sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1w2d | ADP | Inositol-trisphosphate 3-kinase A | 2.7.1.127 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1w2d | ADP | Inositol-trisphosphate 3-kinase A | 2.7.1.127 | 1.000 | |
| 1w2c | ANP | Inositol-trisphosphate 3-kinase A | 2.7.1.127 | 0.688 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.555 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.509 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.507 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.505 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.503 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.503 | |
| 1iah | ADP | Transient receptor potential cation channel subfamily M member 7 | 2.7.11.1 | 0.502 | |
| 3rl3 | 5GP | Metallophosphoesterase MPPED2 | 3.1 | 0.502 | |
| 1g4s | TPS | Thiamine-phosphate synthase | / | 0.500 | |
| 1gy3 | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.498 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 3sl2 | ATP | Sensor histidine kinase WalK | / | 0.492 | |
| 2bil | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.490 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.490 | |
| 4o4f | ATP | Kinase | / | 0.489 | |
| 2xvw | 9NR | Serum albumin | / | 0.488 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.488 | |
| 2fsz | OHT | Estrogen receptor beta | / | 0.487 | |
| 4j52 | 1J3 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.486 | |
| 5ckw | ANP | Uncharacterized protein | / | 0.486 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.485 | |
| 2j9g | ADP | Biotin carboxylase | 6.3.4.14 | 0.485 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.485 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.484 | |
| 2xf3 | J01 | Uncharacterized protein | / | 0.482 | |
| 2xnm | WGZ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.482 | |
| 3uvv | REA | Retinoic acid receptor RXR-alpha | / | 0.482 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.482 | |
| 2qgt | EED | Estrogen receptor | / | 0.481 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.481 | |
| 3zsg | T75 | Mitogen-activated protein kinase 14 | / | 0.481 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.480 | |
| 3zqt | TES | Androgen receptor | / | 0.479 | |
| 4f1m | ACP | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 | 0.479 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.479 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.478 | |
| 1yin | CM3 | Estrogen receptor | / | 0.478 | |
| 2bj4 | OHT | Estrogen receptor | / | 0.478 | |
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.478 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.477 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.477 | |
| 3fzs | B96 | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.476 | |
| 1yi4 | ADN | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.474 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.474 | |
| 2p15 | EZT | Estrogen receptor | / | 0.474 | |
| 2qe4 | JJ3 | Estrogen receptor | / | 0.474 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3x06 | 5GP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.474 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.474 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.474 | |
| 1i59 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.473 | |
| 1ove | 358 | Mitogen-activated protein kinase 14 | / | 0.473 | |
| 3dko | IHZ | Ephrin type-A receptor 7 | 2.7.10.1 | 0.473 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.473 | |
| 4oav | ACP | 2-5A-dependent ribonuclease | 3.1.26 | 0.473 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.472 | |
| 4pxm | EST | Estrogen receptor | / | 0.472 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.471 | |
| 2q70 | DC8 | Estrogen receptor | / | 0.471 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.471 | |
| 3hy4 | N5G | 5-formyltetrahydrofolate cyclo-ligase | 6.3.3.2 | 0.471 | |
| 3jxw | LXG | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.471 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.471 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.471 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.471 | |
| 1i58 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.470 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 1u9e | 397 | Estrogen receptor beta | / | 0.470 | |
| 2g44 | T3O | Estrogen receptor | / | 0.470 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.470 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.470 | |
| 3x04 | GNP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.470 | |
| 1lco | PPY | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.469 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1nde | MON | Estrogen receptor beta | / | 0.469 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.469 | |
| 3tpt | ADP | Serine/threonine-protein kinase toxin HipA | / | 0.469 | |
| 4pkw | GM6 | Lethal factor | 3.4.24.83 | 0.469 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.469 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.469 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.469 | |
| 1i58 | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.468 | |
| 1xws | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.468 | |
| 3cse | N22 | Uncharacterized protein | / | 0.468 | |
| 3eel | 53T | Uncharacterized protein | / | 0.468 | |
| 4g31 | 0WH | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.468 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 4yx6 | FMN | Omega-3 polyunsaturated fatty acid synthase subunit PfaD | / | 0.468 | |
| 2i0z | FAD | NAD(FAD)-utilizing dehydrogenases | / | 0.467 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.467 | |
| 3q2m | CKI | Spectinomycin phosphotransferase | / | 0.467 | |
| 4uoh | ADP | Nucleoside diphosphate kinase | / | 0.467 | |
| 1iky | MSD | Gag-Pol polyprotein | 2.7.7.49 | 0.466 | |
| 1p16 | GTP | mRNA-capping enzyme subunit alpha | 2.7.7.50 | 0.466 | |
| 2pog | WST | Estrogen receptor | / | 0.466 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.466 | |
| 3c1x | CKK | Hepatocyte growth factor receptor | 2.7.10.1 | 0.466 | |
| 3g7f | UQ1 | Reaction center protein L chain | / | 0.466 | |
| 4dm6 | TTB | Retinoic acid receptor beta | / | 0.466 | |
| 4el9 | AFE | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.466 | |
| 4q15 | HFG | Proline--tRNA ligase | 6.1.1.15 | 0.466 | |
| 4zhi | ADP | Kinesin-like protein KIF11 | / | 0.466 | |
| 1fby | REA | Retinoic acid receptor RXR-alpha | / | 0.465 | |
| 2od7 | A1R | NAD-dependent protein deacetylase HST2 | 3.5.1 | 0.465 | |
| 2pup | ADP | Methylthioribose kinase | 2.7.1.100 | 0.465 | |
| 2xae | ADP | Kinesin-like protein KIF11 | / | 0.465 | |
| 2z4s | ADP | Chromosomal replication initiator protein DnaA | / | 0.465 | |
| 3cem | AVD | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.465 | |
| 3hzi | ATP | Serine/threonine-protein kinase toxin HipA | / | 0.465 | |
| 3p9t | TCL | Repressor | / | 0.465 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.465 | |
| 4gqk | ADP | Actin cross-linking toxin VgrG1 | / | 0.465 | |
| 4iwc | 1GV | Estrogen receptor | / | 0.465 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1xls | REA | Retinoic acid receptor RXR-alpha | / | 0.464 | |
| 2a19 | ANP | Interferon-induced, double-stranded RNA-activated protein kinase | 2.7.11.1 | 0.464 | |
| 2poq | ISD | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 1.3.1.20 | 0.464 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3gc7 | B45 | Mitogen-activated protein kinase 14 | / | 0.464 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.464 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.464 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.464 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 2xvv | 9DN | Serum albumin | / | 0.463 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.463 | |
| 3oll | EST | Estrogen receptor beta | / | 0.463 | |
| 4ivy | 1GT | Estrogen receptor | / | 0.463 | |
| 5kf2 | COA | Predicted acetyltransferase | / | 0.463 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1mc5 | AHE | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.462 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1uof | PNN | Deacetoxycephalosporin C synthase | 1.14.20.1 | 0.462 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.462 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.462 | |
| 2p4i | MR9 | Angiopoietin-1 receptor | 2.7.10.1 | 0.462 | |
| 2x20 | PID | Peridinin-chlorophyll a-binding protein 1, chloroplastic | / | 0.462 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.462 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.461 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 3bbf | GDP | Nucleoside diphosphate kinase B | 2.7.4.6 | 0.461 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.461 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.461 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.461 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.461 | |
| 4ixd | 1HV | Integrin alpha-L | / | 0.461 | |
| 4jau | ADP | Sensor histidine kinase | / | 0.461 | |
| 4n70 | 2HX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.461 | |
| 4zas | TYD | CalS13 | / | 0.461 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.461 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.461 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.461 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.461 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1i5a | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.460 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 1y56 | FMN | Uncharacterized protein | / | 0.460 | |
| 1y56 | FMN | 382aa long hypothetical sarcosine oxidase | / | 0.460 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.460 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 3hx3 | RET | Retinaldehyde-binding protein 1 | / | 0.460 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.460 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.459 | |
| 2j7y | E3O | Estrogen receptor beta | / | 0.459 | |
| 2x9v | TMQ | Pteridine reductase | / | 0.459 | |
| 2ylp | TES | Androgen receptor | / | 0.459 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.459 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4l9z | COA | L-malyl-CoA/beta-methylmalyl-CoA lyase | 4.1.3.24 | 0.459 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.459 | |
| 5dxg | EST | Estrogen receptor | / | 0.459 | |
| 1mo9 | KPC | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.458 | |
| 2itt | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.458 | |
| 2pun | ACP | Methylthioribose kinase | 2.7.1.100 | 0.458 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.458 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1yy4 | 4NA | Estrogen receptor beta | / | 0.457 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.457 | |
| 2oh4 | GIG | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.457 | |
| 2qqf | A1R | NAD-dependent protein deacetylase HST2 | 3.5.1 | 0.457 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.457 | |
| 3i58 | 7NA | 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase | / | 0.457 | |
| 3l03 | 4OH | Estrogen receptor | / | 0.457 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.457 | |
| 4a4x | JUP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.457 | |
| 4ie6 | UN9 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.457 | |
| 4iw8 | KN3 | Estrogen receptor | / | 0.457 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.457 | |
| 1g50 | EST | Estrogen receptor | / | 0.456 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.456 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2pui | ADP | Methylthioribose kinase | 2.7.1.100 | 0.456 | |
| 2rku | R78 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.456 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.456 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.456 | |
| 3tm4 | SAM | Uncharacterized protein | / | 0.456 | |
| 4uof | DAT | Nucleoside diphosphate kinase | / | 0.456 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.455 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1n71 | COA | Aac(6')-Ii protein | / | 0.455 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.455 | |
| 1x78 | 244 | Estrogen receptor beta | / | 0.455 | |
| 2b1z | 17M | Estrogen receptor | / | 0.455 | |
| 2pg2 | ADP | Kinesin-like protein KIF11 | / | 0.455 | |
| 3be2 | RAJ | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.455 | |
| 3fyv | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 3p7a | P7A | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.455 | |
| 3vi7 | CBD | Hematopoietic prostaglandin D synthase | / | 0.455 | |
| 3wv7 | ADP | Hmd co-occurring protein HcgE | / | 0.455 | |
| 4ie0 | PD2 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.455 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.455 | |
| 4l8u | 9AZ | Serum albumin | / | 0.455 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 4qij | 1HA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.455 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1e2j | THM | Thymidine kinase | / | 0.454 | |
| 1fd0 | 254 | Retinoic acid receptor gamma | / | 0.454 | |
| 1s9q | OHT | Estrogen-related receptor gamma | / | 0.454 | |
| 1xp9 | AIJ | Estrogen receptor | / | 0.454 | |
| 1y6b | AAX | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.454 | |
| 1z4i | UMP | 5'(3')-deoxyribonucleotidase, mitochondrial | 3.1.3 | 0.454 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2osc | MUH | Angiopoietin-1 receptor | 2.7.10.1 | 0.454 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.454 | |
| 2w5b | AGS | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.454 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.454 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.454 | |
| 3cwk | REA | Cellular retinoic acid-binding protein 2 | / | 0.454 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3icr | COA | Coenzyme A disulfide reductase | / | 0.454 | |
| 3qly | 55V | Uncharacterized protein | / | 0.454 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.454 | |
| 3zs5 | SB2 | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 4h1j | 0YH | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.454 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.454 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4pl9 | ADP | Ethylene receptor 1 | / | 0.454 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.453 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.453 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.453 | |
| 2bns | MST | Reaction center protein L chain | / | 0.453 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.453 | |
| 2jbl | SMA | Reaction center protein L chain | / | 0.453 | |
| 2puu | G2G | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3epy | COA | Acyl-CoA-binding domain-containing protein 7 | / | 0.453 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4j24 | EST | Estrogen receptor beta | / | 0.453 | |
| 4qkn | JMS | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.453 | |
| 1fgi | SU1 | Fibroblast growth factor receptor 1 | / | 0.452 | |
| 1qnf | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.452 | |
| 2bnp | MST | Reaction center protein L chain | / | 0.452 | |
| 2imk | GTX | AGAP009194-PA | / | 0.452 | |
| 2yhd | TES | Androgen receptor | / | 0.452 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.452 | |
| 3huc | G97 | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.452 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4j26 | EST | Estrogen receptor beta | / | 0.452 | |
| 4jrn | ANP | Rhoptry kinase family protein | / | 0.452 | |
| 1g6c | IFP | Thiamine-phosphate synthase | / | 0.451 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.451 | |
| 2a8s | GTP | U8 snoRNA-decapping enzyme | / | 0.451 | |
| 2i9p | NAD | 3-hydroxyisobutyrate dehydrogenase, mitochondrial | 1.1.1.31 | 0.451 | |
| 2wqo | VGK | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.451 | |
| 2yat | EEU | Estrogen receptor | / | 0.451 | |
| 3eej | 53R | Uncharacterized protein | / | 0.451 | |
| 3fzt | 4JZ | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.451 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.451 | |
| 3kdi | A8S | Abscisic acid receptor PYL2 | / | 0.451 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.451 | |
| 4a2j | AS0 | Progesterone receptor | / | 0.451 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 4nks | 2M2 | Fibroblast growth factor receptor 1 | / | 0.451 | |
| 5dp2 | NAP | CurF | / | 0.451 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.450 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.450 | |
| 1u3s | 797 | Estrogen receptor beta | / | 0.450 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.450 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.450 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 3i64 | DNA | 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase | / | 0.450 | |
| 3orm | AGS | Serine/threonine protein kinase | / | 0.450 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 4dk5 | 0KO | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 4iw6 | 1GU | Estrogen receptor | / | 0.450 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 5bsr | COA | 4-coumarate--CoA ligase 2 | 6.2.1.12 | 0.450 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1mru | AGS | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.449 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1u0w | STL | Chalcone synthase 2 | 2.3.1.74 | 0.449 | |
| 2bxq | IMN | Serum albumin | / | 0.449 | |
| 2i0e | PDS | Protein kinase C beta type | 2.7.11.13 | 0.449 | |
| 2jj3 | JJ3 | Estrogen receptor beta | / | 0.449 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.449 | |
| 3nmv | PYV | Abscisic acid receptor PYL2 | / | 0.449 | |
| 4a4l | 939 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.449 | |
| 4ap7 | F47 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.449 | |
| 4azw | ATP | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.449 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.449 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.449 | |
| 1k74 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.448 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.448 | |
| 2ati | IHU | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.448 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 2lbd | REA | Retinoic acid receptor gamma | / | 0.448 | |
| 2py3 | ACP | Fibroblast growth factor receptor 2 | / | 0.448 | |
| 2xk3 | XK3 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.448 | |
| 2xkf | BX1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.448 | |
| 3d5w | ADP | Serine/threonine-protein kinase PLK | / | 0.448 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 3q95 | ESL | Estrogen receptor | / | 0.448 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.448 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.448 | |
| 3umx | Q18 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 3x0a | 5GP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.448 | |
| 4lsj | LSJ | Glucocorticoid receptor | / | 0.448 | |
| 4xdm | GDM | Heat shock cognate 90 kDa protein | / | 0.448 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.448 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 1x7e | 244 | Estrogen receptor | / | 0.447 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.447 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.447 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.447 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.447 | |
| 2nv7 | 555 | Estrogen receptor beta | / | 0.447 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2ydv | NEC | Adenosine receptor A2a | / | 0.447 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.447 | |
| 3kqj | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.447 | |
| 3kzo | AN0 | N-acetylornithine carbamoyltransferase | 2.1.3.9 | 0.447 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.447 | |
| 3new | 3NE | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3zk6 | H1I | Bcl-2-like protein 1 | / | 0.447 | |
| 4agw | NG7 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.447 | |
| 4aos | NAP | Steroid monooxygenase | / | 0.447 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.447 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4tqq | UQ1 | Reaction center protein L chain | / | 0.447 | |
| 5dq8 | FLF | Transcriptional enhancer factor TEF-4 | / | 0.447 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.446 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1fm9 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.446 | |
| 1g6c | TZP | Thiamine-phosphate synthase | / | 0.446 | |
| 1kru | IPT | Galactoside O-acetyltransferase | 2.3.1.18 | 0.446 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1x7j | GEN | Estrogen receptor beta | / | 0.446 | |
| 1zaf | 789 | Estrogen receptor beta | / | 0.446 | |
| 1zzl | TZY | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.446 | |
| 2bfp | H4B | Pteridine reductase 1 | 1.5.1.33 | 0.446 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2piv | DHT | Androgen receptor | / | 0.446 | |
| 3oq1 | 3OQ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.446 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.446 | |
| 4eil | CB3 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.446 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.446 | |
| 4m8e | 29V | Retinoic acid receptor RXR-alpha | / | 0.446 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 1ne6 | SP1 | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.445 | |
| 1zyd | ATP | eIF-2-alpha kinase GCN2 | / | 0.445 | |
| 2c3d | COM | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.445 | |
| 2fai | 459 | Estrogen receptor | / | 0.445 | |
| 2g5o | DRQ | Estrogen receptor | / | 0.445 | |
| 2ga9 | AGS | Poly(A) polymerase catalytic subunit | 2.7.7.19 | 0.445 | |
| 2np8 | CC3 | Aurora kinase A | 2.7.11.1 | 0.445 | |
| 2og8 | 1N8 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.445 | |
| 2xke | WI2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.445 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.445 | |
| 3dqw | AGS | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.445 | |
| 3eek | 53S | Uncharacterized protein | / | 0.445 | |
| 3nsz | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.445 | |
| 3oom | 507 | Activin receptor type-1 | 2.7.11.30 | 0.445 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.445 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.445 | |
| 3w0p | ADP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.445 | |
| 4g2i | 0VQ | Vitamin D3 receptor | / | 0.445 | |
| 4i2p | G73 | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 4iv2 | 1GR | Estrogen receptor | / | 0.445 | |
| 4oau | ADP | 2-5A-dependent ribonuclease | 3.1.26 | 0.445 | |
| 4qx5 | CMP | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.445 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.445 | |
| 1a8t | 061 | Metallo-beta-lactamase type 2 | / | 0.444 | |
| 1e7a | PFL | Serum albumin | / | 0.444 | |
| 1ivr | CBA | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.444 | |
| 1lb9 | DNQ | Glutamate receptor 2 | / | 0.444 | |
| 1tlc | F89 | Thymidylate synthase | / | 0.444 | |
| 1uom | PTI | Estrogen receptor | / | 0.444 | |
| 1xmm | M7G | m7GpppX diphosphatase | 3.6.1.59 | 0.444 | |
| 2c3i | IYZ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 2owb | 626 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.444 | |
| 2pkl | DHT | Androgen receptor | / | 0.444 | |
| 2pz5 | ACP | Fibroblast growth factor receptor 2 | / | 0.444 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3gie | ACP | Sensor histidine kinase DesK | 2.7.13.3 | 0.444 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 3q6j | KPC | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.444 | |
| 3zy6 | GFB | GDP-fucose protein O-fucosyltransferase 1 | 2.4.1.221 | 0.444 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.444 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 4eh5 | 0OM | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.444 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4ivq | I43 | Thymidine kinase | / | 0.444 | |
| 4kod | ADP | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.444 | |
| 5cuq | NSC | Genome polyprotein | / | 0.444 | |
| 1dub | CAA | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 | 0.443 | |
| 1fr8 | GDU | Beta-1,4-galactosyltransferase 1 | / | 0.443 | |
| 1l8q | ADP | Chromosomal replication initiator protein DnaA | / | 0.443 | |
| 1n3r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.443 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1r9o | FLP | Cytochrome P450 2C9 | / | 0.443 | |
| 1tez | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.443 | |
| 1tl1 | H18 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1yho | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2ahv | COA | Acetate CoA-transferase YdiF | 2.8.3.8 | 0.443 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.443 | |
| 2pl0 | STI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.443 | |
| 2pzp | ACP | Fibroblast growth factor receptor 2 | / | 0.443 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3bgp | VX1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 3cth | 319 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.443 | |
| 3d74 | NBB | Pheromone-binding protein ASP1 | / | 0.443 | |
| 3dat | MTX | Dihydrofolate reductase | / | 0.443 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 3rr3 | FLR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.443 | |
| 3tl1 | JRO | Putative polyketide cyclase | / | 0.443 | |
| 3uvp | 048 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.443 | |
| 3zra | ORB | Progesterone receptor | / | 0.443 | |
| 4g1n | NZT | Pyruvate kinase PKM | 2.7.1.40 | 0.443 | |
| 4lg5 | A1O | Abscisic acid receptor PYL2 | / | 0.443 | |
| 4o4e | ATP | Kinase | / | 0.443 | |
| 5dgz | L20 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 1err | RAL | Estrogen receptor | / | 0.442 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.442 | |
| 1x7r | GEN | Estrogen receptor | / | 0.442 | |
| 1zky | 689 | Estrogen receptor | / | 0.442 | |
| 2bxm | IMN | Serum albumin | / | 0.442 | |
| 2f4j | VX6 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.442 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 2xkd | T3M | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.442 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.442 | |
| 2z1x | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.442 | |
| 2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.442 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.442 | |
| 3c3e | FO1 | 2-phospho-L-lactate transferase | / | 0.442 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 3cly | ACP | Fibroblast growth factor receptor 2 | / | 0.442 | |
| 3cyz | 9OD | Pheromone-binding protein ASP1 | / | 0.442 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 3iis | PID | Peridinin-chlorophyll a-binding protein 1, chloroplastic | / | 0.442 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
| 3tub | FPU | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.442 | |
| 4dm8 | REA | Retinoic acid receptor beta | / | 0.442 | |
| 4ea1 | 3RX | Dehydrosqualene synthase | / | 0.442 | |
| 4eer | FMN | Phototropin-2 | 2.7.11.1 | 0.442 | |
| 4f1s | F1S | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.442 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.442 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.442 | |
| 4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.442 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 1ne4 | RP1 | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.441 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.441 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1xve | 3BB | Methane monooxygenase component A beta chain | 1.14.13.25 | 0.441 | |
| 2oax | SNL | Mineralocorticoid receptor | / | 0.441 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.441 | |
| 2pix | DHT | Androgen receptor | / | 0.441 | |
| 2pul | ACP | Methylthioribose kinase | 2.7.1.100 | 0.441 | |
| 2z52 | H23 | Geranylgeranyl pyrophosphate synthase | / | 0.441 | |
| 2ze2 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3cx5 | SMA | Cytochrome b | / | 0.441 | |
| 3el7 | PD3 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.441 | |
| 3fnl | SHA | Lactoperoxidase | / | 0.441 | |
| 3gub | GUB | Death-associated protein kinase 1 | 2.7.11.1 | 0.441 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.441 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3up3 | XCA | aceDAF-12 | / | 0.441 | |
| 4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.441 | |
| 4k33 | ACP | Fibroblast growth factor receptor 3 | 2.7.10.1 | 0.441 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.441 | |
| 1e3k | R18 | Progesterone receptor | / | 0.440 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.440 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1ogx | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.440 | |
| 1s6q | TPB | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 1wpg | ADP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.440 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2ao6 | R18 | Androgen receptor | / | 0.440 | |
| 2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 2cdc | NAP | Glucose 1-dehydrogenase | / | 0.440 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.440 | |
| 3dcv | 55E | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 3htj | ET | EbrA repressor | / | 0.440 | |
| 3hv6 | R39 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3lm4 | HPX | Catechol 2,3-dioxygenase | / | 0.440 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 3r02 | UNM | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 3tqa | NDP | Dihydrofolate reductase | / | 0.440 | |
| 3vi5 | M4M | Hematopoietic prostaglandin D synthase | / | 0.440 | |
| 4dma | 0L8 | Estrogen receptor | / | 0.440 | |
| 4ffl | ADP | Uncharacterized protein | / | 0.440 | |
| 4h38 | 0YX | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 4je5 | PLP | Aromatic/aminoadipate aminotransferase 1 | 2.6.1.39 | 0.440 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.440 | |
| 4okk | U5P | 3'-5' exoribonuclease MT2234.1 | / | 0.440 | |
| 4olf | HFG | Proline--tRNA ligase | 6.1.1.15 | 0.440 | |
| 4xhg | ADP | Uncharacterized protein | / | 0.440 | |
| 5dx3 | EST | Estrogen receptor | / | 0.440 |