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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2z1xPRFQueuine tRNA-ribosyltransferase2.4.2.29

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2z1xPRFQueuine tRNA-ribosyltransferase2.4.2.291.000
1q63AIQQueuine tRNA-ribosyltransferase2.4.2.290.701
3ge7AFQQueuine tRNA-ribosyltransferase2.4.2.290.696
1y5wNEZQueuine tRNA-ribosyltransferase2.4.2.290.695
4gh10WXQueuine tRNA-ribosyltransferase2.4.2.290.690
4fsa0V3Queuine tRNA-ribosyltransferase2.4.2.290.680
2bbf344Queuine tRNA-ribosyltransferase2.4.2.290.679
3sm0AEKQueuine tRNA-ribosyltransferase2.4.2.290.673
4gh30EVQueuine tRNA-ribosyltransferase2.4.2.290.666
3gc4AAQQueuine tRNA-ribosyltransferase2.4.2.290.661
1efzPRFQueuine tRNA-ribosyltransferase2.4.2.290.657
4fps0UXQueuine tRNA-ribosyltransferase2.4.2.290.655
4gkt0O1Queuine tRNA-ribosyltransferase2.4.2.290.652
1q4wDQUQueuine tRNA-ribosyltransferase2.4.2.290.646
3gc52MQQueuine tRNA-ribosyltransferase2.4.2.290.639
4gcxPRFQueuine tRNA-ribosyltransferase2.4.2.290.639
4gi40EXQueuine tRNA-ribosyltransferase2.4.2.290.639
1y5xE89Queuine tRNA-ribosyltransferase2.4.2.290.615
1r5yDQUQueuine tRNA-ribosyltransferase2.4.2.290.611
4fr10V2Queuine tRNA-ribosyltransferase2.4.2.290.605
4giy0WYQueuine tRNA-ribosyltransferase2.4.2.290.605
4gg90WWQueuine tRNA-ribosyltransferase2.4.2.290.604
1k4hAPQQueuine tRNA-ribosyltransferase2.4.2.290.600
1ozqPRFQueuine tRNA-ribosyltransferase2.4.2.290.600
2qzrS79Queuine tRNA-ribosyltransferase2.4.2.290.592
4hvxQEIQueuine tRNA-ribosyltransferase2.4.2.290.590
1p0ePRFQueuine tRNA-ribosyltransferase2.4.2.290.586
4hqvQEIQueuine tRNA-ribosyltransferase2.4.2.290.576
2z1wBDIQueuine tRNA-ribosyltransferase2.4.2.290.569
1k4gAIQQueuine tRNA-ribosyltransferase2.4.2.290.567
1f3eDPZQueuine tRNA-ribosyltransferase2.4.2.290.561
4hshQEIQueuine tRNA-ribosyltransferase2.4.2.290.554
1q65BHBQueuine tRNA-ribosyltransferase2.4.2.290.549
1q66KMBQueuine tRNA-ribosyltransferase2.4.2.290.540
1pxgPRFQueuine tRNA-ribosyltransferase2.4.2.290.534
3bllBPQQueuine tRNA-ribosyltransferase2.4.2.290.531
1ao8MTXDihydrofolate reductase1.5.1.30.520
3bldPRFQueuine tRNA-ribosyltransferase2.4.2.290.519
2potGUNQueuine tRNA-ribosyltransferase2.4.2.290.516
4s1iPLPPyridoxal kinase, putative/0.514
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.511
1vrqFONSubunit alpha of sarocosine oxidase/0.511
1gky5GPGuanylate kinase2.7.4.80.510
3sl2ATPSensor histidine kinase WalK/0.509
1mrqSTRAldo-keto reductase family 1 member C1/0.505
3axsSFGtRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase/0.505
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.504
2p0aANPSynapsin-3/0.502
3bloQEIQueuine tRNA-ribosyltransferase2.4.2.290.501
3oafOAGDihydrofolate reductase1.5.1.30.501
4bwaN0BPyrrolysine--tRNA ligase/0.500
1fw0KAIGlutamate receptor 2/0.499
4r5wXAVPoly [ADP-ribose] polymerase 12.4.2.300.499
1yhjR6CPyridoxal kinase2.7.1.350.498
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.498
1jf0CZHObelin/0.495
1rc4DDFDihydrofolate reductase1.5.1.30.495
3dgeADPSensor histidine kinase/0.495
4q8pCKRQueuine tRNA-ribosyltransferase2.4.2.290.495
4iarERM5-hydroxytryptamine receptor 1B/0.494
4l64C2F5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase2.1.1.140.494
4da6GA2Purine nucleoside phosphorylase DeoD-type2.4.2.10.493
1ez0NAPNADP-dependent fatty aldehyde dehydrogenase1.2.1.40.492
3znrNU9Histone deacetylase 73.5.1.980.492
4ej1FOLDihydrofolate reductase1.5.1.30.492
4jva1ORcAMP-dependent protein kinase type II-beta regulatory subunit/0.490
3biz61EWee1-like protein kinase2.7.10.20.489
3s41S41Glucokinase2.7.1.20.489
4nqgCZHMitrocomin/0.488
2w9hTOPDihydrofolate reductase1.5.1.30.487
4kttSAMS-adenosylmethionine synthase isoform type-22.5.1.60.487
1rx8FOLDihydrofolate reductase1.5.1.30.486
3axtSAMtRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase/0.485
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.485
3w3zGTPGTP-binding nuclear protein Ran/0.485
1xddAAYIntegrin alpha-L/0.484
4ajgF07cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.484
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.484
1cqp803Integrin alpha-L/0.483
1dliUDXUDP-glucose 6-dehydrogenase/0.483
1h2bNAJNAD-dependent alcohol dehydrogenase/0.483
1ove358Mitogen-activated protein kinase 14/0.483
4qjcIXEDihydrofolate reductase1.5.1.30.483
1ex75GPGuanylate kinase2.7.4.80.482
3n76CA23-dehydroquinate dehydratase4.2.1.100.482
1el4CTZObelin/0.481
2x9vTMQPteridine reductase/0.481
1yqj6NPMitogen-activated protein kinase 14/0.480
4kfj1R0Dihydrofolate reductase1.5.1.30.480
1ay0TPPTransketolase 12.2.1.10.479
1ej3CZHAequorin-2/0.479
2vbvFMNRiboflavin kinase2.7.1.1610.479
2blcCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.478
2mokFMNFlavodoxin 1/0.478
2zthSAMCatechol O-methyltransferase2.1.1.60.478
3gncQQQGlutaryl-CoA dehydrogenase/0.478
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.477
2nnqT4BFatty acid-binding protein, adipocyte/0.477
4ndnSAMS-adenosylmethionine synthase isoform type-22.5.1.60.477
4tx9AMZPhosphoribosyl isomerase A/0.477
1x2hLPALipoate-protein ligase A6.3.1.200.476
3cr0809Wee1-like protein kinase2.7.10.20.476
3sglSAMtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC/0.476
4b6uM7GEukaryotic translation initiation factor 4E type 3/0.476
4d79ATPtRNA threonylcarbamoyladenosine dehydratase6.10.476
1xp6AIUEstrogen receptor/0.475
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.475
1s3uTQDDihydrofolate reductase1.5.1.30.474
3eon341Glutaryl-CoA dehydrogenase/0.474
3znsNU7Histone deacetylase 73.5.1.980.474
4h7zGUNQueuine tRNA-ribosyltransferase2.4.2.290.474
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.474
1kruIPTGalactoside O-acetyltransferase2.3.1.180.473
1pr0NOSPurine nucleoside phosphorylase DeoD-type/0.473
1rx7FOLDihydrofolate reductase1.5.1.30.473
1vbiNADMalate/L-lactate dehydrogenase family protein/0.473
2io6330Wee1-like protein kinase2.7.10.20.473
3fhxPLPPyridoxal kinase2.7.1.350.473
4imfSI3N-acetylneuraminate lyase/0.473
4l1xSTRAldo-keto reductase family 1 member C2/0.473
4q4eBB2Aminopeptidase N3.4.11.20.473
3nxyD2HDihydrofolate reductase1.5.1.30.472
4b1e6T6Beta-secretase 13.4.23.460.472
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.472
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.472
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.471
1jf2CZHObelin/0.471
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.471
1xduSFGAclacinomycin 10-hydroxylase RdmB4.1.10.471
3arvSAUChitinase A/0.471
3g72A6TRenin3.4.23.150.471
1rx4DDFDihydrofolate reductase1.5.1.30.470
2dxeGDPNucleoside diphosphate kinase2.7.4.60.470
2olcADPMethylthioribose kinase2.7.1.1000.470
3bl7DD1m7GpppX diphosphatase3.6.1.590.470
3eanNAPThioredoxin reductase 1, cytoplasmic1.8.1.90.470
3iktNADRedox-sensing transcriptional repressor Rex/0.470
4dhyS41Glucokinase2.7.1.20.470
4i13FOLDihydrofolate reductase1.5.1.30.470
3sn6P0GBeta-2 adrenergic receptor/0.470
1qv1CZHObelin/0.469
3ex8AIFRiboflavin biosynthesis protein RibD1.1.1.1930.469
3hwxTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.469
3q2jCKIAminoglycoside 3'-phosphotransferase2.7.1.950.469
1npdNADQuinate/shikimate dehydrogenase/0.468
1qv0CZHObelin/0.468
2z2w770Wee1-like protein kinase2.7.10.20.468
3l2kPXCEhpF/0.468
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.468
4iilRBFMembrane lipoprotein TpN38(b)/0.468
1nbhSAMGlycine N-methyltransferase2.1.1.200.467
2bakAQZMitogen-activated protein kinase 14/0.467
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.467
4a9yAQZMitogen-activated protein kinase 14/0.467
4du6GTPGTP cyclohydrolase 1/0.467
4i8vBHFCytochrome P450 1A11.14.14.10.467
4m2xTMQDihydrofolate reductase1.5.1.30.467
1dr4HBIDihydrofolate reductase1.5.1.30.466
1r00SAHAclacinomycin 10-hydroxylase RdmB4.1.10.466
1rx6DDFDihydrofolate reductase1.5.1.30.466
2wjoQUDBeta-secretase 13.4.23.460.466
2zi63D1Deoxycytidine kinase2.7.1.740.466
3bi6396Wee1-like protein kinase2.7.10.20.466
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.466
4azwATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.466
4l0t1V0Tankyrase-22.4.2.300.466
4x81MVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.466
5dn1AMZPhosphoribosyl isomerase A5.3.1.160.466
1q1gMTIPurine nucleoside phosphorylase/0.465
1u1d181Uridine phosphorylase2.4.2.30.465
2dy9ADPNucleoside diphosphate kinase2.7.4.60.465
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
4fgcPQ0NADPH-dependent 7-cyano-7-deazaguanine reductase1.7.1.130.465
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
4pkwGM6Lethal factor3.4.24.830.465
1a9cGTPGTP cyclohydrolase 13.5.4.160.464
1gpuTHDTransketolase 12.2.1.10.464
3fr5I4AFatty acid-binding protein, adipocyte/0.464
3nxrD2DDihydrofolate reductase1.5.1.30.464
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.464
4au7SAHHistone-lysine N-methyltransferase KMT5C2.1.1.430.464
4f3gKAIGlutamate receptor 3/0.464
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.464
4x7uZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.464
2in6839Wee1-like protein kinase2.7.10.20.463
2w5bAGSSerine/threonine-protein kinase Nek22.7.11.10.463
2wn6NDPADP-ribosyltransferase enzymatic component/0.463
3q2mCKISpectinomycin phosphotransferase/0.463
4da7AC2Purine nucleoside phosphorylase DeoD-type2.4.2.10.463
4gkh0J9Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.463
4h03NADIota toxin component Ia/0.463
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.463
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.463
5cccDDFDihydrofolate reductase1.5.1.30.463
1pr4MTPPurine nucleoside phosphorylase DeoD-type/0.462
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.462
2x7jTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.462
3g70A5TRenin3.4.23.150.462
3x025GPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.462
4bdrKAIGlutamate receptor ionotropic, kainate 2/0.462
4bvnP32Beta-1 adrenergic receptor/0.462
4eb5PLPCysteine desulfurase IscS 2/0.462
4f1yCNIGlutamate receptor 3/0.462
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.462
1gaxVAAValine--tRNA ligase6.1.1.90.461
3cgyRDCVirulence sensor histidine kinase PhoQ2.7.13.30.461
3cqeP91Wee1-like protein kinase2.7.10.20.461
3jq8DX3Pteridine reductase, putative/0.461
3pdqKC6Lysine-specific demethylase 4A1.14.110.461
4elb34SDihydrofolate reductase/0.461
4fhd0TTSpore photoproduct lyase/0.461
4i1nFOLDihydrofolate reductase1.5.1.30.461
4imgNGFN-acetylneuraminate lyase/0.461
4kc1WS1Histo-blood group ABO system transferase/0.461
4lutDCSAlanine racemase/0.461
5bp9SAHPutative methyltransferase protein/0.461
1lb9DNQGlutamate receptor 2/0.460
1lhwESMSex hormone-binding globulin/0.460
1mq0BRDCytidine deaminase3.5.4.50.460
2y035FWBeta-1 adrenergic receptor/0.460
3aw9GDUNAD-dependent epimerase/dehydratase/0.460
3c35KAIGlutamate receptor ionotropic, kainate 1/0.460
3c3dFO12-phospho-L-lactate transferase/0.460
3d5wADPSerine/threonine-protein kinase PLK/0.460
3exfTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.460
3exfTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.460
3v0m5GWHisto-blood group ABO system transferase/0.460
4buwF33Tankyrase-22.4.2.300.460
4fewPP2Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.460
4hlm16STankyrase-22.4.2.300.460
4x7wMVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.460
5hpyGDPTransforming protein RhoA/0.460
1ra8FOLDihydrofolate reductase1.5.1.30.459
1x1bSAHC-20 methyltransferase/0.459
2cbjOANO-GlcNAcase NagJ/0.459
2ovvPFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.459
2rd678PPoly [ADP-ribose] polymerase 12.4.2.300.459
3anmSYD1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.459
3n87N873-dehydroquinate dehydratase4.2.1.100.459
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
3ufl508Beta-secretase 13.4.23.460.459
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.459
4xe606UDihydrofolate reductase1.5.1.30.459
1u22THG5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 12.1.1.140.458
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
2azyCHDPhospholipase A2, major isoenzyme3.1.1.40.458
2b8jADNClass B acid phosphatase3.1.3.20.458
2dxfGNPNucleoside diphosphate kinase2.7.4.60.458
2hxzH7JCathepsin S3.4.22.270.458
2yqzSAMUncharacterized protein/0.458
3nxoD2BDihydrofolate reductase1.5.1.30.458
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.458
3vv8B02Beta-secretase 13.4.23.460.458
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.458
4l2g1V4Tankyrase-22.4.2.300.458
4n1fCZHObelin/0.458
4ol0GTPGTP-binding nuclear protein Ran/0.458
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.457
1lbbKAIGlutamate receptor 2/0.457
1pr6XYAPurine nucleoside phosphorylase DeoD-type/0.457
1xh4R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
2pl0STITyrosine-protein kinase Lck2.7.10.20.457
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.457
3bi2FADPolyamine oxidase FMS1/0.457
3i5xANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.457
3imxB84Glucokinase2.7.1.20.457
4ddrMMVDihydrofolate reductase1.5.1.30.457
4jeyPLPAcetylornithine/succinyldiaminopimelate aminotransferase2.6.1.110.457
1mp4UPGGlucose-1-phosphate thymidylyltransferase/0.456
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
2oalFADFlavin-dependent tryptophan halogenase RebH1.14.19.90.456
3rm8RM8Acidic mammalian chitinase3.2.1.140.456
3um81CYBifunctional dihydrofolate reductase-thymidylate synthase/0.456
4bueJQFTankyrase-22.4.2.300.456
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
4kotCE3Uncharacterized protein/0.456
4rrlA3SProbable threonine--tRNA ligase 26.1.1.30.456
1hfqMOTDihydrofolate reductase1.5.1.30.455
1mraAPGMandelate racemase/0.455
1sj0E4DEstrogen receptor/0.455
2cleF6FTryptophan synthase alpha chain/0.455
2qk8MTXDihydrofolate reductase/0.455
2y02WHJBeta-1 adrenergic receptor/0.455
2zzcNAPThioredoxin reductase 1, cytoplasmic1.8.1.90.455
3c36KAIGlutamate receptor ionotropic, kainate 1/0.455
3mcyZH1FimH/0.455
3qvwNADMyo-inositol-1-phosphate synthase (Ino1)/0.455
4a4xJUPSerine/threonine-protein kinase Nek22.7.11.10.455
4jauADPSensor histidine kinase/0.455
4s1b2BALmo1466 protein/0.455
4zqmXMPInosine-5'-monophosphate dehydrogenase/0.455
1bzfTMQDihydrofolate reductase1.5.1.30.454
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.454
1dljUGAUDP-glucose 6-dehydrogenase/0.454
1mxfMTXPutative pteridine reductase 2/0.454
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.454
1zy5ANPeIF-2-alpha kinase GCN2/0.454
2clmF6FTryptophan synthase alpha chain/0.454
2wksCB63-dehydroquinate dehydratase4.2.1.100.454
2zruFMNIsopentenyl-diphosphate delta-isomerase/0.454
3p8iFMNPentaerythritol tetranitrate reductase/0.454
3vqdMOKPOL polyprotein/0.454
4rphGDUUDP-galactopyranose mutase5.4.99.90.454
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.454
5a8eXTKBeta-1 adrenergic receptor/0.454
1cjwCOTSerotonin N-acetyltransferase/0.453
1f8gNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.453
1l8aTDPPyruvate dehydrogenase E1 component1.2.4.10.453
1ni4TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.453
1ni4TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.453
1rftPXMPyridoxal kinase2.7.1.350.453
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.453
2p1t3TNRetinoic acid receptor RXR-alpha/0.453
3hucG97Mitogen-activated protein kinase 14/0.453
3uq9TBNPutative adenosine kinase/0.453
3vri1KXHLA class I histocompatibility antigen, B-57 alpha chain/0.453
4b6s2HN3-dehydroquinate dehydratase4.2.1.100.453
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.453
1e66HUXAcetylcholinesterase3.1.1.70.452
1mc1PCXCarboxyethyl-arginine beta-lactam-synthase6.3.3.40.452
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.452
1w1rZEACytokinin dehydrogenase 11.5.99.120.452
1x8b824Wee1-like protein kinase2.7.10.20.452
2ieaTDPPyruvate dehydrogenase E1 component1.2.4.10.452
2j9lATPH(+)/Cl(-) exchange transporter 5/0.452
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
2v59LZKBiotin carboxylase6.3.4.140.452
2xauADPPre-mRNA-splicing factor ATP-dependent RNA helicase PRP433.6.4.130.452
2ytzSAHtRNA (guanine(26)-N(2))-dimethyltransferase/0.452
3b5iSAHIndole-3-acetate O-methyltransferase 1/0.452
3fl8RARDihydrofolate reductase/0.452
3kr6UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.452
3lfzADPUncharacterized protein MJ1225/0.452
3v0n4GWHisto-blood group ABO system transferase/0.452
4a6eASEAcetylserotonin O-methyltransferase2.1.1.40.452
4bb2STRCorticosteroid-binding globulin/0.452
4bgbADPPredicted molecular chaperone distantly related to HSP70-fold metalloproteases/0.452
4da8BG2Purine nucleoside phosphorylase DeoD-type2.4.2.10.452
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.452
4n3r2GUTankyrase-12.4.2.300.452
3ny8JRZBeta-2 adrenergic receptor/0.452
1rx5DDFDihydrofolate reductase1.5.1.30.451
1x1cSAHC-20 methyltransferase/0.451
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
2a3bCFFEndochitinase B13.2.1.140.451
2b1z17MEstrogen receptor/0.451
2ejuSAHtRNA (guanine(26)-N(2))-dimethyltransferase/0.451
2wqoVGKSerine/threonine-protein kinase Nek22.7.11.10.451
2y53NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase/0.451
2ykcYKCHeat shock protein HSP 90-alpha/0.451
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
3ptzUDXUDP-glucose 6-dehydrogenase1.1.1.220.451
4elh53IDihydrofolate reductase/0.451
4ha6PXMPyridoxine 4-oxidase/0.451
4ku7PCGcGMP-dependent protein kinase 12.7.11.120.451
4u7wNDPMxaA/0.451
4v12POGMaoC like domain protein/0.451
4zvnFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.451
1kuxCA3Serotonin N-acetyltransferase/0.450
1kuyCOTSerotonin N-acetyltransferase/0.450
1trkTPPTransketolase 12.2.1.10.450
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
1z6tADPApoptotic protease-activating factor 1/0.450
2blbCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.450
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.450
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.450
2ojg19AMitogen-activated protein kinase 12.7.11.240.450
3rhqNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.450
3rsv3RSBeta-secretase 13.4.23.460.450
4b70WM9Beta-secretase 13.4.23.460.450
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
4cdmFO1Deoxyribodipyrimidine photolyase/0.450
4hmhF94Tankyrase-22.4.2.300.450
4nbl2J6Caspase-63.4.22.590.450
4qoeFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.450
2yczI32Beta-1 adrenergic receptor/0.450
5f8uP32Beta-1 adrenergic receptor/0.450
1dnpMHFDeoxyribodipyrimidine photo-lyase4.1.99.30.449
1t57FMNConserved protein/0.449
1w29TS06,7-dimethyl-8-ribityllumazine synthase2.5.1.780.449
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.449
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
2yhuWHFPteridine reductase/0.449
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.449
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.449
3g5qFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.449
3gb4D3MDdmC/0.449
3nmhPYVAbscisic acid receptor PYL2/0.449
3qj0QI3Botulinum neurotoxin type A3.4.24.690.449
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.449
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
4buxF35Tankyrase-22.4.2.300.449
4cd2FOLDihydrofolate reductase1.5.1.30.449
4f31KAIGlutamate receptor 3/0.449
4hlh20DTankyrase-22.4.2.300.449
4p5fAR6Inosine-uridine nucleoside N-ribohydrolase/0.449
4yal2AMNADPH--cytochrome P450 reductase/0.449
5fe112QHistone acetyltransferase KAT2B2.3.1.480.449
3nyaJTZBeta-2 adrenergic receptor/0.449
1gj5130Prothrombin3.4.21.50.448
1hfpMOTDihydrofolate reductase1.5.1.30.448
1ia3TQ5Dihydrofolate reductase1.5.1.30.448
1mczRMNBenzoylformate decarboxylase4.1.1.70.448
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.448
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.448
1ulbGUNPurine nucleoside phosphorylase2.4.2.10.448
1z0dGDPRas-related protein Rab-5C/0.448
2c2aADPSensor histidine kinase/0.448
2gouFMNNADH:flavin oxidoreductase Sye1/0.448
2zwaSAHtRNA wybutosine-synthesizing protein 42.1.1.2900.448
3eigMTXDihydrofolate reductase1.5.1.30.448
3fknFKNMitogen-activated protein kinase 14/0.448
3new3NEMitogen-activated protein kinase 14/0.448
3nytULPUDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.448
3q44D50M1 family aminopeptidase3.4.110.448
3wyfGTPGTP-binding nuclear protein/0.448
4f1oACPProbable serine/threonine-protein kinase roco42.7.11.10.448
4iq71G9Mycocyclosin synthase1.14.21.90.448
4x7vMIVMycinamicin III 3''-O-methyltransferase2.1.1.2370.448
1hvyD16Thymidylate synthase2.1.1.450.447
1xtsGTPGTP-binding protein Rheb/0.447
2a9z26AAdenosine kinase2.7.1.200.447
2ejzSAHDiphthine synthase/0.447
2hveADPNucleoside diphosphate kinase A2.7.4.60.447
2ji9TPWOxalyl-CoA decarboxylase4.1.1.80.447
2wugHPK4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.447
2xtbKRMAdenosine kinase, putative/0.447
2zymACXPeriplasmic binding protein/0.447
3bj8COADiamine acetyltransferase 1/0.447
3eah327Nitric oxide synthase, endothelial1.14.13.390.447
3gluLYS_VAL_METNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.447
3hv3R49Mitogen-activated protein kinase 14/0.447
3o73O73Ribosyldihydronicotinamide dehydrogenase [quinone]/0.447
3of3DIHPurine nucleoside phosphorylase DeoD-type 1/0.447
3sxjSAMPutative methyltransferase/0.447
4iji99TGlutathione S-transferase-like protein YibF/0.447
1n3sGTPGTP cyclohydrolase 13.5.4.160.446
1nd52BFProstatic acid phosphatase3.1.3.20.446
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
1rgsCMPcAMP-dependent protein kinase type I-alpha regulatory subunit/0.446
1uhjCZBAequorin-2/0.446
1w1wAGSStructural maintenance of chromosomes protein 1/0.446
1zydATPeIF-2-alpha kinase GCN2/0.446
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.446
2ed3SAHDiphthine synthase/0.446
2wgeTLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.446
3fpbATPSarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.446
3m3z3F5Heat shock cognate 71 kDa protein/0.446
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.446
3ntrNADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase1.1.1.180.446
3p2kSAM16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.446
3rabGNPRas-related protein Rab-3A/0.446
3roeTHMNAD(P)H-hydrate epimerase5.1.99.60.446
4h0yNADIota toxin component Ia/0.446
4iah1DXAlr2278 protein/0.446
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.446
4omaLCSMethionine gamma-lyase/0.446
4rdiATPtRNA threonylcarbamoyladenosine dehydratase6.10.446
4rr8A3SProbable threonine--tRNA ligase 26.1.1.30.446
5epeSAHUncharacterized protein/0.446
1uxuNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.445
1ygkRRCPyridoxal kinase2.7.1.350.445
2c42TPPPyruvate synthase/0.445
2f2sCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.445
2pidYSATyrosine--tRNA ligase, mitochondrial6.1.1.10.445
2vi5Y196,7-dimethyl-8-ribityllumazine synthase2.5.1.780.445
2xnmWGZSerine/threonine-protein kinase Nek22.7.11.10.445
3c9tTPSThiamine-monophosphate kinase/0.445
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.445
3lpfZ77Beta-glucuronidase3.2.1.310.445
3qizQI2Botulinum neurotoxin type A3.4.24.690.445
3s8pSAMHistone-lysine N-methyltransferase KMT5B2.1.1.430.445
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.445
3wtiCT4Acetylcholine-binding protein/0.445
3zovWZVBeta-secretase 13.4.23.460.445
4kd79DRDihydrofolate reductase1.5.1.30.445
4khnXG4DNA-directed DNA polymerase/0.445
4lm4JPZcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
4o7uTHFThymidylate synthase/0.445
5dx1SFGHistone-arginine methyltransferase CARM1/0.445
3d4sTIMBeta-2 adrenergic receptor/0.445
1je1GMPPurine nucleoside phosphorylase/0.444
1kijNOVDNA gyrase subunit B/0.444
1ygjRMCPyridoxal kinase2.7.1.350.444
1z5uCMPClass B acid phosphatase/0.444
2a4xBLMMitomycin-binding protein/0.444
2xf3J01Uncharacterized protein/0.444
2xk730ESerine/threonine-protein kinase Nek22.7.11.10.444
3cow52HPantothenate synthetase6.3.2.10.444
3elePLPAminotransferase/0.444
3nxtD2EDihydrofolate reductase1.5.1.30.444
3nxvD2FDihydrofolate reductase1.5.1.30.444
3pce3HPProtocatechuate 3,4-dioxygenase alpha chain1.13.11.30.444
3pce3HPProtocatechuate 3,4-dioxygenase beta chain1.13.11.30.444
3pm1ETHTH-type transcriptional regulator QacR/0.444
4ele31IDihydrofolate reductase/0.444
4ivqI43Thymidine kinase/0.444
4lwbQJ8Nitric oxide synthase oxygenase1.14.13.1650.444
4uy6SAHHistidine N-alpha-methyltransferase/0.444
4yjdFADD-amino-acid oxidase1.4.3.30.444
5dbjFADFADH2-dependent halogenase PltA/0.444
1rdtL79Retinoic acid receptor RXR-alpha/0.443
1tkbN1TTransketolase 12.2.1.10.443
1u1jC2F5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 12.1.1.140.443
1xzqFONtRNA modification GTPase MnmE3.6.50.443
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.443
2i0v6C3Macrophage colony-stimulating factor 1 receptor2.7.10.10.443
2j7cIDEBeta-glucosidase A3.2.1.210.443
2rc6FADFerredoxin--NADP reductase/0.443
2v58LZJBiotin carboxylase6.3.4.140.443
2xdaJPS3-dehydroquinate dehydratase4.2.1.100.443
2yp0OVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.443
3d73NBBPheromone-binding protein ASP1/0.443
3hziATPSerine/threonine-protein kinase toxin HipA/0.443
3i53SAH2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase/0.443
3lq4TDPPyruvate dehydrogenase E1 component1.2.4.10.443
3nwe662Catechol O-methyltransferase2.1.1.60.443
3udj092Beta-secretase 13.4.23.460.443
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.443
4gusFADLysine-specific histone demethylase 1B10.443
1d5cGDPGTPase (Rab6)/0.442
1gt5BZQOdorant-binding protein/0.442
1ivsVAAValine--tRNA ligase6.1.1.90.442
1j8uH4BPhenylalanine-4-hydroxylase1.14.16.10.442
1jdzFMBPurine nucleoside phosphorylase/0.442
1pr1FMBPurine nucleoside phosphorylase DeoD-type/0.442
1s3wTQTDihydrofolate reductase1.5.1.30.442
2a2xNA9Prothrombin3.4.21.50.442
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.442
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3fhxPXLPyridoxal kinase2.7.1.350.442
3rl45GPMetallophosphoesterase MPPED23.10.442
3wv9FEGHmd co-occurring protein HcgE/0.442
4bkjSTIEpithelial discoidin domain-containing receptor 12.7.10.10.442
4elg52JDihydrofolate reductase/0.442
4hfp15UProthrombin3.4.21.50.442
4hy6FJ1Heat shock protein HSP 90-alpha/0.442
4j6cSTRCytochrome P450 monooxygenase/0.442
4ktl1CQCytochrome P450/0.442
4lwxMU2Ribosome inactivating protein/0.442
4man1Y1Apoptosis regulator Bcl-2/0.442
4pnmNU1Tankyrase-22.4.2.300.442
4qzuRTLRetinol-binding protein 2/0.442
4u0sADPAdenosine monophosphate-protein transferase FICD2.7.7.n10.442
4xoiGTPTransforming protein RhoA/0.442
4yaf2AMNADPH--cytochrome P450 reductase/0.442
4ys0ADPProtein translocase subunit SecA/0.442
5ero210Fusicoccadiene synthase2.5.1.290.442
1bwkFMNNADPH dehydrogenase 11.6.99.10.441
1g60SAMModification methylase MboII2.1.1.720.441
1getNAPGlutathione reductase1.8.1.70.441
1h5tDAUGlucose-1-phosphate thymidylyltransferase 1/0.441
1mo8ATPSodium/potassium-transporting ATPase subunit alpha-13.6.3.90.441
1pd9CO4Dihydrofolate reductase1.5.1.30.441
1svhI08cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
1xrpPRO_LEU_GLY_GLYProline iminopeptidase3.4.11.50.441
2b82ADNClass B acid phosphatase3.1.3.20.441
2gbyBRNHTH-type transcriptional regulator QacR/0.441
2gmuPDGPutative pyridoxamine 5-phosphate-dependent dehydrase/0.441
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.441
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.441
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
2w6cBM4Acetylcholinesterase3.1.1.70.441
2ycwCAUBeta-1 adrenergic receptor/0.441
3ar612DSarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.441
3b3fSAHHistone-arginine methyltransferase CARM1/0.441
3clrFADElectron transfer flavoprotein subunit alpha/0.441
3dntATPSerine/threonine-protein kinase toxin HipA/0.441
3fzfATPHeat shock cognate 71 kDa protein/0.441
3gcq1BUMitogen-activated protein kinase 14/0.441
3rtnRTNBeta-secretase 13.4.23.460.441
3x0a5GPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.441
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.441
4c717RD3-oxoacyl-ACP synthase/0.441
4g8cC6LAlpha/beta hydrolase fold protein/0.441
4hneADPPhosphatidylinositol 4-kinase type 2-alpha/0.441
4i4z2NE1,4-dihydroxy-2-naphthoyl-CoA synthase/0.441
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.441
4l0s1UZTankyrase-22.4.2.300.441
4x5iFOLDihydrofolate reductase1.5.1.30.441
5gcnCOAHAT A1/0.441
3qakUKAAdenosine receptor A2a/0.441
1e96GTPRas-related C3 botulinum toxin substrate 1/0.440
1o5rFR9Adenosine deaminase3.5.4.40.440
1ohjCOPDihydrofolate reductase1.5.1.30.440
1rfqLARActin, alpha skeletal muscle/0.440
1umlFR4Adenosine deaminase3.5.4.40.440
1waj5GPDNA-directed DNA polymerase/0.440
2bfaCB3Pteridine reductase 11.5.1.330.440
2c9dPHR6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
2poqISDTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase1.3.1.200.440
2puiADPMethylthioribose kinase2.7.1.1000.440
3a7dFBNCatechol O-methyltransferase2.1.1.60.440
3ntaFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.440
3rimTPPTransketolase2.2.1.10.440
3srsM23Dihydrofolate reductase1.5.1.30.440
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
3zpqXF5Beta-1 adrenergic receptor/0.440
4bfxZVXPantothenate kinase2.7.1.330.440
4ixd1HVIntegrin alpha-L/0.440
5dtoSAHGenome polyprotein/0.440