sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2zsi | GA4 | Gibberellin receptor GID1A | 3 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2zsi | GA4 | Gibberellin receptor GID1A | 3 | 1.000 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.688 | |
| 2zsh | GA3 | Gibberellin receptor GID1A | 3 | 0.638 | |
| 3ebl | GA4 | Gibberellin receptor GID1 | / | 0.620 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.508 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.501 | |
| 2ejz | SAH | Diphthine synthase | / | 0.500 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.499 | |
| 2vut | NAD | Nitrogen metabolite repression protein nmrA | / | 0.496 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.495 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.492 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.490 | |
| 3s87 | ADP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.490 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.488 | |
| 2vuu | NAP | Nitrogen metabolite repression protein nmrA | / | 0.488 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.487 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.483 | |
| 4m2b | UPG | UDP-glucose pyrophosphorylase | / | 0.483 | |
| 3geg | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.482 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.482 | |
| 4fm8 | 0UQ | Beta-secretase 1 | 3.4.23.46 | 0.482 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.482 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.481 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.479 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.478 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.478 | |
| 3fr4 | F8A | Fatty acid-binding protein, adipocyte | / | 0.477 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.477 | |
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.477 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.476 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.476 | |
| 5a3c | NAD | SIR2 family protein | / | 0.476 | |
| 1d4d | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.475 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.475 | |
| 2e1z | B4P | Propionate kinase | / | 0.475 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.475 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.475 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.475 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.475 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.474 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.474 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.474 | |
| 2q46 | NAP | Uncharacterized protein At5g02240 | / | 0.473 | |
| 2xfs | J01 | Uncharacterized protein | / | 0.473 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.473 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.473 | |
| 4wxf | PLG | Serine hydroxymethyltransferase | / | 0.473 | |
| 1ivs | VAA | Valine--tRNA ligase | 6.1.1.9 | 0.471 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.471 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.471 | |
| 3uwl | FOZ | Thymidylate synthase | / | 0.471 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.471 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.470 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.470 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.469 | |
| 4xnw | 2ID | P2Y purinoceptor 1 | / | 0.469 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.468 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.468 | |
| 3daf | FEG | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 0.468 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.468 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.468 | |
| 1eio | GCH | Gastrotropin | / | 0.467 | |
| 2an9 | GDP | Guanylate kinase | 2.7.4.8 | 0.467 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.467 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.467 | |
| 1f4g | TP4 | Thymidylate synthase | / | 0.466 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.466 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.466 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.466 | |
| 3cvu | FAD | RE11660p | / | 0.466 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.466 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.465 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.465 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.465 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.465 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.465 | |
| 4e2d | FMN | Dehydrogenase | / | 0.465 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.465 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.465 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.465 | |
| 4rrv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.465 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.464 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 2ghl | LIB | Mitogen-activated protein kinase 14 | / | 0.464 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.464 | |
| 4mpp | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.464 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.463 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.463 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.463 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.463 | |
| 4jic | FMN | GTN Reductase | / | 0.463 | |
| 1cq7 | PY5 | Aspartate aminotransferase | 2.6.1.1 | 0.462 | |
| 2r2n | KYN | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.462 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.462 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.462 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.462 | |
| 4adc | PLP | Succinylornithine transaminase | 2.6.1.81 | 0.462 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.461 | |
| 1s17 | GNR | Peptide deformylase | / | 0.461 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.461 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.461 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.461 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.461 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.460 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.460 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.460 | |
| 4dja | FAD | (6-4) photolyase | / | 0.460 | |
| 4i8x | 6P3 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.460 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.460 | |
| 4lcg | 1WM | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.460 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.459 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.459 | |
| 1kh3 | ANP | Argininosuccinate synthase | / | 0.459 | |
| 1yqs | BSA | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.459 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.459 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.459 | |
| 3eks | CY9 | Actin-5C | / | 0.459 | |
| 3ing | NDP | Homoserine dehydrogenase related protein | / | 0.459 | |
| 3muo | ZPR | Prolyl endopeptidase | / | 0.459 | |
| 3w1t | WRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.459 | |
| 4bf9 | FMN | tRNA-dihydrouridine(16) synthase | / | 0.459 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.459 | |
| 5iw5 | NMN | NADH pyrophosphatase | / | 0.459 | |
| 1b5e | DCM | Deoxycytidylate 5-hydroxymethyltransferase | 2.1.2.8 | 0.458 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.458 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.458 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.458 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.458 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.458 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.458 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.458 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.458 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.457 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.457 | |
| 1daa | PLP | D-alanine aminotransferase | 2.6.1.21 | 0.457 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.457 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.457 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.457 | |
| 2yph | QQY | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.457 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.457 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.457 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.457 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.457 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.457 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.457 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.457 | |
| 5a3b | APR | SIR2 family protein | / | 0.457 | |
| 5bnw | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.457 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.456 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.456 | |
| 2pk3 | GDD | GDP-6-deoxy-D-mannose reductase | / | 0.456 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3b9x | NOS | Pyrimidine-specific ribonucleoside hydrolase RihB | 3.2.2.8 | 0.456 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.456 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.456 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.456 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.456 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.455 | |
| 2b36 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.455 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.455 | |
| 3jq3 | ADP | Lombricine kinase | / | 0.455 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.455 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.455 | |
| 3zgl | 10E | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | / | 0.455 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 4xr9 | NAD | CalS8 | / | 0.455 | |
| 4zqc | F6F | Tryptophan synthase alpha chain | / | 0.455 | |
| 1m8g | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.454 | |
| 1n5v | NOM | ActVA 6 protein | / | 0.454 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.454 | |
| 2fto | TMP | Thymidylate synthase | / | 0.454 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.454 | |
| 2ome | NAD | C-terminal-binding protein 2 | / | 0.454 | |
| 2pam | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.454 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.454 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.454 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 3pft | FMN | Flavin reductase | / | 0.454 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.454 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.454 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.454 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.454 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.453 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.453 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.453 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.453 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.453 | |
| 2e20 | B4P | Propionate kinase | / | 0.453 | |
| 2x0r | NAD | Malate dehydrogenase | / | 0.453 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.453 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.453 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.453 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.453 | |
| 3mkn | DNB | Pyrimidine-specific ribonucleoside hydrolase RihB | / | 0.453 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.453 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.453 | |
| 1ix1 | BB2 | Peptide deformylase | / | 0.452 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.452 | |
| 2hu2 | NAD | C-terminal binding protein 1 | / | 0.452 | |
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.452 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.452 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.452 | |
| 3m2u | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.452 | |
| 3nmn | PYV | Abscisic acid receptor PYL1 | / | 0.452 | |
| 4avl | TMP | Polymerase acidic protein | / | 0.452 | |
| 4b3a | TAC | Tetracycline repressor protein class D | / | 0.452 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.452 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.452 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.452 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.451 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.451 | |
| 1eqb | FFO | Serine hydroxymethyltransferase | 2.1.2.1 | 0.451 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.451 | |
| 1gc5 | ADP | ADP-dependent glucokinase | 2.7.1.147 | 0.451 | |
| 1i24 | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.451 | |
| 1ja0 | NAP | NADPH--cytochrome P450 reductase | / | 0.451 | |
| 1q19 | SSC | Carbapenam-3-carboxylate synthase | 6.3.3.6 | 0.451 | |
| 1v2h | GUN | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.451 | |
| 2iyp | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.451 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.451 | |
| 2wqp | WQP | Polysialic acid capsule biosynthesis protein SiaC | / | 0.451 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.451 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.451 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.451 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.451 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.450 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.450 | |
| 1rjd | SAM | Leucine carboxyl methyltransferase 1 | 2.1.1.233 | 0.450 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.450 | |
| 3a0t | ADP | Sensor histidine kinase | / | 0.450 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.450 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.450 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.450 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.450 | |
| 4qxq | 1YE | Stimulator of interferon genes protein | / | 0.450 | |
| 5cyo | GDP | Septin-9 | / | 0.450 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.449 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.449 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.449 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.449 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.449 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.449 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.449 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.449 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.449 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.449 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.449 | |
| 4die | C5P | Cytidylate kinase | / | 0.449 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.449 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.449 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.448 | |
| 1hdg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.448 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.448 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 1wkg | POI | [LysW]-aminoadipate semialdehyde transaminase | / | 0.448 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.448 | |
| 2ii6 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.448 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.448 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 3m2r | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.448 | |
| 3m2r | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.448 | |
| 3qvp | FAD | Glucose oxidase | 1.1.3.4 | 0.448 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.448 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.448 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.448 | |
| 4gyy | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.448 | |
| 4wxg | 2BO | Serine hydroxymethyltransferase | / | 0.448 | |
| 5eso | ISC | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.448 | |
| 1dxy | NAD | D-2-hydroxyisocaproate dehydrogenase | 1.1.1 | 0.447 | |
| 1fk8 | NAD | 3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase | 1.1.1.50 | 0.447 | |
| 1i59 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.447 | |
| 1k27 | MTM | S-methyl-5'-thioadenosine phosphorylase | / | 0.447 | |
| 1lkd | BP6 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.447 | |
| 1ywg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.447 | |
| 2bgm | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.447 | |
| 2dek | SAH | Diphthine synthase | / | 0.447 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.447 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.447 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 3da2 | 4MD | Carbonic anhydrase 13 | 4.2.1.1 | 0.447 | |
| 3hgo | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.447 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.447 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.447 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.447 | |
| 5ero | 210 | Fusicoccadiene synthase | 2.5.1.29 | 0.447 | |
| 1gtr | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.446 | |
| 1tys | TMP | Thymidylate synthase | / | 0.446 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.446 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.446 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.446 | |
| 3ko8 | NAD | NAD-dependent epimerase/dehydratase | / | 0.446 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.446 | |
| 3tri | NAP | Pyrroline-5-carboxylate reductase | / | 0.446 | |
| 3wqu | ATP | Cell division protein FtsA | / | 0.446 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.446 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.446 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 4jey | PLP | Acetylornithine/succinyldiaminopimelate aminotransferase | 2.6.1.11 | 0.446 | |
| 4l4x | NDP | AmphI | / | 0.446 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4rp8 | ASC | Ascorbate-specific PTS system EIIC component | / | 0.446 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.445 | |
| 1omo | NAD | Alanine dehydrogenase | / | 0.445 | |
| 1pl6 | 572 | Sorbitol dehydrogenase | 1.1.1.14 | 0.445 | |
| 1zdf | UPG | Glycogenin-1 | 2.4.1.186 | 0.445 | |
| 2b9y | FAD | Putative aminooxidase | / | 0.445 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.445 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.445 | |
| 2v1a | FMN | NPH1-1 | / | 0.445 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.445 | |
| 3qpg | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.445 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.445 | |
| 4e2b | FMN | Dehydrogenase | / | 0.445 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.445 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.445 | |
| 5e8j | SAH | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.445 | |
| 1a8r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.444 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.444 | |
| 1ftl | DNQ | Glutamate receptor 2 | / | 0.444 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.444 | |
| 1j78 | VDY | Vitamin D-binding protein | / | 0.444 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.444 | |
| 1sxj | AGS | Replication factor C subunit 1 | / | 0.444 | |
| 1ttm | 667 | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 1vhn | FMN | tRNA-dihydrouridine synthase | / | 0.444 | |
| 1zdw | FLV | Prenyltransferase | / | 0.444 | |
| 2ihu | TP9 | N(2)-(2-carboxyethyl)arginine synthase | / | 0.444 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.444 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3ele | PLP | Aminotransferase | / | 0.444 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.444 | |
| 3keo | NAD | Redox-sensing transcriptional repressor Rex | / | 0.444 | |
| 3mvm | 39P | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 3rdq | DTB | Streptavidin | / | 0.444 | |
| 4cf7 | ADP | Adenylate kinase | / | 0.444 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.444 | |
| 4isu | IKM | Glutamate receptor 2 | / | 0.444 | |
| 4jay | NAP | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.444 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.444 | |
| 1b5d | DCM | Deoxycytidylate 5-hydroxymethyltransferase | 2.1.2.8 | 0.443 | |
| 1ezv | UQ6 | Cytochrome b | / | 0.443 | |
| 1fml | RTL | Retinol dehydratase | / | 0.443 | |
| 1kmy | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.443 | |
| 1p3d | UMA | UDP-N-acetylmuramate--L-alanine ligase | 6.3.2.8 | 0.443 | |
| 1pt5 | ACO | Formyl-CoA:oxalate CoA-transferase | / | 0.443 | |
| 1t2a | NDP | GDP-mannose 4,6 dehydratase | 4.2.1.47 | 0.443 | |
| 1u2y | GOX | Pancreatic alpha-amylase | / | 0.443 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.443 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.443 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.443 | |
| 2e17 | SAH | Diphthine synthase | / | 0.443 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.443 | |
| 2z4s | ADP | Chromosomal replication initiator protein DnaA | / | 0.443 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 3qfc | NAP | NADPH--cytochrome P450 reductase | / | 0.443 | |
| 3tlc | 7MD | Microcin C7 self-immunity protein MccF | / | 0.443 | |
| 4ehu | ANP | 2-hydroxyisocaproyl-CoA dehydratase activator | / | 0.443 | |
| 4jxx | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.443 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.443 | |
| 4qys | PLR | Tryptophan synthase beta chain 2 | 4.2.1.20 | 0.443 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.443 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2ej2 | PPE | Branched-chain amino acid aminotransferase (IlvE) | / | 0.442 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.442 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.442 | |
| 2hs8 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.442 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.442 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.442 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.442 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.442 | |
| 3dhc | CYK | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.442 | |
| 3ge1 | ADP | Glycerol kinase | / | 0.442 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.442 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.442 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.442 | |
| 3ssm | SAH | Mycinamicin VI 2''-O-methyltransferase | / | 0.442 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.442 | |
| 3v2u | ATP | Protein GAL3 | / | 0.442 | |
| 3w0n | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.442 | |
| 4acu | QN7 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.442 | |
| 4ge9 | 0L0 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 4itm | ATP | Tetraacyldisaccharide 4'-kinase | / | 0.442 | |
| 4jzr | 4JR | Egl nine homolog 1 | / | 0.442 | |
| 4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.442 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.442 | |
| 1lrj | UD1 | UDP-glucose 4-epimerase | 5.1.3.2 | 0.441 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.441 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.441 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.441 | |
| 2e16 | SAH | Diphthine synthase | / | 0.441 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.441 | |
| 3b9l | AZZ | Serum albumin | / | 0.441 | |
| 3dha | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.441 | |
| 3dhb | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.441 | |
| 3h2s | NDP | Putative NADH-flavin reductase | / | 0.441 | |
| 3hlw | CE3 | Beta-lactamase | / | 0.441 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.441 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.441 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.441 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.441 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.441 | |
| 3qiz | QI2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.441 | |
| 3u9e | COA | Lmo1369 protein | / | 0.441 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.441 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.441 | |
| 4kfq | KFQ | Glutamate receptor ionotropic, NMDA 1 | / | 0.441 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.441 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.441 | |
| 4wrk | DUP | DUTPase | / | 0.441 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.441 | |
| 5fwn | NAP | Putative dehydrogenase | / | 0.441 | |
| 1clq | GDP | DNA-directed DNA polymerase | / | 0.440 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.440 | |
| 1og4 | NAI | T-cell ecto-ADP-ribosyltransferase 2 | / | 0.440 | |
| 1oj4 | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.440 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.440 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.440 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.440 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.440 | |
| 2oeg | UPG | UDP-glucose pyrophosphorylase | / | 0.440 | |
| 2p9h | IPT | Lactose operon repressor | / | 0.440 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.440 | |
| 3b2s | B2S | Trichothecene 3-O-acetyltransferase | / | 0.440 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.440 | |
| 3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.440 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.440 | |
| 3vjo | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.440 | |
| 4h4d | 10E | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | / | 0.440 | |
| 4hia | FMN | LOV protein | / | 0.440 | |
| 4i0j | 842 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4ie0 | PD2 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.440 | |
| 4ie6 | UN9 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.440 | |
| 4j0y | 1H6 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.440 | |
| 4kp7 | 1UQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.440 | |
| 4lga | A2O | Abscisic acid receptor PYL2 | / | 0.440 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.440 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.440 |