sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2xdr | NDP | NAD/NADP-dependent betaine aldehyde dehydrogenase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2xdr | NDP | NAD/NADP-dependent betaine aldehyde dehydrogenase | / | 1.000 | |
| 3zqa | NDP | NAD/NADP-dependent betaine aldehyde dehydrogenase | / | 0.633 | |
| 2wme | NAP | NAD/NADP-dependent betaine aldehyde dehydrogenase | / | 0.626 | |
| 3ju8 | NAD | N-succinylglutamate 5-semialdehyde dehydrogenase | 1.2.1.71 | 0.523 | |
| 3iwk | NAD | Aminoaldehyde dehydrogenase | / | 0.515 | |
| 4nmk | NAP | Aldehyde dehydrogenase | / | 0.514 | |
| 4i1w | NAD | 2-aminomuconate 6-semialdehyde dehydrogenase | / | 0.512 | |
| 1bpw | NAD | Betaine aldehyde dehydrogenase | 1.2.1.8 | 0.504 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.488 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.488 | |
| 4phl | PIL | Phosphodiesterase | / | 0.488 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.487 | |
| 4a0m | NAD | Betaine aldehyde dehydrogenase, chloroplastic | 1.2.1.8 | 0.487 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.485 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.484 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.482 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.482 | |
| 1bi9 | NAD | Retinal dehydrogenase 2 | / | 0.481 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.481 | |
| 4h73 | NDP | Aldehyde dehydrogenase | / | 0.481 | |
| 4nmj | NAP | Aldehyde dehydrogenase | / | 0.481 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.480 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.479 | |
| 2ehq | NAP | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.478 | |
| 3iwj | NAD | Aminoaldehyde dehydrogenase | / | 0.476 | |
| 4i3w | NAD | Aldehyde dehydrogenase (NAD+) | / | 0.476 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.475 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.475 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.474 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.474 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 4i8q | NAD | Putative betaine aldehyde dehyrogenase | / | 0.474 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.473 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.473 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.473 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.472 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.472 | |
| 3rbq | GLY_ALA_GLY_DAO | Protein unc-119 homolog A | / | 0.472 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.471 | |
| 3syi | FAD | Sulfide-quinone reductase | / | 0.471 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.471 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.470 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.470 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.470 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.470 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.470 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.469 | |
| 1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.469 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.469 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.468 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.468 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.468 | |
| 4i3v | NAD | Aldehyde dehydrogenase (NAD+) | / | 0.468 | |
| 3gb4 | D3M | DdmC | / | 0.467 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.467 | |
| 4nr4 | 2LK | CREB-binding protein | / | 0.467 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.467 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.466 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.466 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.465 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.465 | |
| 4pzd | NAD | 3-Hydroxyacyl-CoA dehydrogenase | / | 0.465 | |
| 1ppj | ANY | Cytochrome b | / | 0.464 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 3stv | 3HO | Methylketone synthase I | / | 0.464 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.464 | |
| 4xo7 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.464 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.463 | |
| 1uxn | NAP | NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase | / | 0.463 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.463 | |
| 4dl9 | NAD | S-(hydroxymethyl)glutathione dehydrogenase | / | 0.463 | |
| 4l9k | EHF | Serum albumin | / | 0.463 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.463 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.463 | |
| 2kce | D16 | Thymidylate synthase | / | 0.462 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.462 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.462 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.462 | |
| 2vtb | FAD | Cryptochrome DASH, chloroplastic/mitochondrial | / | 0.461 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.461 | |
| 3stu | DK3 | Methylketone synthase I | / | 0.461 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.461 | |
| 5cwa | 0GA | Anthranilate synthase component 1 | 4.1.3.27 | 0.461 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.460 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.460 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.460 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.460 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.460 | |
| 3ih0 | ANP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.460 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 4n9w | GDP | Phosphatidyl-myo-inositol mannosyltransferase | 2.4.1.57 | 0.460 | |
| 1g6o | ADP | Cag alpha | / | 0.459 | |
| 2a87 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.459 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.459 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.459 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.459 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.459 | |
| 5dp2 | NAP | CurF | / | 0.459 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.458 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.458 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.458 | |
| 3etd | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.458 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.458 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.458 | |
| 4ez7 | 2AN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 4j2w | FAD | Kynurenine 3-monooxygenase | / | 0.458 | |
| 4riy | ADP | Epidermal growth factor receptor | 2.7.10.1 | 0.458 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.458 | |
| 5eox | ADP | Type 4 fimbrial biogenesis protein PilM | / | 0.458 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.457 | |
| 3nbv | ANP | Ketohexokinase | / | 0.457 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.457 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.457 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.457 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.457 | |
| 4jji | NAD | Alcohol dehydrogenase class-3 | / | 0.457 | |
| 4v37 | NAD | Betaine aldehyde dehydrogenase, chloroplastic | 1.2.1.8 | 0.457 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.456 | |
| 1i3m | UD1 | UDP-glucose 4-epimerase | / | 0.456 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.456 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.456 | |
| 3ids | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.456 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.456 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.456 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.456 | |
| 1a7k | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.455 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.455 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.455 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.455 | |
| 1rjk | VDZ | Vitamin D3 receptor | / | 0.455 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.455 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.455 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.455 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.455 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.455 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.455 | |
| 4jq8 | KJ8 | Epidermal growth factor receptor | 2.7.10.1 | 0.455 | |
| 4kxn | 6K6 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | / | 0.455 | |
| 4l1x | NAP | Aldo-keto reductase family 1 member C2 | / | 0.455 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 2j6l | NAI | Alpha-aminoadipic semialdehyde dehydrogenase | 1.2.1.31 | 0.454 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.454 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.454 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.454 | |
| 4xf7 | ACP | Carbohydrate/pyrimidine kinase, PfkB family | / | 0.454 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.453 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.453 | |
| 1yqd | NAP | Sinapyl alcohol dehydrogenase | / | 0.453 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.453 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.453 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.453 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.453 | |
| 3qtu | X44 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.453 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.453 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.453 | |
| 5i2f | BS5 | Histidine triad nucleotide-binding protein 1 | 3 | 0.453 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.452 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.452 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.452 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.452 | |
| 2xaa | NAD | Secondary alcohol dehydrogenase | / | 0.452 | |
| 2yyy | NAP | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.59 | 0.452 | |
| 3iup | NDP | Possible NADH oxidoreductase | / | 0.452 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.452 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.452 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.452 | |
| 4irn | FAD | AnaB | / | 0.452 | |
| 4nt0 | 3DU | Orotidine 5'-phosphate decarboxylase | 4.1.1.23 | 0.452 | |
| 5c3z | ACP | Ribokinase | / | 0.452 | |
| 5kf9 | ACO | Predicted acetyltransferase | / | 0.452 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.451 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.451 | |
| 1iy8 | NAD | Levodione reductase | / | 0.451 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.451 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.451 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.451 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2i3g | NAP | N-acetyl-gamma-glutamyl-phosphate reductase | 1.2.1.38 | 0.451 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.451 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.451 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.451 | |
| 3stx | BKA | Methylketone synthase I | / | 0.451 | |
| 3t14 | FAD | Sulfide-quinone reductase | / | 0.451 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.451 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.451 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.451 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.451 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.451 | |
| 4id7 | 1G0 | Activated CDC42 kinase 1 | / | 0.451 | |
| 4ijp | 1EH | Serine/threonine-protein kinase PRP4 homolog | 2.7.11.1 | 0.451 | |
| 4kto | FAD | Putative isovaleryl-CoA dehydrogenase protein | / | 0.451 | |
| 4xcv | NDP | Probable hydroxyacid dehydrogenase protein | / | 0.451 | |
| 5a3c | NAD | SIR2 family protein | / | 0.451 | |
| 1aiq | CB3 | Thymidylate synthase | / | 0.450 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.450 | |
| 1gqt | ACP | Ribokinase | / | 0.450 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.450 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.450 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.450 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.450 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.450 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.450 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.450 | |
| 3bbr | BHY | Glutamate receptor 2 | / | 0.450 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.450 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.450 | |
| 4h50 | NAP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.450 | |
| 4hjo | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.450 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.450 | |
| 4jq7 | KJQ | Epidermal growth factor receptor | 2.7.10.1 | 0.450 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.450 | |
| 4oe2 | NAD | 2-aminomuconate 6-semialdehyde dehydrogenase | / | 0.450 | |
| 5kf1 | ACO | Predicted acetyltransferase | / | 0.450 | |
| 5kj1 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.450 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.449 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 1t7i | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 2bja | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.449 | |
| 2onm | ADP | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.449 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.449 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.449 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.449 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.449 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.449 | |
| 4x2q | NAD | Retinal dehydrogenase 2 | 1.2.1.36 | 0.449 | |
| 5eoy | ADP | Type 4 fimbrial biogenesis protein PilM | / | 0.449 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.448 | |
| 1o8c | NDP | Probable acrylyl-CoA reductase AcuI | 1.3.1.84 | 0.448 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.448 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.448 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.448 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.448 | |
| 2p9e | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.448 | |
| 2qhm | 7CS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.448 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.448 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.448 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.448 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.448 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.448 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.448 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.448 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 4oaq | NDP | R-specific carbonyl reductase | / | 0.448 | |
| 4rls | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.448 | |
| 5dr6 | SKE | Aurora kinase A | 2.7.11.1 | 0.448 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.448 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.447 | |
| 1d0l | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.447 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.447 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.447 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 2aa0 | MTP | Adenosine kinase | 2.7.1.20 | 0.447 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.447 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.447 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.447 | |
| 2xx9 | 1NF | Glutamate receptor 2 | / | 0.447 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.447 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3lki | ATP | Fructokinase | / | 0.447 | |
| 3t2y | FAD | Sulfide-quinone reductase | / | 0.447 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.447 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4eqg | A5A | Histidine triad nucleotide-binding protein 1 | 3 | 0.447 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.447 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.447 | |
| 4ng5 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.447 | |
| 5cdt | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
| 5hsa | FAS | Alcohol oxidase 1 | 1.1.3.13 | 0.447 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.446 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.446 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.446 | |
| 1jut | LYD | Thymidylate synthase | / | 0.446 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.446 | |
| 1q12 | ATP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.446 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.446 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 1z0z | NAD | NAD kinase | / | 0.446 | |
| 2pob | GW4 | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 2r2n | KYN | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.446 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.446 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.446 | |
| 3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.446 | |
| 3vwd | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.446 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.446 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4c4o | NAD | SADH | / | 0.446 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.446 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.446 | |
| 5ikq | JMS | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.446 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.445 | |
| 1j21 | ATP | Argininosuccinate synthase | / | 0.445 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.445 | |
| 1npt | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.445 | |
| 1sq5 | ADP | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 1t0l | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.445 | |
| 1uxt | NAD | NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase | / | 0.445 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.445 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.445 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 2fvl | NAP | Aldo-keto reductase family 1 member C4 | 1.1.1.225 | 0.445 | |
| 2x4f | 16X | Myosin light chain kinase family member 4 | 2.7.11.1 | 0.445 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.445 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.445 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.445 | |
| 3rwp | ABQ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.445 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.445 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.445 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.445 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.445 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.445 | |
| 5kjc | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.445 | |
| 1cc2 | FAD | Cholesterol oxidase | 1.1.3.6 | 0.444 | |
| 1d0m | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.444 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.444 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.444 | |
| 2e48 | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.444 | |
| 2pa7 | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.444 | |
| 2pmd | GNP | Translation initiation factor 2 subunit gamma | / | 0.444 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.444 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.444 | |
| 3if9 | FAD | Glycine oxidase | 1.4.3.19 | 0.444 | |
| 3iod | A6D | Pantothenate synthetase | 6.3.2.1 | 0.444 | |
| 3nbw | TR4 | Ketohexokinase | / | 0.444 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.444 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.444 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.444 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.444 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.444 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.444 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.444 | |
| 4rqu | NAD | Alcohol dehydrogenase class-P | / | 0.444 | |
| 5kgh | ACO | Predicted acetyltransferase | / | 0.444 | |
| 1o0s | NAI | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.443 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.443 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 1yqx | NAP | Sinapyl alcohol dehydrogenase | / | 0.443 | |
| 1zdw | FLV | Prenyltransferase | / | 0.443 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.443 | |
| 2gs7 | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.443 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 2tps | TPS | Thiamine-phosphate synthase | / | 0.443 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.443 | |
| 3haz | FAD | Bifunctional protein PutA | / | 0.443 | |
| 3umv | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.443 | |
| 3v3m | 0EN | Replicase polyprotein 1a | 3.4.19.12 | 0.443 | |
| 3w5q | 3KL | Vitamin D3 receptor | / | 0.443 | |
| 4eua | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.443 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.443 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.443 | |
| 5ify | UMP | Glucose-1-phosphate thymidylyltransferase | / | 0.443 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.442 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.442 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.442 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.442 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.442 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.442 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.442 | |
| 1yba | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.442 | |
| 2aot | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.442 | |
| 2dbq | NAP | Glyoxylate reductase | 1.1.1.26 | 0.442 | |
| 2j40 | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.442 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.442 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.442 | |
| 3caq | NDP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3hja | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.442 | |
| 3kve | FAD | L-amino-acid oxidase | / | 0.442 | |
| 3oq1 | 3OQ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.442 | |
| 3rqq | BA3 | ADP-dependent (S)-NAD(P)H-hydrate dehydratase | / | 0.442 | |
| 3uqd | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.442 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.442 | |
| 3znp | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.442 | |
| 4b5p | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.442 | |
| 4cdm | FAD | Deoxyribodipyrimidine photolyase | / | 0.442 | |
| 4gkv | NAD | Alcohol dehydrogenase, propanol-preferring | 1.1.1.1 | 0.442 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.442 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.442 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.442 | |
| 4rnx | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.442 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.442 | |
| 4uun | NAI | L-lactate dehydrogenase | / | 0.442 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.442 | |
| 1ad3 | NAD | Aldehyde dehydrogenase, dimeric NADP-preferring | / | 0.441 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.441 | |
| 1o02 | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.441 | |
| 1osv | CHC | Bile acid receptor | / | 0.441 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.441 | |
| 2cgv | 3B3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2g9u | G27 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.441 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.441 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.441 | |
| 3ete | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.441 | |
| 3qbh | QBH | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3rq6 | APR | ADP-dependent (S)-NAD(P)H-hydrate dehydratase | / | 0.441 | |
| 3u9e | COA | Lmo1369 protein | / | 0.441 | |
| 4l8u | 9AZ | Serum albumin | / | 0.441 | |
| 4lt6 | 3AT | Poly(A) polymerase gamma | 2.7.7.19 | 0.441 | |
| 4pvd | NDP | NADPH-dependent methylglyoxal reductase GRE2 | / | 0.441 | |
| 4pxl | NAD | Aldehyde dehydrogenase3 | / | 0.441 | |
| 5byu | COA | Thioesterase | / | 0.441 | |
| 5doz | NDP | JamJ | / | 0.441 | |
| 1d7l | RFL | p-hydroxybenzoate hydroxylase | / | 0.440 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.440 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.440 | |
| 1nzx | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.440 | |
| 1tys | DHF | Thymidylate synthase | / | 0.440 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.440 | |
| 2fze | APR | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.440 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.440 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 3jvv | ACP | Twitching mobility protein | / | 0.440 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.440 | |
| 3mjh | GTP | Ras-related protein Rab-5A | / | 0.440 | |
| 3nwz | COA | BH2602 protein | / | 0.440 | |
| 3r8v | Z62 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3sdk | P3N | Proteasome subunit beta type-5 | 3.4.25.1 | 0.440 | |
| 3sdk | P3N | Proteasome subunit beta type-6 | 3.4.25.1 | 0.440 | |
| 3sz0 | FAD | Sulfide-quinone reductase | / | 0.440 | |
| 4dpl | NAP | Malonyl-CoA reductase | 1.2.1.75 | 0.440 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.440 | |
| 4jr3 | KJR | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.440 |