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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2d32ANPGlutamate--cysteine ligase6.3.2.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2d32ANPGlutamate--cysteine ligase6.3.2.21.000
1rzuADPGlycogen synthase 12.4.1.210.502
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.501
2fjbSFDAdenylylsulfate reductase, subunit A (AprA)/0.501
1dliUDXUDP-glucose 6-dehydrogenase/0.497
1nhkCMPNucleoside diphosphate kinase2.7.4.60.497
2d3aADPGlutamine synthetase root isozyme 36.3.1.20.496
3d7zGK5Mitogen-activated protein kinase 14/0.495
3h3qH13Collagen type IV alpha-3-binding protein/0.495
2po7CHDFerrochelatase, mitochondrial4.99.1.10.493
3q2jCKIAminoglycoside 3'-phosphotransferase2.7.1.950.493
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.490
2qc8ADPGlutamine synthetase6.3.1.20.490
4jauADPSensor histidine kinase/0.489
2gfsPQBMitogen-activated protein kinase 14/0.487
1w7h3IPMitogen-activated protein kinase 14/0.485
4twnB96Ephrin type-A receptor 32.7.10.10.485
2fa3ACOHydroxymethylglutaryl-CoA synthase/0.484
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.483
3qlrNDPDihydrofolate reductase1.5.1.30.483
4a0rDTBBifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial6.3.3.30.483
2a9y26AAdenosine kinase2.7.1.200.482
3l7dDK5Glycogen phosphorylase, muscle form2.4.1.10.481
4aa5NQBMitogen-activated protein kinase 14/0.481
2pl0STITyrosine-protein kinase Lck2.7.10.20.480
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.480
4aacAAVMitogen-activated protein kinase 14/0.480
2q5qKPVIndole-3-pyruvate decarboxylase4.1.1.740.479
3fr8NDPKetol-acid reductoisomerase, chloroplastic1.1.1.860.479
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.478
3pqbVGPPutative oxidoreductase/0.478
1vbiNADMalate/L-lactate dehydrogenase family protein/0.477
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.477
3p62FMNPentaerythritol tetranitrate reductase/0.477
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.476
3uk6ADPRuvB-like 23.6.4.120.476
1rw8580TGF-beta receptor type-12.7.11.300.475
2ab8MTPAdenosine kinase2.7.1.200.475
2bl4NADLactaldehyde reductase1.1.1.770.475
2bt4CA23-dehydroquinate dehydratase4.2.1.100.475
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.475
3ds6A17Mitogen-activated protein kinase 14/0.475
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.474
4jlm1NNDeoxycytidine kinase2.7.1.740.474
1knpFADL-aspartate oxidase1.4.3.160.473
1z6tADPApoptotic protease-activating factor 1/0.473
2a0yDIHPurine nucleoside phosphorylase2.4.2.10.473
3opxU5PSuppressor of disruption of TFIIS/0.473
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.473
2qenADPWalker-Type ATPase/0.472
3bi6396Wee1-like protein kinase2.7.10.20.472
3e8nVRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.472
3gbuATPUncharacterized sugar kinase PH14592.7.10.472
3x2fNAIAdenosylhomocysteinase/0.472
4jln18VDeoxycytidine kinase2.7.1.740.472
2vmyFFOSerine hydroxymethyltransferase/0.471
2vwqNAPGlucose 1-dehydrogenase/0.471
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.471
3flwFLWMitogen-activated protein kinase 14/0.471
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.471
3t8vBTJM1 family aminopeptidase3.4.110.471
4aa4QC0Mitogen-activated protein kinase 14/0.471
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.471
1b9iPXG3-amino-5-hydroxybenzoate synthase4.2.1.1440.470
1hfqMOTDihydrofolate reductase1.5.1.30.470
1t09NAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.470
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.470
1zgi382Prothrombin3.4.21.50.470
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
2pg0FADAcyl-CoA dehydrogenase/0.470
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.470
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.470
3h3r14HCollagen type IV alpha-3-binding protein/0.470
3qt62P0Mevalonate diphosphate decarboxylase/0.470
4ekeD1IGlycogen phosphorylase, muscle form2.4.1.10.470
1dr4HBIDihydrofolate reductase1.5.1.30.469
1h63FMNPentaerythritol tetranitrate reductase/0.469
1r2jFADFkbI/0.469
2b03TUDPhospholipase A2, major isoenzyme3.1.1.40.469
2b0qADPAminoglycoside 3'-phosphotransferase2.7.1.950.469
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.469
3pe2E1BCasein kinase II subunit alpha2.7.11.10.469
1h65GDPTranslocase of chloroplast 343.6.50.468
3dgeADPSensor histidine kinase/0.468
3fznD7KBenzoylformate decarboxylase4.1.1.70.468
4u0zAPCAdenosine monophosphate-protein transferase FICD2.7.7.n10.468
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.468
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.467
2uxhQUEHTH-type transcriptional regulator TtgR/0.467
2v59LZKBiotin carboxylase6.3.4.140.467
3ieuGDPGTPase Era/0.467
3k4cFADPyranose 2-oxidase/0.467
3pefNAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase/0.467
1bcpATPPertussis toxin subunit 4/0.466
1bcpATPPertussis toxin subunit 5/0.466
1h51FMNPentaerythritol tetranitrate reductase/0.466
1obnASVIsopenicillin N synthase1.21.3.10.466
2bakAQZMitogen-activated protein kinase 14/0.466
2hk9NAPShikimate dehydrogenase (NADP(+))/0.466
3angDCCTranscriptional repressor, TetR family/0.466
3c35KAIGlutamate receptor ionotropic, kainate 1/0.466
3r96ACOMccE protein/0.466
4a9yAQZMitogen-activated protein kinase 14/0.466
4fhf0TTSpore photoproduct lyase/0.466
2g8yNADHydroxycarboxylate dehydrogenase B/0.465
2zi53L1Deoxycytidine kinase2.7.1.740.465
3e92G6AMitogen-activated protein kinase 14/0.465
3raiX85Cyclin-dependent kinase 22.7.11.220.465
4olfHFGProline--tRNA ligase6.1.1.150.465
1rt9IMHPurine nucleoside phosphorylase2.4.2.10.464
2igoFADPyranose 2-oxidase/0.464
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.464
2rc6NAPFerredoxin--NADP reductase/0.464
3lfeZ84Mitogen-activated protein kinase 14/0.464
3tm0ANPAminoglycoside 3'-phosphotransferase2.7.1.950.464
4hdhATPGenome polyprotein2.7.7.480.464
4jf1PLPAcetylornithine/succinyldiaminopimelate aminotransferase2.6.1.110.464
4s1iPLPPyridoxal kinase, putative/0.464
1in5ADPHolliday junction ATP-dependent DNA helicase RuvB/0.463
1xddAAYIntegrin alpha-L/0.463
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.463
2fjdSFDAdenylylsulfate reductase, subunit A (AprA)/0.463
2jb4A14Isopenicillin N synthase1.21.3.10.463
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.463
3fowIMHPurine nucleoside phosphorylase/0.463
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.463
3iphG11Mitogen-activated protein kinase 14/0.463
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.463
4b45GSPTubulin-like protein CetZ2/0.463
4g6gFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.463
4lcg1WMUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.463
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
1u1iNADMyo-inositol-1-phosphate synthase (Ino1)/0.462
2gd6ACOProbable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )/0.462
3c1kT15Prothrombin3.4.21.50.462
3cgcCOACoenzyme A disulfide reductase/0.462
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.462
3lqfNADGalactitol dehydrogenase/0.462
4dptAGSMevalonate diphosphate decarboxylase/0.462
1npvL27Gag-Pol polyprotein3.4.23.160.461
1rszDIHPurine nucleoside phosphorylase2.4.2.10.461
1suiFRECaffeoyl-CoA O-methyltransferase2.1.1.1040.461
1z5uCMPClass B acid phosphatase/0.461
2ph5NADHomospermidine synthase/0.461
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
3hv3R49Mitogen-activated protein kinase 14/0.461
4ca83ESAngiotensin-converting enzyme3.4.15.10.461
4dpy2P0Mevalonate diphosphate decarboxylase/0.461
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.461
1hwlADP3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.460
1oc1ASVIsopenicillin N synthase1.21.3.10.460
2g37FADProline dehydrogenase/0.460
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
2rtqIMIStreptavidin/0.460
2vbpVB1Isopenicillin N synthase1.21.3.10.460
2y60M8FIsopenicillin N synthase1.21.3.10.460
3fl4FL4Mitogen-activated protein kinase 14/0.460
3h3t16HCollagen type IV alpha-3-binding protein/0.460
4zlaBESCytosol aminopeptidase3.4.11.10.460
1gc5ADPADP-dependent glucokinase2.7.1.1470.459
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.459
1yb5NAPQuinone oxidoreductase1.6.5.50.459
2x7hPFNProstaglandin reductase 310.459
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.459
3fmkFMKMitogen-activated protein kinase 14/0.459
4bgbADPPredicted molecular chaperone distantly related to HSP70-fold metalloproteases/0.459
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.459
4i9n1E5L-lactate dehydrogenase A chain1.1.1.270.459
4l9q9TPSerum albumin/0.459
4okx198Androgen receptor/0.459
4pnmNU1Tankyrase-22.4.2.300.459
4rh10TTSpore photoproduct lyase/0.459
4u07ATPAdenosine monophosphate-protein transferase FICD2.7.7.n10.459
2cftPLPPyridoxal phosphate phosphatase/0.458
2npaMMBPeroxisome proliferator-activated receptor alpha/0.458
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.458
2yj4ATPCopper-transporting ATPase/0.458
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
3c36KAIGlutamate receptor ionotropic, kainate 1/0.458
4cdmFO1Deoxyribodipyrimidine photolyase/0.458
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.458
4l5b1UXDeoxycytidine kinase2.7.1.740.458
4xnhACON-terminal acetyltransferase A complex subunit NAT52.3.10.458
5jlaNADPutative short-chain dehydrogenase/reductase/0.458
1bxoPP7Penicillopepsin-13.4.23.200.457
2a0xDIHPurine nucleoside phosphorylase2.4.2.10.457
2cjfRP43-dehydroquinate dehydratase4.2.1.100.457
2gtnLIEMitogen-activated protein kinase 14/0.457
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.457
2r0cFADPutative FAD-monooxygenase/0.457
2vbdV10Isopenicillin N synthase1.21.3.10.457
3cb2GDPTubulin gamma-1 chain/0.457
3g5qFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.457
3mvm39PMitogen-activated protein kinase 14/0.457
3s1dZIRCytokinin dehydrogenase 11.5.99.120.457
4aicNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.457
4dymIYZActivin receptor type-12.7.11.300.457
4i9bNADPutative betaine aldehyde dehyrogenase/0.457
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.457
4tvbNADHomospermidine synthase2.5.1.440.457
1dljUGAUDP-glucose 6-dehydrogenase/0.456
1g28FMNPHY3/0.456
1kc1NDPdTDP-4-dehydrorhamnose reductase1.1.1.1330.456
1m2oGNPSmall COPII coat GTPase SAR13.6.50.456
1qoqIGPTryptophan synthase alpha chain/0.456
1rfuADPPyridoxal kinase2.7.1.350.456
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.456
1txzAPRProbable ADP-ribose 1''-phosphate phosphatase YML087W3.1.3.840.456
2bfrADP[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.456
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.456
2qd9LGFMitogen-activated protein kinase 14/0.456
3itzP66Mitogen-activated protein kinase 14/0.456
5cdtNAJAlcohol dehydrogenase E chain1.1.1.10.456
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.456
1sxjADPReplication factor C subunit 5/0.455
2ji9ADPOxalyl-CoA decarboxylase4.1.1.80.455
2jk6FADTrypanothione reductase/0.455
2vwhNAPGlucose 1-dehydrogenase/0.455
2w6oOA3Biotin carboxylase6.3.4.140.455
2y6fM9FIsopenicillin N synthase1.21.3.10.455
3bx5304Mitogen-activated protein kinase 14/0.455
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.455
3fwrADPTranscriptional repressor CcpN/0.455
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.455
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
4hr2ADPNucleoside diphosphate kinase/0.455
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.455
1equEQIEstradiol 17-beta-dehydrogenase 11.1.1.620.454
1fx9MJIPhospholipase A2, major isoenzyme3.1.1.40.454
1xp8AGSProtein RecA/0.454
1zptFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.454
2abbFMNPentaerythritol tetranitrate reductase/0.454
2oc4IMHPurine nucleoside phosphorylase2.4.2.10.454
2rg6287Mitogen-activated protein kinase 14/0.454
2xvw9NRSerum albumin/0.454
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.454
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.454
3bv2P38Mitogen-activated protein kinase 14/0.454
3dhcCYKN-acyl homoserine lactonase AiiA3.1.1.810.454
3gcq1BUMitogen-activated protein kinase 14/0.454
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
3k8q22APurine nucleoside phosphorylase2.4.2.10.454
3mb714ICasein kinase II subunit alpha2.7.11.10.454
3zoiM2WIsopenicillin N synthase1.21.3.10.454
4fevPP1Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.454
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
4pd6URINucleoside permease/0.454
4w6z8IDAlcohol dehydrogenase 11.1.1.10.454
4zs2FLUAlpha-ketoglutarate-dependent dioxygenase FTO/0.454
1d6w00RProthrombin3.4.21.50.453
1j7lADPAminoglycoside 3'-phosphotransferase2.7.1.950.453
1jnzFADAdenylylsulfate reductase, subunit A (AprA)/0.453
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.453
2fhnBNIAvidin-related protein 4/5/0.453
2hu2NADC-terminal binding protein 1/0.453
2ji6ADPOxalyl-CoA decarboxylase4.1.1.80.453
3abaFLICytochrome P450/0.453
3biz61EWee1-like protein kinase2.7.10.20.453
3ggs2FDPurine nucleoside phosphorylase2.4.2.10.453
3r1rATPRibonucleoside-diphosphate reductase 1 subunit alpha1.17.4.10.453
3sl2ATPSensor histidine kinase WalK/0.453
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
4ikeADPAdenylate kinase/0.453
4xj43ATCyclic GMP-AMP synthase/0.453
5ax35IDMitogen-activated protein kinase 12.7.11.240.453
1amoFMNNADPH--cytochrome P450 reductase/0.452
1nlmUD1UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase/0.452
1towCRZFatty acid-binding protein, adipocyte/0.452
1x8lOXRRetinol dehydratase/0.452
2balPQAMitogen-activated protein kinase 14/0.452
2c29NAPDihydroflavonol 4-reductase/0.452
2qbuSAHPrecorrin-2 methyltransferase/0.452
2uupLK4UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.452
3ns2PYVAbscisic acid receptor PYL2/0.452
3p74FMNPentaerythritol tetranitrate reductase/0.452
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.452
3vi5M4MHematopoietic prostaglandin D synthase/0.452
3vqsJT1Genome polyprotein/0.452
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.452
4yj2GTPTubulin alpha-1B chain/0.452
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.451
1j7uANPAminoglycoside 3'-phosphotransferase2.7.1.950.451
1ndhFADNADH-cytochrome b5 reductase 31.6.2.20.451
1w19T1P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.451
1zg32HIIsoflavone 4'-O-methyltransferase/0.451
2fznFADBifunctional protein PutA1.5.5.20.451
2ohvNHLGlutamate racemase/0.451
2q1tNADPutative nucleotide sugar epimerase/ dehydratase/0.451
3bbrBHYGlutamate receptor 2/0.451
3crzFADFerredoxin--NADP+ reductase/0.451
3kb6NADD-lactate dehydrogenase/0.451
3nbvANPKetohexokinase/0.451
4bv9NDPKetimine reductase mu-crystallin1.5.1.250.451
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.451
4dpuAGSMevalonate diphosphate decarboxylase/0.451
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.451
4ihjGTPTubulin alpha-1B chain/0.451
4k39SAMAnaerobic sulfatase-maturating enzyme1.8.980.451
4tx9AMZPhosphoribosyl isomerase A/0.451
4v0s2HN3-dehydroquinate dehydratase4.2.1.100.451
1cf2NAPGlyceraldehyde-3-phosphate dehydrogenase/0.450
1dmwHBIPhenylalanine-4-hydroxylase1.14.16.10.450
1mjaCOAHistone acetyltransferase ESA1/0.450
2gr1FADFerredoxin reductase/0.450
2rr1W8RGenome polyprotein/0.450
3b6zCO7Enoyl reductase LovC10.450
3bgbLJGGag-Pol polyprotein3.4.23.160.450
3s43478Protease/0.450
3vmmP0DAlanine--anticapsin ligase/0.450
4a83DXCMajor pollen allergen Bet v 1-A/0.450
4ambDUDPutative glycosyl transferase/0.450
4bkjSTIEpithelial discoidin domain-containing receptor 12.7.10.10.450
4ead0NPThymidine phosphorylase2.4.2.40.450
4jl5ADPAdenylate kinase/0.450
4wbnGTPTubulin alpha-1B chain/0.450
4xgxADPFAD:protein FMN transferase/0.450
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.450
1lkeDOGBilin-binding protein/0.449
1qiqACCIsopenicillin N synthase1.21.3.10.449
1rbyKEUTrifunctional purine biosynthetic protein adenosine-32.1.2.20.449
1xwfADNAdenosylhomocysteinase3.3.1.10.449
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
2ekaSAHDiphthine synthase/0.449
2oapANPType II secretion system protein (GspE-2)/0.449
2qn3F55Glycogen phosphorylase, muscle form2.4.1.10.449
2vcmM11Isopenicillin N synthase1.21.3.10.449
2xlrFADPutative flavin-containing monooxygenase/0.449
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3p9tTCLRepressor/0.449
3qe0GDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.449
3sf6FDAGlutaryl-CoA dehydrogenase/0.449
3tfyCOAN-alpha-acetyltransferase 502.3.10.449
3u9eCOALmo1369 protein/0.449
3vi7CBDHematopoietic prostaglandin D synthase/0.449
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.449
4h4zFADBiphenyl dioxygenase ferredoxin reductase subunit/0.449
4u0sADPAdenosine monophosphate-protein transferase FICD2.7.7.n10.449
5b0oADPFlagellum-specific ATP synthase3.6.3.140.449
5iqfGDPBifunctional AAC/APH2.3.10.449
6ctsCICCitrate synthase, mitochondrial2.3.3.10.449
1cf3FADGlucose oxidase1.1.3.40.448
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.448
1k6tXN1Gag-Pol polyprotein3.4.23.160.448
1nc1MTH5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase3.2.2.90.448
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.448
1uuoBRFDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.448
2db3ANPATP-dependent RNA helicase vasa, isoform A3.6.4.130.448
2e8hSAHDiphthine synthase/0.448
2ou2ACOHistone acetyltransferase KAT5/0.448
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.448
3d84NDPDihydrofolate reductase1.5.1.30.448
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3ox4NADAlcohol dehydrogenase 21.1.1.10.448
3p0fBAUUridine phosphorylase 22.4.2.30.448
3pd2A3SThreonine--tRNA ligase6.1.1.30.448
3q43D66M1 family aminopeptidase3.4.110.448
3r95ACOMccE protein/0.448
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.448
3zdfNADGlyceraldehyde-3-phosphate dehydrogenase/0.448
4a6bQG8Gag-Pol polyprotein3.4.23.160.448
4b4vL34Bifunctional protein FolD/0.448
4bcsBTNAvidin-related protein 4/5/0.448
4e5yNDPGDP-L-fucose synthase1.1.1.2710.448
4gyy12VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.448
4mka2AYGenome polyprotein2.7.7.480.448
4o4iGTPTubulin alpha-1B chain/0.448
4oznATPAmmonium transporter/0.448
4paoGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.448
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.448
4xrgNADHomospermidine synthase2.5.1.440.448
4y8wSTRSteroid 21-hydroxylase/0.448
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.448
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.448
5cb5APRO-acetyl-ADP-ribose deacetylase/0.448
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.447
1cs4FOKAdenylate cyclase type 2/0.447
1cs4FOKAdenylate cyclase type 5/0.447
1jnrFADAdenylylsulfate reductase, subunit A (AprA)/0.447
1kr2TADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.447
1lbm137N-(5'-phosphoribosyl)anthranilate isomerase5.3.1.240.447
1mczRMNBenzoylformate decarboxylase4.1.1.70.447
1mueCDDProthrombin3.4.21.50.447
2a94AP0L-lactate dehydrogenase1.1.1.270.447
2dgnDOIAdenylosuccinate synthetase isozyme 1/0.447
2iviACWIsopenicillin N synthase1.21.3.10.447
2zjuIM4Acetylcholine-binding protein/0.447
2zsiGA4Gibberellin receptor GID1A30.447
3ihgVAKAklavinone 12-hydroxylase RdmE/0.447
3oibFDAPutative acyl-CoA dehydrogenase/0.447
3qczANPDihydrofolate synthase/folylpolyglutamate synthase/0.447
3qftNAPNADPH--cytochrome P450 reductase/0.447
3r5yF42Uncharacterized protein/0.447
4d6qPD2Lysine-specific demethylase 4D1.14.110.447
4jk3NADUncharacterized protein/0.447
4ri1ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase2.3.1.2020.447
1h73ANPHomoserine kinase2.7.1.390.446
1hncGDNGlutathione S-transferase Mu 22.5.1.180.446
1kzkJE2Gag-Pol polyprotein3.4.23.160.446
1mjbACOHistone acetyltransferase ESA1/0.446
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
1t13INI6,7-dimethyl-8-ribityllumazine synthase 2/0.446
1w1wAGSStructural maintenance of chromosomes protein 1/0.446
1xe65FPPlasmepsin-23.4.23.390.446
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.446
2c27ACOMycothiol acetyltransferase2.3.1.1890.446
2pdaTPPPyruvate synthase/0.446
2w6zL21Biotin carboxylase6.3.4.140.446
2xvu9DNSerum albumin/0.446
2y0mACOHistone acetyltransferase KAT8/0.446
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.446
3dhbC6LN-acyl homoserine lactonase AiiA3.1.1.810.446
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
3iaaTYDCalG2/0.446
3lmhADPMyosin heavy chain kinase A2.7.11.70.446
3lnc5GPGuanylate kinase/0.446
3oadLPORenin3.4.23.150.446
3to6LYS_CMCHistone acetyltransferase ESA1/0.446
3zhsTD6Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.446
4b68NAPL-ornithine N(5)-monooxygenase/0.446
4d9eLCSD-cysteine desulfhydrase/0.446
4hnc0UTMandelate racemase/0.446
4i13FOLDihydrofolate reductase1.5.1.30.446
4ohwATPProtein clpf-1/0.446
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.446
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.446
4zolGTPTubulin alpha-1B chain/0.446
5k2aZMAAdenosine receptor A2a/0.446
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.445
1ia1NDPDihydrofolate reductase1.5.1.30.445
1j7kATPHolliday junction ATP-dependent DNA helicase RuvB/0.445
1kqoDNDNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.445
1rfvADPPyridoxal kinase2.7.1.350.445
2a7r5GPGMP reductase 2/0.445
2a87FADThioredoxin reductase1.8.1.90.445
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
2h94FADLysine-specific histone demethylase 1A10.445
2oegUPGUDP-glucose pyrophosphorylase/0.445
2ptfFMNUncharacterized protein MTH_863/0.445
2qlnF59Glycogen phosphorylase, muscle form2.4.1.10.445
2wedPP6Penicillopepsin-13.4.23.200.445
2x3nFADProbable FAD-dependent monooxygenase/0.445
3akm11DFatty acid-binding protein, intestinal/0.445
3c3eFO12-phospho-L-lactate transferase/0.445
3cgbCOACoenzyme A disulfide reductase/0.445
3clxX22E3 ubiquitin-protein ligase XIAP6.3.20.445
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3elm24FCollagenase 33.4.240.445
3iktNADRedox-sensing transcriptional repressor Rex/0.445
3kr6UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.445
3litE15Protease/0.445
3lu8IQXSerum albumin/0.445
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.445
3pdnSFGHistone-lysine N-methyltransferase SMYD32.1.1.430.445
3rupADPBiotin carboxylase6.3.4.140.445
3t94MTAS-methyl-5'-thioadenosine phosphorylase/0.445
3zvmADPBifunctional polynucleotide phosphatase/kinase2.7.1.780.445
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.445
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4frs0V6Beta-secretase 13.4.23.460.445
4fxfATPPyruvate kinase PKM2.7.1.400.445
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
4kp71UQ1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic1.1.1.2670.445
4panGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.445
4wdfA2P2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.445
4wfr2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.445
4y380A9Endothiapepsin3.4.23.220.445
8catNDPCatalase1.11.1.60.445
1a9sNOSPurine nucleoside phosphorylase2.4.2.10.444
1e1lNAPNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.444
1eioGCHGastrotropin/0.444
1f06NDPMeso-diaminopimelate D-dehydrogenase1.4.1.160.444
1i24UPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.444
1pqc444Oxysterols receptor LXR-beta/0.444
1wur8DGGTP cyclohydrolase 1/0.444
2c42TPPPyruvate synthase/0.444
2c92TP66,7-dimethyl-8-ribityllumazine synthase2.5.1.780.444
2cbrA80Cellular retinoic acid-binding protein 1/0.444
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.444
2cn0F25Prothrombin3.4.21.50.444
2gcgNDPGlyoxylate reductase/hydroxypyruvate reductase1.1.1.790.444
2i0aMUIProtease/0.444
2qfvNAPIsocitrate dehydrogenase [NADP], mitochondrial1.1.1.420.444
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.444
3autNAIGlucose 1-dehydrogenase 41.1.1.470.444
3h3fNAIL-lactate dehydrogenase A chain1.1.1.270.444
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.444
3nbwTR4Ketohexokinase/0.444
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3rinI2OMitogen-activated protein kinase 14/0.444
3s41S41Glucokinase2.7.1.20.444
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.444
4bfzZVZPantothenate kinase2.7.1.330.444
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.444
4euc0RQSuccinyl-CoA:acetate CoA-transferase/0.444
4iah1DXAlr2278 protein/0.444
4plpNADHomospermidine synthase2.5.1.440.444
4ts7ADPPurine phosphoribosyltransferase (GpT-1)/0.444
4z875GPInosine-5'-monophosphate dehydrogenase/0.444
1a8rGTPGTP cyclohydrolase 13.5.4.160.443
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.443
1fxuGU7Purine nucleoside phosphorylase2.4.2.10.443
1l8qADPChromosomal replication initiator protein DnaA/0.443
1pdhFASp-hydroxybenzoate hydroxylase/0.443
1q6nP90Tyrosine-protein phosphatase non-receptor type 13.1.3.480.443
1qvnFRIInterleukin-2/0.443
1t85CAMCamphor 5-monooxygenase1.14.15.10.443
1zmdNAIDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.443
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.443
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2fjaFADAdenylylsulfate reductase, subunit A (AprA)/0.443
2gjlFMNNitronate monooxygenase1.13.12.160.443
2jkvNAP6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.443
2nnqT4BFatty acid-binding protein, adipocyte/0.443
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.443
2qujTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.443
2vceU2FUDP-glycosyltransferase 72B1/0.443
2vwx7X4Ephrin type-B receptor 42.7.10.10.443
3ac1KZITyrosine-protein kinase Lck2.7.10.20.443
3gwdFADCyclohexanone monooxygenase/0.443
3lsiFADPyranose 2-oxidase/0.443
3n7uNADFormate dehydrogenase, chloroplastic/mitochondrial/0.443
3nu5478Gag-Pol polyprotein3.4.23.160.443
3ukuC69Actin-related protein 3/0.443
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3vx4ATPPutative ABC transporter, ATP-binding protein ComA/0.443
4b4w9L9Bifunctional protein FolD/0.443
4ck2NVUIntegrase/0.443
4gl4NAIAlcohol dehydrogenase class-3/0.443
4k28NADShikimate dehydrogenase family protein/0.443
4mv8ACPBiotin carboxylase6.3.4.140.443
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.443
4nieNBHNuclear receptor ROR-gamma/0.443
4nu0AP5Adenylate kinase/0.443
4opiFDAConserved Archaeal protein/0.443
4rww2BALmo2692 protein/0.443
4tl8AGSCircadian clock protein kinase KaiC2.7.11.10.443
4tuvCPZCytochrome P450 1191.140.443
5kczNAJAlcohol dehydrogenase E chain1.1.1.10.443
1f3pFADFerredoxin reductase/0.442
1gjvAGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial2.7.11.40.442
1k7fIAVTryptophan synthase alpha chain/0.442
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.442
1vf3GDNGlutathione S-transferase 32.5.1.180.442
1zdfUPGGlycogenin-12.4.1.1860.442
2a5kAZPReplicase polyprotein 1ab3.4.220.442
2a9z26AAdenosine kinase2.7.1.200.442
2ahrNAPPyrroline-5-carboxylate reductase/0.442
2ggsNDPdTDP-4-dehydrorhamnose reductase/0.442
2hah3TLPOL protein/0.442
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.442
2ql6ADPNicotinamide riboside kinase 1/0.442
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.442
2wo7ASVIsopenicillin N synthase1.21.3.10.442
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.442
2xyuQ9GEphrin type-A receptor 42.7.10.10.442
2zjwREFCasein kinase II subunit alpha2.7.11.10.442
3d2mCOAAmino-acid acetyltransferase/0.442
3d8bADPFidgetin-like protein 13.6.40.442
3i1y33NBifunctional epoxide hydrolase 23.3.2.100.442
3oev3OEProteasome subunit beta type-53.4.25.10.442
3oev3OEProteasome subunit beta type-63.4.25.10.442
3p5pA3CTaxadiene synthase4.2.3.170.442
3qeoLLTDeoxycytidine kinase2.7.1.740.442
3t3c017Gag-Pol polyprotein3.4.23.160.442
3w0iO11Vitamin D3 receptor/0.442
3zcsCAWGlycogen phosphorylase, muscle form2.4.1.10.442
4b6r3DQ3-dehydroquinate dehydratase4.2.1.100.442
4biwANPSensor histidine kinase CpxA/0.442
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.442
4i8x6P3L-lactate dehydrogenase A chain1.1.1.270.442
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.442
4tv9GTPTubulin alpha-1B chain/0.442
5e8xSTUTGF-beta receptor type-12.7.11.300.442
5hwpCOAHydroxymethylglutaryl-CoA synthase/0.442
5jtbZMAAdenosine receptor A2a/0.442
1b2lNDCAlcohol dehydrogenase1.1.1.10.441
1ftlDNQGlutamate receptor 2/0.441
1i59ANPChemotaxis protein CheA2.7.13.30.441
1kvkATPMevalonate kinase2.7.1.360.441
1me7MOAInosine-5'-monophosphate dehydrogenase/0.441
1qf5RPLAdenylosuccinate synthetase/0.441
1tj2FADBifunctional protein PutA1.5.5.20.441
1u2yGOXPancreatic alpha-amylase/0.441
1umcTDP2-oxoisovalerate dehydrogenase subunit alpha1.2.4.40.441
1umcTDP2-oxoisovalerate dehydrogenase subunit beta1.2.4.40.441
2bfqAR6[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.441
2bu9HFVIsopenicillin N synthase1.21.3.10.441
2hb8MVDVitamin D3 receptor/0.441
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.441
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.441
2ojg19AMitogen-activated protein kinase 12.7.11.240.441
2qu5276Vascular endothelial growth factor receptor 22.7.10.10.441
2vtdLKMUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.441
3cr0809Wee1-like protein kinase2.7.10.20.441
3ekuCY9Actin-5C/0.441
3fklFKLMitogen-activated protein kinase 14/0.441
3hub469Mitogen-activated protein kinase 14/0.441
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.441
3mpt1GKMitogen-activated protein kinase 14/0.441
3sp9IL2Peroxisome proliferator-activated receptor delta/0.441
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.441
3v4tUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.441
3vjoANPEpidermal growth factor receptor2.7.10.10.441
3wtkTH4Acetylcholine-binding protein/0.441
4bqyFNTEgl nine homolog 1/0.441
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
4f6rGDPTubulin beta chain/0.441
4f9fGDPPutative glycosyltransferase/0.441
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.441
4iji99TGlutathione S-transferase-like protein YibF/0.441
4k6fNAPPutative Acetoacetyl-CoA reductase/0.441
4kwi1TJReductase homolog/0.441
4wudANPDNA gyrase subunit B/0.441
4xq9NADHomospermidine synthase2.5.1.440.441
5e8wSTUTGF-beta receptor type-12.7.11.300.441
5k2cZMAAdenosine receptor A2a/0.441
1cg3IMOAdenylosuccinate synthetase/0.440
1fm4DXCMajor pollen allergen Bet v 1-L/0.440
1ny2ARG_PRO_PRO_GLYProthrombin3.4.21.50.440
1qk35GPHypoxanthine-guanine-xanthine phosphoribosyltransferase2.4.2.220.440
1tl7FOKAdenylate cyclase type 2/0.440
1tl7FOKAdenylate cyclase type 5/0.440
1uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.440
1xdpATPPolyphosphate kinase/0.440
1zemNADXylitol dehydrogenase/0.440
2c2aADPSensor histidine kinase/0.440
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
2daaDCSD-alanine aminotransferase2.6.1.210.440
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.440
2v13C40Renin3.4.23.150.440
2v1aFMNNPH1-1/0.440
2xvfFADPutative flavin-containing monooxygenase/0.440
2zazGK1Mitogen-activated protein kinase 14/0.440
3a3gDLZLumazine protein/0.440
3cgdCOACoenzyme A disulfide reductase/0.440
3cz7ACOHistone acetyltransferase RTT1092.3.1.480.440
3dmeFADPutative conserved exported protein/0.440
3h3sH15Collagen type IV alpha-3-binding protein/0.440
3l6jZ90Alr2278 protein/0.440
3mt817TGlycogen phosphorylase, muscle form2.4.1.10.440
3n87N873-dehydroquinate dehydratase4.2.1.100.440
3own3OWRenin3.4.23.150.440
3q33ACOHistone acetyltransferase RTT1092.3.1.480.440
3r83Z14Cyclin-dependent kinase 22.7.11.220.440
3uayADNPurine nucleoside phosphorylase DeoD-type/0.440
3zkyWT4Isopenicillin N synthase1.21.3.10.440
4ag7COAGlucosamine 6-phosphate N-acetyltransferase/0.440
4h4uNDPBiphenyl dioxygenase ferredoxin reductase subunit/0.440
4h8004TAldehyde dehydrogenase, dimeric NADP-preferring/0.440
4kgkGTPUncharacterized protein/0.440
4kiq1RAMitogen-activated protein kinase 14/0.440
4n6hEJ4Delta-type opioid receptor/0.440
4u0mATPCyclic GMP-AMP synthase/0.440
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.440
4z0g5GPInosine-5'-monophosphate dehydrogenase/0.440