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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1zrdCMPcAMP-activated global transcriptional regulator CRP

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1zrdCMPcAMP-activated global transcriptional regulator CRP/1.000
4ft8CMPcAMP-activated global transcriptional regulator CRP/0.621
4hzfCMPcAMP-activated global transcriptional regulator CRP/0.606
4i01CMPcAMP-activated global transcriptional regulator CRP/0.606
3rpqCMPcAMP-activated global transcriptional regulator CRP/0.582
3qopCMPcAMP-activated global transcriptional regulator CRP/0.580
3rypCMPcAMP-activated global transcriptional regulator CRP/0.578
3rdiCMPcAMP-activated global transcriptional regulator CRP/0.576
3rouCMPcAMP-activated global transcriptional regulator CRP/0.575
4i0aCMPcAMP-activated global transcriptional regulator CRP/0.574
1i5zCMPcAMP-activated global transcriptional regulator CRP/0.572
2oz6CMPCyclic AMP receptor-like protein/0.569
4i0bCMPcAMP-activated global transcriptional regulator CRP/0.566
1zrcCMPcAMP-activated global transcriptional regulator CRP/0.563
4r8hSP1cAMP-activated global transcriptional regulator CRP/0.563
1i6xCMPcAMP-activated global transcriptional regulator CRP/0.561
3otfCMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4/0.557
3kccCMPcAMP-activated global transcriptional regulator CRP/0.556
4i09CMPcAMP-activated global transcriptional regulator CRP/0.553
1g6nCMPcAMP-activated global transcriptional regulator CRP/0.547
3n4mCMPcAMP-activated global transcriptional regulator CRP/0.545
1cgpCMPcAMP-activated global transcriptional regulator CRP/0.536
1ruoCMPcAMP-activated global transcriptional regulator CRP/0.535
2gzwCMPcAMP-activated global transcriptional regulator CRP/0.534
3cl1PCGCyclic nucleotide-gated potassium channel mll3241/0.530
3ryrCMPcAMP-activated global transcriptional regulator CRP/0.530
4hj6FMNLOV protein/0.515
1vp6CMPCyclic nucleotide-gated potassium channel mll3241/0.513
2cgpCMPcAMP-activated global transcriptional regulator CRP/0.513
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.503
2a94AP0L-lactate dehydrogenase1.1.1.270.501
4n9iPCGCatabolite expression activator/0.501
4i02CMPcAMP-activated global transcriptional regulator CRP/0.500
1w6hTITPlasmepsin-23.4.23.390.499
1orrNADCDP-paratose 2-epimerase/0.498
1q43CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2/0.498
3w8wFADPutative FAD-dependent oxygenase EncM/0.495
1yb5NAPQuinone oxidoreductase1.6.5.50.494
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.494
4hiaFMNLOV protein/0.494
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.491
4iah1DXAlr2278 protein/0.491
1o97FADElectron transfer flavoprotein subunit alpha/0.490
1xvaSAMGlycine N-methyltransferase2.1.1.200.490
1xe55FEPlasmepsin-23.4.23.390.486
3ohh3HHBeta-secretase 13.4.23.460.486
4k28NADShikimate dehydrogenase family protein/0.486
1q3ePCGPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2/0.485
2b53D23Cyclin-dependent kinase 22.7.11.220.485
2g1s4IGRenin3.4.23.150.485
4nfsNAJAlcohol dehydrogenase E chain1.1.1.10.484
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.483
1mjaCOAHistone acetyltransferase ESA1/0.482
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.482
1fy7COAHistone acetyltransferase ESA1/0.481
2vwhNAPGlucose 1-dehydrogenase/0.481
3u0zCMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1/0.481
2hutSAHDiphthine synthase/0.480
4d7tCMPUncharacterized protein/0.480
4l4xNDPAmphI/0.480
2e15SAHDiphthine synthase/0.479
3bpzCMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2/0.479
2g1o2IGRenin3.4.23.150.478
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
4oztP1AEcdysone receptor, putative/0.478
2hk9NAPShikimate dehydrogenase (NADP(+))/0.477
2k0gCMPCyclic nucleotide-gated potassium channel mll3241/0.477
3vob9PCCell division protein FtsZ/0.477
1h74ADPHomoserine kinase2.7.1.390.476
1me6IVSPlasmepsin-23.4.23.390.474
1p4aPCPPur operon repressor/0.474
2gjlFMNNitronate monooxygenase1.13.12.160.474
2w3bNDPDihydrofolate reductase1.5.1.30.474
4hbnCMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4/0.474
4hjoAQ4Epidermal growth factor receptor2.7.10.10.474
1mj9COAHistone acetyltransferase ESA1/0.473
1qrpHH0Pepsin A-43.4.23.10.473
2i5bADPPyridoxine kinase/0.473
2vwqNAPGlucose 1-dehydrogenase/0.473
3btsNADGalactose/lactose metabolism regulatory protein GAL80/0.473
3pe2E1BCasein kinase II subunit alpha2.7.11.10.473
3iw1ASDSteroid C26-monooxygenase1.14.13.1410.472
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.471
2eh2SAHDiphthine synthase/0.471
3toh079Gag-Pol polyprotein2.7.7.490.471
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.471
1tj0FADBifunctional protein PutA1.5.5.20.470
1vceSAHDiphthine synthase/0.470
2ed5SAHDiphthine synthase/0.470
2eh5SAHDiphthine synthase/0.470
4a8v2ANMajor pollen allergen Bet v 1-J/0.470
1hw5CMPcAMP-activated global transcriptional regulator CRP/0.469
1lf2R37Plasmepsin-23.4.23.390.469
1m0b0ZQGag-Pol polyprotein3.4.23.160.469
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.469
4z5wILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.469
1g4tFTPThiamine-phosphate synthase/0.468
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
2dv3SAHDiphthine synthase/0.468
4bfzZVZPantothenate kinase2.7.1.330.468
4eudCOASuccinyl-CoA:acetate CoA-transferase/0.468
4i8x6P3L-lactate dehydrogenase A chain1.1.1.270.468
4i8zG08Gag-Pol polyprotein3.4.23.160.468
4ji91M3Tyrosine-protein kinase JAK2/0.468
1f8sFADL-amino-acid oxidase1.4.3.20.467
1qorNDPQuinone oxidoreductase 1/0.467
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.467
1jpaANPEphrin type-B receptor 22.7.10.10.466
2ahrNAPPyrroline-5-carboxylate reductase/0.466
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.466
2ed3SAHDiphthine synthase/0.466
4dpi0N1Beta-secretase 13.4.23.460.466
1nzfUPGDNA beta-glucosyltransferase/0.465
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
3enkUPGUDP-glucose 4-epimerase/0.465
3orfNADDihydropteridine reductase1.5.1.340.465
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.465
1h73ANPHomoserine kinase2.7.1.390.464
1lquNDPNADPH-ferredoxin reductase FprA1.18.1.20.464
2e16SAHDiphthine synthase/0.464
2huqSAHDiphthine synthase/0.464
2p6iSAHDiphthine synthase/0.464
2pmoHMDProtein kinase 7/0.464
3em3478Gag-Pol polyprotein3.4.23.160.464
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.464
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.464
4iva1J5Tyrosine-protein kinase JAK2/0.464
1u8fNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.463
1yonA2R2-dehydropantoate 2-reductase1.1.1.1690.463
1zemNADXylitol dehydrogenase/0.463
1zrzBI1Protein kinase C iota type2.7.11.130.463
2a1tFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.463
2ooyATP5'-AMP-activated protein kinase subunit gamma/0.463
2vttLZDCyclin-dependent kinase 22.7.11.220.463
2zbaZBATrichothecene 3-O-acetyltransferase/0.463
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.463
3iaaTYDCalG2/0.463
4bb3KKAIsopenicillin N synthase1.21.3.10.463
4mv8ACPBiotin carboxylase6.3.4.140.463
5a3bAPRSIR2 family protein/0.463
5dp2NAPCurF/0.463
1fm4DXCMajor pollen allergen Bet v 1-L/0.462
1qf4RPDAdenylosuccinate synthetase/0.462
1x7dNADPutative ornithine cyclodeaminase/0.462
1zdwFLVPrenyltransferase/0.462
2en5SAHDiphthine synthase/0.462
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.462
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.462
3dv3MEKDual specificity mitogen-activated protein kinase kinase 12.7.12.20.462
3hx4ANPCalmodulin-domain protein kinase 1/0.462
3jv7NADSecondary alcohol dehydrogenase/0.462
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.462
4aqc88ATyrosine-protein kinase JAK2/0.462
4nbwNADShort-chain dehydrogenase/reductase SDR/0.462
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.462
5ftcADPTPR domain protein/0.462
1cbqRE9Cellular retinoic acid-binding protein 2/0.461
2pg0FADAcyl-CoA dehydrogenase/0.461
2vd0D27Hematopoietic prostaglandin D synthase/0.461
2xa4AZ5Tyrosine-protein kinase JAK2/0.461
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
3hl0NADMaleylacetate reductase/0.461
3vsxR32Renin3.4.23.150.461
4a83DXCMajor pollen allergen Bet v 1-A/0.461
4b1uLABActin, alpha skeletal muscle/0.461
4z875GPInosine-5'-monophosphate dehydrogenase/0.461
1psa0ZLPepsin A3.4.23.10.460
1t2cNAIL-lactate dehydrogenase1.1.1.270.460
1xh6R94cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
3e8nVRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.460
3qlrNDPDihydrofolate reductase1.5.1.30.460
3u11CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4/0.460
4ki8ADP60 kDa chaperonin/0.460
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.459
1f8fNADBenzyl alcohol dehydrogenase/0.459
1lf3EH5Plasmepsin-23.4.23.390.459
1x2hLPALipoate-protein ligase A6.3.1.200.459
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.459
2bpw1INGag-Pol polyprotein3.4.23.160.459
2e07SAHDiphthine synthase/0.459
2hr8SAHDiphthine synthase/0.459
2rc4ACOHistone acetyltransferase KAT6A/0.459
2vn0TDZCytochrome P450 2C8/0.459
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.459
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.459
4djaFAD(6-4) photolyase/0.459
4dpuAGSMevalonate diphosphate decarboxylase/0.459
4g95OAGDihydrofolate reductase1.5.1.30.459
1gqtACPRibokinase/0.458
1m17AQ4Epidermal growth factor receptor2.7.10.10.458
1pjcNADAlanine dehydrogenase/0.458
1xq6NAPUncharacterized protein At5g02240/0.458
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
2ek4SAHDiphthine synthase/0.458
2g78REACellular retinoic acid-binding protein 2/0.458
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.458
3a3gDLZLumazine protein/0.458
3br3ETHTH-type transcriptional regulator QacR/0.458
3h06VBPGlutamate receptor 2/0.458
3l8xN4DMitogen-activated protein kinase 14/0.458
3nsh957Beta-secretase 13.4.23.460.458
3oibFDAPutative acyl-CoA dehydrogenase/0.458
3wagTYDGlycosyltransferase/0.458
4eu9COASuccinyl-CoA:acetate CoA-transferase/0.458
4i0i957Beta-secretase 13.4.23.460.458
1aztGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.457
1orkATCTetracycline repressor protein class D/0.457
1rfvADPPyridoxal kinase2.7.1.350.457
2dxwSAHDiphthine synthase/0.457
2pchSAHDiphthine synthase/0.457
2q5g1FAPeroxisome proliferator-activated receptor delta/0.457
3l6jZ90Alr2278 protein/0.457
3uqdATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.457
4bfxZVXPantothenate kinase2.7.1.330.457
5cyoGDPSeptin-9/0.457
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.456
1g1aNADdTDP-glucose 4,6-dehydratase/0.456
2freFMNNAD(P)H-flavin oxidoreductase/0.456
2p6dSAHDiphthine synthase/0.456
2qo9ANPEphrin type-A receptor 32.7.10.10.456
2y3rTRKTamL/0.456
2yq92AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.456
3ih0ANPUncharacterized sugar kinase PH14592.7.10.456
4c4oNADSADH/0.456
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.456
4jqh1MFAlr2278 protein/0.456
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.456
4y3jHICEndothiapepsin3.4.23.220.456
1bofGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.455
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.455
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
1lb9DNQGlutamate receptor 2/0.455
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.455
1rkxNADCDP-D-glucose-4,6-dehydratase/0.455
2emrSAHDiphthine synthase/0.455
2r43G3GGag-Pol polyprotein3.4.23.160.455
2wecPP5Penicillopepsin-13.4.23.200.455
3cukFADD-amino-acid oxidase1.4.3.30.455
3in6FMNUncharacterized protein/0.455
3lqfNADGalactitol dehydrogenase/0.455
4dfg0JVGag-Pol polyprotein3.4.23.160.455
4g7gVFVLanosterol 14-alpha-demethylase/0.455
4ienCOAPutative acyl-CoA hydrolase/0.455
4wjiNAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase/0.455
1lbcCYZGlutamate receptor 2/0.454
1p0hACOMycothiol acetyltransferase2.3.1.1890.454
1udaUFGUDP-glucose 4-epimerase5.1.3.20.454
1xddAAYIntegrin alpha-L/0.454
2bueCOAAAC(6')-Ib/0.454
2czfXMPOrotidine 5'-phosphate decarboxylase4.1.1.230.454
2ejjSAHDiphthine synthase/0.454
2g1r3IGRenin3.4.23.150.454
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.454
2v2zADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.454
3kb1ADPIron-sulfur cluster carrier protein/0.454
3p62FMNPentaerythritol tetranitrate reductase/0.454
3uylTYDProbable NDP-rhamnosyltransferase/0.454
3vt8YI3Vitamin D3 receptor/0.454
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.454
4hxyNDPPlm1/0.454
4m9aFDAAcyl-CoA dehydrogenase/0.454
5agaANPDNA polymerase theta/0.454
1e3eNAIAlcohol dehydrogenase 41.1.1.10.453
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.453
2eldSAHDiphthine synthase/0.453
2fzwNADAlcohol dehydrogenase class-31.1.1.10.453
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.453
2jb4A14Isopenicillin N synthase1.21.3.10.453
2p5fSAHDiphthine synthase/0.453
2y0mACOHistone acetyltransferase KAT8/0.453
3ac2KSETyrosine-protein kinase Lck2.7.10.20.453
3akzGSUGlutamate--tRNA ligase 2/0.453
3bnkFMNFlavoredoxin/0.453
3eldSFGMethyltransferase/0.453
3h03UBPGlutamate receptor 2/0.453
3ik6HCZGlutamate receptor 2/0.453
3oixFMNDihydroorotate dehydrogenase/0.453
3sw418KCyclin-dependent kinase 22.7.11.220.453
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.453
4jldADPAdenylate kinase/0.453
4m4922YL-lactate dehydrogenase A chain1.1.1.270.453
4m83ERYOleandomycin glycosyltransferase2.4.10.453
4ycoFMNtRNA-dihydrouridine(16) synthase/0.453
4yusFMNFamily 3 adenylate cyclase/0.453
1nhhANPDNA mismatch repair protein MutL/0.452
1qf5RPLAdenylosuccinate synthetase/0.452
1rneC60Renin3.4.23.150.452
2dxvSAHDiphthine synthase/0.452
2owkSAHDiphthine synthase/0.452
2pcmSAHDiphthine synthase/0.452
2rc3NADCBS domain/0.452
2rlcCHDCholoylglycine hydrolase3.5.1.240.452
3fhyATPPyridoxal kinase2.7.1.350.452
3h3sH15Collagen type IV alpha-3-binding protein/0.452
3uoyFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.452
3v2uATPProtein GAL3/0.452
3vyeVYERenin3.4.23.150.452
4ambDUDPutative glycosyl transferase/0.452
4ktc1X3Genome polyprotein3.4.21.980.452
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.452
5f8fSFGPossible transcriptional regulatory protein/0.452
1bwsNDPGDP-L-fucose synthase/0.451
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1qrrUPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.451
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.451
1x7gNAPPutative ketoacyl reductase1.3.10.451
2dc1NADProbable L-aspartate dehydrogenase/0.451
2ejzSAHDiphthine synthase/0.451
2emuSAHDiphthine synthase/0.451
2givACOHistone acetyltransferase KAT8/0.451
2ou2ACOHistone acetyltransferase KAT5/0.451
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
2y6o1N1Ephrin type-A receptor 42.7.10.10.451
3a6qFMNFMN-binding protein/0.451
3cltFADElectron transfer flavoprotein subunit alpha/0.451
3sqxANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.451
3t4nADP5'-AMP-activated protein kinase subunit gamma/0.451
3vswR31Renin3.4.23.150.451
4dpwAGSMevalonate diphosphate decarboxylase/0.451
4la1FADThioredoxin glutathione reductase/0.451
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.451
1b2lNDCAlcohol dehydrogenase1.1.1.10.450
1c3eNHRPhosphoribosylglycinamide formyltransferase/0.450
1h65GDPTranslocase of chloroplast 343.6.50.450
1rdwLARActin, alpha skeletal muscle/0.450
1vikBAYGag-Pol polyprotein/0.450
2eleSAHDiphthine synthase/0.450
2gv8NDPThiol-specific monooxygenase1.14.130.450
2huxSAHDiphthine synthase/0.450
2jk6FADTrypanothione reductase/0.450
2pwcG3GGag-Pol polyprotein3.4.23.160.450
2yeiXQIHeat shock protein HSP 90-alpha/0.450
2yr5FADPhenylalanine 2-monooxygenase precursor1.13.12.90.450
2znq401Peroxisome proliferator-activated receptor delta/0.450
3c16GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.450
3eljGS7Mitogen-activated protein kinase 82.7.11.240.450
3h3t16HCollagen type IV alpha-3-binding protein/0.450
3owaFADAcyl-CoA dehydrogenase/0.450
3qe0GDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.450
3s1dZIRCytokinin dehydrogenase 11.5.99.120.450
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.450
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.450
4a6nFADTetX family tetracycline inactivation enzyme/0.450
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
4dptAGSMevalonate diphosphate decarboxylase/0.450
4dxd9PCCell division protein FtsZ/0.450
4jia1K3Tyrosine-protein kinase JAK2/0.450
4jqlVJ6Heat shock protein HSP 90-alpha/0.450
4ks7X4ZSerine/threonine-protein kinase PAK 62.7.11.10.450
4m0f1YKAcetylcholinesterase3.1.1.70.450
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.450
2bbwGP5Adenylate kinase 4, mitochondrial/0.449
2dekSAHDiphthine synthase/0.449
2gtnLIEMitogen-activated protein kinase 14/0.449
2ojg19AMitogen-activated protein kinase 12.7.11.240.449
2wf4ZY4Beta-secretase 13.4.23.460.449
2xtnGTPGTPase IMAP family member 2/0.449
2z54AB1Gag-Pol polyprotein3.4.23.160.449
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3imgBZ2Pantothenate synthetase6.3.2.10.449
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.449
4ap3FADSteroid monooxygenase/0.449
4j95ACPFibroblast growth factor receptor 2/0.449
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.449
4u8iFDAUDP-galactopyranose mutase/0.449
4udrFAD5-(hydroxymethyl)furfural oxidase/0.449
4zlaBESCytosol aminopeptidase3.4.11.10.449
5jlaNADPutative short-chain dehydrogenase/reductase/0.449
1ezvUQ6Cytochrome b/0.448
1hbvGANGag-Pol polyprotein/0.448
1llwFMNFerredoxin-dependent glutamate synthase 21.4.7.10.448
1sbyNADAlcohol dehydrogenase1.1.1.10.448
2fgjATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.448
2fr3REACellular retinoic acid-binding protein 2/0.448
2iko7IGRenin3.4.23.150.448
2mwgFMNBlue-light photoreceptor/0.448
2ql6ADPNicotinamide riboside kinase 1/0.448
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
2wxvWXVCyclin-dependent kinase 22.7.11.220.448
2xx91NFGlutamate receptor 2/0.448
2ylzFADPhenylacetone monooxygenase1.14.13.920.448
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.448
3amfFMNFMN-binding protein/0.448
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.448
4dnaFADProbable glutathione reductase/0.448
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.448
4mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.448
4tm1FDAKtzI/0.448
4wudANPDNA gyrase subunit B/0.448
4zowCLMMultidrug transporter MdfA/0.448
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.448
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.447
1mezGDPAdenylosuccinate synthetase isozyme 1/0.447
1um0FMNChorismate synthase/0.447
1wngSAHDiphthine synthase/0.447
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.447
2cduFADNADH oxidase/0.447
2ehlSAHDiphthine synthase/0.447
2ek3SAHDiphthine synthase/0.447
2ekaSAHDiphthine synthase/0.447
2fypRDEEndoplasmin/0.447
2hu2NADC-terminal binding protein 1/0.447
2i0zFADNAD(FAD)-utilizing dehydrogenases/0.447
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.447
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.447
3clsFADElectron transfer flavoprotein subunit alpha/0.447
3h3r14HCollagen type IV alpha-3-binding protein/0.447
3mjeNDPAmphB/0.447
3qvsNADMyo-inositol-1-phosphate synthase (Ino1)/0.447
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.447
3s3tATPUniversal stress protein/0.447
3uayADNPurine nucleoside phosphorylase DeoD-type/0.447
3vn2TLSPeroxisome proliferator-activated receptor gamma/0.447
4m10ICDProstaglandin G/H synthase 21.14.99.10.447
4z4pSAHHistone-lysine N-methyltransferase 2D2.1.1.430.447
5jscFADPutative acyl-CoA dehydrogenase/0.447
1dr3TAPDihydrofolate reductase1.5.1.30.446
1egeFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.446
1gpdNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.446
1h51FMNPentaerythritol tetranitrate reductase/0.446
1mjbACOHistone acetyltransferase ESA1/0.446
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.446
1uxjNADMalate dehydrogenase/0.446
1xkdNAPIsocitrate dehydrogenase [NADP]/0.446
2a5kAZPReplicase polyprotein 1ab3.4.220.446
2b7aIZATyrosine-protein kinase JAK2/0.446
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.446
2dftADPShikimate kinase2.7.1.710.446
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.446
2eeqSAHDiphthine synthase/0.446
2ek7SAHDiphthine synthase/0.446
2g21L1BRenin3.4.23.150.446
2gfsPQBMitogen-activated protein kinase 14/0.446
2he5NDPAldo-keto reductase family 1 member C211.1.10.446
2itnANPEpidermal growth factor receptor2.7.10.10.446
2p2xSAHDiphthine synthase/0.446
2v13C40Renin3.4.23.150.446
2w06FRVCyclin-dependent kinase 22.7.11.220.446
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
3hyoADPPyridoxal kinase/0.446
3lovFADProtoporphyrinogen oxidase/0.446
3ohf3HFBeta-secretase 13.4.23.460.446
3t2zFADSulfide-quinone reductase/0.446
4a802ANMajor pollen allergen Bet v 1-A/0.446
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.446
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.446
4fko20KCyclin-dependent kinase 22.7.11.220.446
4irnFADAnaB/0.446
4kbyC2EStimulator of interferon genes protein/0.446
4oznATPAmmonium transporter/0.446
4qe6JN3Bile acid receptor/0.446
4twnB96Ephrin type-A receptor 32.7.10.10.446
4y3zF41Endothiapepsin3.4.23.220.446
1ae1NAPTropinone reductase 1/0.445
1om1IQACasein kinase II subunit alpha2.7.11.10.445
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.445
2daaDCSD-alanine aminotransferase2.6.1.210.445
2dsgSAHDiphthine synthase/0.445
2gjnFMNNitronate monooxygenase1.13.12.160.445
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.445
2hckQUETyrosine-protein kinase HCK2.7.10.20.445
2pmnK51Protein kinase 7/0.445
2q61SF1Peroxisome proliferator-activated receptor gamma/0.445
2vbdV10Isopenicillin N synthase1.21.3.10.445
2yxuATPPyridoxal kinase2.7.1.350.445
3cinNADMyo-inositol-1-phosphate synthase-related protein/0.445
3cluFADElectron transfer flavoprotein subunit alpha/0.445
3d7kD7KBenzaldehyde lyase/0.445
3dg8NDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
3mzhCMPCRP-like cAMP-activated global transcriptional regulator/0.445
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
4f3xNADPutative aldehyde dehydrogenase/0.445
4fryNADPutative signal-transduction protein with CBS domains/0.445
4jyzATPGlutamine--tRNA ligase6.1.1.180.445
4k6fNAPPutative Acetoacetyl-CoA reductase/0.445
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.445
4z24FADPutative GMC-type oxidoreductase R13510.445
1c0lFADD-amino-acid oxidase1.4.3.30.444
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1hfqMOTDihydrofolate reductase1.5.1.30.444
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1pzfA3DLactate dehydrogenase/0.444
1r6uTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.444
1rx1NAPDihydrofolate reductase1.5.1.30.444
2egbSAHDiphthine synthase/0.444
2eglSAHDiphthine synthase/0.444
2el0SAHDiphthine synthase/0.444
2g226IGRenin3.4.23.150.444
2g82NADGlyceraldehyde-3-phosphate dehydrogenase/0.444
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.444
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.444
2oapANPType II secretion system protein (GspE-2)/0.444
2pwrG4GGag-Pol polyprotein3.4.23.160.444
2qenADPWalker-Type ATPase/0.444
2yylFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.444
3cgeFADCoenzyme A disulfide reductase/0.444
3clrFADElectron transfer flavoprotein subunit alpha/0.444
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3kgcLY7Glutamate receptor 2/0.444
3qvtNAIMyo-inositol-1-phosphate synthase (Ino1)/0.444
3umvFADDeoxyribodipyrimidine photo-lyase4.1.99.30.444
3w8eNAD3-hydroxybutyrate dehydrogenase/0.444
3zs7ATPPyridoxine/pyridoxal/pyridoxamine kinase/0.444
4dx9SER_ALA_VAL_THRIntegrin beta-1/0.444
4dx9SER_ALA_VAL_THRIntegrin beta-1-binding protein 1/0.444
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.444
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.444
4jl5ADPAdenylate kinase/0.444
4u0mATPCyclic GMP-AMP synthase/0.444
4y380A9Endothiapepsin3.4.23.220.444
4z54GDPNeuronal-specific septin-3/0.444
4zohFADPutative oxidoreductase FAD-binding subunit/0.444
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
5esdTDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.444
1cg0IMOAdenylosuccinate synthetase/0.443
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1ez4NADL-lactate dehydrogenase1.1.1.270.443
1f8wFADNADH peroxidase1.11.1.10.443
1o8cNDPProbable acrylyl-CoA reductase AcuI1.3.1.840.443
2c29NAPDihydroflavonol 4-reductase/0.443
2cy0NAPShikimate dehydrogenase (NADP(+))/0.443
2dteNAIGlucose 1-dehydrogenase related protein/0.443
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.443
2ozuACOHistone acetyltransferase KAT6A/0.443
2qirCOAAminoglycoside 6-N-acetyltransferase type Ib11/0.443
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2xpvMIYTetracycline repressor protein class D/0.443
2xyuQ9GEphrin type-A receptor 42.7.10.10.443
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.443
2zm4KSMTyrosine-protein kinase Lck2.7.10.20.443
3d91REMRenin3.4.23.150.443
3fsfFSSMitogen-activated protein kinase 14/0.443
3gu83GUDeath-associated protein kinase 12.7.11.10.443
3ieuGDPGTPase Era/0.443
3mddFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.443
3mgdACOPredicted acetyltransferase/0.443
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.443
3prsRITEndothiapepsin3.4.23.220.443
3rj5NADAlcohol dehydrogenase1.1.1.10.443
3rq6APRADP-dependent (S)-NAD(P)H-hydrate dehydratase/0.443
3ryoACON-acetyltransferase Eis/0.443
3u33FADPutative acyl-CoA dehydrogenase AidB1.3.990.443
3zxsFADDeoxyribodipyrimidine photolyase-related protein/0.443
4b7xNAPProbable oxidoreductase/0.443
4do30LAFatty-acid amide hydrolase 13.5.1.990.443
4ef8FMNDihydroorotate dehydrogenase (fumarate)/0.443
4ef9FMNDihydroorotate dehydrogenase (fumarate)/0.443
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.443
4mlp2CXCryptochrome-2/0.443
4oauADP2-5A-dependent ribonuclease3.1.260.443
4ocpADPN-acetylhexosamine 1-kinase2.7.1.1620.443
4prxADPDNA gyrase subunit B/0.443
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4yaiNAIC alpha-dehydrogenase/0.443
5irnADPNucleotide binding oligomerization domain containing 2/0.443
8dfrNDPDihydrofolate reductase1.5.1.30.443
1bxoPP7Penicillopepsin-13.4.23.200.442
1dhrNADDihydropteridine reductase1.5.1.340.442
1drhNAPDihydrofolate reductase1.5.1.30.442
1ib0NADNADH-cytochrome b5 reductase 31.6.2.20.442
1joaFADNADH peroxidase1.11.1.10.442
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
1vbmYSATyrosine--tRNA ligase6.1.1.10.442
2e8sSAHDiphthine synthase/0.442
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2i4qUA4Renin3.4.23.150.442
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.442
2owgSAHDiphthine synthase/0.442
2wedPP6Penicillopepsin-13.4.23.200.442
3b9lAZZSerum albumin/0.442
3bx5304Mitogen-activated protein kinase 14/0.442
3c14GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.442
3r9uFADThioredoxin reductase/0.442
3vglANPGlucokinase/0.442
3vrtYS2Vitamin D3 receptor/0.442
3wswNADL-lactate dehydrogenase/0.442
4blrUTPNTPase P4/0.442
4dsgFADUncharacterized protein/0.442
4eepFMNPhototropin-22.7.11.10.442
4f650S9Fibroblast growth factor receptor 1/0.442
4fidGDPG protein alpha subunit, putative/0.442
4l0qNADAlcohol dehydrogenase class-3/0.442
4opgFDAConserved Archaeal protein/0.442
4panGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.442
4paoGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.442
4q71FADBifunctional protein PutA/0.442
4udqFAD5-(hydroxymethyl)furfural oxidase/0.442
4xczFONQdtf/0.442
5c1mCLRMu-type opioid receptor/0.442
1bwb146Gag-Pol polyprotein3.4.23.160.441
1iidNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.441
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.441
1l4fNCNNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.441
1pdhFASp-hydroxybenzoate hydroxylase/0.441
1rbyKEUTrifunctional purine biosynthetic protein adenosine-32.1.2.20.441
1svmATPLarge T antigen3.6.40.441
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.441
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2gekGDPPhosphatidyl-myo-inositol mannosyltransferase2.4.1.570.441
2is0I03Beta-secretase 13.4.23.460.441
2nniMTKCytochrome P450 2C8/0.441
2p3b3TLV-1 PROTEASE protein/0.441
2p3b3TLV-1 protease/0.441
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.441
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.441
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.441
3cosNADAlcohol dehydrogenase 41.1.1.10.441
3koyZ97D-ornithine 4,5-aminomutase subunit beta/0.441
3lpjZ75Beta-secretase 13.4.23.460.441
3p4tFAOPutative acyl-CoA dehydrogenase/0.441
3p7nFMNLight-activated DNA-binding protein EL222/0.441
3rdqDTBStreptavidin/0.441
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.441
3ut5LOCTubulin beta chain/0.441
3zkyWT4Isopenicillin N synthase1.21.3.10.441
4a84DXCMajor pollen allergen Bet v 1-A/0.441
4an4DUDPutative glycosyl transferase/0.441
4auxXTCTetracycline repressor protein class D/0.441
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.441
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
4fdnFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.441
4g3pUD1Bifunctional protein GlmU/0.441
4kukRBFPutative blue-light photoreceptor/0.441
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.441
4lol1YEStimulator of interferon genes protein/0.441
4m6jNDPDihydrofolate reductase1.5.1.30.441
4rww2BALmo2692 protein/0.441
4u8oFDAUDP-galactopyranose mutase/0.441
4wsqKSAAP2-associated protein kinase 12.7.11.10.441
5hwsNAP2-dehydropantoate 2-reductase/0.441
5dhhDGWNociceptin receptor/0.441
1do8NADNAD-dependent malic enzyme, mitochondrial1.1.1.380.440
1ek5NADUDP-glucose 4-epimerase/0.440
1k6vXN2Gag-Pol polyprotein3.4.23.160.440
1pjkANPCasein kinase II subunit alpha2.7.11.10.440
1udyFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.440
2c20NADUDP-glucose 4-epimerase/0.440
2e8qSAHDiphthine synthase/0.440
2fxuBIDActin, alpha skeletal muscle/0.440
2gnaGDUUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.440
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.440
2j4dFADCryptochrome DASH, chloroplastic/mitochondrial/0.440
2jcxNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.440
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.440
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.440
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.440
2woa023Macrophage metalloelastase3.4.24.650.440
2x7jTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.440
2xvw9NRSerum albumin/0.440
3ag6PAJPantothenate synthetase/0.440
3c15GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.440
3d4pNADL-lactate dehydrogenase 11.1.1.270.440
3h6vNS6Glutamate receptor 2/0.440
3i0pNADMalate dehydrogenase, putative/0.440
3mknDNBPyrimidine-specific ribonucleoside hydrolase RihB/0.440
3mw9NAIGlutamate dehydrogenase 1, mitochondrial1.4.1.30.440
3nxxNDPDihydrofolate reductase1.5.1.30.440
3ocpCMPcGMP-dependent protein kinase 12.7.11.120.440
3p2kSAM16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.440
3r3sNADPutative oxidoreductase/0.440
3s87ADPRibonucleoside-diphosphate reductase large chain 11.17.4.10.440
3tneRITCandidapepsin-13.4.23.240.440
3vy2FMNFMN-binding protein/0.440
4a4qUX9Pol protein/0.440
4dbzNDPPutative ketoacyl reductase1.3.10.440
4gk3L87Ephrin type-A receptor 32.7.10.10.440
4gyy12VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.440
4kl9NDPDihydrofolate reductase1.5.1.30.440
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.440
4pl0ANPMicrocin-J25 export ATP-binding/permease protein McjD/0.440
4qnyANPMitogen activated protein kinase, putative/0.440
4rvnCOAPhenylacetate-coenzyme A ligase/0.440
5ej9TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.440