sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3wyp | BSO | Streptavidin |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3wyp | BSO | Streptavidin | / | 1.000 | |
| 1nc9 | IMI | Streptavidin | / | 0.636 | |
| 1ndj | BTN | Streptavidin | / | 0.616 | |
| 2zsc | BTN | Tamavidin2 | / | 0.602 | |
| 2izk | GLL | Streptavidin | / | 0.589 | |
| 1swp | BTQ | Streptavidin | / | 0.587 | |
| 1swn | BTN | Streptavidin | / | 0.583 | |
| 2izf | BTN | Streptavidin | / | 0.574 | |
| 2avi | BTN | Avidin | / | 0.573 | |
| 4ggz | BTN | Bll1558 protein | / | 0.573 | |
| 1mk5 | BTN | Streptavidin | / | 0.568 | |
| 1mep | BTN | Streptavidin | / | 0.561 | |
| 1sri | DMB | Streptavidin | / | 0.560 | |
| 1sre | HAB | Streptavidin | / | 0.558 | |
| 2izh | BTN | Streptavidin | / | 0.556 | |
| 2rtn | IMI | Streptavidin | / | 0.553 | |
| 1swd | BTN | Streptavidin | / | 0.552 | |
| 1n9m | BTN | Streptavidin | / | 0.551 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.548 | |
| 2rto | IMI | Streptavidin | / | 0.547 | |
| 1stp | BTN | Streptavidin | / | 0.546 | |
| 1srf | MTB | Streptavidin | / | 0.545 | |
| 1srg | MHB | Streptavidin | / | 0.545 | |
| 2rtr | IMI | Streptavidin | / | 0.543 | |
| 2izl | IMI | Streptavidin | / | 0.542 | |
| 4dne | DTB | Streptavidin | / | 0.542 | |
| 3ry2 | BTN | Streptavidin | / | 0.541 | |
| 3wyq | BTN | Streptavidin | / | 0.539 | |
| 2rtg | BTN | Streptavidin | / | 0.535 | |
| 2rtf | BTN | Streptavidin | / | 0.532 | |
| 4bx7 | B4F | Streptavidin | / | 0.532 | |
| 1i9h | BNI | Streptavidin | / | 0.531 | |
| 2y3f | BTN | Streptavidin | / | 0.531 | |
| 1lcw | SHM | Streptavidin | / | 0.530 | |
| 1avd | BTN | Avidin | / | 0.528 | |
| 2rti | GLL | Streptavidin | / | 0.525 | |
| 2rtk | GLL | Streptavidin | / | 0.525 | |
| 2rtd | BTN | Streptavidin | / | 0.524 | |
| 1df8 | BTN | Streptavidin | / | 0.522 | |
| 3vgw | NVZ | Avidin | / | 0.522 | |
| 2rtm | IMI | Streptavidin | / | 0.520 | |
| 2rtq | IMI | Streptavidin | / | 0.514 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.511 | |
| 2rte | BTN | Streptavidin | / | 0.507 | |
| 4gda | BTN | Streptavidin | / | 0.507 | |
| 2bfq | AR6 | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.506 | |
| 1luq | BTN | Streptavidin | / | 0.505 | |
| 3vhh | VHH | Avidin | / | 0.505 | |
| 1swt | BTN | Streptavidin | / | 0.503 | |
| 4z28 | BTN | Hoefavidin | / | 0.503 | |
| 2izg | BTN | Streptavidin | / | 0.502 | |
| 3ew2 | BTN | Hypothetical conserved protein | / | 0.497 | |
| 2uz2 | BTN | Avd protein | / | 0.496 | |
| 4bj8 | BTN | Avidin | / | 0.496 | |
| 4v2g | CTC | Tetracycline repressor protein class D | / | 0.496 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.495 | |
| 1srh | MOB | Streptavidin | / | 0.495 | |
| 1srj | NAB | Streptavidin | / | 0.493 | |
| 2r2m | I50 | Prothrombin | 3.4.21.5 | 0.492 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.490 | |
| 1rxh | BNI | Streptavidin | / | 0.490 | |
| 1y52 | BTN | Avidin-related protein 4/5 | / | 0.490 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.490 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.490 | |
| 1lcz | BH7 | Streptavidin | / | 0.489 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.489 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.489 | |
| 1afe | ALZ | Prothrombin | 3.4.21.5 | 0.488 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.487 | |
| 1zrb | 062 | Prothrombin | 3.4.21.5 | 0.487 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.487 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.487 | |
| 2anm | CDO | Prothrombin | 3.4.21.5 | 0.485 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.484 | |
| 2uyw | BTN | Avd protein | / | 0.484 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.484 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.483 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.483 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.482 | |
| 2dr8 | CTP | CCA-adding enzyme | 2.7.7.72 | 0.482 | |
| 2rtp | IMI | Streptavidin | / | 0.482 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.482 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.482 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.482 | |
| 1ae8 | AZL | Prothrombin | 3.4.21.5 | 0.481 | |
| 1d9i | 00P | Prothrombin | 3.4.21.5 | 0.481 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.481 | |
| 5fkk | TDC | Tetracycline repressor protein class D | / | 0.481 | |
| 1a4w | QWE | Prothrombin | 3.4.21.5 | 0.480 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.480 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.479 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.479 | |
| 1uma | IN2 | Prothrombin | 3.4.21.5 | 0.479 | |
| 3biu | 10U | Prothrombin | 3.4.21.5 | 0.479 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.479 | |
| 1t4u | 81A | Prothrombin | 3.4.21.5 | 0.478 | |
| 3dzi | RGT | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.478 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.477 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.477 | |
| 4eqs | COA | Coenzyme A disulfide reductase | / | 0.477 | |
| 4o9c | COA | Acetyl-CoA acetyltransferase | 2.3.1.9 | 0.477 | |
| 4xo7 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.477 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.477 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.477 | |
| 1oyt | FSN | Prothrombin | 3.4.21.5 | 0.476 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.476 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.476 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.476 | |
| 3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.476 | |
| 4bcs | BTN | Avidin-related protein 4/5 | / | 0.476 | |
| 4gyy | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.476 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.476 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.475 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.475 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.475 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.475 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.475 | |
| 1d8f | SPI | Stromelysin-1 | 3.4.24.17 | 0.474 | |
| 1fvp | FMA | Non-fluorescent flavoprotein | / | 0.474 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 1vzq | SHY | Prothrombin | 3.4.21.5 | 0.474 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.474 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.473 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.473 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.473 | |
| 2cmf | F11 | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
| 3glu | LYS_VAL_MET | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.473 | |
| 3t2w | BTN | Avidin/streptavidin | / | 0.473 | |
| 4rrd | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.473 | |
| 5cb3 | APR | O-acetyl-ADP-ribose deacetylase | / | 0.473 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.473 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.472 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.472 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.472 | |
| 2hl0 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.472 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.472 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.472 | |
| 3hat | GLY_VAL_ARG_RNG | Prothrombin | 3.4.21.5 | 0.472 | |
| 3wzn | BTN | Streptavidin | / | 0.472 | |
| 4dpe | NGH | Stromelysin-1 | 3.4.24.17 | 0.472 | |
| 1cbf | SAH | Cobalt-precorrin-4 C(11)-methyltransferase | 2.1.1.271 | 0.471 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.471 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.471 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.471 | |
| 1bux | PPS | Nucleoside diphosphate kinase, cytosolic | 2.7.4.6 | 0.470 | |
| 1gve | NAP | Aflatoxin B1 aldehyde reductase member 3 | 1 | 0.470 | |
| 1ype | UIP | Prothrombin | 3.4.21.5 | 0.470 | |
| 1yzq | GNP | Ras-related protein Rab-6A | / | 0.470 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.470 | |
| 2fhl | BNI | Avidin-related protein 4/5 | / | 0.470 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.470 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.470 | |
| 5ch7 | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.470 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.470 | |
| 1ogi | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.469 | |
| 2vcz | VC3 | Hematopoietic prostaglandin D synthase | / | 0.469 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.469 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.469 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.469 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.469 | |
| 4l4x | NDP | AmphI | / | 0.469 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.468 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.468 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.468 | |
| 2tct | CTC | Tetracycline repressor protein class D | / | 0.468 | |
| 1e2n | RCA | Thymidine kinase | / | 0.467 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.467 | |
| 2jgs | BTN | Avidin | / | 0.467 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.467 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.467 | |
| 3nmh | PYV | Abscisic acid receptor PYL2 | / | 0.467 | |
| 3utu | 1TS | Prothrombin | 3.4.21.5 | 0.467 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.467 | |
| 1m9h | NAD | 2,5-diketo-D-gluconic acid reductase A | 1.1.1.346 | 0.466 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 1yry | MSG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.466 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.466 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.466 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.466 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.466 | |
| 3dux | 64U | Prothrombin | 3.4.21.5 | 0.465 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.465 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.465 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.465 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.465 | |
| 4nbi | D3Y | D-tyrosyl-tRNA(Tyr) deacylase | / | 0.465 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.464 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.464 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.464 | |
| 3ozc | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.464 | |
| 4uyg | 73B | Bromodomain-containing protein 2 | / | 0.464 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.464 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.463 | |
| 2ejz | SAH | Diphthine synthase | / | 0.463 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.463 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.463 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.463 | |
| 2z3n | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.463 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.463 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.463 | |
| 4kxj | P34 | Nucleoprotein | / | 0.463 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.463 | |
| 1mu6 | CDA | Prothrombin | 3.4.21.5 | 0.462 | |
| 1v0j | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.462 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.462 | |
| 2bfr | ADP | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.462 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.462 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.462 | |
| 4mry | CEI | Obelin | / | 0.462 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.461 | |
| 2r8o | T5X | Transketolase 1 | / | 0.461 | |
| 2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.461 | |
| 2xnv | VU3 | Soluble acetylcholine receptor | / | 0.461 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.461 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.461 | |
| 4ayy | 9MX | Prothrombin | 3.4.21.5 | 0.461 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.461 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.461 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.461 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.461 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.461 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.460 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.460 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.460 | |
| 2izi | BTN | Streptavidin | / | 0.460 | |
| 2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.460 | |
| 2o7o | DXT | Tetracycline repressor protein class D | / | 0.460 | |
| 2v3o | I26 | Prothrombin | 3.4.21.5 | 0.460 | |
| 2wmd | ZZ0 | NmrA-like family domain-containing protein 1 | / | 0.460 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.460 | |
| 4ax9 | N5N | Prothrombin | 3.4.21.5 | 0.460 | |
| 4epq | 0RR | Poly(ADP-ribose) glycohydrolase | / | 0.460 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.459 | |
| 1gpu | THD | Transketolase 1 | 2.2.1.1 | 0.459 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.459 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.459 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.459 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.459 | |
| 2wwj | Y28 | Lysine-specific demethylase 4A | / | 0.459 | |
| 2xrl | DXT | Tetracycline repressor protein class D | / | 0.459 | |
| 3cwq | ADP | ParA family chromosome partitioning protein | / | 0.459 | |
| 3e6e | DCS | Alanine racemase | / | 0.459 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.459 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.459 | |
| 4k8s | 1QT | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.459 | |
| 4xyb | NDP | Formate dehydrogenase | / | 0.459 | |
| 4n4w | SNT | Smoothened homolog | / | 0.459 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.458 | |
| 1ogj | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.458 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.458 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.458 | |
| 2mm3 | CHO | Gastrotropin | / | 0.458 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.458 | |
| 2zhe | 13U | Prothrombin | 3.4.21.5 | 0.458 | |
| 2zit | NAD | Exotoxin A | 2.4.2.36 | 0.458 | |
| 3ae4 | N1M | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | 1.3.5.1 | 0.458 | |
| 3ae4 | N1M | Succinate dehydrogenase cytochrome b560 subunit, mitochondrial | / | 0.458 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.458 | |
| 3q6k | SRO | 43.2 kDa salivary protein | / | 0.458 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.458 | |
| 3tx1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.458 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.458 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.458 | |
| 4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.458 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.458 | |
| 4bue | JQF | Tankyrase-2 | 2.4.2.30 | 0.458 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.458 | |
| 4tjy | 3GN | Tankyrase-2 | 2.4.2.30 | 0.458 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.458 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.457 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.457 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.457 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.457 | |
| 1rxj | BNI | Streptavidin | / | 0.457 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.457 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.457 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.457 | |
| 2vqb | FAD | Putative flavin-containing monooxygenase | / | 0.457 | |
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 | 0.457 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.457 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.457 | |
| 3i28 | 34N | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.457 | |
| 3klb | FMN | Uncharacterized protein | / | 0.457 | |
| 3ndj | JHZ | Methyltransferase | / | 0.457 | |
| 3vhm | NPK | Avidin | / | 0.457 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.457 | |
| 4dz5 | NAP | Aldo-keto reductase family 1 member C3 | / | 0.457 | |
| 4n3c | UD1 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.457 | |
| 4wx2 | F6F | Tryptophan synthase alpha chain | / | 0.457 | |
| 4wx2 | F6F | Tryptophan synthase beta chain | 4.2.1.20 | 0.457 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.456 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.456 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.456 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.456 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.456 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.456 | |
| 1ta6 | 177 | Prothrombin | 3.4.21.5 | 0.456 | |
| 1ye6 | NAP | NAD(P)H-dependent D-xylose reductase | 1.1.1.307 | 0.456 | |
| 2bxt | C2D | Prothrombin | 3.4.21.5 | 0.456 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.456 | |
| 3cgc | COA | Coenzyme A disulfide reductase | / | 0.456 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.456 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.456 | |
| 3pd4 | A3G | Threonine--tRNA ligase | 6.1.1.3 | 0.456 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.456 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 4l09 | 1UR | Tankyrase-2 | 2.4.2.30 | 0.456 | |
| 4s26 | SAH | Phosphomethylpyrimidine synthase, chloroplastic | 4.1.99.17 | 0.456 | |
| 4wh3 | ATP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.456 | |
| 1d4p | BPP | Prothrombin | 3.4.21.5 | 0.455 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.455 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 1lke | DOG | Bilin-binding protein | / | 0.455 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2bjh | FER | Feruloyl esterase A | 3.1.1.73 | 0.455 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.455 | |
| 2c4i | BTN | Avidin | / | 0.455 | |
| 2r8p | T6F | Transketolase 1 | / | 0.455 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.455 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.455 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 3gqo | APR | Non-structural polyprotein | / | 0.455 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.455 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.455 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.455 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.455 | |
| 4er7 | AW3 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.455 | |
| 4i4b | 1CV | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.455 | |
| 4i5e | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.455 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.455 | |
| 4nbj | D3Y | D-tyrosyl-tRNA(Tyr) deacylase | / | 0.455 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.455 | |
| 4z87 | GDP | Inosine-5'-monophosphate dehydrogenase | / | 0.455 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.454 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.454 | |
| 2ohv | NHL | Glutamate racemase | / | 0.454 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.454 | |
| 2yk2 | YJW | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.454 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.454 | |
| 3r5y | F42 | Uncharacterized protein | / | 0.454 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.454 | |
| 4e32 | DWN | Methyltransferase | / | 0.454 | |
| 4m37 | SAH | Protein arginine N-methyltransferase 7 | 2.1.1 | 0.454 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.454 | |
| 1ghv | 120 | Prothrombin | 3.4.21.5 | 0.453 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.453 | |
| 1mma | ADP | Myosin-2 heavy chain | / | 0.453 | |
| 1wl4 | COA | Acetyl-CoA acetyltransferase, cytosolic | 2.3.1.9 | 0.453 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.453 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.453 | |
| 2eka | SAH | Diphthine synthase | / | 0.453 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.453 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.453 | |
| 2vr1 | ATF | Biotin carboxylase | 6.3.4.14 | 0.453 | |
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 2xje | U5P | Cytosolic purine 5'-nucleotidase | 3.1.3.5 | 0.453 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2zfq | 45U | Prothrombin | 3.4.21.5 | 0.453 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.453 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.453 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.453 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.453 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.453 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.453 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.453 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.453 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1k22 | MEL | Prothrombin | 3.4.21.5 | 0.452 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.452 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.452 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.452 | |
| 1piw | NAP | NADP-dependent alcohol dehydrogenase 6 | 1.1.1.2 | 0.452 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2r2n | KYN | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.452 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.452 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.452 | |
| 3mte | SAM | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.452 | |
| 3up0 | D7S | aceDAF-12 | / | 0.452 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.452 | |
| 4bam | MM9 | Prothrombin | 3.4.21.5 | 0.452 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.452 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 4d96 | 5PA | D-cysteine desulfhydrase | / | 0.452 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.452 | |
| 4hxy | NDP | Plm1 | / | 0.452 | |
| 4x5h | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1i59 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.451 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 2fjd | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.451 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.451 | |
| 2zgb | 21U | Prothrombin | 3.4.21.5 | 0.451 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.451 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.451 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.451 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.451 | |
| 4aos | FAD | Steroid monooxygenase | / | 0.451 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.451 | |
| 1a80 | NDP | 2,5-diketo-D-gluconic acid reductase A | 1.1.1.346 | 0.450 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.450 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.450 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.450 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.450 | |
| 1o5g | CR9 | Prothrombin | 3.4.21.5 | 0.450 | |
| 1pwy | AC2 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.450 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.450 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.450 | |
| 2q3o | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.450 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.450 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 3eku | CY9 | Actin-5C | / | 0.450 | |
| 3gxf | IFM | Glucosylceramidase | 3.2.1.45 | 0.450 | |
| 3hgs | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.450 | |
| 3hky | IX6 | Genome polyprotein | 2.7.7.48 | 0.450 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.450 | |
| 3rdq | DTB | Streptavidin | / | 0.450 | |
| 3uqd | ADP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.450 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.450 | |
| 4eqr | COA | Coenzyme A disulfide reductase | / | 0.450 | |
| 4iei | ADP | Gene 2 protein | / | 0.450 | |
| 4o7n | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | 6.3.2.6 | 0.450 | |
| 4rr7 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.450 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.450 | |
| 1bmd | NAD | Malate dehydrogenase | / | 0.449 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.449 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.449 | |
| 1ow3 | GDP | Transforming protein RhoA | / | 0.449 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.449 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.449 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2aj4 | ANP | Galactokinase | 2.7.1.6 | 0.449 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 2fjb | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.449 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.449 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.449 | |
| 2x6o | 2TC | Tetracycline repressor protein class D | / | 0.449 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.449 | |
| 2zru | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.449 | |
| 3hy9 | 098 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.449 | |
| 3v0t | ATR | Perakine reductase | 1.1.1.317 | 0.449 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.449 | |
| 4meo | 25V | Bromodomain-containing protein 4 | / | 0.449 | |
| 4mr5 | 1K0 | Bromodomain-containing protein 2 | / | 0.449 | |
| 4ne0 | ZZU | Hydroxylase | / | 0.449 | |
| 4ynt | FDA | Glucose oxidase, putative | / | 0.449 | |
| 1c4y | IH3 | Prothrombin | 3.4.21.5 | 0.448 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.448 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.448 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.448 | |
| 1u30 | GOX | Pancreatic alpha-amylase | / | 0.448 | |
| 1uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.448 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 2aba | STR | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.448 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.448 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.448 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.448 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.448 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.448 | |
| 3gtc | GTC | Beta-lactamase | 3.5.2.6 | 0.448 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.448 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.448 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3p17 | 99P | Prothrombin | 3.4.21.5 | 0.448 | |
| 3s2u | UD1 | UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase | / | 0.448 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.448 | |
| 4j7h | TRH | PCZA361.3 | / | 0.448 | |
| 4kzl | 20D | Tankyrase-2 | 2.4.2.30 | 0.448 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.448 | |
| 4ttj | FMC | Purine nucleoside phosphorylase DeoD-type | / | 0.448 | |
| 4ubv | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.448 | |
| 3vw7 | VPX | Proteinase-activated receptor 1 | / | 0.448 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.447 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.447 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.447 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1ra3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.447 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.447 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 2f3e | AXQ | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2xpv | MIY | Tetracycline repressor protein class D | / | 0.447 | |
| 2xvh | FAD | Putative flavin-containing monooxygenase | / | 0.447 | |
| 3gb4 | D3M | DdmC | / | 0.447 | |
| 3hy7 | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.447 | |
| 3pi0 | F91 | Endothiapepsin | 3.4.23.22 | 0.447 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.447 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.447 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4c73 | TLH | 3-oxoacyl-ACP synthase | / | 0.447 | |
| 4d9f | DCS | D-cysteine desulfhydrase | / | 0.447 | |
| 4du6 | GTP | GTP cyclohydrolase 1 | / | 0.447 | |
| 4eqw | COA | Coenzyme A disulfide reductase | / | 0.447 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 4l1x | NAP | Aldo-keto reductase family 1 member C2 | / | 0.447 | |
| 4xw4 | ANP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 4zu4 | 4TG | WxcM-like protein | / | 0.447 | |
| 5cb5 | APR | O-acetyl-ADP-ribose deacetylase | / | 0.447 | |
| 5fuv | THM | Thymidine kinase, putative | / | 0.447 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.447 | |
| 1bcu | PRL | Prothrombin | 3.4.21.5 | 0.446 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.446 | |
| 1m67 | BOA | Glycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal | 1.1.1.8 | 0.446 | |
| 1m9n | AMZ | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.446 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.446 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.446 | |
| 1xzq | FON | tRNA modification GTPase MnmE | 3.6.5 | 0.446 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2trt | TAC | Tetracycline repressor protein class D | / | 0.446 | |
| 2vht | ATP | NTPase P4 | / | 0.446 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.446 | |
| 3rim | TPP | Transketolase | 2.2.1.1 | 0.446 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.446 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.446 | |
| 4f0e | 0RU | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.446 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.446 | |
| 5c3r | HMU | Thymine dioxygenase | / | 0.446 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.445 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 1ikg | REX | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.445 | |
| 1k4h | APQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.445 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.445 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1rgs | CMP | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.445 | |
| 1rkp | IBM | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.445 | |
| 1txz | APR | Probable ADP-ribose 1''-phosphate phosphatase YML087W | 3.1.3.84 | 0.445 | |
| 1u28 | NAP | NAD(P) transhydrogenase subunit beta | 1.6.1.2 | 0.445 | |
| 1wxj | IPL | Tryptophan synthase alpha chain | / | 0.445 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.445 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.445 | |
| 3ab1 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.445 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.445 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.445 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.445 | |
| 3nd6 | ATP | Phosphopantetheine adenylyltransferase | / | 0.445 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.445 | |
| 3ppo | DCK | Glycine betaine/carnitine/choline-binding protein OpuCC | / | 0.445 | |
| 3rno | NAP | NAD(P)H-hydrate epimerase | 5.1.99.6 | 0.445 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.445 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.444 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1ppj | ANY | Cytochrome b | / | 0.444 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.444 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.444 | |
| 1sqi | 869 | 4-hydroxyphenylpyruvate dioxygenase | / | 0.444 | |
| 1xk9 | P34 | Exotoxin A | 2.4.2.36 | 0.444 | |
| 2cf8 | ESH | Prothrombin | 3.4.21.5 | 0.444 | |
| 2jj8 | AZZ | Deoxynucleoside kinase | / | 0.444 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.444 | |
| 3c27 | DKK | Prothrombin | 3.4.21.5 | 0.444 | |
| 3cb2 | GDP | Tubulin gamma-1 chain | / | 0.444 | |
| 3ehj | ACP | Sensor histidine kinase DesK | 2.7.13.3 | 0.444 | |
| 3k4c | FAD | Pyranose 2-oxidase | / | 0.444 | |
| 3mje | NDP | AmphB | / | 0.444 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.444 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.444 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.444 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.444 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.444 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.444 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.444 | |
| 4prv | ADP | DNA gyrase subunit B | / | 0.444 | |
| 5fkm | TDC | Tetracycline repressor protein class D | / | 0.444 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.444 | |
| 1a4l | DCF | Adenosine deaminase | 3.5.4.4 | 0.443 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1g2v | TTP | Glucose-1-phosphate thymidylyltransferase | / | 0.443 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.443 | |
| 1ngs | TPP | Transketolase 1 | 2.2.1.1 | 0.443 | |
| 1nmk | SFM | Peptidyl-prolyl cis-trans isomerase A | 5.2.1.8 | 0.443 | |
| 1tkg | SSA | Threonine--tRNA ligase | 6.1.1.3 | 0.443 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 1xdy | MTE | Protein-methionine-sulfoxide reductase catalytic subunit MsrP | / | 0.443 | |
| 1xg5 | NAP | Dehydrogenase/reductase SDR family member 11 | / | 0.443 | |
| 2b4y | APR | NAD-dependent protein deacylase sirtuin-5, mitochondrial | / | 0.443 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.443 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.443 | |
| 2jh6 | 894 | Prothrombin | 3.4.21.5 | 0.443 | |
| 2ohh | FMN | Type A flavoprotein FprA | 1 | 0.443 | |
| 2v3h | I25 | Prothrombin | 3.4.21.5 | 0.443 | |
| 2vq7 | FAD | Putative flavin-containing monooxygenase | / | 0.443 | |
| 2wnb | C5P | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 | 2.4.99.4 | 0.443 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.443 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 3fvl | BHK | Carboxypeptidase A1 | 3.4.17.1 | 0.443 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.443 | |
| 3kdt | 7HA | Peroxisome proliferator-activated receptor alpha | / | 0.443 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.443 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.443 | |
| 3wag | TYD | Glycosyltransferase | / | 0.443 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.443 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.443 | |
| 4j7g | TRH | PCZA361.3 | / | 0.443 | |
| 4kwh | NAP | Reductase homolog | / | 0.443 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.443 | |
| 4py0 | 6AT | P2Y purinoceptor 12 | / | 0.443 | |
| 1dd6 | MCI | Metallo-beta-lactamase type 2 | / | 0.442 | |
| 1nbu | PH2 | Dihydroneopterin aldolase | / | 0.442 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.442 | |
| 2cn0 | F25 | Prothrombin | 3.4.21.5 | 0.442 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.442 | |
| 2hq9 | FAD | Mll6688 protein | / | 0.442 | |
| 2ofv | 242 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.442 | |
| 2pa3 | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.442 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.442 | |
| 2qta | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.442 | |
| 2qtc | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.442 | |
| 2rd5 | NLG | Acetylglutamate kinase, chloroplastic | 2.7.2.8 | 0.442 | |
| 2vxk | COA | Glucosamine 6-phosphate acetyltransferase, putative | / | 0.442 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3daa | PDD | D-alanine aminotransferase | 2.6.1.21 | 0.442 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 3k45 | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3ov7 | ATP | CCA-adding enzyme | 2.7.7.72 | 0.442 | |
| 3uix | Q17 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 3uwl | FOZ | Thymidylate synthase | / | 0.442 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.442 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.442 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.442 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 4nmc | FAD | Bifunctional protein PutA | / | 0.442 | |
| 5c7h | NDP | Putative oxidoreductase | / | 0.442 | |
| 5egh | PC | Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 | / | 0.442 | |
| 1c1u | BAI | Prothrombin | 3.4.21.5 | 0.441 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.441 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.441 | |
| 1e92 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.441 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1i7l | ATP | Synapsin-2 | / | 0.441 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.441 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 1kw9 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.441 | |
| 1n08 | ADP | Riboflavin kinase | 2.7.1.26 | 0.441 | |
| 1pw1 | HEL | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.441 | |
| 1zm4 | TAD | Exotoxin A | 2.4.2.36 | 0.441 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.441 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2hp2 | KE4 | Glutamate-1-semialdehyde 2,1-aminomutase | 5.4.3.8 | 0.441 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.441 | |
| 2zgx | 29U | Prothrombin | 3.4.21.5 | 0.441 | |
| 3bbr | BHY | Glutamate receptor 2 | / | 0.441 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3tye | XTZ | Dihydropteroate synthase | / | 0.441 | |
| 3x04 | GNP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.441 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.441 | |
| 4cfa | WOP | Integrase | / | 0.441 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.441 | |
| 4rrm | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.441 | |
| 4rrx | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.441 | |
| 4u9v | ACO | N-alpha-acetyltransferase 40 | 2.3.1 | 0.441 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.441 | |
| 5fuw | THM | Thymidine kinase, putative | / | 0.441 | |
| 1aiq | CB3 | Thymidylate synthase | / | 0.440 | |
| 1aj2 | 2PH | Dihydropteroate synthase | / | 0.440 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1ecb | 5GP | Amidophosphoribosyltransferase | / | 0.440 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1kmy | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.440 | |
| 1mtc | GPR | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.440 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.440 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.440 | |
| 2izj | BTN | Streptavidin | / | 0.440 | |
| 2jh5 | 895 | Prothrombin | 3.4.21.5 | 0.440 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.440 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 2w6m | OA1 | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 2yd0 | BES | Endoplasmic reticulum aminopeptidase 1 | 3.4.11 | 0.440 | |
| 3c1o | NAP | Eugenol synthase | / | 0.440 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.440 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.440 | |
| 3ko5 | ADP | D-tyrosyl-tRNA(Tyr) deacylase | / | 0.440 | |
| 3nx2 | FER | Ferulic acid decarboxylase | / | 0.440 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3tvq | DQH | Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN | 2.1.1 | 0.440 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.440 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.440 | |
| 3vv8 | B02 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 4aux | XTC | Tetracycline repressor protein class D | / | 0.440 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.440 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.440 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.440 | |
| 4kqq | VPP | Peptidoglycan D,D-transpeptidase FtsI | / | 0.440 | |
| 4mo2 | FDA | UDP-galactopyranose mutase | / | 0.440 | |
| 4mwh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.440 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.440 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.440 |