sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4pzk | SAH | Putative tRNA (cytidine(34)-2'-O)-methyltransferase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4pzk | SAH | Putative tRNA (cytidine(34)-2'-O)-methyltransferase | / | 1.000 | |
| 4kgn | SAH | tRNA (cytidine(34)-2'-O)-methyltransferase | / | 0.589 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.520 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.512 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.510 | |
| 3nk7 | SAM | 23S rRNA (adenosine(1067)-2'-O)-methyltransferase | / | 0.506 | |
| 4xbo | SAH | tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ | 2.1.1.200 | 0.504 | |
| 2ha8 | SAH | Probable methyltransferase TARBP1 | / | 0.501 | |
| 3n4k | SAH | tRNA (cytidine(34)-2'-O)-methyltransferase | / | 0.499 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.498 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.495 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.494 | |
| 4cnf | MTA | SpoU rRNA methylase | / | 0.494 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.493 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.493 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.491 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.491 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.489 | |
| 3bbd | SAH | Ribosomal RNA small subunit methyltransferase Nep1 | 2.1.1 | 0.489 | |
| 2i3g | NAP | N-acetyl-gamma-glutamyl-phosphate reductase | 1.2.1.38 | 0.488 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.488 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.488 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.487 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.487 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.486 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.486 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.485 | |
| 1mxi | SAH | tRNA (cytidine(34)-2'-O)-methyltransferase | / | 0.484 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.484 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.483 | |
| 3oij | SAH | Ribosomal RNA small subunit methyltransferase NEP1 | / | 0.483 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.481 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.481 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.480 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.480 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.480 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.480 | |
| 4jwh | SAH | tRNA (guanine(9)-N1)-methyltransferase | / | 0.480 | |
| 1j3k | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.479 | |
| 2dgn | DOI | Adenylosuccinate synthetase isozyme 1 | / | 0.479 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.479 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.479 | |
| 2e8h | SAH | Diphthine synthase | / | 0.478 | |
| 3isj | A8D | Pantothenate synthetase | 6.3.2.1 | 0.478 | |
| 2yy8 | SAM | tRNA (cytidine(56)-2'-O)-methyltransferase | / | 0.477 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.476 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.476 | |
| 1cg4 | IMO | Adenylosuccinate synthetase | / | 0.475 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.475 | |
| 2dsi | SAH | Diphthine synthase | / | 0.475 | |
| 4wzh | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.475 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.475 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.474 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.473 | |
| 2daa | DCS | D-alanine aminotransferase | 2.6.1.21 | 0.473 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.473 | |
| 2gfd | RDA | Endoplasmin | / | 0.473 | |
| 2owu | SAH | Diphthine synthase | / | 0.473 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.473 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.473 | |
| 3wle | NAD | (R)-specific carbonyl reductase | / | 0.473 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.472 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.472 | |
| 2egl | SAH | Diphthine synthase | / | 0.472 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.472 | |
| 3mt8 | 17T | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.472 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.471 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.471 | |
| 2p5f | SAH | Diphthine synthase | / | 0.471 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.471 | |
| 3ivg | FG5 | Pantothenate synthetase | 6.3.2.1 | 0.471 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.471 | |
| 2uuv | FAD | Alkyldihydroxyacetonephosphate synthase | 2.5.1.26 | 0.470 | |
| 3kgc | LY7 | Glutamate receptor 2 | / | 0.470 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.470 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.470 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.470 | |
| 4tle | AGS | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.470 | |
| 4y0k | NAP | AntE | / | 0.470 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.469 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.469 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.469 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.469 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.468 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.468 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.468 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.468 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.468 | |
| 3wsw | NAD | L-lactate dehydrogenase | / | 0.468 | |
| 4cng | SAH | SpoU rRNA methylase | / | 0.468 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.468 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.467 | |
| 2jcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.467 | |
| 2ylr | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.467 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.467 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.467 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.467 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.466 | |
| 1heu | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.466 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.466 | |
| 2p6i | SAH | Diphthine synthase | / | 0.466 | |
| 3etd | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.466 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.466 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.465 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.465 | |
| 2zja | ACP | ATP-dependent DNA helicase Hel308 | / | 0.465 | |
| 3f3s | NAD | Lambda-crystallin homolog | / | 0.465 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.465 | |
| 4fue | 7UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.465 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.465 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.464 | |
| 1p0f | NAP | NADP-dependent alcohol dehydrogenase | 1.1.1.2 | 0.464 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.464 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.464 | |
| 2vht | ATP | NTPase P4 | / | 0.464 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.464 | |
| 3cls | FAD | Electron transfer flavoprotein subunit alpha | / | 0.464 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.464 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.464 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.464 | |
| 1u2y | GOX | Pancreatic alpha-amylase | / | 0.463 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.463 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.463 | |
| 2gmj | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.463 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.463 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.463 | |
| 3ox4 | NAD | Alcohol dehydrogenase 2 | 1.1.1.1 | 0.463 | |
| 4yvk | SFG | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.463 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.462 | |
| 1p9p | SAH | tRNA (guanine-N(1)-)-methyltransferase | / | 0.462 | |
| 1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.462 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.462 | |
| 2egb | SAH | Diphthine synthase | / | 0.462 | |
| 2pci | SAH | Diphthine synthase | / | 0.462 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.462 | |
| 4xr9 | NAD | CalS8 | / | 0.462 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.461 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.461 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.461 | |
| 1rbm | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.461 | |
| 1ual | SAH | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.461 | |
| 2ejz | SAH | Diphthine synthase | / | 0.461 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.461 | |
| 3gwd | NAP | Cyclohexanone monooxygenase | / | 0.461 | |
| 3ieu | GDP | GTPase Era | / | 0.461 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.461 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.461 | |
| 2ejk | SAH | Diphthine synthase | / | 0.460 | |
| 2q46 | NAP | Uncharacterized protein At5g02240 | / | 0.460 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.460 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.460 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.460 | |
| 3ut5 | LOC | Tubulin beta chain | / | 0.460 | |
| 5c46 | GSP | Ras-related protein Rab-11A | / | 0.460 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.459 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.459 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.459 | |
| 1yqd | NAP | Sinapyl alcohol dehydrogenase | / | 0.459 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.459 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.459 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.459 | |
| 2x6t | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.459 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.459 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.459 | |
| 3ms4 | 21N | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.459 | |
| 3w4y | FAD | Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 1.8.3.2 | 0.459 | |
| 4o8a | FAD | Bifunctional protein PutA | 1.2.1.88 | 0.459 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.459 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.458 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.458 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.458 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.458 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.458 | |
| 2vna | NAP | Prostaglandin reductase 2 | 1.3.1.48 | 0.458 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.458 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.458 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.458 | |
| 3wid | NAP | Glucose 1-dehydrogenase | / | 0.458 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.458 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.458 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.458 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.458 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.458 | |
| 4x3l | MTA | RNA 2'-O ribose methyltransferase | / | 0.458 | |
| 5a3b | APR | SIR2 family protein | / | 0.458 | |
| 5jyd | NAD | Short chain dehydrogenase | / | 0.458 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.457 | |
| 1ptj | NAP | NAD(P) transhydrogenase subunit beta | 1.6.1.2 | 0.457 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.457 | |
| 1tv8 | SAM | GTP 3',8-cyclase | 4.1.99.18 | 0.457 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.457 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.457 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.457 | |
| 2e8q | SAH | Diphthine synthase | / | 0.457 | |
| 2emu | SAH | Diphthine synthase | / | 0.457 | |
| 2x0r | NAD | Malate dehydrogenase | / | 0.457 | |
| 3gob | HXX | DdmC | / | 0.457 | |
| 3mpt | 1GK | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 4ej0 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.457 | |
| 4la1 | FAD | Thioredoxin glutathione reductase | / | 0.457 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.457 | |
| 4wbn | GTP | Tubulin alpha-1B chain | / | 0.457 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.456 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.456 | |
| 2hut | SAH | Diphthine synthase | / | 0.456 | |
| 2pck | SAH | Diphthine synthase | / | 0.456 | |
| 2r8o | T5X | Transketolase 1 | / | 0.456 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.456 | |
| 3h6v | NS6 | Glutamate receptor 2 | / | 0.456 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.456 | |
| 3zcs | CAW | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.456 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 4jwf | SAH | tRNA (guanine(9)-N1)-methyltransferase | / | 0.456 | |
| 4pvd | NDP | NADPH-dependent methylglyoxal reductase GRE2 | / | 0.456 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.456 | |
| 1cdo | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.455 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.455 | |
| 1h69 | ARH | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 1jue | FMN | Dihydroorotate dehydrogenase A (fumarate) | 1.3.98.1 | 0.455 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1yre | COA | Uncharacterized protein | / | 0.455 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.455 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.455 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.455 | |
| 3axk | NDP | Ribulose bisphosphate carboxylase large chain | 4.1.1.39 | 0.455 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3o0o | 5AD | Vitamin B12-dependent ribonucleotide reductase | / | 0.455 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.455 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.455 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.455 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.454 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.454 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.454 | |
| 2egv | SAM | Ribosomal RNA small subunit methyltransferase E | 2.1.1.193 | 0.454 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.454 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.454 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.454 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.454 | |
| 3e2s | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.454 | |
| 3enk | UPG | UDP-glucose 4-epimerase | / | 0.454 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.454 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.454 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.454 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.454 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.454 | |
| 5dp2 | NAP | CurF | / | 0.454 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.453 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.453 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.453 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.453 | |
| 2bgi | FAD | NADPH:ferredoxin reductase | / | 0.453 | |
| 2e08 | SAH | Diphthine synthase | / | 0.453 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.453 | |
| 2pch | SAH | Diphthine synthase | / | 0.453 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.453 | |
| 2y8l | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.453 | |
| 3cz7 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.453 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.453 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.453 | |
| 3o7b | SAH | Ribosomal RNA small subunit methyltransferase Nep1 | / | 0.453 | |
| 3tri | NAP | Pyrroline-5-carboxylate reductase | / | 0.453 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.453 | |
| 4ef8 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.453 | |
| 4feh | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.453 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.453 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.452 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.452 | |
| 1o0s | NAI | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.452 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 2p5c | SAH | Diphthine synthase | / | 0.452 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.452 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.452 | |
| 2xx9 | 1NF | Glutamate receptor 2 | / | 0.452 | |
| 3duy | AFJ | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.452 | |
| 3vx4 | ATP | Putative ABC transporter, ATP-binding protein ComA | / | 0.452 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.452 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.452 | |
| 4xb2 | NDP | 319aa long hypothetical homoserine dehydrogenase | / | 0.452 | |
| 5doz | NDP | JamJ | / | 0.452 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.451 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.451 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.451 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.451 | |
| 2eld | SAH | Diphthine synthase | / | 0.451 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.451 | |
| 2g20 | L1A | Renin | 3.4.23.15 | 0.451 | |
| 2ji6 | TPW | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.451 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.451 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.451 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.451 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.451 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.451 | |
| 5cyo | GDP | Septin-9 | / | 0.451 | |
| 1iy8 | NAD | Levodione reductase | / | 0.450 | |
| 2e16 | SAH | Diphthine synthase | / | 0.450 | |
| 2nni | MTK | Cytochrome P450 2C8 | / | 0.450 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.450 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.450 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.450 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.450 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.450 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.449 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.449 | |
| 1ikg | REX | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.449 | |
| 1s20 | NAD | 2,3-diketo-L-gulonate reductase | 1.1.1.130 | 0.449 | |
| 1tj1 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.449 | |
| 2djx | FMN | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.449 | |
| 2en5 | SAH | Diphthine synthase | / | 0.449 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.449 | |
| 2hrb | NAP | Carbonyl reductase [NADPH] 3 | 1.1.1.184 | 0.449 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.449 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.449 | |
| 3a3g | DLZ | Lumazine protein | / | 0.449 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.449 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.449 | |
| 4bam | MM9 | Prothrombin | 3.4.21.5 | 0.449 | |
| 4eke | D1I | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.449 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.449 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.449 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.449 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.449 | |
| 4i9n | 1E5 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.449 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.449 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.449 | |
| 4u0m | ATP | Cyclic GMP-AMP synthase | / | 0.449 | |
| 4up3 | FAD | Thioredoxin reductase | / | 0.449 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.448 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.448 | |
| 1w5s | ADP | ORC1-type DNA replication protein 2 | / | 0.448 | |
| 1wvg | APR | CDP-glucose 4,6-dehydratase | 4.2.1.45 | 0.448 | |
| 2a87 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.448 | |
| 2e15 | SAH | Diphthine synthase | / | 0.448 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.448 | |
| 2ii6 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.448 | |
| 2p2x | SAH | Diphthine synthase | / | 0.448 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.448 | |
| 3dg8 | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.448 | |
| 3gye | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.448 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.448 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.448 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.448 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.448 | |
| 3u9e | COA | Lmo1369 protein | / | 0.448 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.448 | |
| 4acx | S8Z | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.448 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.448 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4qen | SAH | Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 | 2.1.1.43 | 0.448 | |
| 5c41 | ACP | Ribokinase | / | 0.448 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.447 | |
| 2dv5 | SAH | Diphthine synthase | / | 0.447 | |
| 2dxx | SAH | Diphthine synthase | / | 0.447 | |
| 2emr | SAH | Diphthine synthase | / | 0.447 | |
| 2fgk | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.447 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.447 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.447 | |
| 2owf | SAH | Diphthine synthase | / | 0.447 | |
| 2qn7 | HBZ | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.447 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.447 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.447 | |
| 3h3f | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.447 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.447 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.447 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.447 | |
| 5cfl | C2E | Stimulator of interferon genes protein | / | 0.447 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.446 | |
| 1iqg | XME | Coagulation factor X | 3.4.21.6 | 0.446 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.446 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.446 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.446 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.446 | |
| 1vce | SAH | Diphthine synthase | / | 0.446 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.446 | |
| 1ywg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.446 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.446 | |
| 2ph6 | 712 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 2q85 | 973 | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.446 | |
| 3k8t | 2A5 | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.446 | |
| 4h3y | SAH | tRNA (guanine-N(1)-)-methyltransferase | / | 0.446 | |
| 4kgk | GTP | Uncharacterized protein | / | 0.446 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.446 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.446 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.446 | |
| 1k7f | IAV | Tryptophan synthase alpha chain | / | 0.445 | |
| 1l4g | NCN | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | 2.4.2.21 | 0.445 | |
| 1lrj | UD1 | UDP-glucose 4-epimerase | 5.1.3.2 | 0.445 | |
| 1wnt | NAP | L-xylulose reductase | 1.1.1.10 | 0.445 | |
| 1wzi | NDP | Malate dehydrogenase | / | 0.445 | |
| 2egs | SAH | Diphthine synthase | / | 0.445 | |
| 2ek7 | SAH | Diphthine synthase | / | 0.445 | |
| 2fb2 | SAM | GTP 3',8-cyclase | 4.1.99.18 | 0.445 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.445 | |
| 2j09 | FMN | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.445 | |
| 2qs4 | LY5 | Glutamate receptor ionotropic, kainate 1 | / | 0.445 | |
| 2vhq | ATP | NTPase P4 | / | 0.445 | |
| 2w02 | ATP | AcsD | / | 0.445 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.445 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.445 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.445 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.445 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.445 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.445 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.445 | |
| 3ojw | FMN | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.445 | |
| 3t14 | FAD | Sulfide-quinone reductase | / | 0.445 | |
| 3vye | VYE | Renin | 3.4.23.15 | 0.445 | |
| 3zhs | TD6 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.445 | |
| 4aa4 | QC0 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.445 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.445 | |
| 4xj4 | 3AT | Cyclic GMP-AMP synthase | / | 0.445 | |
| 4z4p | SAH | Histone-lysine N-methyltransferase 2D | 2.1.1.43 | 0.445 | |
| 5f8e | SAH | Possible transcriptional regulatory protein | / | 0.445 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.444 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.444 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1kqn | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.444 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.444 | |
| 1r2j | FAD | FkbI | / | 0.444 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.444 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.444 | |
| 2bfq | AR6 | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.444 | |
| 2bpo | NAP | NADPH--cytochrome P450 reductase | / | 0.444 | |
| 2e8r | SAH | Diphthine synthase | / | 0.444 | |
| 2ek4 | SAH | Diphthine synthase | / | 0.444 | |
| 2owk | SAH | Diphthine synthase | / | 0.444 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.444 | |
| 2qzl | IXS | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 2r8f | AGS | Non-structural protein 2 | 3.6.4 | 0.444 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.444 | |
| 2y4g | TIR | TamL | / | 0.444 | |
| 3bbr | BHY | Glutamate receptor 2 | / | 0.444 | |
| 3hl4 | CDC | Choline-phosphate cytidylyltransferase A | / | 0.444 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.444 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 4xcz | FON | Qdtf | / | 0.444 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1ohh | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.443 | |
| 1ohh | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.443 | |
| 1tj2 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.443 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.443 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.443 | |
| 2o12 | FMN | Chorismate synthase | / | 0.443 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.443 | |
| 2vzz | SCA | Putative succinyl-CoA transferase Rv0802c | 2.8.3 | 0.443 | |
| 3aw9 | GDU | NAD-dependent epimerase/dehydratase | / | 0.443 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.443 | |
| 3bbh | SFG | Ribosomal RNA small subunit methyltransferase Nep1 | 2.1.1 | 0.443 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.443 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.443 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.443 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.443 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.443 | |
| 3mvm | 39P | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3oix | FMN | Dihydroorotate dehydrogenase | / | 0.443 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.443 | |
| 3s87 | ADP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.443 | |
| 3suf | SUE | Polyprotein | / | 0.443 | |
| 3udq | 09E | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4b72 | 2FB | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.443 | |
| 4fdp | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.443 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4ig6 | SAH | tRNA (guanine-N(1)-)-methyltransferase | / | 0.443 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.443 | |
| 4kgm | ATP | Uncharacterized protein | / | 0.443 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.443 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1q6t | 600 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.442 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.442 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.442 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.442 | |
| 2e17 | SAH | Diphthine synthase | / | 0.442 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.442 | |
| 2ohv | NHL | Glutamate racemase | / | 0.442 | |
| 2owv | SAH | Diphthine synthase | / | 0.442 | |
| 2qtv | GNP | Small COPII coat GTPase SAR1 | 3.6.5 | 0.442 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.442 | |
| 2zgb | 21U | Prothrombin | 3.4.21.5 | 0.442 | |
| 3dm6 | 757 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.442 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.442 | |
| 4kwh | NAP | Reductase homolog | / | 0.442 | |
| 4lxb | 7R9 | Prothrombin | 3.4.21.5 | 0.442 | |
| 5dcy | NAP | Iridoid synthase | 1.3.1.99 | 0.442 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.442 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.441 | |
| 1ee9 | NAD | Methylenetetrahydrofolate dehydrogenase [NAD(+)] | 1.5.1.15 | 0.441 | |
| 1ezv | UQ6 | Cytochrome b | / | 0.441 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.441 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.441 | |
| 2d4v | NAD | Isocitrate dehydrogenase [NADP] | / | 0.441 | |
| 2djl | FMN | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.441 | |
| 2e4n | SAH | Diphthine synthase | / | 0.441 | |
| 2e7r | SAH | Diphthine synthase | / | 0.441 | |
| 2ejj | SAH | Diphthine synthase | / | 0.441 | |
| 2ekl | NAD | D-3-phosphoglycerate dehydrogenase | / | 0.441 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.441 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.441 | |
| 2gr1 | FAD | Ferredoxin reductase | / | 0.441 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2q0l | NAP | Thioredoxin reductase | 1.8.1.9 | 0.441 | |
| 2ql6 | ADP | Nicotinamide riboside kinase 1 | / | 0.441 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.441 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.441 | |
| 3d8b | ADP | Fidgetin-like protein 1 | 3.6.4 | 0.441 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.441 | |
| 3swq | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.441 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.441 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4gsu | DWZ | L,D-transpeptidase 2 | 2.3.2 | 0.441 | |
| 4jwj | SAH | tRNA (guanine(9)-N1)-methyltransferase | / | 0.441 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.441 | |
| 4loh | 1SY | Stimulator of interferon genes protein | / | 0.441 | |
| 4yvg | SAM | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.441 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.441 | |
| 1gq2 | NAP | NADP-dependent malic enzyme | 1.1.1.40 | 0.440 | |
| 1j21 | ATP | Argininosuccinate synthase | / | 0.440 | |
| 1l4l | NCN | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | 2.4.2.21 | 0.440 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.440 | |
| 1qy5 | NEC | Endoplasmin | / | 0.440 | |
| 1uxk | NAD | Malate dehydrogenase | / | 0.440 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.440 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.440 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.440 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 2el0 | SAH | Diphthine synthase | / | 0.440 | |
| 2fre | FMN | NAD(P)H-flavin oxidoreductase | / | 0.440 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.440 | |
| 2pb5 | SAH | Diphthine synthase | / | 0.440 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 3atr | FDA | Conserved Archaeal protein | / | 0.440 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.440 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.440 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.440 | |
| 3dm5 | GDP | Signal recognition particle 54 kDa protein | / | 0.440 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.440 | |
| 3i59 | N6R | CRP-like cAMP-activated global transcriptional regulator | / | 0.440 | |
| 3jzd | NAD | Maleylacetate reductase | / | 0.440 | |
| 3rn8 | RN8 | Glutamate receptor 2 | / | 0.440 | |
| 3ty3 | GGG | Homoisocitrate dehydrogenase | 1.1.1.87 | 0.440 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.440 | |
| 3vuc | HHE | Renin | 3.4.23.15 | 0.440 | |
| 3w2e | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.440 | |
| 4blr | UTP | NTPase P4 | / | 0.440 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.440 | |
| 4njv | RIT | Protease | / | 0.440 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.440 | |
| 4udr | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.440 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.440 | |
| 4yvj | SFG | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.440 | |
| 5dqr | FAD | 7-hydroxymethyl chlorophyll a reductase, chloroplastic | 1.17.7.2 | 0.440 |