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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4eesFMNPhototropin-22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4eesFMNPhototropin-22.7.11.11.000
2z6cFMNPhototropin-12.7.11.10.637
4eetFMNPhototropin-22.7.11.10.606
5efwFMNNPH1-1/0.593
2pd8FADVivid PAS protein VVD/0.589
1n9nFMNPutative blue light receptor/0.587
2v1aFMNNPH1-1/0.585
4eerFMNPhototropin-22.7.11.10.574
2z6dFMNPhototropin-22.7.11.10.573
4hj6FMNLOV protein/0.570
4kukRBFPutative blue-light photoreceptor/0.566
4eepFMNPhototropin-22.7.11.10.564
4hiaFMNLOV protein/0.562
5djtFMNNPH1-2/0.562
2v0uFMNNPH1-1/0.555
2pd7FADVivid PAS protein VVD/0.553
1g28FMNPHY3/0.544
4kuoRBFPutative blue-light photoreceptor/0.544
1n9lFMNPutative blue light receptor/0.542
3t50FMNBlue-light-activated histidine kinase2.7.13.30.536
4eeuFMNPhototropin-22.7.11.10.531
4hj4FMNLOV protein/0.531
2pr5FMNBlue-light photoreceptor/0.528
4hhdFMNPhototropin-12.7.11.10.526
4r38RBFBlue-light-activated histidine kinase 22.7.13.30.525
4hj3FMNLOV protein/0.522
3sw1FMNSensory box protein/0.521
3p7nFMNLight-activated DNA-binding protein EL222/0.520
2pdtFADVivid PAS protein VVD/0.519
3is2FADVivid PAS protein VVD/0.519
5djuFMNNPH1-2/0.518
3hjiFADVivid PAS protein VVD/0.513
3d72FADVivid PAS protein VVD/0.508
4hnbFMNLOV protein/0.506
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.504
3hjkFADVivid PAS protein VVD/0.503
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.503
4ji91M3Tyrosine-protein kinase JAK2/0.503
1xddAAYIntegrin alpha-L/0.500
2jlcTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.500
5dkkFMNPredicted protein/0.500
2briANPUridylate kinase2.7.4.220.498
3ibqATPPyridoxal kinase/0.498
4du82P0Mevalonate diphosphate decarboxylase/0.497
1ib0NADNADH-cytochrome b5 reductase 31.6.2.20.496
4k28NADShikimate dehydrogenase family protein/0.495
3u9eCOALmo1369 protein/0.491
5i4nATPTyrosine-protein kinase JAK2/0.491
3au8NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic1.1.1.2670.489
4dpuAGSMevalonate diphosphate decarboxylase/0.489
5j3wFMNSensory box protein/0.489
5j4eFMNSensory box protein/0.489
4wucANPDNA gyrase subunit B/0.488
2ejvNADL-threonine 3-dehydrogenase/0.487
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.486
2hckQUETyrosine-protein kinase HCK2.7.10.20.486
2bu2ATP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.485
3ue6FMNAureochrome1/0.485
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.485
4cukNAID-lactate dehydrogenase/0.484
2zkjADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.483
2ahcVNLChorismate pyruvate-lyase/0.482
2qblCAMCamphor 5-monooxygenase1.14.15.10.482
4wudANPDNA gyrase subunit B/0.482
1qo8FADFumarate reductase flavoprotein subunit/0.481
1vfrFMNMajor NAD(P)H-flavin oxidoreductase1.6.990.481
3dv3MEKDual specificity mitogen-activated protein kinase kinase 12.7.12.20.481
3lqfNADGalactitol dehydrogenase/0.481
4dpy2P0Mevalonate diphosphate decarboxylase/0.481
3qsaTA7Anthranilate phosphoribosyltransferase/0.479
1nhhANPDNA mismatch repair protein MutL/0.478
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.478
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.478
1i59ANPChemotaxis protein CheA2.7.13.30.477
3biy01KHistone acetyltransferase p300/0.477
3pe2E1BCasein kinase II subunit alpha2.7.11.10.477
3s1dZIRCytokinin dehydrogenase 11.5.99.120.477
4rpgFADUDP-galactopyranose mutase5.4.99.90.477
3hyoADPPyridoxal kinase/0.476
4dbzNDPPutative ketoacyl reductase1.3.10.476
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.475
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.475
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.475
3fwiCAMCamphor 5-monooxygenase1.14.15.10.475
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.474
3zv64HBCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase1.3.1.560.474
4prxADPDNA gyrase subunit B/0.474
3giyFMN(S)-mandelate dehydrogenase1.1.99.310.473
3juqAJDPhenazine biosynthesis protein A/B/0.473
3w6hAZMCarbonic anhydrase 14.2.1.10.473
4m11MXMProstaglandin G/H synthase 21.14.99.10.473
1dg8NDPDihydrofolate reductase1.5.1.30.472
2b56UTPRNA editing complex protein MP57/0.472
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.472
2j2pSC2Ficolin-2/0.472
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
3nbvANPKetohexokinase/0.472
4lj9ACPChaperone protein ClpB/0.472
2e0aANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.471
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.471
3b9lAZZSerum albumin/0.471
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.471
1q12ATPMaltose/maltodextrin import ATP-binding protein MalK/0.470
3pj8404Cyclin-dependent kinase 22.7.11.220.470
1g1aNADdTDP-glucose 4,6-dehydratase/0.469
1nooCAHCamphor 5-monooxygenase1.14.15.10.469
2y3rTRKTamL/0.469
3oibFDAPutative acyl-CoA dehydrogenase/0.469
1nzfUPGDNA beta-glucosyltransferase/0.468
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.468
2cig1DGDihydrofolate reductase1.5.1.30.468
2ydxSTLMethionine adenosyltransferase 2 subunit beta/0.468
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.467
2j08IRFDeoxyribodipyrimidine photo-lyase4.1.99.30.467
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.467
3a14NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.467
3kbz2T4Fructose-1,6-bisphosphatase 13.1.3.110.467
5e8ySTUTGF-beta receptor type-22.7.11.300.467
1f0yCAAHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.466
1j7kATPHolliday junction ATP-dependent DNA helicase RuvB/0.466
1oonFMNOxygen-insensitive NAD(P)H nitroreductase/0.466
3c1y2BADNA integrity scanning protein DisA/0.466
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.466
3kjm245Cytokinin dehydrogenase 11.5.99.120.466
4dgnLU2Casein kinase II subunit alpha2.7.11.10.466
4h4yNAPBiphenyl dioxygenase ferredoxin reductase subunit/0.466
2b69NADUDP-glucuronic acid decarboxylase 14.1.1.350.465
3a0tADPSensor histidine kinase/0.465
3hwxTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.465
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.465
1glfADPGlycerol kinase/0.464
2e0nSAHPrecorrin-2 C20-methyltransferase/0.464
2vqdAP2Biotin carboxylase6.3.4.140.464
3uqdADPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.464
4fhd0TTSpore photoproduct lyase/0.464
1kp2ATPArgininosuccinate synthase6.3.4.50.463
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.463
3fwfCAMCamphor 5-monooxygenase1.14.15.10.463
3kvxFMYMitogen-activated protein kinase 102.7.11.240.463
3mjeNDPAmphB/0.463
3r6c17NAnthranilate phosphoribosyltransferase/0.463
4i8vBHFCytochrome P450 1A11.14.14.10.463
2v1xADPATP-dependent DNA helicase Q13.6.4.120.462
3b1jNADGlyceraldehyde-3-phosphate dehydrogenase/0.462
3gbuATPUncharacterized sugar kinase PH14592.7.10.462
3gfbNADL-threonine 3-dehydrogenase/0.462
1ib6NADMalate dehydrogenase/0.461
1msmJE2Gag-Pol polyprotein3.4.23.160.461
1njfAGSDNA polymerase III subunit tau2.7.7.70.461
1r6tTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.461
2ahrNAPPyrroline-5-carboxylate reductase/0.461
2bb9AKCGag-Pol polyprotein3.4.23.160.461
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.461
2q29ACOOxalyl-CoA decarboxylase4.1.1.80.461
3fwgCAMCamphor 5-monooxygenase1.14.15.10.461
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.461
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.461
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.461
3w9rA8SAbscisic acid receptor PYL9/0.461
3wrjCAMCamphor 5-monooxygenase1.14.15.10.461
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
4o1pANPRibonuclease L/0.461
1drhNAPDihydrofolate reductase1.5.1.30.460
1gilGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.460
1yzqGNPRas-related protein Rab-6A/0.460
2freFMNNAD(P)H-flavin oxidoreductase/0.460
2gesCOKPantothenate kinase2.7.1.330.460
3junAKDPhenazine biosynthesis protein A/B/0.460
3otfCMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4/0.460
3qt62P0Mevalonate diphosphate decarboxylase/0.460
3slkNDPPolyketide synthase extender module 2/0.460
3zkyWT4Isopenicillin N synthase1.21.3.10.460
4hwkNAPSepiapterin reductase1.1.1.1530.460
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.460
4r1lADPPhenylacetate-coenzyme A ligase/0.460
1in5ADPHolliday junction ATP-dependent DNA helicase RuvB/0.459
1ofeFMNFerredoxin-dependent glutamate synthase 21.4.7.10.459
1udaUFGUDP-glucose 4-epimerase5.1.3.20.459
2a1mCAMCamphor 5-monooxygenase1.14.15.10.459
2aa3AP0L-lactate dehydrogenase/0.459
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.459
2zxuDSTtRNA dimethylallyltransferase2.5.1.750.459
3d8vUD1Bifunctional protein GlmU/0.459
3n7uNADFormate dehydrogenase, chloroplastic/mitochondrial/0.459
3nt6COAFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.459
3pxvFMNNitroreductase/0.459
3t3c017Gag-Pol polyprotein3.4.23.160.459
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.459
4fv6E57Mitogen-activated protein kinase 12.7.11.240.459
4jqlVJ6Heat shock protein HSP 90-alpha/0.459
4k33ACPFibroblast growth factor receptor 32.7.10.10.459
4l0qNADAlcohol dehydrogenase class-3/0.459
4pzrCOAHistone acetyltransferase p300/0.459
6cp4CAMCamphor 5-monooxygenase1.14.15.10.459
1rfuADPPyridoxal kinase2.7.1.350.458
1t86CAMCamphor 5-monooxygenase1.14.15.10.458
1zw1TN5Enoyl-ACP reductase/0.458
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.458
2d8aNADL-threonine 3-dehydrogenase/0.458
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.458
2ylsFADPhenylacetone monooxygenase1.14.13.920.458
3cs8BRLPeroxisome proliferator-activated receptor gamma/0.458
3h06VBPGlutamate receptor 2/0.458
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.458
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
4ehzJAKTyrosine-protein kinase JAK1/0.458
4f9c0SXCell division cycle 7-related protein kinase2.7.11.10.458
4g3rCAMCamphor 5-monooxygenase1.14.15.10.458
4in44IDKelch-like ECH-associated protein 1/0.458
4xyeNADFormate dehydrogenase/0.458
5c88COAN-alpha-acetyltransferase/0.458
1ipeNDPTropinone reductase 21.1.1.2360.457
1kbjFMNCytochrome b2, mitochondrial1.1.2.30.457
1o76CAMCamphor 5-monooxygenase1.14.15.10.457
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.457
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.457
2pckSAHDiphthine synthase/0.457
2qboCAMCamphor 5-monooxygenase1.14.15.10.457
2znq401Peroxisome proliferator-activated receptor delta/0.457
3c212BADNA integrity scanning protein DisA/0.457
3d2rADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.457
3d4pNADL-lactate dehydrogenase 11.1.1.270.457
3dagFEG5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.457
3glmCOOGlutaconyl-CoA decarboxylase alpha subunit/0.457
3k145352-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase/0.457
3nl6TPSUncharacterized protein/0.457
3t4nADP5'-AMP-activated protein kinase subunit gamma/0.457
3vhxGTPADP-ribosylation factor 6/0.457
3zkbANPDNA gyrase subunit B/0.457
4f650S9Fibroblast growth factor receptor 1/0.457
4m4922YL-lactate dehydrogenase A chain1.1.1.270.457
4wujFMNGlycoside hydrolase family 15, cellulose signaling associated protein envoy/0.457
1a8rGTPGTP cyclohydrolase 13.5.4.160.456
1rx8NAPDihydrofolate reductase1.5.1.30.456
1u3dFADCryptochrome-1/0.456
3sfeFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.456
3t2sAGSHeat shock protein HSP 90-alpha/0.456
3w6uNAP6-phosphogluconate dehydrogenase, NAD-binding protein/0.456
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
4ienCOAPutative acyl-CoA hydrolase/0.456
5ej9TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.456
1bwb146Gag-Pol polyprotein3.4.23.160.455
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.455
1i8tFADUDP-galactopyranose mutase5.4.99.90.455
1t88CAMCamphor 5-monooxygenase1.14.15.10.455
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.455
1z4uPH9Polyprotein/0.455
2ejzSAHDiphthine synthase/0.455
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.455
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.455
2p9gNAID-3-phosphoglycerate dehydrogenase1.1.1.950.455
2rabFADGlutathione amide reductase/0.455
2vwqNAPGlucose 1-dehydrogenase/0.455
3idsNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.455
4a6nFADTetX family tetracycline inactivation enzyme/0.455
4bhw01KHistone acetyltransferase p300/0.455
4h4qFADBiphenyl dioxygenase ferredoxin reductase subunit/0.455
4rosAPRMalate dehydrogenase/0.455
5ejaTD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.455
1dr2TAPDihydrofolate reductase1.5.1.30.454
1tj2FADBifunctional protein PutA1.5.5.20.454
1u3cFADCryptochrome-1/0.454
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.454
2eh2SAHDiphthine synthase/0.454
2nv4SAMS-adenosyl-L-methionine-binding protein AF_0241/0.454
2qenADPWalker-Type ATPase/0.454
2xs0ANPMitogen-activated protein kinase 82.7.11.240.454
2zdt46CMitogen-activated protein kinase 102.7.11.240.454
3oquA8SAbscisic acid receptor PYL9/0.454
3umvFADDeoxyribodipyrimidine photo-lyase4.1.99.30.454
4eqrFADCoenzyme A disulfide reductase/0.454
4ipeANPTNF receptor-associated protein 1/0.454
4ww4ADPRuvB-like helicase/0.454
1sguMK1Gag-Pol polyprotein3.4.23.160.453
1ykiFMNOxygen-insensitive NAD(P)H nitroreductase/0.453
2cy0NAPShikimate dehydrogenase (NADP(+))/0.453
2g1r3IGRenin3.4.23.150.453
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.453
2xrwANPMitogen-activated protein kinase 82.7.11.240.453
2xyuQ9GEphrin type-A receptor 42.7.10.10.453
2y4gTIRTamL/0.453
3lpbNVBTyrosine-protein kinase JAK2/0.453
3pcrGTPADP-ribosylation factor 6/0.453
3tr05GPGuanylate kinase/0.453
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.453
4fvqATPTyrosine-protein kinase JAK2/0.453
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
4gt8ADPSensor protein VraS2.7.13.30.453
4m10ICDProstaglandin G/H synthase 21.14.99.10.453
4tuvCPZCytochrome P450 1191.140.453
5bsgNAPPyrroline-5-carboxylate reductase/0.453
1culGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.452
1d7lRFLp-hydroxybenzoate hydroxylase/0.452
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.452
1gveNAPAflatoxin B1 aldehyde reductase member 310.452
1nzdUPGDNA beta-glucosyltransferase/0.452
1rrmAPRLactaldehyde reductase1.1.1.770.452
1rx1NAPDihydrofolate reductase1.5.1.30.452
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.452
2c27ACOMycothiol acetyltransferase2.3.1.1890.452
2d1cNAPIsocitrate dehydrogenase [NADP]1.1.1.420.452
2dwbANPAurora kinase A2.7.11.10.452
2e16SAHDiphthine synthase/0.452
2j07HDFDeoxyribodipyrimidine photo-lyase4.1.99.30.452
2mwgFMNBlue-light photoreceptor/0.452
2yg4FADPutrescine oxidase/0.452
3clyACPFibroblast growth factor receptor 2/0.452
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
3mpt1GKMitogen-activated protein kinase 14/0.452
3oafOAGDihydrofolate reductase1.5.1.30.452
3uyt0CKCasein kinase I isoform delta2.7.11.10.452
3zdfNADGlyceraldehyde-3-phosphate dehydrogenase/0.452
4fduIHSPutative multiple inositol polyphosphate histidine phosphatase 1/0.452
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.452
4i1iNADMalate dehydrogenase/0.452
4jldADPAdenylate kinase/0.452
4l06NAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.452
4lrzADPPEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL2.70.452
4nd4NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.452
4o0sADNAurora kinase A2.7.11.10.452
5a3cNADSIR2 family protein/0.452
5cvcPLPSerine racemase/0.452
1bcpATPPertussis toxin subunit 4/0.451
1bcpATPPertussis toxin subunit 5/0.451
1bw9NADPhenylalanine dehydrogenase/0.451
1vzdCB3Thymidylate synthase/0.451
1x2hLPALipoate-protein ligase A6.3.1.200.451
2gjnFMNNitronate monooxygenase1.13.12.160.451
2oo7AP5Adenylate kinase/0.451
2q85973UDP-N-acetylenolpyruvoylglucosamine reductase1.3.1.980.451
2y0mACOHistone acetyltransferase KAT8/0.451
2yyuC5POrotidine 5'-phosphate decarboxylase/0.451
3eljGS7Mitogen-activated protein kinase 82.7.11.240.451
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.451
3mknDNBPyrimidine-specific ribonucleoside hydrolase RihB/0.451
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.451
4eu8COASuccinyl-CoA:acetate CoA-transferase/0.451
4lb2DM5Serum albumin/0.451
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.451
4xj43ATCyclic GMP-AMP synthase/0.451
5dr2ATPAurora kinase A2.7.11.10.451
1bmdNADMalate dehydrogenase/0.450
1uyhPU0Heat shock protein HSP 90-alpha/0.450
2e07SAHDiphthine synthase/0.450
2owkSAHDiphthine synthase/0.450
2pmoHMDProtein kinase 7/0.450
2pvnP63Casein kinase II subunit alpha2.7.11.10.450
2ywvADPPhosphoribosylaminoimidazole-succinocarboxamide synthase/0.450
2zvcSAHPrecorrin-3 C17-methyltransferase/0.450
3bbrBHYGlutamate receptor 2/0.450
3d2pCOAAmino-acid acetyltransferase/0.450
3gviADPMalate dehydrogenase/0.450
3h3r14HCollagen type IV alpha-3-binding protein/0.450
3i60E86Mitogen-activated protein kinase 12.7.11.240.450
3p74FMNPentaerythritol tetranitrate reductase/0.450
3zrcL8BVon Hippel-Lindau disease tumor suppressor/0.450
4dptAGSMevalonate diphosphate decarboxylase/0.450
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.450
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
1ht2ADPATP-dependent protease ATPase subunit HslU/0.449
1ia1NDPDihydrofolate reductase1.5.1.30.449
1icuFMNOxygen-insensitive NAD(P)H nitroreductase/0.449
1q6yCOAFormyl-CoA:oxalate CoA-transferase/0.449
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.449
2rhrEMOPutative ketoacyl reductase1.3.10.449
2vttLZDCyclin-dependent kinase 22.7.11.220.449
2wa2SAMGenome polyprotein/0.449
2wdzNADGalactitol dehydrogenase/0.449
3eblGA4Gibberellin receptor GID1/0.449
3evbSAHGenome polyprotein2.1.1.560.449
3eyhIZATyrosine-protein kinase JAK1/0.449
3pce3HPProtocatechuate 3,4-dioxygenase alpha chain1.13.11.30.449
3pce3HPProtocatechuate 3,4-dioxygenase beta chain1.13.11.30.449
3qdlFMNOxygen-insensitive NADPH nitroreductase/0.449
4bfxZVXPantothenate kinase2.7.1.330.449
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
4fn4NADShort chain dehydrogenase/0.449
4fxfATPPyruvate kinase PKM2.7.1.400.449
4kwhNAPReductase homolog/0.449
4r3aRBFBlue-light-activated histidine kinase 22.7.13.30.449
4z24FADPutative GMC-type oxidoreductase R13510.449
4z54GDPNeuronal-specific septin-3/0.449
1a80NDP2,5-diketo-D-gluconic acid reductase A1.1.1.3460.448
1b8uNADMalate dehydrogenase/0.448
1bk0ACVIsopenicillin N synthase1.21.3.10.448
1dz6CAMCamphor 5-monooxygenase1.14.15.10.448
1eiiRTLRetinol-binding protein 2/0.448
1h48CDI2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.448
1h50FMNPentaerythritol tetranitrate reductase/0.448
1s3uTQDDihydrofolate reductase1.5.1.30.448
1zc3GNPRas-related protein Ral-A/0.448
2e17SAHDiphthine synthase/0.448
2ed5SAHDiphthine synthase/0.448
2fjeFADAdenylylsulfate reductase, subunit A (AprA)/0.448
2wezZYEBeta-secretase 13.4.23.460.448
2xhrC0PHeat shock protein HSP 90-alpha/0.448
3fwjCAMCamphor 5-monooxygenase1.14.15.10.448
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3wrmCAMCamphor 5-monooxygenase1.14.15.10.448
4o71CPBBromodomain-containing protein 4/0.448
4r1fADPDNA topoisomerase 2-alpha5.99.1.30.448
4umyNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.448
4v02ATPSite-determining protein/0.448
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.448
4zohFADPutative oxidoreductase FAD-binding subunit/0.448
5e92ANPTGF-beta receptor type-22.7.11.300.448
5ej6TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.448
1giaGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.447
1i24UPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.447
1qorNDPQuinone oxidoreductase 1/0.447
1sxjADPReplication factor C subunit 5/0.447
1uxjNADMalate dehydrogenase/0.447
2dv4SAHDiphthine synthase/0.447
2fznFADBifunctional protein PutA1.5.5.20.447
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase/0.447
2j09FMNDeoxyribodipyrimidine photo-lyase4.1.99.30.447
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.447
3dafFEG5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.447
3ddw055Glycogen phosphorylase, liver form2.4.1.10.447
3e5hGNPRas-related protein Rab-28/0.447
3ed1GA3Gibberellin receptor GID1/0.447
3ge6FMNNitroreductase/0.447
3k7mFAD6-hydroxy-L-nicotine oxidase/0.447
3rq6APRADP-dependent (S)-NAD(P)H-hydrate dehydratase/0.447
4a99FADTetX family tetracycline inactivation enzyme/0.447
4bkjSTIEpithelial discoidin domain-containing receptor 12.7.10.10.447
4e1z0MXNon-receptor tyrosine-protein kinase TYK22.7.10.20.447
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.447
4f9fGDPPutative glycosyltransferase/0.447
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.447
4o3mADPBloom syndrome protein3.6.4.120.447
5ej7TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.447
1ae1NAPTropinone reductase 1/0.446
1ai9NDPDihydrofolate reductase1.5.1.30.446
1ig1ANPDeath-associated protein kinase 12.7.11.10.446
1juvNDPDihydrofolate reductase1.5.1.30.446
1ky2GNPGTP-binding protein YPT7/0.446
1l8qADPChromosomal replication initiator protein DnaA/0.446
1llzFMNFerredoxin-dependent glutamate synthase 21.4.7.10.446
1r8cUTPCCA-adding enzyme2.7.7.720.446
1rk3VDXVitamin D3 receptor/0.446
1xdpATPPolyphosphate kinase/0.446
2hutSAHDiphthine synthase/0.446
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.446
2omeNADC-terminal-binding protein 2/0.446
2yy8SAMtRNA (cytidine(56)-2'-O)-methyltransferase/0.446
2zbaZBATrichothecene 3-O-acetyltransferase/0.446
3fhxPXLPyridoxal kinase2.7.1.350.446
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.446
3orfNADDihydropteridine reductase1.5.1.340.446
4ek1CAMCamphor 5-monooxygenase1.14.15.10.446
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.446
4fmxCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.446
4jy2FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase/0.446
4pzsACOHistone acetyltransferase p300/0.446
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.446
4zseANPEpidermal growth factor receptor2.7.10.10.446
5cnsDATRibonucleoside-diphosphate reductase 1 subunit alpha1.17.4.10.446
1dr5NAPDihydrofolate reductase1.5.1.30.445
1j4jACOAcetyltransferase2.3.10.445
1omoNADAlanine dehydrogenase/0.445
1pr9NAPL-xylulose reductase1.1.1.100.445
1xvaSAMGlycine N-methyltransferase2.1.1.200.445
1yrdCAMCamphor 5-monooxygenase1.14.15.10.445
1z5aADPType 2 DNA topoisomerase 6 subunit B/0.445
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.445
2huvSAHDiphthine synthase/0.445
2qtvGNPSmall COPII coat GTPase SAR13.6.50.445
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.445
3cppCAMCamphor 5-monooxygenase1.14.15.10.445
3s79ASDAromatase1.14.14.140.445
3t10ACPHeat shock protein HSP 90-alpha/0.445
3zhrTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.445
4c02TAKActivin receptor type-12.7.11.300.445
4c9oCAMCytochrome P450/0.445
4fmqANPMitogen-activated protein kinase 12.7.11.240.445
4fvrATPTyrosine-protein kinase JAK2/0.445
4gk2L66Ephrin type-A receptor 32.7.10.10.445
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.445
4l4fCAMCamphor 5-monooxygenase1.14.15.10.445
4lcg1WMUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.445
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.445
4z43FADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.445
5itzLOCTubulin beta-2B chain/0.445
5kjfNAJAlcohol dehydrogenase E chain1.1.1.10.445
1b5tFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.444
1disBDMDihydrofolate reductase1.5.1.30.444
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.444
1e94ANPATP-dependent protease ATPase subunit HslU/0.444
1hb1OCVIsopenicillin N synthase1.21.3.10.444
1i5bANPChemotaxis protein CheA2.7.13.30.444
1osvCHCBile acid receptor/0.444
1qvrANPChaperone protein ClpB/0.444
1ve3SAMUncharacterized protein/0.444
1wngSAHDiphthine synthase/0.444
2bu8ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.444
2bxmIMNSerum albumin/0.444
2feuCAMCamphor 5-monooxygenase1.14.15.10.444
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.444
2q5g1FAPeroxisome proliferator-activated receptor delta/0.444
2qbmCAMCamphor 5-monooxygenase1.14.15.10.444
2ql6ADPNicotinamide riboside kinase 1/0.444
2vw5BC6ATP-dependent molecular chaperone HSP82/0.444
2zuiCAMCamphor 5-monooxygenase1.14.15.10.444
3docNADGlyceraldehyde-3-phosphate dehydrogenase/0.444
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3il1B5DGlutamate receptor 2/0.444
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.444
3otwCOAPhosphopantetheine adenylyltransferase/0.444
3triNAPPyrroline-5-carboxylate reductase/0.444
3w2eNADNADH-cytochrome b5 reductase 31.6.2.20.444
3wbfNAPMeso-diaminopimelate D-dehydrogenase/0.444
4echFADPolyamine oxidase FMS1/0.444
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.444
4h4zFADBiphenyl dioxygenase ferredoxin reductase subunit/0.444
4ikeADPAdenylate kinase/0.444
4lhtCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.444
4lrjANPUncharacterized protein/0.444
4mqy2CWUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.444
4paoGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.444
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.444
4tleAGSCircadian clock protein kinase KaiC2.7.11.10.444
4udrFAD5-(hydroxymethyl)furfural oxidase/0.444
5cyoGDPSeptin-9/0.444
1cbqRE9Cellular retinoic acid-binding protein 2/0.443
1glbADPGlycerol kinase/0.443
1hdoNAPFlavin reductase (NADPH)/0.443
1kqbFMNOxygen-insensitive NAD(P)H nitroreductase/0.443
1lf3EH5Plasmepsin-23.4.23.390.443
1rj9GCPSignal recognition particle receptor FtsY/0.443
1ro98BRcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.443
1tehNADAlcohol dehydrogenase class-31.1.1.10.443
1vp6CMPCyclic nucleotide-gated potassium channel mll3241/0.443
1y4sADPChaperone protein HtpG/0.443
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
2d4vNADIsocitrate dehydrogenase [NADP]/0.443
2q59240Peroxisome proliferator-activated receptor gamma/0.443
2zawCAMCamphor 5-monooxygenase1.14.15.10.443
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.443
3bpzCMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2/0.443
3bxzADPProtein translocase subunit SecA/0.443
3gy0NAPNAD(P)-dependent oxidoreductase/0.443
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.443
3sl2ATPSensor histidine kinase WalK/0.443
4e07ACPPlasmid partitioning protein ParF/0.443
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.443
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.443
4jazSTLPeroxisome proliferator-activated receptor gamma/0.443
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.443
4mkhAP5Adenylate kinase/0.443
4nieNBHNuclear receptor ROR-gamma/0.443
4ocpADPN-acetylhexosamine 1-kinase2.7.1.1620.443
4prvADPDNA gyrase subunit B/0.443
4yswFADXanthine dehydrogenase/oxidase/0.443
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.443
1a9yUPGUDP-glucose 4-epimerase5.1.3.20.442
1i59ADPChemotaxis protein CheA2.7.13.30.442
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.442
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1j39UPGDNA beta-glucosyltransferase/0.442
1l3iSAHProbable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)/0.442
1py5PY1TGF-beta receptor type-12.7.11.300.442
1sb8UD2WbpP/0.442
1t85CAMCamphor 5-monooxygenase1.14.15.10.442
1tqf32PBeta-secretase 13.4.23.460.442
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.442
1xo2FSECyclin-dependent kinase 62.7.11.220.442
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2b7aIZATyrosine-protein kinase JAK2/0.442
2ek2SAHDiphthine synthase/0.442
2f3rG5PGuanylate kinase2.7.4.80.442
2fonFADAcyl-coenzyme A oxidase/0.442
2rlcCHDCholoylglycine hydrolase3.5.1.240.442
2xvq9DSSerum albumin/0.442
2zaxCAMCamphor 5-monooxygenase1.14.15.10.442
3a60STURibosomal protein S6 kinase beta-12.7.11.10.442
3hpqAP5Adenylate kinase/0.442
3n4mCMPcAMP-activated global transcriptional regulator CRP/0.442
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.442
3tjzGNPADP-ribosylation factor 1/0.442
3zoiM2WIsopenicillin N synthase1.21.3.10.442
4a9oA9OBromodomain-containing protein 2/0.442
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.442
4bizADPSensor histidine kinase CpxA/0.442
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.442
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
4oauADP2-5A-dependent ribonuclease3.1.260.442
4xf7ACPCarbohydrate/pyrimidine kinase, PfkB family/0.442
1axgNADAlcohol dehydrogenase E chain1.1.1.10.441
1b8vNADMalate dehydrogenase/0.441
1bdbNADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase/0.441
1bv9XV6Gag-Pol polyprotein3.4.23.160.441
1kh3ANPArgininosuccinate synthase/0.441
1m2pHNACasein kinase II subunit alpha2.7.11.10.441
1m2qMNXCasein kinase II subunit alpha2.7.11.10.441
1me8RVPInosine-5'-monophosphate dehydrogenase/0.441
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
2e15SAHDiphthine synthase/0.441
2e7zMGDAcetylene hydratase/0.441
2ek7SAHDiphthine synthase/0.441
2emuSAHDiphthine synthase/0.441
2ggsNDPdTDP-4-dehydrorhamnose reductase/0.441
2gr1FADFerredoxin reductase/0.441
2npxNADNADH peroxidase1.11.1.10.441
2rcyNAPPyrroline-5-carboxylate reductase/0.441
2v16C47Renin3.4.23.150.441
2wouZZFTGF-beta receptor type-12.7.11.300.441
3af1GDPPantothenate kinase2.7.1.330.441
3btsNADGalactose/lactose metabolism regulatory protein GAL80/0.441
3djjFADGlutathione reductase, mitochondrial1.8.1.70.441
3icsADPCoenzyme A disulfide reductase/0.441
3pghFLPProstaglandin G/H synthase 21.14.99.10.441
3vfa031Gag-Pol polyprotein3.4.23.160.441
3zlx5EZDual specificity mitogen-activated protein kinase kinase 12.7.12.20.441
4e4m0NHTyrosine-protein kinase JAK2/0.441
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4jb1FADUDP-N-acetylenolpyruvoylglucosamine reductase/0.441
4kkyCAMCamphor 5-monooxygenase1.14.15.10.441
4wxxSAHDNA (cytosine-5)-methyltransferase 12.1.1.370.441
5kgpACOPredicted acetyltransferase/0.441
1hdgNADGlyceraldehyde-3-phosphate dehydrogenase/0.440
1pjcNADAlanine dehydrogenase/0.440
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1t2bCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.440
1yhnGTPRas-related protein Rab-7a/0.440
1zrqFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.440
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.440
2ffqGSPRas-related protein Rab-6B/0.440
2iviACWIsopenicillin N synthase1.21.3.10.440
2owuSAHDiphthine synthase/0.440
2y3rTIRTamL/0.440
3a7rLAQLipoate-protein ligase A6.3.1.200.440
3b70NAPEnoyl reductase LovC10.440
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3juqAKDPhenazine biosynthesis protein A/B/0.440
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3lu1NADUDP-N-acetylglucosamine 4-epimerase/0.440
3pcg4HPProtocatechuate 3,4-dioxygenase alpha chain1.13.11.30.440
3pcg4HPProtocatechuate 3,4-dioxygenase beta chain1.13.11.30.440
3uhmRFNUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.440
3w4yFADMitochondrial FAD-linked sulfhydryl oxidase ERV11.8.3.20.440
4ajn88VL-lactate dehydrogenase A chain1.1.1.270.440
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
4i8x6P3L-lactate dehydrogenase A chain1.1.1.270.440
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.440
4kl9NDPDihydrofolate reductase1.5.1.30.440
4q72FADBifunctional protein PutA/0.440
4y9qC2EUncharacterized protein/0.440
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.440