sc-PDB

List of CHEMBLId :

This value allows a number of roughly comparable measures of half-maximal response concentration/potency/affinity to be compared on a negative logarithmic scale (e.g., an IC50 measurement of 1nM would have a pChEMBL value of 9).

Uniprot Annotation

Name:	cGMP-dependent 3',5'-cyclic phosphodiesterase
ID:	PDE2A_HUMAN
AC:	O00408
Organism:	Homo sapiens
Reign:	Eukaryota
TaxID:	9606
EC Number:	3.1.4.17

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Chains:

Chain Name:	Percentage of Residues within binding site
B	15 %
C	85 %

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Ligand binding site composition:

B-Factor:	18.909
Number of residues:	37
Including
Standard Amino Acids:	32
Non Standard Amino Acids:	2
Water Molecules:	3
Cofactors:
Metals:	ZN MG

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Cavity properties

Ligandability	Volume (Å3)
0.633	1876.500

% Hydrophobic	% Polar
49.46	50.54
According to VolSite

HET Code:	1L6
Formula:	C23H28N6O2
Molecular weight:	420.507 g/mol
DrugBank ID:	-
Buried Surface Area:	55.81 %
Polar Surface area:	97.33 Å2

Number of
H-Bond Acceptors:	5
H-Bond Donors:	2
Rings:	4
Aromatic rings:	3
Anionic atoms:	0
Cationic atoms:	0
Rule of Five Violation:	0
Rotatable Bonds:	6

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Mass center Coordinates

X	Y	Z
36.601	32.0637	42.2268

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