sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1fkd | 818 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1fkd | 818 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 1.000 | |
| 2fke | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.823 | |
| 1fkj | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.696 | |
| 1fkf | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.665 | |
| 3o5r | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.643 | |
| 2dg3 | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.639 | |
| 1c9h | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1B | 5.2.1.8 | 0.629 | |
| 4dh0 | MR8 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.626 | |
| 1fkb | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.624 | |
| 1bkf | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.623 | |
| 4dz2 | FK5 | Peptidyl-prolyl cis-trans isomerase | / | 0.621 | |
| 1fkl | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.616 | |
| 1qpf | 858 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.613 | |
| 4drm | 0MC | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.608 | |
| 1q6i | FK5 | FKBP-type peptidyl-prolyl cis-trans isomerase FkpA | 5.2.1.8 | 0.601 | |
| 2dg4 | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.600 | |
| 1a7x | FKA | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.599 | |
| 2dg9 | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.593 | |
| 4lay | I63 | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.593 | |
| 1fki | SB1 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.585 | |
| 4drn | 0MC | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.575 | |
| 1qpl | 587 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.566 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.564 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.564 | |
| 4qt3 | RAP | Peptidylprolyl isomerase | / | 0.562 | |
| 4drp | 0MD | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.561 | |
| 1bl4 | AP1 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.560 | |
| 4dro | 0MD | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.558 | |
| 4fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.554 | |
| 4fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.554 | |
| 1fkh | SBX | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.553 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.553 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.553 | |
| 4jfi | 1KT | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.551 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.550 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.550 | |
| 4dri | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.547 | |
| 4dri | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.547 | |
| 1nsg | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.540 | |
| 1nsg | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.540 | |
| 4drk | I63 | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.540 | |
| 1j4h | SUB | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.539 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.537 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.537 | |
| 1fkg | SB3 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.535 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.532 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.532 | |
| 3juo | AJD | Phenazine biosynthesis protein A/B | / | 0.529 | |
| 3t0i | SAH | Putative methyltransferase | / | 0.512 | |
| 2gg3 | U13 | Methionine aminopeptidase | / | 0.504 | |
| 4j4n | D44 | Peptidylprolyl isomerase | / | 0.504 | |
| 1gpu | THD | Transketolase 1 | 2.2.1.1 | 0.499 | |
| 2avx | HTF | Regulatory protein SdiA | / | 0.498 | |
| 3iu8 | T03 | Methionine aminopeptidase 2 | / | 0.496 | |
| 3b4p | 3B4 | Phenazine biosynthesis protein A/B | / | 0.494 | |
| 3w3n | RX8 | Toll-like receptor 8 | / | 0.494 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.493 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.492 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.492 | |
| 1lbm | 137 | N-(5'-phosphoribosyl)anthranilate isomerase | 5.3.1.24 | 0.491 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.491 | |
| 4zwp | M44 | Xaa-Pro dipeptidase | 3.4.13.9 | 0.491 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.490 | |
| 4iif | CTS | Beta-glucosidase 1 | 3.2.1.21 | 0.490 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.488 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.486 | |
| 4xba | 5GP | Aprataxin-like protein | 3 | 0.486 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.485 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.485 | |
| 2xje | U5P | Cytosolic purine 5'-nucleotidase | 3.1.3.5 | 0.485 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.485 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.485 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.484 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.483 | |
| 4e31 | JHZ | Methyltransferase | / | 0.483 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.482 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.482 | |
| 3mey | ATP | Amino acid--[acyl-carrier-protein] ligase 1 | 6.2.1.n2 | 0.481 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.479 | |
| 2ggb | U17 | Methionine aminopeptidase | / | 0.478 | |
| 2ixk | TDO | dTDP-4-dehydrorhamnose 3,5-epimerase | 5.1.3.13 | 0.478 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.478 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.478 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.478 | |
| 2xiq | 5AD | Methylmalonyl-CoA mutase, mitochondrial | / | 0.477 | |
| 1gax | VAA | Valine--tRNA ligase | 6.1.1.9 | 0.476 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.476 | |
| 2gg8 | U15 | Methionine aminopeptidase | / | 0.476 | |
| 3dhc | CYK | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.476 | |
| 3f8s | PF2 | Dipeptidyl peptidase 4 | / | 0.476 | |
| 5dv2 | C5P | CCR4-NOT transcription complex subunit 6-like | 3.1.13.4 | 0.476 | |
| 1fx9 | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.475 | |
| 2uuo | LK3 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.475 | |
| 3i0o | SMI | Spectinomycin phosphotransferase | / | 0.475 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.474 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.474 | |
| 1m9n | AMZ | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.473 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.473 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.473 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.473 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.473 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.472 | |
| 1x2e | ATX | Proline iminopeptidase | 3.4.11.5 | 0.472 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.472 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.472 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.472 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.472 | |
| 3qd0 | 3Q4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.472 | |
| 5i2f | BS5 | Histidine triad nucleotide-binding protein 1 | 3 | 0.472 | |
| 1pfy | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.471 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.471 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.471 | |
| 3ou2 | SAH | SAM-dependent methyltransferase | / | 0.471 | |
| 4xcz | T3Q | Qdtf | / | 0.471 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.470 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.470 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.470 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.470 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.470 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.470 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 1p4r | 354 | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.469 | |
| 1wm1 | PTB | Proline iminopeptidase | 3.4.11.5 | 0.469 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.469 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.469 | |
| 3tdv | GDP | Gentamicin resistance protein | / | 0.469 | |
| 3zj6 | VM2 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.469 | |
| 4h2u | ATP | Amino acid--[acyl-carrier-protein] ligase 1 | 6.2.1.n2 | 0.469 | |
| 4jiq | 1L5 | GTN Reductase | / | 0.469 | |
| 4s1i | PLP | Pyridoxal kinase, putative | / | 0.469 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.468 | |
| 3ix8 | TX3 | Transcriptional activator protein LasR | / | 0.468 | |
| 3vjl | W94 | Dipeptidyl peptidase 4 | / | 0.468 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.467 | |
| 3d27 | W29 | Methionine aminopeptidase | / | 0.467 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.467 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.466 | |
| 2xpc | 051 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.466 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.465 | |
| 1kw0 | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.465 | |
| 2dxf | GNP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.465 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.465 | |
| 3i5x | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.465 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.464 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.464 | |
| 1v45 | 3DG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.464 | |
| 2a2c | ADP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.464 | |
| 2r8p | T6F | Transketolase 1 | / | 0.464 | |
| 3kkz | SAM | Uncharacterized protein | / | 0.464 | |
| 3rvi | RVI | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 5c48 | URM | Histo-blood group ABO system transferase | / | 0.464 | |
| 1xuz | MMN | Capsule biosynthesis protein | / | 0.463 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.463 | |
| 3c8b | ARG_ARG_GLY_ILE_NH2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.463 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.463 | |
| 3nd6 | ATP | Phosphopantetheine adenylyltransferase | / | 0.463 | |
| 3qj0 | QI3 | Botulinum neurotoxin type A | 3.4.24.69 | 0.463 | |
| 3rth | RTH | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.463 | |
| 3vjk | M51 | Dipeptidyl peptidase 4 | / | 0.463 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.463 | |
| 3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.463 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.463 | |
| 4j0t | 6T9 | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.463 | |
| 1kia | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.462 | |
| 1w1v | ALJ | Chitinase | / | 0.462 | |
| 2oli | IOP | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.462 | |
| 3h59 | H59 | Genome polyprotein | 2.7.7.48 | 0.462 | |
| 3nx2 | FER | Ferulic acid decarboxylase | / | 0.462 | |
| 4y17 | LAE | Transcriptional regulator of ftsQAZ gene cluster | / | 0.462 | |
| 1lke | DOG | Bilin-binding protein | / | 0.461 | |
| 1qs2 | NAD | Vip2Ac | / | 0.461 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.461 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.461 | |
| 2evm | FC2 | Methionine aminopeptidase | / | 0.461 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.461 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.461 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.461 | |
| 3l3l | L3L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.461 | |
| 3nzp | PLP | Arginine decarboxylase | / | 0.461 | |
| 4d2d | ALA_ALA_ALA | Di-or tripeptide:H+ symporter | / | 0.461 | |
| 1tg2 | H2B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.460 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.460 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.460 | |
| 2fhj | MFN | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.460 | |
| 3pch | CHB | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.460 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 4lng | JAN | CaaX farnesyltransferase beta subunit Ram1 | / | 0.460 | |
| 1qvt | PRL | HTH-type transcriptional regulator QacR | / | 0.459 | |
| 2b0q | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.459 | |
| 2gg9 | U16 | Methionine aminopeptidase | / | 0.459 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.459 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 2wzg | UPG | Uncharacterized protein | / | 0.459 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.459 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.459 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.459 | |
| 3i97 | 8DR | Neuropilin-1 | / | 0.459 | |
| 3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.459 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.459 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.459 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.459 | |
| 2gl0 | ADN | Uncharacterized protein | / | 0.458 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.458 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.458 | |
| 3t6i | NC8 | Endothiapepsin | 3.4.23.22 | 0.458 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.457 | |
| 2a4x | BLM | Mitomycin-binding protein | / | 0.457 | |
| 2evc | FC3 | Methionine aminopeptidase | / | 0.457 | |
| 2pid | YSA | Tyrosine--tRNA ligase, mitochondrial | 6.1.1.1 | 0.457 | |
| 2r4t | ADP | Glycogen synthase | 2.4.1.21 | 0.457 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.457 | |
| 4xd1 | T3Q | Qdtf | / | 0.457 | |
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.457 | |
| 1s63 | 778 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.456 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.456 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.456 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.456 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.456 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.456 | |
| 1tkc | M6T | Transketolase 1 | 2.2.1.1 | 0.455 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.455 | |
| 2pja | 33Z | Carboxypeptidase B | / | 0.455 | |
| 3g5i | DNB | Pyrimidine-specific ribonucleoside hydrolase RihA | / | 0.455 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.455 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.455 | |
| 1a4w | QWE | Prothrombin | 3.4.21.5 | 0.454 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.454 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.454 | |
| 2cv1 | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.454 | |
| 2fhk | MFN | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.454 | |
| 2rgu | 356 | Dipeptidyl peptidase 4 | / | 0.454 | |
| 2zs8 | ADP | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.454 | |
| 3myt | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.454 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.454 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.453 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.453 | |
| 2cmf | F11 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 2jev | NHQ | Diamine acetyltransferase 1 | / | 0.453 | |
| 3d28 | B34 | Genome polyprotein | 2.7.7.48 | 0.453 | |
| 3gxf | IFM | Glucosylceramidase | 3.2.1.45 | 0.453 | |
| 3s2v | 3HU | Glutamate receptor ionotropic, kainate 1 | / | 0.453 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.453 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.453 | |
| 4flj | Y08 | Methionine aminopeptidase 1 | / | 0.453 | |
| 4rel | KMP | Glycosyltransferase | / | 0.453 | |
| 5p2p | DHG | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.453 | |
| 1acj | THA | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.452 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.452 | |
| 1x31 | FMN | Subunit alpha of sarocosine oxidase | / | 0.452 | |
| 1x31 | FMN | Subunit beta of sarcosine oxidase | / | 0.452 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.452 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.452 | |
| 2gg0 | U11 | Methionine aminopeptidase | / | 0.452 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 2uzt | SS3 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 2x3j | ATP | AcsD | / | 0.452 | |
| 3e32 | ED2 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.452 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.452 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.452 | |
| 3vil | SA0 | Beta-glucosidase | / | 0.452 | |
| 4e7r | 0NW | Prothrombin | 3.4.21.5 | 0.452 | |
| 4gv7 | MEW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.452 | |
| 4la7 | A1O | Abscisic acid receptor PYL2 | / | 0.452 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 1w76 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.451 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.451 | |
| 2r4u | ADP | Glycogen synthase | 2.4.1.21 | 0.451 | |
| 2r5n | TPP | Transketolase 1 | / | 0.451 | |
| 2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.451 | |
| 3iaa | TYD | CalG2 | / | 0.451 | |
| 3juq | AKD | Phenazine biosynthesis protein A/B | / | 0.451 | |
| 3n19 | FNR | Xenobiotic reductase | / | 0.451 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.451 | |
| 3pdq | KC6 | Lysine-specific demethylase 4A | 1.14.11 | 0.451 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 4br0 | AU1 | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.451 | |
| 4mm7 | 29J | Na(+):neurotransmitter symporter (Snf family) | / | 0.451 | |
| 1dfo | PLG | Serine hydroxymethyltransferase | 2.1.2.1 | 0.450 | |
| 1vrq | FMN | Subunit alpha of sarocosine oxidase | / | 0.450 | |
| 1vrq | FMN | Subunit beta of sarcosine oxidase | / | 0.450 | |
| 2vat | COA | Acetyl-CoA--deacetylcephalosporin C acetyltransferase | 2.3.1.175 | 0.450 | |
| 2xb9 | XNW | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.450 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.450 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.450 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.450 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.450 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.450 | |
| 4o30 | SAH | Probable Histone-lysine N-methyltransferase ATXR5 | 2.1.1.43 | 0.450 | |
| 4rp8 | ASC | Ascorbate-specific PTS system EIIC component | / | 0.450 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.450 | |
| 5c3j | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.450 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 1trk | TPP | Transketolase 1 | 2.2.1.1 | 0.449 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 3g0g | RUM | Dipeptidyl peptidase 4 | / | 0.449 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.449 | |
| 3q8u | ADP | Nucleoside diphosphate kinase | / | 0.449 | |
| 3ryk | TYD | dTDP-4-dehydrorhamnose 3,5-epimerase | / | 0.449 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.449 | |
| 1n77 | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.448 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.448 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 1x2b | STX | Proline iminopeptidase | 3.4.11.5 | 0.448 | |
| 1xh5 | R68 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
| 2ejz | SAH | Diphthine synthase | / | 0.448 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.448 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 3rzp | PRF | NADPH-dependent 7-cyano-7-deazaguanine reductase | / | 0.448 | |
| 3tyc | XHP | Dihydropteroate synthase | / | 0.448 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 4az2 | 9MU | Prothrombin | 3.4.21.5 | 0.448 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.448 | |
| 4wfr | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.448 | |
| 5c8a | 5AD | Probable transcriptional regulator | / | 0.448 | |
| 3vw7 | VPX | Proteinase-activated receptor 1 | / | 0.448 | |
| 1ivs | VAA | Valine--tRNA ligase | 6.1.1.9 | 0.447 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.447 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.447 | |
| 2vte | IK4 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.447 | |
| 3c8a | ARG_ARG_GLY_LEU_NH2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.447 | |
| 4ikt | TFV | Methionine aminopeptidase 1 | / | 0.447 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.447 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.447 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.447 | |
| 1dp2 | LPB | Thiosulfate sulfurtransferase | / | 0.446 | |
| 1kh2 | ATP | Argininosuccinate synthase | / | 0.446 | |
| 1oz0 | MS1 | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.446 | |
| 1w7g | MIU | Prothrombin | 3.4.21.5 | 0.446 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.446 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2p98 | YE7 | Methionine aminopeptidase | / | 0.446 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.446 | |
| 2xq0 | BES | Leukotriene A-4 hydrolase homolog | 3.3.2.6 | 0.446 | |
| 3ccc | 7AC | Dipeptidyl peptidase 4 | / | 0.446 | |
| 3dzi | RGT | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.446 | |
| 4gcm | NAP | Thioredoxin reductase | 1.8.1.9 | 0.446 | |
| 4hmb | PZZ | Phospholipase A2 VRV-PL-VIIIa | / | 0.446 | |
| 4isu | IKM | Glutamate receptor 2 | / | 0.446 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.445 | |
| 1jyw | 147 | Beta-galactosidase | 3.2.1.23 | 0.445 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.445 | |
| 1mmk | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.445 | |
| 1sa5 | BMV | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.445 | |
| 1xnz | FCD | Methionine aminopeptidase | / | 0.445 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.445 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 2wca | NP6 | O-GlcNAcase BT_4395 | / | 0.445 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.445 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 3u4o | 08E | Genome polyprotein | 2.7.7.48 | 0.445 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.445 | |
| 4na4 | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.445 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.444 | |
| 1sa4 | JAN | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 2iuz | D1H | Endochitinase B1 | 3.2.1.14 | 0.444 | |
| 2q94 | A04 | Methionine aminopeptidase | / | 0.444 | |
| 2uv0 | OHN | Transcriptional activator protein LasR | / | 0.444 | |
| 2vd7 | PD2 | Lysine-specific demethylase 4A | 1.14.11 | 0.444 | |
| 3faz | NOS | Purine nucleoside phosphorylase | / | 0.444 | |
| 3iu9 | T07 | Methionine aminopeptidase 2 | / | 0.444 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.444 | |
| 3pkc | Y08 | Methionine aminopeptidase 2 | / | 0.444 | |
| 3v0m | 5GW | Histo-blood group ABO system transferase | / | 0.444 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.444 | |
| 4bis | 8HQ | Lysine-specific demethylase 4A | 1.14.11 | 0.444 | |
| 4c1e | MCO | Beta-lactamase class B VIM-2 | / | 0.444 | |
| 4e32 | DWN | Methyltransferase | / | 0.444 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.444 | |
| 4iah | 1DX | Alr2278 protein | / | 0.444 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.443 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.443 | |
| 1th6 | OIN | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.443 | |
| 1uma | IN2 | Prothrombin | 3.4.21.5 | 0.443 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.443 | |
| 2dxi | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.443 | |
| 2fzm | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.443 | |
| 2h3w | COA | Carnitine O-acetyltransferase | 2.3.1.7 | 0.443 | |
| 2p99 | YE6 | Methionine aminopeptidase | / | 0.443 | |
| 3b6p | TMP | Three-prime repair exonuclease 1 | 3.1.11.2 | 0.443 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3ix4 | TX1 | Transcriptional activator protein LasR | / | 0.443 | |
| 4de2 | DN3 | Beta-lactamase | / | 0.443 | |
| 4eqg | A5A | Histidine triad nucleotide-binding protein 1 | 3 | 0.443 | |
| 4m0c | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.443 | |
| 4py2 | 43E | Methionine--tRNA ligase | / | 0.443 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.443 | |
| 4xz3 | COA | Acyl-CoA synthetase (NDP forming) | / | 0.443 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.443 | |
| 1a26 | CNA | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.442 | |
| 1c23 | MPH | Methionine aminopeptidase | / | 0.442 | |
| 1el4 | CTZ | Obelin | / | 0.442 | |
| 1fxf | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.442 | |
| 1kfc | IPL | Tryptophan synthase alpha chain | / | 0.442 | |
| 1que | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.442 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 2b1i | 93A | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.442 | |
| 2c1z | U2F | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.442 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.442 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.442 | |
| 2yd0 | BES | Endoplasmic reticulum aminopeptidase 1 | 3.4.11 | 0.442 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.442 | |
| 2z95 | NDP | GDP-mannose 4,6-dehydratase | / | 0.442 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.442 | |
| 3h7r | NAP | Aldo-keto reductase family 4 member C8 | / | 0.442 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.442 | |
| 3pzc | GAP | Amino acid--[acyl-carrier-protein] ligase 1 | 6.2.1.n2 | 0.442 | |
| 4jzr | 4JR | Egl nine homolog 1 | / | 0.442 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.441 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.441 | |
| 1xq0 | 4TR | Carbonic anhydrase 2 | 4.2.1.1 | 0.441 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.441 | |
| 2gg2 | U12 | Methionine aminopeptidase | / | 0.441 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.441 | |
| 3c3e | GDP | 2-phospho-L-lactate transferase | / | 0.441 | |
| 3n76 | CA2 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.441 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 3tvq | DQH | Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN | 2.1.1 | 0.441 | |
| 4ckc | SAH | mRNA-capping enzyme catalytic subunit | 2.1.1.56 | 0.441 | |
| 4j7h | TRH | PCZA361.3 | / | 0.441 | |
| 5c8d | 5AD | Probable transcriptional regulator | / | 0.441 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.441 | |
| 1ahg | TYR_PLP | Aspartate aminotransferase | 2.6.1.1 | 0.440 | |
| 2aj8 | SC3 | Dipeptidyl peptidase 4 | / | 0.440 | |
| 2cmo | M1L | Glutamate receptor 2 | / | 0.440 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.440 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.440 | |
| 3g0c | RUF | Dipeptidyl peptidase 4 | / | 0.440 | |
| 3s8p | SAM | Histone-lysine N-methyltransferase KMT5B | 2.1.1.43 | 0.440 | |
| 3w0t | HPU | Lactoylglutathione lyase | 4.4.1.5 | 0.440 | |
| 4b1e | 6T6 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4bak | M67 | Prothrombin | 3.4.21.5 | 0.440 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.440 |