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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2xnoED8Serine/threonine-protein kinase Nek22.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2xnoED8Serine/threonine-protein kinase Nek22.7.11.11.000
2xnmWGZSerine/threonine-protein kinase Nek22.7.11.10.664
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.660
2xnn430Serine/threonine-protein kinase Nek22.7.11.10.623
2xnpWCXSerine/threonine-protein kinase Nek22.7.11.10.611
2xk730ESerine/threonine-protein kinase Nek22.7.11.10.608
2xk6EQHSerine/threonine-protein kinase Nek22.7.11.10.601
2w5bAGSSerine/threonine-protein kinase Nek22.7.11.10.600
4afeGGYSerine/threonine-protein kinase Nek22.7.11.10.598
2xk4OL2Serine/threonine-protein kinase Nek22.7.11.10.593
2xkc4VQSerine/threonine-protein kinase Nek22.7.11.10.593
2xk85R1Serine/threonine-protein kinase Nek22.7.11.10.584
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.583
2jav5Z5Serine/threonine-protein kinase Nek22.7.11.10.573
4a4xJUPSerine/threonine-protein kinase Nek22.7.11.10.573
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.561
2xk3XK3Serine/threonine-protein kinase Nek22.7.11.10.556
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.554
2w5aADPSerine/threonine-protein kinase Nek22.7.11.10.548
2yac937Serine/threonine-protein kinase PLK12.7.11.210.543
2wqoVGKSerine/threonine-protein kinase Nek22.7.11.10.542
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.539
2owb626Serine/threonine-protein kinase PLK12.7.11.210.537
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.535
2a19ANPInterferon-induced, double-stranded RNA-activated protein kinase2.7.11.10.530
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.526
2in6839Wee1-like protein kinase2.7.10.20.524
3h4vDVPPteridine reductase 11.5.1.330.524
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.524
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.524
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.521
4b6l9ZPSerine/threonine-protein kinase PLK32.7.11.210.518
2z2w770Wee1-like protein kinase2.7.10.20.515
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.513
1blzACVIsopenicillin N synthase1.21.3.10.505
3p0fBAUUridine phosphorylase 22.4.2.30.505
2y60M8FIsopenicillin N synthase1.21.3.10.504
3cr0809Wee1-like protein kinase2.7.10.20.502
3zoiM2WIsopenicillin N synthase1.21.3.10.499
1x8b824Wee1-like protein kinase2.7.10.20.498
2bfpH4BPteridine reductase 11.5.1.330.495
3bi6396Wee1-like protein kinase2.7.10.20.494
1krv147Galactoside O-acetyltransferase2.3.1.180.493
2vbpVB1Isopenicillin N synthase1.21.3.10.493
3cqeP91Wee1-like protein kinase2.7.10.20.493
4h1j0YHProtein-tyrosine kinase 2-beta2.7.10.20.493
3zkyWT4Isopenicillin N synthase1.21.3.10.492
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.491
1d3dBZTProthrombin3.4.21.50.490
1qiqACCIsopenicillin N synthase1.21.3.10.490
2bf7HBIPteridine reductase 11.5.1.330.490
2x9vTMQPteridine reductase/0.490
1kuyCOTSerotonin N-acetyltransferase/0.489
3emlZMAAdenosine receptor A2a/0.489
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.487
2vcmM11Isopenicillin N synthase1.21.3.10.487
2bu9HFVIsopenicillin N synthase1.21.3.10.486
1hb3SCVIsopenicillin N synthase1.21.3.10.485
2bfaCB3Pteridine reductase 11.5.1.330.485
2jb4A14Isopenicillin N synthase1.21.3.10.485
3fzsB96Protein-tyrosine kinase 2-beta2.7.10.20.485
4f1mACPProbable serine/threonine-protein kinase roco42.7.11.10.485
1hb1OCVIsopenicillin N synthase1.21.3.10.484
3x04GNPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.484
1mj3HXCEnoyl-CoA hydratase, mitochondrial4.2.1.170.483
2y6fM9FIsopenicillin N synthase1.21.3.10.483
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.483
1nm6L86Prothrombin3.4.21.50.482
1qiwDPDCalmodulin/0.482
1qjfACSIsopenicillin N synthase1.21.3.10.482
2j9lATPH(+)/Cl(-) exchange transporter 5/0.482
4bb3KKAIsopenicillin N synthase1.21.3.10.482
1w06W05Isopenicillin N synthase1.21.3.10.481
2vczVC3Hematopoietic prostaglandin D synthase/0.480
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.480
1fm69CRRetinoic acid receptor RXR-alpha/0.479
1s3uTQDDihydrofolate reductase1.5.1.30.479
2iviACWIsopenicillin N synthase1.21.3.10.479
2w3aTOPDihydrofolate reductase1.5.1.30.479
4k9yK9YFocal adhesion kinase 12.7.10.20.479
1e92HBIPteridine reductase 11.5.1.330.478
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.478
3gncQQQGlutaryl-CoA dehydrogenase/0.478
3u8hBHPPhospholipase A2, membrane associated/0.478
1re0AFBADP-ribosylation factor 1/0.477
1re0AFBARF guanine-nucleotide exchange factor 1/0.477
2cn0F25Prothrombin3.4.21.50.477
3eigMTXDihydrofolate reductase1.5.1.30.477
3tfyCOAN-alpha-acetyltransferase 502.3.10.477
2qw8NAPEugenol synthase 11.1.1.3180.476
2zsdCOAPantothenate kinase2.7.1.330.476
3p2oNADBifunctional protein FolD/0.476
5dp2NAPCurF/0.476
1c4uIH1Prothrombin3.4.21.50.475
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.475
1aquESTEstrogen sulfotransferase, testis isoform2.8.2.40.474
1uwhBAXSerine/threonine-protein kinase B-raf2.7.11.10.474
1uzwCDHIsopenicillin N synthase1.21.3.10.474
3bloQEIQueuine tRNA-ribosyltransferase2.4.2.290.474
3gkjHC3Niemann-Pick C1 protein/0.474
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.474
5fm7ADPRuvB-like helicase/0.474
5iu86DZAdenosine receptor A2a/0.474
1bk0ACVIsopenicillin N synthase1.21.3.10.473
1lv89PPPurine nucleoside phosphorylase2.4.2.10.473
1u1d181Uridine phosphorylase2.4.2.30.473
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.473
2oh4GIGVascular endothelial growth factor receptor 22.7.10.10.473
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.473
2wo7ASVIsopenicillin N synthase1.21.3.10.473
3hf8ML0Tryptophan 5-hydroxylase 11.14.16.40.473
4bfvZVVPantothenate kinase2.7.1.330.473
2vcxD26Hematopoietic prostaglandin D synthase/0.472
2zfq45UProthrombin3.4.21.50.472
3ctj320Hepatocyte growth factor receptor2.7.10.10.472
3tubFPUTyrosine-protein kinase SYK2.7.10.20.472
4fal0T0Aldo-keto reductase family 1 member C3/0.472
4lv8ADPRhoptry protein 5 C/0.472
2ejzSAHDiphthine synthase/0.471
3b7dCNIGlutamate receptor 2/0.471
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.471
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
5uviZMAAdenosine receptor A2a/0.471
1obnASVIsopenicillin N synthase1.21.3.10.470
1odjGMPPurine nucleoside phosphorylase/0.470
1ozqPRFQueuine tRNA-ribosyltransferase2.4.2.290.470
1p33MTXPteridine reductase 11.5.1.330.470
1rd4L08Integrin alpha-L/0.470
3qbwADPAnhydro-N-acetylmuramic acid kinase/0.470
3qwc98PProthrombin3.4.21.50.470
3x025GPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.470
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.470
4fa30SLAldo-keto reductase family 1 member C3/0.470
2xncFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.469
3cth319Hepatocyte growth factor receptor2.7.10.10.469
3fkoFKOMitogen-activated protein kinase 14/0.469
3s41S41Glucokinase2.7.1.20.469
4at0FADPossible succinate dehydrogenase/0.469
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.469
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.469
1t57FMNConserved protein/0.468
2vbdV10Isopenicillin N synthase1.21.3.10.468
3gkiCLRNiemann-Pick C1 protein/0.468
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.468
4f1oACPProbable serine/threonine-protein kinase roco42.7.11.10.468
4li61XOTankyrase-12.4.2.300.468
1fmlRTLRetinol dehydratase/0.467
1k4gAIQQueuine tRNA-ribosyltransferase2.4.2.290.467
1mczRMNBenzoylformate decarboxylase4.1.1.70.467
1oc1ASVIsopenicillin N synthase1.21.3.10.467
1pd9CO4Dihydrofolate reductase1.5.1.30.467
1t9c1SMAcetolactate synthase catalytic subunit, mitochondrial2.2.1.60.467
1u1gBBBUridine phosphorylase2.4.2.30.467
2ed3SAHDiphthine synthase/0.467
3g0eB49Mast/stem cell growth factor receptor Kit2.7.10.10.467
3hfbML4Tryptophan 5-hydroxylase 11.14.16.40.467
1e7wMTXPteridine reductase 11.5.1.330.466
1u1f183Uridine phosphorylase2.4.2.30.466
2b35TCLEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.466
2cfcKPC2-(R)-hydroxypropyl-CoM dehydrogenase1.1.1.2680.466
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.466
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.466
4dhyS41Glucokinase2.7.1.20.466
4egnTWOCytochrome P450/0.466
4hfp15UProthrombin3.4.21.50.466
4hvs647Mast/stem cell growth factor receptor Kit2.7.10.10.466
5k2cZMAAdenosine receptor A2a/0.466
1jxzBCA4-chlorobenzoyl coenzyme A dehalogenase3.8.1.70.465
3dg8RJ6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.465
3njoPYVAbscisic acid receptor PYR1/0.465
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.465
4fewPP2Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.465
5bn4ANPV-type ATP synthase alpha chain/0.465
1d3pBT3Prothrombin3.4.21.50.464
1mapKETAspartate aminotransferase, mitochondrial2.6.1.10.464
1t13INI6,7-dimethyl-8-ribityllumazine synthase 2/0.464
2vz0D64Pteridine reductase/0.464
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.464
4b2gV1NUncharacterized protein/0.464
4l17DNQGlutamate receptor 2/0.464
4stdBFSScytalone dehydratase4.2.1.940.464
4twnB96Ephrin type-A receptor 32.7.10.10.464
1mu6CDAProthrombin3.4.21.50.463
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.463
2puiADPMethylthioribose kinase2.7.1.1000.463
2v3oI26Prothrombin3.4.21.50.463
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.463
3lm4HPXCatechol 2,3-dioxygenase/0.463
3x0a5GPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.463
4pl9ADPEthylene receptor 1/0.463
1diuBDMDihydrofolate reductase1.5.1.30.462
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
1ygkRRCPyridoxal kinase2.7.1.350.462
2hxdDUPdCTP deaminase, dUMP-forming3.5.4.300.462
2rgjFADFlavin-containing monooxygenase/0.462
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.462
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.462
4g95OAGDihydrofolate reductase1.5.1.30.462
4gg90WWQueuine tRNA-ribosyltransferase2.4.2.290.462
1dliUDXUDP-glucose 6-dehydrogenase/0.461
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.461
1rvvINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.461
2bo8GDXMannosylglycerate synthase/0.461
2fjm073Tyrosine-protein phosphatase non-receptor type 13.1.3.480.461
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.461
3n0yAPCAdenylate cyclase 2/0.461
3wv9FEGHmd co-occurring protein HcgE/0.461
3zkuHCVIsopenicillin N synthase1.21.3.10.461
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.461
1pt8ACOFormyl-CoA:oxalate CoA-transferase/0.460
3adaNADSubunit alpha of sarocosine oxidase/0.460
3fhxPXLPyridoxal kinase2.7.1.350.460
3gcq1BUMitogen-activated protein kinase 14/0.460
3q60ATPRhoptry protein 5B/0.460
4jbtASDCytochrome P450 monooxygenase/0.460
4pytFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.460
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
5k2aZMAAdenosine receptor A2a/0.460
1akbPPDAspartate aminotransferase, mitochondrial2.6.1.10.459
1nqxRLP6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.459
1uhhCZPAequorin-2/0.459
1wl4COAAcetyl-CoA acetyltransferase, cytosolic2.3.1.90.459
1yhjR6CPyridoxal kinase2.7.1.350.459
2ewaSB2Mitogen-activated protein kinase 14/0.459
2io6330Wee1-like protein kinase2.7.10.20.459
3iktNADRedox-sensing transcriptional repressor Rex/0.459
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.459
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.459
5jtbZMAAdenosine receptor A2a/0.459
3rfmCFFAdenosine receptor A2a/0.459
1drfFOLDihydrofolate reductase1.5.1.30.458
1dtpAPUDiphtheria toxin/0.458
1mvsDTMDihydrofolate reductase1.5.1.30.458
1xkqNDPUncharacterized protein/0.458
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
2a9z26AAdenosine kinase2.7.1.200.458
2zruFMNIsopentenyl-diphosphate delta-isomerase/0.458
4at4T6EBDNF/NT-3 growth factors receptor2.7.10.10.458
4b5oACOAlpha-tubulin N-acetyltransferase 1/0.458
4c717RD3-oxoacyl-ACP synthase/0.458
4dyp0MSNucleoprotein/0.458
4g1nNZTPyruvate kinase PKM2.7.1.400.458
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.458
4n3l2FNProthrombin3.4.21.50.458
1cqp803Integrin alpha-L/0.457
1pr4MTPPurine nucleoside phosphorylase DeoD-type/0.457
1rgsCMPcAMP-dependent protein kinase type I-alpha regulatory subunit/0.457
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.457
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.457
4eevL1XHepatocyte growth factor receptor2.7.10.10.457
4y7cFADNADPH--cytochrome P450 reductase/0.457
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.457
1ascNPLAspartate aminotransferase2.6.1.10.456
1pnqNDPNAD(P) transhydrogenase subunit beta1.6.1.20.456
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.456
1r8qAFBCytohesin-2/0.456
1r8qAFBADP-ribosylation factor 1/0.456
1rftPXMPyridoxal kinase2.7.1.350.456
1wuuANPGalactokinase2.7.1.60.456
1y5xE89Queuine tRNA-ribosyltransferase2.4.2.290.456
2ydoADNAdenosine receptor A2a/0.456
3dh7FMNIsopentenyl-diphosphate delta-isomerase/0.456
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
3q44D50M1 family aminopeptidase3.4.110.456
3tdkUPGUDP-glucose 6-dehydrogenase1.1.1.220.456
4fnyI3KALK tyrosine kinase receptor2.7.10.10.456
4kdrSAHUbiquinone biosynthesis O-methyltransferase/0.456
4p9dTMPDeoxycytidylate deaminase/0.456
5iu4ZMAAdenosine receptor A2a/0.456
5iua6DXAdenosine receptor A2a/0.456
3reyXACAdenosine receptor A2a/0.456
1n8wCOAMalate synthase G/0.455
1ne4RP1cAMP-dependent protein kinase type I-alpha regulatory subunit/0.455
2clfF6FTryptophan synthase alpha chain/0.455
2pksG44Prothrombin3.4.21.50.455
2z3uCRRCytochrome P450/0.455
3ewsADPATP-dependent RNA helicase DDX19B3.6.4.130.455
3i5xANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.455
3qm4PN0Cytochrome P450 2D6/0.455
3to3ATPPetrobactin biosynthesis protein AsbB/0.455
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.455
4da8BG2Purine nucleoside phosphorylase DeoD-type2.4.2.10.455
4iaq2GM5-hydroxytryptamine receptor 1B/0.455
5bn3ADPV-type ATP synthase alpha chain/0.455
5bn3ADPNEQ263/0.455
7catNDPCatalase1.11.1.60.455
1dhfFOLDihydrofolate reductase1.5.1.30.454
1h36R88Squalene--hopene cyclase4.2.1.1290.454
1ry0PG2Aldo-keto reductase family 1 member C3/0.454
1t9a1TBAcetolactate synthase catalytic subunit, mitochondrial2.2.1.60.454
1x8lOXRRetinol dehydratase/0.454
3ba6AN2Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.454
3iw8HIZMitogen-activated protein kinase 14/0.454
4kfj1R0Dihydrofolate reductase1.5.1.30.454
5g53NECAdenosine receptor A2a/0.454
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
1n5vNOMActVA 6 protein/0.453
1xlsREARetinoic acid receptor RXR-alpha/0.453
1xm1GAHProthrombin3.4.21.50.453
2cjfRP43-dehydroquinate dehydratase4.2.1.100.453
2gq3COAMalate synthase G/0.453
2ob0ACON-alpha-acetyltransferase 50/0.453
2w6oOA3Biotin carboxylase6.3.4.140.453
2zevIPEGeranylgeranyl pyrophosphate synthase/0.453
2zhq27UProthrombin3.4.21.50.453
3bxxQUEDihydroflavonol 4-reductase1.1.1.2190.453
3jq9AX1Pteridine reductase, putative/0.453
3tdaPN0Cytochrome P450 2D6/0.453
4djw0KPBeta-secretase 13.4.23.460.453
4fam0SZAldo-keto reductase family 1 member C3/0.453
4u163C0Muscarinic acetylcholine receptor M3/0.453
1disBDMDihydrofolate reductase1.5.1.30.452
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
1w87FADFerredoxin--NADP reductase1.18.1.20.452
1x2hLPALipoate-protein ligase A6.3.1.200.452
2anmCDOProthrombin3.4.21.50.452
2cf9348Prothrombin3.4.21.50.452
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase/0.452
2r2mI50Prothrombin3.4.21.50.452
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.452
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3ganSVRProtein RDM1/0.452
3jqgAX6Pteridine reductase, putative/0.452
3new3NEMitogen-activated protein kinase 14/0.452
3t5iSER_SER_CMT_FARRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.452
4ej1FOLDihydrofolate reductase1.5.1.30.452
4nmbFADBifunctional protein PutA/0.452
5iubCLRAdenosine receptor A2a/0.452
3uzaT4GAdenosine receptor A2a/0.452
1hfpMOTDihydrofolate reductase1.5.1.30.451
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
2bfmTOPPteridine reductase 11.5.1.330.451
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.451
2jedLG8Protein kinase C theta type2.7.11.130.451
2obxINI6,7-dimethyl-8-ribityllumazine synthase 22.5.1.780.451
2xtbKRMAdenosine kinase, putative/0.451
3ghvGHCDihydrofolate reductase1.5.1.30.451
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.451
3uq9TBNPutative adenosine kinase/0.451
3x03ANPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.451
4blcNDPCatalase1.11.1.60.451
4dymIYZActivin receptor type-12.7.11.300.451
1bucFADAcyl-CoA dehydrogenase, short-chain specific1.3.8.10.450
1k2sH4BNitric oxide synthase, brain1.14.13.390.450
1kruIPTGalactoside O-acetyltransferase2.3.1.180.450
1ypgUIRProthrombin3.4.21.50.450
2hr8SAHDiphthine synthase/0.450
2ojg19AMitogen-activated protein kinase 12.7.11.240.450
2p2xSAHDiphthine synthase/0.450
2yhuWHFPteridine reductase/0.450
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.450
3af1GDPPantothenate kinase2.7.1.330.450
3ebiBEYM1 family aminopeptidase3.4.110.450
3f0aACOSpermidine N(1)-acetyltransferase/0.450
3fznD7KBenzoylformate decarboxylase4.1.1.70.450
3ge7AFQQueuine tRNA-ribosyltransferase2.4.2.290.450
3jqbDX6Pteridine reductase, putative/0.450
3pn1IVHDNA ligase/0.450
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.450
4gs4ACOAlpha-tubulin N-acetyltransferase 1/0.450
4psbGA3Cytokinin-specific binding protein/0.450
4xbfFADLysine-specific histone demethylase 1A10.450
5stdUNNScytalone dehydratase4.2.1.940.450
1b87ACOAac(6')-Ii protein/0.449
1dr4HBIDihydrofolate reductase1.5.1.30.449
1k4hAPQQueuine tRNA-ribosyltransferase2.4.2.290.449
1ne6SP1cAMP-dependent protein kinase type I-alpha regulatory subunit/0.449
1s3vTQDDihydrofolate reductase1.5.1.30.449
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.449
2e7rSAHDiphthine synthase/0.449
2hldANPATP synthase subunit alpha, mitochondrial/0.449
2hldANPATP synthase subunit beta, mitochondrial3.6.3.140.449
2jh0701Prothrombin3.4.21.50.449
2z71PNVPenicillin acylase3.5.1.110.449
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.449
3cb2GDPTubulin gamma-1 chain/0.449
3fhxPLPPyridoxal kinase2.7.1.350.449
3htjETEbrA repressor/0.449
3vf60H6Glucokinase2.7.1.20.449
4gh30EVQueuine tRNA-ribosyltransferase2.4.2.290.449
4lwaQ13Nitric oxide synthase oxygenase1.14.13.1650.449
7stdCRPScytalone dehydratase4.2.1.940.449
1ivrCBAAspartate aminotransferase, mitochondrial2.6.1.10.448
1w19T4P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.448
1ypeUIPProthrombin3.4.21.50.448
2hxzH7JCathepsin S3.4.22.270.448
2zhe13UProthrombin3.4.21.50.448
3b4yF42F420-dependent glucose-6-phosphate dehydrogenase/0.448
3deiRXBCaspase-33.4.22.560.448
3hbfMYCFlavonoid 3-O-glucosyltransferase2.4.10.448
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.448
3nxyD2HDihydrofolate reductase1.5.1.30.448
4boeCLRJapanin/0.448
4plpNADHomospermidine synthase2.5.1.440.448
4xt8TMQPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc/0.448
4yerADPAntibiotic ABC transporter, ATP-binding protein, putative/0.448
5dstSAHProtein arginine N-methyltransferase 82.1.10.448
5k2dZMAAdenosine receptor A2a/0.448
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.447
1e2jTHMThymidine kinase/0.447
1pr6XYAPurine nucleoside phosphorylase DeoD-type/0.447
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.447
1xdsDRAAclacinomycin 10-hydroxylase RdmB4.1.10.447
2gevCOKPantothenate kinase2.7.1.330.447
2yg4FADPutrescine oxidase/0.447
3d5wADPSerine/threonine-protein kinase PLK/0.447
3d74NBBPheromone-binding protein ASP1/0.447
3eon341Glutaryl-CoA dehydrogenase/0.447
3fsjD7KBenzoylformate decarboxylase4.1.1.70.447
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
3nlqJRRNitric oxide synthase, brain1.14.13.390.447
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.447
3zc3FADFerredoxin--NADP reductase1.18.1.20.447
4a86H35Major pollen allergen Bet v 1-A/0.447
4b8mVX6Aurora kinase B-A2.7.11.10.447
4eqrCOACoenzyme A disulfide reductase/0.447
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.447
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.447
4h6zACOAlpha-tubulin N-acetyltransferase 1/0.447
4m8e29VRetinoic acid receptor RXR-alpha/0.447
4tyj0LIFibroblast growth factor receptor 42.7.10.10.447
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.447
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.446
1mvcBM6Retinoic acid receptor RXR-alpha/0.446
1mznBM6Retinoic acid receptor RXR-alpha/0.446
1pwyAC2Purine nucleoside phosphorylase2.4.2.10.446
1ygjRMCPyridoxal kinase2.7.1.350.446
2bjsACVIsopenicillin N synthase1.21.3.10.446
2e99B08Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.446
2ol4JPNEnoyl-ACP reductase/0.446
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
2r6jNDPEugenol synthase 11.1.1.3180.446
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
3ekuCY9Actin-5C/0.446
3k47D09Dihydrofolate reductase1.5.1.30.446
3llaACPMyosin heavy chain kinase A2.7.11.70.446
3n0hTOPDihydrofolate reductase1.5.1.30.446
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
4gh10WXQueuine tRNA-ribosyltransferase2.4.2.290.446
4hqvQEIQueuine tRNA-ribosyltransferase2.4.2.290.446
4jf1PLPAcetylornithine/succinyldiaminopimelate aminotransferase2.6.1.110.446
4omaLCSMethionine gamma-lyase/0.446
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.445
1o6rR19Squalene--hopene cyclase4.2.1.1290.445
2j4lUTPUridylate kinase2.7.4.220.445
2j83BATUlilysin3.4.240.445
2og81N8Tyrosine-protein kinase Lck2.7.10.20.445
2zrzFNRIsopentenyl-diphosphate delta-isomerase/0.445
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.445
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.445
4bqyFNTEgl nine homolog 1/0.445
4imuH4BNitric oxide synthase, brain1.14.13.390.445
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
1fr8GDUBeta-1,4-galactosyltransferase 1/0.444
1h60STRPentaerythritol tetranitrate reductase/0.444
1lcoPPYCytochrome b2, mitochondrial1.1.2.30.444
1ot7CHCBile acid receptor/0.444
1synF89Thymidylate synthase/0.444
1w19T5P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.444
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.444
2cdcNAPGlucose 1-dehydrogenase/0.444
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
3d76NBBPheromone-binding protein ASP1/0.444
3qe2FADNADPH--cytochrome P450 reductase/0.444
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.444
4dbw511Aldo-keto reductase family 1 member C3/0.444
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
4k5e1Q7Nitric oxide synthase, brain1.14.13.390.444
4l5b1UXDeoxycytidine kinase2.7.1.740.444
4phlPILPhosphodiesterase/0.444
4pnrG18Tankyrase-22.4.2.300.444
5je2SAHMethyl transferase/0.444
1a4wQWEProthrombin3.4.21.50.443
1jwtBLIProthrombin3.4.21.50.443
1mrqSTRAldo-keto reductase family 1 member C1/0.443
1nqvLMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.443
1o6qR17Squalene--hopene cyclase4.2.1.1290.443
1pkfEPDEpothilone C/D epoxidase1.140.443
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.443
1thnADPAnti-sigma F factor/0.443
1uhlMEIRetinoic acid receptor RXR-beta/0.443
1x1dSAHC-20 methyltransferase/0.443
1xu9CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.443
2cy2ACOProbable acetyltransferase/0.443
2e94364Geranylgeranyl pyrophosphate synthase/0.443
2gesCOKPantothenate kinase2.7.1.330.443
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
2p1t3TNRetinoic acid receptor RXR-alpha/0.443
3cgyRDCVirulence sensor histidine kinase PhoQ2.7.13.30.443
3cquCQURAC-alpha serine/threonine-protein kinase2.7.11.10.443
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
3hwxTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.443
3juqAKDPhenazine biosynthesis protein A/B/0.443
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.443
3p6oETGCamphor 5-monooxygenase1.14.15.10.443
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4a2aATPCell division protein FtsA/0.443
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.443
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.443
4c6zTLE3-oxoacyl-ACP synthase/0.443
4elb34SDihydrofolate reductase/0.443
4gtv7TRGeranylgeranyl transferase type-2 subunit beta2.5.1.600.443
4i8vBHFCytochrome P450 1A11.14.14.10.443
4kbn25UDihydrofolate reductase1.5.1.30.443
4nwiCTN7-methylguanosine phosphate-specific 5'-nucleotidase/0.443
1cq8PY6Aspartate aminotransferase2.6.1.10.442
1d4pBPPProthrombin3.4.21.50.442
1ej3CZHAequorin-2/0.442
1hfqMOTDihydrofolate reductase1.5.1.30.442
1k749CRRetinoic acid receptor RXR-alpha/0.442
1pq944BOxysterols receptor LXR-beta/0.442
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.442
2poqISDTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase1.3.1.200.442
2xiq5ADMethylmalonyl-CoA mutase, mitochondrial/0.442
3bjcWANcGMP-specific 3',5'-cyclic phosphodiesterase/0.442
3fvqATPFe(3+) ions import ATP-binding protein FbpC/0.442
3gxoMQAMitomycin biosynthesis 6-O-methyltransferase/0.442
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.442
3ix4TX1Transcriptional activator protein LasR/0.442
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.442
3oqkS52Renin3.4.23.150.442
3qfcFADNADPH--cytochrome P450 reductase/0.442
3rl35GPMetallophosphoesterase MPPED23.10.442
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
3zsh469Mitogen-activated protein kinase 14/0.442
4bfxZVXPantothenate kinase2.7.1.330.442
4ixc1JDGlucokinase2.7.1.20.442
4jln18VDeoxycytidine kinase2.7.1.740.442
4s1iPLPPyridoxal kinase, putative/0.442
4xymCOAAcyl-CoA synthetase (NDP forming)/0.442
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.442
5f54TMPSingle-stranded-DNA-specific exonuclease/0.442
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.442
5pahLDPPhenylalanine-4-hydroxylase1.14.16.10.442
1nzq162Prothrombin3.4.21.50.441
2lbdREARetinoic acid receptor gamma/0.441
2zhf49UProthrombin3.4.21.50.441
2zozETTranscriptional regulator/0.441
3br3ETHTH-type transcriptional regulator QacR/0.441
3c3xNAPEugenol synthase 11.1.1.3180.441
3d4bDZDNAD-dependent protein deacetylase/0.441
3h3t16HCollagen type IV alpha-3-binding protein/0.441
3pahXDEPhenylalanine-4-hydroxylase1.14.16.10.441
3rsv3RSBeta-secretase 13.4.23.460.441
3up0D7SaceDAF-12/0.441
3uvvREARetinoic acid receptor RXR-alpha/0.441
4ax9N5NProthrombin3.4.21.50.441
4equG6ISerine/threonine-protein kinase 102.7.11.10.441
4gvsF4MMethenyltetrahydromethanopterin cyclohydrolase3.5.4.270.441
4oeaDHTAndrogen receptor/0.441
4pahLNRPhenylalanine-4-hydroxylase1.14.16.10.441
4rh10TTSpore photoproduct lyase/0.441
4tl9AGSCircadian clock protein kinase KaiC2.7.11.10.441
4u0k744Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
5esdTDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.441
1a4iNDPC-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.440
1afeALZProthrombin3.4.21.50.440
1jtqLY3Thymidylate synthase/0.440
1qs2NADVip2Ac/0.440
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.440
1t4v14AProthrombin3.4.21.50.440
1v3q2DIPurine nucleoside phosphorylase2.4.2.10.440
1w83L11Mitogen-activated protein kinase 14/0.440
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
2e48FADD-amino-acid oxidase1.4.3.30.440
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
2vf0F89Thymidylate synthase/0.440
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.440
2zda32UProthrombin3.4.21.50.440
2zfr46UProthrombin3.4.21.50.440
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.440
3c1oNAPEugenol synthase/0.440
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.440
3p0eBAUUridine phosphorylase 22.4.2.30.440
3p3zP3ZPutative cytochrome P450/0.440
3pg3DG7Mitogen-activated protein kinase 14/0.440
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.440
3qdzPRO_ALA_PRO_ARGProthrombin3.4.21.50.440
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
4ap1NAPSteroid monooxygenase/0.440
4da6GA2Purine nucleoside phosphorylase DeoD-type2.4.2.10.440
4e2yJHZMethyltransferase/0.440
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
4ixd1HVIntegrin alpha-L/0.440
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.440
5ej7TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.440
6stdMS2Scytalone dehydratase4.2.1.940.440