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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ioaADPBifunctional glutathionylspermidine synthetase/amidase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ioaADPBifunctional glutathionylspermidine synthetase/amidase/1.000
2io7ANPBifunctional glutathionylspermidine synthetase/amidase/0.583
2io8ADPBifunctional glutathionylspermidine synthetase/amidase/0.565
2a19ANPInterferon-induced, double-stranded RNA-activated protein kinase2.7.11.10.536
1x8b824Wee1-like protein kinase2.7.10.20.531
2o7pNAPRiboflavin biosynthesis protein RibD/0.526
5iqfGDPBifunctional AAC/APH2.3.10.522
5iqgGDPBifunctional AAC/APH2.3.10.519
2io9ADPBifunctional glutathionylspermidine synthetase/amidase/0.516
1r8qAFBCytohesin-2/0.513
1r8qAFBADP-ribosylation factor 1/0.513
4bkjSTIEpithelial discoidin domain-containing receptor 12.7.10.10.512
1i2cUPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.506
1qrrUPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.506
5iqaGNPBifunctional AAC/APH2.3.10.505
1id0ANPSensor protein PhoQ2.7.13.30.503
4xzjNADPutative NAD(+)--arginine ADP-ribosyltransferase Vis2.4.2.310.502
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.501
2xrlDXTTetracycline repressor protein class D/0.500
5bylGCPBifunctional AAC/APH2.3.10.500
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.499
1yqj6NPMitogen-activated protein kinase 14/0.498
2cahNDPCatalase1.11.1.60.498
3d5wADPSerine/threonine-protein kinase PLK/0.497
1hfqMOTDihydrofolate reductase1.5.1.30.494
5iqbGNPBifunctional AAC/APH2.3.10.494
5cvhADPCasein kinase II subunit alpha2.7.11.10.493
3bi6396Wee1-like protein kinase2.7.10.20.492
5iqeGNPBifunctional AAC/APH2.3.10.492
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.491
3hkoANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands/0.491
3qeoLLTDeoxycytidine kinase2.7.1.740.491
2w5aADPSerine/threonine-protein kinase Nek22.7.11.10.490
3nszANPCasein kinase II subunit alpha2.7.11.10.490
4lv8ADPRhoptry protein 5 C/0.490
4orkGDPBifunctional AAC/APH2.3.10.489
4d7mTDCTetracycline repressor protein class D/0.488
3q60ATPRhoptry protein 5B/0.487
5iqiGNPBifunctional AAC/APH2.3.10.487
4a3uFMNNADH:flavin oxidoreductase/NADH oxidase/0.486
4eixNIMPhospholipase A2 VRV-PL-VIIIa/0.486
2zdt46CMitogen-activated protein kinase 102.7.11.240.485
3hziATPSerine/threonine-protein kinase toxin HipA/0.484
2j9gADPBiotin carboxylase6.3.4.140.483
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.483
1ne4RP1cAMP-dependent protein kinase type I-alpha regulatory subunit/0.482
2e20B4PPropionate kinase/0.481
3nksACJProtoporphyrinogen oxidase1.3.3.40.481
4bixADPSensor histidine kinase CpxA/0.481
4f1oACPProbable serine/threonine-protein kinase roco42.7.11.10.481
1u1cBAUUridine phosphorylase2.4.2.30.480
2fjdSFDAdenylylsulfate reductase, subunit A (AprA)/0.480
4bgbADPPredicted molecular chaperone distantly related to HSP70-fold metalloproteases/0.480
1y5xE89Queuine tRNA-ribosyltransferase2.4.2.290.479
2o7oDXTTetracycline repressor protein class D/0.479
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.479
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.479
4f1mACPProbable serine/threonine-protein kinase roco42.7.11.10.479
5iqdGNPBifunctional AAC/APH2.3.10.479
2pulACPMethylthioribose kinase2.7.1.1000.478
2y6fM9FIsopenicillin N synthase1.21.3.10.478
3t99ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.478
1iahADPTransient receptor potential cation channel subfamily M member 72.7.11.10.477
2glxNDP1,5-anhydro-D-fructose reductase/0.477
2j9lATPH(+)/Cl(-) exchange transporter 5/0.477
4y6uUPGGlucosyl-3-phosphoglycerate synthase2.4.1.2660.477
5iqhGNPBifunctional AAC/APH2.3.10.477
3ae4FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.476
3fhxPXLPyridoxal kinase2.7.1.350.476
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.476
4autFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.476
4fxfATPPyruvate kinase PKM2.7.1.400.476
3v0o4GWHisto-blood group ABO system transferase/0.475
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.475
2pupADPMethylthioribose kinase2.7.1.1000.474
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.474
2z2w770Wee1-like protein kinase2.7.10.20.473
3up0D7SaceDAF-12/0.473
4e37NDPCatalase1.11.1.60.473
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.473
5fkmTDCTetracycline repressor protein class D/0.473
1vyrFMNPentaerythritol tetranitrate reductase/0.472
3pchCHBProtocatechuate 3,4-dioxygenase beta chain1.13.11.30.472
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.472
4k5o1OTM1 family aminopeptidase3.4.110.472
1orkATCTetracycline repressor protein class D/0.471
1xelUPGUDP-glucose 4-epimerase5.1.3.20.471
3juqAKDPhenazine biosynthesis protein A/B/0.471
4lrjANPUncharacterized protein/0.471
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.471
4xbfFADLysine-specific histone demethylase 1A10.471
1a9zUPGUDP-glucose 4-epimerase5.1.3.20.470
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.470
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.470
2pdtFADVivid PAS protein VVD/0.470
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.470
3cgyRDCVirulence sensor histidine kinase PhoQ2.7.13.30.470
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.470
4foxUMPThymidylate synthase ThyA/0.470
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.470
1a5uATPPyruvate kinase PKM2.7.1.400.469
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.469
1o9bNAIQuinate/shikimate dehydrogenase/0.469
2vbpVB1Isopenicillin N synthase1.21.3.10.469
3akkADPSerine/threonine-protein kinase CtkA2.7.11.10.469
3epsATPIsocitrate dehydrogenase kinase/phosphatase/0.469
4a99MIYTetX family tetracycline inactivation enzyme/0.469
4gdpFADPolyamine oxidase FMS1/0.469
1i44ACPInsulin receptor2.7.10.10.468
1oc1ASVIsopenicillin N synthase1.21.3.10.468
2vqdAP2Biotin carboxylase6.3.4.140.468
3rv3ADPBiotin carboxylase6.3.4.140.468
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.468
1bwkFMNNADPH dehydrogenase 11.6.99.10.467
2geuCOKPantothenate kinase2.7.1.330.467
2vkdUPGCytotoxin L/0.467
3biz61EWee1-like protein kinase2.7.10.20.467
4xe606UDihydrofolate reductase1.5.1.30.467
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.467
1i24UPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.466
2a5kAZPReplicase polyprotein 1ab3.4.220.466
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.466
3a7jADPSerine/threonine-protein kinase 242.7.11.10.466
3q44D50M1 family aminopeptidase3.4.110.466
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.466
3t9dANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.466
4jbtASDCytochrome P450 monooxygenase/0.466
4jr7GNPCasein kinase II subunit alpha2.7.11.10.466
5fkoTDCTetracycline repressor protein class D/0.466
1b39ATPCyclin-dependent kinase 22.7.11.220.465
1qiqACCIsopenicillin N synthase1.21.3.10.465
3c4wATPRhodopsin kinase/0.465
3datMTXDihydrofolate reductase/0.465
3l3rOAGDihydrofolate reductase1.5.1.30.465
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.465
3pfhT3QdTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase2.1.1.2350.465
3pn1IVHDNA ligase/0.465
3tdvGDPGentamicin resistance protein/0.465
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.465
4jlm1NNDeoxycytidine kinase2.7.1.740.465
1a9yUPGUDP-glucose 4-epimerase5.1.3.20.464
1w29TS06,7-dimethyl-8-ribityllumazine synthase2.5.1.780.464
1xbtTTPThymidine kinase, cytosolic2.7.1.210.464
1zydATPeIF-2-alpha kinase GCN2/0.464
2wo7ASVIsopenicillin N synthase1.21.3.10.464
4cavMYAGlycylpeptide N-tetradecanoyltransferase2.3.1.970.464
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.464
4klnAGSTransitional endoplasmic reticulum ATPase3.6.4.60.464
4lv5ADPRhoptry protein 5B/0.464
1ne6SP1cAMP-dependent protein kinase type I-alpha regulatory subunit/0.463
2owb626Serine/threonine-protein kinase PLK12.7.11.210.463
3kfmKAIGlutamate receptor 4/0.463
3p2oNADBifunctional protein FolD/0.463
4b2gV1NUncharacterized protein/0.463
4qmlANPSerine/threonine-protein kinase 242.7.11.10.463
1z6lFADPolyamine oxidase FMS1/0.462
2pl0STITyrosine-protein kinase Lck2.7.10.20.462
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.462
3g1oRF1HTH-type transcriptional regulator EthR/0.462
3p8iFMNPentaerythritol tetranitrate reductase/0.462
1lhwESMSex hormone-binding globulin/0.461
2cjfRP43-dehydroquinate dehydratase4.2.1.100.461
2hq9FADMll6688 protein/0.461
2ol4JPNEnoyl-ACP reductase/0.461
2vmyFFOSerine hydroxymethyltransferase/0.461
3copADPGlycogen synthase2.4.1.210.461
4hj4FMNLOV protein/0.461
1f8gNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.460
1h36R88Squalene--hopene cyclase4.2.1.1290.460
1obnASVIsopenicillin N synthase1.21.3.10.460
2e1zB4PPropionate kinase/0.460
2in6839Wee1-like protein kinase2.7.10.20.460
2r4uADPGlycogen synthase2.4.1.210.460
2vkvTDCTetracycline repressor protein class D/0.460
2xpwOTCTetracycline repressor protein class D/0.460
3ed1GA3Gibberellin receptor GID1/0.460
3zhqTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.460
4bqyFNTEgl nine homolog 1/0.460
4fvqATPTyrosine-protein kinase JAK2/0.460
1t13INI6,7-dimethyl-8-ribityllumazine synthase 2/0.459
1yp3ATPGlucose-1-phosphate adenylyltransferase small subunit, chloroplastic/amyloplastic2.7.7.270.459
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.459
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.459
2vbdV10Isopenicillin N synthase1.21.3.10.459
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.459
3dntATPSerine/threonine-protein kinase toxin HipA/0.459
4b5nFMNNAD(P)H:flavin oxidoreductase Sye4/0.459
4bqwQNMEgl nine homolog 1/0.459
4zm3PLPAminotransferase/0.459
1h51FMNPentaerythritol tetranitrate reductase/0.458
1knrFADL-aspartate oxidase1.4.3.160.458
1t0iFMNNAD(P)H-dependent FMN reductase LOT6/0.458
1yhjR6CPyridoxal kinase2.7.1.350.458
2puiADPMethylthioribose kinase2.7.1.1000.458
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.458
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.458
2xpvMIYTetracycline repressor protein class D/0.458
3gncQQQGlutaryl-CoA dehydrogenase/0.458
3pxkPXKFocal adhesion kinase 12.7.10.20.458
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.458
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.458
1adfTADAlcohol dehydrogenase E chain1.1.1.10.457
1knpFADL-aspartate oxidase1.4.3.160.457
1l8qADPChromosomal replication initiator protein DnaA/0.457
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.457
1ygjRMCPyridoxal kinase2.7.1.350.457
2c29NAPDihydroflavonol 4-reductase/0.457
2qk8MTXDihydrofolate reductase/0.457
3a783EVVitamin D3 receptor/0.457
3bx5304Mitogen-activated protein kinase 14/0.457
4at4T6EBDNF/NT-3 growth factors receptor2.7.10.10.457
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.457
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.457
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.457
5cwa0GAAnthranilate synthase component 14.1.3.270.457
1e94ANPATP-dependent protease ATPase subunit HslU/0.456
1h63FMNPentaerythritol tetranitrate reductase/0.456
1ppjANYCytochrome b/0.456
2ozoANPTyrosine-protein kinase ZAP-702.7.10.20.456
3bgxMEFThymidylate synthase/0.456
3otwCOAPhosphopantetheine adenylyltransferase/0.456
4bmpFMNProtein NrdI/0.456
4ubvCOASteroid 3-ketoacyl-CoA thiolase/0.456
5ebuFMNLactate oxidase/0.456
1ewyFADFerredoxin--NADP reductase1.18.1.20.455
1i5aACPChemotaxis protein CheA2.7.13.30.455
1k4gAIQQueuine tRNA-ribosyltransferase2.4.2.290.455
1ol5ADPAurora kinase A2.7.11.10.455
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.455
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.455
1u54ACPActivated CDC42 kinase 1/0.455
2bfmTOPPteridine reductase 11.5.1.330.455
2x7jTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.455
3rl35GPMetallophosphoesterase MPPED23.10.455
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.455
4ma628EAra h 8 allergen/0.455
4z69DIFSerum albumin/0.455
1txtCAAHMG-CoA synthase/0.454
2bakAQZMitogen-activated protein kinase 14/0.454
3hgoFMN12-oxophytodienoate reductase 31.3.1.420.454
3p97SAMGenome polyprotein2.1.1.560.454
3tptADPSerine/threonine-protein kinase toxin HipA/0.454
3zhvTDWMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.454
4a9yAQZMitogen-activated protein kinase 14/0.454
4auxXTCTetracycline repressor protein class D/0.454
4ix5ANPUncharacterized protein/0.454
4jva1ORcAMP-dependent protein kinase type II-beta regulatory subunit/0.454
4s33ANPMitogen-activated protein kinase 12.7.11.240.454
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.454
5e92ANPTGF-beta receptor type-22.7.11.300.454
1cdkANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
1equEQIEstradiol 17-beta-dehydrogenase 11.1.1.620.453
1fq1ATPCyclin-dependent kinase 22.7.11.220.453
1g7uPEP2-dehydro-3-deoxyphosphooctonate aldolase2.5.1.550.453
1q45FMN12-oxophytodienoate reductase 31.3.1.420.453
1wp4NDP3-hydroxyisobutyrate dehydrogenase/0.453
2vdyHCYCorticosteroid-binding globulin/0.453
2zzaFOLDihydrofolate reductase/0.453
3ormAGSSerine/threonine protein kinase/0.453
4bb2STRCorticosteroid-binding globulin/0.453
4cnzADPNitrogen regulatory protein P-II 1/0.453
4e6q0NVTyrosine-protein kinase JAK2/0.453
4n3l2FNProthrombin3.4.21.50.453
1hb1OCVIsopenicillin N synthase1.21.3.10.452
1vbiNADMalate/L-lactate dehydrogenase family protein/0.452
1ygkRRCPyridoxal kinase2.7.1.350.452
2bufADPAcetylglutamate kinase/0.452
2cvzNDP3-hydroxyisobutyrate dehydrogenase/0.452
2q3oFMN12-oxophytodienoate reductase 31.3.1.420.452
2qqfA1RNAD-dependent protein deacetylase HST23.5.10.452
2w3mFOLDihydrofolate reductase1.5.1.30.452
3e6eDCSAlanine racemase/0.452
3pduNAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase/0.452
3tvqDQHMultifunctional cyclase-dehydratase-3-O-methyl transferase TcmN2.1.10.452
4ac0MIYTetracycline repressor protein class B from transposon Tn10/0.452
4fehFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.452
4fevPP1Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.452
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.452
4nfsNAJAlcohol dehydrogenase E chain1.1.1.10.452
4rgsV55Repressor protein/0.452
4y6nUPGGlucosyl-3-phosphoglycerate synthase2.4.1.2660.452
5fm7ADPRuvB-like helicase/0.452
1icqFMN12-oxophytodienoate reductase 11.3.1.420.451
1nqxRLP6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.451
1pq944BOxysterols receptor LXR-beta/0.451
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.451
1rd4L08Integrin alpha-L/0.451
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.451
2iw5FADLysine-specific histone demethylase 1A10.451
2kceD16Thymidylate synthase/0.451
2tsrUMPThymidylate synthase2.1.1.450.451
2z4sADPChromosomal replication initiator protein DnaA/0.451
2zsdCOAPantothenate kinase2.7.1.330.451
2zsiGA4Gibberellin receptor GID1A30.451
3fhxPLPPyridoxal kinase2.7.1.350.451
3ingNDPHomoserine dehydrogenase related protein/0.451
3llaACPMyosin heavy chain kinase A2.7.11.70.451
3nguADPNucleoside diphosphate kinase/0.451
3v0m5GWHisto-blood group ABO system transferase/0.451
3w5q3KLVitamin D3 receptor/0.451
4rnxFMNNADPH dehydrogenase 11.6.99.10.451
4y95746Tyrosine-protein kinase/0.451
1cm8ANPMitogen-activated protein kinase 12/0.450
1crbRTLRetinol-binding protein 1/0.450
1f28UMPThymidylate synthase2.1.1.450.450
1ftlDNQGlutamate receptor 2/0.450
1mf0GDPAdenylosuccinate synthetase isozyme 1/0.450
1mvsDTMDihydrofolate reductase1.5.1.30.450
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.450
2nodH4BNitric oxide synthase, inducible1.14.13.390.450
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.450
2pbwDOQGlutamate receptor ionotropic, kainate 1/0.450
3f03FMNPentaerythritol tetranitrate reductase/0.450
3iw4LW4Protein kinase C alpha type2.7.11.130.450
3p67FMNPentaerythritol tetranitrate reductase/0.450
3p74FMNPentaerythritol tetranitrate reductase/0.450
3t7oUPGGlycogenin-12.4.1.1860.450
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
4f0fACPProbable serine/threonine-protein kinase roco42.7.11.10.450
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.450
4fr10V2Queuine tRNA-ribosyltransferase2.4.2.290.450
4hj6FMNLOV protein/0.450
4o4fATPKinase/0.450
4r38RBFBlue-light-activated histidine kinase 22.7.13.30.450
5ab7MLCNonspecific lipid-transfer protein, putative/0.450
1bwlFMNNADPH dehydrogenase 11.6.99.10.449
1dgbNDPCatalase1.11.1.60.449
1e92HBIPteridine reductase 11.5.1.330.449
1fduNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.449
1lb9DNQGlutamate receptor 2/0.449
1lp4ANPCasein kinase II subunit alpha2.7.11.10.449
1ri2GTGmRNA cap guanine-N7 methyltransferase2.1.1.560.449
1u1d181Uridine phosphorylase2.4.2.30.449
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.449
2vi5Y196,7-dimethyl-8-ribityllumazine synthase2.5.1.780.449
2y60M8FIsopenicillin N synthase1.21.3.10.449
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.449
3is2FADVivid PAS protein VVD/0.449
3o9pMHIPeriplasmic murein peptide-binding protein/0.449
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.449
3tw6ADPPyruvate carboxylase/0.449
4oauADP2-5A-dependent ribonuclease3.1.260.449
4tx9AMZPhosphoribosyl isomerase A/0.449
4xybNDPFormate dehydrogenase/0.449
4yau2AMNADPH--cytochrome P450 reductase/0.449
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.449
5bsfNADPyrroline-5-carboxylate reductase/0.449
1f3eDPZQueuine tRNA-ribosyltransferase2.4.2.290.448
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.448
1jnkANPMitogen-activated protein kinase 102.7.11.240.448
1jnrFADAdenylylsulfate reductase, subunit A (AprA)/0.448
1mczRMNBenzoylformate decarboxylase4.1.1.70.448
1n83CLRNuclear receptor ROR-alpha/0.448
1zzlTZYMitogen-activated protein kinase 14/0.448
2c97JCL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.448
2fzjDH3Dihydrofolate reductase1.5.1.30.448
2g8yNADHydroxycarboxylate dehydrogenase B/0.448
2hs8FMN12-oxophytodienoate reductase 31.3.1.420.448
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.448
2zi53L1Deoxycytidine kinase2.7.1.740.448
3fl4FL4Mitogen-activated protein kinase 14/0.448
3fowIMHPurine nucleoside phosphorylase/0.448
3jziJZLBiotin carboxylase6.3.4.140.448
3qge26FGenome polyprotein2.7.7.480.448
3zhrTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.448
4f9aADPCell division cycle 7-related protein kinase2.7.11.10.448
4fhd0TTSpore photoproduct lyase/0.448
4l8u9AZSerum albumin/0.448
4qx5CMPcGMP-dependent protein kinase 12.7.11.120.448
5e9eANPMyosin heavy chain kinase A2.7.11.70.448
3qakUKAAdenosine receptor A2a/0.448
1cdeGARPhosphoribosylglycinamide formyltransferase/0.447
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.447
1qjfACSIsopenicillin N synthase1.21.3.10.447
2j6xFMNLactate oxidase/0.447
3bi2FADPolyamine oxidase FMS1/0.447
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
3k4551PDihydrofolate reductase1.5.1.30.447
3lmhADPMyosin heavy chain kinase A2.7.11.70.447
3r8uZ31Cyclin-dependent kinase 22.7.11.220.447
3sa16DRDihydrofolate reductase/0.447
3zkyWT4Isopenicillin N synthase1.21.3.10.447
4deg0JJHepatocyte growth factor receptor2.7.10.10.447
4k5p1OSM1 family aminopeptidase3.4.110.447
1bsvNDPGDP-L-fucose synthase/0.446
1csnATPCasein kinase I homolog 12.7.11.10.446
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.446
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.446
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
1srfMTBStreptavidin/0.446
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.446
2hog710Serine/threonine-protein kinase Chk12.7.11.10.446
2i0v6C3Macrophage colony-stimulating factor 1 receptor2.7.10.10.446
2iviACWIsopenicillin N synthase1.21.3.10.446
2pa7TYDTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase5.3.2.30.446
2rirNAPDipicolinate synthase subunit A/0.446
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
3cndFADPolyamine oxidase FMS1/0.446
3cr0809Wee1-like protein kinase2.7.10.20.446
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.446
3h0bB35Beta-secretase 13.4.23.460.446
3hxdBD7Geranylgeranyl transferase type-2 subunit beta2.5.1.600.446
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.446
3nmpPYVAbscisic acid receptor PYL2/0.446
3to3ATPPetrobactin biosynthesis protein AsbB/0.446
4becATPType I restriction enzyme EcoR124II R protein3.1.21.30.446
4k39SAMAnaerobic sulfatase-maturating enzyme1.8.980.446
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.446
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.446
4yaf2AMNADPH--cytochrome P450 reductase/0.446
5c2tFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.446
5iotUMPFlavin-dependent thymidylate synthase2.1.1.1480.446
5iu86DZAdenosine receptor A2a/0.446
1dghNDPCatalase1.11.1.60.445
1ig1ANPDeath-associated protein kinase 12.7.11.10.445
1opbRETRetinol-binding protein 2/0.445
1pnqNDPNAD(P) transhydrogenase subunit beta1.6.1.20.445
1s4dSAHUroporphyrinogen-III C-methyltransferase2.1.1.1070.445
1towCRZFatty acid-binding protein, adipocyte/0.445
1ykdCMPAdenylate cyclase/0.445
2a9z26AAdenosine kinase2.7.1.200.445
2fwzH71Heat shock protein HSP 90-alpha/0.445
2gjnFMNNitronate monooxygenase1.13.12.160.445
2iypA2P6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.445
3hgsFMN12-oxophytodienoate reductase 31.3.1.420.445
3l7lC2GTeichoic acid poly(glycerol phosphate) polymerase/0.445
3t5iSER_SER_CMT_FARRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.445
3x2vATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
4eevL1XHepatocyte growth factor receptor2.7.10.10.445
4gh10WXQueuine tRNA-ribosyltransferase2.4.2.290.445
4jseQJ2Nitric oxide synthase, brain1.14.13.390.445
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.445
4or0NPSSerum albumin/0.445
4qnyANPMitogen activated protein kinase, putative/0.445
5dt3ATPAurora kinase A2.7.11.10.445
5hbsRTLRetinol-binding protein 1/0.445
1bcpATPPertussis toxin subunit 4/0.444
1bcpATPPertussis toxin subunit 5/0.444
1e2nRCAThymidine kinase/0.444
1oyaFMNNADPH dehydrogenase 11.6.99.10.444
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.444
2bgiFADNADPH:ferredoxin reductase/0.444
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.444
2trtTACTetracycline repressor protein class D/0.444
2vf7ADPUvrABC system protein A/0.444
2xvv9DNSerum albumin/0.444
3aklANPSerine/threonine-protein kinase CtkA2.7.11.10.444
3hu3AGSTransitional endoplasmic reticulum ATPase3.6.4.60.444
3i587NA2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase/0.444
3lfeZ84Mitogen-activated protein kinase 14/0.444
3n5yH4BNitric oxide synthase, brain1.14.13.390.444
3pdtADPMyosin heavy chain kinase A2.7.11.70.444
3t4eNADQuinate/shikimate dehydrogenase/0.444
4aoaIK2Beta-phenylalanine transaminase2.6.10.444
4frjDWBBeta-secretase 13.4.23.460.444
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.444
4n8iCOAPutative 4-hydroxybutyrate coenzyme A transferase/0.444
4nj32KDCyclin-dependent kinase 22.7.11.220.444
5bt42LOBromodomain-containing protein 4/0.444
5fknTDCTetracycline repressor protein class D/0.444
5kf9COAPredicted acetyltransferase/0.444
1eqbFFOSerine hydroxymethyltransferase2.1.2.10.443
1hb3SCVIsopenicillin N synthase1.21.3.10.443
1psdNADD-3-phosphoglycerate dehydrogenase1.1.1.950.443
1zsnTN2Enoyl-ACP reductase/0.443
2ed3SAHDiphthine synthase/0.443
2ihvTPPN(2)-(2-carboxyethyl)arginine synthase/0.443
2j5xGSPADP-ribosylation factor 6/0.443
2r8pT6FTransketolase 1/0.443
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.443
3bbpGTPRas-related protein Rab-6A/0.443
3pce3HPProtocatechuate 3,4-dioxygenase alpha chain1.13.11.30.443
3pce3HPProtocatechuate 3,4-dioxygenase beta chain1.13.11.30.443
3pqbVGPPutative oxidoreductase/0.443
3sh25DRDihydrofolate reductase1.5.1.30.443
3ufl508Beta-secretase 13.4.23.460.443
4g95OAGDihydrofolate reductase1.5.1.30.443
4ii5ADPCyclin-dependent kinase 22.7.11.220.443
4mv1ADPBiotin carboxylase6.3.4.140.443
4o1pANPRibonuclease L/0.443
4twnB96Ephrin type-A receptor 32.7.10.10.443
4yswNAIXanthine dehydrogenase/oxidase/0.443
5ab6CAANonspecific lipid-transfer protein, putative/0.443
5dtoSAHGenome polyprotein/0.443
1clqGDPDNA-directed DNA polymerase/0.442
1icsFMN12-oxophytodienoate reductase 11.3.1.420.442
1jnzFADAdenylylsulfate reductase, subunit A (AprA)/0.442
1mqbANPEphrin type-A receptor 22.7.10.10.442
1nhhANPDNA mismatch repair protein MutL/0.442
1qnfHDFDeoxyribodipyrimidine photo-lyase4.1.99.30.442
2dhfDZFDihydrofolate reductase1.5.1.30.442
2q3fGNPRas-related GTP-binding protein D/0.442
2qo6CHDFatty acid-binding protein 10-A, liver basic/0.442
2r4tADPGlycogen synthase2.4.1.210.442
3c14FOKAdenylate cyclase type 2/0.442
3c14FOKAdenylate cyclase type 5/0.442
3c34KAIGlutamate receptor ionotropic, kainate 1/0.442
3fmmXI2Mitogen-activated protein kinase 14/0.442
3kp4MIITranscriptional regulator TcaR/0.442
3lq2TDPPyruvate dehydrogenase E1 component1.2.4.10.442
3mflDHYProtocatechuate 3,4-dioxygenase alpha chain1.13.11.30.442
3mflDHYProtocatechuate 3,4-dioxygenase beta chain1.13.11.30.442
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.442
3sl2ATPSensor histidine kinase WalK/0.442
3t9eADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.442
3wtkTH4Acetylcholine-binding protein/0.442
3wv8ATPHmd co-occurring protein HcgE/0.442
4br0AU1Ectonucleoside triphosphate diphosphohydrolase 2/0.442
4ccqNAPThioredoxin reductase/0.442
4gt8ADPSensor protein VraS2.7.13.30.442
4ha6PXMPyridoxine 4-oxidase/0.442
4l9q9TPSerum albumin/0.442
4ubuCOASteroid 3-ketoacyl-CoA thiolase/0.442
4wfr2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.442
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.442
4y9uNAPNADPH--cytochrome P450 reductase/0.442
5cb4ACPTubulin tyrosine ligase/0.442
5esdTDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.442
1gq2NAPNADP-dependent malic enzyme1.1.1.400.441
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.441
1q4wDQUQueuine tRNA-ribosyltransferase2.4.2.290.441
1yzqGNPRas-related protein Rab-6A/0.441
1z6tADPApoptotic protease-activating factor 1/0.441
1zdwFLVPrenyltransferase/0.441
2abbFMNPentaerythritol tetranitrate reductase/0.441
2db3ANPATP-dependent RNA helicase vasa, isoform A3.6.4.130.441
2ga9AGSPoly(A) polymerase catalytic subunit2.7.7.190.441
2hkoFADLysine-specific histone demethylase 1A10.441
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.441
2obxINI6,7-dimethyl-8-ribityllumazine synthase 22.5.1.780.441
2qzrS79Queuine tRNA-ribosyltransferase2.4.2.290.441
2tctCTCTetracycline repressor protein class D/0.441
2v1aFMNNPH1-1/0.441
3dogNNNCyclin-dependent kinase 22.7.11.220.441
3orkAGSSerine/threonine protein kinase/0.441
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.441
3zdu38RCyclin-dependent kinase-like 32.7.11.220.441
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.441
4b6r3DQ3-dehydroquinate dehydratase4.2.1.100.441
4b6s2HN3-dehydroquinate dehydratase4.2.1.100.441
4blcNDPCatalase1.11.1.60.441
4dhyS41Glucokinase2.7.1.20.441
4gncASORegucalcin3.1.1.170.441
4gyiADPUncharacterized protein/0.441
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.441
5bt9NAP3-oxoacyl-(Acyl-carrier-protein) reductase/0.441
1euyQSIGlutamine--tRNA ligase6.1.1.180.440
1kquBR4Phospholipase A2, membrane associated/0.440
1ohjCOPDihydrofolate reductase1.5.1.30.440
1pxgPRFQueuine tRNA-ribosyltransferase2.4.2.290.440
2bfoNDPPteridine reductase 11.5.1.330.440
2g78REACellular retinoic acid-binding protein 2/0.440
2hf8GSPProbable hydrogenase nickel incorporation protein HypB/0.440
2imkGTXAGAP009194-PA/0.440
2olcADPMethylthioribose kinase2.7.1.1000.440
2x06NADL-sulfolactate dehydrogenase/0.440
2x0rNADMalate dehydrogenase/0.440
2y3pSM8DNA gyrase subunit A/0.440
2ydbNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.440
3bazNAPHydroxyphenylpyruvate reductase1.1.1.2370.440
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.440
3dh7FMNIsopentenyl-diphosphate delta-isomerase/0.440
3er93ATPoly(A) polymerase catalytic subunit2.7.7.190.440
3eufBAUUridine phosphorylase 1/0.440
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.440
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.440
3q43D66M1 family aminopeptidase3.4.110.440
3rdqDTBStreptavidin/0.440
3vpbADPGlutamate--LysW ligase ArgX6.3.20.440
4bfsZVSPantothenate kinase2.7.1.330.440
4f4qFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.440
4l4xNDPAmphI/0.440
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.440
4zmeADNMyosin heavy chain kinase A2.7.11.70.440
5dt9NADErythronate-4-phosphate dehydrogenase/0.440
5iw5NMNNADH pyrophosphatase/0.440