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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4locBTNPyruvate carboxylase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4locBTNPyruvate carboxylase/1.000
4mfeBTNPyruvate carboxylase/0.571
2jb4A14Isopenicillin N synthase1.21.3.10.570
3zkyWT4Isopenicillin N synthase1.21.3.10.562
4bb3KKAIsopenicillin N synthase1.21.3.10.553
1bk0ACVIsopenicillin N synthase1.21.3.10.542
2bu9HFVIsopenicillin N synthase1.21.3.10.541
1obnASVIsopenicillin N synthase1.21.3.10.540
2iviACWIsopenicillin N synthase1.21.3.10.526
3zoiM2WIsopenicillin N synthase1.21.3.10.524
1hb3SCVIsopenicillin N synthase1.21.3.10.521
3eksCY9Actin-5C/0.516
1qiqACCIsopenicillin N synthase1.21.3.10.501
1uzwCDHIsopenicillin N synthase1.21.3.10.498
1hb1OCVIsopenicillin N synthase1.21.3.10.497
2rr1W8RGenome polyprotein/0.496
3uceNDPDehydrogenase/0.496
4cdmFO1Deoxyribodipyrimidine photolyase/0.496
5hs1VORLanosterol 14-alpha demethylase/0.496
1pqc444Oxysterols receptor LXR-beta/0.494
1qjfACSIsopenicillin N synthase1.21.3.10.494
2g1r3IGRenin3.4.23.150.493
2vbdV10Isopenicillin N synthase1.21.3.10.493
2rm2W43Genome polyprotein/0.492
2ym1FADPhenylacetone monooxygenase1.14.13.920.492
2y6fM9FIsopenicillin N synthase1.21.3.10.491
3r9uFADThioredoxin reductase/0.491
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.490
2npxNADNADH peroxidase1.11.1.10.490
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.490
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.489
5fm7ADPRuvB-like helicase/0.489
3aygHQONitric oxide reductase/0.488
4a6rTA8Probable aminotransferase/0.486
2wo7ASVIsopenicillin N synthase1.21.3.10.485
4yddMD1DMSO reductase family type II enzyme, molybdopterin subunit/0.485
1kvkATPMevalonate kinase2.7.1.360.484
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.484
2rs1W84Genome polyprotein/0.484
1oc1ASVIsopenicillin N synthase1.21.3.10.482
2y60M8FIsopenicillin N synthase1.21.3.10.482
4bakM67Prothrombin3.4.21.50.481
4bamMM9Prothrombin3.4.21.50.481
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.481
1h22E10Acetylcholinesterase3.1.1.70.480
1ju2FAD(R)-mandelonitrile lyase 24.1.2.100.480
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.479
2zfr46UProthrombin3.4.21.50.479
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.479
1vkgCRIHistone deacetylase 83.5.1.980.478
2vcmM11Isopenicillin N synthase1.21.3.10.478
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.478
3f63GTXGlutathione transferase GST1-4/0.478
4da7AC2Purine nucleoside phosphorylase DeoD-type2.4.2.10.478
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.478
4uugPXGBranched-chain amino acid aminotransferase, putative/0.477
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.477
1fduNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.476
1ppjANYCytochrome b/0.476
3br3ETHTH-type transcriptional regulator QacR/0.476
3w6uNAP6-phosphogluconate dehydrogenase, NAD-binding protein/0.476
1hrvSDZGenome polyprotein/0.475
1x27ASP_TYR_VAL_HIS_PTRTyrosine-protein kinase Lck2.7.10.20.475
2zcvNDPQuinone oxidoreductase 21.6.5.20.475
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.475
3zkuHCVIsopenicillin N synthase1.21.3.10.475
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.475
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.474
3bbrBHYGlutamate receptor 2/0.474
5jy1NADPutative short-chain dehydrogenase/reductase/0.474
1blzACVIsopenicillin N synthase1.21.3.10.473
1udyFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.473
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.473
3uzzASD3-oxo-5-beta-steroid 4-dehydrogenase/0.473
3v0p4GWHisto-blood group ABO system transferase/0.473
3vdqNAD3-hydroxybutyrate dehydrogenase/0.473
1x1dSAHC-20 methyltransferase/0.472
1zw9H64ATP-dependent molecular chaperone HSP82/0.472
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.472
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.472
1xddAAYIntegrin alpha-L/0.471
3p62FMNPentaerythritol tetranitrate reductase/0.471
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.471
1cjkFOKAdenylate cyclase type 2/0.470
1cjkFOKAdenylate cyclase type 5/0.470
3koyZ97D-ornithine 4,5-aminomutase subunit beta/0.470
4baoMVFProthrombin3.4.21.50.470
4weqNAPNAD-dependent dehydrogenase/0.470
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.469
1ndhFADNADH-cytochrome b5 reductase 31.6.2.20.469
1ta6177Prothrombin3.4.21.50.469
1w06W05Isopenicillin N synthase1.21.3.10.469
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.469
2vbpVB1Isopenicillin N synthase1.21.3.10.469
3b6zCO7Enoyl reductase LovC10.469
3b70NAPEnoyl reductase LovC10.469
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.469
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.469
4baqM4ZProthrombin3.4.21.50.469
1qorNDPQuinone oxidoreductase 1/0.468
2y4gTIRTamL/0.468
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.468
3toxNAPPutative oxidoreductase/0.468
4loi1YCStimulator of interferon genes protein/0.468
4lxk1YTBeta-secretase 13.4.23.460.468
4xguADPPutative pachytene checkpoint protein 2/0.468
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
2y3rTRKTamL/0.467
3arvSAUChitinase A/0.467
3s55NADPutative short-chain dehydrogenase/reductase/0.467
1icpFMN12-oxophytodienoate reductase 11.3.1.420.466
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.466
2x9dITCTetracycline repressor protein class D/0.466
4hy6FJ1Heat shock protein HSP 90-alpha/0.466
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.466
4q71FADBifunctional protein PutA/0.466
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.466
1lf2R37Plasmepsin-23.4.23.390.465
1qrpHH0Pepsin A-43.4.23.10.465
1u65CP0Acetylcholinesterase3.1.1.70.465
2c29NAPDihydroflavonol 4-reductase/0.465
2ifaFMNUncharacterized protein/0.465
3dv5BAVBeta-secretase 13.4.23.460.465
3p3c3P3UDP-3-O-acyl-N-acetylglucosamine deacetylase/0.465
3zbsOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.465
4yryFADGlutamate synthase, beta subunit/0.465
2ignFADPyranose 2-oxidase/0.464
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.464
3isjA8DPantothenate synthetase6.3.2.10.464
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.464
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.464
3uaxNOSPurine nucleoside phosphorylase DeoD-type/0.464
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.464
4n3l2FNProthrombin3.4.21.50.464
1ja0FADNADPH--cytochrome P450 reductase/0.463
1mueCDDProthrombin3.4.21.50.463
1x1bSAHC-20 methyltransferase/0.463
2cwfNDPDelta(1)-pyrroline-2-carboxylate/Delta(1)-piperideine-2-carboxylate reductase/0.463
2j3qTFLAcetylcholinesterase3.1.1.70.463
2ou2ACOHistone acetyltransferase KAT5/0.463
2r04W71Genome polyprotein/0.463
3nsh957Beta-secretase 13.4.23.460.463
4i0i957Beta-secretase 13.4.23.460.463
4kbyC2EStimulator of interferon genes protein/0.463
4lcjNADC-terminal-binding protein 2/0.463
1eveE20Acetylcholinesterase3.1.1.70.462
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.462
2anmCDOProthrombin3.4.21.50.462
2fhnBNIAvidin-related protein 4/5/0.462
2ikuLIYRenin3.4.23.150.462
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.462
2xviFADPutative flavin-containing monooxygenase/0.462
4idgNADPutative UDP-glucose 4-epimerase/0.462
1obbNADAlpha-glucosidase3.2.1.200.461
2g1s4IGRenin3.4.23.150.461
2jl1NAPTriphenylmethane reductase/0.461
2p5uNADUDP-glucose 4-epimerase/0.461
2x06NADL-sulfolactate dehydrogenase/0.461
2xupTZ5Acetylcholinesterase3.1.1.70.461
2yxuATPPyridoxal kinase2.7.1.350.461
3go4SAHUncharacterized protein/0.461
4bfwZVWPantothenate kinase2.7.1.330.461
4nd4NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.461
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.461
1r2jFADFkbI/0.460
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.460
2x8gFADThioredoxin glutathione reductase/0.460
3cavCI23-oxo-5-beta-steroid 4-dehydrogenase/0.460
3g5hYTTMycocyclosin synthase1.14.21.90.460
3iocA5DPantothenate synthetase6.3.2.10.460
3zc5W9ZHepatocyte growth factor receptor2.7.10.10.460
4ambDUDPutative glycosyl transferase/0.460
4m4922YL-lactate dehydrogenase A chain1.1.1.270.460
1bwsNDPGDP-L-fucose synthase/0.459
1dbvNADGlyceraldehyde-3-phosphate dehydrogenase/0.459
1fy7COAHistone acetyltransferase ESA1/0.459
1h74ADPHomoserine kinase2.7.1.390.459
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.459
1ja0FMNNADPH--cytochrome P450 reductase/0.459
1n2iPAJPantothenate synthetase6.3.2.10.459
1opmIYGPeptidyl-glycine alpha-amidating monooxygenase1.14.17.30.459
1y7lASN_LEU_ASN_ILECysteine synthase2.5.1.470.459
2v6gNAP3-oxo-Delta(4,5)-steroid 5-beta-reductase/0.459
2yk2YJXHeat shock protein HSP 90-alpha/0.459
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.459
3c1kT15Prothrombin3.4.21.50.459
3hz5Z64Heat shock protein HSP 90-alpha/0.459
3ko8NADNAD-dependent epimerase/dehydratase/0.459
3tlc7MDMicrocin C7 self-immunity protein MccF/0.459
4dfg0JVGag-Pol polyprotein3.4.23.160.459
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.459
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.459
1lf3EH5Plasmepsin-23.4.23.390.458
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.458
1n5dNDPCarbonyl reductase [NADPH] 1/0.458
1rfuADPPyridoxal kinase2.7.1.350.458
1txtCAAHMG-CoA synthase/0.458
2g226IGRenin3.4.23.150.458
2givACOHistone acetyltransferase KAT8/0.458
3h3sH15Collagen type IV alpha-3-binding protein/0.458
3p5pA3CTaxadiene synthase4.2.3.170.458
3qgf46FGenome polyprotein2.7.7.480.458
3zcsCAWGlycogen phosphorylase, muscle form2.4.1.10.458
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.458
5stdUNNScytalone dehydratase4.2.1.940.458
1rzuADPGlycogen synthase 12.4.1.210.457
1ve3SAMUncharacterized protein/0.457
2c20NADUDP-glucose 4-epimerase/0.457
2e99B08Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.457
2gv8NDPThiol-specific monooxygenase1.14.130.457
2zevB71Geranylgeranyl pyrophosphate synthase/0.457
3kpbSAMUncharacterized protein MJ0100/0.457
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.457
4da6GA2Purine nucleoside phosphorylase DeoD-type2.4.2.10.457
4eb7PLPCysteine desulfurase IscS 2/0.457
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.457
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.457
5a9sNAPPutative dehydrogenase/0.457
6stdMS2Scytalone dehydratase4.2.1.940.457
1h60STRPentaerythritol tetranitrate reductase/0.456
1odnAPVIsopenicillin N synthase1.21.3.10.456
2g247IGRenin3.4.23.150.456
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.456
2g8yNADHydroxycarboxylate dehydrogenase B/0.456
2gpjFADSiderophore-interacting protein/0.456
2r8pT6FTransketolase 1/0.456
2rqfJH3Hemolymph juvenile hormone binding protein/0.456
2xpwOTCTetracycline repressor protein class D/0.456
2y5s78HDihydropteroate synthase/0.456
2yq92AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.456
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.456
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
3fhxPLPPyridoxal kinase2.7.1.350.456
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.456
3lpjZ75Beta-secretase 13.4.23.460.456
4b63NAPL-ornithine N(5)-monooxygenase/0.456
4banM6SProthrombin3.4.21.50.456
4bj9UHBTankyrase-22.4.2.300.456
4m9aFDAAcyl-CoA dehydrogenase/0.456
4nh82LCHeat shock protein HSP 90-alpha/0.456
4oztP1AEcdysone receptor, putative/0.456
4psbGA3Cytokinin-specific binding protein/0.456
1pq944BOxysterols receptor LXR-beta/0.455
1stdBFSScytalone dehydratase4.2.1.940.455
1t4u81AProthrombin3.4.21.50.455
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.455
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.455
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3qwbNDPProbable quinone oxidoreductase1.6.5.50.455
3r96ACOMccE protein/0.455
3zxzKRWHepatocyte growth factor receptor2.7.10.10.455
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.455
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.455
4g3jVNTLanosterol 14-alpha-demethylase/0.455
4qzuRTLRetinol-binding protein 2/0.455
4twrNADNAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase/0.455
5c3aURMHisto-blood group ABO system transferase/0.455
1cs4FOKAdenylate cyclase type 2/0.454
1cs4FOKAdenylate cyclase type 5/0.454
1dorFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.10.454
1kkq471Peroxisome proliferator-activated receptor alpha/0.454
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.454
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.454
2qimZEAClass 10 plant pathogenesis-related protein/0.454
2wesFADTryptophan 5-halogenase/0.454
2xveFADPutative flavin-containing monooxygenase/0.454
4eudCOASuccinyl-CoA:acetate CoA-transferase/0.454
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.454
4l4xNDPAmphI/0.454
4mhtSAHModification methylase HhaI2.1.1.370.454
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.454
5kgpACOPredicted acetyltransferase/0.454
7stdCRPScytalone dehydratase4.2.1.940.454
3sn6P0GBeta-2 adrenergic receptor/0.454
1jueFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.10.453
1nahNADUDP-glucose 4-epimerase5.1.3.20.453
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.453
1sdwIYTPeptidyl-glycine alpha-amidating monooxygenase1.14.17.30.453
2r8oT5XTransketolase 1/0.453
2xuhTZ4Acetylcholinesterase3.1.1.70.453
3bk2U5PRibonuclease J/0.453
3fhyATPPyridoxal kinase2.7.1.350.453
3h0bB35Beta-secretase 13.4.23.460.453
4lxa1YSBeta-secretase 13.4.23.460.453
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.452
1m78NDPDihydrofolate reductase1.5.1.30.452
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.452
1rfvADPPyridoxal kinase2.7.1.350.452
1tysDHFThymidylate synthase/0.452
2q1tNADPutative nucleotide sugar epimerase/ dehydratase/0.452
2vkeTACTetracycline repressor protein class D/0.452
2wdzNADGalactitol dehydrogenase/0.452
3ekuCY9Actin-5C/0.452
3eq02TSProthrombin3.4.21.50.452
3gwfNAPCyclohexanone monooxygenase/0.452
3h59H59Genome polyprotein2.7.7.480.452
3inxJZCHeat shock protein HSP 90-alpha/0.452
3iqiASN_GLU_ASN_ILECysteine synthase2.5.1.470.452
3tp0FO5HTH-type transcriptional regulator EthR/0.452
4bftZVTPantothenate kinase2.7.1.330.452
4bfxZVXPantothenate kinase2.7.1.330.452
4ef8FMNDihydroorotate dehydrogenase (fumarate)/0.452
4gz612VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.452
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.452
4rvnCOAPhenylacetate-coenzyme A ligase/0.452
1fxsNAPGDP-L-fucose synthase/0.451
1snyNAPLD36273p/0.451
1xe55FEPlasmepsin-23.4.23.390.451
2g1o2IGRenin3.4.23.150.451
2xfyACXBeta-amylase3.2.1.20.451
2zevIPEGeranylgeranyl pyrophosphate synthase/0.451
3aosJH2Hemolymph juvenile hormone binding protein/0.451
3n0hTOPDihydrofolate reductase1.5.1.30.451
3qfrFMNNADPH--cytochrome P450 reductase/0.451
3tjzGNPADP-ribosylation factor 1/0.451
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.451
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.451
4df2FMNNADPH dehydrogenase/0.451
4m83ERYOleandomycin glycosyltransferase2.4.10.451
4n3cUD1UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.451
5a65TPPThiamine-triphosphatase3.6.1.280.451
1kphSAHCyclopropane mycolic acid synthase 12.1.1.790.450
1pr0NOSPurine nucleoside phosphorylase DeoD-type/0.450
1qyvNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.450
2a94AP0L-lactate dehydrogenase1.1.1.270.450
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.450
2gd2CAAProbable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )/0.450
2vceU2FUDP-glycosyltransferase 72B1/0.450
2xlpFADPutative flavin-containing monooxygenase/0.450
3da24MDCarbonic anhydrase 134.2.1.10.450
3ey4352Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
3imgBZ2Pantothenate synthetase6.3.2.10.450
3ixp834Ecdysone receptor/0.450
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.450
3uyk0CXProbable NDP-rhamnosyltransferase/0.450
4b7zQ4QAcetylcholinesterase3.1.1.70.450
4d89BXDBeta-secretase 13.4.23.460.450
4da0GNGPurine nucleoside phosphorylase DeoD-type2.4.2.10.450
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
4ubtCOASteroid 3-ketoacyl-CoA thiolase/0.450
1knrFADL-aspartate oxidase1.4.3.160.449
1nzdUPGDNA beta-glucosyltransferase/0.449
1odcA8BAcetylcholinesterase3.1.1.70.449
1yvfPH7Polyprotein/0.449
2a2cADPN-acetylgalactosamine kinase2.7.1.1570.449
2ol4JPNEnoyl-ACP reductase/0.449
2pksG44Prothrombin3.4.21.50.449
2ykiYKIHeat shock protein HSP 90-alpha/0.449
2yutNAPPutative short-chain oxidoreductase/0.449
3elbC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.449
3gw9VNILanosterol 14-alpha-demethylase/0.449
3i8p8403-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.449
3jzdNADMaleylacetate reductase/0.449
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.449
3tm5SFGUncharacterized protein/0.449
4da8BG2Purine nucleoside phosphorylase DeoD-type2.4.2.10.449
4dxlC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.449
4fhj0TZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4hcy0YNTransketolase/0.449
4ttjFMCPurine nucleoside phosphorylase DeoD-type/0.449
5c1mCLRMu-type opioid receptor/0.449
1aiqCB3Thymidylate synthase/0.448
1gjvAGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial2.7.11.40.448
1trgCB3Thymidylate synthase/0.448
1x8lOXRRetinol dehydratase/0.448
1xe65FPPlasmepsin-23.4.23.390.448
2dteNAIGlucose 1-dehydrogenase related protein/0.448
2e07SAHDiphthine synthase/0.448
2fr1NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/0.448
2gd6ACOProbable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )/0.448
2o23NAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.448
2pbzATPUncharacterized protein/0.448
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
2trtTACTetracycline repressor protein class D/0.448
2uuvFADAlkyldihydroxyacetonephosphate synthase2.5.1.260.448
2v59LZKBiotin carboxylase6.3.4.140.448
2vqbFADPutative flavin-containing monooxygenase/0.448
2wetFADTryptophan 5-halogenase/0.448
2yjxYJXHeat shock protein HSP 90-alpha/0.448
3dux64UProthrombin3.4.21.50.448
3f90FMNFlavodoxin/0.448
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.448
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3o6o94MHeat shock protein 83/0.448
3uayADNPurine nucleoside phosphorylase DeoD-type/0.448
3vx4ATPPutative ABC transporter, ATP-binding protein ComA/0.448
4fco0U4Beta-secretase 13.4.23.460.448
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
4hh4SAHCcbJ/0.448
4na4A1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.448
4ubuCOASteroid 3-ketoacyl-CoA thiolase/0.448
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.448
5cmx0G6Prothrombin3.4.21.50.448
5jlaNADPutative short-chain dehydrogenase/reductase/0.448
1pr4MTPPurine nucleoside phosphorylase DeoD-type/0.447
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
2gfxPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.447
2gz7D3FOrf1a polyprotein/0.447
2qirCOAAminoglycoside 6-N-acetyltransferase type Ib11/0.447
2y3sTIRTamL/0.447
2ykeYKEHeat shock protein HSP 90-alpha/0.447
2zhe13UProthrombin3.4.21.50.447
2zvbSAHPrecorrin-3 C17-methyltransferase/0.447
3gqvNAPEnoyl reductase LovC10.447
3kp0Z98D-ornithine 4,5-aminomutase subunit beta/0.447
3lpkZ76Beta-secretase 13.4.23.460.447
3mj4URMUDP-galactopyranose mutase/0.447
3ohh3HHBeta-secretase 13.4.23.460.447
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.447
3swqEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.447
3w8eNAD3-hydroxybutyrate dehydrogenase/0.447
5ao1DG3Deoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.447
1kceCB3Thymidylate synthase/0.446
1mv8GDXGDP-mannose 6-dehydrogenase1.1.1.1320.446
1t2cNAIL-lactate dehydrogenase1.1.1.270.446
1yplRA8Prothrombin3.4.21.50.446
2a5hSAML-lysine 2,3-aminomutase5.4.3.20.446
2ahrNAPPyrroline-5-carboxylate reductase/0.446
2ok7FADFerredoxin--NADP reductase, apicoplast/0.446
2p4j23IBeta-secretase 13.4.23.460.446
2r2mI50Prothrombin3.4.21.50.446
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
3cotSTR3-oxo-5-beta-steroid 4-dehydrogenase/0.446
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3o8hO8HHTH-type transcriptional regulator EthR/0.446
3qj0QI3Botulinum neurotoxin type A3.4.24.690.446
3qrwNDPPutative ketoacyl reductase1.3.10.446
3tdl11DSerum albumin/0.446
3wagTYDGlycosyltransferase/0.446
4pd6URINucleoside permease/0.446
5dbfNDPIridoid synthase1.3.1.990.446
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.445
1mczRMNBenzoylformate decarboxylase4.1.1.70.445
1qbqHFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.445
1qbqHFPProtein farnesyltransferase subunit beta2.5.1.580.445
1szgFNSCytochrome b2, mitochondrial1.1.2.30.445
1zgi382Prothrombin3.4.21.50.445
2am22LGUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.445
2fonFADAcyl-coenzyme A oxidase/0.445
2vqbNAPPutative flavin-containing monooxygenase/0.445
2xvhNAPPutative flavin-containing monooxygenase/0.445
2yvwEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.445
2zfnACOHistone acetyltransferase RTT1092.3.1.480.445
2zfp19UProthrombin3.4.21.50.445
2zgx29UProthrombin3.4.21.50.445
3coy53HPantothenate synthetase6.3.2.10.445
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.445
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3mjrAC2Deoxycytidine kinase2.7.1.740.445
3oqkS52Renin3.4.23.150.445
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.445
4a32MYAGlycylpeptide N-tetradecanoyltransferase/0.445
4a87NARMajor pollen allergen Bet v 1-A/0.445
4bkqNAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.445
4bvnP32Beta-1 adrenergic receptor/0.445
4do30LAFatty-acid amide hydrolase 13.5.1.990.445
4emtC2EStimulator of interferon genes protein/0.445
4g7gVFVLanosterol 14-alpha-demethylase/0.445
4u8iFDAUDP-galactopyranose mutase/0.445
4uyf73BBromodomain-containing protein 2/0.445
4xxvNAD3-isopropylmalate dehydrogenase/0.445
5cwa0GAAnthranilate synthase component 14.1.3.270.445
5dp2NAPCurF/0.445
1k27MTMS-methyl-5'-thioadenosine phosphorylase/0.444
1n77ATPGlutamate--tRNA ligase6.1.1.170.444
1nhhANPDNA mismatch repair protein MutL/0.444
1ni1HFPProtein farnesyltransferase subunit beta2.5.1.580.444
1svmATPLarge T antigen3.6.40.444
1uopGLY_PHE_GLU_PROProlyl endopeptidase3.4.21.260.444
1vgrCOAFormyl-CoA:oxalate CoA-transferase/0.444
1w6hTITPlasmepsin-23.4.23.390.444
2cjfRP43-dehydroquinate dehydratase4.2.1.100.444
2ed5SAHDiphthine synthase/0.444
2ej2PPEBranched-chain amino acid aminotransferase (IlvE)/0.444
2futH1SHeparin and heparin-sulfate lyase/0.444
2i7nACOPantothenate kinase 12.7.1.330.444
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.444
2xdaJPS3-dehydroquinate dehydratase4.2.1.100.444
2xx91NFGlutamate receptor 2/0.444
2zruFMNIsopentenyl-diphosphate delta-isomerase/0.444
3axkNDPRibulose bisphosphate carboxylase large chain4.1.1.390.444
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.444
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.444
3gwdNAPCyclohexanone monooxygenase/0.444
3jpuTY4Transcriptional activator protein LasR/0.444
3pe2E1BCasein kinase II subunit alpha2.7.11.10.444
3tdj3TJGlutamate receptor 2/0.444
3tneRITCandidapepsin-13.4.23.240.444
3ukoNADAlcohol dehydrogenase class-3/0.444
3zbrNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.444
3zvmADPBifunctional polynucleotide phosphatase/kinase2.7.1.780.444
4dbzNDPPutative ketoacyl reductase1.3.10.444
1dmyAZMCarbonic anhydrase 5A, mitochondrial4.2.1.10.443
1f0xFADD-lactate dehydrogenase1.1.1.280.443
1h73ANPHomoserine kinase2.7.1.390.443
1j9zFADNADPH--cytochrome P450 reductase/0.443
1mj9COAHistone acetyltransferase ESA1/0.443
1x1aSAMC-20 methyltransferase/0.443
2e9cB75Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.443
2pncCLUPrimary amine oxidase, liver isozyme/0.443
2q1uNADPutative nucleotide sugar epimerase/ dehydratase/0.443
2v58LZJBiotin carboxylase6.3.4.140.443
3bnkFMNFlavoredoxin/0.443
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.443
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.443
3k1wBFXRenin3.4.23.150.443
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.443
3to3ATPPetrobactin biosynthesis protein AsbB/0.443
4b4w9L9Bifunctional protein FolD/0.443
4f32N323-oxoacyl-[acyl-carrier-protein] synthase 2/0.443
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.443
4i0h1BLBeta-secretase 13.4.23.460.443
4nbwNADShort-chain dehydrogenase/reductase SDR/0.443
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
5d3qGDPDynamin-13.6.5.50.443
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.443
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.443
5kjcPFBAlcohol dehydrogenase E chain1.1.1.10.443
1gcoNADGlucose 1-dehydrogenase1.1.1.470.442
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.442
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.442
1qo8FADFumarate reductase flavoprotein subunit/0.442
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2fg5GNPRas-related protein Rab-31/0.442
2fjeFADAdenylylsulfate reductase, subunit A (AprA)/0.442
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.442
2xvfFADPutative flavin-containing monooxygenase/0.442
2xvhFADPutative flavin-containing monooxygenase/0.442
2y0mACOHistone acetyltransferase KAT8/0.442
2zff53UProthrombin3.4.21.50.442
3aw9NADNAD-dependent epimerase/dehydratase/0.442
3dr8ACOL-methionine sulfoximine/L-methionine sulfone acetyltransferase/0.442
3kmc403Disintegrin and metalloproteinase domain-containing protein 173.4.24.860.442
3sj7NDP3-oxoacyl-(Acyl-carrier-protein) reductase, putative/0.442
3ufl508Beta-secretase 13.4.23.460.442
4frkDWDBeta-secretase 13.4.23.460.442
4l9kEHFSerum albumin/0.442
4qxr1YEStimulator of interferon genes protein/0.442
4xfjANPArgininosuccinate synthase/0.442
1d3dBZTProthrombin3.4.21.50.441
1jubFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.10.441
1me6IVSPlasmepsin-23.4.23.390.441
1q84TZ4Acetylcholinesterase3.1.1.70.441
1umkFADNADH-cytochrome b5 reductase 31.6.2.20.441
1ykfNAPNADP-dependent isopropanol dehydrogenase1.1.1.800.441
2b3dFADModulator of drug activity B/0.441
2ffqGSPRas-related protein Rab-6B/0.441
2fj1CTCTetracycline repressor protein class D/0.441
2h3wHC5Carnitine O-acetyltransferase2.3.1.70.441
2igoFADPyranose 2-oxidase/0.441
2iko7IGRenin3.4.23.150.441
2il2LIXRenin3.4.23.150.441
2v3oI26Prothrombin3.4.21.50.441
2vjmCOAFormyl-CoA:oxalate CoA-transferase/0.441
3e8xNAPBH1520 protein/0.441
3hdyFADUDP-galactopyranose mutase/0.441
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.441
3pm9FADPutative oxidoreductase/0.441
3q7fED2Uncharacterized protein/0.441
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.441
3v0o4GWHisto-blood group ABO system transferase/0.441
3v3m0ENReplicase polyprotein 1a3.4.19.120.441
4b68NAPL-ornithine N(5)-monooxygenase/0.441
4b79NADProbable short-chain dehydrogenase/0.441
4z24FADPutative GMC-type oxidoreductase R13510.441
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.441
1fwkADPHomoserine kinase2.7.1.390.440
1g0rTHMGlucose-1-phosphate thymidylyltransferase/0.440
1i3nUD1UDP-glucose 4-epimerase/0.440
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1pr9NAPL-xylulose reductase1.1.1.100.440
1zxcIH6Disintegrin and metalloproteinase domain-containing protein 173.4.24.860.440
2igyA2TPlasmepsin 2/0.440
2iwhANPElongation factor 3A/0.440
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.440
2rl1UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.440
2vq7NAPPutative flavin-containing monooxygenase/0.440
2xpuTDCTetracycline repressor protein class D/0.440
2yd0BESEndoplasmic reticulum aminopeptidase 13.4.110.440
2zr9DTPProtein RecA/0.440
3d3wNAPL-xylulose reductase1.1.1.100.440
3dhaC6LN-acyl homoserine lactonase AiiA3.1.1.810.440
3k5c0BIBeta-secretase 13.4.23.460.440
3kozZ97D-ornithine 4,5-aminomutase subunit beta/0.440
3kybFADUDP-galactopyranose mutase5.4.99.90.440
3rtnRTNBeta-secretase 13.4.23.460.440
3u5sFADFAD-linked sulfhydryl oxidase ALR1.8.3.20.440
3vvpBNUUncharacterized protein/0.440
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.440
4d9eLCSD-cysteine desulfhydrase/0.440
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.440
4fn4NADShort chain dehydrogenase/0.440
4fv7E94Mitogen-activated protein kinase 12.7.11.240.440
4iarERM5-hydroxytryptamine receptor 1B/0.440
4knjE1FCarbonic anhydrase 24.2.1.10.440
4tm0FADKtzI/0.440
4xsvCTPEthanolamine-phosphate cytidylyltransferase2.7.7.140.440
4yao2AMNADPH--cytochrome P450 reductase/0.440