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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4a9nA9NBromodomain-containing protein 2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4a9nA9NBromodomain-containing protein 2/1.000
4a9oA9OBromodomain-containing protein 2/0.671
4aknS5BBromodomain-containing protein 2/0.664
4uyf73BBromodomain-containing protein 2/0.637
3aqaBYHBromodomain-containing protein 2/0.621
4bjx73BBromodomain-containing protein 4/0.621
4o701QKBromodomain-containing protein 4/0.613
4bw1S5BBromodomain-containing protein 4/0.597
3zyu1GHBromodomain-containing protein 4/0.593
4o761M3Bromodomain-containing protein 4/0.593
4lrg1XBBromodomain-containing protein 4/0.591
4c67L5SBromodomain-containing protein 4/0.589
4c66H4CBromodomain-containing protein 4/0.586
2ydwWSHBromodomain-containing protein 2/0.585
4men25KBromodomain-containing protein 4/0.583
4a9mP9MBromodomain-containing protein 2/0.580
2yelWSHBromodomain-containing protein 4/0.578
4j0r1H2Bromodomain-containing protein 4/0.574
4nqmY1ZBromodomain-containing protein 4/0.574
4flpJQ1Bromodomain testis-specific protein/0.573
4bw39BMBromodomain-containing protein 4/0.570
4mr41K0Bromodomain-containing protein 4/0.570
4alhA9PBromodomain-containing protein 2/0.569
4a9lP9LBromodomain-containing protein 4/0.568
4a9iP9IBromodomain-containing protein 2/0.564
4ogiR78Bromodomain-containing protein 4/0.564
4hxs1A3Bromodomain-containing protein 4/0.557
4j0s1H3Bromodomain-containing protein 4/0.554
4j3i1K0Bromodomain-containing protein 4/0.554
4lyw21QBromodomain-containing protein 4/0.551
4o74R78Bromodomain-containing protein 4/0.551
4uyg73BBromodomain-containing protein 2/0.551
4a9hTVPBromodomain-containing protein 2/0.549
4bw2UTHBromodomain-containing protein 4/0.549
4f3i0S6Bromodomain-containing protein 4/0.549
4alg1GHBromodomain-containing protein 2/0.548
4a9e3PFBromodomain-containing protein 2/0.542
4lr61XABromodomain-containing protein 4/0.542
5bt52LOBromodomain-containing protein 2/0.542
4qzsJQ1Bromodomain-containing protein 4/0.541
4hby13FBromodomain-containing protein 4/0.537
4mep24YBromodomain-containing protein 4/0.537
4hxr1A4Bromodomain-containing protein 4/0.536
4hxo1A6Bromodomain-containing protein 4/0.535
2yemWSHBromodomain-containing protein 4/0.532
2yekEAMBromodomain-containing protein 2/0.531
4j1p1K0Bromodomain-containing protein 2/0.529
4bw49B6Bromodomain-containing protein 4/0.527
4nr52LLCREB-binding protein/0.527
3lpbNVBTyrosine-protein kinase JAK2/0.515
4o71CPBBromodomain-containing protein 4/0.512
4cfl8DQBromodomain-containing protein 4/0.509
4meq25OBromodomain-containing protein 4/0.506
4mr61K0Bromodomain-containing protein 2/0.504
4hbw14ZBromodomain-containing protein 4/0.500
4meo25VBromodomain-containing protein 4/0.497
4nyv15ECREB-binding protein/0.497
4hxn1A7Bromodomain-containing protein 4/0.492
4gpj0Q1Bromodomain-containing protein 4/0.491
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.489
4ia3BIVVitamin D3 receptor A/0.488
1bygSTUTyrosine-protein kinase CSK/0.487
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.486
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.485
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.484
4py6R78Bromodomain protein, putative/0.483
2vn0TDZCytochrome P450 2C8/0.482
3ddw055Glycogen phosphorylase, liver form2.4.1.10.482
2a1tFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.481
4nr82LLBromodomain-containing protein 4/0.481
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.480
4uymVOR14-alpha sterol demethylase Cyp51B/0.480
2ic3HBYGag-Pol polyprotein2.7.7.490.479
3wowANPCasein kinase II subunit alpha2.7.11.10.479
4l8u9AZSerum albumin/0.479
1dirNADDihydropteridine reductase1.5.1.340.478
3mdmFJZCholesterol 24-hydroxylase/0.478
3vt8YI3Vitamin D3 receptor/0.477
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.477
4mr51K0Bromodomain-containing protein 2/0.476
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.475
2po7CHDFerrochelatase, mitochondrial4.99.1.10.475
2zjwREFCasein kinase II subunit alpha2.7.11.10.475
3pgqGY3Acetyl-CoA carboxylase/0.475
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.474
2ejvNADL-threonine 3-dehydrogenase/0.474
2hcdBIVVitamin D3 receptor A/0.474
2wufKEM4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.474
4o78SAVBromodomain-containing protein 4/0.473
1bwsNDPGDP-L-fucose synthase/0.471
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.471
2wqeADPAurora kinase A2.7.11.10.471
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.470
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.470
3at4CCKCasein kinase II subunit alpha2.7.11.10.470
4e960NSBromodomain-containing protein 4/0.470
4ia2BIVVitamin D3 receptor A/0.470
4ryvZEAProtein LlR18A/0.470
1oc1ASVIsopenicillin N synthase1.21.3.10.469
1pjkANPCasein kinase II subunit alpha2.7.11.10.469
1rbmKT5Trifunctional purine biosynthetic protein adenosine-32.1.2.20.469
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.469
2hk9NAPShikimate dehydrogenase (NADP(+))/0.469
4aqc88ATyrosine-protein kinase JAK2/0.469
4ir5IR5Bromodomain adjacent to zinc finger domain protein 2B/0.469
4riyADPEpidermal growth factor receptor2.7.10.10.469
3be9P04Casein kinase II subunit alpha2.7.11.10.468
3pm9FADPutative oxidoreductase/0.468
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.468
1eh4IC1Casein kinase I homolog 12.7.11.10.467
1jpaANPEphrin type-B receptor 22.7.10.10.467
3imxB84Glucokinase2.7.1.20.467
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.467
3pxkPXKFocal adhesion kinase 12.7.10.20.466
4enhFVXCholesterol 24-hydroxylase/0.466
4rw6494Gag-Pol polyprotein2.7.7.490.466
4wkqIREEpidermal growth factor receptor2.7.10.10.466
4xgxADPFAD:protein FMN transferase/0.466
2pvnP63Casein kinase II subunit alpha2.7.11.10.465
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.465
4ia1BIVVitamin D3 receptor A/0.465
4ia7BIVVitamin D3 receptor A/0.465
1bsvNDPGDP-L-fucose synthase/0.464
3gobHXXDdmC/0.464
3vt7VDXVitamin D3 receptor/0.464
3vt9YI4Vitamin D3 receptor/0.464
4cukNAID-lactate dehydrogenase/0.464
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.464
3da1FADGlycerol-3-phosphate dehydrogenase/0.463
3gcoVAL_TYR_GLN_PHESerine endoprotease DegS3.4.21.1070.463
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.463
3m7rVDXVitamin D3 receptor/0.463
3mtfA3FActivin receptor type-12.7.11.300.463
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.463
3qqkX02Cyclin-dependent kinase 22.7.11.220.463
4nmbFADBifunctional protein PutA/0.463
1eioGCHGastrotropin/0.462
1uy7PU4Heat shock protein HSP 90-alpha/0.462
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.462
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.462
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.462
3pgpACOUncharacterized protein/0.462
4deaNHIAurora kinase A2.7.11.10.462
1h1s4SPCyclin-dependent kinase 22.7.11.220.461
1phgMYTCamphor 5-monooxygenase1.14.15.10.461
1uzwCDHIsopenicillin N synthase1.21.3.10.461
2cibCM6Lanosterol 14-alpha demethylase1.14.13.700.461
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.461
2pwlACPFibroblast growth factor receptor 2/0.461
2z97CAMCamphor 5-monooxygenase1.14.15.10.461
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.461
3svgODRBromodomain-containing protein 4/0.461
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
4wa9AXITyrosine-protein kinase ABL12.7.10.20.461
5e8wSTUTGF-beta receptor type-12.7.11.300.461
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
5eccNAPDehydrofolate reductase type I/0.461
1db1VDXVitamin D3 receptor/0.460
1fmlRTLRetinol dehydratase/0.460
1ia3TQ5Dihydrofolate reductase1.5.1.30.460
1uy8PU5Heat shock protein HSP 90-alpha/0.460
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.460
2j83BATUlilysin3.4.240.460
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.460
3a4vNADNDP-sugar epimerase/0.460
3kpzZNEVitamin D3 receptor/0.460
3mdvCL6Cholesterol 24-hydroxylase/0.460
4iui1GQEstrogen receptor/0.460
1bw9NADPhenylalanine dehydrogenase/0.459
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
2c3qGTXGlutathione S-transferase theta-12.5.1.180.459
2tpsTPSThiamine-phosphate synthase/0.459
3p99LNPLanosterol 14-alpha-demethylase/0.459
3v9v21LPeroxisome proliferator-activated receptor gamma/0.459
3zuyTCHTransporter/0.459
4cfkLY2Bromodomain-containing protein 4/0.459
1dr3HBIDihydrofolate reductase1.5.1.30.458
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.458
1s4dSAHUroporphyrinogen-III C-methyltransferase2.1.1.1070.458
1um8ADPATP-dependent Clp protease ATP-binding subunit ClpX/0.458
1v0pPVBCell division control protein 2 homolog2.7.11.220.458
2givACOHistone acetyltransferase KAT8/0.458
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.458
3iaeD7KBenzaldehyde lyase/0.458
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
3qzgX67Cyclin-dependent kinase 22.7.11.220.458
4gk4L90Ephrin type-A receptor 32.7.10.10.458
4oaeCLMUncharacterized protein/0.458
4ruoBIVVitamin D3 receptor A/0.458
1jipKTN6-deoxyerythronolide B hydroxylase/0.457
2bu9HFVIsopenicillin N synthase1.21.3.10.457
2wotZZGTGF-beta receptor type-12.7.11.300.457
2wueKEK4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.457
2yn8STUEphrin type-B receptor 42.7.10.10.457
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.457
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.457
3il1B5DGlutamate receptor 2/0.457
4c3rACPAurora kinase A2.7.11.10.457
4hge15VTyrosine-protein kinase JAK2/0.457
4mwhATPCasein kinase II subunit alpha2.7.11.10.457
4rupH97Vitamin D3 receptor A/0.457
1k6cMK1Gag-Pol polyprotein3.4.23.160.456
1r2jFADFkbI/0.456
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.456
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.456
4k2xFADPolyketide oxygenase/hydroxylase/0.456
5dfcEAMBromodomain-containing protein 2/0.456
5e92ANPTGF-beta receptor type-22.7.11.300.456
1xefATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.455
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.455
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
2npaMMBPeroxisome proliferator-activated receptor alpha/0.455
2w1fL0FAurora kinase A2.7.11.10.455
3c6uM22Gag-Pol polyprotein2.7.7.490.455
3dds26BGlycogen phosphorylase, liver form2.4.1.10.455
3lshFADPyranose 2-oxidase/0.455
3o0iP54Heat shock protein HSP 90-alpha/0.455
4ek1CAMCamphor 5-monooxygenase1.14.15.10.455
4h9614QDihydrofolate reductase1.5.1.30.455
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
4o0uADNAurora kinase A2.7.11.10.455
1adfTADAlcohol dehydrogenase E chain1.1.1.10.454
1ie4T44Transthyretin/0.454
1knuYPAPeroxisome proliferator-activated receptor gamma/0.454
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.454
1rfvADPPyridoxal kinase2.7.1.350.454
2d29FADAcyl-CoA dehydrogenase/0.454
2jfaRALEstrogen receptor/0.454
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.454
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.454
4dgnLU2Casein kinase II subunit alpha2.7.11.10.454
4kb81QOCasein kinase I isoform delta2.7.11.10.454
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.454
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.454
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.454
5dt4ATPAurora kinase A2.7.11.10.454
1drbMTXDihydrofolate reductase1.5.1.30.453
1k6tXN1Gag-Pol polyprotein3.4.23.160.453
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
1m78NDPDihydrofolate reductase1.5.1.30.453
2aclREARetinoic acid receptor RXR-alpha/0.453
2bxe1FLSerum albumin/0.453
2p33J07Mitogen-activated protein kinase 102.7.11.240.453
2qe4JJ3Estrogen receptor/0.453
2qo9ANPEphrin type-A receptor 32.7.10.10.453
2rcyNAPPyrroline-5-carboxylate reductase/0.453
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.453
3dolGWIPol protein/0.453
3eptFDAPutative FAD-monooxygenase/0.453
3lsiFADPyranose 2-oxidase/0.453
3pj8404Cyclin-dependent kinase 22.7.11.220.453
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.453
3zewSTUEphrin type-B receptor 42.7.10.10.453
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.453
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.453
4jhz1KVBeta-glucuronidase3.2.1.310.453
4lfiGNPCasein kinase II subunit alpha2.7.11.10.453
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.453
4zm6ACON-acetyl-beta-D glucosaminidase/0.453
5itzLOCTubulin beta-2B chain/0.453
1jq5NADGlycerol dehydrogenase1.1.1.60.452
1qvnFRIInterleukin-2/0.452
1s19MC9Vitamin D3 receptor/0.452
2emuSAHDiphthine synthase/0.452
2j0m4STFocal adhesion kinase 12.7.10.20.452
2ykiYKIHeat shock protein HSP 90-alpha/0.452
2zdt46CMitogen-activated protein kinase 102.7.11.240.452
3cukFADD-amino-acid oxidase1.4.3.30.452
3gbuATPUncharacterized sugar kinase PH14592.7.10.452
3lfcZ86Mitogen-activated protein kinase 14/0.452
3uvqFS8Mitogen-activated protein kinase 14/0.452
3vrwYS5Vitamin D3 receptor/0.452
4c9pCAMCytochrome P450/0.452
4egnTWOCytochrome P450/0.452
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.452
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.452
4jx1CAMCamphor 5-monooxygenase1.14.15.10.452
4xivACPChemotaxis protein CheA2.7.13.30.452
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
1fm7DFVChalcone--flavonone isomerase 15.5.1.60.451
1g4tFTPThiamine-phosphate synthase/0.451
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.451
2ph5NADHomospermidine synthase/0.451
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
2uxoTACHTH-type transcriptional regulator TtgR/0.451
2xvw9NRSerum albumin/0.451
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.451
3a14NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.451
3cgfJNFMitogen-activated protein kinase 102.7.11.240.451
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
3iok1P6Tyrosine-protein kinase JAK2/0.451
3p3zP3ZPutative cytochrome P450/0.451
3pe2E1BCasein kinase II subunit alpha2.7.11.10.451
3vs3VSETyrosine-protein kinase HCK2.7.10.20.451
3w0yDS4Vitamin D3 receptor/0.451
3zh8C58Protein kinase C iota type2.7.11.130.451
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.451
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
4g2fC07Ephrin type-A receptor 32.7.10.10.451
4gk3L87Ephrin type-A receptor 32.7.10.10.451
4i8vBHFCytochrome P450 1A11.14.14.10.451
4xldBRLPeroxisome proliferator-activated receptor gamma/0.451
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
1a8pFADFerredoxin--NADP reductase/0.450
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.450
1rw8580TGF-beta receptor type-12.7.11.300.450
1uy9PU6Heat shock protein HSP 90-alpha/0.450
1zrqFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.450
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.450
2itnANPEpidermal growth factor receptor2.7.10.10.450
2vx07X7Ephrin type-B receptor 42.7.10.10.450
2w9hTOPDihydrofolate reductase1.5.1.30.450
2xx91NFGlutamate receptor 2/0.450
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.450
3fhxPXLPyridoxal kinase2.7.1.350.450
3gxlQIGTGF-beta receptor type-12.7.11.300.450
3nwq2NCGag-Pol polyprotein3.4.23.160.450
3vrtYS2Vitamin D3 receptor/0.450
3zhsTD6Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.450
4c58824Cyclin-G-associated kinase2.7.11.10.450
4ly91YYGlucokinase regulatory protein/0.450
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.450
4o2bLOCTubulin beta-2B chain/0.450
4wucANPDNA gyrase subunit B/0.450
4z07PCGcGMP-dependent protein kinase 12.7.11.120.450
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.450
5hs1VORLanosterol 14-alpha demethylase/0.450
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1jioDEB6-deoxyerythronolide B hydroxylase/0.449
1ojtFADDihydrolipoyl dehydrogenase/0.449
1qnfFADDeoxyribodipyrimidine photo-lyase4.1.99.30.449
2cgpCMPcAMP-activated global transcriptional regulator CRP/0.449
2cy0NAPShikimate dehydrogenase (NADP(+))/0.449
2iw84SPCyclin-dependent kinase 22.7.11.220.449
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.449
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.449
2xpuTDCTetracycline repressor protein class D/0.449
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.449
3a1nNADNDP-sugar epimerase/0.449
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.449
3imeBZ2Pantothenate synthetase6.3.2.10.449
3inxJZCHeat shock protein HSP 90-alpha/0.449
3iqfE4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.449
3my5RFZCyclin-dependent kinase 22.7.11.220.449
3t2zFADSulfide-quinone reductase/0.449
3vn2TLSPeroxisome proliferator-activated receptor gamma/0.449
3vspEK8Peroxisome proliferator-activated receptor gamma/0.449
4a4vYFDPeroxisome proliferator-activated receptor gamma/0.449
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.449
4hee14RPeroxisome proliferator-activated receptor gamma/0.449
4jx1CAHCamphor 5-monooxygenase1.14.15.10.449
4nyw2O3CREB-binding protein/0.449
4yswFADXanthine dehydrogenase/oxidase/0.449
5eypLOCTubulin beta chain/0.449
1l4mNCNNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.448
1pxmCK5Cyclin-dependent kinase 22.7.11.220.448
1uy6PU3Heat shock protein HSP 90-alpha/0.448
1yreCOAUncharacterized protein/0.448
2bunFADAppA protein/0.448
2npnSAMPutative cobalamin synthesis related protein/0.448
2ou2ACOHistone acetyltransferase KAT5/0.448
2znnS44Peroxisome proliferator-activated receptor alpha/0.448
2znq401Peroxisome proliferator-activated receptor delta/0.448
3ddqRRCCyclin-dependent kinase 22.7.11.220.448
3hz5Z64Heat shock protein HSP 90-alpha/0.448
4c57FEFCyclin-G-associated kinase2.7.11.10.448
4cd2FOLDihydrofolate reductase1.5.1.30.448
4eh60ONMitogen-activated protein kinase 14/0.448
4i2q1BTGag-Pol polyprotein2.7.7.490.448
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.448
4l9kEHFSerum albumin/0.448
4zs2FLUAlpha-ketoglutarate-dependent dioxygenase FTO/0.448
5a3cNADSIR2 family protein/0.448
1ee0CAA2-pyrone synthase/0.447
1gii1PUCyclin-dependent kinase 22.7.11.220.447
1uykPUXHeat shock protein HSP 90-alpha/0.447
1xny191Propionyl-CoA carboxylase complex B subunit/0.447
2cppCAMCamphor 5-monooxygenase1.14.15.10.447
2d3mCOA5,7-dihydroxy-2-methylchromone synthase2.3.1.2160.447
2i3gNAPN-acetyl-gamma-glutamyl-phosphate reductase1.2.1.380.447
2p4yC03Peroxisome proliferator-activated receptor gamma/0.447
2pciSAHDiphthine synthase/0.447
2q70DC8Estrogen receptor/0.447
2qhzMZ2Gag-Pol polyprotein/0.447
2vbdV10Isopenicillin N synthase1.21.3.10.447
2vx17X8Ephrin type-B receptor 42.7.10.10.447
3dmjGWEPol protein/0.447
3lf0ATPNitrogen regulatory protein P-II/0.447
3lu8IQXSerum albumin/0.447
3mnrSD1Heat shock protein HSP 90-alpha/0.447
3sa8K83Protease/0.447
3t14FADSulfide-quinone reductase/0.447
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.447
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.447
3w4yFADMitochondrial FAD-linked sulfhydryl oxidase ERV11.8.3.20.447
4b13NHWGlycylpeptide N-tetradecanoyltransferase/0.447
4f9mFCMPeroxisome proliferator-activated receptor gamma/0.447
4gfg0XFTyrosine-protein kinase SYK2.7.10.20.447
4ix6ADPUncharacterized protein/0.447
4kbc1QJCasein kinase I isoform delta2.7.11.10.447
4q1y017Gag-Pol polyprotein3.4.23.160.447
4qknJMSAlpha-ketoglutarate-dependent dioxygenase FTO/0.447
4x2dATPFic family protein putative filamentation induced by cAMP protein/0.447
5fbhTCRExtracellular calcium-sensing receptor/0.447
5ii2LU2Protein polybromo-1/0.447
1blzACVIsopenicillin N synthase1.21.3.10.446
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.446
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.446
1e8xATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
1iwjCAMCamphor 5-monooxygenase1.14.15.10.446
1k6mAGS6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 12.7.1.1050.446
1m2pHNACasein kinase II subunit alpha2.7.11.10.446
1v9aSAHUncharacterized protein/0.446
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
1yw2PGJMitogen-activated protein kinase 14/0.446
2dvlFADAcyl-CoA dehydrogenase/0.446
2dwbANPAurora kinase A2.7.11.10.446
2iviACWIsopenicillin N synthase1.21.3.10.446
2w0bCMWLanosterol 14-alpha demethylase1.14.13.700.446
2wd9IBPAcyl-coenzyme A synthetase ACSM2A, mitochondrial6.2.1.20.446
2xvdAS6Ephrin type-B receptor 42.7.10.10.446
2yneNHWGlycylpeptide N-tetradecanoyltransferase/0.446
2znpK55Peroxisome proliferator-activated receptor delta/0.446
3fywXCFDihydrofolate reductase1.5.1.30.446
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.446
3lu7IPXSerum albumin/0.446
3ocpCMPcGMP-dependent protein kinase 12.7.11.120.446
3rnnRNNGlutamate receptor 2/0.446
3tw6ADPPyruvate carboxylase/0.446
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.446
4b10NHWGlycylpeptide N-tetradecanoyltransferase/0.446
4dpwAGSMevalonate diphosphate decarboxylase/0.446
4h6rFDAProline dehydrogenase/0.446
4jbqVX6Aurora kinase A2.7.11.10.446
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.446
4y8wSTRSteroid 21-hydroxylase/0.446
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.446
5cshATPCasein kinase II subunit alpha2.7.11.10.446
5dnrATPAurora kinase A2.7.11.10.446
5dosATPAurora kinase A2.7.11.10.446
1nvtNAPShikimate dehydrogenase (NADP(+))/0.445
1oirHDYCyclin-dependent kinase 22.7.11.220.445
1udyFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.445
1upw444Oxysterols receptor LXR-beta/0.445
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.445
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.445
2izrBRKCasein kinase I isoform gamma-32.7.11.10.445
2p2qPRXAcetyl-coenzyme A synthetase/0.445
2q5p241Peroxisome proliferator-activated receptor gamma/0.445
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.445
2v7a627Tyrosine-protein kinase ABL12.7.10.20.445
2y5s78HDihydropteroate synthase/0.445
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.445
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.445
3cs8BRLPeroxisome proliferator-activated receptor gamma/0.445
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.445
3h3sH15Collagen type IV alpha-3-binding protein/0.445
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.445
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.445
3pe6ZYHMonoglyceride lipase/0.445
3r9uFADThioredoxin reductase/0.445
3rak03ZCyclin-dependent kinase 22.7.11.220.445
3rusADPChaperonin/0.445
3rvg17PTyrosine-protein kinase JAK2/0.445
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.445
3tk3CPZCytochrome P450 2B41.14.14.10.445
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
4i02CMPcAMP-activated global transcriptional regulator CRP/0.445
4inb1F6Gag protein/0.445
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.445
4r81FMNPredicted NADH dehydrogenase/0.445
5a27MYAGlycylpeptide N-tetradecanoyltransferase/0.445
1errRALEstrogen receptor/0.444
1kzjCB3Thymidylate synthase/0.444
1lsoNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.444
1rfuADPPyridoxal kinase2.7.1.350.444
1suoCPZCytochrome P450 2B41.14.14.10.444
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
1txiTX5Vitamin D3 receptor/0.444
1u54ACPActivated CDC42 kinase 1/0.444
1uyfPU1Heat shock protein HSP 90-alpha/0.444
1v59FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.444
1yrcCAMCamphor 5-monooxygenase1.14.15.10.444
1zdwFLVPrenyltransferase/0.444
1zeoC01Peroxisome proliferator-activated receptor gamma/0.444
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.444
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.444
2hk51BMTyrosine-protein kinase HCK2.7.10.20.444
2ijmATPFocal adhesion kinase 12.7.10.20.444
2itpAEEEpidermal growth factor receptor2.7.10.10.444
2izuP01Casein kinase I isoform gamma-32.7.11.10.444
2ovmAS0Progesterone receptor/0.444
2vr1ATFBiotin carboxylase6.3.4.140.444
2w2lNADD-mandelate dehydrogenase/0.444
2xneASHAurora kinase A2.7.11.10.444
2y6fM9FIsopenicillin N synthase1.21.3.10.444
2zbaZBATrichothecene 3-O-acetyltransferase/0.444
3eigMTXDihydrofolate reductase1.5.1.30.444
3gfbNADL-threonine 3-dehydrogenase/0.444
3gggNADPrephenate dehydrogenase/0.444
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.444
3nl6TPSUncharacterized protein/0.444
3qlwN22Dihydrofolate reductase1.5.1.30.444
3qm4PN0Cytochrome P450 2D6/0.444
3rm618ZCyclin-dependent kinase 22.7.11.220.444
3tea4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.444
3tvuB37Acetyl-CoA carboxylase/0.444
3upf0BUPolyprotein/0.444
3uyt0CKCasein kinase I isoform delta2.7.11.10.444
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.444
4bcmT7ZCyclin-dependent kinase 22.7.11.220.444
4c02TAKActivin receptor type-12.7.11.300.444
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.444
4em9TCEPeroxisome proliferator-activated receptor gamma/0.444
4fod0UVALK tyrosine kinase receptor2.7.10.10.444
4gk2L66Ephrin type-A receptor 32.7.10.10.444
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.444
4mv8ACPBiotin carboxylase6.3.4.140.444
1bifAGS6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 42.7.1.1050.443
1i3mUD1UDP-glucose 4-epimerase/0.443
1ie8KH1Vitamin D3 receptor/0.443
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1iqrFADDeoxyribodipyrimidine photo-lyase4.1.99.30.443
1o76CAMCamphor 5-monooxygenase1.14.15.10.443
1sn0T44Transthyretin/0.443
1tl7FOKAdenylate cyclase type 2/0.443
1tl7FOKAdenylate cyclase type 5/0.443
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.443
2bgiFADNADPH:ferredoxin reductase/0.443
2c27ACOMycothiol acetyltransferase2.3.1.1890.443
2fwyH64Heat shock protein HSP 90-alpha/0.443
2iw94SPCyclin-dependent kinase 22.7.11.220.443
2j14GNIPeroxisome proliferator-activated receptor delta/0.443
2p20PRXAcetyl-coenzyme A synthetase/0.443
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.443
2qi6MZ8Gag-Pol polyprotein/0.443
2vwu7X1Ephrin type-B receptor 42.7.10.10.443
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.443
3el4ROCGag-Pol polyprotein3.4.23.160.443
3i0rRT3Gag-Pol polyprotein2.7.7.490.443
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.443
3vt5YI2Vitamin D3 receptor/0.443
3wd7COAAcridone synthase/0.443
3wdlATP4-phosphopantoate--beta-alanine ligase6.3.2.360.443
3zhrTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.443
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.443
4eiyZMAAdenosine receptor A2a/0.443
4g3jVNTLanosterol 14-alpha-demethylase/0.443
4h3zSAHtRNA (guanine-N(1)-)-methyltransferase/0.443
4hxyNDPPlm1/0.443
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.443
4i22IREEpidermal growth factor receptor2.7.10.10.443
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.443
4l4dCAMCamphor 5-monooxygenase1.14.15.10.443
4n6bCOAUncharacterized protein/0.443
4nh82LCHeat shock protein HSP 90-alpha/0.443
4prxADPDNA gyrase subunit B/0.443
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.443
4y93746Tyrosine-protein kinase/0.443
1dhrNADDihydropteridine reductase1.5.1.340.442
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.442
1yonA2R2-dehydropantoate 2-reductase1.1.1.1690.442
1zgyBRLPeroxisome proliferator-activated receptor gamma/0.442
2h96893Mitogen-activated protein kinase 82.7.11.240.442
2jf9OHTEstrogen receptor/0.442
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.442
2qi3MZ5Gag-Pol polyprotein/0.442
2rkvZBATrichothecene 3-O-acetyltransferase/0.442
2ykcYKCHeat shock protein HSP 90-alpha/0.442
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.442
3bheBZNGag-Pol polyprotein3.4.23.160.442
3crzFADFerredoxin--NADP+ reductase/0.442
3em6017Gag-Pol polyprotein3.4.23.160.442
3gbk2PQPeroxisome proliferator-activated receptor gamma/0.442
3oriAGSSerine/threonine protein kinase/0.442
3q9xEMOCasein kinase II subunit alpha2.7.11.10.442
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.442
3vev0H4Glucokinase2.7.1.20.442
3vthAPCCarbamoyltransferase/0.442
3w0pADPHygromycin-B 4-O-kinase2.7.1.1630.442
3zuxTCHTransporter/0.442
4elg52JDihydrofolate reductase/0.442
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.442
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4m10ICDProstaglandin G/H synthase 21.14.99.10.442
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.442
4tuvCPZCytochrome P450 1191.140.442
4wsqKSAAP2-associated protein kinase 12.7.11.10.442
5e8ySTUTGF-beta receptor type-22.7.11.300.442
1bk0ACVIsopenicillin N synthase1.21.3.10.441
1fmjRTLRetinol dehydratase/0.441
1rkhVD2Vitamin D3 receptor/0.441
1y0s331Peroxisome proliferator-activated receptor delta/0.441
2bfrADP[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.441
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.441
2d52COA5,7-dihydroxy-2-methylchromone synthase2.3.1.2160.441
2hamC33Vitamin D3 receptor/0.441
2hm9TRRDihydrofolate reductase1.5.1.30.441
2hw2RFPRifampin ADP-ribosyl transferase/0.441
2j0k4STFocal adhesion kinase 12.7.10.20.441
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
2qg2A91Heat shock protein HSP 90-alpha/0.441
2uxpCLMHTH-type transcriptional regulator TtgR/0.441
2vnhFADNADPH:ferredoxin reductase/0.441
2x0iNAIMalate dehydrogenase/0.441
2xa4AZ5Tyrosine-protein kinase JAK2/0.441
2xlsFADPutative flavin-containing monooxygenase/0.441
2xvv9DNSerum albumin/0.441
2zlaVDBVitamin D3 receptor/0.441
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.441
3fl8RARDihydrofolate reductase/0.441
3mqe416Prostaglandin G/H synthase 21.14.99.10.441
3nga3NGCasein kinase II subunit alpha2.7.11.10.441
3sqq99ZCyclin-dependent kinase 22.7.11.220.441
3t3r9PLCytochrome P450 2A61.14.130.441
3te4ACODopamine N-acetyltransferase/0.441
3vrvYSDVitamin D3 receptor/0.441
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.441
4ambDUDPutative glycosyl transferase/0.441
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4awp99AHeat shock protein HSP 90-alpha/0.441
4dymIYZActivin receptor type-12.7.11.300.441
4iteTEYVitamin D3 receptor/0.441
4iw8KN3Estrogen receptor/0.441
4kin1M8Mitogen-activated protein kinase 14/0.441
4l4aCAMCamphor 5-monooxygenase1.14.15.10.441
4xf7ACPCarbohydrate/pyrimidine kinase, PfkB family/0.441
4xiwAZMCarbonic anhydrase, alpha type/0.441
4xumIMNPeroxisome proliferator-activated receptor gamma/0.441
5auzGENDeath-associated protein kinase 12.7.11.10.441
5bsgNAPPyrroline-5-carboxylate reductase/0.441
5ikqJMSProstaglandin G/H synthase 21.14.99.10.441
1dhiMTXDihydrofolate reductase1.5.1.30.440
1draMTXDihydrofolate reductase1.5.1.30.440
1dz6CAMCamphor 5-monooxygenase1.14.15.10.440
1hb3SCVIsopenicillin N synthase1.21.3.10.440
1mjbACOHistone acetyltransferase ESA1/0.440
1okkGCPSignal recognition particle protein/0.440
1okkGCPSignal recognition particle receptor FtsY/0.440
1rx8FOLDihydrofolate reductase1.5.1.30.440
1uydPU8Heat shock protein HSP 90-alpha/0.440
1wsvTHHAminomethyltransferase, mitochondrial/0.440
2ath3EAPeroxisome proliferator-activated receptor gamma/0.440
2belCBOCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
2bfyH1NAurora kinase B-A2.7.11.10.440
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.440
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
2ebaFADPutative glutaryl-CoA dehydrogenase/0.440
2ghmLICMitogen-activated protein kinase 14/0.440
2ittAEEEpidermal growth factor receptor2.7.10.10.440
2nmtNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.440
2pcgSAHDiphthine synthase/0.440
2pmdGNPTranslation initiation factor 2 subunit gamma/0.440
2pvhP19Casein kinase II subunit alpha2.7.11.10.440
2vd5BI8Myotonin-protein kinase2.7.11.10.440
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.440
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.440
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.440
3iw1ASDSteroid C26-monooxygenase1.14.13.1410.440
3jskAHZThiamine thiazole synthase/0.440
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.440
3lfnA27Cyclin-dependent kinase 22.7.11.220.440
3lltANPProtein serine/threonine kinase-1/0.440
3lqfNADGalactitol dehydrogenase/0.440
3nux3NVCyclin-dependent kinase 62.7.11.220.440
3qaiXNNKetohexokinase/0.440
3s4qNK0Mitogen-activated protein kinase 14/0.440
3slkNDPPolyketide synthase extender module 2/0.440
3t1a5MAGag-Pol polyprotein2.7.7.490.440
3ttjJBIMitogen-activated protein kinase 102.7.11.240.440
3u9eCOALmo1369 protein/0.440
3vjoANPEpidermal growth factor receptor2.7.10.10.440
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.440
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.440
4g3rCAMCamphor 5-monooxygenase1.14.15.10.440
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.440
4gmy0X5Tyrosine-protein kinase JAK2/0.440
4iwv1J9Glucokinase2.7.1.20.440
4ktl1CQCytochrome P450/0.440
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.440
4u0mGTPCyclic GMP-AMP synthase/0.440
5dr6SKEAurora kinase A2.7.11.10.440
5e8xSTUTGF-beta receptor type-12.7.11.300.440