sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4i12 | 1BC | Beta-secretase 1 | 3.4.23.46 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4i12 | 1BC | Beta-secretase 1 | 3.4.23.46 | 1.000 | |
| 4i11 | 1CH | Beta-secretase 1 | 3.4.23.46 | 0.650 | |
| 2ohr | 8IP | Beta-secretase 1 | 3.4.23.46 | 0.585 | |
| 4i0z | 1BB | Beta-secretase 1 | 3.4.23.46 | 0.561 | |
| 4i1c | 1BE | Beta-secretase 1 | 3.4.23.46 | 0.557 | |
| 4i0f | 1BF | Beta-secretase 1 | 3.4.23.46 | 0.550 | |
| 2va6 | H24 | Beta-secretase 1 | 3.4.23.46 | 0.542 | |
| 2ohp | 6IP | Beta-secretase 1 | 3.4.23.46 | 0.538 | |
| 3bug | AEH | Beta-secretase 1 | 3.4.23.46 | 0.528 | |
| 4ha5 | 13W | Beta-secretase 1 | 3.4.23.46 | 0.528 | |
| 4j1k | 1HG | Beta-secretase 1 | 3.4.23.46 | 0.525 | |
| 2va7 | C27 | Beta-secretase 1 | 3.4.23.46 | 0.521 | |
| 4drm | 0MC | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.520 | |
| 2xnc | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.516 | |
| 4drp | 0MD | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.515 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.511 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.510 | |
| 3zmg | 6Z0 | Beta-secretase 1 | 3.4.23.46 | 0.508 | |
| 4j1c | 1HO | Beta-secretase 1 | 3.4.23.46 | 0.508 | |
| 4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.507 | |
| 4j17 | 1HQ | Beta-secretase 1 | 3.4.23.46 | 0.504 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.502 | |
| 1lke | DOG | Bilin-binding protein | / | 0.502 | |
| 2e8q | SAH | Diphthine synthase | / | 0.502 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.501 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.501 | |
| 4dro | 0MD | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.501 | |
| 1qgz | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.500 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.499 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.499 | |
| 2ek7 | SAH | Diphthine synthase | / | 0.499 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.499 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.498 | |
| 3rvi | RVI | Beta-secretase 1 | 3.4.23.46 | 0.498 | |
| 4bam | MM9 | Prothrombin | 3.4.21.5 | 0.496 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.495 | |
| 4j1e | 1HM | Beta-secretase 1 | 3.4.23.46 | 0.495 | |
| 4b67 | NAP | L-ornithine N(5)-monooxygenase | / | 0.494 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.494 | |
| 1gaw | FAD | Ferredoxin | / | 0.493 | |
| 1qh0 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.493 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.493 | |
| 4j0y | 1H6 | Beta-secretase 1 | 3.4.23.46 | 0.492 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.491 | |
| 2ohu | IP7 | Beta-secretase 1 | 3.4.23.46 | 0.491 | |
| 4jfi | 1KT | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.491 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.490 | |
| 2d1o | FA4 | Stromelysin-1 | 3.4.24.17 | 0.490 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.490 | |
| 4lay | I63 | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.490 | |
| 3biu | 10U | Prothrombin | 3.4.21.5 | 0.489 | |
| 3fpk | FAD | Ferredoxin-NADP reductase | / | 0.489 | |
| 3ho2 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.489 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.488 | |
| 2emr | SAH | Diphthine synthase | / | 0.487 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.487 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.487 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.486 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.486 | |
| 2reh | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.485 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.485 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.484 | |
| 2zg0 | 50U | Prothrombin | 3.4.21.5 | 0.484 | |
| 2zhq | 27U | Prothrombin | 3.4.21.5 | 0.484 | |
| 4f0e | 0RU | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.484 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.483 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.482 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.482 | |
| 2qiq | CYV | Replicase polyprotein 1ab | / | 0.482 | |
| 2v3h | I25 | Prothrombin | 3.4.21.5 | 0.482 | |
| 4drk | I63 | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.482 | |
| 1gjr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.481 | |
| 4hzt | 0ZA | Beta-secretase 1 | 3.4.23.46 | 0.481 | |
| 4rel | KMP | Glycosyltransferase | / | 0.481 | |
| 1vce | SAH | Diphthine synthase | / | 0.480 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.480 | |
| 2emu | SAH | Diphthine synthase | / | 0.480 | |
| 2zgb | 21U | Prothrombin | 3.4.21.5 | 0.480 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.480 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.480 | |
| 1c4v | IH2 | Prothrombin | 3.4.21.5 | 0.479 | |
| 1iki | REY | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.479 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.479 | |
| 2hux | SAH | Diphthine synthase | / | 0.479 | |
| 3c1o | NAP | Eugenol synthase | / | 0.479 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.479 | |
| 4y0k | NAP | AntE | / | 0.479 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.478 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.478 | |
| 1yqs | BSA | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.478 | |
| 2dv4 | SAH | Diphthine synthase | / | 0.478 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.478 | |
| 4b1c | 1B1 | Beta-secretase 1 | 3.4.23.46 | 0.478 | |
| 1fnb | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.477 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.477 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.477 | |
| 2en5 | SAH | Diphthine synthase | / | 0.477 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.477 | |
| 4fs4 | H24 | Beta-secretase 1 | 3.4.23.46 | 0.477 | |
| 4y7c | FMN | NADPH--cytochrome P450 reductase | / | 0.477 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.476 | |
| 2e07 | SAH | Diphthine synthase | / | 0.476 | |
| 2e1z | B4P | Propionate kinase | / | 0.476 | |
| 2fb3 | 5AD | GTP 3',8-cyclase | 4.1.99.18 | 0.476 | |
| 2zhf | 49U | Prothrombin | 3.4.21.5 | 0.476 | |
| 3myt | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.476 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.476 | |
| 2p6l | SAH | Diphthine synthase | / | 0.475 | |
| 3eks | CY9 | Actin-5C | / | 0.475 | |
| 4gtm | 7TM | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.475 | |
| 4jp9 | 1M5 | Beta-secretase 1 | 3.4.23.46 | 0.475 | |
| 1fkb | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.474 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.474 | |
| 1w87 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.474 | |
| 2anm | CDO | Prothrombin | 3.4.21.5 | 0.474 | |
| 2dv7 | SAH | Diphthine synthase | / | 0.474 | |
| 2ohj | FMN | Type A flavoprotein FprA | 1 | 0.474 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.474 | |
| 3zkn | WZV | Beta-secretase 2 | 3.4.23.45 | 0.474 | |
| 1bjk | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.473 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit alpha | 1.2.4.4 | 0.473 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit beta | 1.2.4.4 | 0.473 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.473 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.473 | |
| 4af7 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.473 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.473 | |
| 4lxm | 1YU | Beta-secretase 1 | 3.4.23.46 | 0.473 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.473 | |
| 1go2 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.472 | |
| 1t4u | 81A | Prothrombin | 3.4.21.5 | 0.472 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.472 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.472 | |
| 4c43 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.472 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.471 | |
| 1e62 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.471 | |
| 1w35 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.471 | |
| 2vr1 | ATF | Biotin carboxylase | 6.3.4.14 | 0.471 | |
| 2zgx | 29U | Prothrombin | 3.4.21.5 | 0.471 | |
| 4ise | 1FW | Glucokinase | 2.7.1.2 | 0.471 | |
| 1sb1 | 165 | Prothrombin | 3.4.21.5 | 0.470 | |
| 2pj4 | 414 | Carboxypeptidase B | / | 0.470 | |
| 2zdv | 37U | Prothrombin | 3.4.21.5 | 0.470 | |
| 3a6q | FMN | FMN-binding protein | / | 0.470 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.470 | |
| 3udk | 095 | Beta-secretase 1 | 3.4.23.46 | 0.470 | |
| 4bah | MEL | Prothrombin | 3.4.21.5 | 0.470 | |
| 7kme | ACE_0BN_CHG_PRR | Prothrombin | 3.4.21.5 | 0.470 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 2pcm | SAH | Diphthine synthase | / | 0.469 | |
| 2x86 | ADP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.469 | |
| 3f68 | 91U | Prothrombin | 3.4.21.5 | 0.469 | |
| 3faz | NOS | Purine nucleoside phosphorylase | / | 0.469 | |
| 4af6 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.469 | |
| 4isg | 1FY | Glucokinase | 2.7.1.2 | 0.469 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.468 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.468 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.468 | |
| 2zf0 | 51U | Prothrombin | 3.4.21.5 | 0.468 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.468 | |
| 3e6e | DCS | Alanine racemase | / | 0.468 | |
| 3nx2 | FER | Ferulic acid decarboxylase | / | 0.468 | |
| 3qft | FAD | NADPH--cytochrome P450 reductase | / | 0.468 | |
| 4j0p | 1H8 | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 1e64 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.467 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.467 | |
| 1qgy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.467 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.467 | |
| 1ypk | CCR | Prothrombin | 3.4.21.5 | 0.467 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.467 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.467 | |
| 2ehl | SAH | Diphthine synthase | / | 0.467 | |
| 2ek4 | SAH | Diphthine synthase | / | 0.467 | |
| 2r6g | ATP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.467 | |
| 2rc6 | FAD | Ferredoxin--NADP reductase | / | 0.467 | |
| 2zff | 53U | Prothrombin | 3.4.21.5 | 0.467 | |
| 3dux | 64U | Prothrombin | 3.4.21.5 | 0.467 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.467 | |
| 4rhe | FMN | Flavin prenyltransferase UbiX | / | 0.467 | |
| 1ae8 | AZL | Prothrombin | 3.4.21.5 | 0.466 | |
| 1c0a | AMO | Aspartate--tRNA ligase | / | 0.466 | |
| 1g7u | PEP | 2-dehydro-3-deoxyphosphooctonate aldolase | 2.5.1.55 | 0.466 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.466 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.466 | |
| 2gs9 | SAH | Uncharacterized protein | / | 0.466 | |
| 2ipj | FFA | Aldo-keto reductase family 1 member C2 | / | 0.466 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.466 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.466 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.466 | |
| 3gds | VAL_TYR_TYR_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.466 | |
| 3hy9 | 098 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.466 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.466 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 4emr | MGP | Ribosome inactivating protein | / | 0.466 | |
| 4gd9 | BTN | Streptavidin | / | 0.466 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.466 | |
| 1qvu | PRL | HTH-type transcriptional regulator QacR | / | 0.465 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.465 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.465 | |
| 3bnk | FMN | Flavoredoxin | / | 0.465 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 3h0v | M2T | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.465 | |
| 3s7d | LEU_SER_LYS_LYS_MLZ | N-lysine methyltransferase SMYD2 | / | 0.465 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.465 | |
| 4drn | 0MC | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.465 | |
| 4kou | C04 | Uncharacterized protein | / | 0.465 | |
| 1dnp | MHF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.464 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.464 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.464 | |
| 2dg4 | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.464 | |
| 2vb8 | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.464 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.464 | |
| 3mhp | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.464 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 4dpe | NGH | Stromelysin-1 | 3.4.24.17 | 0.464 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.464 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.464 | |
| 5ds3 | 09L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.464 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.463 | |
| 1wng | SAH | Diphthine synthase | / | 0.463 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 2a2d | ANP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.463 | |
| 2zda | 32U | Prothrombin | 3.4.21.5 | 0.463 | |
| 2ziq | 26U | Prothrombin | 3.4.21.5 | 0.463 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.463 | |
| 4j3l | AJ5 | Tankyrase-2 | 2.4.2.30 | 0.463 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.463 | |
| 4u7w | NDP | MxaA | / | 0.463 | |
| 1mu6 | CDA | Prothrombin | 3.4.21.5 | 0.462 | |
| 1que | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.462 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.462 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.462 | |
| 2e16 | SAH | Diphthine synthase | / | 0.462 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.462 | |
| 3bi4 | 298 | Polyamine oxidase FMS1 | / | 0.462 | |
| 4jtr | IBP | Aldo-keto reductase family 1 member C2 | / | 0.462 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.461 | |
| 1ta2 | 176 | Prothrombin | 3.4.21.5 | 0.461 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 2gfx | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.461 | |
| 2znk | 31U | Prothrombin | 3.4.21.5 | 0.461 | |
| 3dz7 | O8M | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.461 | |
| 3g11 | P9C | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.461 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.461 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.461 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.461 | |
| 4eil | UMP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.461 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.461 | |
| 4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.461 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.461 | |
| 4l7g | 1W0 | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4m0c | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.461 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.460 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.460 | |
| 1u2r | SO1 | Elongation factor 2 | / | 0.460 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.460 | |
| 2egl | SAH | Diphthine synthase | / | 0.460 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.460 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.460 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.460 | |
| 2xpc | 051 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.460 | |
| 2zfp | 19U | Prothrombin | 3.4.21.5 | 0.460 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.460 | |
| 3pl8 | FAD | Pyranose 2-oxidase | / | 0.460 | |
| 3qto | 10P | Prothrombin | 3.4.21.5 | 0.460 | |
| 3swc | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.460 | |
| 3w5u | FAD | Ferredoxin | / | 0.460 | |
| 1b2r | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.459 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.459 | |
| 1pwy | AC2 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.459 | |
| 1w19 | T1P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.459 | |
| 1zrb | 062 | Prothrombin | 3.4.21.5 | 0.459 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.459 | |
| 2vq7 | FAD | Putative flavin-containing monooxygenase | / | 0.459 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.459 | |
| 2zfq | 45U | Prothrombin | 3.4.21.5 | 0.459 | |
| 3biv | 11U | Prothrombin | 3.4.21.5 | 0.459 | |
| 3dr7 | GPD | GDP-perosamine synthase | / | 0.459 | |
| 3up0 | D7S | aceDAF-12 | / | 0.459 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.459 | |
| 4c0b | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.459 | |
| 4jq1 | NPS | Aldo-keto reductase family 1 member C2 | / | 0.459 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.458 | |
| 2jh6 | 894 | Prothrombin | 3.4.21.5 | 0.458 | |
| 2pca | SAH | Diphthine synthase | / | 0.458 | |
| 2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.458 | |
| 3a26 | MTA | tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase | / | 0.458 | |
| 3b6p | TMP | Three-prime repair exonuclease 1 | 3.1.11.2 | 0.458 | |
| 3uph | 0C1 | Genome polyprotein | 2.7.7.48 | 0.458 | |
| 3vo2 | FAD | Ferredoxin--NADP reductase | / | 0.458 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.458 | |
| 4frj | DWB | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 4jpc | 1M6 | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.458 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 1j4h | SUB | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.457 | |
| 1lvu | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.457 | |
| 2dxw | SAH | Diphthine synthase | / | 0.457 | |
| 2owg | SAH | Diphthine synthase | / | 0.457 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3aut | NAI | Glucose 1-dehydrogenase 4 | 1.1.1.47 | 0.457 | |
| 3epx | IMQ | IAG-nucleoside hydrolase | / | 0.457 | |
| 3fpj | SAM | Uncharacterized protein | / | 0.457 | |
| 3h0b | B35 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.457 | |
| 3o5r | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.457 | |
| 4afe | GGY | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.457 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.457 | |
| 4bs4 | A64 | Tankyrase-2 | 2.4.2.30 | 0.457 | |
| 4djx | 0KQ | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4du6 | GTP | GTP cyclohydrolase 1 | / | 0.457 | |
| 4f6w | 0SS | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.457 | |
| 1a8r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.456 | |
| 1ny2 | ARG_PRO_PRO_GLY | Prothrombin | 3.4.21.5 | 0.456 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.456 | |
| 2aq7 | TL5 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.456 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.456 | |
| 3h7r | NAP | Aldo-keto reductase family 4 member C8 | / | 0.456 | |
| 3ndj | JHZ | Methyltransferase | / | 0.456 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.456 | |
| 4ha6 | PXM | Pyridoxine 4-oxidase | / | 0.456 | |
| 5i9e | ATP | Actin-related protein 4 | / | 0.456 | |
| 1ddu | DDU | Thymidylate synthase | / | 0.455 | |
| 1ewy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.455 | |
| 1iay | AVG | 1-aminocyclopropane-1-carboxylate synthase 2 | 4.4.1.14 | 0.455 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.455 | |
| 1qpl | 587 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.455 | |
| 1rsg | FAD | Polyamine oxidase FMS1 | / | 0.455 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.455 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.455 | |
| 2ejz | SAH | Diphthine synthase | / | 0.455 | |
| 2huv | SAH | Diphthine synthase | / | 0.455 | |
| 2mok | FMN | Flavodoxin 1 | / | 0.455 | |
| 2ovh | AS0 | Progesterone receptor | / | 0.455 | |
| 2r6h | FAD | Na(+)-translocating NADH-quinone reductase subunit F | / | 0.455 | |
| 4dd8 | BAT | Disintegrin and metalloproteinase domain-containing protein 8 | 3.4.24 | 0.455 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.455 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.455 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.455 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.455 | |
| 1kuy | COT | Serotonin N-acetyltransferase | / | 0.454 | |
| 1mma | ADP | Myosin-2 heavy chain | / | 0.454 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.454 | |
| 1q4w | DQU | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.454 | |
| 2dg3 | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.454 | |
| 2ele | SAH | Diphthine synthase | / | 0.454 | |
| 2iu8 | UD1 | UDP-3-O-acylglucosamine N-acyltransferase | 2.3.1 | 0.454 | |
| 2jgs | BTN | Avidin | / | 0.454 | |
| 2of0 | CMZ | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 2p9d | SAH | Diphthine synthase | / | 0.454 | |
| 3beo | UD1 | UDP-N-acetylglucosamine 2-epimerase | / | 0.454 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3vg1 | 0GT | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 3zsr | O3N | Integrase | / | 0.454 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 4ax8 | SAM | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.454 | |
| 4cez | O3N | Integrase | / | 0.454 | |
| 4e2w | JHZ | Methyltransferase | / | 0.454 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.454 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.454 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.453 | |
| 1toj | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.453 | |
| 1vzd | CB3 | Thymidylate synthase | / | 0.453 | |
| 2c42 | TPP | Pyruvate synthase | / | 0.453 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.453 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.453 | |
| 2p5f | SAH | Diphthine synthase | / | 0.453 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.453 | |
| 2qx7 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.453 | |
| 2rfi | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.453 | |
| 2xje | U5P | Cytosolic purine 5'-nucleotidase | 3.1.3.5 | 0.453 | |
| 3ho9 | N3A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.453 | |
| 3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.453 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 3zbt | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.453 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 4br0 | AU1 | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.453 | |
| 4fui | UI3 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.453 | |
| 4j0t | 6T9 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 4l4x | NDP | AmphI | / | 0.453 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.453 | |
| 4xnw | 2ID | P2Y purinoceptor 1 | / | 0.453 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.452 | |
| 1wm1 | PTB | Proline iminopeptidase | 3.4.11.5 | 0.452 | |
| 2dsg | SAH | Diphthine synthase | / | 0.452 | |
| 2e7r | SAH | Diphthine synthase | / | 0.452 | |
| 2e8h | SAH | Diphthine synthase | / | 0.452 | |
| 2el0 | SAH | Diphthine synthase | / | 0.452 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.452 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.452 | |
| 2q3e | NAI | UDP-glucose 6-dehydrogenase | 1.1.1.22 | 0.452 | |
| 2rd2 | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.452 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.452 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.452 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.452 | |
| 3mtw | M3R | Xaa-Pro dipeptidase, putative | / | 0.452 | |
| 4bfp | SWY | Tankyrase-2 | 2.4.2.30 | 0.452 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.452 | |
| 4fiz | CUE | 17beta-hydroxysteroid dehydrogenase | / | 0.452 | |
| 1afe | ALZ | Prothrombin | 3.4.21.5 | 0.451 | |
| 1ddu | CB3 | Thymidylate synthase | / | 0.451 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.451 | |
| 1fkj | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.451 | |
| 1n6l | GTP | Ras-related protein Rab-5A | / | 0.451 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.451 | |
| 1pg2 | ADN | Methionine--tRNA ligase | 6.1.1.10 | 0.451 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.451 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.451 | |
| 1tsv | UMP | Thymidylate synthase | / | 0.451 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.451 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.451 | |
| 2b5o | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.451 | |
| 2cle | F6F | Tryptophan synthase alpha chain | / | 0.451 | |
| 2dxi | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.451 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.451 | |
| 2eka | SAH | Diphthine synthase | / | 0.451 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.451 | |
| 2fxu | BID | Actin, alpha skeletal muscle | / | 0.451 | |
| 2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.451 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.451 | |
| 3vmm | P0D | Alanine--anticapsin ligase | / | 0.451 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.451 | |
| 4rn6 | 15U | Prothrombin | 3.4.21.5 | 0.451 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.451 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.451 | |
| 1bx1 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.450 | |
| 1ef9 | 2CP | Methylmalonyl-CoA decarboxylase | 4.1.1.41 | 0.450 | |
| 1mc0 | PCG | cGMP-dependent 3',5'-cyclic phosphodiesterase | / | 0.450 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.450 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.450 | |
| 2fr1 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.450 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 3e33 | ED7 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.450 | |
| 3iex | GMP | Purine nucleoside phosphorylase | / | 0.450 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.450 | |
| 3rl4 | 5GP | Metallophosphoesterase MPPED2 | 3.1 | 0.450 | |
| 4bao | MVF | Prothrombin | 3.4.21.5 | 0.450 | |
| 4fpy | 0V8 | Sialidase B | 3.2.1.18 | 0.450 | |
| 4l7h | 1W1 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.450 | |
| 4y17 | LAE | Transcriptional regulator of ftsQAZ gene cluster | / | 0.450 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.450 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.449 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1ogj | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.449 | |
| 2ejk | SAH | Diphthine synthase | / | 0.449 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.449 | |
| 2qe2 | 452 | Polyprotein | / | 0.449 | |
| 2qxx | TTP | dCTP deaminase | 3.5.4.13 | 0.449 | |
| 2x90 | EAL | Angiotensin-converting enzyme | 3.4.15.1 | 0.449 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.449 | |
| 3f0a | ACO | Spermidine N(1)-acetyltransferase | / | 0.449 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.449 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.449 | |
| 3iu8 | T03 | Methionine aminopeptidase 2 | / | 0.449 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.449 | |
| 3uxv | GUN | NADPH-dependent 7-cyano-7-deazaguanine reductase | / | 0.449 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.449 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.449 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 4flk | Y10 | Methionine aminopeptidase 1 | / | 0.449 | |
| 4jq2 | SUZ | Aldo-keto reductase family 1 member C2 | / | 0.449 | |
| 1clq | GDP | DNA-directed DNA polymerase | / | 0.448 | |
| 1fkh | SBX | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.448 | |
| 1h5n | PGD | Dimethyl sulfoxide/trimethylamine N-oxide reductase | 1.7.2.3 | 0.448 | |
| 1h69 | ARH | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 1h85 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.448 | |
| 1o2e | ANN | Phospholipase A2 | 3.1.1.4 | 0.448 | |
| 1qy2 | IPZ | Major urinary protein 1 | / | 0.448 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 1t91 | GTP | Ras-related protein Rab-7a | / | 0.448 | |
| 1w76 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 1ypm | RA4 | Prothrombin | 3.4.21.5 | 0.448 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.448 | |
| 2dxv | SAH | Diphthine synthase | / | 0.448 | |
| 2eld | SAH | Diphthine synthase | / | 0.448 | |
| 2iyp | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.448 | |
| 2p6d | SAH | Diphthine synthase | / | 0.448 | |
| 2uuo | LK3 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.448 | |
| 2vdy | HCY | Corticosteroid-binding globulin | / | 0.448 | |
| 2zjn | F1N | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3c0z | SHH | Histone deacetylase 7 | 3.5.1.98 | 0.448 | |
| 3csj | CBL | Glutathione S-transferase P | 2.5.1.18 | 0.448 | |
| 3huc | G97 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3ihz | FK5 | Peptidylprolyl isomerase | / | 0.448 | |
| 3kko | GNP | Ras-related protein M-Ras | / | 0.448 | |
| 3uhm | RFN | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.448 | |
| 3uic | 09T | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.448 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.448 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.448 | |
| 5ilw | URI | Ribosome inactivating protein | / | 0.448 | |
| 5jhn | SAM | Histone-lysine N-methyltransferase EHMT2 | / | 0.448 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.447 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1pua | COA | HAT A1 | / | 0.447 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 1yzq | GNP | Ras-related protein Rab-6A | / | 0.447 | |
| 2bju | IH4 | Plasmepsin-2 | 3.4.23.39 | 0.447 | |
| 2cnt | COA | Ribosomal-protein-alanine acetyltransferase | / | 0.447 | |
| 2pcg | SAH | Diphthine synthase | / | 0.447 | |
| 2pch | SAH | Diphthine synthase | / | 0.447 | |
| 3gco | VAL_TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.447 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.447 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.447 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.447 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.447 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 3tq8 | TOP | Dihydrofolate reductase | / | 0.447 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.447 | |
| 3vjl | W94 | Dipeptidyl peptidase 4 | / | 0.447 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.447 | |
| 4baq | M4Z | Prothrombin | 3.4.21.5 | 0.447 | |
| 4e32 | DWN | Methyltransferase | / | 0.447 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.447 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.447 | |
| 5dsy | UHB | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.447 | |
| 1acj | THA | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.446 | |
| 1i7m | CG | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.446 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.446 | |
| 1muu | GDX | GDP-mannose 6-dehydrogenase | 1.1.1.132 | 0.446 | |
| 1qpf | 858 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.446 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 2aa7 | 1CA | Mineralocorticoid receptor | / | 0.446 | |
| 2e8r | SAH | Diphthine synthase | / | 0.446 | |
| 2v3w | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.446 | |
| 2vat | COA | Acetyl-CoA--deacetylcephalosporin C acetyltransferase | 2.3.1.175 | 0.446 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.446 | |
| 2zrz | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.446 | |
| 3a20 | FMN | FMN-binding protein | / | 0.446 | |
| 3b05 | IPE | Isopentenyl-diphosphate delta-isomerase | / | 0.446 | |
| 3dz6 | M8E | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.446 | |
| 3hnz | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.446 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.446 | |
| 4b1e | 6T6 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4cfc | 7NV | Integrase | / | 0.446 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.446 | |
| 4z4p | SAH | Histone-lysine N-methyltransferase 2D | 2.1.1.43 | 0.446 | |
| 1fnd | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.445 | |
| 1ghv | 120 | Prothrombin | 3.4.21.5 | 0.445 | |
| 1rxj | BNI | Streptavidin | / | 0.445 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.445 | |
| 2egb | SAH | Diphthine synthase | / | 0.445 | |
| 2hut | SAH | Diphthine synthase | / | 0.445 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.445 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.445 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.445 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 2yg4 | FAD | Putrescine oxidase | / | 0.445 | |
| 2zfr | 46U | Prothrombin | 3.4.21.5 | 0.445 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.445 | |
| 3awh | FMN | FMN-binding protein | / | 0.445 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.445 | |
| 3k5d | XLI | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.445 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.445 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.445 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4nbu | CAA | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.445 | |
| 4qen | SAH | Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 | 2.1.1.43 | 0.445 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 4xvr | GNP | GTPase HRas | / | 0.445 | |
| 4xzj | NAD | Putative NAD(+)--arginine ADP-ribosyltransferase Vis | 2.4.2.31 | 0.445 | |
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.445 | |
| 1flm | FMN | FMN-binding protein | / | 0.444 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.444 | |
| 1gj4 | 132 | Prothrombin | 3.4.21.5 | 0.444 | |
| 1opm | IYG | Peptidyl-glycine alpha-amidating monooxygenase | 1.14.17.3 | 0.444 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.444 | |
| 1wli | FMN | FMN-binding protein | / | 0.444 | |
| 1z5v | GSP | Tubulin gamma-1 chain | / | 0.444 | |
| 2e8s | SAH | Diphthine synthase | / | 0.444 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.444 | |
| 2vij | C44 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3bwc | SAM | Spermidine synthase, putative | / | 0.444 | |
| 3qvr | FAD | Glucose oxidase | 1.1.3.4 | 0.444 | |
| 3rdq | DTB | Streptavidin | / | 0.444 | |
| 3reo | SAH | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.444 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.444 | |
| 4bri | UNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.444 | |
| 4c36 | ZO9 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.444 | |
| 4hh4 | SAH | CcbJ | / | 0.444 | |
| 4l6s | 1WQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.444 | |
| 4mfe | BTN | Pyruvate carboxylase | / | 0.444 | |
| 4rrr | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.444 | |
| 4yfy | 1YJ | VioF | / | 0.444 | |
| 5cxv | 0HK | Muscarinic acetylcholine receptor M1 | / | 0.444 | |
| 1a4w | QWE | Prothrombin | 3.4.21.5 | 0.443 | |
| 1bkf | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.443 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.443 | |
| 1xyy | FMN | Flavodoxin | / | 0.443 | |
| 2a2c | ADP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.443 | |
| 2aba | STR | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.443 | |
| 2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.443 | |
| 2egs | SAH | Diphthine synthase | / | 0.443 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2owf | SAH | Diphthine synthase | / | 0.443 | |
| 2owv | SAH | Diphthine synthase | / | 0.443 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.443 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.443 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 2xvv | 9DN | Serum albumin | / | 0.443 | |
| 3cnp | SP7 | Polyamine oxidase FMS1 | / | 0.443 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3e39 | FMN | Nitroreductase | / | 0.443 | |
| 3gey | P34 | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.443 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.443 | |
| 3kdt | 7HA | Peroxisome proliferator-activated receptor alpha | / | 0.443 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3r1r | ATP | Ribonucleoside-diphosphate reductase 1 subunit alpha | 1.17.4.1 | 0.443 | |
| 3r2f | PB0 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4e31 | JHZ | Methyltransferase | / | 0.443 | |
| 4hc4 | SAH | Protein arginine N-methyltransferase 6 | / | 0.443 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.443 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.443 | |
| 5hwp | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.443 | |
| 1by5 | GLY_GLY_GLY_AHO_AHO_AHO_FE | Ferrichrome-iron receptor | / | 0.442 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 1nja | DCM | Thymidylate synthase | / | 0.442 | |
| 1ogi | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.442 | |
| 1q3h | ANP | Cystic fibrosis transmembrane conductance regulator | / | 0.442 | |
| 1w51 | L01 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 1ywg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.442 | |
| 2bt4 | CA2 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.442 | |
| 2dek | SAH | Diphthine synthase | / | 0.442 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.442 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.442 | |
| 2wqo | VGK | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.442 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.442 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.442 | |
| 3c4h | DRL | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.442 | |
| 3frk | TQP | QdtB | / | 0.442 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.442 | |
| 3ox3 | 4X4 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
| 3ske | 054 | Genome polyprotein | 2.7.7.48 | 0.442 | |
| 4d03 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.442 | |
| 4g67 | SAH | Uncharacterized ACR, COG1565 superfamily | / | 0.442 | |
| 4lol | 1YE | Stimulator of interferon genes protein | / | 0.442 | |
| 4wxf | PLG | Serine hydroxymethyltransferase | / | 0.442 | |
| 5bnw | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.442 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.441 | |
| 1mxf | MTX | Putative pteridine reductase 2 | / | 0.441 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.441 | |
| 1q13 | TES | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.441 | |
| 1s17 | GNR | Peptide deformylase | / | 0.441 | |
| 1sm4 | FAD | Ferredoxin--NADP reductase | / | 0.441 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.441 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1umk | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.441 | |
| 2f99 | AKV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.441 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.441 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.441 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.441 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 2wm3 | NFL | NmrA-like family domain-containing protein 1 | / | 0.441 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.441 | |
| 3bbp | GTP | Ras-related protein Rab-6A | / | 0.441 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3ntq | NAD | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.441 | |
| 3o0o | GDP | Vitamin B12-dependent ribonucleotide reductase | / | 0.441 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.441 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3v2u | ATP | Protein GAL3 | / | 0.441 | |
| 3wqu | ATP | Cell division protein FtsA | / | 0.441 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.441 | |
| 4dch | 4DC | Glucokinase | 2.7.1.2 | 0.441 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 4jv3 | N32 | Beta-ketoacyl synthase | / | 0.441 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.441 | |
| 4s1h | ADP | Pyridoxal kinase, putative | / | 0.441 | |
| 4z87 | GDP | Inosine-5'-monophosphate dehydrogenase | / | 0.441 | |
| 1a26 | CNA | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.440 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.440 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.440 | |
| 1l2s | STC | Beta-lactamase | 3.5.2.6 | 0.440 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.440 | |
| 1qs2 | NAD | Vip2Ac | / | 0.440 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.440 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.440 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2eh2 | SAH | Diphthine synthase | / | 0.440 | |
| 2eh4 | SAH | Diphthine synthase | / | 0.440 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.440 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.440 | |
| 2zc9 | 22U | Prothrombin | 3.4.21.5 | 0.440 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.440 | |
| 3bhr | THG | Thymidylate synthase | / | 0.440 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3eku | CY9 | Actin-5C | / | 0.440 | |
| 3hat | GLY_VAL_ARG_RNG | Prothrombin | 3.4.21.5 | 0.440 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.440 | |
| 3l9m | L9M | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.440 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.440 | |
| 4b64 | NAP | L-ornithine N(5)-monooxygenase | / | 0.440 | |
| 4ck2 | NVU | Integrase | / | 0.440 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.440 | |
| 4jqa | ID8 | Aldo-keto reductase family 1 member C2 | / | 0.440 | |
| 4k4f | K4F | Tankyrase-1 | 2.4.2.30 | 0.440 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.440 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.440 | |
| 4rri | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.440 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.440 | |
| 5erm | 210 | Fusicoccadiene synthase | 4.2.3.43 | 0.440 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.440 |