sc-PDB

List of CHEMBLId :

This value allows a number of roughly comparable measures of half-maximal response concentration/potency/affinity to be compared on a negative logarithmic scale (e.g., an IC50 measurement of 1nM would have a pChEMBL value of 9).

Uniprot Annotation

Name:	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
ID:	PDE10_HUMAN
AC:	Q9Y233
Organism:	Homo sapiens
Reign:	Eukaryota
TaxID:	9606
EC Number:	3.1.4.17

---

Chains:

Chain Name:	Percentage of Residues within binding site
D	100 %

---

Ligand binding site composition:

B-Factor:	36.703
Number of residues:	18
Including
Standard Amino Acids:	17
Non Standard Amino Acids:	0
Water Molecules:	1
Cofactors:
Metals:

---

Cavity properties

Ligandability	Volume (Å3)
1.081	904.500

% Hydrophobic	% Polar
57.46	42.54
According to VolSite

HET Code:	F07
Formula:	C10H6N2S
Molecular weight:	186.233 g/mol
DrugBank ID:	-
Buried Surface Area:	53.45 %
Polar Surface area:	54.02 Å2

Number of
H-Bond Acceptors:	2
H-Bond Donors:	0
Rings:	3
Aromatic rings:	3
Anionic atoms:	0
Cationic atoms:	0
Rule of Five Violation:	0
Rotatable Bonds:	0

---

Mass center Coordinates

X	Y	Z
42.3575	-2.71954	18.6375

• 2D View
• 3D View