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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1lonIMOAdenylosuccinate synthetase isozyme 1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1lonIMOAdenylosuccinate synthetase isozyme 1/1.000
1kszPGSAdenylosuccinate synthetase/0.624
1qf5RPLAdenylosuccinate synthetase/0.612
2gcqDOIAdenylosuccinate synthetase/0.611
1cg4IMOAdenylosuccinate synthetase/0.610
1cg3IMOAdenylosuccinate synthetase/0.605
1cg0IMOAdenylosuccinate synthetase/0.601
2dgnDOIAdenylosuccinate synthetase isozyme 1/0.601
1p9bIMOAdenylosuccinate synthetase/0.591
1cg1IMOAdenylosuccinate synthetase/0.581
1nhtPGSAdenylosuccinate synthetase/0.577
1qf4RPDAdenylosuccinate synthetase/0.577
3toxNAPPutative oxidoreductase/0.508
3lqfNADGalactitol dehydrogenase/0.499
5dp2NAPCurF/0.495
2ou2ACOHistone acetyltransferase KAT5/0.494
2y0mACOHistone acetyltransferase KAT8/0.493
1lnyIMOAdenylosuccinate synthetase isozyme 1/0.492
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.490
1nvmNADAcetaldehyde dehydrogenase1.2.1.100.488
5cdtNAJAlcohol dehydrogenase E chain1.1.1.10.488
1xe55FEPlasmepsin-23.4.23.390.485
3d8bADPFidgetin-like protein 13.6.40.485
4mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.485
4yaoFMNNADPH--cytochrome P450 reductase/0.485
1f8fNADBenzyl alcohol dehydrogenase/0.484
1ipeNDPTropinone reductase 21.1.1.2360.484
4dbzNDPPutative ketoacyl reductase1.3.10.484
4lcjNADC-terminal-binding protein 2/0.484
1ykfNAPNADP-dependent isopropanol dehydrogenase1.1.1.800.483
3o26NDPSalutaridine reductase/0.483
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.483
3jynNDPQuinone oxidoreductase/0.482
3uaxNOSPurine nucleoside phosphorylase DeoD-type/0.482
3w8eNAD3-hydroxybutyrate dehydrogenase/0.482
1mg5NAIAlcohol dehydrogenase1.1.1.10.481
2ifaFMNUncharacterized protein/0.481
3f1kNAPUncharacterized oxidoreductase YciK10.481
4qxp1YEStimulator of interferon genes protein/0.480
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.479
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.479
4yaiNAIC alpha-dehydrogenase/0.479
1n5dNDPCarbonyl reductase [NADPH] 1/0.478
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.478
2ym1FADPhenylacetone monooxygenase1.14.13.920.478
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.478
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.478
3qwbNDPProbable quinone oxidoreductase1.6.5.50.478
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.478
1m2jAPRNAD-dependent protein deacylase 1/0.477
2a92NAIL-lactate dehydrogenase/0.477
3qlrNDPDihydrofolate reductase1.5.1.30.476
4nd4NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.476
4nu5NADPhosphonate dehydrogenase1.20.1.10.476
2a94AP0L-lactate dehydrogenase1.1.1.270.475
2b4tAESGlyceraldehyde-3-phosphate dehydrogenase/0.475
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.475
4opiFDAConserved Archaeal protein/0.475
1lbcCYZGlutamate receptor 2/0.474
2vbdV10Isopenicillin N synthase1.21.3.10.474
2xlpFADPutative flavin-containing monooxygenase/0.474
4q1x017Gag-Pol polyprotein3.4.23.160.474
1qorNDPQuinone oxidoreductase 1/0.473
2b4rAESGlyceraldehyde-3-phosphate dehydrogenase/0.473
3r95ACOMccE protein/0.473
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.473
1xq6NAPUncharacterized protein At5g02240/0.472
2givACOHistone acetyltransferase KAT8/0.472
4yjdFADD-amino-acid oxidase1.4.3.30.472
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.471
2i4uDJRProtease/0.471
2ylzFADPhenylacetone monooxygenase1.14.13.920.471
3bg7FADPyranose 2-oxidase/0.471
3gqvNAPEnoyl reductase LovC10.471
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.471
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.471
1ia1NDPDihydrofolate reductase1.5.1.30.470
1knpFADL-aspartate oxidase1.4.3.160.470
1p0fNAPNADP-dependent alcohol dehydrogenase1.1.1.20.470
1xddAAYIntegrin alpha-L/0.470
1yqdNAPSinapyl alcohol dehydrogenase/0.470
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.470
3f3sNADLambda-crystallin homolog/0.470
3in6FMNUncharacterized protein/0.470
4mv8ACPBiotin carboxylase6.3.4.140.470
1hetNADAlcohol dehydrogenase E chain1.1.1.10.469
2c0cNAPProstaglandin reductase 310.469
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.469
2il2LIXRenin3.4.23.150.469
2tpsTPSThiamine-phosphate synthase/0.469
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.469
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.469
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.469
4kcfAKMFAD-dependent oxidoreductase/0.469
4xd2NAIAlcohol dehydrogenase E chain1.1.1.10.469
1f0xFADD-lactate dehydrogenase1.1.1.280.468
1jmgUMPThymidylate synthase/0.468
2q4bNAPUncharacterized protein At5g02240/0.468
4nxuADPMitochondrial dynamics protein MID51/0.468
1njbUMPThymidylate synthase/0.467
1tehNADAlcohol dehydrogenase class-31.1.1.10.467
2xhd7T9Glutamate receptor 2/0.467
3vdqNAD3-hydroxybutyrate dehydrogenase/0.467
4ji91M3Tyrosine-protein kinase JAK2/0.467
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.467
4rww2BALmo2692 protein/0.467
1msmJE2Gag-Pol polyprotein3.4.23.160.466
2ebaFADPutative glutaryl-CoA dehydrogenase/0.466
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.466
2getCOKPantothenate kinase2.7.1.330.466
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.466
2xx91NFGlutamate receptor 2/0.466
3b70NAPEnoyl reductase LovC10.466
3nl6ACPUncharacterized protein/0.466
4dc0NDPPutative ketoacyl reductase1.3.10.466
4oztP1AEcdysone receptor, putative/0.466
5hsaFASAlcohol oxidase 11.1.3.130.466
1e3eNAIAlcohol dehydrogenase 41.1.1.10.465
1g1aNADdTDP-glucose 4,6-dehydratase/0.465
1ma0NADAlcohol dehydrogenase class-31.1.1.10.465
1pzgA3DLactate dehydrogenase/0.465
1r37NADNAD-dependent alcohol dehydrogenase1.1.1.10.465
2jahNDPClavaldehyde dehydrogenase/0.465
3d84NDPDihydrofolate reductase1.5.1.30.465
3rpeFADPutative modulator of drug activity/0.465
3sglFADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC/0.465
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.465
4h6rFDAProline dehydrogenase/0.465
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.465
4nxxGDPMitochondrial dynamics protein MID51/0.465
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.464
1x7gNAPPutative ketoacyl reductase1.3.10.464
3cib314Beta-secretase 13.4.23.460.464
3rj9NADAlcohol dehydrogenase1.1.1.10.464
3vfqAR6Poly [ADP-ribose] polymerase 142.4.2.300.464
1ae1NAPTropinone reductase 1/0.463
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.463
1p0hACOMycothiol acetyltransferase2.3.1.1890.463
1sowNADL-lactate dehydrogenase1.1.1.270.463
3qofGDPAtlastin-13.6.50.463
4aqc88ATyrosine-protein kinase JAK2/0.463
4bfxZVXPantothenate kinase2.7.1.330.463
4l4xNDPAmphI/0.463
5idwNAPShort-chain dehydrogenase/reductase SDR/0.463
1lluNADAlcohol dehydrogenase/0.462
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.462
1phhFADp-hydroxybenzoate hydroxylase/0.462
1pq944BOxysterols receptor LXR-beta/0.462
1rx1NAPDihydrofolate reductase1.5.1.30.462
2aa3AP0L-lactate dehydrogenase/0.462
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.462
3mt817TGlycogen phosphorylase, muscle form2.4.1.10.462
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.462
3r96ACOMccE protein/0.462
4hwkNAPSepiapterin reductase1.1.1.1530.462
1drhNAPDihydrofolate reductase1.5.1.30.461
1h2bNAJNAD-dependent alcohol dehydrogenase/0.461
1tllFADNitric oxide synthase, brain1.14.13.390.461
1udyFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.461
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.461
2g5cNADPrephenate dehydrogenase/0.461
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.461
3d3wNAPL-xylulose reductase1.1.1.100.461
3pfdFDAAcyl-CoA dehydrogenase FadE25/0.461
3q71AR6Poly [ADP-ribose] polymerase 142.4.2.300.461
3uylTYDProbable NDP-rhamnosyltransferase/0.461
4cfaWOPIntegrase/0.461
4dfg0JVGag-Pol polyprotein3.4.23.160.461
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.461
4jalSAHtRNA (cytidine(34)-2'-O)-methyltransferase/0.461
4ntdFADThioredoxin reductase/0.461
5mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.461
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.460
1xs7MMIBeta-secretase 13.4.23.460.460
1yqxNAPSinapyl alcohol dehydrogenase/0.460
2a1tFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.460
2b4qNAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.460
2gjlFMNNitronate monooxygenase1.13.12.160.460
3cosNADAlcohol dehydrogenase 41.1.1.10.460
4j7uNAPSepiapterin reductase1.1.1.1530.460
4j7xNAPSepiapterin reductase1.1.1.1530.460
4u03GTPCyclic GMP-AMP synthase/0.460
1n2iPAJPantothenate synthetase6.3.2.10.459
2c29NAPDihydroflavonol 4-reductase/0.459
2fzwNADAlcohol dehydrogenase class-31.1.1.10.459
2geuCOKPantothenate kinase2.7.1.330.459
2iko7IGRenin3.4.23.150.459
2jb4A14Isopenicillin N synthase1.21.3.10.459
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.459
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.459
3ak4NADNADH-dependent quinuclidinone reductase/0.459
3axkNDPRibulose bisphosphate carboxylase large chain4.1.1.390.459
3he3FADUDP-galactopyranose mutase/0.459
3kb1ADPIron-sulfur cluster carrier protein/0.459
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.459
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.459
6adhNADAlcohol dehydrogenase E chain1.1.1.10.459
1ib0NADNADH-cytochrome b5 reductase 31.6.2.20.458
1qrpHH0Pepsin A-43.4.23.10.458
2g1r3IGRenin3.4.23.150.458
2v6gNAP3-oxo-Delta(4,5)-steroid 5-beta-reductase/0.458
3b6zCO7Enoyl reductase LovC10.458
3u4cNDPNADPH-dependent reductase BacG/0.458
4b45GSPTubulin-like protein CetZ2/0.458
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.458
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.458
1egdFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.457
1geeNADGlucose 1-dehydrogenase1.1.1.470.457
1m78NDPDihydrofolate reductase1.5.1.30.457
1x1aSAMC-20 methyltransferase/0.457
2igoFADPyranose 2-oxidase/0.457
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.457
2z54AB1Gag-Pol polyprotein3.4.23.160.457
3ms421NGlycogen phosphorylase, muscle form2.4.1.10.457
3u33FADPutative acyl-CoA dehydrogenase AidB1.3.990.457
3zbrNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.457
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.457
4nbwNADShort-chain dehydrogenase/reductase SDR/0.457
4ng5NAJAlcohol dehydrogenase E chain1.1.1.10.457
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.457
5c3jFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.457
1ldeNADAlcohol dehydrogenase E chain1.1.1.10.456
1ppjANYCytochrome b/0.456
1rwbNADGlucose 1-dehydrogenase1.1.1.470.456
2hm1LIQBeta-secretase 13.4.23.460.456
3ai2NDPNADPH-sorbose reductase/0.456
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.456
4nfsNAJAlcohol dehydrogenase E chain1.1.1.10.456
4tm4FDAKtzI/0.456
4uugPXGBranched-chain amino acid aminotransferase, putative/0.456
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.456
5kjcNAJAlcohol dehydrogenase E chain1.1.1.10.456
6ctsCICCitrate synthase, mitochondrial2.3.3.10.456
1jqiFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial/0.455
1mjbACOHistone acetyltransferase ESA1/0.455
1pqc444Oxysterols receptor LXR-beta/0.455
1psa0ZLPepsin A3.4.23.10.455
2ahrNAPPyrroline-5-carboxylate reductase/0.455
2c20NADUDP-glucose 4-epimerase/0.455
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.455
2ien017Gag-Pol polyprotein3.4.23.160.455
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.455
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.455
3d7kD7KBenzaldehyde lyase/0.455
3r83Z14Cyclin-dependent kinase 22.7.11.220.455
4ambDUDPutative glycosyl transferase/0.455
4bmvNAPShort-chain dehydrogenase/0.455
4dpwAGSMevalonate diphosphate decarboxylase/0.455
4yddMD1DMSO reductase family type II enzyme, molybdopterin subunit/0.455
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.455
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.455
5d3qGDPDynamin-13.6.5.50.455
1jnzFADAdenylylsulfate reductase, subunit A (AprA)/0.454
1kkq471Peroxisome proliferator-activated receptor alpha/0.454
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.454
2fj1CTCTetracycline repressor protein class D/0.454
2hizLIJBeta-secretase 13.4.23.460.454
3gdpFAD(R)-mandelonitrile lyase 24.1.2.100.454
3k4cFADPyranose 2-oxidase/0.454
3oibFDAPutative acyl-CoA dehydrogenase/0.454
3t1tGDPProbable gliding protein mglA/0.454
4b8wNAPGDP-L-fucose synthase1.1.1.2710.454
4dieC5PCytidylate kinase/0.454
4n3cUD1UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.454
4ri1ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase2.3.1.2020.454
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.454
5ahsFADAcyl-CoA dehydrogenase/0.454
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.454
1bwaXV6Gag-Pol polyprotein3.4.23.160.453
1fwkADPHomoserine kinase2.7.1.390.453
1jmiUMPThymidylate synthase/0.453
1qlhNADAlcohol dehydrogenase E chain1.1.1.10.453
1snyNAPLD36273p/0.453
2bu9HFVIsopenicillin N synthase1.21.3.10.453
2dteNAIGlucose 1-dehydrogenase related protein/0.453
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.453
3p4tFAOPutative acyl-CoA dehydrogenase/0.453
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.453
3w8dNAD3-hydroxybutyrate dehydrogenase/0.453
4bfsZVSPantothenate kinase2.7.1.330.453
4dplNAPMalonyl-CoA reductase1.2.1.750.453
4ejmNAPPutative zinc-binding dehydrogenase/0.453
4q4kFMNUncharacterized protein/0.453
4tvbNADHomospermidine synthase2.5.1.440.453
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.453
4wdfA2P2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.453
1adbCNDAlcohol dehydrogenase E chain1.1.1.10.452
1dhrNADDihydropteridine reductase1.5.1.340.452
1h51FMNPentaerythritol tetranitrate reductase/0.452
1mp0NADAlcohol dehydrogenase class-31.1.1.10.452
1ot7IU5Bile acid receptor/0.452
1szgFNSCytochrome b2, mitochondrial1.1.2.30.452
1w48APCNTPase P4/0.452
2jkvNAP6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.452
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.452
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.452
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.452
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.452
4bftZVTPantothenate kinase2.7.1.330.452
4d5gFADCyclohexane-1,2-dione hydrolase3.7.1.110.452
4uckSAMLarge structural protein/0.452
1dapNDPMeso-diaminopimelate D-dehydrogenase1.4.1.160.451
1m2gAPRNAD-dependent protein deacylase 1/0.451
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.451
2z1mNDPGDP-mannose 4,6-dehydratase/0.451
3fstFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.451
3ggoNAIPrephenate dehydrogenase/0.451
3intFDAUDP-galactopyranose mutase5.4.99.90.451
3iqhTYR_ASP_ILECysteine synthase2.5.1.470.451
3ohh3HHBeta-secretase 13.4.23.460.451
3q43D66M1 family aminopeptidase3.4.110.451
3t4nADP5'-AMP-activated protein kinase subunit gamma/0.451
3thyADPDNA mismatch repair protein Msh2/0.451
4abkAR6Poly [ADP-ribose] polymerase 142.4.2.300.451
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.451
4dqe017Gag-Pol polyprotein/0.451
4h4uFADBiphenyl dioxygenase ferredoxin reductase subunit/0.451
4q71FADBifunctional protein PutA/0.451
4qg1DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.451
5c2tFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.451
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.451
1aa6MGDFormate dehydrogenase H1.1.99.330.450
1g6kNADGlucose 1-dehydrogenase1.1.1.470.450
1hkuNADC-terminal-binding protein 11.1.10.450
1lf2R37Plasmepsin-23.4.23.390.450
1w4xFADPhenylacetone monooxygenase1.14.13.920.450
1z4uPH9Polyprotein/0.450
2hveADPNucleoside diphosphate kinase A2.7.4.60.450
2iqgF2IBeta-secretase 13.4.23.460.450
2rcyNAPPyrroline-5-carboxylate reductase/0.450
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.450
2zb3NDPProstaglandin reductase 21.3.1.480.450
2zjwREFCasein kinase II subunit alpha2.7.11.10.450
3cluFADElectron transfer flavoprotein subunit alpha/0.450
3da24MDCarbonic anhydrase 134.2.1.10.450
3hekBD0Heat shock protein HSP 90-alpha/0.450
3lpkZ76Beta-secretase 13.4.23.460.450
3pm9FADPutative oxidoreductase/0.450
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.450
3to6LYS_CMCHistone acetyltransferase ESA1/0.450
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.450
5cdgNAJAlcohol dehydrogenase E chain1.1.1.10.450
1a4wQWEProthrombin3.4.21.50.449
1j1zATPArgininosuccinate synthase/0.449
1me6IVSPlasmepsin-23.4.23.390.449
1piwNAPNADP-dependent alcohol dehydrogenase 61.1.1.20.449
1r6uTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.449
1t2aNDPGDP-mannose 4,6 dehydratase4.2.1.470.449
2b3dFADModulator of drug activity B/0.449
2fonFADAcyl-coenzyme A oxidase/0.449
2ooyATP5'-AMP-activated protein kinase subunit gamma/0.449
2pciSAHDiphthine synthase/0.449
2r0pK2CPutative FAD-monooxygenase/0.449
2xfjVG5Beta-secretase 13.4.23.460.449
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.449
3aw9NADNAD-dependent epimerase/dehydratase/0.449
3ctyFADProbable thioredoxin reductase/0.449
3flyFLYMitogen-activated protein kinase 14/0.449
3oq6NAJAlcohol dehydrogenase E chain1.1.1.10.449
3r9uFADThioredoxin reductase/0.449
3zidGDPTubulin-like protein CetZ/0.449
4iv6FDAIsovaleryl-CoA dehydrogenase/0.449
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.449
4nwzFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.449
4uyf73BBromodomain-containing protein 2/0.449
5ch7MD1DMSO reductase family type II enzyme, molybdopterin subunit/0.449
5jlaNADPutative short-chain dehydrogenase/reductase/0.449
5kczNAJAlcohol dehydrogenase E chain1.1.1.10.449
1d0lBLGMembrane-bound lytic murein transglycosylase B4.2.2.n10.448
1heuNADAlcohol dehydrogenase E chain1.1.1.10.448
1nq5NADGlyceraldehyde-3-phosphate dehydrogenase/0.448
1oaaNAPSepiapterin reductase1.1.1.1530.448
1vdcFADThioredoxin reductase 1, mitochondrial1.8.1.90.448
2dfvNADL-threonine 3-dehydrogenase/0.448
2omeNADC-terminal-binding protein 2/0.448
2pncCLUPrimary amine oxidase, liver isozyme/0.448
2z1qFADAcyl-CoA dehydrogenase/0.448
3bgxTMPThymidylate synthase/0.448
3btsNADGalactose/lactose metabolism regulatory protein GAL80/0.448
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.448
3o9hK2EGag-Pol polyprotein/0.448
3sx2NADUncharacterized protein/0.448
4dwvNAJAlcohol dehydrogenase E chain1.1.1.10.448
4ly91YYGlucokinase regulatory protein/0.448
4m4922YL-lactate dehydrogenase A chain1.1.1.270.448
4n48SAMCap-specific mRNA (nucleoside-2'-O-)-methyltransferase 12.1.1.570.448
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
5ao1DG3Deoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.448
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.448
1b15NAEAlcohol dehydrogenase1.1.1.10.447
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.447
1n7hNDPGDP-mannose 4,6 dehydratase 24.2.1.470.447
1t2cNAIL-lactate dehydrogenase1.1.1.270.447
1w6hTITPlasmepsin-23.4.23.390.447
1ybmNAPUncharacterized protein At5g02240/0.447
2c1zU2FAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.447
2i0aMUIProtease/0.447
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.447
2vkeTACTetracycline repressor protein class D/0.447
3bgcLJHGag-Pol polyprotein3.4.23.160.447
3dmeFADPutative conserved exported protein/0.447
3fpzAHZThiamine thiazole synthase/0.447
3k5c0BIBeta-secretase 13.4.23.460.447
3p8z36AGenome polyprotein2.1.1.560.447
3tog079Gag-Pol polyprotein2.7.7.490.447
4dh60KNBeta-secretase 13.4.23.460.447
4egbNADdTDP-glucose 4,6-dehydratase/0.447
4irnFADAnaB/0.447
5af7FADAcyl-CoA dehydrogenase/0.447
8dfrNDPDihydrofolate reductase1.5.1.30.447
1di8DTQCyclin-dependent kinase 22.7.11.220.446
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.446
1hdrNADDihydropteridine reductase1.5.1.340.446
1kzkJE2Gag-Pol polyprotein3.4.23.160.446
2eudGCQRibonucleoside-diphosphate reductase large chain 11.17.4.10.446
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.446
2qn7HBZGlycogen phosphorylase, muscle form2.4.1.10.446
2vjmCOAFormyl-CoA:oxalate CoA-transferase/0.446
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.446
2xlsFADPutative flavin-containing monooxygenase/0.446
2xy3DUPSPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS3.6.1.230.446
2yvgNADFerredoxin reductase/0.446
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
3dl0AP5Adenylate kinase/0.446
3lpiZ74Beta-secretase 13.4.23.460.446
3o6o94MHeat shock protein 83/0.446
3toh079Gag-Pol polyprotein2.7.7.490.446
3tscNADUncharacterized protein/0.446
3zbzOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.446
4blrUTPNTPase P4/0.446
4gah0ETAcyl-coenzyme A thioesterase THEM43.1.2.20.446
4jk3NADUncharacterized protein/0.446
5kjfNAJAlcohol dehydrogenase E chain1.1.1.10.446
5l3dFADLysine-specific histone demethylase 1A10.446
1grgFADGlutathione reductase, mitochondrial1.8.1.70.445
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.445
1j49NADD-lactate dehydrogenase1.1.1.280.445
1k08BZDGlycogen phosphorylase, muscle form2.4.1.10.445
1kc1NDPdTDP-4-dehydrorhamnose reductase1.1.1.1330.445
1kolNADGlutathione-independent formaldehyde dehydrogenase/0.445
1mj9COAHistone acetyltransferase ESA1/0.445
1mjaCOAHistone acetyltransferase ESA1/0.445
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.445
2fxeDR7Gag-Pol polyprotein3.4.23.160.445
2p20PRXAcetyl-coenzyme A synthetase/0.445
2prbCOAAminoglycoside 6-N-acetyltransferase type Ib11/0.445
2vwqNAPGlucose 1-dehydrogenase/0.445
2wtkANPSTE20-related kinase adapter protein alpha/0.445
3ab1FADFerredoxin--NADP reductase1.18.1.20.445
3ai3NDPNADPH-sorbose reductase/0.445
3cifNADGlyceraldehyde-3-phosphate dehydrogenase/0.445
3gbuATPUncharacterized sugar kinase PH14592.7.10.445
3ixj586Beta-secretase 13.4.23.460.445
3k5gBJCBeta-secretase 13.4.23.460.445
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.445
4d89BXDBeta-secretase 13.4.23.460.445
4df2FMNNADPH dehydrogenase/0.445
4jb1FADUDP-N-acetylenolpyruvoylglucosamine reductase/0.445
4oaqNDPR-specific carbonyl reductase/0.445
4rosAPRMalate dehydrogenase/0.445
5a1tNAIL-lactate dehydrogenase/0.445
5ez7FADProbable FAD-dependent oxidoreductase PA4991/0.445
1gcoNADGlucose 1-dehydrogenase1.1.1.470.444
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.444
1jnrFADAdenylylsulfate reductase, subunit A (AprA)/0.444
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.444
1t7kBH0Gag-Pol polyprotein3.4.23.160.444
1vceSAHDiphthine synthase/0.444
2a0yDIHPurine nucleoside phosphorylase2.4.2.10.444
2hdjNDPAldo-keto reductase family 1 member C2/0.444
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.444
2q1tNADPutative nucleotide sugar epimerase/ dehydratase/0.444
3bbrBHYGlutamate receptor 2/0.444
3cic316Beta-secretase 13.4.23.460.444
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.444
3elcF012-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.444
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.444
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.444
3owaFADAcyl-CoA dehydrogenase/0.444
4a6cQG9Gag-Pol polyprotein3.4.23.160.444
4acxS8ZBeta-secretase 13.4.23.460.444
4b66FADL-ornithine N(5)-monooxygenase/0.444
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.444
4bv9NDPKetimine reductase mu-crystallin1.5.1.250.444
4cf1IY7Integrase/0.444
4dl9NADS-(hydroxymethyl)glutathione dehydrogenase/0.444
4dxhNAJAlcohol dehydrogenase E chain1.1.1.10.444
4i4b1CV3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.444
4jjiNADAlcohol dehydrogenase class-3/0.444
4kvmSER_ALA_SER_GLU_1XEN-terminal acetyltransferase A complex catalytic subunit ard12.3.1.880.444
4lx9ACON-alpha-acetyltransferase2.3.10.444
4opgFDAConserved Archaeal protein/0.444
4qi5FADCellobiose dehydrogenase/0.444
4weqNAPNAD-dependent dehydrogenase/0.444
4z24FADPutative GMC-type oxidoreductase R13510.444
5dbfNDPIridoid synthase1.3.1.990.444
5jscFADPutative acyl-CoA dehydrogenase/0.444
1bwsNDPGDP-L-fucose synthase/0.443
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.443
1hyhNADL-2-hydroxyisocaproate dehydrogenase/0.443
1jmhUMPThymidylate synthase/0.443
1n2hPAJPantothenate synthetase6.3.2.10.443
1qyvNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1rfvADPPyridoxal kinase2.7.1.350.443
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
2i7pACOPantothenate kinase 32.7.1.330.443
2ignFADPyranose 2-oxidase/0.443
2o23NAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.443
2qrqS13Glycogen phosphorylase, muscle form2.4.1.10.443
2rgoFADAlpha-Glycerophosphate Oxidase/0.443
2rr1W8RGenome polyprotein/0.443
3ieuGDPGTPase Era/0.443
3k4nFADPyranose 2-oxidase/0.443
3lsiFADPyranose 2-oxidase/0.443
3lzu017Gag-Pol polyprotein3.4.23.160.443
3pdqKC6Lysine-specific demethylase 4A1.14.110.443
3s7dLEU_SER_LYS_LYS_MLZN-lysine methyltransferase SMYD2/0.443
3sjzGNPTranslation initiation factor 2 subunit gamma/0.443
3uovFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.443
4g7gVFVLanosterol 14-alpha-demethylase/0.443
4jtqNAPAldo-keto reductase family 1 member C2/0.443
4mxeACON-acetyltransferase ESCO12.3.10.443
4nh82LCHeat shock protein HSP 90-alpha/0.443
4qi7FADCellobiose dehydrogenase/0.443
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.443
4yagNAIC alpha-dehydrogenase/0.443
4ytnFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.443
5c7hNDPPutative oxidoreductase/0.443
5dmhADP3-oxo-tetronate kinase/0.443
5dozNDPJamJ/0.443
1cf3FADGlucose oxidase1.1.3.40.442
1culFOKAdenylate cyclase type 2/0.442
1culFOKAdenylate cyclase type 5/0.442
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.442
1fcbFMNCytochrome b2, mitochondrial1.1.2.30.442
1g4tFTPThiamine-phosphate synthase/0.442
1jkx138Phosphoribosylglycinamide formyltransferase/0.442
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.442
1orrNADCDP-paratose 2-epimerase/0.442
1qo8FADFumarate reductase flavoprotein subunit/0.442
1xe65FPPlasmepsin-23.4.23.390.442
2c27ACOMycothiol acetyltransferase2.3.1.1890.442
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.442
2f3eAXQBeta-secretase 13.4.23.460.442
3c1y2BADNA integrity scanning protein DisA/0.442
3d91REMRenin3.4.23.150.442
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.442
3dm6757Beta-secretase 13.4.23.460.442
3em3478Gag-Pol polyprotein3.4.23.160.442
3f63GTXGlutathione transferase GST1-4/0.442
3hy7097A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.442
3l77NJPShort-chain alcohol dehydrogenase/0.442
3l7dDK5Glycogen phosphorylase, muscle form2.4.1.10.442
3pefNAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase/0.442
3slkNDPPolyketide synthase extender module 2/0.442
3wagTYDGlycosyltransferase/0.442
4bbyFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.442
4d86ADPPoly [ADP-ribose] polymerase 142.4.2.300.442
4dqh017Gag-Pol polyprotein/0.442
4kqwNAPKetol-acid reductoisomerase (NADP(+))/0.442
4xguADPPutative pachytene checkpoint protein 2/0.442
1c6yMK1Protease/0.441
1eq2NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.441
1h74AGSHomoserine kinase2.7.1.390.441
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.441
1i6xCMPcAMP-activated global transcriptional regulator CRP/0.441
1iy8NADLevodione reductase/0.441
1j3kNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
1okkGCPSignal recognition particle protein/0.441
1okkGCPSignal recognition particle receptor FtsY/0.441
1pr9NAPL-xylulose reductase1.1.1.100.441
1qy5NECEndoplasmin/0.441
1rfuADPPyridoxal kinase2.7.1.350.441
1rj9GCPSignal recognition particle receptor FtsY/0.441
1t7j478Gag-Pol polyprotein3.4.23.160.441
1yreCOAUncharacterized protein/0.441
2bi7FADUDP-galactopyranose mutase5.4.99.90.441
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2cduFADNADH oxidase/0.441
2emuSAHDiphthine synthase/0.441
2g226IGRenin3.4.23.150.441
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.441
2gevCOKPantothenate kinase2.7.1.330.441
2gsdNADFormate dehydrogenase/0.441
2q7vFADThioredoxin reductase/0.441
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.441
2xvfFADPutative flavin-containing monooxygenase/0.441
3bw4FMNPutative 2-nitropropane dioxygenase/0.441
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3lzxFADFerredoxin--NADP reductase 21.18.1.20.441
3mvqNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.441
3mw9NAIGlutamate dehydrogenase 1, mitochondrial1.4.1.30.441
3nxxNDPDihydrofolate reductase1.5.1.30.441
3qdlFMNOxygen-insensitive NADPH nitroreductase/0.441
3umsGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.441
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.441
4esoNAPPutative oxidoreductase/0.441
4f9fGDPPutative glycosyltransferase/0.441
4gh5NADShort-chain dehydrogenase/reductase SDR/0.441
4kvzSAHPtnL protein/0.441
4q1w017Gag-Pol polyprotein3.4.23.160.441
4u2lSFDCholesterol oxidase1.1.3.60.441
4ubvCOASteroid 3-ketoacyl-CoA thiolase/0.441
4xqcNADHomospermidine synthase2.5.1.440.441
5e5h0T1Succinyl-CoA:acetate CoA-transferase/0.441
1bil0IURenin3.4.23.150.440
1d4dFADFumarate reductase flavoprotein subunit1.3.5.40.440
1hdoNAPFlavin reductase (NADPH)/0.440
1hf3NADAlcohol dehydrogenase E chain1.1.1.10.440
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.440
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.440
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2ejvNADL-threonine 3-dehydrogenase/0.440
2ggqTTPDual sugar-1-phosphate nucleotidylyltransferase/0.440
2i4qUA4Renin3.4.23.150.440
2px5SAHGenome polyprotein2.7.7.480.440
2x7hPFNProstaglandin reductase 310.440
2xpuTDCTetracycline repressor protein class D/0.440
2yoj8Y6Genome polyprotein2.7.7.480.440
2yy7NADL-threonine dehydrogenase/0.440
3autNAIGlucose 1-dehydrogenase 41.1.1.470.440
3biy01KHistone acetyltransferase p300/0.440
3c3nFMNDihydroorotate dehydrogenase (fumarate)1.3.98.10.440
3docNADGlyceraldehyde-3-phosphate dehydrogenase/0.440
3ijoB4DGlutamate receptor 2/0.440
3likEEGMacrophage metalloelastase3.4.24.650.440
3ox4NADAlcohol dehydrogenase 21.1.1.10.440
4a0rDTBBifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial6.3.3.30.440
4dlbNADS-(hydroxymethyl)glutathione dehydrogenase/0.440
4emtC2EStimulator of interferon genes protein/0.440
4ew3DXZTrifunctional purine biosynthetic protein adenosine-32.1.2.20.440
4f6rGDPTubulin beta chain/0.440
4lj6ACPChaperone protein ClpB/0.440
4r81FMNPredicted NADH dehydrogenase/0.440
4xrgNADHomospermidine synthase2.5.1.440.440
4xwzFADFructosyl amine:oxygen oxidoreductase/0.440
5dbgNADIridoid synthase1.3.1.990.440
5irnADPNucleotide binding oligomerization domain containing 2/0.440
4xnw2IDP2Y purinoceptor 1/0.440