sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5dw5 | 0T1 | Succinyl-CoA:acetate CoA-transferase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 5dw5 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 1.000 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.660 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.613 | |
| 4eua | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.574 | |
| 4eu4 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.529 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.527 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.518 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.516 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.506 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.499 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.497 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.495 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.495 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.494 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.494 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.494 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.492 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.491 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.490 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.490 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.489 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.487 | |
| 3eks | CY9 | Actin-5C | / | 0.486 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.486 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.486 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.484 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.484 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.483 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.482 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.482 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.482 | |
| 1r6t | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.481 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.481 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.481 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.481 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.480 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.480 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.479 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.479 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.478 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.478 | |
| 2ilv | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.478 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.478 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.478 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.477 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.477 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.477 | |
| 4wso | NAD | Probable nicotinate-nucleotide adenylyltransferase | / | 0.477 | |
| 3duy | AFJ | Beta-secretase 1 | 3.4.23.46 | 0.476 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.476 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.476 | |
| 3ty3 | GGG | Homoisocitrate dehydrogenase | 1.1.1.87 | 0.476 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.476 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.476 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.476 | |
| 1a9c | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.475 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.475 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.475 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.475 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.475 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.474 | |
| 3a3g | DLZ | Lumazine protein | / | 0.474 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.474 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.474 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.474 | |
| 4a0r | DTB | Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial | 6.3.3.3 | 0.474 | |
| 1kp3 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.473 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.473 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.473 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.473 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.473 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.473 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.473 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.473 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.473 | |
| 3ll9 | ADP | Isopentenyl phosphate kinase | / | 0.473 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.473 | |
| 4y35 | F90 | Endothiapepsin | 3.4.23.22 | 0.473 | |
| 1vjt | NAD | Alpha-glucosidase, putative | / | 0.472 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.472 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.472 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.472 | |
| 4yj2 | GTP | Tubulin alpha-1B chain | / | 0.472 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.471 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.471 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.471 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.471 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.471 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.470 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.470 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.470 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.470 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1wng | SAH | Diphthine synthase | / | 0.469 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.469 | |
| 3o0o | 5AD | Vitamin B12-dependent ribonucleotide reductase | / | 0.469 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.468 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.468 | |
| 2ntr | L00 | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.467 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.467 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.467 | |
| 1uma | IN2 | Prothrombin | 3.4.21.5 | 0.467 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.467 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.467 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.467 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.467 | |
| 4iv6 | FDA | Isovaleryl-CoA dehydrogenase | / | 0.467 | |
| 4zow | CLM | Multidrug transporter MdfA | / | 0.467 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.467 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.466 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.466 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.466 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.466 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.466 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.466 | |
| 4brd | ANP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.466 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.466 | |
| 4xrb | NDP | Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc | / | 0.466 | |
| 5dp2 | NAP | CurF | / | 0.466 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.465 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.465 | |
| 2wf1 | ZY1 | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.465 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.465 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.464 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.464 | |
| 2ozu | ACO | Histone acetyltransferase KAT6A | / | 0.464 | |
| 2p9g | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.464 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.464 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.463 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.463 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.463 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 3zid | GDP | Tubulin-like protein CetZ | / | 0.463 | |
| 3vw7 | VPX | Proteinase-activated receptor 1 | / | 0.463 | |
| 1d2h | SAH | Glycine N-methyltransferase | 2.1.1.20 | 0.462 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.462 | |
| 2f99 | AKV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.462 | |
| 2fre | FMN | NAD(P)H-flavin oxidoreductase | / | 0.462 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.462 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.462 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.462 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.462 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.462 | |
| 4djh | JDC | Kappa-type opioid receptor | / | 0.462 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 2gz8 | F3F | Orf1a polyprotein | / | 0.461 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.461 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.461 | |
| 3eku | CY9 | Actin-5C | / | 0.461 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.461 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.461 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.461 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.461 | |
| 4nau | AGS | Phosphopantetheine adenylyltransferase | / | 0.461 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.461 | |
| 5dld | UD1 | UDP-N-Acetylglucosamine 2-epimerase | / | 0.461 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.460 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.460 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 1vhz | APR | ADP compounds hydrolase NudE | 3.6.1 | 0.460 | |
| 1zdw | FLV | Prenyltransferase | / | 0.460 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.460 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.460 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.460 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.460 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.460 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.460 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.460 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.460 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.459 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.459 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.459 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.459 | |
| 2uuv | FAD | Alkyldihydroxyacetonephosphate synthase | 2.5.1.26 | 0.459 | |
| 2ylr | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.459 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.459 | |
| 3u33 | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.459 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.459 | |
| 1omo | NAD | Alanine dehydrogenase | / | 0.458 | |
| 1u33 | LM2 | Pancreatic alpha-amylase | / | 0.458 | |
| 1uxy | EPU | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.458 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.458 | |
| 2fut | H1S | Heparin and heparin-sulfate lyase | / | 0.458 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.458 | |
| 3hxf | BD9 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.458 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.458 | |
| 3pgi | F41 | Endothiapepsin | 3.4.23.22 | 0.458 | |
| 3t64 | DU3 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | / | 0.458 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.458 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.458 | |
| 4z26 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.458 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.457 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.457 | |
| 1ra3 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.457 | |
| 2e07 | SAH | Diphthine synthase | / | 0.457 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.457 | |
| 3bbr | BHY | Glutamate receptor 2 | / | 0.457 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.457 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.457 | |
| 3ivg | FG5 | Pantothenate synthetase | 6.3.2.1 | 0.457 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.457 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.457 | |
| 4tyq | AP5 | Adenylate kinase | / | 0.457 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.457 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1k4m | NAD | Nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.456 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.456 | |
| 1yqs | BSA | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.456 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.456 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.456 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.456 | |
| 3n19 | FNR | Xenobiotic reductase | / | 0.456 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.456 | |
| 4ef4 | C2E | Stimulator of interferon genes protein | / | 0.456 | |
| 5c77 | SAH | Protein arginine N-methyltransferase SFM1 | / | 0.456 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.455 | |
| 1kvu | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.455 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.455 | |
| 2eh4 | SAH | Diphthine synthase | / | 0.455 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 3dv3 | MEK | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.455 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.455 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.455 | |
| 3v2u | ATP | Protein GAL3 | / | 0.455 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.455 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.455 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 4e2d | FMN | Dehydrogenase | / | 0.455 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.455 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.455 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.455 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.455 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.454 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.454 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.454 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.454 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.454 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.454 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.454 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.454 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.454 | |
| 3vil | SA0 | Beta-glucosidase | / | 0.454 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.454 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.454 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 4lcn | GNG | Cytidine and deoxycytidylate deaminase zinc-binding region | / | 0.454 | |
| 1fml | RTL | Retinol dehydratase | / | 0.453 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.453 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.453 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.453 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.453 | |
| 2hu2 | NAD | C-terminal binding protein 1 | / | 0.453 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.453 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.453 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.453 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.453 | |
| 3kxw | 1ZZ | Saframycin Mx1 synthetase B | / | 0.453 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.453 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.453 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.453 | |
| 5k7u | SAM | N6-adenosine-methyltransferase 70 kDa subunit | / | 0.453 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.452 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.452 | |
| 1ra3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.452 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.452 | |
| 2dc1 | NAD | Probable L-aspartate dehydrogenase | / | 0.452 | |
| 2ejz | SAH | Diphthine synthase | / | 0.452 | |
| 2ien | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.452 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.452 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.452 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.452 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.452 | |
| 3w1q | YRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.452 | |
| 4f9g | C2E | Stimulator of interferon genes protein | / | 0.452 | |
| 4fpy | 0V8 | Sialidase B | 3.2.1.18 | 0.452 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.452 | |
| 4wud | ANP | DNA gyrase subunit B | / | 0.452 | |
| 4xsv | CTP | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.452 | |
| 1bdb | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | / | 0.451 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.451 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.451 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.451 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.451 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.451 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.451 | |
| 2i3g | NAP | N-acetyl-gamma-glutamyl-phosphate reductase | 1.2.1.38 | 0.451 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.451 | |
| 2oeg | UPG | UDP-glucose pyrophosphorylase | / | 0.451 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.451 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.451 | |
| 3em3 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3gf4 | UPG | UDP-galactopyranose mutase | 5.4.99.9 | 0.451 | |
| 3ggo | NAI | Prephenate dehydrogenase | / | 0.451 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3oix | FMN | Dihydroorotate dehydrogenase | / | 0.451 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.451 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.451 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.451 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4l4x | NDP | AmphI | / | 0.451 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.451 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.451 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.450 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.450 | |
| 1kbi | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.450 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.450 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.450 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.450 | |
| 2e8h | SAH | Diphthine synthase | / | 0.450 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.450 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.450 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.450 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.450 | |
| 2yd0 | BES | Endoplasmic reticulum aminopeptidase 1 | 3.4.11 | 0.450 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.450 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.450 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.450 | |
| 4do3 | 0LA | Fatty-acid amide hydrolase 1 | 3.5.1.99 | 0.450 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4j75 | TYM | Tryptophan--tRNA ligase | / | 0.450 | |
| 4x7v | MIV | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.450 | |
| 5ftf | ADP | TPR domain protein | / | 0.450 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1toj | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.449 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.449 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.449 | |
| 2b4r | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.449 | |
| 2hux | SAH | Diphthine synthase | / | 0.449 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.449 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.449 | |
| 2rc4 | ACO | Histone acetyltransferase KAT6A | / | 0.449 | |
| 2xfi | XFI | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 3e6e | DCS | Alanine racemase | / | 0.449 | |
| 3go4 | SAH | Uncharacterized protein | / | 0.449 | |
| 3ksq | Z96 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.449 | |
| 3o0q | ADN | Vitamin B12-dependent ribonucleotide reductase | / | 0.449 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.449 | |
| 3toz | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.449 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.449 | |
| 4yak | ACO | Acyl-CoA synthetase (NDP forming) | / | 0.449 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.448 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.448 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.448 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.448 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.448 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.448 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.448 | |
| 2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.448 | |
| 2hpv | FMN | FMN-dependent NADH-azoreductase | 1.7 | 0.448 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.448 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.448 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.448 | |
| 3b7d | CNI | Glutamate receptor 2 | / | 0.448 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.448 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.448 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.448 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.448 | |
| 4f5y | C2E | Stimulator of interferon genes protein | / | 0.448 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.448 | |
| 4z87 | 5GP | Inosine-5'-monophosphate dehydrogenase | / | 0.448 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.448 | |
| 1e81 | M91 | Endothiapepsin | 3.4.23.22 | 0.447 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.447 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.447 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.447 | |
| 1jcq | 739 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.447 | |
| 2ome | NAD | C-terminal-binding protein 2 | / | 0.447 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.447 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.447 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3wag | TYD | Glycosyltransferase | / | 0.447 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.447 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.447 | |
| 4eu5 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.447 | |
| 4yjd | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.447 | |
| 1aka | PLP | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.446 | |
| 1c9k | 5GP | Bifunctional adenosylcobalamin biosynthesis protein CobU | / | 0.446 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.446 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.446 | |
| 1kh3 | ANP | Argininosuccinate synthase | / | 0.446 | |
| 1n77 | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.446 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.446 | |
| 1udc | UFM | UDP-glucose 4-epimerase | 5.1.3.2 | 0.446 | |
| 2bsx | NOS | Purine nucleoside phosphorylase | / | 0.446 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.446 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.446 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.446 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.446 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.446 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.446 | |
| 3a37 | ADP | ATPase GET3 | / | 0.446 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.446 | |
| 3gon | ANP | Phosphomevalonate kinase | / | 0.446 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.446 | |
| 3l9h | EMQ | Kinesin-like protein KIF11 | / | 0.446 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.446 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.446 | |
| 4lut | DCS | Alanine racemase | / | 0.446 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.446 | |
| 5cku | FAD | L-ornithine N(5)-monooxygenase | / | 0.446 | |
| 6req | 3CP | Methylmalonyl-CoA mutase large subunit | 5.4.99.2 | 0.446 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.446 | |
| 8dfr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.445 | |
| 1d0l | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.445 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1n4q | LYS_CYS_VAL_ILE_LEU | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.445 | |
| 1p4a | PCP | Pur operon repressor | / | 0.445 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.445 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.445 | |
| 1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.445 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.445 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.445 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.445 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.445 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.445 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2j07 | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.445 | |
| 2nx3 | PEP | 2-dehydro-3-deoxyphosphooctonate aldolase | 2.5.1.55 | 0.445 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.445 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.445 | |
| 3e32 | ED2 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.445 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.445 | |
| 4adc | PLP | Succinylornithine transaminase | 2.6.1.81 | 0.445 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.445 | |
| 4eue | NAI | Trans-2-enoyl-CoA reductase [NADH] | / | 0.445 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.445 | |
| 4u0m | ATP | Cyclic GMP-AMP synthase | / | 0.445 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.445 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.445 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.444 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1f8w | FAD | NADH peroxidase | 1.11.1.1 | 0.444 | |
| 1ndi | COA | Carnitine O-acetyltransferase | 2.3.1.7 | 0.444 | |
| 1vji | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.444 | |
| 1zp4 | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.444 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.444 | |
| 2v2q | NVG | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.444 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.444 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.444 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.444 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.444 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.444 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4dja | FAD | (6-4) photolyase | / | 0.444 | |
| 4euc | 0RQ | Succinyl-CoA:acetate CoA-transferase | / | 0.444 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.444 | |
| 4ge9 | 0L0 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.444 | |
| 4l7f | 1V5 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.444 | |
| 4nes | UD1 | UDP-N-acetylglucosamine 2-epimerase | 5.1.3.14 | 0.444 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.444 | |
| 4usr | FAD | Monooxygenase | / | 0.444 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.444 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.444 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.444 | |
| 1i6k | TYM | Tryptophan--tRNA ligase | 6.1.1.2 | 0.443 | |
| 1pz0 | NAP | Protein IolS | 1.1.1 | 0.443 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.443 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2fxu | BID | Actin, alpha skeletal muscle | / | 0.443 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.443 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.443 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.443 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.443 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.443 | |
| 3axk | NDP | Ribulose bisphosphate carboxylase large chain | 4.1.1.39 | 0.443 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.443 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.443 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.443 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.443 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.443 | |
| 4ef8 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.443 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.443 | |
| 1a5b | IGP | Tryptophan synthase alpha chain | / | 0.442 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.442 | |
| 1hdo | NAP | Flavin reductase (NADPH) | / | 0.442 | |
| 1j21 | ATP | Argininosuccinate synthase | / | 0.442 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.442 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.442 | |
| 1rsg | FAD | Polyamine oxidase FMS1 | / | 0.442 | |
| 2cft | PLP | Pyridoxal phosphate phosphatase | / | 0.442 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.442 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 3lq4 | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.442 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.442 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.442 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.442 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.442 | |
| 3vg1 | 0GT | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3vx4 | ATP | Putative ABC transporter, ATP-binding protein ComA | / | 0.442 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.442 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.442 | |
| 4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.442 | |
| 4na4 | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.442 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.442 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.442 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.441 | |
| 1c7o | PPG | Hemolysin | / | 0.441 | |
| 1h65 | GDP | Translocase of chloroplast 34 | 3.6.5 | 0.441 | |
| 1msm | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.441 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.441 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.441 | |
| 2bz5 | AB4 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2d3a | ADP | Glutamine synthetase root isozyme 3 | 6.3.1.2 | 0.441 | |
| 2fje | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.441 | |
| 2q3r | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.441 | |
| 2qc8 | ADP | Glutamine synthetase | 6.3.1.2 | 0.441 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.441 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.441 | |
| 2zrx | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.441 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 3fst | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.441 | |
| 3ilt | TRU | Glutamate receptor 2 | / | 0.441 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.441 | |
| 3uox | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.441 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4ew2 | DXY | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.441 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.441 | |
| 4jic | FMN | GTN Reductase | / | 0.441 | |
| 4js1 | CTN | Beta-galactoside alpha-2,6-sialyltransferase 1 | 2.4.99.1 | 0.441 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.441 | |
| 4xgi | NAD | Glutamate dehydrogenase | / | 0.441 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.441 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.441 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.440 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.440 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1w19 | T1P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 1z41 | FMN | NADPH dehydrogenase | / | 0.440 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.440 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.440 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.440 | |
| 2qta | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.440 | |
| 2qzl | IXS | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.440 | |
| 3dr7 | GPD | GDP-perosamine synthase | / | 0.440 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.440 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.440 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.440 | |
| 3gwd | NAP | Cyclohexanone monooxygenase | / | 0.440 | |
| 3kkz | SAM | Uncharacterized protein | / | 0.440 | |
| 3kt3 | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.440 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.440 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.440 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.440 | |
| 3wsw | NAD | L-lactate dehydrogenase | / | 0.440 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.440 | |
| 4c36 | ZO9 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 4emd | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.440 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.440 | |
| 4gtp | 7TP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 4ha9 | NDP | 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase | 1.1.1.302 | 0.440 | |
| 4jc5 | 1K5 | Stimulator of interferon genes protein | / | 0.440 | |
| 4o63 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.440 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.440 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.440 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 | |
| 4y1b | NAP | AntE | / | 0.440 | |
| 5c41 | ACP | Ribokinase | / | 0.440 |