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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3zlx5EZDual specificity mitogen-activated protein kinase kinase 12.7.12.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3zlx5EZDual specificity mitogen-activated protein kinase kinase 12.7.12.21.000
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.619
4h3qANPMitogen-activated protein kinase 12.7.11.240.534
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.533
3eljGS7Mitogen-activated protein kinase 82.7.11.240.529
5e8ySTUTGF-beta receptor type-22.7.11.300.520
2b7aIZATyrosine-protein kinase JAK2/0.515
2p33J07Mitogen-activated protein kinase 102.7.11.240.515
3w8qAGSDual specificity mitogen-activated protein kinase kinase 12.7.12.20.513
3nieANPMitogen-activated protein kinase/0.510
4hge15VTyrosine-protein kinase JAK2/0.502
1pmn984Mitogen-activated protein kinase 102.7.11.240.501
1y91CT9Cyclin-dependent kinase 22.7.11.220.501
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.501
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.500
3ggfGVDSerine/threonine-protein kinase 26/0.499
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.499
2y9qANPMitogen-activated protein kinase 12.7.11.240.498
3le62BZCyclin-dependent kinase 22.7.11.220.498
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.498
5e92ANPTGF-beta receptor type-22.7.11.300.498
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.497
3ormAGSSerine/threonine protein kinase/0.497
4j95ACPFibroblast growth factor receptor 2/0.496
2xrwANPMitogen-activated protein kinase 82.7.11.240.495
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.494
4y93746Tyrosine-protein kinase/0.494
2xa4AZ5Tyrosine-protein kinase JAK2/0.493
4btjADPTau-tubulin kinase 12.7.11.10.492
2ijmATPFocal adhesion kinase 12.7.10.20.490
3cgfJNFMitogen-activated protein kinase 102.7.11.240.488
3cgoJNOMitogen-activated protein kinase 102.7.11.240.488
3gubGUBDeath-associated protein kinase 12.7.11.10.488
3sheI85MAP kinase-activated protein kinase 32.7.11.10.488
3zls92PDual specificity mitogen-activated protein kinase kinase 12.7.12.20.488
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.488
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.487
2zdt46CMitogen-activated protein kinase 102.7.11.240.487
3zlwMT8Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.487
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.487
2vttLZDCyclin-dependent kinase 22.7.11.220.486
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.486
4nifANPMitogen-activated protein kinase 12.7.11.240.485
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.484
3kvxFMYMitogen-activated protein kinase 102.7.11.240.484
3oroAGSSerine/threonine protein kinase/0.484
2pvnP63Casein kinase II subunit alpha2.7.11.10.483
3lfqA28Cyclin-dependent kinase 22.7.11.220.483
3oriAGSSerine/threonine protein kinase/0.483
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.483
3pxkPXKFocal adhesion kinase 12.7.10.20.482
3r83Z14Cyclin-dependent kinase 22.7.11.220.482
3rvg17PTyrosine-protein kinase JAK2/0.482
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.482
3iok1P6Tyrosine-protein kinase JAK2/0.481
3rk708ZCyclin-dependent kinase 22.7.11.220.481
4qnyANPMitogen activated protein kinase, putative/0.481
4ux9ANPMitogen-activated protein kinase 82.7.11.240.481
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.480
3lfnA27Cyclin-dependent kinase 22.7.11.220.480
3rk507ZCyclin-dependent kinase 22.7.11.220.480
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.480
4wsqKSAAP2-associated protein kinase 12.7.11.10.480
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.479
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.479
4aqc88ATyrosine-protein kinase JAK2/0.479
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.479
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.478
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.478
4acm7YGCyclin-dependent kinase 22.7.11.220.478
4ivb1J5Tyrosine-protein kinase JAK1/0.478
2x1nX1NCyclin-dependent kinase 22.7.11.220.477
3sw719KCyclin-dependent kinase 22.7.11.220.477
4i22IREEpidermal growth factor receptor2.7.10.10.477
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.476
2xs0ANPMitogen-activated protein kinase 82.7.11.240.476
4jia1K3Tyrosine-protein kinase JAK2/0.476
1di8DTQCyclin-dependent kinase 22.7.11.220.475
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.475
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.475
3s1h56ZCyclin-dependent kinase 22.7.11.220.475
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
2bhhRYUCyclin-dependent kinase 22.7.11.220.474
2w06FRVCyclin-dependent kinase 22.7.11.220.474
3gu83GUDeath-associated protein kinase 12.7.11.10.474
3rpv26ZCyclin-dependent kinase 22.7.11.220.474
4dymIYZActivin receptor type-12.7.11.300.474
3orkAGSSerine/threonine protein kinase/0.473
3rni21ZCyclin-dependent kinase 22.7.11.220.473
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.472
4fv6E57Mitogen-activated protein kinase 12.7.11.240.472
4lfiGNPCasein kinase II subunit alpha2.7.11.10.472
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.472
5cnnANPEpidermal growth factor receptor2.7.10.10.472
1g5sI17Cyclin-dependent kinase 22.7.11.220.471
1gqtACPRibokinase/0.471
3gu7ADPDeath-associated protein kinase 12.7.11.10.471
3nynSGVG protein-coupled receptor kinase 62.7.11.160.471
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.471
1bygSTUTyrosine-protein kinase CSK/0.470
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.470
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.470
1h1s4SPCyclin-dependent kinase 22.7.11.220.469
1ke7LS3Cyclin-dependent kinase 22.7.11.220.469
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.469
3dfcANPDeath-associated protein kinase 12.7.11.10.469
3lpbNVBTyrosine-protein kinase JAK2/0.469
1e9hINRCyclin-dependent kinase 22.7.11.220.468
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.468
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.468
3poz03PEpidermal growth factor receptor2.7.10.10.468
3q43D66M1 family aminopeptidase3.4.110.468
3r7yZ04Cyclin-dependent kinase 22.7.11.220.468
3ttjJBIMitogen-activated protein kinase 102.7.11.240.468
4bcoT6QCyclin-dependent kinase 22.7.11.220.468
4ek816KCyclin-dependent kinase 22.7.11.220.468
2a4lRRCCyclin-dependent kinase 22.7.11.220.467
2h96893Mitogen-activated protein kinase 82.7.11.240.467
2xneASHAurora kinase A2.7.11.10.467
3qtuX44Cyclin-dependent kinase 22.7.11.220.467
3rpo24ZCyclin-dependent kinase 22.7.11.220.467
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.467
4fks46KCyclin-dependent kinase 22.7.11.220.467
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.466
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.466
3r8lZ30Cyclin-dependent kinase 22.7.11.220.466
4fmqANPMitogen-activated protein kinase 12.7.11.240.466
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.466
1oiyN41Cyclin-dependent kinase 22.7.11.220.465
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.465
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.465
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.465
1aq1STUCyclin-dependent kinase 22.7.11.220.464
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.464
1oi9N20Cyclin-dependent kinase 22.7.11.220.464
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.464
3begANPSRSF protein kinase 12.7.11.10.464
3i60E86Mitogen-activated protein kinase 12.7.11.240.464
3rm618ZCyclin-dependent kinase 22.7.11.220.464
3rmf20ZCyclin-dependent kinase 22.7.11.220.464
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.464
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.464
5cnoANPEpidermal growth factor receptor2.7.10.10.464
1h1r6CPCyclin-dependent kinase 22.7.11.220.463
2c6lDT4Cyclin-dependent kinase 22.7.11.220.463
3qx2X63Cyclin-dependent kinase 22.7.11.220.463
3r9dX6BCyclin-dependent kinase 22.7.11.220.463
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.463
4dgnLU2Casein kinase II subunit alpha2.7.11.10.463
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.462
2iw84SPCyclin-dependent kinase 22.7.11.220.462
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.462
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.462
3pe2E1BCasein kinase II subunit alpha2.7.11.10.462
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.462
2p83MR0Beta-secretase 13.4.23.460.461
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.461
3gu6ADPDeath-associated protein kinase 12.7.11.10.461
3hmm855TGF-beta receptor type-12.7.11.300.461
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.461
3qtrX36Cyclin-dependent kinase 22.7.11.220.461
4c58824Cyclin-G-associated kinase2.7.11.10.461
4fod0UVALK tyrosine kinase receptor2.7.10.10.461
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.461
5e8xSTUTGF-beta receptor type-12.7.11.300.461
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.460
1oirHDYCyclin-dependent kinase 22.7.11.220.460
2cchATPCyclin-dependent kinase 22.7.11.220.460
2q59240Peroxisome proliferator-activated receptor gamma/0.460
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.460
3t8oATPRhodopsin kinase/0.460
4fko20KCyclin-dependent kinase 22.7.11.220.460
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.460
4ix5ANPUncharacterized protein/0.460
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.460
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.460
4u03GTPCyclic GMP-AMP synthase/0.460
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.460
1bxoPP7Penicillopepsin-13.4.23.200.459
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
2b52D42Cyclin-dependent kinase 22.7.11.220.459
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.459
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.459
4g6hNAIRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.459
4ijp1EHSerine/threonine-protein kinase PRP4 homolog2.7.11.10.459
4k33ACPFibroblast growth factor receptor 32.7.10.10.459
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.458
1ke6LS2Cyclin-dependent kinase 22.7.11.220.458
1pmv537Mitogen-activated protein kinase 102.7.11.240.458
2c6tDT5Cyclin-dependent kinase 22.7.11.220.458
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.458
3k5uPFQAurora kinase A2.7.11.10.458
3qqlX03Cyclin-dependent kinase 22.7.11.220.458
3qzhX69Cyclin-dependent kinase 22.7.11.220.458
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.458
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.458
1eh4IC1Casein kinase I homolog 12.7.11.10.457
3a4vNADNDP-sugar epimerase/0.457
3w32W32Epidermal growth factor receptor2.7.10.10.457
3w33W19Epidermal growth factor receptor2.7.10.10.457
4ambDUDPutative glycosyl transferase/0.457
4btmF8ETau-tubulin kinase 12.7.11.10.457
4f650S9Fibroblast growth factor receptor 1/0.457
4fv8E63Mitogen-activated protein kinase 12.7.11.240.457
4g7gVFVLanosterol 14-alpha-demethylase/0.457
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.457
4zseANPEpidermal growth factor receptor2.7.10.10.457
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
1bwsNDPGDP-L-fucose synthase/0.456
1jnkANPMitogen-activated protein kinase 102.7.11.240.456
1xddAAYIntegrin alpha-L/0.456
2c5yMTWCyclin-dependent kinase 22.7.11.220.456
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.456
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.456
2xmyCDKCyclin-dependent kinase 22.7.11.220.456
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.456
3be9P04Casein kinase II subunit alpha2.7.11.10.456
3lxpIZANon-receptor tyrosine-protein kinase TYK22.7.10.20.456
3sw418KCyclin-dependent kinase 22.7.11.220.456
3zdu38RCyclin-dependent kinase-like 32.7.11.220.456
4bv9NDPKetimine reductase mu-crystallin1.5.1.250.456
4eon1ROCyclin-dependent kinase 22.7.11.220.456
4ix6ADPUncharacterized protein/0.456
1u54ACPActivated CDC42 kinase 1/0.455
1w0xOLOCyclin-dependent kinase 22.7.11.220.455
2b53D23Cyclin-dependent kinase 22.7.11.220.455
3gw9VNILanosterol 14-alpha-demethylase/0.455
3mtfA3FActivin receptor type-12.7.11.300.455
3pxyJWSCyclin-dependent kinase 22.7.11.220.455
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.455
4btjATPTau-tubulin kinase 12.7.11.10.455
4c57FEFCyclin-G-associated kinase2.7.11.10.455
4erwSTUCyclin-dependent kinase 22.7.11.220.455
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.455
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.455
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.455
5dr6SKEAurora kinase A2.7.11.10.455
5drdATPAurora kinase A2.7.11.10.455
1h1pCMGCyclin-dependent kinase 22.7.11.220.454
1m2pHNACasein kinase II subunit alpha2.7.11.10.454
1pxlCK4Cyclin-dependent kinase 22.7.11.220.454
2vu3LZECyclin-dependent kinase 22.7.11.220.454
3ddpRC8Cyclin-dependent kinase 22.7.11.220.454
3vspEK8Peroxisome proliferator-activated receptor gamma/0.454
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.454
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.454
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.454
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.454
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.454
5av2KMPDeath-associated protein kinase 12.7.11.10.454
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.453
2pvlP55Casein kinase II subunit alpha2.7.11.10.453
2zdu446Mitogen-activated protein kinase 102.7.11.240.453
3bheBZNGag-Pol polyprotein3.4.23.160.453
3rak03ZCyclin-dependent kinase 22.7.11.220.453
3vt9YI4Vitamin D3 receptor/0.453
4fkv61KCyclin-dependent kinase 22.7.11.220.453
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.453
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.453
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.453
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.452
2q5g1FAPeroxisome proliferator-activated receptor delta/0.452
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.452
2zjwREFCasein kinase II subunit alpha2.7.11.10.452
3a62STURibosomal protein S6 kinase beta-12.7.11.10.452
3dogNNNCyclin-dependent kinase 22.7.11.220.452
3ggxGGXGag-Pol polyprotein/0.452
3qqhX0ACyclin-dependent kinase 22.7.11.220.452
3qtxX43Cyclin-dependent kinase 22.7.11.220.452
3r7uX96Cyclin-dependent kinase 22.7.11.220.452
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.452
4bgh3I6Cyclin-dependent kinase 22.7.11.220.452
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.452
4iva1J5Tyrosine-protein kinase JAK2/0.452
4j99ACPFibroblast growth factor receptor 2/0.452
4jboWPHAurora kinase A2.7.11.10.452
4ysjADPCalmodulin-like domain protein kinase/0.452
5dnrATPAurora kinase A2.7.11.10.452
5e8wSTUTGF-beta receptor type-12.7.11.300.452
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1vikBAYGag-Pol polyprotein/0.451
1w8cN69Cyclin-dependent kinase 22.7.11.220.451
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.451
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.451
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.451
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.451
3gxlQIGTGF-beta receptor type-12.7.11.300.451
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.451
3oom507Activin receptor type-12.7.11.300.451
4anmWULCasein kinase II subunit alpha2.7.11.10.451
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.451
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.451
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.451
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.451
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
5dt3ATPAurora kinase A2.7.11.10.451
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
1kkq471Peroxisome proliferator-activated receptor alpha/0.450
1rfvADPPyridoxal kinase2.7.1.350.450
1xe55FEPlasmepsin-23.4.23.390.450
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.450
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.450
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.450
3fhyATPPyridoxal kinase2.7.1.350.450
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3pgqGY3Acetyl-CoA carboxylase/0.450
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.450
3vcyUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.450
4e4m0NHTyrosine-protein kinase JAK2/0.450
1ppm0P1Penicillopepsin-13.4.23.200.449
1u4dDBQActivated CDC42 kinase 1/0.449
2f81017Gag-Pol polyprotein3.4.23.160.449
2gjlFMNNitronate monooxygenase1.13.12.160.449
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.449
3c4zADPRhodopsin kinase/0.449
3cyxROCGag-Pol polyprotein3.4.23.160.449
3r9oZ71Cyclin-dependent kinase 22.7.11.220.449
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.449
3tqhNDPQuinone oxidoreductase/0.449
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.449
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.449
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.449
4lyn1YGCyclin-dependent kinase 22.7.11.220.449
4ww0ADPATP-dependent zinc metalloprotease FtsH/0.449
4yryFADGlutamate synthase, beta subunit/0.449
1dr3TAPDihydrofolate reductase1.5.1.30.448
1h7wFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.20.448
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1pxmCK5Cyclin-dependent kinase 22.7.11.220.448
1pyePM1Cyclin-dependent kinase 22.7.11.220.448
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.448
2p3b3TLV-1 PROTEASE protein/0.448
2p3b3TLV-1 protease/0.448
2uzeC95Cyclin-dependent kinase 22.7.11.220.448
2w1hL0FCyclin-dependent kinase 22.7.11.220.448
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.448
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.448
3rk909ZCyclin-dependent kinase 22.7.11.220.448
3w551FMMitogen-activated protein kinase 12.7.11.240.448
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.448
4ful0VUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4fv4EK7Mitogen-activated protein kinase 12.7.11.240.448
4jbqVX6Aurora kinase A2.7.11.10.448
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1pxpCK8Cyclin-dependent kinase 22.7.11.220.447
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.447
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.447
2j0lANPFocal adhesion kinase 12.7.10.20.447
2v7a627Tyrosine-protein kinase ABL12.7.10.20.447
2w05FRTCyclin-dependent kinase 22.7.11.220.447
2xj2985Serine/threonine-protein kinase pim-12.7.11.10.447
3qxpX64Cyclin-dependent kinase 22.7.11.220.447
3r1qX75Cyclin-dependent kinase 22.7.11.220.447
3unk0BYCyclin-dependent kinase 22.7.11.220.447
3wagTYDGlycosyltransferase/0.447
3wblPDYCyclin-dependent kinase 22.7.11.220.447
4fkr45KCyclin-dependent kinase 22.7.11.220.447
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.447
4qgiROCGag-Pol polyprotein3.4.23.160.447
4w9wYDJBMP-2-inducible protein kinase2.7.11.10.447
1hckATPCyclin-dependent kinase 22.7.11.220.446
1y0s331Peroxisome proliferator-activated receptor delta/0.446
2bheBRYCyclin-dependent kinase 22.7.11.220.446
2r3iSCFCyclin-dependent kinase 22.7.11.220.446
2r3lSCWCyclin-dependent kinase 22.7.11.220.446
2w4jADPDeath-associated protein kinase 12.7.11.10.446
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.446
2zoq5IDMitogen-activated protein kinase 32.7.11.240.446
3at4CCKCasein kinase II subunit alpha2.7.11.10.446
3cs8BRLPeroxisome proliferator-activated receptor gamma/0.446
3eyhIZATyrosine-protein kinase JAK1/0.446
3qu0X40Cyclin-dependent kinase 22.7.11.220.446
3u33FADPutative acyl-CoA dehydrogenase AidB1.3.990.446
3uyt0CKCasein kinase I isoform delta2.7.11.10.446
4a6cQG9Gag-Pol polyprotein3.4.23.160.446
4jqeANPCasein kinase II subunit alpha2.7.11.10.446
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.446
4ryvZEAProtein LlR18A/0.446
4y95746Tyrosine-protein kinase/0.446
1fvv107Cyclin-dependent kinase 22.7.11.220.445
1gih1PUCyclin-dependent kinase 22.7.11.220.445
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.445
1om1IQACasein kinase II subunit alpha2.7.11.10.445
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.445
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.445
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.445
2b1pAIZMitogen-activated protein kinase 102.7.11.240.445
2c6kDT2Cyclin-dependent kinase 22.7.11.220.445
2i0zFADNAD(FAD)-utilizing dehydrogenases/0.445
3c4wATPRhodopsin kinase/0.445
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.445
3ddqRRCCyclin-dependent kinase 22.7.11.220.445
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.20.445
4eos1ROCyclin-dependent kinase 22.7.11.220.445
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.445
4g3e0WCMitogen-activated protein kinase kinase kinase 142.7.11.250.445
4hvi19STyrosine-protein kinase JAK32.7.10.20.445
4jbiNDPAlcohol dehydrogenase (Zinc)/0.445
4qi4FADCellobiose dehydrogenase/0.445
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.445
1m2rMNYCasein kinase II subunit alpha2.7.11.10.444
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.444
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.444
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.444
2dwbANPAurora kinase A2.7.11.10.444
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.444
2pwlACPFibroblast growth factor receptor 2/0.444
2wotZZGTGF-beta receptor type-12.7.11.300.444
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.444
3efwAK8Aurora kinase A2.7.11.10.444
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.444
3iupNDPPossible NADH oxidoreductase/0.444
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.444
3r73X87Cyclin-dependent kinase 22.7.11.220.444
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4dgmAGICasein kinase II subunit alpha2.7.11.10.444
4e1z0MXNon-receptor tyrosine-protein kinase TYK22.7.10.20.444
4fob0USALK tyrosine kinase receptor2.7.10.10.444
4k771Q4Tyrosine-protein kinase JAK1/0.444
4xumIMNPeroxisome proliferator-activated receptor gamma/0.444
5dr2ATPAurora kinase A2.7.11.10.444
1k6cMK1Gag-Pol polyprotein3.4.23.160.443
1o97FADElectron transfer flavoprotein subunit alpha/0.443
1yonA2R2-dehydropantoate 2-reductase1.1.1.1690.443
2iw94SPCyclin-dependent kinase 22.7.11.220.443
2izrBRKCasein kinase I isoform gamma-32.7.11.10.443
2pmlANPUncharacterized protein/0.443
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.443
3hwrNDP2-dehydropantoate 2-reductase/0.443
3m9vTYDFAD-dependent oxidoreductase/0.443
3s2pPMUCyclin-dependent kinase 22.7.11.220.443
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.443
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.443
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.443
4ivc1J6Tyrosine-protein kinase JAK1/0.443
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.443
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.442
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.442
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.442
2ds11CDCyclin-dependent kinase 22.7.11.220.442
2np8CC3Aurora kinase A2.7.11.10.442
2pvhP19Casein kinase II subunit alpha2.7.11.10.442
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.442
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.442
2yaaATPDeath-associated protein kinase 2/0.442
3frqERYErythromycin resistance repressor protein/0.442
3lltANPProtein serine/threonine kinase-1/0.442
3oibFDAPutative acyl-CoA dehydrogenase/0.442
3pdqKC6Lysine-specific demethylase 4A1.14.110.442
3qx4X4BCyclin-dependent kinase 22.7.11.220.442
3qyw6PBMitogen-activated protein kinase 12.7.11.240.442
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.442
4djy0KRBeta-secretase 13.4.23.460.442
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4ki8ADP60 kDa chaperonin/0.442
4nbwNADShort-chain dehydrogenase/reductase SDR/0.442
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.442
5cvhADPCasein kinase II subunit alpha2.7.11.10.442
1jioDEB6-deoxyerythronolide B hydroxylase/0.441
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.441
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.441
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.441
1pxoCK7Cyclin-dependent kinase 22.7.11.220.441
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.441
1xe65FPPlasmepsin-23.4.23.390.441
1xjdSTUProtein kinase C theta type2.7.11.130.441
1xl2189Gag-Pol polyprotein3.4.23.160.441
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.441
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.441
2wtjWTJSerine/threonine-protein kinase Chk22.7.11.10.441
3bc3OPTCathepsin L13.4.22.150.441
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3qtzX42Cyclin-dependent kinase 22.7.11.220.441
3qzgX67Cyclin-dependent kinase 22.7.11.220.441
3rahO1ZCyclin-dependent kinase 22.7.11.220.441
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.441
4g6oE28Mitogen-activated protein kinase 12.7.11.240.441
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.441
4o0wADNAurora kinase A2.7.11.10.441
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.441
1a2nTETUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.440
1hiiC20Gag-Pol polyprotein/0.440
1oguST8Cyclin-dependent kinase 22.7.11.220.440
1pr9NAPL-xylulose reductase1.1.1.100.440
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
1zhwHC2Oxysterol-binding protein homolog 4/0.440
2a5uQYTPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
2nnkROCProtease/0.440
2q641UNGag-Pol polyprotein3.4.23.160.440
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.440
2xuuADPDeath-associated protein kinase 12.7.11.10.440
3b6zCO7Enoyl reductase LovC10.440
3l0lHC3Nuclear receptor ROR-gamma/0.440
3lpkZ76Beta-secretase 13.4.23.460.440
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.440
3oev3OEProteasome subunit beta type-53.4.25.10.440
3oev3OEProteasome subunit beta type-63.4.25.10.440
3orpAGSSerine/threonine protein kinase/0.440
3so9017Pol protein/0.440
4b8zNAPGDP-L-fucose synthase1.1.1.2710.440
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.440
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.440
4gk3L87Ephrin type-A receptor 32.7.10.10.440
4gub0Y4Casein kinase II subunit alpha2.7.11.10.440
4i8zG08Gag-Pol polyprotein3.4.23.160.440
4ji91M3Tyrosine-protein kinase JAK2/0.440
4kb81QOCasein kinase I isoform delta2.7.11.10.440
4lopSB4Mitogen-activated protein kinase 14/0.440
4o0uADNAurora kinase A2.7.11.10.440
5c41ACPRibokinase/0.440
5jscFADPutative acyl-CoA dehydrogenase/0.440