sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1ix1 | BB2 | Peptide deformylase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1ix1 | BB2 | Peptide deformylase | / | 1.000 | |
| 3pn4 | BB2 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.618 | |
| 2ew5 | Y12 | Peptide deformylase | / | 0.591 | |
| 3m6p | BB2 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.591 | |
| 3o3j | BB4 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.577 | |
| 2ew6 | Y13 | Peptide deformylase | / | 0.569 | |
| 1ws1 | BB2 | Peptide deformylase 1 | / | 0.558 | |
| 4e9a | QAP | Peptide deformylase | / | 0.558 | |
| 1s17 | GNR | Peptide deformylase | / | 0.556 | |
| 3u04 | BB2 | Peptide deformylase | / | 0.556 | |
| 1lru | BB2 | Peptide deformylase | 3.5.1.88 | 0.545 | |
| 1lry | BB2 | Peptide deformylase | / | 0.543 | |
| 1g27 | BB1 | Peptide deformylase | 3.5.1.88 | 0.531 | |
| 1g2a | BB2 | Peptide deformylase | 3.5.1.88 | 0.511 | |
| 3e3u | NVC | Peptide deformylase | 3.5.1.88 | 0.506 | |
| 4e9b | BB2 | Peptide deformylase | / | 0.504 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.497 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 3m6r | BB2 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.494 | |
| 3e8x | NAP | BH1520 protein | / | 0.493 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.492 | |
| 3uwb | BB2 | RIIA-RIIB membrane-associated protein | / | 0.491 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.489 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.489 | |
| 1sbr | VIB | Putative HMP/thiamine-binding protein YkoF | / | 0.488 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.488 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.487 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.481 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.480 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.480 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.480 | |
| 4u8i | FDA | UDP-galactopyranose mutase | / | 0.478 | |
| 3g5k | BB2 | Peptide deformylase, mitochondrial | 3.5.1.88 | 0.477 | |
| 2ejz | SAH | Diphthine synthase | / | 0.476 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.476 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.476 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.475 | |
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.474 | |
| 2xik | J60 | Serine/threonine-protein kinase 25 | 2.7.11.1 | 0.474 | |
| 2zsh | GA3 | Gibberellin receptor GID1A | 3 | 0.474 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.473 | |
| 3ppo | DCK | Glycine betaine/carnitine/choline-binding protein OpuCC | / | 0.473 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.472 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.472 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.472 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.471 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.470 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.470 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.469 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.469 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.469 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.469 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.468 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.468 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.467 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.467 | |
| 4je7 | BB2 | Peptide deformylase 1A, chloroplastic/mitochondrial | 3.5.1.88 | 0.467 | |
| 2e17 | SAH | Diphthine synthase | / | 0.466 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.466 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.466 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.465 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.465 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.465 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.464 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.464 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.464 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.463 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.463 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.463 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.462 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.462 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.462 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 3svj | 4LI | Peptide deformylase | / | 0.462 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.462 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.461 | |
| 2vrb | NAP | Triphenylmethane reductase | / | 0.461 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.461 | |
| 4boe | CLR | Japanin | / | 0.461 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.461 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.460 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.460 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.460 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.460 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.460 | |
| 4u8j | FDA | UDP-galactopyranose mutase | / | 0.460 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.459 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 2e8r | SAH | Diphthine synthase | / | 0.459 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.459 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.459 | |
| 3rdq | DTB | Streptavidin | / | 0.459 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.459 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.458 | |
| 1ve3 | SAM | Uncharacterized protein | / | 0.458 | |
| 2aie | SB9 | Peptide deformylase | / | 0.458 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.458 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.458 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1l4m | NCN | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | 2.4.2.21 | 0.457 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.457 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 4eub | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.457 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.457 | |
| 1i2l | DCS | Aminodeoxychorismate lyase | 4.1.3.38 | 0.456 | |
| 1lqy | BB2 | Peptide deformylase 2 | 3.5.1.88 | 0.456 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.456 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.456 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.456 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.456 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.456 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.456 | |
| 4prx | ADP | DNA gyrase subunit B | / | 0.456 | |
| 4rvn | COA | Phenylacetate-coenzyme A ligase | / | 0.456 | |
| 4udr | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.456 | |
| 5a3b | APR | SIR2 family protein | / | 0.456 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.455 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.455 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.455 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.455 | |
| 4f65 | 0S9 | Fibroblast growth factor receptor 1 | / | 0.455 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.455 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.454 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.454 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.454 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.454 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 3hy7 | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.454 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.454 | |
| 3mje | NDP | AmphB | / | 0.454 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.454 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 4ie6 | UN9 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.454 | |
| 4m5p | FMN | NADPH dehydrogenase | / | 0.454 | |
| 4r3a | RBF | Blue-light-activated histidine kinase 2 | 2.7.13.3 | 0.454 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.454 | |
| 1aj2 | 2PH | Dihydropteroate synthase | / | 0.453 | |
| 1d7a | AIR | N5-carboxyaminoimidazole ribonucleotide mutase | / | 0.453 | |
| 1h65 | GDP | Translocase of chloroplast 34 | 3.6.5 | 0.453 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.453 | |
| 2z6r | SAH | Diphthine synthase | / | 0.453 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.453 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.453 | |
| 3eon | 341 | Glutaryl-CoA dehydrogenase | / | 0.453 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.453 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.453 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.453 | |
| 4eox | 0S5 | Peptide deformylase | / | 0.453 | |
| 4qec | NAP | ElxO | / | 0.453 | |
| 4qys | PLR | Tryptophan synthase beta chain 2 | 4.2.1.20 | 0.453 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.452 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.452 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 1u2y | GOX | Pancreatic alpha-amylase | / | 0.452 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.452 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.452 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.452 | |
| 2os3 | BB2 | Peptide deformylase | / | 0.452 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.452 | |
| 2zsi | GA4 | Gibberellin receptor GID1A | 3 | 0.452 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3nx2 | FER | Ferulic acid decarboxylase | / | 0.452 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3u7k | MDB | Peptide deformylase | / | 0.452 | |
| 4gyy | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.452 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.452 | |
| 4yek | THM | Thymidine phosphorylase | / | 0.452 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.452 | |
| 5dp2 | NAP | CurF | / | 0.452 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.451 | |
| 1emd | NAD | Malate dehydrogenase | / | 0.451 | |
| 1szj | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.451 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.451 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.451 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.451 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 2ek2 | SAH | Diphthine synthase | / | 0.451 | |
| 2h23 | SAH | Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic | 2.1.1.127 | 0.451 | |
| 2hut | SAH | Diphthine synthase | / | 0.451 | |
| 2web | PP4 | Penicillopepsin-1 | 3.4.23.20 | 0.451 | |
| 3anx | MTA | Polyamine aminopropyltransferase | / | 0.451 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.451 | |
| 3ko8 | NAD | NAD-dependent epimerase/dehydratase | / | 0.451 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 3rfx | NAD | Uronate dehydrogenase | / | 0.451 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.451 | |
| 4bqr | IBH | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.451 | |
| 4e5p | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.451 | |
| 4yp6 | NAP | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.451 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.451 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.450 | |
| 1jha | AAM | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | 2.4.2.21 | 0.450 | |
| 1kw9 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.450 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 2emu | SAH | Diphthine synthase | / | 0.450 | |
| 2en5 | SAH | Diphthine synthase | / | 0.450 | |
| 2os1 | BB2 | Peptide deformylase | / | 0.450 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.450 | |
| 3da2 | 4MD | Carbonic anhydrase 13 | 4.2.1.1 | 0.450 | |
| 3w77 | FMN | FMN-dependent NADH-azoreductase | / | 0.450 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 4pan | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.450 | |
| 4yfy | 1YJ | VioF | / | 0.450 | |
| 1l4g | NCN | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | 2.4.2.21 | 0.449 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.449 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.449 | |
| 3wag | TYD | Glycosyltransferase | / | 0.449 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4h4z | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.449 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 1gc5 | ADP | ADP-dependent glucokinase | 2.7.1.147 | 0.448 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1zdw | FLV | Prenyltransferase | / | 0.448 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.448 | |
| 2e15 | SAH | Diphthine synthase | / | 0.448 | |
| 2ji9 | TPW | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.448 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.448 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.448 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.448 | |
| 3qgi | 33F | Genome polyprotein | 2.7.7.48 | 0.448 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.448 | |
| 3u7l | UDB | Peptide deformylase | / | 0.448 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.448 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.448 | |
| 4f0e | 0RU | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.448 | |
| 4ros | APR | Malate dehydrogenase | / | 0.448 | |
| 4zu4 | 4TG | WxcM-like protein | / | 0.448 | |
| 5ahs | COA | Acyl-CoA dehydrogenase | / | 0.448 | |
| 1dgm | ADN | Adenosine kinase | 2.7.1.20 | 0.447 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.447 | |
| 1u33 | LM2 | Pancreatic alpha-amylase | / | 0.447 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.447 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.447 | |
| 2dv7 | SAH | Diphthine synthase | / | 0.447 | |
| 2g2z | COZ | Malonyl CoA-acyl carrier protein transacylase | 2.3.1.39 | 0.447 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.447 | |
| 3qiz | QI2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.447 | |
| 3w5h | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.447 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.447 | |
| 1f28 | UMP | Thymidylate synthase | 2.1.1.45 | 0.446 | |
| 1okl | MNS | Carbonic anhydrase 2 | 4.2.1.1 | 0.446 | |
| 2ai7 | SB7 | Peptide deformylase | / | 0.446 | |
| 2j2p | SC2 | Ficolin-2 | / | 0.446 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.446 | |
| 2q29 | ACO | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.446 | |
| 2uzu | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.446 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.446 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.446 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.446 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.446 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.446 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.446 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA2 | 3.6.3 | 0.446 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA1 | / | 0.446 | |
| 5fs7 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.446 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1ja0 | NAP | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 1l4f | NCN | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | 2.4.2.21 | 0.445 | |
| 1p84 | UQ6 | Cytochrome b | / | 0.445 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.445 | |
| 2op1 | 8PC | Enoyl-ACP reductase | / | 0.445 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.445 | |
| 3tm4 | SAM | Uncharacterized protein | / | 0.445 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.445 | |
| 4kug | NAD | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.445 | |
| 1m8g | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.444 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.444 | |
| 2eh2 | SAH | Diphthine synthase | / | 0.444 | |
| 2jd1 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.444 | |
| 2owk | SAH | Diphthine synthase | / | 0.444 | |
| 2p6l | SAH | Diphthine synthase | / | 0.444 | |
| 2uyw | BTN | Avd protein | / | 0.444 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3b9x | NOS | Pyrimidine-specific ribonucleoside hydrolase RihB | 3.2.2.8 | 0.444 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.444 | |
| 3ewk | FAD | Sensory box histidine kinase/response regulator | / | 0.444 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.444 | |
| 3gvi | ADP | Malate dehydrogenase | / | 0.444 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.444 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.444 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.444 | |
| 3ls8 | AJZ | Phosphatidylinositol 3-kinase catalytic subunit type 3 | 2.7.1.137 | 0.444 | |
| 3zxz | KRW | Hepatocyte growth factor receptor | 2.7.10.1 | 0.444 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.444 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.444 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.444 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.444 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.444 | |
| 4y35 | F90 | Endothiapepsin | 3.4.23.22 | 0.444 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 1gpe | FAD | Glucose oxidase | 1.1.3.4 | 0.443 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.443 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.443 | |
| 1l4h | NCN | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | 2.4.2.21 | 0.443 | |
| 1mr9 | ACO | Streptogramin A acetyltransferase | 2.3.1 | 0.443 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.443 | |
| 1piw | NAP | NADP-dependent alcohol dehydrogenase 6 | 1.1.1.2 | 0.443 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.443 | |
| 2xfs | J01 | Uncharacterized protein | / | 0.443 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.443 | |
| 2zyn | BCD | Periplasmic binding protein | / | 0.443 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.443 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.443 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.443 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.443 | |
| 4l8u | 9AZ | Serum albumin | / | 0.443 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.443 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.443 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1dlj | UGA | UDP-glucose 6-dehydrogenase | / | 0.442 | |
| 1n3r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.442 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1yjq | NAP | 2-dehydropantoate 2-reductase | 1.1.1.169 | 0.442 | |
| 2cft | PLP | Pyridoxal phosphate phosphatase | / | 0.442 | |
| 2el0 | SAH | Diphthine synthase | / | 0.442 | |
| 2ele | SAH | Diphthine synthase | / | 0.442 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.442 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.442 | |
| 2xda | JPS | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.442 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.442 | |
| 3ox4 | NAD | Alcohol dehydrogenase 2 | 1.1.1.1 | 0.442 | |
| 3q3c | NAD | NAD-dependent L-serine dehydrogenase | / | 0.442 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.442 | |
| 3wo0 | ADP | Alanine--anticapsin ligase | / | 0.442 | |
| 3zly | YSO | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.442 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4ho6 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.442 | |
| 4jb1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.442 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 4mv4 | ACP | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.442 | |
| 3pbl | ETQ | D(3) dopamine receptor | / | 0.442 | |
| 1bwk | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.441 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.441 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.441 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.441 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.441 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.441 | |
| 1zoy | UQ1 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | 1.3.5.1 | 0.441 | |
| 1zoy | UQ1 | Succinate dehydrogenase cytochrome b560 subunit, mitochondrial | / | 0.441 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 2dxx | SAH | Diphthine synthase | / | 0.441 | |
| 2rg5 | 279 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 2rir | NAP | Dipicolinate synthase subunit A | / | 0.441 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.441 | |
| 2y05 | RAL | Prostaglandin reductase 1 | / | 0.441 | |
| 2zz0 | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.441 | |
| 3awh | FMN | FMN-binding protein | / | 0.441 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.441 | |
| 3pdq | KC6 | Lysine-specific demethylase 4A | 1.14.11 | 0.441 | |
| 3qwp | SAM | Histone-lysine N-methyltransferase SMYD3 | 2.1.1.43 | 0.441 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.441 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4e2d | FMN | Dehydrogenase | / | 0.441 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.441 | |
| 4kp5 | E1F | Carbonic anhydrase 12 | 4.2.1.1 | 0.441 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.441 | |
| 4pzk | SAH | Putative tRNA (cytidine(34)-2'-O)-methyltransferase | / | 0.441 | |
| 4rr8 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.441 | |
| 4xcz | FON | Qdtf | / | 0.441 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1hdo | NAP | Flavin reductase (NADPH) | / | 0.440 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.440 | |
| 1jmh | UMP | Thymidylate synthase | / | 0.440 | |
| 1kbi | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.440 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.440 | |
| 2dsh | SAH | Diphthine synthase | / | 0.440 | |
| 2dxv | SAH | Diphthine synthase | / | 0.440 | |
| 2ehl | SAH | Diphthine synthase | / | 0.440 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.440 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.440 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.440 | |
| 2uz2 | BTN | Avd protein | / | 0.440 | |
| 3dh7 | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.440 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.440 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.440 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.440 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.440 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 3zhq | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.440 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.440 | |
| 4jic | FMN | GTN Reductase | / | 0.440 | |
| 4kik | KSA | Inhibitor of nuclear factor kappa-B kinase subunit beta | 2.7.11.10 | 0.440 | |
| 4pd6 | URI | Nucleoside permease | / | 0.440 | |
| 4tmc | FMN | Old yellow enzyme | / | 0.440 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.440 |