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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2xk6EQHSerine/threonine-protein kinase Nek22.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2xk6EQHSerine/threonine-protein kinase Nek22.7.11.11.000
2xk3XK3Serine/threonine-protein kinase Nek22.7.11.10.706
2xk85R1Serine/threonine-protein kinase Nek22.7.11.10.647
2xnmWGZSerine/threonine-protein kinase Nek22.7.11.10.632
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.624
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.617
2wqoVGKSerine/threonine-protein kinase Nek22.7.11.10.609
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.600
2yac937Serine/threonine-protein kinase PLK12.7.11.210.600
4a4xJUPSerine/threonine-protein kinase Nek22.7.11.10.592
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.591
2xkc4VQSerine/threonine-protein kinase Nek22.7.11.10.589
4afeGGYSerine/threonine-protein kinase Nek22.7.11.10.587
2xk4OL2Serine/threonine-protein kinase Nek22.7.11.10.586
2xk730ESerine/threonine-protein kinase Nek22.7.11.10.574
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.572
2xnpWCXSerine/threonine-protein kinase Nek22.7.11.10.560
2xnoED8Serine/threonine-protein kinase Nek22.7.11.10.558
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.557
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.556
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.549
2w5bAGSSerine/threonine-protein kinase Nek22.7.11.10.547
2owb626Serine/threonine-protein kinase PLK12.7.11.210.545
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.544
3zkyWT4Isopenicillin N synthase1.21.3.10.542
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.531
4b6l9ZPSerine/threonine-protein kinase PLK32.7.11.210.528
2in6839Wee1-like protein kinase2.7.10.20.525
1pq944BOxysterols receptor LXR-beta/0.523
4bb3KKAIsopenicillin N synthase1.21.3.10.522
2vcmM11Isopenicillin N synthase1.21.3.10.518
4iwv1J9Glucokinase2.7.1.20.518
2jb4A14Isopenicillin N synthase1.21.3.10.514
2xnn430Serine/threonine-protein kinase Nek22.7.11.10.512
2z2w770Wee1-like protein kinase2.7.10.20.512
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.511
1qiqACCIsopenicillin N synthase1.21.3.10.509
2io6330Wee1-like protein kinase2.7.10.20.509
1bk0ACVIsopenicillin N synthase1.21.3.10.507
1w06W05Isopenicillin N synthase1.21.3.10.507
3pqbVGPPutative oxidoreductase/0.505
1obnASVIsopenicillin N synthase1.21.3.10.504
1qjfACSIsopenicillin N synthase1.21.3.10.504
2ejzSAHDiphthine synthase/0.503
2vbpVB1Isopenicillin N synthase1.21.3.10.502
1pqc444Oxysterols receptor LXR-beta/0.501
2uvyGVIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.501
3cr0809Wee1-like protein kinase2.7.10.20.500
1hb3SCVIsopenicillin N synthase1.21.3.10.499
2y60M8FIsopenicillin N synthase1.21.3.10.499
1x8b824Wee1-like protein kinase2.7.10.20.498
2zrzFNRIsopentenyl-diphosphate delta-isomerase/0.498
3zoiM2WIsopenicillin N synthase1.21.3.10.498
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.498
4xulGTPUncharacterized protein mg662/0.498
1hb1OCVIsopenicillin N synthase1.21.3.10.497
1uzwCDHIsopenicillin N synthase1.21.3.10.496
2x23TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.496
2zrvFNRIsopentenyl-diphosphate delta-isomerase/0.496
3bi6396Wee1-like protein kinase2.7.10.20.496
3qv1NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic1.2.1.130.496
4at4T6EBDNF/NT-3 growth factors receptor2.7.10.10.496
4pl9ADPEthylene receptor 1/0.496
1odjGMPPurine nucleoside phosphorylase/0.495
2wo7ASVIsopenicillin N synthase1.21.3.10.495
3d5wADPSerine/threonine-protein kinase PLK/0.495
3eta351Insulin receptor2.7.10.10.495
4fnyI3KALK tyrosine kinase receptor2.7.10.10.494
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.494
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.493
3h3r14HCollagen type IV alpha-3-binding protein/0.493
4jauADPSensor histidine kinase/0.493
5dozNDPJamJ/0.492
1fm7DFVChalcone--flavonone isomerase 15.5.1.60.491
2a9z26AAdenosine kinase2.7.1.200.491
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.491
2zsdCOAPantothenate kinase2.7.1.330.491
3ihgVAKAklavinone 12-hydroxylase RdmE/0.491
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.490
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.490
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.490
2ed3SAHDiphthine synthase/0.489
2iviACWIsopenicillin N synthase1.21.3.10.489
2xtbKRMAdenosine kinase, putative/0.489
2zruFMNIsopentenyl-diphosphate delta-isomerase/0.489
1d3dBZTProthrombin3.4.21.50.488
3htjETEbrA repressor/0.488
3zkuHCVIsopenicillin N synthase1.21.3.10.488
4dvi2IWTankyrase-12.4.2.300.488
1blzACVIsopenicillin N synthase1.21.3.10.487
2z4sADPChromosomal replication initiator protein DnaA/0.487
3b04OOPIsopentenyl-diphosphate delta-isomerase/0.487
3ebiBEYM1 family aminopeptidase3.4.110.487
3qm4PN0Cytochrome P450 2D6/0.487
4fevPP1Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.487
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.486
2bu9HFVIsopenicillin N synthase1.21.3.10.486
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.486
4bfwZVWPantothenate kinase2.7.1.330.486
4qmwKS1Serine/threonine-protein kinase 242.7.11.10.486
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.484
2b378PSEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.484
1oc1ASVIsopenicillin N synthase1.21.3.10.483
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.483
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.483
5dp2NAPCurF/0.483
2vbdV10Isopenicillin N synthase1.21.3.10.482
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.482
1qoqIGPTryptophan synthase alpha chain/0.481
1toiHCIAspartate aminotransferase2.6.1.10.481
1z71L17Prothrombin3.4.21.50.481
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.481
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.481
2ydoADNAdenosine receptor A2a/0.481
4wctFADFructosyl amine:oxygen oxidoreductase/0.481
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.480
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.480
3adaNADSubunit alpha of sarocosine oxidase/0.480
3gkjHC3Niemann-Pick C1 protein/0.480
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.480
4nt3ZAWLactoperoxidase1.11.1.70.480
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.480
5g53NECAdenosine receptor A2a/0.480
2wbaFADTrypanothione reductase1.8.1.120.479
2x06NADL-sulfolactate dehydrogenase/0.479
3p6nDSOCamphor 5-monooxygenase1.14.15.10.479
4phlPILPhosphodiesterase/0.479
5ej4TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.479
1odnAPVIsopenicillin N synthase1.21.3.10.478
1rgsCMPcAMP-dependent protein kinase type I-alpha regulatory subunit/0.478
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.478
2w5aADPSerine/threonine-protein kinase Nek22.7.11.10.478
3kr6UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.478
3oct1N1Tyrosine-protein kinase BTK2.7.10.20.478
4n3l2FNProthrombin3.4.21.50.478
2jh0701Prothrombin3.4.21.50.477
2y6fM9FIsopenicillin N synthase1.21.3.10.477
2ywvADPPhosphoribosylaminoimidazole-succinocarboxamide synthase/0.477
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.477
4gutFADLysine-specific histone demethylase 1B10.477
4h6zACOAlpha-tubulin N-acetyltransferase 1/0.477
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.476
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.476
4lv8ADPRhoptry protein 5 C/0.476
4twnB96Ephrin type-A receptor 32.7.10.10.476
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.475
3h1vTK1Glucokinase2.7.1.20.475
4b66NAPL-ornithine N(5)-monooxygenase/0.475
4jva1ORcAMP-dependent protein kinase type II-beta regulatory subunit/0.475
1cbrREACellular retinoic acid-binding protein 1/0.474
1d3pBT3Prothrombin3.4.21.50.474
1jxzBCA4-chlorobenzoyl coenzyme A dehalogenase3.8.1.70.474
2gesCOKPantothenate kinase2.7.1.330.474
3bloQEIQueuine tRNA-ribosyltransferase2.4.2.290.474
3qe2FMNNADPH--cytochrome P450 reductase/0.474
4imfSI3N-acetylneuraminate lyase/0.474
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.474
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.474
1wuuANPGalactokinase2.7.1.60.473
2vcwZZAHematopoietic prostaglandin D synthase/0.473
3cqeP91Wee1-like protein kinase2.7.10.20.473
3fvqATPFe(3+) ions import ATP-binding protein FbpC/0.473
3qri919Tyrosine-protein kinase ABL12.7.10.20.473
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.473
4jlj1NMDeoxycytidine kinase2.7.1.740.473
7catNDPCatalase1.11.1.60.473
1u1d181Uridine phosphorylase2.4.2.30.472
1xf0ASDAldo-keto reductase family 1 member C3/0.472
1ypeUIPProthrombin3.4.21.50.472
2vdmAGGIntegrin alpha-IIb/0.472
2vdmAGGIntegrin beta-3/0.472
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.472
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.472
3s41S41Glucokinase2.7.1.20.472
4dk70KSOxysterols receptor LXR-beta/0.472
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.472
1d6w00RProthrombin3.4.21.50.471
2oliIOPBasic phospholipase A2 VRV-PL-VIIIa3.1.1.40.471
3ctj320Hepatocyte growth factor receptor2.7.10.10.471
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.471
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.471
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.471
3q44D50M1 family aminopeptidase3.4.110.471
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.471
4b4vL34Bifunctional protein FolD/0.471
4fgrADPPhosphoribosylaminoimidazole-succinocarboxamide synthase6.3.2.60.471
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.471
1euyQSIGlutamine--tRNA ligase6.1.1.180.470
1wp4NDP3-hydroxyisobutyrate dehydrogenase/0.470
2du8FADD-amino-acid oxidase1.4.3.30.470
2j9lATPH(+)/Cl(-) exchange transporter 5/0.470
2jav5Z5Serine/threonine-protein kinase Nek22.7.11.10.470
3e5aVX6Aurora kinase A2.7.11.10.470
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
4dlbNADS-(hydroxymethyl)glutathione dehydrogenase/0.470
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.470
4j6cSTRCytochrome P450 monooxygenase/0.470
5k2aZMAAdenosine receptor A2a/0.470
3emlZMAAdenosine receptor A2a/0.470
1akbPPDAspartate aminotransferase, mitochondrial2.6.1.10.469
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.469
1oj4CDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.469
1uhlMEIRetinoic acid receptor RXR-beta/0.469
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.469
2gq3COAMalate synthase G/0.469
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.469
2j83BATUlilysin3.4.240.469
2vczVC3Hematopoietic prostaglandin D synthase/0.469
3dh7FMNIsopentenyl-diphosphate delta-isomerase/0.469
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.469
3iw8HIZMitogen-activated protein kinase 14/0.469
4b4w9L9Bifunctional protein FolD/0.469
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.469
5k2cZMAAdenosine receptor A2a/0.469
1k4gAIQQueuine tRNA-ribosyltransferase2.4.2.290.468
2pbwDOQGlutamate receptor ionotropic, kainate 1/0.468
2w6pOA4Biotin carboxylase6.3.4.140.468
3arvSAUChitinase A/0.468
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.468
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.468
4htx19FcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.468
4pxzCLRP2Y purinoceptor 12/0.468
1gxfFADTrypanothione reductase1.8.1.120.467
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
1mvsDTMDihydrofolate reductase1.5.1.30.467
1t57FMNConserved protein/0.467
1w1wAGSStructural maintenance of chromosomes protein 1/0.467
1x1cSAHC-20 methyltransferase/0.467
3zeiAWHO-acetylserine sulfhydrylase/0.467
4klrCHDFerrochelatase, mitochondrial4.99.1.10.467
4l3q926Glucokinase2.7.1.20.467
4pmjNAPPutative oxidoreductase/0.467
1g63FMNEpidermin decarboxylase4.1.10.466
2bakAQZMitogen-activated protein kinase 14/0.466
2gevCOKPantothenate kinase2.7.1.330.466
2po7CHDFerrochelatase, mitochondrial4.99.1.10.466
2rc6NAPFerredoxin--NADP reductase/0.466
3cth319Hepatocyte growth factor receptor2.7.10.10.466
3gkiCLRNiemann-Pick C1 protein/0.466
3t5iSER_SER_CMT_FARRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.466
3zk6H1IBcl-2-like protein 1/0.466
4a2aATPCell division protein FtsA/0.466
4a9yAQZMitogen-activated protein kinase 14/0.466
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.466
4b99R4LMitogen-activated protein kinase 72.7.11.240.466
4bkjSTIEpithelial discoidin domain-containing receptor 12.7.10.10.466
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.466
4j6dTESCytochrome P450 monooxygenase/0.466
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.466
5k2bZMAAdenosine receptor A2a/0.466
1diuBDMDihydrofolate reductase1.5.1.30.465
1nm6L86Prothrombin3.4.21.50.465
1u1gBBBUridine phosphorylase2.4.2.30.465
1x1bSAHC-20 methyltransferase/0.465
2b01TUDPhospholipase A2, major isoenzyme3.1.1.40.465
3d7zGK5Mitogen-activated protein kinase 14/0.465
3djlFADPutative acyl-CoA dehydrogenase AidB1.3.990.465
3q9bB3NAcetylpolyamine amidohydrolase/0.465
3vf60H6Glucokinase2.7.1.20.465
4bfxZVXPantothenate kinase2.7.1.330.465
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
4djw0KPBeta-secretase 13.4.23.460.465
4stdBFSScytalone dehydratase4.2.1.940.465
1xm1GAHProthrombin3.4.21.50.464
2cn0F25Prothrombin3.4.21.50.464
2ekaSAHDiphthine synthase/0.464
2g78REACellular retinoic acid-binding protein 2/0.464
2i4tUA2Purine nucleoside phosphorylase, putative/0.464
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.464
2pksG44Prothrombin3.4.21.50.464
3dgeADPSensor histidine kinase/0.464
3gc4AAQQueuine tRNA-ribosyltransferase2.4.2.290.464
3lfeZ84Mitogen-activated protein kinase 14/0.464
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.464
4k38SAMAnaerobic sulfatase-maturating enzyme1.8.980.464
4rn615UProthrombin3.4.21.50.464
4ubvCOASteroid 3-ketoacyl-CoA thiolase/0.464
5jtbZMAAdenosine receptor A2a/0.464
1uwhBAXSerine/threonine-protein kinase B-raf2.7.11.10.463
1w83L11Mitogen-activated protein kinase 14/0.463
1zdwFLVPrenyltransferase/0.463
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.463
2pdaTPPPyruvate synthase/0.463
2zevIPEGeranylgeranyl pyrophosphate synthase/0.463
3dtcVINMitogen-activated protein kinase kinase kinase 92.7.11.250.463
3eigMTXDihydrofolate reductase1.5.1.30.463
3fhxPXLPyridoxal kinase2.7.1.350.463
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.463
3hub469Mitogen-activated protein kinase 14/0.463
3jynNDPQuinone oxidoreductase/0.463
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.463
4g95OAGDihydrofolate reductase1.5.1.30.463
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.463
5f8uP32Beta-1 adrenergic receptor/0.463
1kruIPTGalactoside O-acetyltransferase2.3.1.180.462
1u1cBAUUridine phosphorylase2.4.2.30.462
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.462
1z4iUMP5'(3')-deoxyribonucleotidase, mitochondrial3.1.30.462
2bjsACVIsopenicillin N synthase1.21.3.10.462
2p1t3TNRetinoic acid receptor RXR-alpha/0.462
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.462
2w6oOA3Biotin carboxylase6.3.4.140.462
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.462
3b05FNRIsopentenyl-diphosphate delta-isomerase/0.462
3cgyRDCVirulence sensor histidine kinase PhoQ2.7.13.30.462
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.462
3ql3FOLDihydrofolate reductase1.5.1.30.462
3rsv3RSBeta-secretase 13.4.23.460.462
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.462
3zsh469Mitogen-activated protein kinase 14/0.462
4dbs0HVAldo-keto reductase family 1 member C3/0.462
4elb34RDihydrofolate reductase/0.462
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.462
4gs4ACOAlpha-tubulin N-acetyltransferase 1/0.462
4iae1DXAlr2278 protein/0.462
4kfj1R0Dihydrofolate reductase1.5.1.30.462
4ocvANPAminoglycoside phosphotransferase/0.462
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.462
1swtBTNStreptavidin/0.461
1x1dSAHC-20 methyltransferase/0.461
1yhjR6CPyridoxal kinase2.7.1.350.461
2p1u4TNRetinoic acid receptor RXR-alpha/0.461
2wksCB63-dehydroquinate dehydratase4.2.1.100.461
2zevB71Geranylgeranyl pyrophosphate synthase/0.461
3h4vDVPPteridine reductase 11.5.1.330.461
3qwbNDPProbable quinone oxidoreductase1.6.5.50.461
3tneRITCandidapepsin-13.4.23.240.461
4g47TZFMycocyclosin synthase1.14.21.90.461
4guuFA9Lysine-specific histone demethylase 1B10.461
4jlk1NODeoxycytidine kinase2.7.1.740.461
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.461
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.460
1jpaANPEphrin type-B receptor 22.7.10.10.460
1kqwRTLCellular retinol-binding protein type II/0.460
1ne6SP1cAMP-dependent protein kinase type I-alpha regulatory subunit/0.460
1t4v14AProthrombin3.4.21.50.460
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
2pckSAHDiphthine synthase/0.460
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.460
3gf4U5PUDP-galactopyranose mutase5.4.99.90.460
3gqzGF7Beta-lactamase3.5.2.60.460
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
4du6GTPGTP cyclohydrolase 1/0.460
1k4hAPQQueuine tRNA-ribosyltransferase2.4.2.290.459
1nqvLMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.459
1p8dCO1Oxysterols receptor LXR-beta/0.459
1ta6177Prothrombin3.4.21.50.459
1tojHCIAspartate aminotransferase2.6.1.10.459
1zzlTZYMitogen-activated protein kinase 14/0.459
2a19ANPInterferon-induced, double-stranded RNA-activated protein kinase2.7.11.10.459
2clfF6FTryptophan synthase alpha chain/0.459
2fhjMFNFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.459
2fzwNADAlcohol dehydrogenase class-31.1.1.10.459
2uuk897Prothrombin3.4.21.50.459
3ewsADPATP-dependent RNA helicase DDX19B3.6.4.130.459
3fkoFKOMitogen-activated protein kinase 14/0.459
3rtnRTNBeta-secretase 13.4.23.460.459
3slkNDPPolyketide synthase extender module 2/0.459
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.459
4jlm1NNDeoxycytidine kinase2.7.1.740.459
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.459
5c7hNDPPutative oxidoreductase/0.459
1oytFSNProthrombin3.4.21.50.458
1v5z2HCMajor NAD(P)H-flavin oxidoreductase1.6.990.458
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.458
2culFADGidA-related protein/0.458
2dhfDZFDihydrofolate reductase1.5.1.30.458
2eeqSAHDiphthine synthase/0.458
2g274LGRenin3.4.23.150.458
2r2mI50Prothrombin3.4.21.50.458
3ar6TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.458
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
3ekuCY9Actin-5C/0.458
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.458
4dhyS41Glucokinase2.7.1.20.458
4n82FMNRibonucleotide reductase (NrdI family protein), putative/0.458
4x5jFOLDihydrofolate reductase1.5.1.30.458
1dhfFOLDihydrofolate reductase1.5.1.30.457
1jdzFMBPurine nucleoside phosphorylase/0.457
1n5vNOMActVA 6 protein/0.457
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.457
2bt4CA23-dehydroquinate dehydratase4.2.1.100.457
2cjfRP43-dehydroquinate dehydratase4.2.1.100.457
2geuCOKPantothenate kinase2.7.1.330.457
2gtbAZPOrf1ab polyprotein/0.457
2hm9TRRDihydrofolate reductase1.5.1.30.457
2owfSAHDiphthine synthase/0.457
2p2xSAHDiphthine synthase/0.457
2qw8NAPEugenol synthase 11.1.1.3180.457
2v3oI26Prothrombin3.4.21.50.457
2zb8IMNProstaglandin reductase 21.3.1.480.457
3biz61EWee1-like protein kinase2.7.10.20.457
3d4bDZDNAD-dependent protein deacetylase/0.457
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
3ox4NADAlcohol dehydrogenase 21.1.1.10.457
3p0fBAUUridine phosphorylase 22.4.2.30.457
3pdnSFGHistone-lysine N-methyltransferase SMYD32.1.1.430.457
3q3cNADNAD-dependent L-serine dehydrogenase/0.457
3ukoNADAlcohol dehydrogenase class-3/0.457
3zu2NAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.457
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.457
4bfvZVVPantothenate kinase2.7.1.330.457
4da6GA2Purine nucleoside phosphorylase DeoD-type2.4.2.10.457
4da7AC2Purine nucleoside phosphorylase DeoD-type2.4.2.10.457
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.457
4g2gTDHMycocyclosin synthase1.14.21.90.457
4hyf1AKTankyrase-22.4.2.300.457
4li81XQTankyrase-12.4.2.300.457
5kf9ACOPredicted acetyltransferase/0.457
4uhrNGIAdenosine receptor A2a/0.457
1cq7PY5Aspartate aminotransferase2.6.1.10.456
1hfqMOTDihydrofolate reductase1.5.1.30.456
1mj3HXCEnoyl-CoA hydratase, mitochondrial4.2.1.170.456
1n3sGTPGTP cyclohydrolase 13.5.4.160.456
1n8wCOAMalate synthase G/0.456
1qipGNBLactoylglutathione lyase4.4.1.50.456
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.456
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.456
2ittAEEEpidermal growth factor receptor2.7.10.10.456
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.456
2p1v5TNRetinoic acid receptor RXR-alpha/0.456
2q61SF1Peroxisome proliferator-activated receptor gamma/0.456
3ba6AN2Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.456
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
3i5xANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.456
4dymIYZActivin receptor type-12.7.11.300.456
4eevL1XHepatocyte growth factor receptor2.7.10.10.456
4fwfFADLysine-specific histone demethylase 1B10.456
4hshQEIQueuine tRNA-ribosyltransferase2.4.2.290.456
4jbtASDCytochrome P450 monooxygenase/0.456
4jjiNADAlcohol dehydrogenase class-3/0.456
4qjqOTRLactoperoxidase/0.456
4xbfFADLysine-specific histone demethylase 1A10.456
4mqt2CUMuscarinic acetylcholine receptor M2/0.456
1fm69CRRetinoic acid receptor RXR-alpha/0.455
1ivrCBAAspartate aminotransferase, mitochondrial2.6.1.10.455
1mu6CDAProthrombin3.4.21.50.455
1p93DEXGlucocorticoid receptor/0.455
1pt8ACOFormyl-CoA:oxalate CoA-transferase/0.455
1ygjRMCPyridoxal kinase2.7.1.350.455
2re8GSUGlutamine--tRNA ligase6.1.1.180.455
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
3d4pNADL-lactate dehydrogenase 11.1.1.270.455
3f82353Hepatocyte growth factor receptor2.7.10.10.455
3gwfFADCyclohexanone monooxygenase/0.455
3hz6ADPXylulokinase/0.455
3iktNADRedox-sensing transcriptional repressor Rex/0.455
3q8hAO92-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase/0.455
3uayADNPurine nucleoside phosphorylase DeoD-type/0.455
3w2fNADNADH-cytochrome b5 reductase 31.6.2.20.455
4ej1FOLDihydrofolate reductase1.5.1.30.455
4fam0SZAldo-keto reductase family 1 member C3/0.455
4iwc1GVEstrogen receptor/0.455
4lzwTHMUridine phosphorylase/0.455
4oztP1AEcdysone receptor, putative/0.455
4paoGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.455
4pl0ANPMicrocin-J25 export ATP-binding/permease protein McjD/0.455
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.455
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.455
1jtuLYBThymidylate synthase/0.454
1mczRMNBenzoylformate decarboxylase4.1.1.70.454
1ozqPRFQueuine tRNA-ribosyltransferase2.4.2.290.454
1pke2FDPurine nucleoside phosphorylase DeoD-type/0.454
2b04CHOPhospholipase A2, major isoenzyme3.1.1.40.454
2dshSAHDiphthine synthase/0.454
2e99B08Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.454
2r0pK2CPutative FAD-monooxygenase/0.454
3b7dCNIGlutamate receptor 2/0.454
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.454
3br3ETHTH-type transcriptional regulator QacR/0.454
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.454
3hazFADBifunctional protein PutA/0.454
3kxoKXOHematopoietic prostaglandin D synthase/0.454
4b1e6T6Beta-secretase 13.4.23.460.454
4b5oACOAlpha-tubulin N-acetyltransferase 1/0.454
4bfsZVSPantothenate kinase2.7.1.330.454
4elb34SDihydrofolate reductase/0.454
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
4hfp15UProthrombin3.4.21.50.454
4hqvQEIQueuine tRNA-ribosyltransferase2.4.2.290.454
4relKMPGlycosyltransferase/0.454
4xe606UDihydrofolate reductase1.5.1.30.454
4y6gF6FTryptophan synthase alpha chain/0.454
5ej7TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.454
1c7oPPGHemolysin/0.453
1dgbNDPCatalase1.11.1.60.453
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.453
1ry0PG2Aldo-keto reductase family 1 member C3/0.453
2e7rSAHDiphthine synthase/0.453
2olcADPMethylthioribose kinase2.7.1.1000.453
2pg0FADAcyl-CoA dehydrogenase/0.453
2x7hPFNProstaglandin reductase 310.453
3gncQQQGlutaryl-CoA dehydrogenase/0.453
3hv3R49Mitogen-activated protein kinase 14/0.453
3p6pA6BCamphor 5-monooxygenase1.14.15.10.453
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
3up0D7SaceDAF-12/0.453
3uyk0CXProbable NDP-rhamnosyltransferase/0.453
3vx4ATPPutative ABC transporter, ATP-binding protein ComA/0.453
4bamMM9Prothrombin3.4.21.50.453
4bmpFMNProtein NrdI/0.453
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.453
4ih61EPGenome polyprotein2.7.7.480.453
4rquNADAlcohol dehydrogenase class-P/0.453
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.453
5d7pAR6NAD-dependent protein deacetylase sirtuin-23.5.10.453
5epvACPBlue-light-activated histidine kinase2.7.13.30.453
1bygSTUTyrosine-protein kinase CSK/0.452
1culFOKAdenylate cyclase type 2/0.452
1culFOKAdenylate cyclase type 5/0.452
1dgfNDPCatalase1.11.1.60.452
1dr3HBIDihydrofolate reductase1.5.1.30.452
1fw0KAIGlutamate receptor 2/0.452
1n71COAAac(6')-Ii protein/0.452
1nhkCMPNucleoside diphosphate kinase2.7.4.60.452
1nzyBCA4-chlorobenzoyl coenzyme A dehalogenase3.8.1.70.452
1opbRETRetinol-binding protein 2/0.452
1towCRZFatty acid-binding protein, adipocyte/0.452
1w7h3IPMitogen-activated protein kinase 14/0.452
1wklATPNucleoside diphosphate kinase/0.452
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
1ybgTAVUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.452
2aclL05Oxysterols receptor LXR-alpha/0.452
2e0nSAHPrecorrin-2 C20-methyltransferase/0.452
2e8hSAHDiphthine synthase/0.452
2ehlSAHDiphthine synthase/0.452
2puiADPMethylthioribose kinase2.7.1.1000.452
2r2nKYNKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.452
2x9vTMQPteridine reductase/0.452
2zscBTNTamavidin2/0.452
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.452
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.452
3hqdANPKinesin-like protein KIF11/0.452
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.452
3t7vSAM3-methylornithine synthase/0.452
3uaxNOSPurine nucleoside phosphorylase DeoD-type/0.452
4gurFADLysine-specific histone demethylase 1B10.452
4i8vBHFCytochrome P450 1A11.14.14.10.452
4iaq2GM5-hydroxytryptamine receptor 1B/0.452
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.452
4yekTHMThymidine phosphorylase/0.452
4z87GDPInosine-5'-monophosphate dehydrogenase/0.452
5c1mCLRMu-type opioid receptor/0.452
5iu86DZAdenosine receptor A2a/0.452
1fmlRTLRetinol dehydratase/0.451
1kquBR4Phospholipase A2, membrane associated/0.451
1ndzFR5Adenosine deaminase3.5.4.40.451
1pd9CO4Dihydrofolate reductase1.5.1.30.451
1v3q2DIPurine nucleoside phosphorylase2.4.2.10.451
1ypgUIRProthrombin3.4.21.50.451
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.451
2aclREARetinoic acid receptor RXR-alpha/0.451
2emuSAHDiphthine synthase/0.451
2i62SAHNicotinamide N-methyltransferase2.1.1.10.451
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.451
2v3hI25Prothrombin3.4.21.50.451
2z3uCRRCytochrome P450/0.451
3ho2N323-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.451
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.451
3l9nL9NcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
3wsbRWZFarnesyltransferase, putative/0.451
3wv9FEGHmd co-occurring protein HcgE/0.451
3ziaADPATP synthase subunit beta, mitochondrial3.6.3.140.451
4n3r2GUTankyrase-12.4.2.300.451
4qii2NE1,4-dihydroxy-2-naphthoyl-CoA synthase/0.451
5cmx0G6Prothrombin3.4.21.50.451
5stdUNNScytalone dehydratase4.2.1.940.451
1n2vBDIQueuine tRNA-ribosyltransferase2.4.2.290.450
1q3aNGHStromelysin-23.4.24.220.450
1rsgFADPolyamine oxidase FMS1/0.450
1s3uTQDDihydrofolate reductase1.5.1.30.450
1srfMTBStreptavidin/0.450
1u1f183Uridine phosphorylase2.4.2.30.450
1zsnTN2Enoyl-ACP reductase/0.450
2bfpH4BPteridine reductase 11.5.1.330.450
2dvlFADAcyl-CoA dehydrogenase/0.450
2eglSAHDiphthine synthase/0.450
2ewaSB2Mitogen-activated protein kinase 14/0.450
2pirDHTAndrogen receptor/0.450
2pswCOAN-alpha-acetyltransferase 50/0.450
2x6o2TCTetracycline repressor protein class D/0.450
3cquCQURAC-alpha serine/threonine-protein kinase2.7.11.10.450
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.450
3e92G6AMitogen-activated protein kinase 14/0.450
3h3sH15Collagen type IV alpha-3-binding protein/0.450
3p2oNADBifunctional protein FolD/0.450
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.450
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.450
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.450
4c6zTLE3-oxoacyl-ACP synthase/0.450
4i1nFOLDihydrofolate reductase1.5.1.30.450
4jqh1MFAlr2278 protein/0.450
4k6i9RARetinoic acid receptor RXR-alpha/0.450
4y0kNAPAntE/0.450
5f54TMPSingle-stranded-DNA-specific exonuclease/0.450
1b2lNDCAlcohol dehydrogenase1.1.1.10.449
1dr4HBIDihydrofolate reductase1.5.1.30.449
1dtpAPUDiphtheria toxin/0.449
1kuyCOTSerotonin N-acetyltransferase/0.449
1o6qR17Squalene--hopene cyclase4.2.1.1290.449
1synF89Thymidylate synthase/0.449
1u0hONMAdenylate cyclase type 2/0.449
1u0hONMAdenylate cyclase type 5/0.449
1w19T5P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.449
1xuoLA1Integrin alpha-L/0.449
1y6qTDI5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase3.2.2.90.449
1yplRA8Prothrombin3.4.21.50.449
1zq5E04Aldo-keto reductase family 1 member C3/0.449
2fjaFADAdenylylsulfate reductase, subunit A (AprA)/0.449
2getCOKPantothenate kinase2.7.1.330.449
2itnANPEpidermal growth factor receptor2.7.10.10.449
2jh6894Prothrombin3.4.21.50.449
2jj2ANPATP synthase subunit beta, mitochondrial3.6.3.140.449
2q28ADPOxalyl-CoA decarboxylase4.1.1.80.449
2rjp886A disintegrin and metalloproteinase with thrombospondin motifs 43.4.24.820.449
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.449
2x7jTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.449
2xveFADPutative flavin-containing monooxygenase/0.449
2ym2FADPhenylacetone monooxygenase1.14.13.920.449
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.449
3h3qH13Collagen type IV alpha-3-binding protein/0.449
3n87N873-dehydroquinate dehydratase4.2.1.100.449
3pm1ETHTH-type transcriptional regulator QacR/0.449
3to3ATPPetrobactin biosynthesis protein AsbB/0.449
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.449
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
4f1mACPProbable serine/threonine-protein kinase roco42.7.11.10.449
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.449
4kwhNAPReductase homolog/0.449
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.449
4ttjFMCPurine nucleoside phosphorylase DeoD-type/0.449
5bukFADFADH2-dependent halogenase/0.449
5dstSAHProtein arginine N-methyltransferase 82.1.10.449
5iu4ZMAAdenosine receptor A2a/0.449
5iubCLRAdenosine receptor A2a/0.449
1jtqLY3Thymidylate synthase/0.448
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.448
1n9mBTNStreptavidin/0.448
1ne4RP1cAMP-dependent protein kinase type I-alpha regulatory subunit/0.448
1o8cNDPProbable acrylyl-CoA reductase AcuI1.3.1.840.448
1pr4MTPPurine nucleoside phosphorylase DeoD-type/0.448
1xdsDRAAclacinomycin 10-hydroxylase RdmB4.1.10.448
2bfmTOPPteridine reductase 11.5.1.330.448
2bifANP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 42.7.1.1050.448
2cvzNDP3-hydroxyisobutyrate dehydrogenase/0.448
2e82IM3D-amino-acid oxidase1.4.3.30.448
2ea2F77Methionine aminopeptidase 2/0.448
2h23SAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.448
2itvANPEpidermal growth factor receptor2.7.10.10.448
2qk8MTXDihydrofolate reductase/0.448
2rd2QSIGlutamine--tRNA ligase6.1.1.180.448
2wtkANPSTE20-related kinase adapter protein alpha/0.448
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.448
3eksCY9Actin-5C/0.448
3gc52MQQueuine tRNA-ribosyltransferase2.4.2.290.448
3occDIHPurine nucleoside phosphorylase DeoD-type/0.448
3oq13OQCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
4a6eASEAcetylserotonin O-methyltransferase2.1.1.40.448
4dh60KNBeta-secretase 13.4.23.460.448
4ea2RWZDehydrosqualene synthase/0.448
4edz0O5Hematopoietic prostaglandin D synthase/0.448
4rheFMNFlavin prenyltransferase UbiX/0.448
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.448
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.448
4zirANPEnergy-coupling factor transporter ATP-binding protein EcfA23.6.30.448
4zirANPEnergy-coupling factor transporter ATP-binding protein EcfA1/0.448
5ab7MLCNonspecific lipid-transfer protein, putative/0.448
5jy1NADPutative short-chain dehydrogenase/reductase/0.448
5uviZMAAdenosine receptor A2a/0.448
1a4iNDPC-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.447
1crbRTLRetinol-binding protein 1/0.447
1d4pBPPProthrombin3.4.21.50.447
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.447
1phhFADp-hydroxybenzoate hydroxylase/0.447
1ptjNAPNAD(P) transhydrogenase subunit beta1.6.1.20.447
1t4u81AProthrombin3.4.21.50.447
1touB1VFatty acid-binding protein, adipocyte/0.447
1u0wSTLChalcone synthase 22.3.1.740.447
1vbiNADMalate/L-lactate dehydrogenase family protein/0.447
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
2c31ADPOxalyl-CoA decarboxylase4.1.1.80.447
2dw4FADLysine-specific histone demethylase 1A10.447
2eixFADNADH-cytochrome b5 reductase/0.447
2fyuFDNCytochrome b/0.447
2hpsCTZCa2+-triggered coelenterazine-binding protein 1/0.447
2j4z626Aurora kinase A2.7.11.10.447
2jddACOProbable acetyltransferase/0.447
2o7pNAPRiboflavin biosynthesis protein RibD/0.447
2p5cSAHDiphthine synthase/0.447
2qd5CHDFerrochelatase, mitochondrial4.99.1.10.447
3b03VNRIsopentenyl-diphosphate delta-isomerase/0.447
3bgiSAHThiopurine S-methyltransferase2.1.1.670.447
3u9y09LTankyrase-22.4.2.300.447
4equG6ISerine/threonine-protein kinase 102.7.11.10.447
4g1nNZTPyruvate kinase PKM2.7.1.400.447
4k39SAMAnaerobic sulfatase-maturating enzyme1.8.980.447
4k4eK4ETankyrase-12.4.2.300.447
4k5p1OSM1 family aminopeptidase3.4.110.447
4l0qNADAlcohol dehydrogenase class-3/0.447
4lrrCF9Thymidylate synthase/0.447
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
4n4v2GYTankyrase-12.4.2.300.447
4rvgTYDD-mycarose 3-C-methyltransferase/0.447
5k2dZMAAdenosine receptor A2a/0.447
1mmaADPMyosin-2 heavy chain/0.446
1q6s214Tyrosine-protein phosphatase non-receptor type 13.1.3.480.446
1thnADPAnti-sigma F factor/0.446
1uydPU8Heat shock protein HSP 90-alpha/0.446
1w7kADPDihydrofolate synthase/folylpolyglutamate synthase6.3.2.120.446
1zeoC01Peroxisome proliferator-activated receptor gamma/0.446
2anmCDOProthrombin3.4.21.50.446
2bdyUNBProthrombin3.4.21.50.446
2dxxSAHDiphthine synthase/0.446
2e07SAHDiphthine synthase/0.446
2e48FADD-amino-acid oxidase1.4.3.30.446
2eniSAHDiphthine synthase/0.446
2fhjH4ZFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.446
2g8yNADHydroxycarboxylate dehydrogenase B/0.446
2hdjNDPAldo-keto reductase family 1 member C2/0.446
2pncCLUPrimary amine oxidase, liver isozyme/0.446
2vd0D27Hematopoietic prostaglandin D synthase/0.446
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.446
2zf051UProthrombin3.4.21.50.446
2zxgS23Aminopeptidase N3.4.11.20.446
3aezGDPPantothenate kinase2.7.1.330.446
3biu10UProthrombin3.4.21.50.446
3fktSIIBeta-secretase 13.4.23.460.446
3fznD7KBenzoylformate decarboxylase4.1.1.70.446
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3gcq1BUMitogen-activated protein kinase 14/0.446
3hk1B64Fatty acid-binding protein, adipocyte/0.446
3l3rOAGDihydrofolate reductase1.5.1.30.446
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3nmpPYVAbscisic acid receptor PYL2/0.446
3tdaPN0Cytochrome P450 2D6/0.446
3up3XCAaceDAF-12/0.446
4b5pACOAlpha-tubulin N-acetyltransferase 1/0.446
4bb2STRCorticosteroid-binding globulin/0.446
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.446
4ead0NPThymidine phosphorylase2.4.2.40.446
4h7zGUNQueuine tRNA-ribosyltransferase2.4.2.290.446
4ku5DCC3-oxoacyl-[ACP] synthase III/0.446
4lb2DM5Serum albumin/0.446
4psbGA3Cytokinin-specific binding protein/0.446
4zgsNADPutative D-lactate dehydrogenase/0.446
5a2yUTPMitochondrial poly(A) polymerase/0.446
5ej6TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.446
3sn6P0GBeta-2 adrenergic receptor/0.446
1dlrMXADihydrofolate reductase1.5.1.30.445
1e79ATPATP synthase subunit alpha, mitochondrial/0.445
1e79ATPATP synthase subunit beta, mitochondrial3.6.3.140.445
1je1GMPPurine nucleoside phosphorylase/0.445
1mp0NADAlcohol dehydrogenase class-31.1.1.10.445
1nbmADPATP synthase subunit beta, mitochondrial3.6.3.140.445
1rzuADPGlycogen synthase 12.4.1.210.445
1srjNABStreptavidin/0.445
1uhhCZPAequorin-2/0.445
1xddAAYIntegrin alpha-L/0.445
1xp9AIJEstrogen receptor/0.445
2fb35ADGTP 3',8-cyclase4.1.99.180.445
2fgkATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.445
2ji9ADPOxalyl-CoA decarboxylase4.1.1.80.445
2x86ADPADP-L-glycero-D-manno-heptose-6-epimerase/0.445
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.445
2ydvNECAdenosine receptor A2a/0.445
2zc922UProthrombin3.4.21.50.445
3ar7TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.445
3ey4352Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
3g0eB49Mast/stem cell growth factor receptor Kit2.7.10.10.445
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
3gx9TXDMorphinone reductase/0.445
3ig6438Urokinase-type plasminogen activator3.4.21.730.445
3pyzANPDihydrofolate synthase/folylpolyglutamate synthase/0.445
3sl2ATPSensor histidine kinase WalK/0.445
3vwdACOAlpha-tubulin N-acetyltransferase 1/0.445
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.445
4anmWULCasein kinase II subunit alpha2.7.11.10.445
4b2gV1NUncharacterized protein/0.445
4fewPP2Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.445
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.445
4l5b1UXDeoxycytidine kinase2.7.1.740.445
4nmbFADBifunctional protein PutA/0.445
4oe4NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.880.445
4r20AERCytochrome P450 family 17 polypeptide 2/0.445
4rvdSAMD-mycarose 3-C-methyltransferase/0.445
4zzjCNANAD-dependent protein deacetylase sirtuin-13.5.10.445
5coqTCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
5kf2ACOPredicted acetyltransferase/0.445
4ug2NGIAdenosine receptor A2a/0.445
3uzcT4EAdenosine receptor A2a/0.445
1fmjRTLRetinol dehydratase/0.444
1n83CLRNuclear receptor ROR-alpha/0.444
1pu9COAHAT A1/0.444
1qorNDPQuinone oxidoreductase 1/0.444
1sg0STLRibosyldihydronicotinamide dehydrogenase [quinone]/0.444
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.444
1y5xE89Queuine tRNA-ribosyltransferase2.4.2.290.444
1zg32HIIsoflavone 4'-O-methyltransferase/0.444
2fs4PZ1Renin3.4.23.150.444
2k5tCOAPanD regulatory factor/0.444
2oh4GIGVascular endothelial growth factor receptor 22.7.10.10.444
2yatEEUEstrogen receptor/0.444
3bqdDAYGlucocorticoid receptor/0.444
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.444
3ipuO40Oxysterols receptor LXR-alpha/0.444
3p6oETGCamphor 5-monooxygenase1.14.15.10.444
3qpg3QPAspartate aminotransferase2.6.1.10.444
3tubFPUTyrosine-protein kinase SYK2.7.10.20.444
3v4tUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.444
3x0a5GPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.444
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
4bftZVTPantothenate kinase2.7.1.330.444
4boeCLRJapanin/0.444
4gtt7TQGeranylgeranyl transferase type-2 subunit beta2.5.1.600.444
4q15HFGProline--tRNA ligase6.1.1.150.444
6stdMS2Scytalone dehydratase4.2.1.940.444
1bzfTMQDihydrofolate reductase1.5.1.30.443
1dd6MCIMetallo-beta-lactamase type 2/0.443
1h60STRPentaerythritol tetranitrate reductase/0.443
1o97FADElectron transfer flavoprotein subunit alpha/0.443
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
1w19T1P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.443
2aaxPDNMineralocorticoid receptor/0.443
2fjdSFDAdenylylsulfate reductase, subunit A (AprA)/0.443
2fzjDH3Dihydrofolate reductase1.5.1.30.443
2g263LGRenin3.4.23.150.443
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.443
2p6dSAHDiphthine synthase/0.443
2qe4JJ3Estrogen receptor/0.443
2w3aTOPDihydrofolate reductase1.5.1.30.443
2wnbC5PCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 12.4.99.40.443
2z1wBDIQueuine tRNA-ribosyltransferase2.4.2.290.443
2zfq45UProthrombin3.4.21.50.443
3fnfJPMEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
3fsjD7KBenzoylformate decarboxylase4.1.1.70.443
3ixp834Ecdysone receptor/0.443
3jqgAX6Pteridine reductase, putative/0.443
3n5xXFKNitric oxide synthase, brain1.14.13.390.443
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.443
3vi5M4MHematopoietic prostaglandin D synthase/0.443
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.443
4ax9N5NProthrombin3.4.21.50.443
4azwATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.443
4bgbADPPredicted molecular chaperone distantly related to HSP70-fold metalloproteases/0.443
4c717RD3-oxoacyl-ACP synthase/0.443
4edy9PQHematopoietic prostaglandin D synthase/0.443
4eixNIMPhospholipase A2 VRV-PL-VIIIa/0.443
4gg90WWQueuine tRNA-ribosyltransferase2.4.2.290.443
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
4if5ACOAlpha-tubulin N-acetyltransferase 1/0.443
4ips1G4Mycocyclosin synthase1.14.21.90.443
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.443
4k7aDHTAndrogen receptor/0.443
4qzuRTLRetinol-binding protein 2/0.443
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.443
5kf8ACOPredicted acetyltransferase/0.443
1kmvLIIDihydrofolate reductase1.5.1.30.442
1lv89PPPurine nucleoside phosphorylase2.4.2.10.442
1mjbACOHistone acetyltransferase ESA1/0.442
1puaCOAHAT A1/0.442
1txtCAAHMG-CoA synthase/0.442
1x2hLPALipoate-protein ligase A6.3.1.200.442
1xmvADPProtein RecA/0.442
1zgv501Prothrombin3.4.21.50.442
2agvTG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.442
2f98NGVAklanonic acid methyl ester cyclase AcmA5.5.1.230.442
2g0gSP0Peroxisome proliferator-activated receptor gamma/0.442
2jh5895Prothrombin3.4.21.50.442
2pb5SAHDiphthine synthase/0.442
2rd678PPoly [ADP-ribose] polymerase 12.4.2.300.442
2vcxD26Hematopoietic prostaglandin D synthase/0.442
2wn6NDPADP-ribosyltransferase enzymatic component/0.442
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.442
2zryFNRIsopentenyl-diphosphate delta-isomerase/0.442
3g72A6TRenin3.4.23.150.442
3gdpFAD(R)-mandelonitrile lyase 24.1.2.100.442
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.442
3jxeTYMTryptophan--tRNA ligase/0.442
3n65XFJNitric oxide synthase, brain1.14.13.390.442
3oafOAGDihydrofolate reductase1.5.1.30.442
3p0eBAUUridine phosphorylase 22.4.2.30.442
3p3zP3ZPutative cytochrome P450/0.442
3wleNAD(R)-specific carbonyl reductase/0.442
4ap1NAPSteroid monooxygenase/0.442
4bj9UHBTankyrase-22.4.2.300.442
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.442
4ddrMMVDihydrofolate reductase1.5.1.30.442
4fqsLYAThymidylate synthase ThyA/0.442
4gi40EXQueuine tRNA-ribosyltransferase2.4.2.290.442
4h3f10OBeta-secretase 13.4.23.460.442
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
4k4fK4FTankyrase-12.4.2.300.442
4m8hR4MRetinoic acid receptor RXR-alpha/0.442
4mt92D6Tankyrase-12.4.2.300.442
4pkl1GHUncharacterized protein/0.442
4qaiFMNNADPH dehydrogenase/0.442
4qbjNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.442
4tx9AMZPhosphoribosyl isomerase A/0.442
4zn7DESEstrogen receptor/0.442
1dggNDPCatalase1.11.1.60.441
1efvFADElectron transfer flavoprotein subunit alpha, mitochondrial/0.441
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.441
1r8qAFBCytohesin-2/0.441
1r8qAFBADP-ribosylation factor 1/0.441
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.441
2bvs2CEProthrombin3.4.21.50.441
2c9dPHR6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
2fhkMFNFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.441
2fjm073Tyrosine-protein phosphatase non-receptor type 13.1.3.480.441
2og81N8Tyrosine-protein kinase Lck2.7.10.20.441
2tplHPPTyrosine phenol-lyase4.1.99.20.441
2zhw12UProthrombin3.4.21.50.441
2ztsADPUncharacterized protein/0.441
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.441
3c1oNAPEugenol synthase/0.441
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.441
3cluFADElectron transfer flavoprotein subunit alpha/0.441
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3g70A5TRenin3.4.23.150.441
3hwxTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.441
3nx4NAPPutative oxidoreductase/0.441
3o3pGDDGlycosyl transferase, family 2/0.441
3oadLPORenin3.4.23.150.441
3qdzPRO_ALA_PRO_ARGProthrombin3.4.21.50.441
3tfyMET_LEU_GLY_PRON-alpha-acetyltransferase 502.3.10.441
3vilSA0Beta-glucosidase/0.441
4bfuZVUPantothenate kinase2.7.1.330.441
4bfyZVYPantothenate kinase2.7.1.330.441
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.441
4d7eFADPutative lysine-N-oxygenase/0.441
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.441
4h3j10WBeta-secretase 13.4.23.460.441
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.441
4j3mAJ8Tankyrase-22.4.2.300.441
4o2z046Mitogen-activated protein kinase/0.441
4ykfNAIAlkyl hydroperoxide reductase subunit F1.8.10.441
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.441
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.441
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.441
5kgjACOPredicted acetyltransferase/0.441
5kjePFBAlcohol dehydrogenase E chain1.1.1.10.441
4py06ATP2Y purinoceptor 12/0.441
4u163C0Muscarinic acetylcholine receptor M3/0.441
1d3hA26Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.440
1e92HBIPteridine reductase 11.5.1.330.440
1mvcBM6Retinoic acid receptor RXR-alpha/0.440
1p7tACOMalate synthase G/0.440
1qs2NADVip2Ac/0.440
1rd4L08Integrin alpha-L/0.440
1upw444Oxysterols receptor LXR-beta/0.440
1w0kADPATP synthase subunit alpha, mitochondrial/0.440
1w0kADPATP synthase subunit beta, mitochondrial3.6.3.140.440
1xefATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.440
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
1ygkRRCPyridoxal kinase2.7.1.350.440
1ykfNAPNADP-dependent isopropanol dehydrogenase1.1.1.800.440
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.440
2cf9348Prothrombin3.4.21.50.440
2e15SAHDiphthine synthase/0.440
2e16SAHDiphthine synthase/0.440
2gzl2AA2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.440
2huvSAHDiphthine synthase/0.440
2imfTOM2-hydroxychromene-2-carboxylate isomerase5.99.1.40.440
2p9dSAHDiphthine synthase/0.440
2pb4SAHDiphthine synthase/0.440
2pgtGPRGlutathione S-transferase P2.5.1.180.440
2y05NAPProstaglandin reductase 1/0.440
2zrxFMNIsopentenyl-diphosphate delta-isomerase/0.440
3bsyACOUDP-N-acetylbacillosamine N-acetyltransferase2.3.1.2030.440
3f7bAG5Carbonic anhydrase 44.2.1.10.440
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.440
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.440
3ou6SAMSAM-dependent methyltransferase/0.440
3qwc98PProthrombin3.4.21.50.440
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
3v94WYQPhosphodiesterase/0.440
4dju0KKBeta-secretase 13.4.23.460.440
4epq0RRPoly(ADP-ribose) glycohydrolase/0.440
4gkh0J9Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.440
4gmgNAPYersiniabactin biosynthetic protein YbtU/0.440
4gueQCTRibosomal protein S6 kinase alpha-32.7.11.10.440
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.440
4h1j0YHProtein-tyrosine kinase 2-beta2.7.10.20.440
4jtqNAPAldo-keto reductase family 1 member C2/0.440
4k9yK9YFocal adhesion kinase 12.7.10.20.440
4kc1WS1Histo-blood group ABO system transferase/0.440
4qmzB49Serine/threonine-protein kinase 242.7.11.10.440
4tl9AGSCircadian clock protein kinase KaiC2.7.11.10.440
4tqqUQ1Reaction center protein L chain/0.440
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.440
4zj8SUVOrexin receptor type 1/0.440
4xnw2IDP2Y purinoceptor 1/0.440