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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3g1oRF1HTH-type transcriptional regulator EthR

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
3g1oRF1HTH-type transcriptional regulator EthR/1.000
3o8gO8GHTH-type transcriptional regulator EthR/0.592
3tp0FO5HTH-type transcriptional regulator EthR/0.577
3g1mRF3HTH-type transcriptional regulator EthR/0.574
3q0vLL4HTH-type transcriptional regulator EthR/0.568
3q0uLL3HTH-type transcriptional regulator EthR/0.562
3sfi3SFHTH-type transcriptional regulator EthR/0.559
4dw60MNHTH-type transcriptional regulator EthR/0.554
3o8hO8HHTH-type transcriptional regulator EthR/0.532
3g1lRF2HTH-type transcriptional regulator EthR/0.531
3oafOAGDihydrofolate reductase1.5.1.30.503
4a8v2ANMajor pollen allergen Bet v 1-J/0.500
1pq944BOxysterols receptor LXR-beta/0.491
4a81DXCMajor pollen allergen Bet v 1-A/0.490
4a83DXCMajor pollen allergen Bet v 1-A/0.488
2a1oCAMCamphor 5-monooxygenase1.14.15.10.487
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.486
1z6tADPApoptotic protease-activating factor 1/0.485
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.484
3qtuX44Cyclin-dependent kinase 22.7.11.220.484
1ia1NDPDihydrofolate reductase1.5.1.30.483
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.483
2pg0FADAcyl-CoA dehydrogenase/0.483
2yeiXQIHeat shock protein HSP 90-alpha/0.483
2vcmM11Isopenicillin N synthase1.21.3.10.482
4ejgNCTCytochrome P450 2A131.14.14.10.482
1phgMYTCamphor 5-monooxygenase1.14.15.10.481
1t86CAMCamphor 5-monooxygenase1.14.15.10.481
4a87NARMajor pollen allergen Bet v 1-A/0.481
1bwlFMNNADPH dehydrogenase 11.6.99.10.480
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.480
4an4DUDPutative glycosyl transferase/0.480
4ejmNAPPutative zinc-binding dehydrogenase/0.480
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.480
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.479
1cbfSAHCobalt-precorrin-4 C(11)-methyltransferase2.1.1.2710.477
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.477
2eeqSAHDiphthine synthase/0.477
2he5NDPAldo-keto reductase family 1 member C211.1.10.477
2zbaZBATrichothecene 3-O-acetyltransferase/0.477
3t3r9PLCytochrome P450 2A61.14.130.477
1s3uTQDDihydrofolate reductase1.5.1.30.476
2xvv9DNSerum albumin/0.476
1m9rINENitric oxide synthase, endothelial1.14.13.390.475
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.475
4eph0RKCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.475
4g95OAGDihydrofolate reductase1.5.1.30.475
4i8vBHFCytochrome P450 1A11.14.14.10.475
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.474
2qo9ANPEphrin type-A receptor 32.7.10.10.474
4c77N01Phenylacetone monooxygenase1.14.13.920.474
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.474
2j9lATPH(+)/Cl(-) exchange transporter 5/0.473
2zwaSAHtRNA wybutosine-synthesizing protein 42.1.1.2900.473
3wthIM4Acetylcholine-binding protein/0.473
1eyqNARChalcone--flavonone isomerase 15.5.1.60.472
2dhfDZFDihydrofolate reductase1.5.1.30.472
2gjlFMNNitronate monooxygenase1.13.12.160.472
4a802ANMajor pollen allergen Bet v 1-A/0.472
2rhrEMOPutative ketoacyl reductase1.3.10.471
2vbpVB1Isopenicillin N synthase1.21.3.10.471
4gg1TZDBenzoylformate decarboxylase4.1.1.70.471
4j6dTESCytochrome P450 monooxygenase/0.471
4q72FADBifunctional protein PutA/0.471
1oc1ASVIsopenicillin N synthase1.21.3.10.470
2aclREARetinoic acid receptor RXR-alpha/0.470
2fznFADBifunctional protein PutA1.5.5.20.470
2wpwACOOrf14/0.470
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.470
4phlPILPhosphodiesterase/0.470
4q71FADBifunctional protein PutA/0.470
4ztvTA7Anthranilate phosphoribosyltransferase/0.470
4fmxCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.469
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.469
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.469
4q73FADBifunctional protein PutA/0.469
3mnrSD1Heat shock protein HSP 90-alpha/0.468
3triNAPPyrroline-5-carboxylate reductase/0.468
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.468
3wv9FEGHmd co-occurring protein HcgE/0.468
3zoiM2WIsopenicillin N synthase1.21.3.10.468
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.468
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.468
1a72PADAlcohol dehydrogenase E chain1.1.1.10.467
1x2hLPALipoate-protein ligase A6.3.1.200.467
1zdwFLVPrenyltransferase/0.467
2dshSAHDiphthine synthase/0.467
4a4wYFBPeroxisome proliferator-activated receptor gamma/0.467
2aqbTL63-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.466
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.466
2c29NAPDihydroflavonol 4-reductase/0.466
2ejzSAHDiphthine synthase/0.466
2hckQUETyrosine-protein kinase HCK2.7.10.20.466
3btsNADGalactose/lactose metabolism regulatory protein GAL80/0.466
1fm4DXCMajor pollen allergen Bet v 1-L/0.465
1mvsDTMDihydrofolate reductase1.5.1.30.465
1pg3PRXAcetyl-coenzyme A synthetase/0.465
2jb4A14Isopenicillin N synthase1.21.3.10.465
2z97CAMCamphor 5-monooxygenase1.14.15.10.465
3qlrNDPDihydrofolate reductase1.5.1.30.465
4enhFVXCholesterol 24-hydroxylase/0.465
4zm6ACON-acetyl-beta-D glucosaminidase/0.465
1hvyD16Thymidylate synthase2.1.1.450.464
1pqc444Oxysterols receptor LXR-beta/0.464
2bu9HFVIsopenicillin N synthase1.21.3.10.464
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.464
2o4rVD5Vitamin D3 receptor/0.464
2owuSAHDiphthine synthase/0.464
2z3uCRRCytochrome P450/0.464
3ai3NDPNADPH-sorbose reductase/0.464
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.464
3v2uATPProtein GAL3/0.464
4c0bATPmRNA cleavage and polyadenylation factor CLP1/0.464
4eji0QACytochrome P450 2A131.14.14.10.464
5il2SAHN6-adenosine-methyltransferase 70 kDa subunit/0.464
1njfAGSDNA polymerase III subunit tau2.7.7.70.463
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.463
2z6rSAHDiphthine synthase/0.463
3vf60H6Glucokinase2.7.1.20.463
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.463
4eu9COASuccinyl-CoA:acetate CoA-transferase/0.463
4xnhACON-terminal acetyltransferase A complex subunit NAT52.3.10.463
1obnASVIsopenicillin N synthase1.21.3.10.462
1qiqACCIsopenicillin N synthase1.21.3.10.462
1t87CAMCamphor 5-monooxygenase1.14.15.10.462
1udaUFGUDP-glucose 4-epimerase5.1.3.20.462
1uyuCAMCamphor 5-monooxygenase1.14.15.10.462
2cibCM6Lanosterol 14-alpha demethylase1.14.13.700.462
2q9fC3SCholesterol 24-hydroxylase/0.462
2xvw9NRSerum albumin/0.462
4jufTPPBenzoylformate decarboxylase4.1.1.70.462
4mprTPPBenzoylformate decarboxylase4.1.1.70.462
4pnrG18Tankyrase-22.4.2.300.462
1jpaANPEphrin type-B receptor 22.7.10.10.461
1mabADPATP synthase subunit beta, mitochondrial3.6.3.140.461
1rx1NAPDihydrofolate reductase1.5.1.30.461
1zrzBI1Protein kinase C iota type2.7.11.130.461
2ahrNAPPyrroline-5-carboxylate reductase/0.461
2b56UTPRNA editing complex protein MP57/0.461
2ed4FAD4-hydroxyphenylacetate 3-monooxygenase reductase component1.5.1.360.461
3f4bTCLEnoyl-acyl carrier protein reductase/0.461
3k2hLYABifunctional dihydrofolate reductase-thymidylate synthase/0.461
3vt3VDXVitamin D3 receptor/0.461
4b13NHWGlycylpeptide N-tetradecanoyltransferase/0.461
4b4vL34Bifunctional protein FolD/0.461
4bkqNAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.461
4eilUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.461
5ab6CAANonspecific lipid-transfer protein, putative/0.461
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.460
1mvtDTMDihydrofolate reductase1.5.1.30.460
1nzdUPGDNA beta-glucosyltransferase/0.460
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.460
2dvlFADAcyl-CoA dehydrogenase/0.460
3gphOIDCytochrome P450 2E11.14.130.460
4caxMYAGlycylpeptide N-tetradecanoyltransferase2.3.1.970.460
4ie5MD6Alpha-ketoglutarate-dependent dioxygenase FTO/0.460
4n3cUD1UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.460
4y1bNAPAntE/0.460
4y8wSTRSteroid 21-hydroxylase/0.460
7catNDPCatalase1.11.1.60.460
1blzACVIsopenicillin N synthase1.21.3.10.459
1phePIYCamphor 5-monooxygenase1.14.15.10.459
2qbmCAMCamphor 5-monooxygenase1.14.15.10.459
2zuiCAMCamphor 5-monooxygenase1.14.15.10.459
3d0bSNXHeat shock protein HSP 90-alpha/0.459
4oztP1AEcdysone receptor, putative/0.459
1a4iNDPC-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.458
1eioGCHGastrotropin/0.458
1qk35GPHypoxanthine-guanine-xanthine phosphoribosyltransferase2.4.2.220.458
2j5xGSPADP-ribosylation factor 6/0.458
2op18PCEnoyl-ACP reductase/0.458
2opsHBQGag-Pol polyprotein2.7.7.490.458
2y60M8FIsopenicillin N synthase1.21.3.10.458
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.458
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
3pqbVGPPutative oxidoreductase/0.458
3s1dZIRCytokinin dehydrogenase 11.5.99.120.458
4a862ANMajor pollen allergen Bet v 1-A/0.458
4apuA2KProgesterone receptor/0.458
4awo99BHeat shock protein HSP 90-alpha/0.458
4awq592Heat shock protein HSP 90-alpha/0.458
4dch4DCGlucokinase2.7.1.20.458
3sn6P0GBeta-2 adrenergic receptor/0.458
1gebCAMCamphor 5-monooxygenase1.14.15.10.457
1hb1OCVIsopenicillin N synthase1.21.3.10.457
1lf3EH5Plasmepsin-23.4.23.390.457
1nooCAHCamphor 5-monooxygenase1.14.15.10.457
1o76CAMCamphor 5-monooxygenase1.14.15.10.457
1vafH4BNitric oxide synthase, inducible1.14.13.390.457
3wrlCAMCamphor 5-monooxygenase1.14.15.10.457
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.457
4gs4ACOAlpha-tubulin N-acetyltransferase 1/0.457
4ie6UN9Alpha-ketoglutarate-dependent dioxygenase FTO/0.457
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.457
1dorFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.10.456
1dr3HBIDihydrofolate reductase1.5.1.30.456
1menGARTrifunctional purine biosynthetic protein adenosine-32.1.2.20.456
1piwNAPNADP-dependent alcohol dehydrogenase 61.1.1.20.456
1pt5ACOFormyl-CoA:oxalate CoA-transferase/0.456
1v59FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.456
2b4yAPRNAD-dependent protein deacylase sirtuin-5, mitochondrial/0.456
2fhlBNIAvidin-related protein 4/5/0.456
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.456
3b9lAZZSerum albumin/0.456
3g0yP9A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.456
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.456
4egnTWOCytochrome P450/0.456
4eywL0RCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.456
4nc3ERM5-hydroxytryptamine receptor 2B/0.456
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.456
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.455
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.455
1iwiCAMCamphor 5-monooxygenase1.14.15.10.455
1p0ySAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.455
1pd9CO4Dihydrofolate reductase1.5.1.30.455
1w2xRCPAcetyl-CoA carboxylase/0.455
2a1nCAMCamphor 5-monooxygenase1.14.15.10.455
2wedPP6Penicillopepsin-13.4.23.200.455
3adaNADSubunit alpha of sarocosine oxidase/0.455
3bgrT27Gag-Pol polyprotein2.7.7.490.455
3dsrADPV-type ATP synthase beta chain/0.455
3fwiCAMCamphor 5-monooxygenase1.14.15.10.455
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
4ejh0QACytochrome P450 2A131.14.14.10.455
4g2fC07Ephrin type-A receptor 32.7.10.10.455
4tkg09LTankyrase-22.4.2.300.455
4ubvCOASteroid 3-ketoacyl-CoA thiolase/0.455
5jscFADPutative acyl-CoA dehydrogenase/0.455
1njbUMPThymidylate synthase/0.454
1p8dCO1Oxysterols receptor LXR-beta/0.454
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.454
1x8lOXRRetinol dehydratase/0.454
1zeoC01Peroxisome proliferator-activated receptor gamma/0.454
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
2p6kSAHDiphthine synthase/0.454
2qboCAMCamphor 5-monooxygenase1.14.15.10.454
2rl1UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.454
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.454
3d5fL41Peroxisome proliferator-activated receptor delta/0.454
3ekuCY9Actin-5C/0.454
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
3sp9IL2Peroxisome proliferator-activated receptor delta/0.454
3wrmCAMCamphor 5-monooxygenase1.14.15.10.454
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4ha6PXMPyridoxine 4-oxidase/0.454
4haiI23Bifunctional epoxide hydrolase 23.1.3.760.454
4kp71UQ1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic1.1.1.2670.454
4lb2DM5Serum albumin/0.454
4psxCOAHistone acetyltransferase type B catalytic subunit/0.454
1ae8AZLProthrombin3.4.21.50.453
1jueFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.10.453
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.453
1t0iFMNNAD(P)H-dependent FMN reductase LOT6/0.453
1t85CAMCamphor 5-monooxygenase1.14.15.10.453
1t90NADMalonate-semialdehyde dehydrogenase1.2.1.270.453
2ay3MPPAromatic-amino-acid aminotransferase2.6.1.570.453
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.453
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.453
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.453
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.453
3a783EVVitamin D3 receptor/0.453
3fznD7KBenzoylformate decarboxylase4.1.1.70.453
3g11P9C3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.453
3pn1IVHDNA ligase/0.453
4a84DXCMajor pollen allergen Bet v 1-A/0.453
4dc1NDPPutative ketoacyl reductase1.3.10.453
4iwv1J9Glucokinase2.7.1.20.453
4j6bPLOCytochrome P450 monooxygenase/0.453
4k6fNAPPutative Acetoacetyl-CoA reductase/0.453
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.453
5bsgNAPPyrroline-5-carboxylate reductase/0.453
1a59COA2-methylcitrate synthase/0.452
1fp2HMOIsoflavone-7-O-methyltransferase 82.1.1.1500.452
1gqtACPRibokinase/0.452
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.452
1hfqMOTDihydrofolate reductase1.5.1.30.452
1m78NDPDihydrofolate reductase1.5.1.30.452
2p1v5TNRetinoic acid receptor RXR-alpha/0.452
2vbdV10Isopenicillin N synthase1.21.3.10.452
2vkeTACTetracycline repressor protein class D/0.452
3abiNADUncharacterized protein/0.452
3cppCAMCamphor 5-monooxygenase1.14.15.10.452
3lqfNADGalactitol dehydrogenase/0.452
3reoEUG(Iso)eugenol O-methyltransferase2.1.1.1460.452
3zkyWT4Isopenicillin N synthase1.21.3.10.452
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.452
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.451
1dr3TAPDihydrofolate reductase1.5.1.30.451
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.451
1ju9NADAlcohol dehydrogenase E chain1.1.1.10.451
1l3iSAHProbable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)/0.451
1m8iH4BNitric oxide synthase, inducible1.14.13.390.451
1sezOMNProtoporphyrinogen oxidase, mitochondrial1.3.3.40.451
1wl4COAAcetyl-CoA acetyltransferase, cytosolic2.3.1.90.451
1xddAAYIntegrin alpha-L/0.451
2e07SAHDiphthine synthase/0.451
2y6fM9FIsopenicillin N synthase1.21.3.10.451
2ylsFADPhenylacetone monooxygenase1.14.13.920.451
3dttNAPNADP oxidoreductase, coenzyme F420-dependent/0.451
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.451
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.451
3hx4ANPCalmodulin-domain protein kinase 1/0.451
3sx2NADUncharacterized protein/0.451
3wtkTH4Acetylcholine-binding protein/0.451
4b4w9L9Bifunctional protein FolD/0.451
4j6cSTRCytochrome P450 monooxygenase/0.451
4l4eCAMCamphor 5-monooxygenase1.14.15.10.451
4nbb9CATerminal oxygenase component of carbazole/0.451
4obuPLPPyridoxal-dependent decarboxylase domain protein/0.451
1g4tFTPThiamine-phosphate synthase/0.450
1hb3SCVIsopenicillin N synthase1.21.3.10.450
1ikvEFZGag-Pol polyprotein2.7.7.490.450
1rkgVD1Vitamin D3 receptor/0.450
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.450
2bxmIMNSerum albumin/0.450
2dsiSAHDiphthine synthase/0.450
2e83FMNFMN-binding protein/0.450
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.450
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.450
2o2sTCLEnoyl-acyl carrier reductase/0.450
2rlcCHDCholoylglycine hydrolase3.5.1.240.450
3a1l2CCCytochrome P450/0.450
3atyFMNProstaglandin F2a synthase/0.450
3aw9GDUNAD-dependent epimerase/dehydratase/0.450
3crzFADFerredoxin--NADP+ reductase/0.450
3dhcCYKN-acyl homoserine lactonase AiiA3.1.1.810.450
3lsyFT0Enoyl-ACP reductase/0.450
3lxiCAMCytochrome P450/0.450
3p2oNADBifunctional protein FolD/0.450
3tkyN7I(Iso)eugenol O-methyltransferase2.1.1.1460.450
3ty3GGGHomoisocitrate dehydrogenase1.1.1.870.450
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.450
3wrhCAMCamphor 5-monooxygenase1.14.15.10.450
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.450
4jbtASDCytochrome P450 monooxygenase/0.450
4mqy2CWUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.450
4tmcFMNOld yellow enzyme/0.450
4tuvCPZCytochrome P450 1191.140.450
4ug91EWNitric oxide synthase oxygenase1.14.13.1650.450
4ykgNADAlkyl hydroperoxide reductase subunit F1.8.10.450
1dz8CAMCamphor 5-monooxygenase1.14.15.10.449
1gthFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.20.449
1j4jACOAcetyltransferase2.3.10.449
1jutLYDThymidylate synthase/0.449
1qjfACSIsopenicillin N synthase1.21.3.10.449
1txiTX5Vitamin D3 receptor/0.449
1w6hTITPlasmepsin-23.4.23.390.449
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.449
2gfxPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.449
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.449
2o2yTCLEnoyl-ACP reductase/0.449
3aosJH2Hemolymph juvenile hormone binding protein/0.449
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.449
3inwJZBHeat shock protein HSP 90-alpha/0.449
3m30COMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.449
3m30COMMethyl-coenzyme M reductase I subunit beta2.8.4.10.449
3nmpPYVAbscisic acid receptor PYL2/0.449
3oiaA31Camphor 5-monooxygenase1.14.15.10.449
3zh8C58Protein kinase C iota type2.7.11.130.449
4bj9UHBTankyrase-22.4.2.300.449
4cf7ADPAdenylate kinase/0.449
4ef9FMNDihydroorotate dehydrogenase (fumarate)/0.449
4gyy12VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.449
4j3mAJ8Tankyrase-22.4.2.300.449
4kx6FADFumarate reductase flavoprotein subunit1.3.5.40.449
4mt92D6Tankyrase-12.4.2.300.449
4nmdFDABifunctional protein PutA/0.449
5kf8ACOPredicted acetyltransferase/0.449
1c1dNAIPhenylalanine dehydrogenase/0.448
1c7oPPGHemolysin/0.448
1hovI5272 kDa type IV collagenase3.4.24.240.448
1iwjCAMCamphor 5-monooxygenase1.14.15.10.448
1kfcIPLTryptophan synthase alpha chain/0.448
1ozvSAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.448
1uxjNADMalate dehydrogenase/0.448
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.448
2feuCAMCamphor 5-monooxygenase1.14.15.10.448
2hqpNDPDihydrofolate reductase1.5.1.30.448
3bzuA21Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3eeySAMrRNA methylase/0.448
3gobHXXDdmC/0.448
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.448
3t2sAGSHeat shock protein HSP 90-alpha/0.448
3tn8F18Cyclin-dependent kinase 92.7.11.220.448
4bquCLRJapanin/0.448
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.448
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.448
4jl6ADPAdenylate kinase/0.448
4n4t2GVTankyrase-12.4.2.300.448
4uymVOR14-alpha sterol demethylase Cyp51B/0.448
5epeSAHUncharacterized protein/0.448
4k5y1Q5Corticotropin-releasing factor receptor 1/0.448
1d3hA26Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.447
1diuBDMDihydrofolate reductase1.5.1.30.447
1gpeFADGlucose oxidase1.1.3.40.447
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1mewXMPInosine-5'-monophosphate dehydrogenase/0.447
1ozhHE3Acetolactate synthase, catabolic2.2.1.60.447
1rq1FADEndoplasmic oxidoreductin-11.8.40.447
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.447
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.447
2ed3SAHDiphthine synthase/0.447
2g6pHM2Methionine aminopeptidase 1/0.447
2hasC3OVitamin D3 receptor/0.447
2vprTDCTetracycline repressor protein class H/0.447
2yq92AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.447
3e8xNAPBH1520 protein/0.447
3eldSFGMethyltransferase/0.447
3kjm245Cytokinin dehydrogenase 11.5.99.120.447
3m7rVDXVitamin D3 receptor/0.447
3ntaCOAFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.447
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.447
3vcyUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.447
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.447
4hw219HInduced myeloid leukemia cell differentiation protein Mcl-1/0.447
4iae1DXAlr2278 protein/0.447
4ktkKTKCytochrome P450/0.447
4oviN01Phenylacetone monooxygenase1.14.13.920.447
4psbGA3Cytokinin-specific binding protein/0.447
4r7uUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.447
4xr9TMPCalS8/0.447
5adhAPRAlcohol dehydrogenase E chain1.1.1.10.447
5k7uSAMN6-adenosine-methyltransferase 70 kDa subunit/0.447
1ie8KH1Vitamin D3 receptor/0.446
2bheBRYCyclin-dependent kinase 22.7.11.220.446
2fj1CTCTetracycline repressor protein class D/0.446
2hm9TRRDihydrofolate reductase1.5.1.30.446
2huqSAHDiphthine synthase/0.446
2ozrGG1Collagenase 33.4.240.446
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
2rqfJH3Hemolymph juvenile hormone binding protein/0.446
2vwqNAPGlucose 1-dehydrogenase/0.446
2w4qCBWProstaglandin reductase 21.3.1.480.446
2wkyIBCGlutamate receptor ionotropic, kainate 1/0.446
2ykbYKBHeat shock protein HSP 90-alpha/0.446
3dd125DGlycogen phosphorylase, liver form2.4.1.10.446
3k981RCHeat shock protein HSP 90-alpha/0.446
3l63CAMCamphor 5-monooxygenase1.14.15.10.446
3qrwNDPPutative ketoacyl reductase1.3.10.446
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.446
4gk2L66Ephrin type-A receptor 32.7.10.10.446
4iteTEYVitamin D3 receptor/0.446
4jq7KJQEpidermal growth factor receptor2.7.10.10.446
4n4v2GYTankyrase-12.4.2.300.446
4q4kFMNUncharacterized protein/0.446
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.446
5fm7ADPRuvB-like helicase/0.446
5kgpACOPredicted acetyltransferase/0.446
1g2vTTPGlucose-1-phosphate thymidylyltransferase/0.445
1j3kNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
1jipKTN6-deoxyerythronolide B hydroxylase/0.445
1kzjCB3Thymidylate synthase/0.445
1me6IVSPlasmepsin-23.4.23.390.445
1suoCPZCytochrome P450 2B41.14.14.10.445
1u54ACPActivated CDC42 kinase 1/0.445
2a1mCAMCamphor 5-monooxygenase1.14.15.10.445
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
2bglNAJSecoisolariciresinol dehydrogenase1.1.1.3310.445
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.445
2ed5SAHDiphthine synthase/0.445
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
2g1r3IGRenin3.4.23.150.445
2hb8MVDVitamin D3 receptor/0.445
2nq8ZIDEnoyl-ACP reductase/0.445
2pmdGNPTranslation initiation factor 2 subunit gamma/0.445
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.445
3bejMUFBile acid receptor/0.445
3gb4D3MDdmC/0.445
3lt2FT3Enoyl-ACP reductase/0.445
3o6o94MHeat shock protein 83/0.445
3pm0BHFCytochrome P450 1B1/0.445
3s41S41Glucokinase2.7.1.20.445
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.445
3vdqNAD3-hydroxybutyrate dehydrogenase/0.445
3zuyTCHTransporter/0.445
4bqh9VUUDP-N-acetylglucosamine pyrophosphorylase, putative/0.445
4dvi2IWTankyrase-12.4.2.300.445
4ef8FMNDihydroorotate dehydrogenase (fumarate)/0.445
4f32N323-oxoacyl-[acyl-carrier-protein] synthase 2/0.445
4hy6FJ1Heat shock protein HSP 90-alpha/0.445
4ib4ERM5-hydroxytryptamine receptor 2B/0.445
4j0v1H7Beta-secretase 13.4.23.460.445
4kgkGTPUncharacterized protein/0.445
4l4bCAMCamphor 5-monooxygenase1.14.15.10.445
4r38RBFBlue-light-activated histidine kinase 22.7.13.30.445
4yqfGDPSeptin-9/0.445
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.445
5ahsFADAcyl-CoA dehydrogenase/0.445
5kgjACOPredicted acetyltransferase/0.445
3vw7VPXProteinase-activated receptor 1/0.445
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.444
1felFENRetinol-binding protein 4/0.444
1iyzNDPProbable quinone oxidoreductase/0.444
1t2cNAIL-lactate dehydrogenase1.1.1.270.444
1uymPU3Heat shock protein HSP 90-beta/0.444
1uzwCDHIsopenicillin N synthase1.21.3.10.444
1xelUPGUDP-glucose 4-epimerase5.1.3.20.444
2a94AP0L-lactate dehydrogenase1.1.1.270.444
2c12FADNitroalkane oxidase1.7.3.10.444
2djxFMNDihydroorotate dehydrogenase (fumarate)1.3.98.10.444
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.444
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.444
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.444
3c1oNAPEugenol synthase/0.444
3c3xNAPEugenol synthase 11.1.1.3180.444
3cosNADAlcohol dehydrogenase 41.1.1.10.444
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.444
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.444
3gyaCOAGCN5-related N-acetyltransferase/0.444
3i6qNDPPutative leucoanthocyanidin reductase 1/0.444
3m2uCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.444
3mztTFXBeta-2-microglobulin/0.444
3swqEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.444
3vrwYS5Vitamin D3 receptor/0.444
3wmxNADNAD dependent epimerase/dehydratase/0.444
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4blcNDPCatalase1.11.1.60.444
4c72TLG3-oxoacyl-ACP synthase/0.444
4dhyS41Glucokinase2.7.1.20.444
4fqsLYAThymidylate synthase ThyA/0.444
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.444
4if5ACOAlpha-tubulin N-acetyltransferase 1/0.444
4ixc1JDGlucokinase2.7.1.20.444
4ly91YYGlucokinase regulatory protein/0.444
4ocvANPAminoglycoside phosphotransferase/0.444
4u0mGTPCyclic GMP-AMP synthase/0.444
4w6z8IDAlcohol dehydrogenase 11.1.1.10.444
5kghACOPredicted acetyltransferase/0.444
1h36R88Squalene--hopene cyclase4.2.1.1290.443
1n83CLRNuclear receptor ROR-alpha/0.443
1u80C5PCoenzyme A biosynthesis bifunctional protein CoaBC6.3.2.50.443
1xe55FEPlasmepsin-23.4.23.390.443
2cgpCMPcAMP-activated global transcriptional regulator CRP/0.443
2cig1DGDihydrofolate reductase1.5.1.30.443
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.443
2hamC33Vitamin D3 receptor/0.443
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.443
2q3eNAIUDP-glucose 6-dehydrogenase1.1.1.220.443
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.443
3a0iAJIGlucokinase2.7.1.20.443
3ansS38Bifunctional epoxide hydrolase 23.3.2.100.443
3d76NBBPheromone-binding protein ASP1/0.443
3ig6438Urokinase-type plasminogen activator3.4.21.730.443
3lkiATPFructokinase/0.443
3lthUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.443
3upf0BUPolyprotein/0.443
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
4awp99AHeat shock protein HSP 90-alpha/0.443
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4c73TLH3-oxoacyl-ACP synthase/0.443
4krs1SXTankyrase-12.4.2.300.443
4mcc21XtRNA (guanine-N(1)-)-methyltransferase2.1.1.2280.443
4pleCPSNuclear receptor subfamily 5 group A member 2/0.443
4uqsINENitric oxide synthase oxygenase1.14.13.1650.443
1a9zUPGUDP-glucose 4-epimerase5.1.3.20.442
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1kvkATPMevalonate kinase2.7.1.360.442
1rt9IMHPurine nucleoside phosphorylase2.4.2.10.442
1x1cSAHC-20 methyltransferase/0.442
2b4rNADGlyceraldehyde-3-phosphate dehydrogenase/0.442
2b7aIZATyrosine-protein kinase JAK2/0.442
2cjpVPREpoxide hydrolase/0.442
2dxwSAHDiphthine synthase/0.442
2f2uM77Rho-associated protein kinase 22.7.11.10.442
2po7CHDFerrochelatase, mitochondrial4.99.1.10.442
2x7hPFNProstaglandin reductase 310.442
2xlrNAPPutative flavin-containing monooxygenase/0.442
2ylxFADPhenylacetone monooxygenase1.14.13.920.442
2znq401Peroxisome proliferator-activated receptor delta/0.442
3c4hDRLPoly [ADP-ribose] polymerase 32.4.2.300.442
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3exfTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.442
3exfTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.442
3fwfCAMCamphor 5-monooxygenase1.14.15.10.442
3fwjCAMCamphor 5-monooxygenase1.14.15.10.442
3ho2N323-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.442
3i2834NBifunctional epoxide hydrolase 23.3.2.100.442
4b5oACOAlpha-tubulin N-acetyltransferase 1/0.442
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.442
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.442
4l49CAMCamphor 5-monooxygenase1.14.15.10.442
4mryCEIObelin/0.442
4q0kGA3Phytohormone-binding protein/0.442
4ugaQ05Nitric oxide synthase oxygenase1.14.13.1650.442
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.442
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.442
5e8xSTUTGF-beta receptor type-12.7.11.300.442
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.442
5kf9ACOPredicted acetyltransferase/0.442
1ppjANYCytochrome b/0.441
1rfuADPPyridoxal kinase2.7.1.350.441
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.441
1sxjADPReplication factor C subunit 5/0.441
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.441
1w1rZEACytokinin dehydrogenase 11.5.99.120.441
2dv7SAHDiphthine synthase/0.441
2eglSAHDiphthine synthase/0.441
2ek2SAHDiphthine synthase/0.441
2gcgNDPGlyoxylate reductase/hydroxypyruvate reductase1.1.1.790.441
2h2jSFGRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.441
2qblCAMCamphor 5-monooxygenase1.14.15.10.441
2wgeTLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.441
2xvhFADPutative flavin-containing monooxygenase/0.441
2y30SM8Putative repressor SimReg2/0.441
2ym1FADPhenylacetone monooxygenase1.14.13.920.441
3antS82Bifunctional epoxide hydrolase 23.3.2.100.441
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3nhlYTRRibosyldihydronicotinamide dehydrogenase [quinone]/0.441
3nwzCOABH2602 protein/0.441
3nxxNDPDihydrofolate reductase1.5.1.30.441
3tjsD0RCytochrome P450 3A4/0.441
3vev0H4Glucokinase2.7.1.20.441
3vt8YI3Vitamin D3 receptor/0.441
3wrjCAMCamphor 5-monooxygenase1.14.15.10.441
3zu2NAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.441
4a33MYAGlycylpeptide N-tetradecanoyltransferase/0.441
4a9mP9MBromodomain-containing protein 2/0.441
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.441
4d04NAPPhenylacetone monooxygenase1.14.13.920.441
4dpf0LGBeta-secretase 13.4.23.460.441
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4egh0OYHeat shock protein HSP 90-alpha/0.441
4erwSTUCyclin-dependent kinase 22.7.11.220.441
4esoNAPPutative oxidoreductase/0.441
4ew3DXZTrifunctional purine biosynthetic protein adenosine-32.1.2.20.441
4fogC2FThymidylate synthase ThyA/0.441
4gk3L87Ephrin type-A receptor 32.7.10.10.441
4jlj1NMDeoxycytidine kinase2.7.1.740.441
4oqyNDP(S)-imine reductase/0.441
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.441
4xoiGTPTransforming protein RhoA/0.441
4zcaADPKinesin-like protein KIF11/0.441
5ai5BSUBifunctional epoxide hydrolase 23.1.3.760.441
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1g28FMNPHY3/0.440
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1lsoNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.440
1mv8GDXGDP-mannose 6-dehydrogenase1.1.1.1320.440
1t4v14AProthrombin3.4.21.50.440
1trgCB3Thymidylate synthase/0.440
1zx1CB1Ribosyldihydronicotinamide dehydrogenase [quinone]/0.440
2bxe1FLSerum albumin/0.440
2h2eSA8Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.440
2qenADPWalker-Type ATPase/0.440
2uuvFADAlkyldihydroxyacetonephosphate synthase2.5.1.260.440
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.440
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.440
3d75NBBPheromone-binding protein ASP1/0.440
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.440
3p3zP3ZPutative cytochrome P450/0.440
3qizQI2Botulinum neurotoxin type A3.4.24.690.440
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3s3vTOPDihydrofolate reductase1.5.1.30.440
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.440
3uyk0CXProbable NDP-rhamnosyltransferase/0.440
3vt9YI4Vitamin D3 receptor/0.440
4bqrIBHEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4c2zMYAGlycylpeptide N-tetradecanoyltransferase 1/0.440
4g3rCAMCamphor 5-monooxygenase1.14.15.10.440
4gtv7TRGeranylgeranyl transferase type-2 subunit beta2.5.1.600.440
4js9H4BNitric oxide synthase, inducible1.14.13.390.440
4l4cCAMCamphor 5-monooxygenase1.14.15.10.440
4l4fCAMCamphor 5-monooxygenase1.14.15.10.440
4y35F90Endothiapepsin3.4.23.220.440
5c7hNDPPutative oxidoreductase/0.440
5dbgNADIridoid synthase1.3.1.990.440