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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2qe5617Polyprotein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2qe5617Polyprotein/1.000
3golXNDGenome polyprotein2.7.7.480.613
3e51N35Genome polyprotein2.7.7.480.605
4ih61EPGenome polyprotein2.7.7.480.605
3hkyIX6Genome polyprotein2.7.7.480.601
4ih71ERGenome polyprotein2.7.7.480.600
3tyvHI3Genome polyprotein2.7.7.480.599
4mk728OGenome polyprotein2.7.7.480.597
3u4o08EGenome polyprotein2.7.7.480.594
3uph0C1Genome polyprotein2.7.7.480.594
1z4uPH9Polyprotein/0.593
4iz02BIGenome polyprotein2.7.7.480.585
1yvfPH7Polyprotein/0.584
3h5sH5SGenome polyprotein2.7.7.480.584
3ska053Genome polyprotein2.7.7.480.584
3co93MSGenome polyprotein2.7.7.480.583
3ske054Genome polyprotein2.7.7.480.581
2fvc888Polyprotein/0.580
3csoXNIGenome polyprotein2.7.7.480.577
3cwj321Genome polyprotein2.7.7.480.574
2yoj8Y6Genome polyprotein2.7.7.480.573
3upi0C2Genome polyprotein2.7.7.480.573
3cvkN34Genome polyprotein2.7.7.480.572
3cdeN3HGenome polyprotein2.7.7.480.569
4mk828QGenome polyprotein2.7.7.480.568
3d5m4MSGenome polyprotein2.7.7.480.559
3h98B5PGenome polyprotein2.7.7.480.558
3d28B34Genome polyprotein2.7.7.480.556
3h5uH5UGenome polyprotein2.7.7.480.556
2gc8885Polyprotein/0.554
3gynB42Genome polyprotein2.7.7.480.553
3bsa1PDGenome polyprotein2.7.7.480.548
3gnwXNCGenome polyprotein2.7.7.480.531
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.505
2gjlFMNNitronate monooxygenase1.13.12.160.502
2dvlFADAcyl-CoA dehydrogenase/0.499
4hy6FJ1Heat shock protein HSP 90-alpha/0.499
1d3pBT3Prothrombin3.4.21.50.497
2anmCDOProthrombin3.4.21.50.497
2qe2452Polyprotein/0.496
1bsvNDPGDP-L-fucose synthase/0.495
1d3dBZTProthrombin3.4.21.50.495
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.495
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.495
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.491
3b9lAZZSerum albumin/0.491
3c35KAIGlutamate receptor ionotropic, kainate 1/0.491
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.490
3fqk79ZGenome polyprotein2.7.7.480.489
1z3cSA8mRNA cap guanine-N7 methyltransferase2.1.1.560.488
4s1iPLPPyridoxal kinase, putative/0.488
5a3cNADSIR2 family protein/0.488
1ypeUIPProthrombin3.4.21.50.487
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.487
4nvk2NYPeroxidase/0.486
2zhw12UProthrombin3.4.21.50.485
3fp0FP015-O-acetyltransferase/0.485
2ft9CHDFatty acid-binding protein 2, liver/0.484
4cdmFO1Deoxyribodipyrimidine photolyase/0.483
3nn6HNK6-hydroxy-L-nicotine oxidase/0.482
4bb3KKAIsopenicillin N synthase1.21.3.10.482
4twnB96Ephrin type-A receptor 32.7.10.10.481
1zgi382Prothrombin3.4.21.50.480
3f03FMNPentaerythritol tetranitrate reductase/0.480
3mddFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.480
3zoiM2WIsopenicillin N synthase1.21.3.10.480
1oc1ASVIsopenicillin N synthase1.21.3.10.478
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.478
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.478
1t4v14AProthrombin3.4.21.50.477
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.477
3s1dZIRCytokinin dehydrogenase 11.5.99.120.477
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.477
4h3j10WBeta-secretase 13.4.23.460.477
4jxrACOAcetyltransferase/0.477
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.477
1xm1GAHProthrombin3.4.21.50.476
3maaFKPAdenylate cyclase type 2/0.476
3maaFKPAdenylate cyclase type 5/0.476
1fxsNAPGDP-L-fucose synthase/0.475
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.475
2ikuLIYRenin3.4.23.150.475
2vbpVB1Isopenicillin N synthase1.21.3.10.475
3p62FMNPentaerythritol tetranitrate reductase/0.474
3v2uATPProtein GAL3/0.474
1g1aNADdTDP-glucose 4,6-dehydratase/0.473
1obnASVIsopenicillin N synthase1.21.3.10.473
1tehNADAlcohol dehydrogenase class-31.1.1.10.473
2bdyUNBProthrombin3.4.21.50.473
2r2mI50Prothrombin3.4.21.50.473
3t4nADP5'-AMP-activated protein kinase subunit gamma/0.473
1ypjUIBProthrombin3.4.21.50.472
2fjdSFDAdenylylsulfate reductase, subunit A (AprA)/0.472
2imlFMNUncharacterized protein/0.472
2pksG44Prothrombin3.4.21.50.472
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.472
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.472
4kwhNAPReductase homolog/0.472
4xguADPPutative pachytene checkpoint protein 2/0.472
5a3bAPRSIR2 family protein/0.472
1d4pBPPProthrombin3.4.21.50.471
1e7qNAPGDP-L-fucose synthase/0.471
2a94AP0L-lactate dehydrogenase1.1.1.270.471
2cf8ESHProthrombin3.4.21.50.471
2geuCOKPantothenate kinase2.7.1.330.471
2xvv9DNSerum albumin/0.471
3c15FOKAdenylate cyclase type 2/0.471
3c15FOKAdenylate cyclase type 5/0.471
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.471
3sf6FDAGlutaryl-CoA dehydrogenase/0.471
4brdANPEctonucleoside triphosphate diphosphohydrolase I/0.471
4e2bFMNDehydrogenase/0.471
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.470
1yplRA8Prothrombin3.4.21.50.470
2g1n1IGRenin3.4.23.150.470
2y6fM9FIsopenicillin N synthase1.21.3.10.470
2zfr46UProthrombin3.4.21.50.470
4ead0NPThymidine phosphorylase2.4.2.40.470
4f3gKAIGlutamate receptor 3/0.470
1cjtFOKAdenylate cyclase type 2/0.469
1cjtFOKAdenylate cyclase type 5/0.469
1fw0KAIGlutamate receptor 2/0.469
3c1kT15Prothrombin3.4.21.50.469
3ekuCY9Actin-5C/0.469
1enoNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.468
1t4u81AProthrombin3.4.21.50.468
1xddAAYIntegrin alpha-L/0.468
2bxqIMNSerum albumin/0.468
3sl2ATPSensor histidine kinase WalK/0.468
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.468
1kvsUPGUDP-glucose 4-epimerase5.1.3.20.467
1uycPU7Heat shock protein HSP 90-alpha/0.467
2gjnFMNNitronate monooxygenase1.13.12.160.467
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.467
2uuk897Prothrombin3.4.21.50.467
2xveFADPutative flavin-containing monooxygenase/0.467
3ggs2FDPurine nucleoside phosphorylase2.4.2.10.467
3nmpPYVAbscisic acid receptor PYL2/0.467
4bahMELProthrombin3.4.21.50.467
4nh82LCHeat shock protein HSP 90-alpha/0.467
1fmlRTLRetinol dehydratase/0.466
1nm6L86Prothrombin3.4.21.50.466
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.466
2zrzFNRIsopentenyl-diphosphate delta-isomerase/0.466
3arvSAUChitinase A/0.466
3hl0NADMaleylacetate reductase/0.466
3in6FMNUncharacterized protein/0.466
4b63NAPL-ornithine N(5)-monooxygenase/0.466
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.466
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.466
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.466
5il2SAHN6-adenosine-methyltransferase 70 kDa subunit/0.466
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.465
1lf2R37Plasmepsin-23.4.23.390.465
2ejzSAHDiphthine synthase/0.465
2jb4A14Isopenicillin N synthase1.21.3.10.465
4dieC5PCytidylate kinase/0.465
4dk70KSOxysterols receptor LXR-beta/0.465
1a5bIGPTryptophan synthase alpha chain/0.464
1r2jFADFkbI/0.464
2w02ATPAcsD/0.464
2xviFADPutative flavin-containing monooxygenase/0.464
2ym1FADPhenylacetone monooxygenase1.14.13.920.464
3clsFADElectron transfer flavoprotein subunit alpha/0.464
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.464
3i8p8403-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.464
3s5wFADL-ornithine N(5)-monooxygenase/0.464
3wtkTH4Acetylcholine-binding protein/0.464
4l5aTBNS-methyl-5'-thioadenosine phosphorylase/0.464
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.464
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.464
4xnw2IDP2Y purinoceptor 1/0.464
1kc1NDPdTDP-4-dehydrorhamnose reductase1.1.1.1330.463
1m9nAMZBifunctional purine biosynthesis protein PURH2.1.2.30.463
2r8pT6FTransketolase 1/0.463
2v1aFMNNPH1-1/0.463
3fr5I4AFatty acid-binding protein, adipocyte/0.463
3p82FMNPentaerythritol tetranitrate reductase/0.463
3r7kFDAProbable acyl CoA dehydrogenase/0.463
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.463
3vmmP0DAlanine--anticapsin ligase/0.463
3zhrTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.463
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.463
1b2lNDCAlcohol dehydrogenase1.1.1.10.462
1f8gNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.462
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.462
1nzfUPGDNA beta-glucosyltransferase/0.462
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.462
1qy8RDIEndoplasmin/0.462
1vyrFMNPentaerythritol tetranitrate reductase/0.462
2ftoTMPThymidylate synthase/0.462
2vmyFFOSerine hydroxymethyltransferase/0.462
2xlrFADPutative flavin-containing monooxygenase/0.462
3qdlFMNOxygen-insensitive NADPH nitroreductase/0.462
3rlq3RQHeat shock protein HSP 90-alpha/0.462
4df2FMNNADPH dehydrogenase/0.462
1blzACVIsopenicillin N synthase1.21.3.10.461
1bwsNDPGDP-L-fucose synthase/0.461
1cf3FADGlucose oxidase1.1.3.40.461
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.461
2vcmM11Isopenicillin N synthase1.21.3.10.461
2zda32UProthrombin3.4.21.50.461
3b05FNRIsopentenyl-diphosphate delta-isomerase/0.461
3s5wNAPL-ornithine N(5)-monooxygenase/0.461
4ips1G4Mycocyclosin synthase1.14.21.90.461
4r1fADPDNA topoisomerase 2-alpha5.99.1.30.461
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.460
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.460
1dmyAZMCarbonic anhydrase 5A, mitochondrial4.2.1.10.460
1hb1OCVIsopenicillin N synthase1.21.3.10.460
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.460
2ykeYKEHeat shock protein HSP 90-alpha/0.460
3eksCY9Actin-5C/0.460
3otwCOAPhosphopantetheine adenylyltransferase/0.460
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.460
4idgNADPutative UDP-glucose 4-epimerase/0.460
4jx1CAHCamphor 5-monooxygenase1.14.15.10.460
5fm7ADPRuvB-like helicase/0.460
1c4uIH1Prothrombin3.4.21.50.459
1kvrNADUDP-glucose 4-epimerase5.1.3.20.459
1pqc444Oxysterols receptor LXR-beta/0.459
1z1fSTLResveratrol synthase/0.459
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.459
2iviACWIsopenicillin N synthase1.21.3.10.459
2vprTDCTetracycline repressor protein class H/0.459
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.459
4bfuZVUPantothenate kinase2.7.1.330.459
4kw51W6Decaprenylphosphoryl-beta-D-ribose oxidase/0.459
4rww2BALmo2692 protein/0.459
4udrFAD5-(hydroxymethyl)furfural oxidase/0.459
5ej8TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.459
1cs4FOKAdenylate cyclase type 2/0.458
1cs4FOKAdenylate cyclase type 5/0.458
1p0hCOAMycothiol acetyltransferase2.3.1.1890.458
2a1mCAMCamphor 5-monooxygenase1.14.15.10.458
2c20NADUDP-glucose 4-epimerase/0.458
2g8yNADHydroxycarboxylate dehydrogenase B/0.458
2gv8FADThiol-specific monooxygenase1.14.130.458
3d8vUD1Bifunctional protein GlmU/0.458
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.458
3vx4ATPPutative ABC transporter, ATP-binding protein ComA/0.458
4c72TLG3-oxoacyl-ACP synthase/0.458
4oztP1AEcdysone receptor, putative/0.458
4qaiFMNNADPH dehydrogenase/0.458
1h74ADPHomoserine kinase2.7.1.390.457
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.457
2w6zL21Biotin carboxylase6.3.4.140.457
2yvwEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.457
3adaNADSubunit alpha of sarocosine oxidase/0.457
3d4pNADL-lactate dehydrogenase 11.1.1.270.457
3d7kD7KBenzaldehyde lyase/0.457
3fhxPXLPyridoxal kinase2.7.1.350.457
3fhxPLPPyridoxal kinase2.7.1.350.457
4b4w9L9Bifunctional protein FolD/0.457
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.457
1egeFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.456
1icuFMNOxygen-insensitive NAD(P)H nitroreductase/0.456
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.456
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.456
1qiqACCIsopenicillin N synthase1.21.3.10.456
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.456
2gevCOKPantothenate kinase2.7.1.330.456
2jh5895Prothrombin3.4.21.50.456
2q9fC3SCholesterol 24-hydroxylase/0.456
2w71L23Biotin carboxylase6.3.4.140.456
3r5yF42Uncharacterized protein/0.456
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.456
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.456
4l5b1UXDeoxycytidine kinase2.7.1.740.456
5dp2NAPCurF/0.456
5ej6TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.456
5ejaTD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.456
1bgqRDCATP-dependent molecular chaperone HSP82/0.455
1bk0ACVIsopenicillin N synthase1.21.3.10.455
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
1pq944BOxysterols receptor LXR-beta/0.455
2rlcCHDCholoylglycine hydrolase3.5.1.240.455
2zc922UProthrombin3.4.21.50.455
3bv2P38Mitogen-activated protein kinase 14/0.455
3d3wNAPL-xylulose reductase1.1.1.100.455
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.455
3kb1ADPIron-sulfur cluster carrier protein/0.455
3kozZ97D-ornithine 4,5-aminomutase subunit beta/0.455
3lqfNADGalactitol dehydrogenase/0.455
3to3ATPPetrobactin biosynthesis protein AsbB/0.455
4ce3L4VATP-dependent molecular chaperone HSP82/0.455
4dbzNDPPutative ketoacyl reductase1.3.10.455
4kxjP34Nucleoprotein/0.455
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.455
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.455
1culFOKAdenylate cyclase type 2/0.454
1culFOKAdenylate cyclase type 5/0.454
1d6w00RProthrombin3.4.21.50.454
1pd9CO4Dihydrofolate reductase1.5.1.30.454
2rbeZMGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
2zhf49UProthrombin3.4.21.50.454
3c34KAIGlutamate receptor ionotropic, kainate 1/0.454
3fr4F8AFatty acid-binding protein, adipocyte/0.454
3ndcSAHPrecorrin-4 C(11)-methyltransferase2.1.1.1330.454
4b1e6T6Beta-secretase 13.4.23.460.454
4b65FADL-ornithine N(5)-monooxygenase/0.454
4b79NADProbable short-chain dehydrogenase/0.454
4m5pFMNNADPH dehydrogenase/0.454
4uugPXGBranched-chain amino acid aminotransferase, putative/0.454
1cjvFOKAdenylate cyclase type 2/0.453
1cjvFOKAdenylate cyclase type 5/0.453
1hfqMOTDihydrofolate reductase1.5.1.30.453
1zgv501Prothrombin3.4.21.50.453
2fj1CTCTetracycline repressor protein class D/0.453
2ofv242Tyrosine-protein kinase Lck2.7.10.20.453
2rqfJH3Hemolymph juvenile hormone binding protein/0.453
2y60M8FIsopenicillin N synthase1.21.3.10.453
3ac1KZITyrosine-protein kinase Lck2.7.10.20.453
4b2gV1NUncharacterized protein/0.453
4bqjXKLHeat shock protein HSP 90-alpha/0.453
4e2dFMNDehydrogenase/0.453
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.453
4fmxCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.453
4yaiNAIC alpha-dehydrogenase/0.453
1drhNAPDihydrofolate reductase1.5.1.30.452
1f20FADNitric oxide synthase, brain1.14.13.390.452
1i3lNADUDP-glucose 4-epimerase/0.452
1sb1165Prothrombin3.4.21.50.452
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
1uy8PU5Heat shock protein HSP 90-alpha/0.452
2abbFMNPentaerythritol tetranitrate reductase/0.452
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.452
2jlaTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.452
2q7vFADThioredoxin reductase/0.452
3bi6396Wee1-like protein kinase2.7.10.20.452
3v0p4GWHisto-blood group ABO system transferase/0.452
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.452
4pkl1GHUncharacterized protein/0.452
4tleAGSCircadian clock protein kinase KaiC2.7.11.10.452
4u8iFDAUDP-galactopyranose mutase/0.452
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.452
4ldlXQCBeta-2 adrenergic receptor/0.452
1bwlFMNNADPH dehydrogenase 11.6.99.10.451
1ci7UMPThymidylate synthase2.1.1.450.451
1fwkADPHomoserine kinase2.7.1.390.451
1hb3SCVIsopenicillin N synthase1.21.3.10.451
1ja0FMNNADPH--cytochrome P450 reductase/0.451
1knpFADL-aspartate oxidase1.4.3.160.451
1kquBR4Phospholipase A2, membrane associated/0.451
1ri1GTGmRNA cap guanine-N7 methyltransferase2.1.1.560.451
1ta6177Prothrombin3.4.21.50.451
1v35NAIEnoyl-ACP reductase/0.451
2jh0701Prothrombin3.4.21.50.451
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.451
2ykiYKIHeat shock protein HSP 90-alpha/0.451
4uyg73BBromodomain-containing protein 2/0.451
1ae8AZLProthrombin3.4.21.50.450
1dhrNADDihydropteridine reductase1.5.1.340.450
1i5zCMPcAMP-activated global transcriptional regulator CRP/0.450
1ju2FAD(R)-mandelonitrile lyase 24.1.2.100.450
1mewXMPInosine-5'-monophosphate dehydrogenase/0.450
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.450
2b4rNADGlyceraldehyde-3-phosphate dehydrogenase/0.450
2o23NAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.450
2zfq45UProthrombin3.4.21.50.450
3clrFADElectron transfer flavoprotein subunit alpha/0.450
3jv7NADSecondary alcohol dehydrogenase/0.450
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
3qj5022Alcohol dehydrogenase class-31.1.1.10.450
3tjlFMNNADPH dehydrogenase/0.450
3zkyWT4Isopenicillin N synthase1.21.3.10.450
4ocvANPAminoglycoside phosphotransferase/0.450
4rh10TTSpore photoproduct lyase/0.450
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.450
5efwFMNNPH1-1/0.450
3qakUKAAdenosine receptor A2a/0.450
1ddsMTXDihydrofolate reductase1.5.1.30.449
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1kmvLIIDihydrofolate reductase1.5.1.30.449
1kr2TADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.449
1kvkATPMevalonate kinase2.7.1.360.449
1s1rNAPAldo-keto reductase family 1 member C3/0.449
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.449
2idkC2FGlycine N-methyltransferase2.1.1.200.449
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.449
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.449
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.449
3b04OOPIsopentenyl-diphosphate delta-isomerase/0.449
3b8z294A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.449
3djjFADGlutathione reductase, mitochondrial1.8.1.70.449
3docNADGlyceraldehyde-3-phosphate dehydrogenase/0.449
3qto10PProthrombin3.4.21.50.449
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.449
4ejmNAPPutative zinc-binding dehydrogenase/0.449
4ipw1G7Mycocyclosin synthase1.14.21.90.449
4l0qNADAlcohol dehydrogenase class-3/0.449
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.449
1cjuFOKAdenylate cyclase type 2/0.448
1cjuFOKAdenylate cyclase type 5/0.448
1fy7COAHistone acetyltransferase ESA1/0.448
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.448
1kqoDNDNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.448
1mvtDTMDihydrofolate reductase1.5.1.30.448
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.448
1u2yGOXPancreatic alpha-amylase/0.448
1udaUFGUDP-glucose 4-epimerase5.1.3.20.448
1uyfPU1Heat shock protein HSP 90-alpha/0.448
1vfrFMNMajor NAD(P)H-flavin oxidoreductase1.6.990.448
1wwkNAD307aa long hypothetical phosphoglycerate dehydrogenase/0.448
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.448
2gqrADPPhosphoribosylaminoimidazole-succinocarboxamide synthase6.3.2.60.448
2kceD16Thymidylate synthase/0.448
2p5nNDPAldo-keto reductase family 1 member C211.1.10.448
2zgx29UProthrombin3.4.21.50.448
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.448
3hz5Z64Heat shock protein HSP 90-alpha/0.448
3o6o94MHeat shock protein 83/0.448
3t7qRB4Endothiapepsin3.4.23.220.448
3w8eNAD3-hydroxybutyrate dehydrogenase/0.448
3zxzKRWHepatocyte growth factor receptor2.7.10.10.448
4ly91YYGlucokinase regulatory protein/0.448
4n3l2FNProthrombin3.4.21.50.448
4s0vSUVOrexin receptor type 2/0.448
1c4yIH3Prothrombin3.4.21.50.447
1d9i00PProthrombin3.4.21.50.447
1jpaANPEphrin type-B receptor 22.7.10.10.447
1nzq162Prothrombin3.4.21.50.447
1o97FADElectron transfer flavoprotein subunit alpha/0.447
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.447
1v3q2DIPurine nucleoside phosphorylase2.4.2.10.447
2eeqSAHDiphthine synthase/0.447
2oapANPType II secretion system protein (GspE-2)/0.447
2oorNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.447
2vb8TLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.447
2x9dITCTetracycline repressor protein class D/0.447
2zhq27UProthrombin3.4.21.50.447
3a0tADPSensor histidine kinase/0.447
3af1GDPPantothenate kinase2.7.1.330.447
3b03VNRIsopentenyl-diphosphate delta-isomerase/0.447
3f3sNADLambda-crystallin homolog/0.447
3ieuGDPGTPase Era/0.447
3o0iP54Heat shock protein HSP 90-alpha/0.447
3ol5SAWCamphor 5-monooxygenase1.14.15.10.447
3qwc98PProthrombin3.4.21.50.447
4alxIZNAcetylcholine-binding protein/0.447
4eepFMNPhototropin-22.7.11.10.447
4ey6GNTAcetylcholinesterase3.1.1.70.447
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.447
4nwiCTN7-methylguanosine phosphate-specific 5'-nucleotidase/0.447
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
5kghACOPredicted acetyltransferase/0.447
1srgMHBStreptavidin/0.446
1upw444Oxysterols receptor LXR-beta/0.446
1z6tADPApoptotic protease-activating factor 1/0.446
2bjsACVIsopenicillin N synthase1.21.3.10.446
2bu9HFVIsopenicillin N synthase1.21.3.10.446
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.446
2fgkATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.446
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.446
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.446
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.446
2zrxFMNIsopentenyl-diphosphate delta-isomerase/0.446
3ai2NDPNADPH-sorbose reductase/0.446
3bw4FMNPutative 2-nitropropane dioxygenase/0.446
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.446
4br0AU1Ectonucleoside triphosphate diphosphohydrolase 2/0.446
4esoNAPPutative oxidoreductase/0.446
4friDWABeta-secretase 13.4.23.460.446
4gk2L66Ephrin type-A receptor 32.7.10.10.446
4ktkKTKCytochrome P450/0.446
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.446
5esdTDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.446
1cozCTPGlycerol-3-phosphate cytidylyltransferase2.7.7.390.445
1mrqSTRAldo-keto reductase family 1 member C1/0.445
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.445
1x1aSAMC-20 methyltransferase/0.445
2aa3AP0L-lactate dehydrogenase/0.445
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.445
2dsgSAHDiphthine synthase/0.445
2p20PRXAcetyl-coenzyme A synthetase/0.445
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.445
2r59PH0Leukotriene A-4 hydrolase3.3.2.60.445
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.445
3dhcCYKN-acyl homoserine lactonase AiiA3.1.1.810.445
3eteNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.445
3h3qH13Collagen type IV alpha-3-binding protein/0.445
3h3sH15Collagen type IV alpha-3-binding protein/0.445
3hdyGDUUDP-galactopyranose mutase/0.445
3pe2E1BCasein kinase II subunit alpha2.7.11.10.445
3tjsD0RCytochrome P450 3A4/0.445
4b4vL34Bifunctional protein FolD/0.445
4b78KGGBeta-secretase 13.4.23.460.445
4ho8THMGlucose-1-phosphate thymidylyltransferase/0.445
4i6gFADCryptochrome-2/0.445
4mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.445
4nmdFDABifunctional protein PutA/0.445
4ww4ADPRuvB-like helicase/0.445
4xr9NADCalS8/0.445
1fm4DXCMajor pollen allergen Bet v 1-L/0.444
1h63FMNPentaerythritol tetranitrate reductase/0.444
1hdgNADGlyceraldehyde-3-phosphate dehydrogenase/0.444
1j0xNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.444
1mg5NAIAlcohol dehydrogenase1.1.1.10.444
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.444
2po7CHDFerrochelatase, mitochondrial4.99.1.10.444
2v3hI25Prothrombin3.4.21.50.444
2vbdV10Isopenicillin N synthase1.21.3.10.444
2wd4TBVAscorbate peroxidase/0.444
2yjxYJXHeat shock protein HSP 90-alpha/0.444
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.444
3br3ETHTH-type transcriptional regulator QacR/0.444
3cb2GDPTubulin gamma-1 chain/0.444
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.444
3cw901A4-chlorobenzoyl CoA ligase/0.444
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.444
3mauPLRPutative sphingosine-1-phosphate lyase/0.444
3tgpGNPGTPase HRas/0.444
4e5kNADPhosphonate dehydrogenase1.20.1.10.444
4fdnFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.444
4fweFADLysine-specific histone demethylase 1B10.444
4gl4NAIAlcohol dehydrogenase class-3/0.444
4h3i10VBeta-secretase 13.4.23.460.444
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.444
4jlm1NNDeoxycytidine kinase2.7.1.740.444
4kbyC2EStimulator of interferon genes protein/0.444
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.444
1beuIPLTryptophan synthase alpha chain/0.443
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1iqrFADDeoxyribodipyrimidine photo-lyase4.1.99.30.443
1lkeDOGBilin-binding protein/0.443
1mvsDTMDihydrofolate reductase1.5.1.30.443
1rpwDIDHTH-type transcriptional regulator QacR/0.443
1uyiPUZHeat shock protein HSP 90-alpha/0.443
1ycgFMNNitric oxide reductase10.443
2a5hSAML-lysine 2,3-aminomutase5.4.3.20.443
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.443
2c4iBTNAvidin/0.443
2el0SAHDiphthine synthase/0.443
2gv8NDPThiol-specific monooxygenase1.14.130.443
2i7pACOPantothenate kinase 32.7.1.330.443
2il2LIXRenin3.4.23.150.443
2webPP4Penicillopepsin-13.4.23.200.443
2x3jATPAcsD/0.443
2zshGA3Gibberellin receptor GID1A30.443
3dhaC6LN-acyl homoserine lactonase AiiA3.1.1.810.443
3kry3KRCollagenase 33.4.240.443
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.443
3oqkS52Renin3.4.23.150.443
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.443
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.443
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.443
4bakM67Prothrombin3.4.21.50.443
4fcr0TMHeat shock protein HSP 90-alpha/0.443
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.443
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.443
4i1iNADMalate dehydrogenase/0.443
4l8u9AZSerum albumin/0.443
4tlaADPCircadian clock protein kinase KaiC2.7.11.10.443
4uymVOR14-alpha sterol demethylase Cyp51B/0.443
5c3zACPRibokinase/0.443
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
5koiNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.443
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.442
1g9cBABBotulinum neurotoxin type B3.4.24.690.442
1j9zFADNADPH--cytochrome P450 reductase/0.442
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.442
1osvCHCBile acid receptor/0.442
1ry0PG2Aldo-keto reductase family 1 member C3/0.442
1uymPU3Heat shock protein HSP 90-beta/0.442
1vbiNADMalate/L-lactate dehydrogenase family protein/0.442
1x8lOXRRetinol dehydratase/0.442
1yryMSGPurine nucleoside phosphorylase2.4.2.10.442
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.442
2ebaFADPutative glutaryl-CoA dehydrogenase/0.442
2ihuTP9N(2)-(2-carboxyethyl)arginine synthase/0.442
2v59LZKBiotin carboxylase6.3.4.140.442
2w3mFOLDihydrofolate reductase1.5.1.30.442
2x7hPFNProstaglandin reductase 310.442
2yy7NADL-threonine dehydrogenase/0.442
2zreAGSProtein RecA/0.442
3ai3NDPNADPH-sorbose reductase/0.442
3bl7DD1m7GpppX diphosphatase3.6.1.590.442
3coy53HPantothenate synthetase6.3.2.10.442
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3hatGLY_VAL_ARG_RNGProthrombin3.4.21.50.442
3hnzPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.442
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.442
3r3sNADPutative oxidoreductase/0.442
3toxNAPPutative oxidoreductase/0.442
3udn09BBeta-secretase 13.4.23.460.442
4b68NAPL-ornithine N(5)-monooxygenase/0.442
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
4pnmNU1Tankyrase-22.4.2.300.442
4qecNAPElxO/0.442
4rquNADAlcohol dehydrogenase class-P/0.442
4rvgTYDD-mycarose 3-C-methyltransferase/0.442
4y1bNAPAntE/0.442
5a8aADPRiboflavin biosynthesis protein RibF2.7.1.260.442
5ej4TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.442
5stdUNNScytalone dehydratase4.2.1.940.442
1am1ADPATP-dependent molecular chaperone HSP82/0.441
1dirNADDihydropteridine reductase1.5.1.340.441
1h50FMNPentaerythritol tetranitrate reductase/0.441
1k22MELProthrombin3.4.21.50.441
1nhhANPDNA mismatch repair protein MutL/0.441
1trgCB3Thymidylate synthase/0.441
1u2gAPRNAD(P) transhydrogenase subunit alpha part 11.6.1.20.441
1xe55FEPlasmepsin-23.4.23.390.441
1y7lASN_LEU_ASN_ILECysteine synthase2.5.1.470.441
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.441
2ehlSAHDiphthine synthase/0.441
2iko7IGRenin3.4.23.150.441
2j08FADDeoxyribodipyrimidine photo-lyase4.1.99.30.441
2jh6894Prothrombin3.4.21.50.441
2ooyATP5'-AMP-activated protein kinase subunit gamma/0.441
2q4wFADCytokinin dehydrogenase 71.5.99.120.441
2qfoA51Heat shock protein HSP 90-alpha/0.441
3h06VBPGlutamate receptor 2/0.441
3h3r14HCollagen type IV alpha-3-binding protein/0.441
3icpNADNAD-dependent epimerase/dehydratase/0.441
3ivcFG4Pantothenate synthetase6.3.2.10.441
3mdvCL6Cholesterol 24-hydroxylase/0.441
3mj4URMUDP-galactopyranose mutase/0.441
3p3zP3ZPutative cytochrome P450/0.441
3qofGDPAtlastin-13.6.50.441
3r4pFU7Heat shock protein HSP 90-alpha/0.441
3rdqDTBStreptavidin/0.441
3rlr3RRHeat shock protein HSP 90-alpha/0.441
4dpy2P0Mevalonate diphosphate decarboxylase/0.441
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.441
4hxyNDPPlm1/0.441
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.441
4idpGNPAtlastin-13.6.50.441
4k38SAMAnaerobic sulfatase-maturating enzyme1.8.980.441
4k6fNAPPutative Acetoacetyl-CoA reductase/0.441
4la1FADThioredoxin glutathione reductase/0.441
4ldkFADFAD-linked sulfhydryl oxidase ALR1.8.3.20.441
4m2bUPGUDP-glucose pyrophosphorylase/0.441
4nauAGSPhosphopantetheine adenylyltransferase/0.441
4wudANPDNA gyrase subunit B/0.441
1ao05GPAmidophosphoribosyltransferase/0.440
1cjkFOKAdenylate cyclase type 2/0.440
1cjkFOKAdenylate cyclase type 5/0.440
1geeNADGlucose 1-dehydrogenase1.1.1.470.440
1u1gBBBUridine phosphorylase2.4.2.30.440
1xmmM7Gm7GpppX diphosphatase3.6.1.590.440
1ypmRA4Prothrombin3.4.21.50.440
2admSAMModification methylase TaqI2.1.1.720.440
2an9GDPGuanylate kinase2.7.4.80.440
2g76NADD-3-phosphoglycerate dehydrogenase1.1.1.950.440
2givACOHistone acetyltransferase KAT8/0.440
2hg1N5OEndoplasmin/0.440
2p5uNADUDP-glucose 4-epimerase/0.440
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.440
2zbaZBATrichothecene 3-O-acetyltransferase/0.440
2zruFMNIsopentenyl-diphosphate delta-isomerase/0.440
3aosJH2Hemolymph juvenile hormone binding protein/0.440
3p1799PProthrombin3.4.21.50.440
3q3cNADNAD-dependent L-serine dehydrogenase/0.440
3t5iSER_SER_CMT_FARRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.440
4dju0KKBeta-secretase 13.4.23.460.440
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.440
4ho9UTPGlucose-1-phosphate thymidylyltransferase/0.440
4jicFMNGTN Reductase/0.440
4k9oTPPBenzoylformate decarboxylase4.1.1.70.440
4l4xNDPAmphI/0.440
4nwzFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.440
4o0mATPCircadian clock protein kinase KaiC2.7.11.10.440
4rvfTYDD-mycarose 3-C-methyltransferase/0.440
4tqgNDPPutative dTDP-d-glucose 4 6-dehydratase/0.440
4xfjANPArgininosuccinate synthase/0.440
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.440
7catNDPCatalase1.11.1.60.440