sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4de0 | 0JB | Beta-lactamase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4de0 | 0JB | Beta-lactamase | / | 1.000 | |
| 4ddy | DN6 | Beta-lactamase | / | 0.633 | |
| 3hlw | CE3 | Beta-lactamase | / | 0.629 | |
| 4de2 | DN3 | Beta-lactamase | / | 0.611 | |
| 4de1 | 0J6 | Beta-lactamase | / | 0.600 | |
| 4de3 | DN8 | Beta-lactamase | / | 0.591 | |
| 3q1f | YPP | Beta-lactamase | / | 0.523 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.498 | |
| 3d3x | ARG_ILE_MET_GLU_NH2 | Type E botulinum toxin | / | 0.495 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.494 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.490 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.490 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.489 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.489 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.488 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.488 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.486 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.485 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.485 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.484 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.483 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.483 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.483 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.482 | |
| 3cwq | ADP | ParA family chromosome partitioning protein | / | 0.481 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.480 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.480 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.480 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.480 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.479 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.478 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.478 | |
| 2xx9 | 1NF | Glutamate receptor 2 | / | 0.478 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.478 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.477 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.477 | |
| 3zvm | ADP | Bifunctional polynucleotide phosphatase/kinase | 2.7.1.78 | 0.477 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.477 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.477 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.476 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.476 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.475 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.475 | |
| 4nwz | FAD | FAD-dependent pyridine nucleotide-disulfide oxidoreductase | / | 0.475 | |
| 4u0m | ATP | Cyclic GMP-AMP synthase | / | 0.475 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.474 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.474 | |
| 3wid | NAP | Glucose 1-dehydrogenase | / | 0.474 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.474 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.473 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.473 | |
| 1c9k | 5GP | Bifunctional adenosylcobalamin biosynthesis protein CobU | / | 0.472 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.472 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.471 | |
| 2fut | H1S | Heparin and heparin-sulfate lyase | / | 0.471 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.471 | |
| 3int | FDA | UDP-galactopyranose mutase | 5.4.99.9 | 0.471 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.471 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.471 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.471 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.470 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.470 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.470 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.470 | |
| 3a3g | DLZ | Lumazine protein | / | 0.470 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.470 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.470 | |
| 4usr | FAD | Monooxygenase | / | 0.470 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.470 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.470 | |
| 1d0l | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.469 | |
| 2pj4 | 414 | Carboxypeptidase B | / | 0.469 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.469 | |
| 3cls | FAD | Electron transfer flavoprotein subunit alpha | / | 0.469 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.469 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.468 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.468 | |
| 2ilv | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.468 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.468 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.468 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.468 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.467 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.467 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.467 | |
| 3gst | GPR | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.467 | |
| 3ieu | GDP | GTPase Era | / | 0.467 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.467 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.467 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.467 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.466 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.466 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.466 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.466 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.466 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.465 | |
| 1szf | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.465 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.465 | |
| 4dd8 | BAT | Disintegrin and metalloproteinase domain-containing protein 8 | 3.4.24 | 0.465 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.464 | |
| 3f3s | NAD | Lambda-crystallin homolog | / | 0.464 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.464 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE26 | / | 0.464 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE27 | / | 0.464 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.464 | |
| 1zio | AP5 | Adenylate kinase | / | 0.463 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.463 | |
| 2rgo | FAD | Alpha-Glycerophosphate Oxidase | / | 0.463 | |
| 2zr9 | DTP | Protein RecA | / | 0.463 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.463 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.463 | |
| 3pi5 | 3P5 | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 4kvm | SER_ALA_SER_GLU_1XE | N-terminal acetyltransferase A complex catalytic subunit ard1 | 2.3.1.88 | 0.463 | |
| 4p63 | NAD | Probable deoxyhypusine synthase | 2.5.1.46 | 0.463 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.462 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.462 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.462 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.462 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.462 | |
| 3dk9 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.462 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.462 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.462 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.462 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.462 | |
| 4jay | NAP | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.462 | |
| 1fcb | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.461 | |
| 2b8l | 5HA | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 2z1m | NDP | GDP-mannose 4,6-dehydratase | / | 0.461 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.461 | |
| 4dpf | 0LG | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.461 | |
| 1dor | FMN | Dihydroorotate dehydrogenase A (fumarate) | 1.3.98.1 | 0.460 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.460 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.460 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.460 | |
| 2xy3 | DUP | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.460 | |
| 3lzs | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.460 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.460 | |
| 5f8e | SAH | Possible transcriptional regulatory protein | / | 0.460 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.459 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.459 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.459 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.459 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 4k9h | 1QU | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.458 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.458 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.458 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.458 | |
| 3e23 | SAM | Uncharacterized protein | / | 0.458 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.458 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.458 | |
| 4fkz | UD1 | UDP-N-acetylglucosamine 2-epimerase | 5.1.3.14 | 0.458 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.458 | |
| 5ahs | FAD | Acyl-CoA dehydrogenase | / | 0.458 | |
| 5c4n | NAP | Precorrin-6A reductase | 1.3.1.54 | 0.458 | |
| 1bdb | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | / | 0.457 | |
| 1gsn | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.457 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.457 | |
| 2jkv | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.457 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.457 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.457 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.457 | |
| 3uay | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.457 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.457 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.457 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.457 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.456 | |
| 2b4r | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.456 | |
| 2j3n | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.456 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.456 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.456 | |
| 5e7o | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.456 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.455 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1hnc | GDN | Glutathione S-transferase Mu 2 | 2.5.1.18 | 0.455 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.455 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.455 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.455 | |
| 2iwh | ANP | Elongation factor 3A | / | 0.455 | |
| 2zz0 | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.455 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.455 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.455 | |
| 3uko | NAD | Alcohol dehydrogenase class-3 | / | 0.455 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.455 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.455 | |
| 4i9h | 1E4 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.455 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.455 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.454 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.454 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.454 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.454 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.454 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.454 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.454 | |
| 3bgx | TMP | Thymidylate synthase | / | 0.454 | |
| 3bmo | NAP | Pteridine reductase | / | 0.454 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.454 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.454 | |
| 4dri | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.454 | |
| 4dri | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.454 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.454 | |
| 5fs7 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.454 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.454 | |
| 1d0m | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.453 | |
| 1kbi | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.453 | |
| 1obb | NAD | Alpha-glucosidase | 3.2.1.20 | 0.453 | |
| 1uxy | EPU | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.453 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.453 | |
| 2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 2ylr | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.453 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.453 | |
| 3axk | NDP | Ribulose bisphosphate carboxylase large chain | 4.1.1.39 | 0.453 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.453 | |
| 3cis | ATP | Universal stress protein Rv2623 | / | 0.453 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.453 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 4f5y | C2E | Stimulator of interferon genes protein | / | 0.453 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.453 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.453 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.453 | |
| 4ock | ANP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.453 | |
| 1l2s | STC | Beta-lactamase | 3.5.2.6 | 0.452 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.452 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.452 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.452 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.452 | |
| 2qjo | NAD | Bifunctional NMN adenylyltransferase/Nudix hydrolase | 2.7.7.1 | 0.452 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.452 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.452 | |
| 3oix | FMN | Dihydroorotate dehydrogenase | / | 0.452 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.452 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.452 | |
| 5ftf | ADP | TPR domain protein | / | 0.452 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.451 | |
| 1zk7 | FAD | Mercuric reductase | 1.16.1.1 | 0.451 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.451 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.451 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.451 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.451 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.451 | |
| 3sgl | FAD | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | / | 0.451 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.451 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.451 | |
| 4kgk | GTP | Uncharacterized protein | / | 0.451 | |
| 5dp2 | NAP | CurF | / | 0.451 | |
| 5er0 | FAD | Uncharacterized NAD(FAD)-dependent dehydrogenase | / | 0.451 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.450 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.450 | |
| 1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.450 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.450 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.450 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.450 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.450 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.450 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 5af7 | FAD | Acyl-CoA dehydrogenase | / | 0.450 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 2fxf | ACO | Diamine acetyltransferase 1 | / | 0.449 | |
| 2gz7 | D3F | Orf1a polyprotein | / | 0.449 | |
| 2irz | I02 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.449 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.449 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.449 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.449 | |
| 2djl | FMN | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.448 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.448 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 3dk8 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.448 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.448 | |
| 3qvr | FAD | Glucose oxidase | 1.1.3.4 | 0.448 | |
| 4gid | 0GH | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.448 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.448 | |
| 4qbg | AP5 | Adenylate kinase | / | 0.448 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.448 | |
| 1jkx | 138 | Phosphoribosylglycinamide formyltransferase | / | 0.447 | |
| 1ohh | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.447 | |
| 1ohh | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.447 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.447 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.447 | |
| 3iwj | NAD | Aminoaldehyde dehydrogenase | / | 0.447 | |
| 3r96 | ACO | MccE protein | / | 0.447 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 4i9n | 1E5 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.447 | |
| 4m5p | FMN | NADPH dehydrogenase | / | 0.447 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.447 | |
| 4rvf | TYD | D-mycarose 3-C-methyltransferase | / | 0.447 | |
| 1ty9 | FMN | Phenazine biosynthesis protein PhzG | 1.4 | 0.446 | |
| 1w4x | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.446 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.446 | |
| 2v7q | ATP | ATP synthase subunit alpha, mitochondrial | / | 0.446 | |
| 2v7q | ATP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.446 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.446 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.446 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.446 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.446 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.445 | |
| 1d4d | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.445 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1njf | ADP | DNA polymerase III subunit tau | 2.7.7.7 | 0.445 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.445 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.445 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.445 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.445 | |
| 2ex1 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.445 | |
| 2ome | NAD | C-terminal-binding protein 2 | / | 0.445 | |
| 2p0r | LEU_LEU_ACE_AR7 | Calpain-9 | / | 0.445 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.445 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.445 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.445 | |
| 3kkz | SAM | Uncharacterized protein | / | 0.445 | |
| 3ksq | Z96 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.445 | |
| 3v2u | ATP | Protein GAL3 | / | 0.445 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.445 | |
| 4c13 | UML | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | / | 0.445 | |
| 4nau | AGS | Phosphopantetheine adenylyltransferase | / | 0.445 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.445 | |
| 4ntd | FAD | Thioredoxin reductase | / | 0.445 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.445 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.445 | |
| 1hku | NAD | C-terminal-binding protein 1 | 1.1.1 | 0.444 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.444 | |
| 1udy | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.444 | |
| 1vjt | NAD | Alpha-glucosidase, putative | / | 0.444 | |
| 2g20 | L1A | Renin | 3.4.23.15 | 0.444 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.444 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.444 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.444 | |
| 2vij | C44 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 2viy | VG3 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 2vou | FAD | 2,6-dihydroxypyridine 3-monooxygenase | 1.14.13.10 | 0.444 | |
| 2xvh | NAP | Putative flavin-containing monooxygenase | / | 0.444 | |
| 2yd0 | BES | Endoplasmic reticulum aminopeptidase 1 | 3.4.11 | 0.444 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 3axb | FAD | Putative oxidoreductase | / | 0.444 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.444 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.444 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.444 | |
| 4lol | 1YE | Stimulator of interferon genes protein | / | 0.444 | |
| 1cdo | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.443 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.443 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.443 | |
| 2b4y | APR | NAD-dependent protein deacylase sirtuin-5, mitochondrial | / | 0.443 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.443 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.443 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.443 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.443 | |
| 2wez | ZYE | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 2z54 | AB1 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.443 | |
| 3c3e | GDP | 2-phospho-L-lactate transferase | / | 0.443 | |
| 3dgz | FAD | Thioredoxin reductase 2, mitochondrial | 1.8.1.9 | 0.443 | |
| 3eks | CY9 | Actin-5C | / | 0.443 | |
| 3em3 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 3fst | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.443 | |
| 3g0b | T22 | Dipeptidyl peptidase 4 | / | 0.443 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.443 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.443 | |
| 4ef9 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.443 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.443 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.443 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.443 | |
| 4jld | ADP | Adenylate kinase | / | 0.443 | |
| 5eyu | NAD | Betaine-aldehyde dehydrogenase | / | 0.443 | |
| 1qo8 | FAD | Fumarate reductase flavoprotein subunit | / | 0.442 | |
| 1zp4 | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.442 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.442 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.442 | |
| 2hpv | FMN | FMN-dependent NADH-azoreductase | 1.7 | 0.442 | |
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.442 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.442 | |
| 3ahn | 3A1 | Oligopeptidase | / | 0.442 | |
| 3djg | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.442 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.442 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 4c4o | NAD | SADH | / | 0.442 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.442 | |
| 4z5w | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.442 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.441 | |
| 1kev | NDP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.441 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.441 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.441 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.441 | |
| 2f3f | AXF | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2fre | FMN | NAD(P)H-flavin oxidoreductase | / | 0.441 | |
| 2hm1 | LIQ | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2i7n | ACO | Pantothenate kinase 1 | 2.7.1.33 | 0.441 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.441 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.441 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 3bj7 | COA | Diamine acetyltransferase 1 | / | 0.441 | |
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 | / | 0.441 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.441 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.441 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3o0o | 5AD | Vitamin B12-dependent ribonucleotide reductase | / | 0.441 | |
| 3qdl | FMN | Oxygen-insensitive NADPH nitroreductase | / | 0.441 | |
| 3s87 | ADP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.441 | |
| 4blr | UTP | NTPase P4 | / | 0.441 | |
| 4f9g | C2E | Stimulator of interferon genes protein | / | 0.441 | |
| 4fdu | IHS | Putative multiple inositol polyphosphate histidine phosphatase 1 | / | 0.441 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.441 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.440 | |
| 1tsx | UMP | Thymidylate synthase | / | 0.440 | |
| 1v0j | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.440 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.440 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.440 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.440 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.440 | |
| 2gst | GPS | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.440 | |
| 2is0 | I03 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.440 | |
| 2wf2 | ZY2 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3gwd | NAP | Cyclohexanone monooxygenase | / | 0.440 | |
| 3lb8 | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.440 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.440 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.440 | |
| 4d03 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.440 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.440 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.440 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.440 |