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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4cb741GPolymerase basic protein 2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4cb741GPolymerase basic protein 2/1.000
4eqkMGTPolymerase basic protein 2/0.602
4nceMGTPolymerase basic protein 2/0.578
5fmmMGTPolymerase basic protein 2/0.566
4cb593GPolymerase basic protein 2/0.559
4cb4MGTPolymerase basic protein 2/0.534
4cb629RPolymerase basic protein 2/0.531
1w6jR71Lanosterol synthase5.4.99.70.525
4bfwZVWPantothenate kinase2.7.1.330.525
1votHUPAcetylcholinesterase3.1.1.70.521
2vqzMGTPolymerase basic protein 2/0.519
2ha6SCKAcetylcholinesterase3.1.1.70.514
1b2lNDCAlcohol dehydrogenase1.1.1.10.509
2cekN8TAcetylcholinesterase3.1.1.70.506
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.506
1d3dBZTProthrombin3.4.21.50.504
1gpnHUBAcetylcholinesterase3.1.1.70.504
1w6rGNTAcetylcholinesterase3.1.1.70.504
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.503
1odcA8BAcetylcholinesterase3.1.1.70.502
4bfxZVXPantothenate kinase2.7.1.330.502
1h66RH1NAD(P)H dehydrogenase [quinone] 11.6.5.20.501
2o6hINI6,7-dimethyl-8-ribityllumazine synthase 12.5.1.780.501
1u65CP0Acetylcholinesterase3.1.1.70.500
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.500
4n9qFMNFMN-dependent NADH-azoreductase 1/0.499
3dr7GPDGDP-perosamine synthase/0.497
1s1rNAPAldo-keto reductase family 1 member C3/0.495
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.493
4es5MGTPolymerase basic protein 2/0.491
1enoNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.490
1zgbA1EAcetylcholinesterase3.1.1.70.490
4bftZVTPantothenate kinase2.7.1.330.490
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.489
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.489
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.488
4xbjIN5Alanine racemase, biosynthetic/0.488
2futH1SHeparin and heparin-sulfate lyase/0.487
3dhk23UProthrombin3.4.21.50.487
4b65NDPL-ornithine N(5)-monooxygenase/0.487
4n3l2FNProthrombin3.4.21.50.487
3af0GDPPantothenate kinase2.7.1.330.486
1rxjBNIStreptavidin/0.485
3zv7NHGAcetylcholinesterase3.1.1.70.485
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.484
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.484
4a86H35Major pollen allergen Bet v 1-A/0.484
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.483
2ckmAA7Acetylcholinesterase3.1.1.70.483
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.483
4nv10FXFormyl transferase/0.483
2qimZEAClass 10 plant pathogenesis-related protein/0.482
4bz8J38Histone deacetylase/0.481
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.481
1q84TZ4Acetylcholinesterase3.1.1.70.480
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.480
2anmCDOProthrombin3.4.21.50.480
2g0bNLTLong-chain N-acyl amino acid synthase/0.480
3uyk0CXProbable NDP-rhamnosyltransferase/0.480
1yw8A75Methionine aminopeptidase 2/0.479
2whqHI6Acetylcholinesterase3.1.1.70.479
3bjcWANcGMP-specific 3',5'-cyclic phosphodiesterase/0.479
3h3qH13Collagen type IV alpha-3-binding protein/0.479
3h3r14HCollagen type IV alpha-3-binding protein/0.479
4bfvZVVPantothenate kinase2.7.1.330.479
1pwyAC2Purine nucleoside phosphorylase2.4.2.10.478
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.478
2zi224UProthrombin3.4.21.50.477
3ziuLSSLeucyl-tRNA synthetase/0.477
4b68FADL-ornithine N(5)-monooxygenase/0.477
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.476
1vkgCRIHistone deacetylase 83.5.1.980.476
1yplRA8Prothrombin3.4.21.50.475
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.475
2ojg19AMitogen-activated protein kinase 12.7.11.240.475
2xjeU5PCytosolic purine 5'-nucleotidase3.1.3.50.475
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.475
3ggs2FDPurine nucleoside phosphorylase2.4.2.10.475
3zj7C1KStrictosidine-O-beta-D-glucosidase3.2.1.1050.475
4mrm2BYGamma-aminobutyric acid type B receptor subunit 1/0.475
4wx2F6FTryptophan synthase alpha chain/0.475
4wx2F6FTryptophan synthase beta chain4.2.1.200.475
1n0sFLUBilin-binding protein/0.474
2r2mI50Prothrombin3.4.21.50.474
2rc6FADFerredoxin--NADP reductase/0.474
2xi4AFTAcetylcholinesterase3.1.1.70.474
2xuoTZ4Acetylcholinesterase3.1.1.70.474
2zf051UProthrombin3.4.21.50.474
3af1GDPPantothenate kinase2.7.1.330.474
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.474
4bfzZVZPantothenate kinase2.7.1.330.474
2xuhTZ4Acetylcholinesterase3.1.1.70.473
4a16H34Acetylcholinesterase3.1.1.70.473
4m0e1YLAcetylcholinesterase3.1.1.70.473
1x2eATXProline iminopeptidase3.4.11.50.472
2zhw12UProthrombin3.4.21.50.472
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.472
4bqwQNMEgl nine homolog 1/0.472
5ah5LSSLeucine--tRNA ligase/0.472
1c4uIH1Prothrombin3.4.21.50.471
1e66HUXAcetylcholinesterase3.1.1.70.471
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.471
3h3t16HCollagen type IV alpha-3-binding protein/0.471
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.471
4a87NARMajor pollen allergen Bet v 1-A/0.471
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.471
1z71L17Prothrombin3.4.21.50.470
2hdjNDPAldo-keto reductase family 1 member C2/0.470
2ixkTDOdTDP-4-dehydrorhamnose 3,5-epimerase5.1.3.130.470
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.470
2zc922UProthrombin3.4.21.50.470
3biu10UProthrombin3.4.21.50.470
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.470
1dx6GNTAcetylcholinesterase3.1.1.70.469
1ut6A8NAcetylcholinesterase3.1.1.70.469
2vkeTACTetracycline repressor protein class D/0.469
2xujTZ5Acetylcholinesterase3.1.1.70.469
3irhDTPHD domain protein/0.469
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.469
1k4mNADNicotinate-nucleotide adenylyltransferase2.7.7.180.468
1zgcA2EAcetylcholinesterase3.1.1.70.468
2bd0BIOSepiapterin reductase/0.468
3f3y4OABile salt sulfotransferase2.8.2.140.468
3s8pSAMHistone-lysine N-methyltransferase KMT5B2.1.1.430.468
3wqmB29Diterpene synthase3.1.7.80.468
4ey7E20Acetylcholinesterase3.1.1.70.468
4ts7ADPPurine phosphoribosyltransferase (GpT-1)/0.468
2cmfF11Acetylcholinesterase3.1.1.70.467
3dzjNMNADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.467
3sqxANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.467
5dp2NAPCurF/0.467
1c3rTSNAcetoin utilization protein/0.466
1lnmDTXBilin-binding protein/0.466
1qtiGNTAcetylcholinesterase3.1.1.70.466
2gz7D3FOrf1a polyprotein/0.466
4a1oAMZBifunctional purine biosynthesis protein PurH2.1.2.30.466
4kfqKFQGlutamate receptor ionotropic, NMDA 1/0.466
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.465
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.465
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.465
1krrACOGalactoside O-acetyltransferase2.3.1.180.465
1w4lGL8Acetylcholinesterase3.1.1.70.465
1w76GNTAcetylcholinesterase3.1.1.70.465
2xlpNAPPutative flavin-containing monooxygenase/0.465
2xysSY9Soluble acetylcholine receptor/0.465
2zgb21UProthrombin3.4.21.50.465
2zgx29UProthrombin3.4.21.50.465
3c1kT15Prothrombin3.4.21.50.465
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.465
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.465
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.465
3w5hFADNADH-cytochrome b5 reductase 31.6.2.20.465
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.465
4q0kGA3Phytohormone-binding protein/0.465
1rftPXMPyridoxal kinase2.7.1.350.464
2jl1NAPTriphenylmethane reductase/0.464
4ey6GNTAcetylcholinesterase3.1.1.70.464
4qfxDGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.464
4xo7ASDAldo-keto reductase family 1 member C2/0.464
1h35R01Squalene--hopene cyclase4.2.1.1290.463
2jh5895Prothrombin3.4.21.50.463
2pbzATPUncharacterized protein/0.463
2vz0D64Pteridine reductase/0.463
2zhe13UProthrombin3.4.21.50.463
4b7zQ4QAcetylcholinesterase3.1.1.70.463
4bamMM9Prothrombin3.4.21.50.463
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.463
4j7gTRHPCZA361.3/0.463
4ld2CTNCytidine and deoxycytidylate deaminase zinc-binding region/0.463
4rn615UProthrombin3.4.21.50.463
1culFOKAdenylate cyclase type 2/0.462
1culFOKAdenylate cyclase type 5/0.462
1hfqMOTDihydrofolate reductase1.5.1.30.462
1mxfMTXPutative pteridine reductase 2/0.462
1ypeUIPProthrombin3.4.21.50.462
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.462
3ojwFMNNADPH--cytochrome P450 reductase/0.462
4b1jA1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.462
4u140HKMuscarinic acetylcholine receptor M3/0.462
2cbrA80Cellular retinoic acid-binding protein 1/0.461
2ea2F77Methionine aminopeptidase 2/0.461
2ga2A19Methionine aminopeptidase 2/0.461
2j3qTFLAcetylcholinesterase3.1.1.70.461
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.461
3vilSA0Beta-glucosidase/0.461
4a81DXCMajor pollen allergen Bet v 1-A/0.461
1go2FADFerredoxin--NADP reductase1.18.1.20.460
1obnASVIsopenicillin N synthase1.21.3.10.460
1t4v14AProthrombin3.4.21.50.460
1xmmM7Gm7GpppX diphosphatase3.6.1.590.460
2i65NADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.460
2qe2452Polyprotein/0.460
2xltNA0Putative flavin-containing monooxygenase/0.460
2xq0BESLeukotriene A-4 hydrolase homolog3.3.2.60.460
2xupTZ5Acetylcholinesterase3.1.1.70.460
2zfr46UProthrombin3.4.21.50.460
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.460
3ai0PNWBeta-glucosidase/0.460
3e6eDCSAlanine racemase/0.460
3fhxPXLPyridoxal kinase2.7.1.350.460
3jq7DX2Pteridine reductase, putative/0.460
3mauEXTPutative sphingosine-1-phosphate lyase/0.460
4bfuZVUPantothenate kinase2.7.1.330.460
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
4f0rMTA5-methylthioadenosine/S-adenosylhomocysteine deaminase/0.460
4gv8DUPDUTPase/0.460
4jtqFLPAldo-keto reductase family 1 member C2/0.460
4l6s1WQPoly [ADP-ribose] polymerase 12.4.2.300.460
1lgtBP3Biphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.459
1p0pBCHCholinesterase3.1.1.80.459
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
2gevCOKPantothenate kinase2.7.1.330.459
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.459
2vq7NAPPutative flavin-containing monooxygenase/0.459
2wu4HBPAcetylcholinesterase3.1.1.70.459
3gncQQQGlutaryl-CoA dehydrogenase/0.459
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.459
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.459
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.459
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.459
1c4vIH2Prothrombin3.4.21.50.458
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.458
1jqdSAHHistamine N-methyltransferase2.1.1.80.458
1lkeDOGBilin-binding protein/0.458
1ta6177Prothrombin3.4.21.50.458
2xvhNAPPutative flavin-containing monooxygenase/0.458
2zff53UProthrombin3.4.21.50.458
3dv0TPWPyruvate dehydrogenase E1 component subunit alpha1.2.4.10.458
3dv0TPWPyruvate dehydrogenase E1 component subunit beta1.2.4.10.458
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
3fazNOSPurine nucleoside phosphorylase/0.458
3kkzSAMUncharacterized protein/0.458
4b67NAPL-ornithine N(5)-monooxygenase/0.458
4ge90L0Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.458
1kyyINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.457
1wkgPOI[LysW]-aminoadipate semialdehyde transaminase/0.457
2aj4ANPGalactokinase2.7.1.60.457
2uxoTACHTH-type transcriptional regulator TtgR/0.457
3zoiM2WIsopenicillin N synthase1.21.3.10.457
4b64NAPL-ornithine N(5)-monooxygenase/0.457
4bqzGNPEctonucleoside triphosphate diphosphohydrolase 2/0.457
4jtrIZPAldo-keto reductase family 1 member C2/0.457
4wljIK2Kynurenine--oxoglutarate transaminase 12.6.1.70.457
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
1ypjUIBProthrombin3.4.21.50.456
2cleF6FTryptophan synthase alpha chain/0.456
2fhjH4ZFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.456
2pb1NFGGlucan 1,3-beta-glucosidase/0.456
2xuqTZ4Acetylcholinesterase3.1.1.70.456
2zhf49UProthrombin3.4.21.50.456
2zrzFNRIsopentenyl-diphosphate delta-isomerase/0.456
3elePLPAminotransferase/0.456
3fhxPLPPyridoxal kinase2.7.1.350.456
3g0yP9A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.456
3lzzGDPUncharacterized protein/0.456
3qeoLLTDeoxycytidine kinase2.7.1.740.456
4bfsZVSPantothenate kinase2.7.1.330.456
5ctoNTD4-hydroxyphenylpyruvate dioxygenase1.13.11.270.456
1oytFSNProthrombin3.4.21.50.455
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.455
2gyuHI6Acetylcholinesterase3.1.1.70.455
2jb4A14Isopenicillin N synthase1.21.3.10.455
2zg050UProthrombin3.4.21.50.455
3qftFADNADPH--cytochrome P450 reductase/0.455
1h22E10Acetylcholinesterase3.1.1.70.454
1yqzCOACoenzyme A disulfide reductase/0.454
2b58COADiamine acetyltransferase 1/0.454
3e4aQIXInsulin-degrading enzyme3.4.24.560.454
3iu9T07Methionine aminopeptidase 2/0.454
3uzxAOM3-oxo-5-beta-steroid 4-dehydrogenase/0.454
4fhf0TTSpore photoproduct lyase/0.454
1cjvFOKAdenylate cyclase type 2/0.453
1cjvFOKAdenylate cyclase type 5/0.453
1mueCDDProthrombin3.4.21.50.453
1queFADFerredoxin--NADP reductase1.18.1.20.453
1ro98BRcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.453
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.453
2cf9348Prothrombin3.4.21.50.453
2gdeSN3Prothrombin3.4.21.50.453
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.453
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.453
2pucGUNHTH-type transcriptional repressor PurR/0.453
2xuiTZ5Acetylcholinesterase3.1.1.70.453
3d4bDZDNAD-dependent protein deacetylase/0.453
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.453
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.453
3nytULPUDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.453
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
4jq4IMNAldo-keto reductase family 1 member C2/0.453
4rp8ASCAscorbate-specific PTS system EIIC component/0.453
1rkwPNTHTH-type transcriptional regulator QacR/0.452
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.452
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
2a9y26AAdenosine kinase2.7.1.200.452
2vcmM11Isopenicillin N synthase1.21.3.10.452
2w6cBM4Acetylcholinesterase3.1.1.70.452
3c15FOKAdenylate cyclase type 2/0.452
3c15FOKAdenylate cyclase type 5/0.452
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3oikWZBCarbonic anhydrase 24.2.1.10.452
4araC56Acetylcholinesterase3.1.1.70.452
4hcy0YNTransketolase/0.452
1dqaCOA3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.451
1e64FADFerredoxin--NADP reductase1.18.1.20.451
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.451
1xk9P34Exotoxin A2.4.2.360.451
1xm1GAHProthrombin3.4.21.50.451
2r0pK2CPutative FAD-monooxygenase/0.451
2uuk897Prothrombin3.4.21.50.451
2v58LZJBiotin carboxylase6.3.4.140.451
2zdv37UProthrombin3.4.21.50.451
2ziq26UProthrombin3.4.21.50.451
3arvSAUChitinase A/0.451
3eq02TSProthrombin3.4.21.50.451
3jq6DX1Pteridine reductase, putative/0.451
3nny59RNitric oxide synthase, brain1.14.13.390.451
3ocw3AMLipoprotein E/0.451
3pm1ETHTH-type transcriptional regulator QacR/0.451
3rl45GPMetallophosphoesterase MPPED23.10.451
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.451
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.451
4nwiCTN7-methylguanosine phosphate-specific 5'-nucleotidase/0.451
4phlPILPhosphodiesterase/0.451
4zowCLMMultidrug transporter MdfA/0.451
5choFADFlavin reductase/0.451
1afeALZProthrombin3.4.21.50.450
1ry0PG2Aldo-keto reductase family 1 member C3/0.450
1x8lOXRRetinol dehydratase/0.450
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.450
2j7cIDEBeta-glucosidase A3.2.1.210.450
2rd2QSIGlutamine--tRNA ligase6.1.1.180.450
2v3hI25Prothrombin3.4.21.50.450
2v57PRLTetR family transcriptional regulator/0.450
2xytTC9Soluble acetylcholine receptor/0.450
3biv11UProthrombin3.4.21.50.450
3nxrD2DDihydrofolate reductase1.5.1.30.450
3zhvTDWMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.450
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.450
4g8jTHMUridine phosphorylase/0.450
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.450
1jnrFADAdenylylsulfate reductase, subunit A (AprA)/0.449
1nm6L86Prothrombin3.4.21.50.449
1o1t2NHProtein farnesyltransferase subunit beta2.5.1.580.449
1s2cFLFAldo-keto reductase family 1 member C3/0.449
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2a9z26AAdenosine kinase2.7.1.200.449
2gfxPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.449
2hxdDUPdCTP deaminase, dUMP-forming3.5.4.300.449
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.449
2yp0OVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.449
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.449
3fapARDSerine/threonine-protein kinase mTOR2.7.11.10.449
3hl0NADMaleylacetate reductase/0.449
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
4mlp2CXCryptochrome-2/0.449
4mr72BVGamma-aminobutyric acid type B receptor subunit 1/0.449
4tnzTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.449
4to1DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.449
5c1gGDUHisto-blood group ABO system transferase/0.449
1cjtFOKAdenylate cyclase type 2/0.448
1cjtFOKAdenylate cyclase type 5/0.448
1d4pBPPProthrombin3.4.21.50.448
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.448
1t4u81AProthrombin3.4.21.50.448
2a2xNA9Prothrombin3.4.21.50.448
2iviACWIsopenicillin N synthase1.21.3.10.448
2pdaTPPPyruvate synthase/0.448
2xukTZ5Acetylcholinesterase3.1.1.70.448
3akzGSUGlutamate--tRNA ligase 2/0.448
3b4p3B4Phenazine biosynthesis protein A/B/0.448
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.448
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.448
3g5mFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.448
3hxdBD7Geranylgeranyl transferase type-2 subunit beta2.5.1.600.448
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3uaxNOSPurine nucleoside phosphorylase DeoD-type/0.448
3zj6VM2Raucaffricine-O-beta-D-glucosidase3.2.1.1250.448
4ax9N5NProthrombin3.4.21.50.448
4bahMELProthrombin3.4.21.50.448
4dxlC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.448
4fam0SZAldo-keto reductase family 1 member C3/0.448
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.448
4jbsP52Endoplasmic reticulum aminopeptidase 23.4.110.448
4qoeFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.448
3uonQNBMuscarinic acetylcholine receptor M2/0.448
1c9wNAPAldose reductase-related protein 2/0.447
1d6w00RProthrombin3.4.21.50.447
1ja0FADNADPH--cytochrome P450 reductase/0.447
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.447
1n5vNOMActVA 6 protein/0.447
1thnADPAnti-sigma F factor/0.447
1ve3SAMUncharacterized protein/0.447
1zisINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.447
2c42TPPPyruvate synthase/0.447
2ea4F79Methionine aminopeptidase 2/0.447
2gvdFKPAdenylate cyclase type 2/0.447
2gvdFKPAdenylate cyclase type 5/0.447
2x7hPFNProstaglandin reductase 310.447
2y60M8FIsopenicillin N synthase1.21.3.10.447
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3qdzPRO_ALA_PRO_ARGProthrombin3.4.21.50.447
3uzzASD3-oxo-5-beta-steroid 4-dehydrogenase/0.447
4b5oACOAlpha-tubulin N-acetyltransferase 1/0.447
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.447
4itxIN5Cystathionine beta-lyase MetC4.4.1.80.447
4j7hTRHPCZA361.3/0.447
4l4v1VYMajor histocompatibility complex class I-related gene protein/0.447
5dsg0HKMuscarinic acetylcholine receptor M4/0.447
4u150HKMuscarinic acetylcholine receptor M3/0.447
1ahgTYR_PLPAspartate aminotransferase2.6.1.10.446
1eouSMSCarbonic anhydrase 24.2.1.10.446
1eveE20Acetylcholinesterase3.1.1.70.446
1ex75GPGuanylate kinase2.7.4.80.446
1j8qFMNFlavodoxin/0.446
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.446
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
2ed4NAD4-hydroxyphenylacetate 3-monooxygenase reductase component1.5.1.360.446
2hp2KE4Glutamate-1-semialdehyde 2,1-aminomutase5.4.3.80.446
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
2zda32UProthrombin3.4.21.50.446
2zhq27UProthrombin3.4.21.50.446
2znk31UProthrombin3.4.21.50.446
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.446
3v0p4GWHisto-blood group ABO system transferase/0.446
4b66NAPL-ornithine N(5)-monooxygenase/0.446
4du6GTPGTP cyclohydrolase 1/0.446
4eqrCOACoenzyme A disulfide reductase/0.446
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.446
4xo7NAPAldo-keto reductase family 1 member C2/0.446
1fmlRTLRetinol dehydratase/0.445
1hb3SCVIsopenicillin N synthase1.21.3.10.445
1oxoIK2Aspartate aminotransferase, mitochondrial2.6.1.10.445
1w19T5P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.445
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
2a1hGBNBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.445
2bn4FMNNADPH--cytochrome P450 reductase/0.445
2e94364Geranylgeranyl pyrophosphate synthase/0.445
2po7CHDFerrochelatase, mitochondrial4.99.1.10.445
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.445
2wo7ASVIsopenicillin N synthase1.21.3.10.445
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.445
3fznD7KBenzoylformate decarboxylase4.1.1.70.445
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.445
4mm729JNa(+):neurotransmitter symporter (Snf family)/0.445
4yfy0FXVioF/0.445
1g63FMNEpidermin decarboxylase4.1.10.444
1kekHTLPyruvate synthase/0.444
1sb1165Prothrombin3.4.21.50.444
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.444
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
1yw7A41Methionine aminopeptidase 2/0.444
2aovC2MHistamine N-methyltransferase2.1.1.80.444
2bf7HBIPteridine reductase 11.5.1.330.444
2gv8NDPThiol-specific monooxygenase1.14.130.444
2jgsBTNAvidin/0.444
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.444
3c27DKKProthrombin3.4.21.50.444
3dr4G4MGDP-perosamine synthase/0.444
3g0bT22Dipeptidyl peptidase 4/0.444
3gwfFADCyclohexanone monooxygenase/0.444
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.600.444
4b4vL34Bifunctional protein FolD/0.444
4bfyZVYPantothenate kinase2.7.1.330.444
4dz7D02Carbonic anhydrase 24.2.1.10.444
4rxsTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.444
4xwtU5PRibonuclease J/0.444
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.443
1dgfNDPCatalase1.11.1.60.443
1digL37C-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.443
1dmwHBIPhenylalanine-4-hydroxylase1.14.16.10.443
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.443
2v5uFMNFlavodoxin/0.443
2vrjNCWBeta-glucosidase A3.2.1.210.443
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.443
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.443
3cv6HXSAldo-keto reductase family 1 member C21/0.443
3fpkFADFerredoxin-NADP reductase/0.443
3w5uFADFerredoxin/0.443
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.443
4e2yJHZMethyltransferase/0.443
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4usrFADMonooxygenase/0.443
4uugPXGBranched-chain amino acid aminotransferase, putative/0.443
5c1mCLRMu-type opioid receptor/0.443
5f54TMPSingle-stranded-DNA-specific exonuclease/0.443
1a9p9DIPurine nucleoside phosphorylase2.4.2.10.442
1amoFMNNADPH--cytochrome P450 reductase/0.442
1g60SAMModification methylase MboII2.1.1.720.442
1ihiIU5Aldo-keto reductase family 1 member C2/0.442
1pq944BOxysterols receptor LXR-beta/0.442
1tllFMNNitric oxide synthase, brain1.14.13.390.442
2a0xDIHPurine nucleoside phosphorylase2.4.2.10.442
2dg3RAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.442
2jh6894Prothrombin3.4.21.50.442
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.442
2ok7A2PFerredoxin--NADP reductase, apicoplast/0.442
2xnvVU3Soluble acetylcholine receptor/0.442
3anlSYC1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.442
3h1vTK1Glucokinase2.7.1.20.442
4e32DWNMethyltransferase/0.442
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
1h69ARHNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1m4dCOAAminoglycoside 2'-N-acetyltransferase2.3.10.441
1vzqSHYProthrombin3.4.21.50.441
1yw9A84Methionine aminopeptidase 2/0.441
1zgi382Prothrombin3.4.21.50.441
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.441
2wnbC5PCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 12.4.99.40.441
2xegCI9Glutamate carboxypeptidase 23.4.17.210.441
2y6fM9FIsopenicillin N synthase1.21.3.10.441
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3dd0EZLCarbonic anhydrase 24.2.1.10.441
3dhaC6LN-acyl homoserine lactonase AiiA3.1.1.810.441
3e4vFMNUncharacterized protein/0.441
3ho9N3A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.441
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4bupSAMHistone-lysine N-methyltransferase KMT5B2.1.1.430.441
4c717RD3-oxoacyl-ACP synthase/0.441
4dbuBT9Aldo-keto reductase family 1 member C3/0.441
4fizCUE17beta-hydroxysteroid dehydrogenase/0.441
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
5a4wQCTGlutathione S-transferase F22.5.1.180.441
1ktsC24Prothrombin3.4.21.50.440
1m51TSXPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.440
1p33MTXPteridine reductase 11.5.1.330.440
1rkpIBMcGMP-specific 3',5'-cyclic phosphodiesterase/0.440
1s7gNADNAD-dependent protein deacylase 2/0.440
1tu8GTXGlutathione S-transferase 22.5.1.180.440
1zdwFLVPrenyltransferase/0.440
2c9bPUG6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
2uuoLK3UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.440
3br3ETHTH-type transcriptional regulator QacR/0.440
3c0zSHHHistone deacetylase 73.5.1.980.440
3cb2GDPTubulin gamma-1 chain/0.440
3ce0P34Poly [ADP-ribose] polymerase 32.4.2.300.440
3gf4U5PUDP-galactopyranose mutase5.4.99.90.440
3h3sH15Collagen type IV alpha-3-binding protein/0.440
3ju8NADN-succinylglutamate 5-semialdehyde dehydrogenase1.2.1.710.440
3lm1LECAgglutinin alpha chain/0.440
4h6zACOAlpha-tubulin N-acetyltransferase 1/0.440
4ieiADPGene 2 protein/0.440
4jzr4JREgl nine homolog 1/0.440
4l1xNAPAldo-keto reductase family 1 member C2/0.440
4oex5EOcGMP-specific 3',5'-cyclic phosphodiesterase/0.440
4to4DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.440
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.440
5irnADPNucleotide binding oligomerization domain containing 2/0.440