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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5a9sNAPPutative dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5a9sNAPPutative dehydrogenase/1.000
2cy0NAPShikimate dehydrogenase (NADP(+))/0.517
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.516
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.512
1bwsNDPGDP-L-fucose synthase/0.510
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.510
4g7gVFVLanosterol 14-alpha-demethylase/0.510
2vn0TDZCytochrome P450 2C8/0.506
5c41ACPRibokinase/0.503
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.502
2ohvNHLGlutamate racemase/0.502
4q71FADBifunctional protein PutA/0.502
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.501
1xe55FEPlasmepsin-23.4.23.390.497
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.495
1kkq471Peroxisome proliferator-activated receptor alpha/0.495
1nvtNAPShikimate dehydrogenase (NADP(+))/0.492
4uymVOR14-alpha sterol demethylase Cyp51B/0.492
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.489
1u54ACPActivated CDC42 kinase 1/0.489
3f03FMNPentaerythritol tetranitrate reductase/0.488
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.488
3s1dZIRCytokinin dehydrogenase 11.5.99.120.487
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.486
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.486
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.485
1m13HYFNuclear receptor subfamily 1 group I member 2/0.484
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.484
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.484
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.484
2zbaZBATrichothecene 3-O-acetyltransferase/0.483
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.483
4nk92K5Fibroblast growth factor receptor 1/0.483
4v2gITCTetracycline repressor protein class D/0.483
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.483
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.481
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.481
3atzFMNProstaglandin F2a synthase/0.481
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.481
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.480
1fmlRTLRetinol dehydratase/0.480
2ejvNADL-threonine 3-dehydrogenase/0.480
3kb1ADPIron-sulfur cluster carrier protein/0.480
3oetNADErythronate-4-phosphate dehydrogenase/0.480
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.480
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.480
1ha3MAUElongation factor Tu-A/0.479
3gwfFADCyclohexanone monooxygenase/0.479
2dftADPShikimate kinase2.7.1.710.478
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.478
4g090VDHistidinol dehydrogenase/0.478
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.477
1xe65FPPlasmepsin-23.4.23.390.477
2gjlFMNNitronate monooxygenase1.13.12.160.477
2rh9IGPTryptophan synthase alpha chain/0.477
2znq401Peroxisome proliferator-activated receptor delta/0.477
3lqfNADGalactitol dehydrogenase/0.477
4ambDUDPutative glycosyl transferase/0.477
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.477
5ftfADPTPR domain protein/0.477
1x8lOXRRetinol dehydratase/0.476
2uxoTACHTH-type transcriptional regulator TtgR/0.476
3a1nNADNDP-sugar epimerase/0.476
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.476
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.476
1jioDEB6-deoxyerythronolide B hydroxylase/0.475
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.475
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.475
3uylTYDProbable NDP-rhamnosyltransferase/0.475
4m9aFDAAcyl-CoA dehydrogenase/0.475
1k7fIAVTryptophan synthase alpha chain/0.474
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.474
3oev3OEProteasome subunit beta type-53.4.25.10.474
3oev3OEProteasome subunit beta type-63.4.25.10.474
1h51FMNPentaerythritol tetranitrate reductase/0.473
3otbDGTProbable tRNA(His) guanylyltransferase2.7.7.790.473
3p74FMNPentaerythritol tetranitrate reductase/0.473
3p8jFMNPentaerythritol tetranitrate reductase/0.473
4qecNAPElxO/0.473
3docNADGlyceraldehyde-3-phosphate dehydrogenase/0.472
3p62FMNPentaerythritol tetranitrate reductase/0.472
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.472
1h50FMNPentaerythritol tetranitrate reductase/0.471
1h63FMNPentaerythritol tetranitrate reductase/0.471
2xa4AZ5Tyrosine-protein kinase JAK2/0.471
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.471
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.471
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.471
1bygSTUTyrosine-protein kinase CSK/0.470
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.470
4g74FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.470
3nutSAHPrecorrin-3 methylase/0.469
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.469
3r9uFADThioredoxin reductase/0.469
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.469
4q73FADBifunctional protein PutA/0.469
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.469
5d3qGDPDynamin-13.6.5.50.469
2y4gTIRTamL/0.468
3kp4MIITranscriptional regulator TcaR/0.468
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.468
1e7qNAPGDP-L-fucose synthase/0.467
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.467
2d29FADAcyl-CoA dehydrogenase/0.467
2he5NDPAldo-keto reductase family 1 member C211.1.10.467
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.467
3bc3OPTCathepsin L13.4.22.150.467
3d4pNADL-lactate dehydrogenase 11.1.1.270.467
3gwfNAPCyclohexanone monooxygenase/0.467
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.467
4ix6ADPUncharacterized protein/0.467
5einNAP[LysW]-L-2-aminoadipate 6-phosphate reductase/0.467
1x1aSAMC-20 methyltransferase/0.466
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.466
3b895GP16S rRNA methylase/0.466
3h3t16HCollagen type IV alpha-3-binding protein/0.466
3qt62P0Mevalonate diphosphate decarboxylase/0.466
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.466
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.465
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.465
3fwgCAMCamphor 5-monooxygenase1.14.15.10.465
3gkaFMNN-ethylmaleimide reductase/0.465
3zuyTCHTransporter/0.465
4a99FADTetX family tetracycline inactivation enzyme/0.465
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.465
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
4cdmFO1Deoxyribodipyrimidine photolyase/0.465
4oqyNDP(S)-imine reductase/0.465
5e8wSTUTGF-beta receptor type-12.7.11.300.465
1ia3TQ5Dihydrofolate reductase1.5.1.30.464
1rfvADPPyridoxal kinase2.7.1.350.464
1vyrFMNPentaerythritol tetranitrate reductase/0.464
1xddAAYIntegrin alpha-L/0.464
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.464
3gw9VNILanosterol 14-alpha-demethylase/0.464
3ibqATPPyridoxal kinase/0.464
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.464
4tuvCPZCytochrome P450 1191.140.464
1pmn984Mitogen-activated protein kinase 102.7.11.240.463
1r2jFADFkbI/0.463
1tqf32PBeta-secretase 13.4.23.460.463
1w6hTITPlasmepsin-23.4.23.390.463
2zdt46CMitogen-activated protein kinase 102.7.11.240.463
3phiNDPShikimate dehydrogenase (NADP(+))/0.463
4q72FADBifunctional protein PutA/0.463
4xiwAZMCarbonic anhydrase, alpha type/0.463
4z4pSAHHistone-lysine N-methyltransferase 2D2.1.1.430.463
1ee9NADMethylenetetrahydrofolate dehydrogenase [NAD(+)]1.5.1.150.462
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.462
2a1oCAMCamphor 5-monooxygenase1.14.15.10.462
2po7CHDFerrochelatase, mitochondrial4.99.1.10.462
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.462
3fwfCAMCamphor 5-monooxygenase1.14.15.10.462
3fwjCAMCamphor 5-monooxygenase1.14.15.10.462
4djaFAD(6-4) photolyase/0.462
5a3bAPRSIR2 family protein/0.462
5hs1VORLanosterol 14-alpha demethylase/0.462
1kfbIGPTryptophan synthase alpha chain/0.461
2g8yNADHydroxycarboxylate dehydrogenase B/0.461
2lfoGCHFatty acid-binding protein, liver/0.461
2oapANPType II secretion system protein (GspE-2)/0.461
2p33J07Mitogen-activated protein kinase 102.7.11.240.461
3etdNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.461
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.461
3t3c017Gag-Pol polyprotein3.4.23.160.461
4a6bQG8Gag-Pol polyprotein3.4.23.160.461
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.461
4g3jVNTLanosterol 14-alpha-demethylase/0.461
4ipw1G7Mycocyclosin synthase1.14.21.90.461
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.461
4xguADPPutative pachytene checkpoint protein 2/0.461
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.461
1beuIPLTryptophan synthase alpha chain/0.460
1rfuADPPyridoxal kinase2.7.1.350.460
2a94AP0L-lactate dehydrogenase1.1.1.270.460
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
2fj1CTCTetracycline repressor protein class D/0.460
2iko7IGRenin3.4.23.150.460
2qw034Z4-chlorobenzoyl CoA ligase/0.460
3pgqGY3Acetyl-CoA carboxylase/0.460
3tz3B36Acetyl-CoA carboxylase/0.460
4b1rITCTetracycline repressor protein class D/0.460
4jin1L7RIO-type serine/threonine-protein kinase Rio12.7.11.10.460
1k7l544Peroxisome proliferator-activated receptor alpha/0.459
1nooCAHCamphor 5-monooxygenase1.14.15.10.459
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.459
2yneNHWGlycylpeptide N-tetradecanoyltransferase/0.459
3hwrNDP2-dehydropantoate 2-reductase/0.459
3p84FMNPentaerythritol tetranitrate reductase/0.459
3u9eCOALmo1369 protein/0.459
4a8v2ANMajor pollen allergen Bet v 1-J/0.459
4cd2FOLDihydrofolate reductase1.5.1.30.459
4jqlVJ6Heat shock protein HSP 90-alpha/0.459
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.459
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.458
1cf3FADGlucose oxidase1.1.3.40.458
1ddrMTXDihydrofolate reductase1.5.1.30.458
1tehNADAlcohol dehydrogenase class-31.1.1.10.458
1zeoC01Peroxisome proliferator-activated receptor gamma/0.458
2jcvNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.458
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.458
3tjzGNPADP-ribosylation factor 1/0.458
3wrmCAMCamphor 5-monooxygenase1.14.15.10.458
3zhbNAPPutative dehydrogenase/0.458
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.458
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.458
4rnuFMNNADPH dehydrogenase 11.6.99.10.458
4yaoFMNNADPH--cytochrome P450 reductase/0.458
4ylfFADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog/0.458
1pjcNADAlanine dehydrogenase/0.457
2fb2SAMGTP 3',8-cyclase4.1.99.180.457
2i40BLZCyclin-dependent kinase 22.7.11.220.457
2vwqNAPGlucose 1-dehydrogenase/0.457
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.457
3lkiATPFructokinase/0.457
3wrjCAMCamphor 5-monooxygenase1.14.15.10.457
4a862ANMajor pollen allergen Bet v 1-A/0.457
4dbzNDPPutative ketoacyl reductase1.3.10.457
4dfrMTXDihydrofolate reductase1.5.1.30.457
4lcjNADC-terminal-binding protein 2/0.457
5cp4CAMCamphor 5-monooxygenase1.14.15.10.457
1h73ANPHomoserine kinase2.7.1.390.456
1jipKTN6-deoxyerythronolide B hydroxylase/0.456
1t85CAMCamphor 5-monooxygenase1.14.15.10.456
2g1y5IGRenin3.4.23.150.456
2hs6FMN12-oxophytodienoate reductase 31.3.1.420.456
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.456
2i3gNAPN-acetyl-gamma-glutamyl-phosphate reductase1.2.1.380.456
2qblCAMCamphor 5-monooxygenase1.14.15.10.456
2y3sTIRTamL/0.456
3c1y2BADNA integrity scanning protein DisA/0.456
3fwiCAMCamphor 5-monooxygenase1.14.15.10.456
3gfbNADL-threonine 3-dehydrogenase/0.456
3w1tWRODihydroorotate dehydrogenase (fumarate)1.3.98.10.456
4eudCOASuccinyl-CoA:acetate CoA-transferase/0.456
4jicFMNGTN Reductase/0.456
1f8fNADBenzyl alcohol dehydrogenase/0.455
1gqtACPRibokinase/0.455
1j21ATPArgininosuccinate synthase/0.455
1yonA2R2-dehydropantoate 2-reductase1.1.1.1690.455
2a5kAZPReplicase polyprotein 1ab3.4.220.455
2a87FADThioredoxin reductase1.8.1.90.455
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.455
2aqiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.455
2ptfFMNUncharacterized protein MTH_863/0.455
2werRDCATP-dependent molecular chaperone HSP82/0.455
2wf4ZY4Beta-secretase 13.4.23.460.455
2xpuTDCTetracycline repressor protein class D/0.455
3kpkFADSulfide-quinone reductase/0.455
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.455
3r83Z14Cyclin-dependent kinase 22.7.11.220.455
4e2bFMNDehydrogenase/0.455
4g6hNAIRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.455
4y8wSTRSteroid 21-hydroxylase/0.455
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.455
5eioNAP[LysW]-L-2-aminoadipate 6-phosphate reductase/0.455
1ddsMTXDihydrofolate reductase1.5.1.30.454
1gjvAGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial2.7.11.40.454
1udaUFGUDP-glucose 4-epimerase5.1.3.20.454
1yrdCAMCamphor 5-monooxygenase1.14.15.10.454
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.454
2bi4NADLactaldehyde reductase1.1.1.770.454
2iviACWIsopenicillin N synthase1.21.3.10.454
2y05RALProstaglandin reductase 1/0.454
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.454
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.454
3mdvCL6Cholesterol 24-hydroxylase/0.454
3p67FMNPentaerythritol tetranitrate reductase/0.454
4a30MYAGlycylpeptide N-tetradecanoyltransferase/0.454
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.454
4i1iNADMalate dehydrogenase/0.454
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.454
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.454
4yryFADGlutamate synthase, beta subunit/0.454
1fxsNAPGDP-L-fucose synthase/0.453
1galFADGlucose oxidase1.1.3.40.453
1hb1OCVIsopenicillin N synthase1.21.3.10.453
1kfcIPLTryptophan synthase alpha chain/0.453
2c27ACOMycothiol acetyltransferase2.3.1.1890.453
2gtbAZPOrf1ab polyprotein/0.453
2iwsNP4ATP-dependent molecular chaperone HSP82/0.453
2p5uNADUDP-glucose 4-epimerase/0.453
3w3oROEDihydroorotate dehydrogenase (fumarate)1.3.98.10.453
3wrhCAMCamphor 5-monooxygenase1.14.15.10.453
4cfaWOPIntegrase/0.453
4lk3NADUDP-glucuronic acid decarboxylase 14.1.1.350.453
4r20AERCytochrome P450 family 17 polypeptide 2/0.453
1dnpFADDeoxyribodipyrimidine photo-lyase4.1.99.30.452
1g6kNADGlucose 1-dehydrogenase1.1.1.470.452
1ma0NADAlcohol dehydrogenase class-31.1.1.10.452
1t88CAMCamphor 5-monooxygenase1.14.15.10.452
1u3cFADCryptochrome-1/0.452
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.452
2ev9NAPShikimate dehydrogenase (NADP(+))/0.452
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.452
2xfsJ01Uncharacterized protein/0.452
3a4vNADNDP-sugar epimerase/0.452
3flwFLWMitogen-activated protein kinase 14/0.452
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.452
3nl6TPSUncharacterized protein/0.452
4e5yNDPGDP-L-fucose synthase1.1.1.2710.452
4ejmNAPPutative zinc-binding dehydrogenase/0.452
4fmxCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.452
4g3rCAMCamphor 5-monooxygenase1.14.15.10.452
4ihl1F514-3-3 protein zeta/delta/0.452
4jhz1KVBeta-glucuronidase3.2.1.310.452
4ktl1CQCytochrome P450/0.452
4o1mNADEnoyl-acyl carrier reductase/0.452
1o76CAMCamphor 5-monooxygenase1.14.15.10.451
1qlhNADAlcohol dehydrogenase E chain1.1.1.10.451
1t87CAMCamphor 5-monooxygenase1.14.15.10.451
1y7lASN_LEU_ASN_ILECysteine synthase2.5.1.470.451
2e07SAHDiphthine synthase/0.451
2fznFADBifunctional protein PutA1.5.5.20.451
2ie0ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
2xpwOTCTetracycline repressor protein class D/0.451
3cscACOCitrate synthase, mitochondrial2.3.3.10.451
3dds26BGlycogen phosphorylase, liver form2.4.1.10.451
3fr5I4AFatty acid-binding protein, adipocyte/0.451
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.451
3ibdCPZCytochrome P450 2B61.14.130.451
3iqhTYR_ASP_ILECysteine synthase2.5.1.470.451
3l63CAMCamphor 5-monooxygenase1.14.15.10.451
3oeyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
3otwCOAPhosphopantetheine adenylyltransferase/0.451
3toxNAPPutative oxidoreductase/0.451
4i6gFADCryptochrome-2/0.451
4ijp1EHSerine/threonine-protein kinase PRP4 homolog2.7.11.10.451
5a3cNADSIR2 family protein/0.451
1dirNADDihydropteridine reductase1.5.1.340.450
1i59ANPChemotaxis protein CheA2.7.13.30.450
2dfvNADL-threonine 3-dehydrogenase/0.450
2qboCAMCamphor 5-monooxygenase1.14.15.10.450
2wi72KLHeat shock protein HSP 90-alpha/0.450
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.450
3ndcSAHPrecorrin-4 C(11)-methyltransferase2.1.1.1330.450
3oibFDAPutative acyl-CoA dehydrogenase/0.450
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.450
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.450
3to6LYS_CMCHistone acetyltransferase ESA1/0.450
4btjADPTau-tubulin kinase 12.7.11.10.450
4nmdFDABifunctional protein PutA/0.450
4qmySTUSerine/threonine-protein kinase 242.7.11.10.450
1b2lNDCAlcohol dehydrogenase1.1.1.10.449
1msmJE2Gag-Pol polyprotein3.4.23.160.449
1nboNADGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic1.2.1.130.449
1qy5NECEndoplasmin/0.449
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.449
2ft9CHDFatty acid-binding protein 2, liver/0.449
2gv8NDPThiol-specific monooxygenase1.14.130.449
2q85973UDP-N-acetylenolpyruvoylglucosamine reductase1.3.1.980.449
2qiqCYVReplicase polyprotein 1ab/0.449
2qnqQN3Gag-Pol polyprotein3.4.23.160.449
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.449
2y8qADP5'-AMP-activated protein kinase subunit gamma-1/0.449
2znpK55Peroxisome proliferator-activated receptor delta/0.449
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.449
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.449
3ndvAICBeta-peptidyl aminopeptidase BapA/0.449
3p82FMNPentaerythritol tetranitrate reductase/0.449
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.449
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.449
4c2xNHWGlycylpeptide N-tetradecanoyltransferase 2/0.449
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.449
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.449
4h3ySAHtRNA (guanine-N(1)-)-methyltransferase/0.449
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.449
1c6yMK1Protease/0.448
1dz8CAMCamphor 5-monooxygenase1.14.15.10.448
1g1aNADdTDP-glucose 4,6-dehydratase/0.448
1jkx138Phosphoribosylglycinamide formyltransferase/0.448
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.448
1nzdUPGDNA beta-glucosyltransferase/0.448
1u5rATPSerine/threonine-protein kinase TAO22.7.11.10.448
2dvlFADAcyl-CoA dehydrogenase/0.448
2fy4COACholine O-acetyltransferase2.3.1.60.448
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.448
2m56CAMCamphor 5-monooxygenase1.14.15.10.448
3bg7FADPyranose 2-oxidase/0.448
3ey9TDPPyruvate dehydrogenase [ubiquinone]1.2.5.10.448
3f63GTXGlutathione transferase GST1-4/0.448
3ixp834Ecdysone receptor/0.448
3r374CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.448
3zpuM8BGag-Pol polyprotein3.4.23.160.448
3zs7ATPPyridoxine/pyridoxal/pyridoxamine kinase/0.448
4hmsFMNPhenazine biosynthesis protein PhzG1.40.448
4l4eCAMCamphor 5-monooxygenase1.14.15.10.448
6cp4CAMCamphor 5-monooxygenase1.14.15.10.448
1bk0ACVIsopenicillin N synthase1.21.3.10.447
1dhiMTXDihydrofolate reductase1.5.1.30.447
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.447
1mj9COAHistone acetyltransferase ESA1/0.447
2a92NAIL-lactate dehydrogenase/0.447
2abbFMNPentaerythritol tetranitrate reductase/0.447
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
2h96893Mitogen-activated protein kinase 82.7.11.240.447
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.447
2uxpCLMHTH-type transcriptional regulator TtgR/0.447
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.447
3d84NDPDihydrofolate reductase1.5.1.30.447
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
3h3cP1EProtein-tyrosine kinase 2-beta2.7.10.20.447
3h3r14HCollagen type IV alpha-3-binding protein/0.447
3ig6438Urokinase-type plasminogen activator3.4.21.730.447
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.447
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.447
4dc1NDPPutative ketoacyl reductase1.3.10.447
4l4cCAMCamphor 5-monooxygenase1.14.15.10.447
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.447
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.447
4m6jNDPDihydrofolate reductase1.5.1.30.447
4ocvANPAminoglycoside phosphotransferase/0.447
4px9ADPATP-dependent RNA helicase DDX3X3.6.4.130.447
4r21STRCytochrome P450 family 17 polypeptide 2/0.447
4yqfGDPSeptin-9/0.447
5cwa0GAAnthranilate synthase component 14.1.3.270.447
1aj8COACitrate synthase/0.446
1h74ADPHomoserine kinase2.7.1.390.446
1o9bNAIQuinate/shikimate dehydrogenase/0.446
1v9aSAHUncharacterized protein/0.446
2a7r5GPGMP reductase 2/0.446
2af3COAPhosphate acetyltransferase2.3.1.80.446
2bpw1INGag-Pol polyprotein3.4.23.160.446
2g1o2IGRenin3.4.23.150.446
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.446
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.446
2o23NAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.446
2qbuSAHPrecorrin-2 methyltransferase/0.446
2zuiCAMCamphor 5-monooxygenase1.14.15.10.446
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.446
3ggu017Gag-Pol polyprotein3.4.23.160.446
3h4lANPDNA mismatch repair protein PMS1/0.446
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.446
3litE15Protease/0.446
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.446
3ohh3HHBeta-secretase 13.4.23.460.446
3tnlNADShikimate dehydrogenase (NADP(+))/0.446
3ukoNADAlcohol dehydrogenase class-3/0.446
3vfa031Gag-Pol polyprotein3.4.23.160.446
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.446
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.446
4gavFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.446
4tqgNDPPutative dTDP-d-glucose 4 6-dehydratase/0.446
4xnw2IDP2Y purinoceptor 1/0.446
1bil0IURenin3.4.23.150.445
1dz6CAMCamphor 5-monooxygenase1.14.15.10.445
1m2qMNXCasein kinase II subunit alpha2.7.11.10.445
1phgMYTCamphor 5-monooxygenase1.14.15.10.445
1txtCAAHMG-CoA synthase/0.445
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.445
2b4tAESGlyceraldehyde-3-phosphate dehydrogenase/0.445
2b7aIZATyrosine-protein kinase JAK2/0.445
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.445
2g1r3IGRenin3.4.23.150.445
2ikuLIYRenin3.4.23.150.445
2iyfERYOleandomycin glycosyltransferase2.4.10.445
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.445
2ok7FADFerredoxin--NADP reductase, apicoplast/0.445
2q3rFMN12-oxophytodienoate reductase 11.3.1.420.445
2vbdV10Isopenicillin N synthase1.21.3.10.445
2wq6FADRE11660p/0.445
3bgbLJGGag-Pol polyprotein3.4.23.160.445
3el51UNGag-Pol polyprotein/0.445
3hx4ANPCalmodulin-domain protein kinase 1/0.445
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.445
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.445
3t2kFADSulfide-quinone reductase/0.445
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.445
4g95OAGDihydrofolate reductase1.5.1.30.445
4jx1CAHCamphor 5-monooxygenase1.14.15.10.445
4ktkKTKCytochrome P450/0.445
4l4fCAMCamphor 5-monooxygenase1.14.15.10.445
4p63NADProbable deoxyhypusine synthase2.5.1.460.445
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
5itzLOCTubulin beta-2B chain/0.445
1b8uNADMalate dehydrogenase/0.444
1bsvNDPGDP-L-fucose synthase/0.444
1civNAPMalate dehydrogenase [NADP], chloroplastic1.1.1.820.444
1e3eNAIAlcohol dehydrogenase 41.1.1.10.444
1rm4NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic1.2.1.130.444
1t86CAMCamphor 5-monooxygenase1.14.15.10.444
1u3dFADCryptochrome-1/0.444
2d8aNADL-threonine 3-dehydrogenase/0.444
2hfuMEVMevalonate kinase/0.444
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.444
2lbaCHOFatty acid binding protein 6/0.444
2nliFMNLactate oxidase/0.444
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.444
2rlcCHDCholoylglycine hydrolase3.5.1.240.444
2v7a627Tyrosine-protein kinase ABL12.7.10.20.444
2vkeTACTetracycline repressor protein class D/0.444
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.444
2xszATPRuvB-like 23.6.4.120.444
3b70NAPEnoyl reductase LovC10.444
3eteNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.444
3h3qH13Collagen type IV alpha-3-binding protein/0.444
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.444
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.444
3ijoB4DGlutamate receptor 2/0.444
3imeBZ2Pantothenate synthetase6.3.2.10.444
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.444
3pw8ACO1,2-phenylacetyl-CoA epoxidase, subunit A1.14.13.1490.444
3sz0FADSulfide-quinone reductase/0.444
3t3r9PLCytochrome P450 2A61.14.130.444
3wbbNAPMeso-diaminopimelate D-dehydrogenase/0.444
3zoiM2WIsopenicillin N synthase1.21.3.10.444
4a6nFADTetX family tetracycline inactivation enzyme/0.444
4bfxZVXPantothenate kinase2.7.1.330.444
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
4df2FMNNADPH dehydrogenase/0.444
4ek1CAMCamphor 5-monooxygenase1.14.15.10.444
4eywL0RCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.444
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.444
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.444
4zowCLMMultidrug transporter MdfA/0.444
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
5cvhADPCasein kinase II subunit alpha2.7.11.10.444
4djhJDCKappa-type opioid receptor/0.444
1dyhDZFDihydrofolate reductase1.5.1.30.443
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
1gcoNADGlucose 1-dehydrogenase1.1.1.470.443
1icpFMN12-oxophytodienoate reductase 11.3.1.420.443
1mjaCOAHistone acetyltransferase ESA1/0.443
1t2cNAIL-lactate dehydrogenase1.1.1.270.443
1tezFADDeoxyribodipyrimidine photo-lyase4.1.99.30.443
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.443
1y0s331Peroxisome proliferator-activated receptor delta/0.443
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
2drcMTXDihydrofolate reductase1.5.1.30.443
2e9dB76Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.443
2qtvGNPSmall COPII coat GTPase SAR13.6.50.443
2y9qANPMitogen-activated protein kinase 12.7.11.240.443
3b6zCO7Enoyl reductase LovC10.443
3gggNADPrephenate dehydrogenase/0.443
3gobHXXDdmC/0.443
3lshFADPyranose 2-oxidase/0.443
3ox4NADAlcohol dehydrogenase 21.1.1.10.443
3pvrBYC1,2-phenylacetyl-CoA epoxidase, subunit A1.14.13.1490.443
3s87ADPRibonucleoside-diphosphate reductase large chain 11.17.4.10.443
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.443
3wv9FEGHmd co-occurring protein HcgE/0.443
4a2zMYAGlycylpeptide N-tetradecanoyltransferase/0.443
4a6cQG9Gag-Pol polyprotein3.4.23.160.443
4b10NHWGlycylpeptide N-tetradecanoyltransferase/0.443
4b14NHWGlycylpeptide N-tetradecanoyltransferase/0.443
4ew2DXYTrifunctional purine biosynthetic protein adenosine-32.1.2.20.443
4nbwNADShort-chain dehydrogenase/reductase SDR/0.443
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.443
1c9k5GPBifunctional adenosylcobalamin biosynthesis protein CobU/0.442
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1dz4CAMCamphor 5-monooxygenase1.14.15.10.442
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.442
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.442
1ipeNDPTropinone reductase 21.1.1.2360.442
1l3iSAHProbable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)/0.442
1me6IVSPlasmepsin-23.4.23.390.442
1obbNADAlpha-glucosidase3.2.1.200.442
1p0hACOMycothiol acetyltransferase2.3.1.1890.442
1rd7FOLDihydrofolate reductase1.5.1.30.442
1rf7DHFDihydrofolate reductase1.5.1.30.442
1s5kCOAAminoglycoside N(6')-acetyltransferase type 1/0.442
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.442
1vi2NADQuinate/shikimate dehydrogenase/0.442
1zgyBRLPeroxisome proliferator-activated receptor gamma/0.442
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.442
2b36NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2feuCAMCamphor 5-monooxygenase1.14.15.10.442
2givACOHistone acetyltransferase KAT8/0.442
2iqgF2IBeta-secretase 13.4.23.460.442
2jkkBI9Focal adhesion kinase 12.7.10.20.442
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.442
2y60M8FIsopenicillin N synthase1.21.3.10.442
3cgfJNFMitogen-activated protein kinase 102.7.11.240.442
3cgoJNOMitogen-activated protein kinase 102.7.11.240.442
3h3sH15Collagen type IV alpha-3-binding protein/0.442
3iodA6DPantothenate synthetase6.3.2.10.442
3nxxNDPDihydrofolate reductase1.5.1.30.442
3pvt3HC1,2-phenylacetyl-CoA epoxidase, subunit A1.14.13.1490.442
3rpeFADPutative modulator of drug activity/0.442
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
3sopGDPNeuronal-specific septin-3/0.442
3ttjJBIMitogen-activated protein kinase 102.7.11.240.442
4a33MYAGlycylpeptide N-tetradecanoyltransferase/0.442
4bqjXKLHeat shock protein HSP 90-alpha/0.442
4cdmFADDeoxyribodipyrimidine photolyase/0.442
4gdcNDPUDP-galactopyranose mutase/0.442
4jnkNAIL-lactate dehydrogenase A chain1.1.1.270.442
5c77SAHProtein arginine N-methyltransferase SFM1/0.442
5cyoGDPSeptin-9/0.442
1egeFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.441
1fm4DXCMajor pollen allergen Bet v 1-L/0.441
1h74AGSHomoserine kinase2.7.1.390.441
1rj6AZMCarbonic anhydrase 144.2.1.10.441
1rwbNADGlucose 1-dehydrogenase1.1.1.470.441
1tj0FADBifunctional protein PutA1.5.5.20.441
1zmdNAIDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.441
2c12FADNitroalkane oxidase1.7.3.10.441
2g1s4IGRenin3.4.23.150.441
2ibzUQ6Cytochrome b/0.441
2idzZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
2rhgIGPTryptophan synthase alpha chain/0.441
2y3rTRKTamL/0.441
2yxuATPPyridoxal kinase2.7.1.350.441
2zb3NDPProstaglandin reductase 21.3.1.480.441
3a3yOBNSodium/potassium-transporting ATPase subunit alpha/0.441
3eljGS7Mitogen-activated protein kinase 82.7.11.240.441
3h8bNSYCathepsin L13.4.22.150.441
3k4nFADPyranose 2-oxidase/0.441
3l0lHC3Nuclear receptor ROR-gamma/0.441
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.441
3mdmFJZCholesterol 24-hydroxylase/0.441
3pe6ZYHMonoglyceride lipase/0.441
3pm1ETHTH-type transcriptional regulator QacR/0.441
3r7eX88Cyclin-dependent kinase 22.7.11.220.441
3vswR31Renin3.4.23.150.441
3wrlCAMCamphor 5-monooxygenase1.14.15.10.441
4bgg844Activin receptor type-12.7.11.300.441
4bj9UHBTankyrase-22.4.2.300.441
4dpy2P0Mevalonate diphosphate decarboxylase/0.441
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.441
4gl4NAIAlcohol dehydrogenase class-3/0.441
4iaxLIZNeutrophil gelatinase-associated lipocalin/0.441
4jx1CAMCamphor 5-monooxygenase1.14.15.10.441
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.441
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
1bdmNAXMalate dehydrogenase/0.440
1nzfUPGDNA beta-glucosyltransferase/0.440
1o0sNAINAD-dependent malic enzyme, mitochondrial1.1.1.380.440
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
1sxjAGSReplication factor C subunit 1/0.440
1u1f183Uridine phosphorylase2.4.2.30.440
1u4dDBQActivated CDC42 kinase 1/0.440
1wzeNADMalate dehydrogenase/0.440
1ywgNADGlyceraldehyde-3-phosphate dehydrogenase/0.440
1zrqFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.440
2dbvNDPGlyceraldehyde-3-phosphate dehydrogenase/0.440
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.440
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.440
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.440
2ghlLIBMitogen-activated protein kinase 14/0.440
2p20PRXAcetyl-coenzyme A synthetase/0.440
2pwlACPFibroblast growth factor receptor 2/0.440
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.440
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.440
3hgoFMN12-oxophytodienoate reductase 31.3.1.420.440
3kxw1ZZSaframycin Mx1 synthetase B/0.440
3ogqAB1Pol polyprotein/0.440
3orfNADDihydropteridine reductase1.5.1.340.440
3p8iFMNPentaerythritol tetranitrate reductase/0.440
3t4nADP5'-AMP-activated protein kinase subunit gamma/0.440
3w2nRODDihydroorotate dehydrogenase (fumarate)1.3.98.10.440
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.440
4cztCPSCBL-interacting serine/threonine-protein kinase 232.7.11.10.440
4ejvLCLTranscriptional regulator TcaR/0.440
4er6AW2Histone-lysine N-methyltransferase, H3 lysine-79 specific2.1.1.430.440
4esoNAPPutative oxidoreductase/0.440
4ips1G4Mycocyclosin synthase1.14.21.90.440
4jb1FADUDP-N-acetylenolpyruvoylglucosamine reductase/0.440
4qi5FADCellobiose dehydrogenase/0.440
4xwtU5PRibonuclease J/0.440