L-nicotine oxidase/0.443
3r96ACOMccE protein/0.443
3rn8RN8Glutamate receptor 2/0.443
3s79ASDAromatase1.14.14.140.443
3slkNDPPolyketide synthase extender module 2/0.443
4dpi0N1Beta-secretase 13.4.23.460.443
4dptAGSMevalonate diphosphate decarboxylase/0.443
4dpuAGSMevalonate diphosphate decarboxylase/0.443
4dpy2P0Mevalonate diphosphate decarboxylase/0.443
4ebfNADPhosphonate dehydrogenase1.20.1.10.443
4ikeADPAdenylate kinase/0.443
4ly91YYGlucokinase regulatory protein/0.443
5cflC2EStimulator of interferon genes protein/0.443
6req3CPMethylmalonyl-CoA mutase large subunit5.4.99.20.443
1bil0IURenin3.4.23.150.442
1m78NDPDihydrofolate reductase1.5.1.30.442
1ndhFADNADH-cytochrome b5 reductase 31.6.2.20.442
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.442
1u54ACPActivated CDC42 kinase 1/0.442
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.442
1w5tANPORC1-type DNA replication protein 2/0.442
1wzeNADMalate dehydrogenase/0.442
1ypeUIPProthrombin3.4.21.50.442
2cy0NAPShikimate dehydrogenase (NADP(+))/0.442
2d29FADAcyl-CoA dehydrogenase/0.442
2gcgNDPGlyoxylate reductase/hydroxypyruvate reductase1.1.1.790.442
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.442
2o12FMNChorismate synthase/0.442
2o7oDXTTetracycline repressor protein class D/0.442
2qo9ANPEphrin type-A receptor 32.7.10.10.442
2rlcCHDCholoylglycine hydrolase3.5.1.240.442
2v3oI26Prothrombin3.4.21.50.442
2zjmF1MBeta-secretase 13.4.23.460.442
3nsh957Beta-secretase 13.4.23.460.442
3oev3OEProteasome subunit beta type-53.4.25.10.442
3oev3OEProteasome subunit beta type-63.4.25.10.442
3phjDHKShikimate dehydrogenase (NADP(+))/0.442
3qbhQBHBeta-secretase 13.4.23.460.442
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.442
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4fv7E94Mitogen-activated protein kinase 12.7.11.240.442
4ge90L0Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.442
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.442
4i0i957Beta-secretase 13.4.23.460.442
4i13FOLDihydrofolate reductase1.5.1.30.442
4udrFAD5-(hydroxymethyl)furfural oxidase/0.442
4z24FADPutative GMC-type oxidoreductase R13510.442
5fklTDCTetracycline repressor protein class D/0.442
1gv0NADMalate dehydrogenase/0.441
1hfqMOTDihydrofolate reductase1.5.1.30.441
1icuFMNOxygen-insensitive NAD(P)H nitroreductase/0.441
1jqiCAAShort-chain specific acyl-CoA dehydrogenase, mitochondrial/0.441
1pdhFASp-hydroxybenzoate hydroxylase/0.441
1rfuADPPyridoxal kinase2.7.1.350.441
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
1yreCOAUncharacterized protein/0.441
1zdwFLVPrenyltransferase/0.441
2b53D23Cyclin-dependent kinase 22.7.11.220.441
2e20B4PPropionate kinase/0.441
2ft9CHDFatty acid-binding protein 2, liver/0.441
2g1s4IGRenin3.4.23.150.441
2g8yNADHydroxycarboxylate dehydrogenase B/0.441
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.441
2ieaTDPPyruvate dehydrogenase E1 component1.2.4.10.441
2iyfERYOleandomycin glycosyltransferase2.4.10.441
2p2qPRXAcetyl-coenzyme A synthetase/0.441
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.441
2q5g1FAPeroxisome proliferator-activated receptor delta/0.441
2vj6VG5Beta-secretase 13.4.23.460.441
3bv2P38Mitogen-activated protein kinase 14/0.441
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
3dmeFADPutative conserved exported protein/0.441
3itjFADThioredoxin reductase 11.8.1.90.441
3kb6NADD-lactate dehydrogenase/0.441
3lpiZ74Beta-secretase 13.4.23.460.441
3mvqNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.441
3ooiSAMHistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific2.1.1.430.441
3p8jFMNPentaerythritol tetranitrate reductase/0.441
3udq09EBeta-secretase 13.4.23.460.441
3uovFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.441
4dbzNDPPutative ketoacyl reductase1.3.10.441
4h0uUMPThymidylate synthase/0.441
4h1vGNPDynamin-1-like protein3.6.5.50.441
4ho4THMGlucose-1-phosphate thymidylyltransferase/0.441
4jqlVJ6Heat shock protein HSP 90-alpha/0.441
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.441
4mv1ADPBiotin carboxylase6.3.4.140.441
4n82FMNRibonucleotide reductase (NrdI family protein), putative/0.441
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.441
4u7wNDPMxaA/0.441
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.441
5jscFADPutative acyl-CoA dehydrogenase/0.441
1a72PADAlcohol dehydrogenase E chain1.1.1.10.440
1d3dBZTProthrombin3.4.21.50.440
1l7x700Glycogen phosphorylase, liver form2.4.1.10.440
1od10QSEndothiapepsin3.4.23.220.440
1umaIN2Prothrombin3.4.21.50.440
1xjqADPBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 12.7.1.250.440
2af3COAPhosphate acetyltransferase2.3.1.80.440
2am22LGUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.440
2c20NADUDP-glucose 4-epimerase/0.440
2daaDCSD-alanine aminotransferase2.6.1.210.440
2gjnFMNNitronate monooxygenase1.13.12.160.440
2j07HDFDeoxyribodipyrimidine photo-lyase4.1.99.30.440
2rkvZBATrichothecene 3-O-acetyltransferase/0.440
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.440
3bm1FMNPutative NAD(P)H nitroreductase YdjA/0.440
3bpzCMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2/0.440
3e2sFADBifunctional protein PutA1.5.5.20.440
3ekuCY9Actin-5C/0.440
3f63GTXGlutathione transferase GST1-4/0.440
3fwgCAMCamphor 5-monooxygenase1.14.15.10.440
3h3sH15Collagen type IV alpha-3-binding protein/0.440
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.440
4brdANPEctonucleoside triphosphate diphosphohydrolase I/0.440
4fmxCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.440
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.440
4l4dCAMCamphor 5-monooxygenase1.14.15.10.440
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.440
4wfr2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.440
5ej8TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.440