sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3f47 | I2C | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3f47 | I2C | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 1.000 | |
| 3f46 | I2C | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 0.815 | |
| 3daf | FEG | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 0.709 | |
| 3dag | FEG | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 0.688 | |
| 3h65 | I2C | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 0.684 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.542 | |
| 4gkv | NAD | Alcohol dehydrogenase, propanol-preferring | 1.1.1.1 | 0.519 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.507 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.505 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.499 | |
| 3hdy | FAD | UDP-galactopyranose mutase | / | 0.497 | |
| 3tz3 | B36 | Acetyl-CoA carboxylase | / | 0.497 | |
| 2voj | NAD | Alanine dehydrogenase | 1.4.1.1 | 0.494 | |
| 3tea | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.494 | |
| 4lcg | 1WM | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.494 | |
| 4wji | NAP | Putative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase | / | 0.493 | |
| 5e8j | SAH | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.492 | |
| 3uhm | RFN | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.488 | |
| 3unk | 0BY | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.488 | |
| 4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.487 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.487 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.486 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.486 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.486 | |
| 4bid | IE8 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.486 | |
| 2ylr | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.485 | |
| 3iqe | F42 | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.485 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.484 | |
| 4l8u | 9AZ | Serum albumin | / | 0.484 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA2 | 3.6.3 | 0.483 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA1 | / | 0.483 | |
| 1civ | NAP | Malate dehydrogenase [NADP], chloroplastic | 1.1.1.82 | 0.481 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.481 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.481 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.481 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.481 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.481 | |
| 5jyd | NAD | Short chain dehydrogenase | / | 0.481 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.480 | |
| 1hdz | NAD | Alcohol dehydrogenase 1B | 1.1.1.1 | 0.480 | |
| 3ma3 | 01I | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.480 | |
| 1c70 | L75 | Protease | / | 0.479 | |
| 1ppj | ANY | Cytochrome b | / | 0.479 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.479 | |
| 1v0j | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.478 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.478 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.478 | |
| 1u28 | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.477 | |
| 2vna | NAP | Prostaglandin reductase 2 | 1.3.1.48 | 0.477 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.477 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.477 | |
| 2eph | ASP_TRP_ASN | Fructose-bisphosphate aldolase | 4.1.2.13 | 0.476 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.476 | |
| 3ezv | EZV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.476 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.476 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.475 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.475 | |
| 5br7 | FAD | UDP-galactopyranose mutase | / | 0.475 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.475 | |
| 1o8c | NDP | Probable acrylyl-CoA reductase AcuI | 1.3.1.84 | 0.474 | |
| 3jsk | AHZ | Thiamine thiazole synthase | / | 0.474 | |
| 3v9v | 21L | Peroxisome proliferator-activated receptor gamma | / | 0.474 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.473 | |
| 2iw9 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.473 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.473 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.473 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.473 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.473 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.472 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.472 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.472 | |
| 2vhw | NAI | Alanine dehydrogenase | 1.4.1.1 | 0.472 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.472 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.472 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.472 | |
| 1lld | NAD | L-lactate dehydrogenase 2 | 1.1.1.27 | 0.471 | |
| 2bpw | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.471 | |
| 4dwv | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.471 | |
| 2iw8 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.470 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.470 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.470 | |
| 1fbm | RTL | Cartilage oligomeric matrix protein | / | 0.469 | |
| 1nff | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.469 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.469 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.469 | |
| 2vhx | NAD | Alanine dehydrogenase | 1.4.1.1 | 0.469 | |
| 3kyb | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.469 | |
| 3sgt | P09 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | / | 0.469 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.469 | |
| 5eox | ADP | Type 4 fimbrial biogenesis protein PilM | / | 0.469 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.468 | |
| 4qgi | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.468 | |
| 1wvg | APR | CDP-glucose 4,6-dehydratase | 4.2.1.45 | 0.467 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.467 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.467 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.467 | |
| 4l9k | EHF | Serum albumin | / | 0.467 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.466 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.466 | |
| 2h3w | COA | Carnitine O-acetyltransferase | 2.3.1.7 | 0.466 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.466 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.466 | |
| 3ggp | NAD | Prephenate dehydrogenase | / | 0.466 | |
| 3hv5 | R24 | Mitogen-activated protein kinase 14 | / | 0.466 | |
| 4eny | J19 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.466 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.466 | |
| 1iy8 | NAD | Levodione reductase | / | 0.465 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.465 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.465 | |
| 2oxi | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.465 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.465 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.465 | |
| 2yy7 | NAD | L-threonine dehydrogenase | / | 0.465 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.465 | |
| 3abi | NAD | Uncharacterized protein | / | 0.465 | |
| 4cpd | NAD | Alcohol dehydrogenase | / | 0.465 | |
| 4nbu | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.465 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.464 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.464 | |
| 1mgo | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.464 | |
| 1ptj | SND | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.464 | |
| 1rkx | NAD | CDP-D-glucose-4,6-dehydratase | / | 0.464 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.464 | |
| 2yim | MC4 | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.464 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.464 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.464 | |
| 3qtz | X42 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.464 | |
| 4hfm | NAP | 2-alkenal reductase (NADP(+)-dependent) | / | 0.464 | |
| 4l04 | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.464 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.463 | |
| 2p9c | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.463 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.463 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.463 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.463 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.463 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.463 | |
| 3qu0 | X40 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 3rj5 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.463 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.462 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.462 | |
| 2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.462 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.462 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.462 | |
| 3hja | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.462 | |
| 3rmf | 20Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.462 | |
| 3zc3 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.462 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.462 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.462 | |
| 4j3d | 1JS | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.462 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.462 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.461 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.461 | |
| 1wyg | FAD | Xanthine dehydrogenase/oxidase | / | 0.461 | |
| 2fxe | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.461 | |
| 2oo5 | TXD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.461 | |
| 2z1m | NDP | GDP-mannose 4,6-dehydratase | / | 0.461 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.461 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.461 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.461 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3rak | 03Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.461 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.461 | |
| 4yt5 | H4M | H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 | / | 0.461 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.461 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 1hld | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.460 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.460 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 1ppm | 0P1 | Penicillopepsin-1 | 3.4.23.20 | 0.460 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.460 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.460 | |
| 3r9o | Z71 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.460 | |
| 3ral | 04Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.460 | |
| 3rwp | ABQ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.460 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.460 | |
| 3unj | 0BX | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.460 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.460 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1rdw | LAR | Actin, alpha skeletal muscle | / | 0.459 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.459 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.459 | |
| 2uuv | FAD | Alkyldihydroxyacetonephosphate synthase | 2.5.1.26 | 0.459 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.459 | |
| 2ycf | YCF | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.459 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.459 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.459 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.459 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.459 | |
| 4eu5 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.459 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.459 | |
| 4ft0 | HK9 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 4hjf | C2E | GGDEF family protein | / | 0.459 | |
| 4xxv | NAD | 3-isopropylmalate dehydrogenase | / | 0.459 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.458 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1osv | CHC | Bile acid receptor | / | 0.458 | |
| 2a1u | FAD | Electron transfer flavoprotein subunit alpha, mitochondrial | / | 0.458 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.458 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.458 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.458 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.458 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.458 | |
| 3gcn | TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.458 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.458 | |
| 1i8t | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.457 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 1npa | 3NH | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 1npw | LGZ | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.457 | |
| 2d8a | NAD | L-threonine 3-dehydrogenase | / | 0.457 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.457 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.457 | |
| 2k62 | ITL | Fatty acid-binding protein, liver | / | 0.457 | |
| 2p2l | GDP | Ras-related C3 botulinum toxin substrate 1 | / | 0.457 | |
| 3aba | FLI | Cytochrome P450 | / | 0.457 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.457 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.457 | |
| 3sz0 | FAD | Sulfide-quinone reductase | / | 0.457 | |
| 4a6c | QG9 | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 4b7x | NAP | Probable oxidoreductase | / | 0.457 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 4ydu | ADP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.457 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.456 | |
| 3fcj | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.456 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.456 | |
| 3q8u | ADP | Nucleoside diphosphate kinase | / | 0.456 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.456 | |
| 4fzv | SAM | 5-methylcytosine rRNA methyltransferase NSUN4 | 2.1.1 | 0.456 | |
| 4jaz | STL | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.456 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.456 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.456 | |
| 1efv | FAD | Electron transfer flavoprotein subunit alpha, mitochondrial | / | 0.455 | |
| 1fm6 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 2ar8 | FAD | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.455 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.455 | |
| 2dkn | NAI | 3-alpha-hydroxysteroid dehydrogenase | / | 0.455 | |
| 2fgk | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.455 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.455 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.455 | |
| 2vhz | NAI | Alanine dehydrogenase | 1.4.1.1 | 0.455 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.455 | |
| 3etd | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.455 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.455 | |
| 3t14 | FAD | Sulfide-quinone reductase | / | 0.455 | |
| 3v9y | 24L | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.455 | |
| 4eub | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.455 | |
| 4qmp | DKI | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.455 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.455 | |
| 5emh | NAP | Iridoid synthase | 1.3.1.99 | 0.455 | |
| 5g3t | FDA | Flavin-dependent L-tryptophan oxidase VioA | / | 0.455 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.455 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.454 | |
| 1tdu | CB3 | Thymidylate synthase | / | 0.454 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.454 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.454 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.454 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.454 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.454 | |
| 3cin | NAD | Myo-inositol-1-phosphate synthase-related protein | / | 0.454 | |
| 3cxw | 7CP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.454 | |
| 3gco | VAL_TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.454 | |
| 3ggo | NAI | Prephenate dehydrogenase | / | 0.454 | |
| 3ox4 | NAD | Alcohol dehydrogenase 2 | 1.1.1.1 | 0.454 | |
| 3p3c | 3P3 | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.454 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.454 | |
| 3vsp | EK8 | Peroxisome proliferator-activated receptor gamma | / | 0.454 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.454 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.454 | |
| 4fv7 | E94 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.454 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.454 | |
| 4qi7 | FAD | Cellobiose dehydrogenase | / | 0.454 | |
| 4xx0 | COA | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial | 6.2.1.4 | 0.454 | |
| 4xyb | NDP | Formate dehydrogenase | / | 0.454 | |
| 5dcy | NAP | Iridoid synthase | 1.3.1.99 | 0.454 | |
| 1c6x | 3IN | Protease | / | 0.453 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.453 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.453 | |
| 1oiy | N41 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.453 | |
| 1t0l | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.453 | |
| 1tj1 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.453 | |
| 2fhj | MFN | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.453 | |
| 2hve | ADP | Nucleoside diphosphate kinase A | 2.7.4.6 | 0.453 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.453 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.453 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.453 | |
| 2xyn | VX6 | Abelson tyrosine-protein kinase 2 | 2.7.10.2 | 0.453 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 3fl9 | TOP | Dihydrofolate reductase | / | 0.453 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.453 | |
| 3oxv | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 3pt6 | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.453 | |
| 3tiz | 3TI | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 4e5n | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.453 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.453 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 4wlo | NAI | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.453 | |
| 4ykf | FAD | Alkyl hydroperoxide reductase subunit F | 1.8.1 | 0.453 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.453 | |
| 1hwz | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.452 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 1uum | AFI | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.452 | |
| 1wn3 | HXC | Phenylacetic acid degradation protein PaaI | / | 0.452 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.452 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.452 | |
| 2gew | FAD | Cholesterol oxidase | 1.1.3.6 | 0.452 | |
| 2gst | GPS | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.452 | |
| 2qfx | NDP | Isocitrate dehydrogenase [NADP], mitochondrial | 1.1.1.42 | 0.452 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.452 | |
| 3nbv | ANP | Ketohexokinase | / | 0.452 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3rpv | 26Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.452 | |
| 3w33 | W19 | Epidermal growth factor receptor | 2.7.10.1 | 0.452 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.452 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.452 | |
| 4jbi | NDP | Alcohol dehydrogenase (Zinc) | / | 0.452 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.452 | |
| 4lch | 1WN | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.452 | |
| 4njv | RIT | Protease | / | 0.452 | |
| 4qmn | DB8 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.452 | |
| 4xgi | NAD | Glutamate dehydrogenase | / | 0.452 | |
| 1ke8 | LS4 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 2bb9 | AKC | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.451 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.451 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.451 | |
| 3fri | SAH | 16S rRNA methylase | / | 0.451 | |
| 3n7u | NAD | Formate dehydrogenase, chloroplastic/mitochondrial | / | 0.451 | |
| 3ngu | ADP | Nucleoside diphosphate kinase | / | 0.451 | |
| 3r32 | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.451 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.451 | |
| 3vth | AP2 | Carbamoyltransferase | / | 0.451 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.451 | |
| 4ach | KDI | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.451 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.451 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.451 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.451 | |
| 4kqw | NAP | Ketol-acid reductoisomerase (NADP(+)) | / | 0.451 | |
| 4n6b | COA | Uncharacterized protein | / | 0.451 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.451 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.451 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.451 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.451 | |
| 1bxs | NAD | Retinal dehydrogenase 1 | 1.2.1.36 | 0.450 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.450 | |
| 1p31 | EPU | UDP-N-acetylmuramate--L-alanine ligase | 6.3.2.8 | 0.450 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.450 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.450 | |
| 2fsv | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.450 | |
| 2j3k | NAP | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.450 | |
| 2q3k | MUW | Gag-Pol polyprotein | / | 0.450 | |
| 2vhv | NAI | Alanine dehydrogenase | 1.4.1.1 | 0.450 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.450 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.450 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.450 | |
| 3fpj | SAM | Uncharacterized protein | / | 0.450 | |
| 3gbk | 2PQ | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 3hdy | FDA | UDP-galactopyranose mutase | / | 0.450 | |
| 3py0 | SU9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 3rpy | 27Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 4cdm | FAD | Deoxyribodipyrimidine photolyase | / | 0.450 | |
| 4enx | Z20 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 4h4w | NAP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.450 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.450 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.450 | |
| 5js6 | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.450 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.450 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.449 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.449 | |
| 1kqo | DND | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.449 | |
| 1urw | I1P | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 1ysx | 4EB | Serum albumin | / | 0.449 | |
| 2hfp | NSI | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.449 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2yyl | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.449 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.449 | |
| 3i59 | N6R | CRP-like cAMP-activated global transcriptional regulator | / | 0.449 | |
| 3zpt | M8Y | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 4bi1 | ZO6 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.449 | |
| 4iah | 1DX | Alr2278 protein | / | 0.449 | |
| 4rpg | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.449 | |
| 4x9n | FAD | Uncharacterized protein MG039 homolog | / | 0.449 | |
| 1esv | LAR | Actin, alpha skeletal muscle | / | 0.448 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 1pmn | 984 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.448 | |
| 1qvn | FRI | Interleukin-2 | / | 0.448 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.448 | |
| 1tlc | F89 | Thymidylate synthase | / | 0.448 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.448 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.448 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.448 | |
| 2onm | ADP | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.448 | |
| 2oor | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.448 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.448 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.448 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.448 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.448 | |
| 3r9d | X6B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 3sdk | P3N | Proteasome subunit beta type-5 | 3.4.25.1 | 0.448 | |
| 3sdk | P3N | Proteasome subunit beta type-6 | 3.4.25.1 | 0.448 | |
| 3stv | 3HO | Methylketone synthase I | / | 0.448 | |
| 3sw7 | 19K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.448 | |
| 3tvu | B37 | Acetyl-CoA carboxylase | / | 0.448 | |
| 3uwl | FOZ | Thymidylate synthase | / | 0.448 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.448 | |
| 4afj | SJJ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.448 | |
| 4cr8 | NAD | N-acylmannosamine 1-dehydrogenase | 1.1.1.233 | 0.448 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.448 | |
| 4iaw | LIZ | Neutrophil gelatinase-associated lipocalin | / | 0.448 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.448 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.448 | |
| 4opu | FDA | Conserved Archaeal protein | / | 0.448 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 4rqk | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.448 | |
| 4wsq | KSA | AP2-associated protein kinase 1 | 2.7.11.1 | 0.448 | |
| 1cbs | REA | Cellular retinoic acid-binding protein 2 | / | 0.447 | |
| 1pg3 | PRX | Acetyl-coenzyme A synthetase | / | 0.447 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.447 | |
| 2bi4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.447 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.447 | |
| 2ohx | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
| 2ylx | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.447 | |
| 3ete | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.447 | |
| 3he3 | FAD | UDP-galactopyranose mutase | / | 0.447 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.447 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.447 | |
| 3sh0 | SAX | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.447 | |
| 3t2y | FAD | Sulfide-quinone reductase | / | 0.447 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.447 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.447 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.447 | |
| 4fgg | 0U5 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.447 | |
| 4g17 | 0VN | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.447 | |
| 4l03 | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.447 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.447 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.447 | |
| 1bwf | ATF | Glycerol kinase | / | 0.446 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.446 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1lj8 | NAD | Mannitol dehydrogenase | / | 0.446 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.446 | |
| 1w7k | ADP | Dihydrofolate synthase/folylpolyglutamate synthase | 6.3.2.12 | 0.446 | |
| 1zgy | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.446 | |
| 2jt2 | C90 | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.446 | |
| 2p2b | PRX | Acetyl-coenzyme A synthetase | / | 0.446 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.446 | |
| 3pb3 | SAH | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.446 | |
| 3qxp | X64 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.446 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.446 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.446 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.446 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.446 | |
| 4kzo | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.446 | |
| 4ng5 | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 4ytn | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.446 | |
| 5doz | NDP | JamJ | / | 0.446 | |
| 1adc | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.445 | |
| 1b15 | NAE | Alcohol dehydrogenase | 1.1.1.1 | 0.445 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.445 | |
| 1gij | 2PU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 1ke9 | LS5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 1knr | FAD | L-aspartate oxidase | 1.4.3.16 | 0.445 | |
| 1n1p | FAD | Cholesterol oxidase | 1.1.3.6 | 0.445 | |
| 1wuu | ANP | Galactokinase | 2.7.1.6 | 0.445 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.445 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.445 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 2e9c | B75 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.445 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2xk9 | XK9 | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.445 | |
| 3gst | GPR | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.445 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.445 | |
| 3ncg | BK1 | Calmodulin-domain protein kinase 1, putative | / | 0.445 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.445 | |
| 4a33 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 4n9w | GDP | Phosphatidyl-myo-inositol mannosyltransferase | 2.4.1.57 | 0.445 | |
| 4o2z | 046 | Mitogen-activated protein kinase | / | 0.445 | |
| 4rpj | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.445 | |
| 5ag7 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 1bvg | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 1c6z | ROC | Protease | / | 0.444 | |
| 1oi9 | N20 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.444 | |
| 2j3i | NAP | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.444 | |
| 2ozu | ACO | Histone acetyltransferase KAT6A | / | 0.444 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.444 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.444 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.444 | |
| 2zno | S44 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 3be9 | P04 | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
| 3bqd | DAY | Glucocorticoid receptor | / | 0.444 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.444 | |
| 3l8p | 0CE | Angiopoietin-1 receptor | 2.7.10.1 | 0.444 | |
| 3r3f | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.444 | |
| 3ruq | ADP | Chaperonin | / | 0.444 | |
| 3ttj | JBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.444 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.444 | |
| 4acg | 6LQ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.444 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.444 | |
| 4c2y | MYA | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.444 | |
| 4da6 | GA2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.444 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.444 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.444 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1ha3 | MAU | Elongation factor Tu-A | / | 0.443 | |
| 1iqr | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.443 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.443 | |
| 1ke5 | LS1 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 1ke6 | LS2 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 1qrr | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.443 | |
| 1rbm | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.443 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.443 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.443 | |
| 1yt9 | OIS | Gag-Pol polyprotein | / | 0.443 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.443 | |
| 2qnq | QN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2zwv | SAH | Probable ribosomal RNA small subunit methyltransferase | / | 0.443 | |
| 3aid | ARQ | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 3oev | 3OE | Proteasome subunit beta type-5 | 3.4.25.1 | 0.443 | |
| 3oev | 3OE | Proteasome subunit beta type-6 | 3.4.25.1 | 0.443 | |
| 3w2e | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.443 | |
| 3wxy | COA | Uncharacterized protein | / | 0.443 | |
| 4fko | 20K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 4o8a | FAD | Bifunctional protein PutA | 1.2.1.88 | 0.443 | |
| 4pd6 | URI | Nucleoside permease | / | 0.443 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.443 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.443 | |
| 4wlv | NAD | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.443 | |
| 4xye | NAD | Formate dehydrogenase | / | 0.443 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.443 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 5dn3 | ATP | Aurora kinase A | 2.7.11.1 | 0.443 | |
| 1bv7 | XV6 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1cc2 | FAD | Cholesterol oxidase | 1.1.3.6 | 0.442 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1hii | C20 | Gag-Pol polyprotein | / | 0.442 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1obb | NAD | Alpha-glucosidase | 3.2.1.20 | 0.442 | |
| 2b9y | FAD | Putative aminooxidase | / | 0.442 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.442 | |
| 2cmv | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.442 | |
| 2cvj | FAD | Thioredoxin reductase related protein | / | 0.442 | |
| 2d4v | NAD | Isocitrate dehydrogenase [NADP] | / | 0.442 | |
| 2ehu | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.442 | |
| 2exc | JNK | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.442 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.442 | |
| 2w05 | FRT | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.442 | |
| 2y3r | TIR | TamL | / | 0.442 | |
| 3a7r | LAQ | Lipoate-protein ligase A | 6.3.1.20 | 0.442 | |
| 3ama | SKE | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3fpz | AHZ | Thiamine thiazole synthase | / | 0.442 | |
| 3ijo | B4D | Glutamate receptor 2 | / | 0.442 | |
| 3oag | LPQ | Renin | 3.4.23.15 | 0.442 | |
| 3stw | 2TD | Methylketone synthase I | / | 0.442 | |
| 3stx | BKA | Methylketone synthase I | / | 0.442 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.442 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 4cjw | CBJ | Integrase | / | 0.442 | |
| 4do3 | 0LA | Fatty-acid amide hydrolase 1 | 3.5.1.99 | 0.442 | |
| 4fkr | 45K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 4gt3 | ATP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.442 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.442 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.442 | |
| 4kfb | 1QP | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 4lmn | EUI | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.442 | |
| 4nu6 | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.442 | |
| 4qbj | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.442 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.442 | |
| 4trj | 665 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.442 | |
| 5a3b | APR | SIR2 family protein | / | 0.442 | |
| 5br4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.442 | |
| 1ahi | CHO | 7-alpha-hydroxysteroid dehydrogenase | 1.1.1.159 | 0.441 | |
| 1iid | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.441 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.441 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.441 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.441 | |
| 1vcf | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.441 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.441 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.441 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2bac | FAD | Putative aminooxidase | / | 0.441 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.441 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.441 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.441 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.441 | |
| 2oye | IM8 | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.441 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.441 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.441 | |
| 2ydi | YDI | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.441 | |
| 3amb | VX6 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.441 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.441 | |
| 3ime | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.441 | |
| 3kq7 | KQ7 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.441 | |
| 3slz | 3TL | Putative gag-pro-pol polyprotein | / | 0.441 | |
| 4ftr | 5HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 4h4u | NDP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.441 | |
| 4lis | NAD | UDP-glucose 4-epimerase (Eurofung) | / | 0.441 | |
| 4yry | FAD | Glutamate synthase, beta subunit | / | 0.441 | |
| 8dfr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.440 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.440 | |
| 1gii | 1PU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1hzz | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.440 | |
| 1npv | L27 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1om1 | IQA | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.440 | |
| 1wc1 | TAT | Adenylate cyclase | / | 0.440 | |
| 2fvd | LIA | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.440 | |
| 2hqp | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.440 | |
| 2wet | FAD | Tryptophan 5-halogenase | / | 0.440 | |
| 2wxv | WXV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.440 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.440 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.440 | |
| 3lit | E15 | Protease | / | 0.440 | |
| 3p4t | FAO | Putative acyl-CoA dehydrogenase | / | 0.440 | |
| 3poz | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.440 | |
| 3sgx | 0FW | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.440 | |
| 3zsi | 52P | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.440 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.440 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 4da8 | BG2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.440 | |
| 4en4 | ATP | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.440 | |
| 4fc0 | 0T2 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.440 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.440 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.440 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4l06 | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.440 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.440 | |
| 4wbo | ANW | Rhodopsin kinase | / | 0.440 | |
| 4ynt | FDA | Glucose oxidase, putative | / | 0.440 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.440 |