sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2pdn | 47D | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 1.000 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.739 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.719 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.711 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.706 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.689 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.686 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.668 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.657 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.657 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.654 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.650 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.645 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.642 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.641 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.639 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.634 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.633 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.633 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.632 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.632 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.629 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.629 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.628 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.626 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.626 | |
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 0.623 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.623 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.623 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.622 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.620 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.619 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.618 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.617 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.617 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.615 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.614 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.613 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.612 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.612 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.610 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.609 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.609 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.609 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.607 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.606 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.603 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.597 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.596 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.595 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.593 | |
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.585 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.582 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.570 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.567 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.555 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.555 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.548 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.546 | |
| 2ikh | LIT | Aldose reductase | 1.1.1.21 | 0.542 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.525 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.516 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.516 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.513 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.512 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.508 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.507 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.505 | |
| 3ugr | IMN | Aldo-keto reductase family 1 member C3 | / | 0.505 | |
| 1rxj | BNI | Streptavidin | / | 0.502 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.501 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.501 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.501 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.501 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.500 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.500 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.499 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.498 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.497 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.495 | |
| 3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.495 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.494 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.494 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.493 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.493 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.492 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.492 | |
| 4kn0 | MTX | Folate receptor beta | / | 0.492 | |
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.491 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.491 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.491 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.491 | |
| 4jqa | ID8 | Aldo-keto reductase family 1 member C2 | / | 0.491 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.490 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.489 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.489 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.489 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.489 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.489 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.489 | |
| 4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.489 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.488 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.488 | |
| 2gmv | UN8 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.488 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.487 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.487 | |
| 4kmz | FOL | Folate receptor beta | / | 0.487 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.486 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.485 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.484 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.484 | |
| 4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.484 | |
| 4kn2 | LYA | Folate receptor beta | / | 0.484 | |
| 2rd6 | 78P | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.483 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.483 | |
| 4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.483 | |
| 4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.483 | |
| 1s36 | CEI | Obelin | / | 0.482 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.482 | |
| 3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.482 | |
| 3gsi | THG | Dimethylglycine oxidase | 1.5.3.10 | 0.482 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.481 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.481 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.481 | |
| 4kn1 | 04J | Folate receptor beta | / | 0.481 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.481 | |
| 1tfz | 869 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.480 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.480 | |
| 2wmd | ZZ0 | NmrA-like family domain-containing protein 1 | / | 0.480 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.480 | |
| 4jq3 | ZOM | Aldo-keto reductase family 1 member C2 | / | 0.480 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.479 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.479 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.479 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.479 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.479 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3rm8 | RM8 | Acidic mammalian chitinase | 3.2.1.14 | 0.479 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.479 | |
| 4nqg | CZH | Mitrocomin | / | 0.479 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.478 | |
| 3cas | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.478 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.478 | |
| 4x3u | SVR | Chromobox protein homolog 7 | / | 0.478 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.478 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.477 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.477 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.477 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.477 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.477 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.476 | |
| 3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.476 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.476 | |
| 4gab | FID | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.476 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.476 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.476 | |
| 5d5a | CAU | Beta-2 adrenergic receptor | / | 0.476 | |
| 1ef3 | FID | Aldose reductase | 1.1.1.21 | 0.475 | |
| 1pwm | FID | Aldose reductase | 1.1.1.21 | 0.475 | |
| 2pdy | FID | Aldose reductase | 1.1.1.21 | 0.475 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.475 | |
| 3hii | PNT | Amiloride-sensitive amine oxidase [copper-containing] | / | 0.475 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.475 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 2y04 | 68H | Beta-1 adrenergic receptor | / | 0.475 | |
| 5cxv | 0HK | Muscarinic acetylcholine receptor M1 | / | 0.475 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.475 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.474 | |
| 1rvv | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.474 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.474 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.474 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.474 | |
| 2hzq | STR | Apolipoprotein D | / | 0.474 | |
| 3dz6 | M8E | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.474 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.474 | |
| 4jq1 | NPS | Aldo-keto reductase family 1 member C2 | / | 0.474 | |
| 1q83 | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
| 3w2e | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.473 | |
| 1isg | AGS | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.472 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.472 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.472 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.472 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.472 | |
| 2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.472 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.472 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.472 | |
| 3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 0.472 | |
| 1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.471 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.471 | |
| 3fvu | IAC | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.471 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.471 | |
| 3ocw | 3AM | Lipoprotein E | / | 0.471 | |
| 4mm7 | 29J | Na(+):neurotransmitter symporter (Snf family) | / | 0.471 | |
| 1dpm | EBP | Parathion hydrolase | 3.1.8.1 | 0.470 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.470 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.470 | |
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.470 | |
| 3nhp | HGZ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.470 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.470 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.470 | |
| 1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.469 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.469 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.469 | |
| 3t0k | DCQ | Sulfide-quinone reductase | / | 0.469 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.469 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.469 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.469 | |
| 4mrx | CZH | Obelin | / | 0.469 | |
| 4paa | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.469 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.468 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.468 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.468 | |
| 1k4m | NAD | Nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.467 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.467 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.467 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.467 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.467 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.467 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.466 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.466 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.466 | |
| 3cv6 | HXS | Aldo-keto reductase family 1 member C21 | / | 0.466 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.466 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.466 | |
| 4hhy | 15R | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.466 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.465 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 2v0m | KLN | Cytochrome P450 3A4 | / | 0.465 | |
| 2vrj | NCW | Beta-glucosidase A | 3.2.1.21 | 0.465 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.465 | |
| 3hf8 | ML0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.465 | |
| 3iu9 | T07 | Methionine aminopeptidase 2 | / | 0.465 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.465 | |
| 4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.465 | |
| 4jvn | YUG | Estrogen sulfotransferase | 2.8.2.4 | 0.465 | |
| 4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 5dsy | UHB | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.465 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.464 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.464 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.464 | |
| 3v2u | ATP | Protein GAL3 | / | 0.464 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.464 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.464 | |
| 1isj | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.463 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2g7y | MO9 | Cathepsin S | 3.4.22.27 | 0.463 | |
| 2gg0 | U11 | Methionine aminopeptidase | / | 0.463 | |
| 3l3m | A92 | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.463 | |
| 3lzz | GDP | Uncharacterized protein | / | 0.463 | |
| 3szf | DCQ | Sulfide-quinone reductase | / | 0.463 | |
| 4iks | TFD | Methionine aminopeptidase 1 | / | 0.463 | |
| 5cto | NTD | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.463 | |
| 1ah0 | SBI | Aldose reductase | 1.1.1.21 | 0.462 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.462 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 2rcw | AAI | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.462 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.462 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.462 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.462 | |
| 4xd1 | T3Q | Qdtf | / | 0.462 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 1pj7 | FFO | Dimethylglycine oxidase | 1.5.3.10 | 0.461 | |
| 1q6n | P90 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.461 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.461 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.461 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.461 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 4i5x | FLF | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.461 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.460 | |
| 1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.460 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.460 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 2jf6 | S55 | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.460 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.460 | |
| 3cui | X4S | Exoglucanase/xylanase | 3.2.1.91 | 0.460 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 3tyl | AXW | Nitric oxide synthase, brain | 1.14.13.39 | 0.460 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 3zwx | AV1 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase | 3.2.2.6 | 0.460 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.460 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.460 | |
| 4xwt | U5P | Ribonuclease J | / | 0.460 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.460 | |
| 1rpw | DID | HTH-type transcriptional regulator QacR | / | 0.459 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.459 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.459 | |
| 1xi2 | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.459 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 2bd0 | BIO | Sepiapterin reductase | / | 0.459 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.459 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3rth | RTH | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.459 | |
| 4jvm | XDI | Estrogen sulfotransferase | 2.8.2.4 | 0.459 | |
| 4myq | 19T | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.459 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.458 | |
| 3l3l | L3L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.458 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 3pn1 | IVH | DNA ligase | / | 0.458 | |
| 3r43 | ID8 | Aldo-keto reductase family 1 member C3 | / | 0.458 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.458 | |
| 4dri | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.458 | |
| 4dri | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.458 | |
| 4g2w | NI0 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.458 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.458 | |
| 1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.457 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.457 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.457 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.457 | |
| 1t47 | NTD | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.457 | |
| 1z4i | UMP | 5'(3')-deoxyribonucleotidase, mitochondrial | 3.1.3 | 0.457 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.457 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.457 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.457 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.457 | |
| 3r58 | NPS | Aldo-keto reductase family 1 member C3 | / | 0.457 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.457 | |
| 4h7c | 10H | Aldo-keto reductase family 1 member C3 | / | 0.457 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.457 | |
| 4j7h | TRH | PCZA361.3 | / | 0.457 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.457 | |
| 4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1el4 | CTZ | Obelin | / | 0.456 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.456 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.456 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.456 | |
| 4fal | 0T0 | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
| 4fll | YZ6 | Methionine aminopeptidase 1 | / | 0.456 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.456 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.456 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.456 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.455 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.455 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.455 | |
| 3ocx | 2AM | Lipoprotein E | / | 0.455 | |
| 3r7m | SUZ | Aldo-keto reductase family 1 member C3 | / | 0.455 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.455 | |
| 3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.455 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.455 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.455 | |
| 5dsg | 0HK | Muscarinic acetylcholine receptor M4 | / | 0.455 | |
| 1qv0 | CZH | Obelin | / | 0.454 | |
| 1vrq | FON | Subunit alpha of sarocosine oxidase | / | 0.454 | |
| 2aj4 | ANP | Galactokinase | 2.7.1.6 | 0.454 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 3b82 | NAD | Exotoxin A | 2.4.2.36 | 0.454 | |
| 3nfr | EWQ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.454 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.454 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 1lke | DOG | Bilin-binding protein | / | 0.453 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.453 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 2g6p | HM2 | Methionine aminopeptidase 1 | / | 0.453 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.453 | |
| 2nq7 | HM5 | Methionine aminopeptidase 1 | / | 0.453 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.453 | |
| 2vt4 | P32 | Beta-1 adrenergic receptor | / | 0.453 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.453 | |
| 3k45 | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.453 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.453 | |
| 4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.453 | |
| 4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.453 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 5a4w | QCT | Glutathione S-transferase F2 | 2.5.1.18 | 0.453 | |
| 4daj | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.453 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.452 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.452 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.452 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.452 | |
| 3d2d | REN | Reticuline oxidase | 1.21.3.3 | 0.452 | |
| 3hyw | DCQ | Sulfide-quinone reductase | / | 0.452 | |
| 3r6i | JMS | Aldo-keto reductase family 1 member C3 | / | 0.452 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 4mmd | 29E | Na(+):neurotransmitter symporter (Snf family) | / | 0.452 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.452 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.452 | |
| 4u15 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.452 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.451 | |
| 2evc | FC3 | Methionine aminopeptidase | / | 0.451 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.451 | |
| 2rd2 | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.451 | |
| 2vqq | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.451 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 3dla | NXX | Glutamine-dependent NAD(+) synthetase | 6.3.5.1 | 0.451 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.451 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.451 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.451 | |
| 4itx | IN5 | Cystathionine beta-lyase MetC | 4.4.1.8 | 0.451 | |
| 4mdk | U94 | Ubiquitin-conjugating enzyme E2 R1 | / | 0.451 | |
| 4tjy | 3GN | Tankyrase-2 | 2.4.2.30 | 0.451 | |
| 4yfy | 0FX | VioF | / | 0.451 | |
| 1sg0 | STL | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.450 | |
| 1u70 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.450 | |
| 2hct | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.450 | |
| 2iu8 | UD1 | UDP-3-O-acylglucosamine N-acyltransferase | 2.3.1 | 0.450 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 2oym | MNI | Endoglycoceramidase II | / | 0.450 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3h0w | N8M | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.450 | |
| 3hgg | CHD | CmeR | / | 0.450 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.450 | |
| 3x02 | 5GP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.450 | |
| 4bjc | RPB | Tankyrase-2 | 2.4.2.30 | 0.450 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.450 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.450 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.450 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.449 | |
| 2q94 | A04 | Methionine aminopeptidase | / | 0.449 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 3bjc | WAN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.449 | |
| 3bmq | AX5 | Pteridine reductase | / | 0.449 | |
| 3jq7 | DX2 | Pteridine reductase, putative | / | 0.449 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.449 | |
| 4n3r | 2GU | Tankyrase-1 | 2.4.2.30 | 0.449 | |
| 4pnr | G18 | Tankyrase-2 | 2.4.2.30 | 0.449 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1kwc | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.448 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.448 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.448 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.448 | |
| 2ipw | 2CL | Aldose reductase | 1.1.1.21 | 0.448 | |
| 2y0d | UGA | UDP-glucose dehydrogenase | / | 0.448 | |
| 3cv7 | C2U | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.448 | |
| 3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.448 | |
| 3sfx | JAN | Uncharacterized protein | / | 0.448 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.448 | |
| 3zpq | XF5 | Beta-1 adrenergic receptor | / | 0.448 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.448 | |
| 4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.448 | |
| 4bfd | 8T3 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 4dz5 | NAP | Aldo-keto reductase family 1 member C3 | / | 0.448 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.448 | |
| 4jt9 | 1NS | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.448 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1icq | OPD | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.447 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 1uhj | CZB | Aequorin-2 | / | 0.447 | |
| 2b8j | ADN | Class B acid phosphatase | 3.1.3.2 | 0.447 | |
| 2b96 | ANN | Phospholipase A2 | 3.1.1.4 | 0.447 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 2xej | OKD | Glutamate carboxypeptidase 2 | 3.4.17.21 | 0.447 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2zoz | ET | Transcriptional regulator | / | 0.447 | |
| 3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.447 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.447 | |
| 3cr7 | PPS | Adenylyl-sulfate kinase | 2.7.1.25 | 0.447 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.447 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3o9l | LPN | Renin | 3.4.23.15 | 0.447 | |
| 3rvi | RVI | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4br3 | U85 | Choline kinase alpha | 2.7.1.32 | 0.447 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.447 | |
| 4k88 | HFG | Bifunctional glutamate/proline--tRNA ligase | 6.1.1.15 | 0.447 | |
| 4lsj | LSJ | Glucocorticoid receptor | / | 0.447 | |
| 4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.447 | |
| 4wlj | IK2 | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.447 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.446 | |
| 2iej | S48 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.446 | |
| 2qx7 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.446 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.446 | |
| 3ce0 | P34 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.446 | |
| 3dr7 | GPD | GDP-perosamine synthase | / | 0.446 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 3n39 | FMN | Protein NrdI | / | 0.446 | |
| 3n61 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.446 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.446 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.446 | |
| 4flk | Y10 | Methionine aminopeptidase 1 | / | 0.446 | |
| 4gtr | 7TR | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.446 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.446 | |
| 4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.446 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.445 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.445 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.445 | |
| 2wnb | C5P | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 | 2.4.99.4 | 0.445 | |
| 2yg3 | FAD | Putrescine oxidase | / | 0.445 | |
| 3c1o | NAP | Eugenol synthase | / | 0.445 | |
| 3ele | PLP | Aminotransferase | / | 0.445 | |
| 3jq8 | DX3 | Pteridine reductase, putative | / | 0.445 | |
| 3n3b | FMN | Protein NrdI | / | 0.445 | |
| 3ox2 | 79X | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.445 | |
| 3r8g | IZP | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.445 | |
| 4jq2 | SUZ | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 4mm4 | 8PR | Na(+):neurotransmitter symporter (Snf family) | / | 0.445 | |
| 4qjc | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 5ds3 | 09L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.445 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 1m2x | MCO | Metallo-beta-lactamase type 2 | / | 0.444 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.444 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.444 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.444 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2qjp | ANJ | Cytochrome b | / | 0.444 | |
| 2vqb | NAP | Putative flavin-containing monooxygenase | / | 0.444 | |
| 3af4 | GCP | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 3dz7 | O8M | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.444 | |
| 3jq6 | DX1 | Pteridine reductase, putative | / | 0.444 | |
| 3nhr | RZW | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.444 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.444 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.444 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 3wi2 | P98 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4bvh | AR6 | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.444 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.444 | |
| 4ihi | NAD | Probable pyrroline-5-carboxylate dehydrogenase RocA | / | 0.444 | |
| 4jtr | IBP | Aldo-keto reductase family 1 member C2 | / | 0.444 | |
| 4phl | PIL | Phosphodiesterase | / | 0.444 | |
| 4rxr | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.444 | |
| 5bn4 | ANP | V-type ATP synthase alpha chain | / | 0.444 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2c97 | JCL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 2ct8 | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.443 | |
| 2f2h | XTG | Alpha-xylosidase | 3.2.1.177 | 0.443 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.443 | |
| 2ycw | CAU | Beta-1 adrenergic receptor | / | 0.443 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.443 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.443 | |
| 3gey | P34 | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.443 | |
| 3pah | XDE | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.443 | |
| 3rgz | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.443 | |
| 2ycz | I32 | Beta-1 adrenergic receptor | / | 0.443 | |
| 3ny8 | JRZ | Beta-2 adrenergic receptor | / | 0.443 | |
| 1dls | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 1s1r | NAP | Aldo-keto reductase family 1 member C3 | / | 0.442 | |
| 1vp5 | NAP | Oxidoreductase, aldo/keto reductase family | / | 0.442 | |
| 2i8c | ADP | D-alanine--D-alanine ligase | / | 0.442 | |
| 2qt0 | NNR | Nicotinamide riboside kinase 1 | / | 0.442 | |
| 2y03 | 5FW | Beta-1 adrenergic receptor | / | 0.442 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3dr4 | G4M | GDP-perosamine synthase | / | 0.442 | |
| 3e33 | ED7 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.442 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.442 | |
| 3fu8 | 3DM | Laccase-1 | 1.10.3.2 | 0.442 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.442 | |
| 3hfb | ML4 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.442 | |
| 3ksq | Z96 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.442 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
| 3owx | XRA | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
| 3pz2 | 3PZ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.442 | |
| 3ua1 | 08Y | Cytochrome P450 3A4 | / | 0.442 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4dkb | DUN | Deoxyuridine triphosphatase, putative | / | 0.442 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.442 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4glx | 0XS | DNA ligase | 6.5.1.2 | 0.442 | |
| 4lrh | FOL | Folate receptor alpha | / | 0.442 | |
| 4mm9 | FVX | Na(+):neurotransmitter symporter (Snf family) | / | 0.442 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.442 | |
| 4qoe | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.442 | |
| 5e9e | ANP | Myosin heavy chain kinase A | 2.7.11.7 | 0.442 | |
| 1az1 | ALR | Aldose reductase | 1.1.1.21 | 0.441 | |
| 1by5 | GLY_GLY_GLY_AHO_AHO_AHO_FE | Ferrichrome-iron receptor | / | 0.441 | |
| 1dtp | APU | Diphtheria toxin | / | 0.441 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1e2l | TMC | Thymidine kinase | / | 0.441 | |
| 1ja1 | FMN | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 1kyy | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.441 | |
| 1ni1 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 1nl4 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.441 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.441 | |
| 2ggb | U17 | Methionine aminopeptidase | / | 0.441 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2j0s | ANP | Eukaryotic initiation factor 4A-III | 3.6.4.13 | 0.441 | |
| 2qry | TPS | Thiamine-binding periplasmic protein | / | 0.441 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2x9v | TMQ | Pteridine reductase | / | 0.441 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.441 | |
| 3nhl | YTR | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.441 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.441 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.441 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.441 | |
| 4fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.441 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.441 | |
| 4gvs | F4M | Methenyltetrahydromethanopterin cyclohydrolase | 3.5.4.27 | 0.441 | |
| 4j3m | AJ8 | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 4j7g | TRH | PCZA361.3 | / | 0.441 | |
| 4lcn | GNG | Cytidine and deoxycytidylate deaminase zinc-binding region | / | 0.441 | |
| 4lwx | MU2 | Ribosome inactivating protein | / | 0.441 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.441 | |
| 4x9d | U5P | Uncharacterized protein MJ1435 | / | 0.441 | |
| 2ycy | P32 | Beta-1 adrenergic receptor | / | 0.441 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2q15 | 3MR | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2vq3 | NAP | Metalloreductase STEAP3 | / | 0.440 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 3h4g | FID | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.440 | |
| 3r94 | FLR | Aldo-keto reductase family 1 member C3 | / | 0.440 | |
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.440 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
| 4nwi | CTN | 7-methylguanosine phosphate-specific 5'-nucleotidase | / | 0.440 | |
| 4q7f | 3D1 | Uncharacterized protein | / | 0.440 | |
| 5c1g | GDU | Histo-blood group ABO system transferase | / | 0.440 | |
| 5d0r | B1T | Adenylate cyclase type 10 | / | 0.440 |