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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4rrlA3SProbable threonine--tRNA ligase 26.1.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4rrlA3SProbable threonine--tRNA ligase 26.1.1.31.000
4rr7A3SProbable threonine--tRNA ligase 26.1.1.30.652
4rr6A3SProbable threonine--tRNA ligase 26.1.1.30.650
4rraA3TProbable threonine--tRNA ligase 26.1.1.30.649
4rrbA3TProbable threonine--tRNA ligase 26.1.1.30.644
4rr8A3SProbable threonine--tRNA ligase 26.1.1.30.635
4rriA3TProbable threonine--tRNA ligase 26.1.1.30.635
4rrdA3TProbable threonine--tRNA ligase 26.1.1.30.628
4rrhA3SProbable threonine--tRNA ligase 26.1.1.30.624
4rrmA3TProbable threonine--tRNA ligase 26.1.1.30.616
4rr9A3SProbable threonine--tRNA ligase 26.1.1.30.613
4rrcA3TProbable threonine--tRNA ligase 26.1.1.30.609
2hl0A3SThreonine--tRNA ligase6.1.1.30.591
4rrjA3SProbable threonine--tRNA ligase 26.1.1.30.590
4rrkA3TProbable threonine--tRNA ligase 26.1.1.30.577
3pd2A3SThreonine--tRNA ligase6.1.1.30.574
3pd3A3TThreonine--tRNA ligase6.1.1.30.574
2hl2SSAThreonine--tRNA ligase6.1.1.30.546
4rrrA3TThreonine--tRNA ligase6.1.1.30.544
4rrqA3SThreonine--tRNA ligase6.1.1.30.543
4qzuRTLRetinol-binding protein 2/0.538
4rrgA3TThreonine--tRNA ligase6.1.1.30.537
3pd4A3GThreonine--tRNA ligase6.1.1.30.522
4rrfA3SThreonine--tRNA ligase6.1.1.30.520
3w0yDS4Vitamin D3 receptor/0.516
3w0gW07Vitamin D3 receptor/0.515
2hl1A3SThreonine--tRNA ligase6.1.1.30.510
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.509
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.508
1pdhFASp-hydroxybenzoate hydroxylase/0.503
1crbRTLRetinol-binding protein 1/0.499
1rq1FADEndoplasmic oxidoreductin-11.8.40.496
3pd5TSBThreonine--tRNA ligase6.1.1.30.496
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.495
2hamC33Vitamin D3 receptor/0.495
2hasC3OVitamin D3 receptor/0.495
3w0hW12Vitamin D3 receptor/0.495
4ead0NPThymidine phosphorylase2.4.2.40.493
2po7CHDFerrochelatase, mitochondrial4.99.1.10.492
3gwfFADCyclohexanone monooxygenase/0.492
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.491
3junAKDPhenazine biosynthesis protein A/B/0.490
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.490
2lbaCHOFatty acid binding protein 6/0.489
4iteTEYVitamin D3 receptor/0.489
3oqkS52Renin3.4.23.150.488
1kquBR4Phospholipase A2, membrane associated/0.487
3v0p4GWHisto-blood group ABO system transferase/0.486
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.486
5h8tRTLRetinol-binding protein 1/0.486
1x8lOXRRetinol dehydratase/0.485
1zdwFLVPrenyltransferase/0.485
1txiTX5Vitamin D3 receptor/0.483
3h3t16HCollagen type IV alpha-3-binding protein/0.483
1bwlFMNNADPH dehydrogenase 11.6.99.10.482
1c7oPPGHemolysin/0.482
1fmjRTLRetinol dehydratase/0.482
1rp4FADEndoplasmic oxidoreductin-11.8.40.482
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.481
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.481
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.481
1al8DHPPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.480
1bwsNDPGDP-L-fucose synthase/0.480
1fp2HMOIsoflavone-7-O-methyltransferase 82.1.1.1500.480
3br3ETHTH-type transcriptional regulator QacR/0.480
3w0iO11Vitamin D3 receptor/0.480
2hb7O1CVitamin D3 receptor/0.479
3vt7VDXVitamin D3 receptor/0.479
3w5q3KLVitamin D3 receptor/0.479
4nbiD3YD-tyrosyl-tRNA(Tyr) deacylase/0.479
3ibqATPPyridoxal kinase/0.478
3w5p4OAVitamin D3 receptor/0.478
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.477
3lz6A0DCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.477
3vt45YIVitamin D3 receptor/0.477
3up3XCAaceDAF-12/0.476
4g2i0VQVitamin D3 receptor/0.476
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.475
3vtdTKDVitamin D3 receptor/0.475
4itfTFYVitamin D3 receptor/0.475
4r81FMNPredicted NADH dehydrogenase/0.475
3vt65YIVitamin D3 receptor/0.474
4enhFVXCholesterol 24-hydroxylase/0.474
4jxrACOAcetyltransferase/0.474
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.474
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.473
3emlZMAAdenosine receptor A2a/0.473
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.472
2ym1FADPhenylacetone monooxygenase1.14.13.920.471
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.471
4oztP1AEcdysone receptor, putative/0.471
5dg3U21Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase/0.471
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.470
3vtcTK3Vitamin D3 receptor/0.470
3w0c6DSVitamin D3 receptor/0.470
3zkyWT4Isopenicillin N synthase1.21.3.10.470
1rjkVDZVitamin D3 receptor/0.469
1svlADPLarge T antigen3.6.40.469
2v59LZKBiotin carboxylase6.3.4.140.469
3i0pNADMalate dehydrogenase, putative/0.469
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.469
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.469
3vrvYSDVitamin D3 receptor/0.469
4k5o1OTM1 family aminopeptidase3.4.110.469
4rupH97Vitamin D3 receptor A/0.469
1opbRETRetinol-binding protein 2/0.468
2rgoFADAlpha-Glycerophosphate Oxidase/0.468
3w0aDS5Vitamin D3 receptor/0.468
3w5rLOAVitamin D3 receptor/0.468
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.468
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.467
2p5uNADUDP-glucose 4-epimerase/0.467
2tpsTPSThiamine-phosphate synthase/0.467
3v0o4GWHisto-blood group ABO system transferase/0.467
3w0jT08Vitamin D3 receptor/0.467
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.467
4rujVDXVitamin D3 receptor A/0.467
1ppjANYCytochrome b/0.466
3q43D66M1 family aminopeptidase3.4.110.466
4bb3KKAIsopenicillin N synthase1.21.3.10.466
4dymIYZActivin receptor type-12.7.11.300.466
4fhi0S4Vitamin D3 receptor A/0.466
4lsjLSJGlucocorticoid receptor/0.466
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.466
1ikgREXD-alanyl-D-alanine carboxypeptidase3.4.16.40.465
1sm9NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.465
1zg32HIIsoflavone 4'-O-methyltransferase/0.465
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.465
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.465
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.465
2vteIK4UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.465
3oqfS51Renin3.4.23.150.465
4du82P0Mevalonate diphosphate decarboxylase/0.465
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.465
4y1bNAPAntE/0.465
1k7fIAVTryptophan synthase alpha chain/0.464
1kkq471Peroxisome proliferator-activated receptor alpha/0.464
1mrqSTRAldo-keto reductase family 1 member C1/0.464
2fhnBNIAvidin-related protein 4/5/0.464
2rg5279Mitogen-activated protein kinase 14/0.464
3h18PMSEsterase/lipase/0.464
3k4nFADPyranose 2-oxidase/0.464
3m13FADMonomeric sarcosine oxidase1.5.3.10.464
3m31FADEndoplasmic oxidoreductin-11.8.40.464
3v0m5GWHisto-blood group ABO system transferase/0.464
3w5tLHPVitamin D3 receptor/0.464
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.464
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.464
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.463
2pamTYDTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase5.3.2.30.463
3a783EVVitamin D3 receptor/0.463
3bgsDIHPurine nucleoside phosphorylase2.4.2.10.463
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.463
3qwbNDPProbable quinone oxidoreductase1.6.5.50.463
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.463
4kc4WS3Histo-blood group ABO system transferase/0.463
1dr2TAPDihydrofolate reductase1.5.1.30.462
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.462
2q8sL92Peroxisome proliferator-activated receptor gamma/0.462
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
3ndjJHZMethyltransferase/0.462
4eiyZMAAdenosine receptor A2a/0.462
4jazSTLPeroxisome proliferator-activated receptor gamma/0.462
1kzjCB3Thymidylate synthase/0.461
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.461
1n4pCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.461
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
3c16FOKAdenylate cyclase type 2/0.461
3c16FOKAdenylate cyclase type 5/0.461
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.461
4kc2WS2Histo-blood group ABO system transferase/0.461
5fsxADPUncharacterized protein/0.461
1cf3FADGlucose oxidase1.1.3.40.460
1ie9VDXVitamin D3 receptor/0.460
1s0zEB1Vitamin D3 receptor/0.460
1tehNADAlcohol dehydrogenase class-31.1.1.10.460
1zgaHMKIsoflavone 4'-O-methyltransferase/0.460
2cwfNDPDelta(1)-pyrroline-2-carboxylate/Delta(1)-piperideine-2-carboxylate reductase/0.460
2zlcVDXVitamin D3 receptor/0.460
3fznD7KBenzoylformate decarboxylase4.1.1.70.460
3gcpSB2Mitogen-activated protein kinase 14/0.460
3jpuTY4Transcriptional activator protein LasR/0.460
3nga3NGCasein kinase II subunit alpha2.7.11.10.460
3phiNDPShikimate dehydrogenase (NADP(+))/0.460
3vt3VDXVitamin D3 receptor/0.460
3w0nANPHygromycin-B 4-O-kinase2.7.1.1630.460
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.460
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.460
1kqwRTLCellular retinol-binding protein type II/0.459
2r0pK2CPutative FAD-monooxygenase/0.459
2wedPP6Penicillopepsin-13.4.23.200.459
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.459
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.459
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.459
3kpzZNEVitamin D3 receptor/0.459
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.458
1g8oU5PN-acetyllactosaminide alpha-1,3-galactosyltransferase/0.458
1ni1HFPProtein farnesyltransferase subunit beta2.5.1.580.458
1psdNADD-3-phosphoglycerate dehydrogenase1.1.1.950.458
1u1jC2F5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 12.1.1.140.458
2ab2SNLMineralocorticoid receptor/0.458
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.458
2vqbFADPutative flavin-containing monooxygenase/0.458
2xuoTZ4Acetylcholinesterase3.1.1.70.458
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.458
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.458
3n1s5GPPurine nucleoside phosphoramidase/0.458
4g1z0VPVitamin D3 receptor A/0.458
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.458
4xldBRLPeroxisome proliferator-activated receptor gamma/0.458
4zu44TGWxcM-like protein/0.458
1dr3TAPDihydrofolate reductase1.5.1.30.457
1ie8KH1Vitamin D3 receptor/0.457
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
1nhz486Glucocorticoid receptor/0.457
2hb8MVDVitamin D3 receptor/0.457
2pa7TYDTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase5.3.2.30.457
3d5qT30Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.457
3h3sH15Collagen type IV alpha-3-binding protein/0.457
3imgBZ2Pantothenate synthetase6.3.2.10.457
3inrGDUUDP-galactopyranose mutase5.4.99.90.457
3nmpPYVAbscisic acid receptor PYL2/0.457
3oq13OQCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.457
3rbqGLY_ALA_GLY_DAOProtein unc-119 homolog A/0.457
3tk3CPZCytochrome P450 2B41.14.14.10.457
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
4jq3ZOMAldo-keto reductase family 1 member C2/0.457
4l5b1UXDeoxycytidine kinase2.7.1.740.457
4twnB96Ephrin type-A receptor 32.7.10.10.457
3sn6P0GBeta-2 adrenergic receptor/0.457
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.456
2a4nCOAAac(6')-Ii protein/0.456
2cibCM6Lanosterol 14-alpha demethylase1.14.13.700.456
2zl9VDAVitamin D3 receptor/0.456
3c3xNAPEugenol synthase 11.1.1.3180.456
3jynNDPQuinone oxidoreductase/0.456
4a83DXCMajor pollen allergen Bet v 1-A/0.456
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.456
4fxy0W2Neurolysin, mitochondrial3.4.24.160.456
4g67SAHUncharacterized ACR, COG1565 superfamily/0.456
4kf1HT5Aryldialkylphosphatase3.1.8.10.456
4mwhATPCasein kinase II subunit alpha2.7.11.10.456
4nieNBHNuclear receptor ROR-gamma/0.456
4xymCOAAcyl-CoA synthetase (NDP forming)/0.456
1nzdUPGDNA beta-glucosyltransferase/0.455
1phhFADp-hydroxybenzoate hydroxylase/0.455
1pw1HELD-alanyl-D-alanine carboxypeptidase3.4.16.40.455
1q23FUAChloramphenicol acetyltransferase2.3.1.280.455
2harOCCVitamin D3 receptor/0.455
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.455
2watCOAFatty acid synthase subunit alpha2.3.1.860.455
3af0GDPPantothenate kinase2.7.1.330.455
3biy01KHistone acetyltransferase p300/0.455
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3h3r14HCollagen type IV alpha-3-binding protein/0.455
3il1B5DGlutamate receptor 2/0.455
3q44D50M1 family aminopeptidase3.4.110.455
3vrtYS2Vitamin D3 receptor/0.455
4at0FADPossible succinate dehydrogenase/0.455
4g95OAGDihydrofolate reductase1.5.1.30.455
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.455
4jnm1LJNicotinamide phosphoribosyltransferase2.4.2.120.455
1bsvNDPGDP-L-fucose synthase/0.454
1dxyNADD-2-hydroxyisocaproate dehydrogenase1.1.10.454
1kw8BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.454
1rkhVD2Vitamin D3 receptor/0.454
2bu9HFVIsopenicillin N synthase1.21.3.10.454
2c2aADPSensor histidine kinase/0.454
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.454
2ea2F77Methionine aminopeptidase 2/0.454
2xviFADPutative flavin-containing monooxygenase/0.454
2znq401Peroxisome proliferator-activated receptor delta/0.454
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
3ohh3HHBeta-secretase 13.4.23.460.454
3pm1ETHTH-type transcriptional regulator QacR/0.454
3r5yF42Uncharacterized protein/0.454
3ufl508Beta-secretase 13.4.23.460.454
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.454
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.454
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.453
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.453
1upw444Oxysterols receptor LXR-beta/0.453
1vbiNADMalate/L-lactate dehydrogenase family protein/0.453
2hcdBIVVitamin D3 receptor A/0.453
2ou2ACOHistone acetyltransferase KAT5/0.453
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.453
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.453
2vqqTFGHistone deacetylase 43.5.1.980.453
2vtdLKMUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.453
2wi72KLHeat shock protein HSP 90-alpha/0.453
3akn11DFatty acid-binding protein, intestinal/0.453
3b9oFMNAlkane monoxygenase/0.453
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.453
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.453
4ia1BIVVitamin D3 receptor A/0.453
4mv8ACPBiotin carboxylase6.3.4.140.453
1m4dCOAAminoglycoside 2'-N-acetyltransferase2.3.10.452
1swpBTNStreptavidin/0.452
2belCBOCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.452
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.452
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.452
3da24MDCarbonic anhydrase 134.2.1.10.452
3lqfNADGalactitol dehydrogenase/0.452
3n33AESBeta-peptidyl aminopeptidase BapA/0.452
3vruYS3Vitamin D3 receptor/0.452
3zoiM2WIsopenicillin N synthase1.21.3.10.452
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.452
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.452
4u0oMTALipoyl synthase 2/0.452
1d2sDHTSex hormone-binding globulin/0.451
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.451
1fxsNAPGDP-L-fucose synthase/0.451
1jnrFADAdenylylsulfate reductase, subunit A (AprA)/0.451
1oc1ASVIsopenicillin N synthase1.21.3.10.451
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.451
1u1gBBBUridine phosphorylase2.4.2.30.451
1v93FADMethylenetetrahydrofolate reductase/0.451
2a0yDIHPurine nucleoside phosphorylase2.4.2.10.451
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.451
2g263LGRenin3.4.23.150.451
2xlpFADPutative flavin-containing monooxygenase/0.451
2xpc051UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.451
3pqbVGPPutative oxidoreductase/0.451
3qls55VDihydrofolate reductase1.5.1.30.451
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.451
3zhvTDWMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.451
4a8v2ANMajor pollen allergen Bet v 1-J/0.451
4bfsZVSPantothenate kinase2.7.1.330.451
4ejh0QACytochrome P450 2A131.14.14.10.451
4g2h0VQVitamin D3 receptor A/0.451
4nxvGDPMitochondrial dynamics protein MID51/0.451
4u07ATPAdenosine monophosphate-protein transferase FICD2.7.7.n10.451
4wsoNADProbable nicotinate-nucleotide adenylyltransferase/0.451
1drhNAPDihydrofolate reductase1.5.1.30.450
1g63FMNEpidermin decarboxylase4.1.10.450
1pqc444Oxysterols receptor LXR-beta/0.450
1rk3VDXVitamin D3 receptor/0.450
2cekN8TAcetylcholinesterase3.1.1.70.450
2iltNN1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
2z3uCRRCytochrome P450/0.450
2z9dFMNFMN-dependent NADH-azoreductase/0.450
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.450
3bw4FMNPutative 2-nitropropane dioxygenase/0.450
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.450
3f63GTXGlutathione transferase GST1-4/0.450
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.450
3gstGPRGlutathione S-transferase Mu 12.5.1.180.450
3p82FMNPentaerythritol tetranitrate reductase/0.450
3q9bB3NAcetylpolyamine amidohydrolase/0.450
3rbqGLY_ALA_GLY_ALA_DAOProtein unc-119 homolog A/0.450
3vt9YI4Vitamin D3 receptor/0.450
4dpuAGSMevalonate diphosphate decarboxylase/0.450
4g20484Vitamin D3 receptor A/0.450
4xwtU5PRibonuclease J/0.450
4yauFADNADPH--cytochrome P450 reductase/0.450
4yekTHMThymidine phosphorylase/0.450
5k2cZMAAdenosine receptor A2a/0.450
4djhJDCKappa-type opioid receptor/0.450
1bnnAL1Carbonic anhydrase 24.2.1.10.449
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.449
1txtCAAHMG-CoA synthase/0.449
2fzwNADAlcohol dehydrogenase class-31.1.1.10.449
2iyaZIOOleandomycin glycosyltransferase/0.449
2ovhAS0Progesterone receptor/0.449
2xlsFADPutative flavin-containing monooxygenase/0.449
2y8qADP5'-AMP-activated protein kinase subunit gamma-1/0.449
3cgdCOACoenzyme A disulfide reductase/0.449
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3g5qFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.449
3n71SFGHistone-lysine N-methyltransferase Smyd1/0.449
3nxxNDPDihydrofolate reductase1.5.1.30.449
3zhuTD8Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.449
4lfiGNPCasein kinase II subunit alpha2.7.11.10.449
4m9aFDAAcyl-CoA dehydrogenase/0.449
4u0sADPAdenosine monophosphate-protein transferase FICD2.7.7.n10.449
5g53NECAdenosine receptor A2a/0.449
5iu86DZAdenosine receptor A2a/0.449
1fmlRTLRetinol dehydratase/0.448
1ia3TQ5Dihydrofolate reductase1.5.1.30.448
1ni12C5Protein farnesyltransferase subunit beta2.5.1.580.448
1pgtGTXGlutathione S-transferase P2.5.1.180.448
1s5kCOAAminoglycoside N(6')-acetyltransferase type 1/0.448
1swtBTNStreptavidin/0.448
1y0s331Peroxisome proliferator-activated receptor delta/0.448
2bgjFADNADPH:ferredoxin reductase/0.448
2o4jVD4Vitamin D3 receptor/0.448
2oaxSNLMineralocorticoid receptor/0.448
2tplHPPTyrosine phenol-lyase4.1.99.20.448
2v58LZJBiotin carboxylase6.3.4.140.448
2y37A54Nitric oxide synthase, inducible1.14.13.390.448
3g8eIS1Nicotinamide phosphoribosyltransferase2.4.2.120.448
3lt2FT3Enoyl-ACP reductase/0.448
3oafOAGDihydrofolate reductase1.5.1.30.448
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
3ts1TYATyrosine--tRNA ligase6.1.1.10.448
3vsoEK1Peroxisome proliferator-activated receptor gamma/0.448
3zsyOM3Integrase/0.448
4bfzZVZPantothenate kinase2.7.1.330.448
4g1y0VOVitamin D3 receptor A/0.448
4i6gFADCryptochrome-2/0.448
4jln18VDeoxycytidine kinase2.7.1.740.448
4k28NADShikimate dehydrogenase family protein/0.448
4xz3COAAcyl-CoA synthetase (NDP forming)/0.448
1ay0TPPTransketolase 12.2.1.10.447
1g6oADPCag alpha/0.447
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.447
1rkgVD1Vitamin D3 receptor/0.447
1uamSAHtRNA (guanine-N(1)-)-methyltransferase2.1.1.2280.447
2abi1CAMineralocorticoid receptor/0.447
2du8FADD-amino-acid oxidase1.4.3.30.447
2hc4VDXVitamin D3 receptor A/0.447
2jb4A14Isopenicillin N synthase1.21.3.10.447
2o12FMNChorismate synthase/0.447
2oazI96Methionine aminopeptidase 2/0.447
2p33J07Mitogen-activated protein kinase 102.7.11.240.447
2rehFADNitroalkane oxidase1.7.3.10.447
2v2qNVG4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.447
2vbpVB1Isopenicillin N synthase1.21.3.10.447
2zbaZBATrichothecene 3-O-acetyltransferase/0.447
3af1GDPPantothenate kinase2.7.1.330.447
3i2834NBifunctional epoxide hydrolase 23.3.2.100.447
3oibFDAPutative acyl-CoA dehydrogenase/0.447
3qt62P0Mevalonate diphosphate decarboxylase/0.447
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.447
3s79ASDAromatase1.14.14.140.447
3vt5YI2Vitamin D3 receptor/0.447
3zksWZVBeta-secretase 23.4.23.450.447
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4i7fNVEGag-Pol polyprotein2.7.7.490.447
4kc1WS1Histo-blood group ABO system transferase/0.447
4kvzSAHPtnL protein/0.447
4li81XQTankyrase-12.4.2.300.447
4m4821BSodium-dependent dopamine transporter/0.447
4ri1ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase2.3.1.2020.447
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.447
3pwhZMAAdenosine receptor A2a/0.447
1aj8COACitrate synthase/0.446
1b4pGPSGlutathione S-transferase Mu 2/0.446
1g1aNADdTDP-glucose 4,6-dehydratase/0.446
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1jolFFODihydrofolate reductase1.5.1.30.446
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.446
1obnASVIsopenicillin N synthase1.21.3.10.446
1pd9CO4Dihydrofolate reductase1.5.1.30.446
1rfgGMPPurine nucleoside phosphorylase2.4.2.10.446
1s3zCOAAminoglycoside N(6')-acetyltransferase type 1/0.446
2a2dANPN-acetylgalactosamine kinase2.7.1.1570.446
2ay3MPPAromatic-amino-acid aminotransferase2.6.1.570.446
2fk8SAMHydroxymycolate synthase MmaA42.1.10.446
2gv8NDPThiol-specific monooxygenase1.14.130.446
2hs6FMN12-oxophytodienoate reductase 31.3.1.420.446
2iko7IGRenin3.4.23.150.446
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.446
2qimZEAClass 10 plant pathogenesis-related protein/0.446
2rc4ACOHistone acetyltransferase KAT6A/0.446
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.446
3b70NAPEnoyl reductase LovC10.446
3br2DEQHTH-type transcriptional regulator QacR/0.446
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.446
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3egvSAHRibosomal protein L11 methyltransferase2.1.10.446
3f4bTCLEnoyl-acyl carrier protein reductase/0.446
3gf4UPGUDP-galactopyranose mutase5.4.99.90.446
3hf6LX0Tryptophan 5-hydroxylase 11.14.16.40.446
3s1dZIRCytokinin dehydrogenase 11.5.99.120.446
3sdi3SDProteasome subunit beta type-53.4.25.10.446
3sdi3SDProteasome subunit beta type-63.4.25.10.446
3stw2TDMethylketone synthase I/0.446
3toxNAPPutative oxidoreductase/0.446
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.446
4a81DXCMajor pollen allergen Bet v 1-A/0.446
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
4bcaFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.446
4bj9UHBTankyrase-22.4.2.300.446
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.446
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.446
4kxjP34Nucleoprotein/0.446
4nr42LKCREB-binding protein/0.446
4xiwAZMCarbonic anhydrase, alpha type/0.446
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.445
1s19MC9Vitamin D3 receptor/0.445
1uymPU3Heat shock protein HSP 90-beta/0.445
1xddAAYIntegrin alpha-L/0.445
1xdpATPPolyphosphate kinase/0.445
2aa6STRMineralocorticoid receptor/0.445
2cdaNAPGlucose 1-dehydrogenase/0.445
2e9p77ASerine/threonine-protein kinase Chk12.7.11.10.445
2vbdV10Isopenicillin N synthase1.21.3.10.445
2xvq9DSSerum albumin/0.445
2zjmF1MBeta-secretase 13.4.23.460.445
3a1nNADNDP-sugar epimerase/0.445
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.445
3ix4TX1Transcriptional activator protein LasR/0.445
3kb6NADD-lactate dehydrogenase/0.445
3mnrSD1Heat shock protein HSP 90-alpha/0.445
3p3zP3ZPutative cytochrome P450/0.445
3tfq07MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
3v0tATRPerakine reductase1.1.1.3170.445
3vrwYS5Vitamin D3 receptor/0.445
3zc5W9ZHepatocyte growth factor receptor2.7.10.10.445
4dieC5PCytidylate kinase/0.445
4e2dFMNDehydrogenase/0.445
4fi1ATPCasein kinase II subunit alpha2.7.11.10.445
4h6kFMNNADPH dehydrogenase 11.6.99.10.445
4l0qNADAlcohol dehydrogenase class-3/0.445
4l4xNDPAmphI/0.445
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.445
1di8DTQCyclin-dependent kinase 22.7.11.220.444
1dirNADDihydropteridine reductase1.5.1.340.444
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.444
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.444
1mv8GDXGDP-mannose 6-dehydrogenase1.1.1.1320.444
1uzwCDHIsopenicillin N synthase1.21.3.10.444
2e20B4PPropionate kinase/0.444
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2nmtNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.444
2rqfJH3Hemolymph juvenile hormone binding protein/0.444
2rr1W8RGenome polyprotein/0.444
2vq7FADPutative flavin-containing monooxygenase/0.444
3a4vNADNDP-sugar epimerase/0.444
3bgxMEFThymidylate synthase/0.444
3bqdDAYGlucocorticoid receptor/0.444
3dmhSAMProbable ribosomal RNA small subunit methyltransferase/0.444
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.444
3ntgD72Prostaglandin G/H synthase 21.14.99.10.444
3o6o94MHeat shock protein 83/0.444
3ogwIMNLactoperoxidase1.11.1.70.444
3own3OWRenin3.4.23.150.444
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.444
3up0D7SaceDAF-12/0.444
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.444
3wycNAPMeso-diaminopimelate D-dehydrogenase1.4.1.160.444
4bkqNAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.444
4in44IDKelch-like ECH-associated protein 1/0.444
4jtrIZPAldo-keto reductase family 1 member C2/0.444
4kw51W6Decaprenylphosphoryl-beta-D-ribose oxidase/0.444
4ma628EAra h 8 allergen/0.444
4q0kGA3Phytohormone-binding protein/0.444
4uugPXGBranched-chain amino acid aminotransferase, putative/0.444
4v12POGMaoC like domain protein/0.444
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.444
4yafFADNADPH--cytochrome P450 reductase/0.444
5bt42LOBromodomain-containing protein 4/0.444
5hs1VORLanosterol 14-alpha demethylase/0.444
1f5fDHTSex hormone-binding globulin/0.443
1hrvSDZGenome polyprotein/0.443
1in5ADPHolliday junction ATP-dependent DNA helicase RuvB/0.443
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
1ya3STRMineralocorticoid receptor/0.443
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.443
2xvfFADPutative flavin-containing monooxygenase/0.443
2xytTC9Soluble acetylcholine receptor/0.443
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.443
3dr1C5DVitamin D3 receptor A/0.443
3elbC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.443
3gqvNAPEnoyl reductase LovC10.443
3hdyGDUUDP-galactopyranose mutase/0.443
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.600.443
3imeBZ2Pantothenate synthetase6.3.2.10.443
3mdvCL6Cholesterol 24-hydroxylase/0.443
3p67FMNPentaerythritol tetranitrate reductase/0.443
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.443
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.443
3vtbTKAVitamin D3 receptor/0.443
4cgiNZLIntegrase/0.443
4g1d0VKVitamin D3 receptor A/0.443
4o701QKBromodomain-containing protein 4/0.443
4q71FADBifunctional protein PutA/0.443
4qmySTUSerine/threonine-protein kinase 242.7.11.10.443
4r87COASpermidine N(1)-acetyltransferase/0.443
4rbs0RVMetallo-beta-lactamase type 2/0.443
5hwpCOAHydroxymethylglutaryl-CoA synthase/0.443
5iubCLRAdenosine receptor A2a/0.443
4s0vSUVOrexin receptor type 2/0.443
1eupASD6-deoxyerythronolide B hydroxylase/0.442
1p31EPUUDP-N-acetylmuramate--L-alanine ligase6.3.2.80.442
1rftPXMPyridoxal kinase2.7.1.350.442
1rfuADPPyridoxal kinase2.7.1.350.442
1zw9H64ATP-dependent molecular chaperone HSP82/0.442
2amaDHTAndrogen receptor/0.442
2cntCOARibosomal-protein-alanine acetyltransferase/0.442
2dvlFADAcyl-CoA dehydrogenase/0.442
2fiwACOGCN5-related N-acetyltransferase:Aminotransferase, class-II/0.442
2fpcSCGStrictosidine synthase4.3.3.20.442
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.442
2gstGPSGlutathione S-transferase Mu 12.5.1.180.442
2j83BATUlilysin3.4.240.442
2o4rVD5Vitamin D3 receptor/0.442
2p1u4TNRetinoic acid receptor RXR-alpha/0.442
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.442
2v5aLZLBiotin carboxylase6.3.4.140.442
2xgs44PUncharacterized protein/0.442
2zs9ADPPantothenate kinase2.7.1.330.442
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
3jziJZLBiotin carboxylase6.3.4.140.442
3k8q22APurine nucleoside phosphorylase2.4.2.10.442
3lkhLT6Genome polyprotein2.7.7.480.442
3oxfSAHHistone-lysine N-methyltransferase SMYD32.1.1.430.442
3q7fED2Uncharacterized protein/0.442
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.442
3zuyTCHTransporter/0.442
4az3S35Lysosomal protective protein3.4.16.50.442
4b4w9L9Bifunctional protein FolD/0.442
4b8zGDPGDP-L-fucose synthase1.1.1.2710.442
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.442
4kqrVPPPeptidoglycan D,D-transpeptidase FtsI/0.442
4mr61K0Bromodomain-containing protein 2/0.442
4o2bLOCTubulin beta-2B chain/0.442
4xbaGMPAprataxin-like protein30.442
5c3aURMHisto-blood group ABO system transferase/0.442
1gij2PUCyclin-dependent kinase 22.7.11.220.441
1jnzFADAdenylylsulfate reductase, subunit A (AprA)/0.441
1nhgTCLEnoyl-ACP reductase/0.441
1osvCHCBile acid receptor/0.441
1rfvADPPyridoxal kinase2.7.1.350.441
1rj6AZMCarbonic anhydrase 144.2.1.10.441
1zgyBRLPeroxisome proliferator-activated receptor gamma/0.441
2bl4NADLactaldehyde reductase1.1.1.770.441
2dxdANPNucleoside diphosphate kinase2.7.4.60.441
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.441
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.441
2oyuIMSProstaglandin G/H synthase 11.14.99.10.441
2uxoTACHTH-type transcriptional regulator TtgR/0.441
2w6oOA3Biotin carboxylase6.3.4.140.441
2zulSAMProbable ribosomal RNA small subunit methyltransferase/0.441
3ix3OHNTranscriptional activator protein LasR/0.441
3k9uACOSpermidine N(1)-acetyltransferase/0.441
3lxeTORCarbonic anhydrase 14.2.1.10.441
3nr4PYVAbscisic acid receptor PYL2/0.441
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3sp9IL2Peroxisome proliferator-activated receptor delta/0.441
3wv9FEGHmd co-occurring protein HcgE/0.441
4a99FADTetX family tetracycline inactivation enzyme/0.441
4cf1IY7Integrase/0.441
4iarERM5-hydroxytryptamine receptor 1B/0.441
4j0v1H7Beta-secretase 13.4.23.460.441
4knzCB3Thymidylate synthase/0.441
4ly91YYGlucokinase regulatory protein/0.441
4nh82LCHeat shock protein HSP 90-alpha/0.441
4q0a4OAVitamin D3 receptor A/0.441
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.441
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
5hsaFASAlcohol oxidase 11.1.3.130.441
5iu4ZMAAdenosine receptor A2a/0.441
1bn1AL5Carbonic anhydrase 24.2.1.10.440
1cg4IMOAdenylosuccinate synthetase/0.440
1ddtAPUDiphtheria toxin/0.440
1ek5NADUDP-glucose 4-epimerase/0.440
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1kfbIGPTryptophan synthase alpha chain/0.440
1kuyCOTSerotonin N-acetyltransferase/0.440
1u1d181Uridine phosphorylase2.4.2.30.440
1wsvTHHAminomethyltransferase, mitochondrial/0.440
1ygkRRCPyridoxal kinase2.7.1.350.440
2g1s4IGRenin3.4.23.150.440
2gjlFMNNitronate monooxygenase1.13.12.160.440
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.440
2uxhQUEHTH-type transcriptional regulator TtgR/0.440
2vttLZDCyclin-dependent kinase 22.7.11.220.440
2wd9IBPAcyl-coenzyme A synthetase ACSM2A, mitochondrial6.2.1.20.440
2ym2NAPPhenylacetone monooxygenase1.14.13.920.440
3a25SAMtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase/0.440
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3h0a9RARetinoic acid receptor RXR-alpha/0.440
3hwxTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.440
3i5xANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.440
3k7mFAD6-hydroxy-L-nicotine oxidase/0.440
3ogkOGKCoronatine-insensitive protein 1/0.440
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.440
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.440
4b67NAPL-ornithine N(5)-monooxygenase/0.440
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.440
4dy4FMNNAD(P)H dehydrogenase (quinone)/0.440
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.440
4o71CPBBromodomain-containing protein 4/0.440
4phlPILPhosphodiesterase/0.440
4pnmNU1Tankyrase-22.4.2.300.440
4qa2SHHHistone deacetylase 83.5.1.980.440