sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4pry | LEU_GLU_THR_ACE_ASA | Caspase-3 | 3.4.22.56 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4pry | LEU_GLU_THR_ACE_ASA | Caspase-3 | 3.4.22.56 | 1.000 | |
| 1nmq | 160 | Caspase-3 | 3.4.22.56 | 0.603 | |
| 4zvr | ASP_GLU_VAL_ACE_ASJ | Caspase-7 | 3.4.22.60 | 0.543 | |
| 4dyn | 0MR | Nucleoprotein | / | 0.509 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.498 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.497 | |
| 3f8s | PF2 | Dipeptidyl peptidase 4 | / | 0.497 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.496 | |
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.496 | |
| 4b2g | V1N | Uncharacterized protein | / | 0.492 | |
| 4zvp | ASP_GLU_VAL_ACE_ASA | Caspase-7 | 3.4.22.60 | 0.491 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.490 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.490 | |
| 3ele | PLP | Aminotransferase | / | 0.489 | |
| 3hdy | GDU | UDP-galactopyranose mutase | / | 0.489 | |
| 3lnc | 5GP | Guanylate kinase | / | 0.489 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.487 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.486 | |
| 3udj | 092 | Beta-secretase 1 | 3.4.23.46 | 0.486 | |
| 4i1c | 1BE | Beta-secretase 1 | 3.4.23.46 | 0.486 | |
| 5bnw | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.486 | |
| 3c6p | 2S3 | Protein TRANSPORT INHIBITOR RESPONSE 1 | / | 0.485 | |
| 4k88 | HFG | Bifunctional glutamate/proline--tRNA ligase | 6.1.1.15 | 0.485 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.483 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.483 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.483 | |
| 3pkd | Y10 | Methionine aminopeptidase 2 | / | 0.483 | |
| 3ccc | 7AC | Dipeptidyl peptidase 4 | / | 0.482 | |
| 3gf4 | UPG | UDP-galactopyranose mutase | 5.4.99.9 | 0.482 | |
| 4pzs | ACO | Histone acetyltransferase p300 | / | 0.482 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.481 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.480 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.480 | |
| 4j4n | D44 | Peptidylprolyl isomerase | / | 0.480 | |
| 1o01 | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.479 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.479 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.479 | |
| 3vjk | M51 | Dipeptidyl peptidase 4 | / | 0.479 | |
| 4flj | Y08 | Methionine aminopeptidase 1 | / | 0.479 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.478 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.478 | |
| 2an9 | GDP | Guanylate kinase | 2.7.4.8 | 0.478 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.478 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.478 | |
| 4fli | Y16 | Methionine aminopeptidase 1 | / | 0.478 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.478 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.478 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.477 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.477 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.476 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.476 | |
| 4h9t | HL4 | Phosphotriesterase | / | 0.476 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.475 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.475 | |
| 2zrx | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.475 | |
| 2zts | ADP | Uncharacterized protein | / | 0.475 | |
| 4b67 | NAP | L-ornithine N(5)-monooxygenase | / | 0.475 | |
| 1oz0 | MS1 | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.474 | |
| 3ccb | B2Y | Dipeptidyl peptidase 4 | / | 0.474 | |
| 4k36 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.474 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.474 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.473 | |
| 2xyd | 3ES | Angiotensin-converting enzyme | 3.2.1 | 0.473 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.473 | |
| 4j0z | 1H5 | Beta-secretase 1 | 3.4.23.46 | 0.473 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.472 | |
| 4fll | YZ6 | Methionine aminopeptidase 1 | / | 0.472 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.471 | |
| 2xq0 | BES | Leukotriene A-4 hydrolase homolog | 3.3.2.6 | 0.471 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.471 | |
| 4i10 | 1BS | Beta-secretase 1 | 3.4.23.46 | 0.471 | |
| 1og4 | NAI | T-cell ecto-ADP-ribosyltransferase 2 | / | 0.470 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.470 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.470 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.470 | |
| 4b64 | NAP | L-ornithine N(5)-monooxygenase | / | 0.470 | |
| 4ifn | 12O | Kelch-like ECH-associated protein 1 | / | 0.470 | |
| 1x2b | STX | Proline iminopeptidase | 3.4.11.5 | 0.469 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.469 | |
| 2zru | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.469 | |
| 3mj4 | URM | UDP-galactopyranose mutase | / | 0.469 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.469 | |
| 4k39 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.469 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.468 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.468 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.468 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.468 | |
| 3hdq | GDU | UDP-galactopyranose mutase | / | 0.468 | |
| 3juo | AJD | Phenazine biosynthesis protein A/B | / | 0.468 | |
| 3q8u | ADP | Nucleoside diphosphate kinase | / | 0.468 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 4flk | Y10 | Methionine aminopeptidase 1 | / | 0.468 | |
| 4gv8 | DUP | DUTPase | / | 0.468 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.467 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.467 | |
| 2ixk | TDO | dTDP-4-dehydrorhamnose 3,5-epimerase | 5.1.3.13 | 0.467 | |
| 2pj4 | 414 | Carboxypeptidase B | / | 0.467 | |
| 2rd2 | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.467 | |
| 3g0b | T22 | Dipeptidyl peptidase 4 | / | 0.467 | |
| 4f5d | C2E | Stimulator of interferon genes protein | / | 0.467 | |
| 4rpg | GDU | UDP-galactopyranose mutase | 5.4.99.9 | 0.467 | |
| 1pwy | AC2 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.466 | |
| 2aj8 | SC3 | Dipeptidyl peptidase 4 | / | 0.466 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.466 | |
| 2wwj | Y28 | Lysine-specific demethylase 4A | / | 0.466 | |
| 3abx | RCB | Glucanase | / | 0.466 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.466 | |
| 3r7n | ASP_VAL_ALA_ACE_ASA | Caspase-2 | 3.4.22.55 | 0.466 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 3vjl | W94 | Dipeptidyl peptidase 4 | / | 0.466 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.466 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 1kh3 | ANP | Argininosuccinate synthase | / | 0.465 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.465 | |
| 2zrz | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.465 | |
| 4bek | XK0 | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 4ohw | ATP | Protein clpf-1 | / | 0.465 | |
| 4qak | 2AM | RNA 2',3'-cyclic phosphodiesterase | / | 0.465 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 1nhk | CMP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.464 | |
| 2oz5 | 7XY | Uncharacterized protein | / | 0.464 | |
| 3g0c | RUF | Dipeptidyl peptidase 4 | / | 0.464 | |
| 4wlj | IK2 | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.464 | |
| 4yp1 | 2BA | Stimulator of interferon genes protein | / | 0.464 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.463 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.463 | |
| 1xry | BES | Bacterial leucyl aminopeptidase | 3.4.11.10 | 0.463 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.463 | |
| 2xiq | 5AD | Methylmalonyl-CoA mutase, mitochondrial | / | 0.463 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 3fr4 | F8A | Fatty acid-binding protein, adipocyte | / | 0.463 | |
| 3lm1 | LEC | Agglutinin alpha chain | / | 0.463 | |
| 3rth | RTH | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.463 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.462 | |
| 1ni1 | 2C5 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.462 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 2h21 | SAM | Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic | 2.1.1.127 | 0.462 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.462 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 4hmv | WUB | Phenazine biosynthesis protein PhzG | 1.4 | 0.462 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.462 | |
| 1je1 | GMP | Purine nucleoside phosphorylase | / | 0.461 | |
| 2idv | M7G | Eukaryotic translation initiation factor 4E-1 | / | 0.461 | |
| 2q93 | B21 | Methionine aminopeptidase | / | 0.461 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.461 | |
| 4bfd | 8T3 | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.461 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.461 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.461 | |
| 4yfy | 0FX | VioF | / | 0.461 | |
| 1be4 | PCG | Nucleoside diphosphate kinase A 2 | 2.7.4.6 | 0.460 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 2xnv | VU3 | Soluble acetylcholine receptor | / | 0.460 | |
| 4aws | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.460 | |
| 4qfy | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.460 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.459 | |
| 2bn4 | FMN | NADPH--cytochrome P450 reductase | / | 0.459 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.459 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.459 | |
| 2iu8 | UD1 | UDP-3-O-acylglucosamine N-acyltransferase | 2.3.1 | 0.459 | |
| 2p99 | YE6 | Methionine aminopeptidase | / | 0.459 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.459 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.459 | |
| 3ebl | GA4 | Gibberellin receptor GID1 | / | 0.459 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.459 | |
| 4acu | QN7 | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 4to2 | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.459 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.458 | |
| 2q96 | A18 | Methionine aminopeptidase | / | 0.458 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.458 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.458 | |
| 3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.458 | |
| 3kyb | FMN | UDP-galactopyranose mutase | 5.4.99.9 | 0.458 | |
| 4b66 | FAD | L-ornithine N(5)-monooxygenase | / | 0.458 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.458 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.458 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 2evc | FC3 | Methionine aminopeptidase | / | 0.457 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.457 | |
| 2w02 | ATP | AcsD | / | 0.457 | |
| 2x3j | ATP | AcsD | / | 0.457 | |
| 3g0g | RUM | Dipeptidyl peptidase 4 | / | 0.457 | |
| 3pz4 | 3PZ | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.457 | |
| 3skg | PB8 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4a5s | N7F | Dipeptidyl peptidase 4 | / | 0.457 | |
| 1ds7 | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.456 | |
| 1ni1 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.456 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 2hwu | URI | Uridine phosphorylase | 2.4.2.3 | 0.456 | |
| 2va7 | C27 | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 3isi | B88 | Putative dipeptidase | / | 0.456 | |
| 3pn1 | IVH | DNA ligase | / | 0.456 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.456 | |
| 4d6q | PD2 | Lysine-specific demethylase 4D | 1.14.11 | 0.456 | |
| 4l0o | PLP | Cystathionine gamma-synthase | 2.5.1.48 | 0.456 | |
| 4lut | DCS | Alanine racemase | / | 0.456 | |
| 4rvf | TYD | D-mycarose 3-C-methyltransferase | / | 0.456 | |
| 1n2g | APC | Pantothenate synthetase | 6.3.2.1 | 0.455 | |
| 2gg0 | U11 | Methionine aminopeptidase | / | 0.455 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.455 | |
| 2pak | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.455 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.455 | |
| 3mvz | BHN | Nickel-binding periplasmic protein | / | 0.455 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.455 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 4eil | UMP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
| 4j0t | 6T9 | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 4ohf | 5GP | Cytosolic IMP-GMP specific 5'-nucleotidase | / | 0.455 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.454 | |
| 2aba | STR | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.454 | |
| 3inr | GDU | UDP-galactopyranose mutase | 5.4.99.9 | 0.454 | |
| 3mj4 | FAD | UDP-galactopyranose mutase | / | 0.454 | |
| 3opm | LUI | Dipeptidyl peptidase 4 | / | 0.454 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.454 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.454 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 4dyb | 0MH | Nucleoprotein | / | 0.454 | |
| 4lrr | CF9 | Thymidylate synthase | / | 0.454 | |
| 4uy6 | SAH | Histidine N-alpha-methyltransferase | / | 0.454 | |
| 1zzu | DP1 | Nitric oxide synthase, brain | 1.14.13.39 | 0.453 | |
| 2gms | P0P | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.453 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
| 3zvm | ADP | Bifunctional polynucleotide phosphatase/kinase | 2.7.1.78 | 0.453 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.453 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.453 | |
| 4in4 | 4ID | Kelch-like ECH-associated protein 1 | / | 0.453 | |
| 4jay | NAP | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.453 | |
| 1lv8 | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.452 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.452 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.452 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.452 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.452 | |
| 2h63 | NAP | Biliverdin reductase A | 1.3.1.24 | 0.452 | |
| 2r8p | T6F | Transketolase 1 | / | 0.452 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 3cb2 | GDP | Tubulin gamma-1 chain | / | 0.452 | |
| 3pkc | Y08 | Methionine aminopeptidase 2 | / | 0.452 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.452 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.452 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.452 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.452 | |
| 4rhe | FMN | Flavin prenyltransferase UbiX | / | 0.452 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.451 | |
| 2evm | FC2 | Methionine aminopeptidase | / | 0.451 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.451 | |
| 3b4p | 3B4 | Phenazine biosynthesis protein A/B | / | 0.451 | |
| 3dt2 | GTP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.451 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.451 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.451 | |
| 3kmy | D8Y | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3n76 | CA2 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.451 | |
| 4nv1 | 4TG | Formyl transferase | / | 0.451 | |
| 1amo | FMN | NADPH--cytochrome P450 reductase | / | 0.450 | |
| 1an5 | CB3 | Thymidylate synthase | / | 0.450 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.450 | |
| 1i7m | CG | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.450 | |
| 1lc3 | NAD | Biliverdin reductase A | 1.3.1.24 | 0.450 | |
| 1qrt | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.450 | |
| 1w76 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.450 | |
| 2vd7 | PD2 | Lysine-specific demethylase 4A | 1.14.11 | 0.450 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 3akm | 11D | Fatty acid-binding protein, intestinal | / | 0.450 | |
| 3ojx | FAD | NADPH--cytochrome P450 reductase | / | 0.450 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.450 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.450 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4bzb | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.450 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.450 | |
| 1a7x | FKA | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.449 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1ozv | SAH | Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic | 2.1.1.127 | 0.449 | |
| 1w19 | T1P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.449 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.449 | |
| 2fxf | ACO | Diamine acetyltransferase 1 | / | 0.449 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.449 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 3nt2 | NAD | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.449 | |
| 3wb4 | 0B3 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4lxl | PD2 | Lysine-specific demethylase 4B | 1.14.11 | 0.449 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.449 | |
| 4qfz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.449 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.448 | |
| 1gtr | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.448 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 1qtq | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.448 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.448 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.448 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2re8 | GSU | Glutamine--tRNA ligase | 6.1.1.18 | 0.448 | |
| 2wzw | NDP | Nitroreductase NfnB | / | 0.448 | |
| 3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 3l3m | A92 | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.448 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 4a6n | T1C | TetX family tetracycline inactivation enzyme | / | 0.448 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.448 | |
| 4q7f | 3D1 | Uncharacterized protein | / | 0.448 | |
| 5bv3 | M7G | m7GpppX diphosphatase | 3.6.1.59 | 0.448 | |
| 5c80 | URI | Uridine phosphorylase | / | 0.448 | |
| 1ld7 | U66 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.447 | |
| 2q92 | B23 | Methionine aminopeptidase | / | 0.447 | |
| 2qjo | NAD | Bifunctional NMN adenylyltransferase/Nudix hydrolase | 2.7.7.1 | 0.447 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.447 | |
| 2tpl | HPP | Tyrosine phenol-lyase | 4.1.99.2 | 0.447 | |
| 2x90 | EAL | Angiotensin-converting enzyme | 3.4.15.1 | 0.447 | |
| 2xda | JPS | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.447 | |
| 2zrv | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.447 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.447 | |
| 3w0t | HPU | Lactoylglutathione lyase | 4.4.1.5 | 0.447 | |
| 4dan | 2FA | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.447 | |
| 4fl0 | PLP | Aminotransferase ALD1, chloroplastic | 2.6.1 | 0.447 | |
| 4to1 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.447 | |
| 5cho | FAD | Flavin reductase | / | 0.447 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1if6 | FBU | Carbonic anhydrase 2 | 4.2.1.1 | 0.446 | |
| 1pua | COA | HAT A1 | / | 0.446 | |
| 1wkl | ATP | Nucleoside diphosphate kinase | / | 0.446 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2c6c | 24I | Glutamate carboxypeptidase 2 | 3.4.17.21 | 0.446 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.446 | |
| 2q94 | A04 | Methionine aminopeptidase | / | 0.446 | |
| 2rgu | 356 | Dipeptidyl peptidase 4 | / | 0.446 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.446 | |
| 3h0b | B35 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.446 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.446 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.446 | |
| 4fs4 | H24 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4j7g | TRH | PCZA361.3 | / | 0.446 | |
| 4rph | GDU | UDP-galactopyranose mutase | 5.4.99.9 | 0.446 | |
| 4z87 | GDP | Inosine-5'-monophosphate dehydrogenase | / | 0.446 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.446 | |
| 1gvh | FAD | Flavohemoprotein | / | 0.445 | |
| 1nj5 | P5A | Proline--tRNA ligase | / | 0.445 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.445 | |
| 1vhn | FMN | tRNA-dihydrouridine synthase | / | 0.445 | |
| 2xb8 | XNW | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.445 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.445 | |
| 3h2s | NDP | Putative NADH-flavin reductase | / | 0.445 | |
| 3kkz | SAM | Uncharacterized protein | / | 0.445 | |
| 3q7j | FBO | Tricorn protease-interacting factor F3 | 3.4.11 | 0.445 | |
| 3v2u | ATP | Protein GAL3 | / | 0.445 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.445 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4kw5 | 1W6 | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.445 | |
| 4yal | 2AM | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 1fkf | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.444 | |
| 1fki | SB1 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.444 | |
| 1i91 | INQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 1j37 | X8Z | Angiotensin-converting enzyme | 3.4.15.1 | 0.444 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 1s64 | 778 | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.444 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.444 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.444 | |
| 2h15 | B19 | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2xvh | NAP | Putative flavin-containing monooxygenase | / | 0.444 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 3rl3 | 5GP | Metallophosphoesterase MPPED2 | 3.1 | 0.444 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.444 | |
| 4ikz | AFS | Di-tripeptide ABC transporter (Permease) | / | 0.444 | |
| 4to4 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.444 | |
| 4zwe | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.444 | |
| 5d7p | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.444 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.443 | |
| 1k4m | NAD | Nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.443 | |
| 1kw6 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.443 | |
| 1yki | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.443 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.443 | |
| 2q0g | UPU | Poly(A) polymerase, putative | / | 0.443 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.443 | |
| 2x91 | LPR | Angiotensin-converting enzyme | 3.4.15.1 | 0.443 | |
| 2xys | SY9 | Soluble acetylcholine receptor | / | 0.443 | |
| 3e30 | ED4 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 3g6z | A7T | Renin | 3.4.23.15 | 0.443 | |
| 3n19 | FNR | Xenobiotic reductase | / | 0.443 | |
| 4c13 | UML | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | / | 0.443 | |
| 4clo | NAP | Pteridine reductase | / | 0.443 | |
| 4yaw | 2AM | NADPH--cytochrome P450 reductase | / | 0.443 | |
| 5jj0 | SAM | Histone-lysine N-methyltransferase EHMT2 | / | 0.443 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1qrs | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.442 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.442 | |
| 1v5y | 4HC | Major NAD(P)H-flavin oxidoreductase | 1.6.99 | 0.442 | |
| 2rfi | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.442 | |
| 2vet | UMP | Thymidylate synthase | / | 0.442 | |
| 3d27 | W29 | Methionine aminopeptidase | / | 0.442 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3qbj | NXZ | Dipeptidyl peptidase 4 | / | 0.442 | |
| 3rfa | SAM | Dual-specificity RNA methyltransferase RlmN | / | 0.442 | |
| 3uth | GDU | UDP-galactopyranose mutase | / | 0.442 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 4h6p | FMN | Chromate reductase | / | 0.442 | |
| 4hhy | 15R | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.442 | |
| 4to5 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.442 | |
| 4xnh | ACO | N-terminal acetyltransferase A complex subunit NAT5 | 2.3.1 | 0.442 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.442 | |
| 5d7q | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.442 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.441 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.441 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.441 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1ikg | REX | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.441 | |
| 1tu8 | GTX | Glutathione S-transferase 2 | 2.5.1.18 | 0.441 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2xlu | NA7 | Putative flavin-containing monooxygenase | / | 0.441 | |
| 3fx4 | FX4 | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.441 | |
| 3hii | PNT | Amiloride-sensitive amine oxidase [copper-containing] | / | 0.441 | |
| 3mes | PT3 | Putative choline kinase | / | 0.441 | |
| 3ukf | GDU | UDP-galactopyranose mutase | / | 0.441 | |
| 3vkj | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.441 | |
| 4awt | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.441 | |
| 4b1c | 1B1 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4k37 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.441 | |
| 4kl1 | PCG | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | / | 0.441 | |
| 4l7h | 1W1 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4lzw | THM | Uridine phosphorylase | / | 0.441 | |
| 4rp8 | ASC | Ascorbate-specific PTS system EIIC component | / | 0.441 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.441 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.441 | |
| 4xr9 | NAD | CalS8 | / | 0.441 | |
| 1pr4 | MTP | Purine nucleoside phosphorylase DeoD-type | / | 0.440 | |
| 2gg9 | U16 | Methionine aminopeptidase | / | 0.440 | |
| 2h8x | FMN | XenA | / | 0.440 | |
| 2hpv | FMN | FMN-dependent NADH-azoreductase | 1.7 | 0.440 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.440 | |
| 2o8j | SAH | Histone-lysine N-methyltransferase EHMT2 | / | 0.440 | |
| 3e4a | QIX | Insulin-degrading enzyme | 3.4.24.56 | 0.440 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.440 | |
| 3zho | FMN | NAD(P)H dehydrogenase (quinone) | / | 0.440 | |
| 4a16 | H34 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.440 | |
| 4gd4 | 0WS | Lysine-specific demethylase 4A | 1.14.11 | 0.440 | |
| 4lc7 | 1WP | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 5fmm | MGT | Polymerase basic protein 2 | / | 0.440 |