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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3ojiPYVAbscisic acid receptor PYL3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3ojiPYVAbscisic acid receptor PYL3/1.000
3nj0PYVAbscisic acid receptor PYL2/0.585
3nmpPYVAbscisic acid receptor PYL2/0.568
3ns2PYVAbscisic acid receptor PYL2/0.568
3nr4PYVAbscisic acid receptor PYL2/0.556
3nmhPYVAbscisic acid receptor PYL2/0.542
3nmnPYVAbscisic acid receptor PYL1/0.541
3kb0A8SAbscisic acid receptor PYL2/0.537
3ujlA8SAbscisic acid receptor PYL2/0.535
4dscA8SAbscisic acid receptor PYL3/0.531
3kdiA8SAbscisic acid receptor PYL2/0.527
4lg5A1OAbscisic acid receptor PYL2/0.523
3njoP2MAbscisic acid receptor PYR1/0.522
2zbaZBATrichothecene 3-O-acetyltransferase/0.517
3zvuA8SAbscisic acid receptor PYR1/0.512
4ds8A8SAbscisic acid receptor PYL3/0.508
4oicA8SBet v I allergen-like/0.508
2a1nCAMCamphor 5-monooxygenase1.14.15.10.505
3kb3A8SAbscisic acid receptor PYL2/0.498
4lgaA2OAbscisic acid receptor PYL2/0.494
1bwsNDPGDP-L-fucose synthase/0.493
4la7A1OAbscisic acid receptor PYL2/0.493
2qbnCAMCamphor 5-monooxygenase1.14.15.10.491
2feuCAMCamphor 5-monooxygenase1.14.15.10.490
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.490
6cp4CAMCamphor 5-monooxygenase1.14.15.10.490
2qblCAMCamphor 5-monooxygenase1.14.15.10.489
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.489
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.487
1s4dSAHUroporphyrinogen-III C-methyltransferase2.1.1.1070.486
3fwjCAMCamphor 5-monooxygenase1.14.15.10.486
1u3dFADCryptochrome-1/0.485
3fwfCAMCamphor 5-monooxygenase1.14.15.10.484
3nefPYVAbscisic acid receptor PYL1/0.483
1hfqMOTDihydrofolate reductase1.5.1.30.482
4gk2L66Ephrin type-A receptor 32.7.10.10.482
2gjlFMNNitronate monooxygenase1.13.12.160.481
4kkyCAMCamphor 5-monooxygenase1.14.15.10.481
5d1bTSNHistone deacetylase 83.5.1.980.481
1t85CAMCamphor 5-monooxygenase1.14.15.10.480
1t88CAMCamphor 5-monooxygenase1.14.15.10.480
1yetGDMHeat shock protein HSP 90-alpha/0.480
2z97CAMCamphor 5-monooxygenase1.14.15.10.480
3fp0FP015-O-acetyltransferase/0.480
4j6bPLOCytochrome P450 monooxygenase/0.480
1k6cMK1Gag-Pol polyprotein3.4.23.160.479
3l63CAMCamphor 5-monooxygenase1.14.15.10.479
4jx1CAHCamphor 5-monooxygenase1.14.15.10.479
1t86CAMCamphor 5-monooxygenase1.14.15.10.478
2cchATPCyclin-dependent kinase 22.7.11.220.478
2vwx7X4Ephrin type-B receptor 42.7.10.10.478
2zaxCAMCamphor 5-monooxygenase1.14.15.10.478
2vkeTACTetracycline repressor protein class D/0.477
3t3r9PLCytochrome P450 2A61.14.130.477
1t87CAMCamphor 5-monooxygenase1.14.15.10.476
2uxhQUEHTH-type transcriptional regulator TtgR/0.476
3wrmCAMCamphor 5-monooxygenase1.14.15.10.476
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.476
4mv4ACPBiotin carboxylase6.3.4.140.476
1nooCAHCamphor 5-monooxygenase1.14.15.10.475
2qboCAMCamphor 5-monooxygenase1.14.15.10.475
3fwiCAMCamphor 5-monooxygenase1.14.15.10.475
3wrjCAMCamphor 5-monooxygenase1.14.15.10.475
4l4fCAMCamphor 5-monooxygenase1.14.15.10.475
4x5gFOLDihydrofolate reductase1.5.1.30.475
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.474
4eji0QACytochrome P450 2A131.14.14.10.474
4ek1CAMCamphor 5-monooxygenase1.14.15.10.474
3p62FMNPentaerythritol tetranitrate reductase/0.473
1n5vNOMActVA 6 protein/0.472
2cy0NAPShikimate dehydrogenase (NADP(+))/0.472
2rkvZBATrichothecene 3-O-acetyltransferase/0.472
3w9rA8SAbscisic acid receptor PYL9/0.472
4enhFVXCholesterol 24-hydroxylase/0.472
1dz4CAMCamphor 5-monooxygenase1.14.15.10.471
1foaUD1Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase2.4.1.1010.471
1pl8NADSorbitol dehydrogenase1.1.1.140.471
3qj5022Alcohol dehydrogenase class-31.1.1.10.471
3qakUKAAdenosine receptor A2a/0.471
1i59ANPChemotaxis protein CheA2.7.13.30.470
1yrdCAMCamphor 5-monooxygenase1.14.15.10.470
3fwgCAMCamphor 5-monooxygenase1.14.15.10.470
3kdjA8SAbscisic acid receptor PYL1/0.470
4bb3KKAIsopenicillin N synthase1.21.3.10.470
4hnc0UTMandelate racemase/0.470
1dz6CAMCamphor 5-monooxygenase1.14.15.10.469
1t13INI6,7-dimethyl-8-ribityllumazine synthase 2/0.469
1uzwCDHIsopenicillin N synthase1.21.3.10.469
2v59LZKBiotin carboxylase6.3.4.140.469
2w6oOA3Biotin carboxylase6.3.4.140.469
4klaCHDFerrochelatase, mitochondrial4.99.1.10.469
2m56CAMCamphor 5-monooxygenase1.14.15.10.468
3bgrT27Gag-Pol polyprotein2.7.7.490.468
3dhaC6LN-acyl homoserine lactonase AiiA3.1.1.810.468
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.468
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.468
1e7qNAPGDP-L-fucose synthase/0.467
1iwiCAMCamphor 5-monooxygenase1.14.15.10.467
1yrcCAMCamphor 5-monooxygenase1.14.15.10.467
3junAJDPhenazine biosynthesis protein A/B/0.467
3njoPYVAbscisic acid receptor PYR1/0.467
3qlzQLZUncharacterized protein/0.467
3t5iSER_SER_CMT_FARRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.467
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.467
4ihl1F514-3-3 protein zeta/delta/0.467
1rx8FOLDihydrofolate reductase1.5.1.30.466
1toiHCIAspartate aminotransferase2.6.1.10.466
1uyuCAMCamphor 5-monooxygenase1.14.15.10.466
2g1n1IGRenin3.4.23.150.466
3eon341Glutaryl-CoA dehydrogenase/0.466
3umvFADDeoxyribodipyrimidine photo-lyase4.1.99.30.466
4u0oMTALipoyl synthase 2/0.466
4yswNAIXanthine dehydrogenase/oxidase/0.466
1fmjRTLRetinol dehydratase/0.465
1kl2FONSerine hydroxymethyltransferase/0.465
1u3cFADCryptochrome-1/0.465
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
2ghlLIBMitogen-activated protein kinase 14/0.465
2oaxSNLMineralocorticoid receptor/0.465
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.465
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.465
1eioGCHGastrotropin/0.464
1h50FMNPentaerythritol tetranitrate reductase/0.464
2iviACWIsopenicillin N synthase1.21.3.10.464
2qo9ANPEphrin type-A receptor 32.7.10.10.464
3c11GDMATP-dependent molecular chaperone HSP82/0.464
3wrhCAMCamphor 5-monooxygenase1.14.15.10.464
4b1rITCTetracycline repressor protein class D/0.464
4gk3L87Ephrin type-A receptor 32.7.10.10.464
1m13HYFNuclear receptor subfamily 1 group I member 2/0.463
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.463
3h3t16HCollagen type IV alpha-3-binding protein/0.463
3nglNAPBifunctional protein FolD/0.463
3qn1A8SAbscisic acid receptor PYR1/0.463
4cdmFO1Deoxyribodipyrimidine photolyase/0.463
4j6cSTRCytochrome P450 monooxygenase/0.463
4l4cCAMCamphor 5-monooxygenase1.14.15.10.463
4l4dCAMCamphor 5-monooxygenase1.14.15.10.463
1fvpFMANon-fluorescent flavoprotein/0.462
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.462
2exlGDMEndoplasmin/0.462
2qbmCAMCamphor 5-monooxygenase1.14.15.10.462
3k3kA8SAbscisic acid receptor PYR1/0.462
3p3zP3ZPutative cytochrome P450/0.462
4jdaA9SAbscisic acid receptor PYL3/0.462
2mm3GCHGastrotropin/0.461
2rhrEMOPutative ketoacyl reductase1.3.10.461
2x9fX9FEphrin type-B receptor 42.7.10.10.461
3f03FMNPentaerythritol tetranitrate reductase/0.461
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.461
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
3otwCOAPhosphopantetheine adenylyltransferase/0.461
4ipw1G7Mycocyclosin synthase1.14.21.90.461
4l4eCAMCamphor 5-monooxygenase1.14.15.10.461
4lwaQ13Nitric oxide synthase oxygenase1.14.13.1650.461
4n6hEJ4Delta-type opioid receptor/0.461
4qa1B3NHistone deacetylase 83.5.1.980.461
1jraFADFAD-linked sulfhydryl oxidase ERV21.8.3.20.460
1k6tXN1Gag-Pol polyprotein3.4.23.160.460
1klkPMDDihydrofolate reductase1.5.1.30.460
2blaCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.460
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.460
3wrlCAMCamphor 5-monooxygenase1.14.15.10.460
3zewSTUEphrin type-B receptor 42.7.10.10.460
4aoxFADSteroid monooxygenase/0.460
1dhjMTXDihydrofolate reductase1.5.1.30.459
1iwjCAMCamphor 5-monooxygenase1.14.15.10.459
1o76CAMCamphor 5-monooxygenase1.14.15.10.459
2bkzSBCCyclin-dependent kinase 22.7.11.220.459
3ih0ANPUncharacterized sugar kinase PH14592.7.10.459
3iodA6DPantothenate synthetase6.3.2.10.459
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.459
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.459
1ao8MTXDihydrofolate reductase1.5.1.30.458
1bsvNDPGDP-L-fucose synthase/0.458
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.458
1r2jFADFkbI/0.458
1vyw292Cyclin-dependent kinase 22.7.11.220.458
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.458
2a1oCAMCamphor 5-monooxygenase1.14.15.10.458
2jedLG8Protein kinase C theta type2.7.11.130.458
2nnqT4BFatty acid-binding protein, adipocyte/0.458
2y3sTIRTamL/0.458
3gwfFADCyclohexanone monooxygenase/0.458
3lxiCAMCytochrome P450/0.458
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.458
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.458
4uymVOR14-alpha sterol demethylase Cyp51B/0.458
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.458
2itxANPEpidermal growth factor receptor2.7.10.10.457
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.457
2vww7X2Ephrin type-B receptor 42.7.10.10.457
2x0iNAIMalate dehydrogenase/0.457
3d8vUD1Bifunctional protein GlmU/0.457
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.457
3qt62P0Mevalonate diphosphate decarboxylase/0.457
3r6pA8SAbscisic acid receptor PYL10/0.457
3uftHW7Nitric oxide synthase, brain1.14.13.390.457
3v1s0LHStrictosidine synthase4.3.3.20.457
3vfa031Gag-Pol polyprotein3.4.23.160.457
4b99R4LMitogen-activated protein kinase 72.7.11.240.457
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.457
4i2q1BTGag-Pol polyprotein2.7.7.490.457
1bygSTUTyrosine-protein kinase CSK/0.456
1hdgNADGlyceraldehyde-3-phosphate dehydrogenase/0.456
1suoCPZCytochrome P450 2B41.14.14.10.456
1zky689Estrogen receptor/0.456
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.456
3a783EVVitamin D3 receptor/0.456
3cppCAMCamphor 5-monooxygenase1.14.15.10.456
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.456
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.456
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.456
3zuyTCHTransporter/0.456
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
4y9rFADNADPH--cytochrome P450 reductase/0.456
1lb9DNQGlutamate receptor 2/0.455
1nzdUPGDNA beta-glucosyltransferase/0.455
1phgMYTCamphor 5-monooxygenase1.14.15.10.455
1xddAAYIntegrin alpha-L/0.455
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.455
2vw5BC6ATP-dependent molecular chaperone HSP82/0.455
2w6zL21Biotin carboxylase6.3.4.140.455
2x9dITCTetracycline repressor protein class D/0.455
3drcMTXDihydrofolate reductase1.5.1.30.455
3l8sBFFMitogen-activated protein kinase 14/0.455
3own3OWRenin3.4.23.150.455
3r9uFADThioredoxin reductase/0.455
3tnlNADShikimate dehydrogenase (NADP(+))/0.455
4mv8ACPBiotin carboxylase6.3.4.140.455
4ug91EWNitric oxide synthase oxygenase1.14.13.1650.455
4yaoFMNNADPH--cytochrome P450 reductase/0.455
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
1i58ACPChemotaxis protein CheA2.7.13.30.454
1im2ADPATP-dependent protease ATPase subunit HslU/0.454
1k7fIAVTryptophan synthase alpha chain/0.454
2bu9HFVIsopenicillin N synthase1.21.3.10.454
2uxoTACHTH-type transcriptional regulator TtgR/0.454
3h3r14HCollagen type IV alpha-3-binding protein/0.454
3hv71AUMitogen-activated protein kinase 14/0.454
3k3jF4CMitogen-activated protein kinase 14/0.454
3zu2NAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.454
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.454
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.454
4lwbQJ8Nitric oxide synthase oxygenase1.14.13.1650.454
4qa0SHHHistone deacetylase 83.5.1.980.454
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.454
5cccDDFDihydrofolate reductase1.5.1.30.454
5cp4CAMCamphor 5-monooxygenase1.14.15.10.454
1cs4FOKAdenylate cyclase type 2/0.453
1cs4FOKAdenylate cyclase type 5/0.453
1m8jNADNicotinamide-nucleotide adenylyltransferase2.7.7.10.453
1m9tINENitric oxide synthase, inducible1.14.13.390.453
1p33MTXPteridine reductase 11.5.1.330.453
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
1tezFADDeoxyribodipyrimidine photo-lyase4.1.99.30.453
1yimCM4Estrogen receptor/0.453
2zsiGA4Gibberellin receptor GID1A30.453
2zuiCAMCamphor 5-monooxygenase1.14.15.10.453
3dhbC6LN-acyl homoserine lactonase AiiA3.1.1.810.453
4bfsZVSPantothenate kinase2.7.1.330.453
5bsfNADPyrroline-5-carboxylate reductase/0.453
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.453
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
1hfpMOTDihydrofolate reductase1.5.1.30.452
2g2fAGSTyrosine-protein kinase ABL12.7.10.20.452
2vx07X7Ephrin type-B receptor 42.7.10.10.452
2yee2ECHeat shock protein HSP 90-alpha/0.452
3d84NDPDihydrofolate reductase1.5.1.30.452
3e7iB2Nitric oxide synthase, inducible1.14.13.390.452
4a9e3PFBromodomain-containing protein 2/0.452
4c9oCAMCytochrome P450/0.452
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.452
4gncASORegucalcin3.1.1.170.452
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.452
4kne1CYDihydrofolate reductase1.5.1.30.452
4l49CAMCamphor 5-monooxygenase1.14.15.10.452
4l4aCAMCamphor 5-monooxygenase1.14.15.10.452
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.452
4xivADPChemotaxis protein CheA2.7.13.30.452
1f4fTP3Thymidylate synthase/0.451
1fmlRTLRetinol dehydratase/0.451
2acxANPG protein-coupled receptor kinase 62.7.11.160.451
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.451
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.451
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.451
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.451
3gwfNAPCyclohexanone monooxygenase/0.451
3ibqATPPyridoxal kinase/0.451
3lanKBTGag-Pol polyprotein2.7.7.490.451
3ov4EQUSteroid Delta-isomerase5.3.3.10.451
3q3cNADNAD-dependent L-serine dehydrogenase/0.451
3q44D50M1 family aminopeptidase3.4.110.451
4cp4CAMCamphor 5-monooxygenase1.14.15.10.451
4g2fC07Ephrin type-A receptor 32.7.10.10.451
4h4uNDPBiphenyl dioxygenase ferredoxin reductase subunit/0.451
4k9yK9YFocal adhesion kinase 12.7.10.20.451
4r20AERCytochrome P450 family 17 polypeptide 2/0.451
1c1bGCAGag-Pol polyprotein2.7.7.490.450
1orhSAHProtein arginine N-methyltransferase 1/0.450
1v0pPVBCell division control protein 2 homolog2.7.11.220.450
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.450
2itwITQEpidermal growth factor receptor2.7.10.10.450
2wihP48Cyclin-dependent kinase 22.7.11.220.450
2wpa889Cyclin-dependent kinase 22.7.11.220.450
2y882ERPhosphoribosyl isomerase A5.3.1.160.450
3pl8FADPyranose 2-oxidase/0.450
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.450
4ejh0QACytochrome P450 2A131.14.14.10.450
4fhf0TTSpore photoproduct lyase/0.450
4g3rCAMCamphor 5-monooxygenase1.14.15.10.450
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.450
4lhtCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.450
4lxhC1EAlpha/beta hydrolase fold/0.450
4pd5GEONucleoside permease/0.450
4ugaQ05Nitric oxide synthase oxygenase1.14.13.1650.450
5aqzSGVHeat shock 70 kDa protein 1A/0.450
1d2sDHTSex hormone-binding globulin/0.449
1dhiMTXDihydrofolate reductase1.5.1.30.449
1e8xATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.449
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.449
2oj9BMIInsulin-like growth factor 1 receptor2.7.10.10.449
2q46NAPUncharacterized protein At5g02240/0.449
2y37A54Nitric oxide synthase, inducible1.14.13.390.449
3kp4MIITranscriptional regulator TcaR/0.449
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.449
3mdvCL6Cholesterol 24-hydroxylase/0.449
3nwq2NCGag-Pol polyprotein3.4.23.160.449
3qqgX06Cyclin-dependent kinase 22.7.11.220.449
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.449
3tm5SFGUncharacterized protein/0.449
4bchT7ZCyclin-dependent kinase 92.7.11.220.449
4ejgNCTCytochrome P450 2A131.14.14.10.449
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.449
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.449
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.449
4m83ERYOleandomycin glycosyltransferase2.4.10.449
4tx9AMZPhosphoribosyl isomerase A/0.449
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.449
1ia3TQ5Dihydrofolate reductase1.5.1.30.448
1osvCHCBile acid receptor/0.448
1q51CAA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.448
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.448
2hk51BMTyrosine-protein kinase HCK2.7.10.20.448
2tpsTPSThiamine-phosphate synthase/0.448
2vcmM11Isopenicillin N synthase1.21.3.10.448
2vwcBC2ATP-dependent molecular chaperone HSP82/0.448
2zjwREFCasein kinase II subunit alpha2.7.11.10.448
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.448
3keqNADRedox-sensing transcriptional repressor Rex/0.448
3kq7KQ7Mitogen-activated protein kinase 14/0.448
3oafOAGDihydrofolate reductase1.5.1.30.448
3qrtX14Cyclin-dependent kinase 22.7.11.220.448
3sai9DRDihydrofolate reductase/0.448
4dx7DM2Multidrug efflux pump subunit AcrB/0.448
4eor4SPCyclin-dependent kinase 22.7.11.220.448
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.448
4pb25UDNucleoside permease/0.448
5d7pOCZNAD-dependent protein deacetylase sirtuin-23.5.10.448
5einNAP[LysW]-L-2-aminoadipate 6-phosphate reductase/0.448
1culFOKAdenylate cyclase type 2/0.447
1culFOKAdenylate cyclase type 5/0.447
1di8DTQCyclin-dependent kinase 22.7.11.220.447
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
1ftlDNQGlutamate receptor 2/0.447
1m9k7NINitric oxide synthase, endothelial1.14.13.390.447
1obnASVIsopenicillin N synthase1.21.3.10.447
2a1mCAMCamphor 5-monooxygenase1.14.15.10.447
2btsU32Cyclin-dependent kinase 22.7.11.220.447
2hamC33Vitamin D3 receptor/0.447
2itnANPEpidermal growth factor receptor2.7.10.10.447
2o7pNAPRiboflavin biosynthesis protein RibD/0.447
2ocfESTEstrogen receptor/0.447
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.447
2q9fC3SCholesterol 24-hydroxylase/0.447
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
2y3rTRKTamL/0.447
2y3rTIRTamL/0.447
3cnjFADCholesterol oxidase1.1.3.60.447
3junAKDPhenazine biosynthesis protein A/B/0.447
3nwxKVSGag-Pol polyprotein3.4.23.160.447
3u8hBHPPhospholipase A2, membrane associated/0.447
4c9pCAMCytochrome P450/0.447
4dp3MMVBifunctional dihydrofolate reductase-thymidylate synthase/0.447
4fgcPQ0NADPH-dependent 7-cyano-7-deazaguanine reductase1.7.1.130.447
4iah1DXAlr2278 protein/0.447
4iteTEYVitamin D3 receptor/0.447
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.447
4m2xTMQDihydrofolate reductase1.5.1.30.447
4r1fADPDNA topoisomerase 2-alpha5.99.1.30.447
4xdmGDMHeat shock cognate 90 kDa protein/0.447
5a3bAPRSIR2 family protein/0.447
5fm7ADPRuvB-like helicase/0.447
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1gwrESTEstrogen receptor/0.446
1hb1OCVIsopenicillin N synthase1.21.3.10.446
1lhoAOMSex hormone-binding globulin/0.446
1s19MC9Vitamin D3 receptor/0.446
1vyrFMNPentaerythritol tetranitrate reductase/0.446
2b1z17MEstrogen receptor/0.446
2of4979Tyrosine-protein kinase Lck2.7.10.20.446
2oji33AMitogen-activated protein kinase 12.7.11.240.446
2p5uNADUDP-glucose 4-epimerase/0.446
2po7CHDFerrochelatase, mitochondrial4.99.1.10.446
2r38G4GGag-Pol polyprotein3.4.23.160.446
2uxuNARHTH-type transcriptional regulator TtgR/0.446
2y1tDUDSPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS3.6.1.230.446
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.446
3n8nN883-dehydroquinate dehydratase4.2.1.100.446
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
3oibFDAPutative acyl-CoA dehydrogenase/0.446
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.446
3zoiM2WIsopenicillin N synthase1.21.3.10.446
4as76LXKinesin-like protein KIF11/0.446
4b7sQLECytochrome P450 monooxygenase PikC/0.446
4g1z0VPVitamin D3 receptor A/0.446
4lsl1YQGag-Pol polyprotein2.7.7.490.446
1dduCB3Thymidylate synthase/0.445
1kfbIGPTryptophan synthase alpha chain/0.445
1kquBR4Phospholipase A2, membrane associated/0.445
1me7RVPInosine-5'-monophosphate dehydrogenase/0.445
1rm5NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic1.2.1.130.445
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.445
1xl2189Gag-Pol polyprotein3.4.23.160.445
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.445
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.445
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2rlcCHDCholoylglycine hydrolase3.5.1.240.445
2vmyFFOSerine hydroxymethyltransferase/0.445
2y60M8FIsopenicillin N synthase1.21.3.10.445
2y6o1N1Ephrin type-A receptor 42.7.10.10.445
3ac2KSETyrosine-protein kinase Lck2.7.10.20.445
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.445
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.445
3mvl38PMitogen-activated protein kinase 14/0.445
3nmvPYVAbscisic acid receptor PYL2/0.445
3pejBC2Endoplasmin homolog, putative/0.445
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.445
3vrwYS5Vitamin D3 receptor/0.445
4bfxZVXPantothenate kinase2.7.1.330.445
4c02TAKActivin receptor type-12.7.11.300.445
4fmxCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.445
4g47TZFMycocyclosin synthase1.14.21.90.445
4gk4L90Ephrin type-A receptor 32.7.10.10.445
4jqlVJ6Heat shock protein HSP 90-alpha/0.445
4nieNBHNuclear receptor ROR-gamma/0.445
4nmdFDABifunctional protein PutA/0.445
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.445
1bozPRDDihydrofolate reductase1.5.1.30.444
1cbfSAHCobalt-precorrin-4 C(11)-methyltransferase2.1.1.2710.444
1cq7PY5Aspartate aminotransferase2.6.1.10.444
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.444
1kdmDHTSex hormone-binding globulin/0.444
1n3rGTPGTP cyclohydrolase 13.5.4.160.444
1oirHDYCyclin-dependent kinase 22.7.11.220.444
1oiyN41Cyclin-dependent kinase 22.7.11.220.444
1rt5UC2Gag-Pol polyprotein2.7.7.490.444
1xp9AIJEstrogen receptor/0.444
2a9y26AAdenosine kinase2.7.1.200.444
2cduFADNADH oxidase/0.444
2ejvNADL-threonine 3-dehydrogenase/0.444
2ft9CHDFatty acid-binding protein 2, liver/0.444
2ftoCB3Thymidylate synthase/0.444
2obxINI6,7-dimethyl-8-ribityllumazine synthase 22.5.1.780.444
2ouzC3DEstrogen receptor/0.444
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.444
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.444
2xfsJ01Uncharacterized protein/0.444
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.444
3flwFLWMitogen-activated protein kinase 14/0.444
3gggNADPrephenate dehydrogenase/0.444
3hk1B64Fatty acid-binding protein, adipocyte/0.444
3idsNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.444
3lfeZ84Mitogen-activated protein kinase 14/0.444
3r73X87Cyclin-dependent kinase 22.7.11.220.444
3sh25DRDihydrofolate reductase1.5.1.30.444
3sls77DDual specificity mitogen-activated protein kinase kinase 12.7.12.20.444
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.444
4l8u9AZSerum albumin/0.444
4l9q9TPSerum albumin/0.444
4o2bLOCTubulin beta-2B chain/0.444
5c8yACPTubulin tyrosine ligase/0.444
5dhhDGWNociceptin receptor/0.444
1aquESTEstrogen sulfotransferase, testis isoform2.8.2.40.443
1dnaCB3Thymidylate synthase/0.443
1g9cBABBotulinum neurotoxin type B3.4.24.690.443
1gebCAMCamphor 5-monooxygenase1.14.15.10.443
1m9m6NINitric oxide synthase, endothelial1.14.13.390.443
1rgsCMPcAMP-dependent protein kinase type I-alpha regulatory subunit/0.443
1tduDURThymidylate synthase/0.443
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.443
2oc9IMHPurine nucleoside phosphorylase2.4.2.10.443
2om9AJAPeroxisome proliferator-activated receptor gamma/0.443
2qfvNAPIsocitrate dehydrogenase [NADP], mitochondrial1.1.1.420.443
2r2nKYNKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.443
2w3wVG9Dihydrofolate reductase/0.443
2w6pOA4Biotin carboxylase6.3.4.140.443
2xszATPRuvB-like 23.6.4.120.443
2y4gTIRTamL/0.443
3c3dFO12-phospho-L-lactate transferase/0.443
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.443
3cktYDPGag-Pol polyprotein3.4.23.160.443
3csdEMOPutative ketoacyl reductase1.3.10.443
3h03UBPGlutamate receptor 2/0.443
3h3sH15Collagen type IV alpha-3-binding protein/0.443
3mvqNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.443
3pd3A3TThreonine--tRNA ligase6.1.1.30.443
3qfxCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
3r7eX88Cyclin-dependent kinase 22.7.11.220.443
3srwQ27Dihydrofolate reductase1.5.1.30.443
3t3q9PLCytochrome P450 2A61.14.130.443
3v1yNADGlyceraldehyde-3-phosphate dehydrogenase 1, cytosolic1.2.1.120.443
3w0hW12Vitamin D3 receptor/0.443
4du82P0Mevalonate diphosphate decarboxylase/0.443
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.443
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.443
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.443
4nm9FADBifunctional protein PutA/0.443
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1ir3ANPInsulin receptor2.7.10.10.442
1lhwESMSex hormone-binding globulin/0.442
1o9bNAIQuinate/shikimate dehydrogenase/0.442
1w87NAPFerredoxin--NADP reductase1.18.1.20.442
1y0s331Peroxisome proliferator-activated receptor delta/0.442
2balPQAMitogen-activated protein kinase 14/0.442
2blcCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
2ejzSAHDiphthine synthase/0.442
2eq7NADDihydrolipoyl dehydrogenase/0.442
2gs7ANPEpidermal growth factor receptor2.7.10.10.442
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.442
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
2rehFADNitroalkane oxidase1.7.3.10.442
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.442
3i81EBIInsulin-like growth factor 1 receptor2.7.10.10.442
3iqzH4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.442
3jv7NADSecondary alcohol dehydrogenase/0.442
3nnxEDDMitogen-activated protein kinase 14/0.442
3t1kANPHeat shock protein HSP 90-alpha/0.442
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4bcqTJFCyclin-dependent kinase 22.7.11.220.442
4e5yNDPGDP-L-fucose synthase1.1.1.2710.442
4ead0NPThymidine phosphorylase2.4.2.40.442
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4grb0XGCasein kinase II subunit alpha2.7.11.10.442
4h9506UDihydrofolate reductase1.5.1.30.442
4hz519YDNA topoisomerase 4 subunit B/0.442
4iyg1HUStrictosidine synthase4.3.3.20.442
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.442
4jia1K3Tyrosine-protein kinase JAK2/0.442
1al8DHPPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.441
1dbvNADGlyceraldehyde-3-phosphate dehydrogenase/0.441
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1omoNADAlanine dehydrogenase/0.441
1rx7FOLDihydrofolate reductase1.5.1.30.441
1sr7MOFProgesterone receptor/0.441
1vj3TABDihydrofolate reductase1.5.1.30.441
2bxmIMNSerum albumin/0.441
2fr0NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/0.441
2itvANPEpidermal growth factor receptor2.7.10.10.441
2nr4FMNConserved protein/0.441
2vwz7X6Ephrin type-B receptor 42.7.10.10.441
2xvdAS6Ephrin type-B receptor 42.7.10.10.441
2y6fM9FIsopenicillin N synthase1.21.3.10.441
2zm4KSMTyrosine-protein kinase Lck2.7.10.20.441
2znpK55Peroxisome proliferator-activated receptor delta/0.441
3b9lAZZSerum albumin/0.441
3dmhSAMProbable ribosomal RNA small subunit methyltransferase/0.441
3eem53VUncharacterized protein/0.441
3etgNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.441
3flzFLZMitogen-activated protein kinase 14/0.441
3ixp834Ecdysone receptor/0.441
3mdmFJZCholesterol 24-hydroxylase/0.441
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.441
3p5kP5KMitogen-activated protein kinase 14/0.441
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.441
3vjcZGASqualene synthase2.5.1.210.441
4bcoT6QCyclin-dependent kinase 22.7.11.220.441
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.441
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
4dpuAGSMevalonate diphosphate decarboxylase/0.441
4dsbA8SAbscisic acid receptor PYL3/0.441
4f700STCyclin-dependent kinase 82.7.11.220.441
4g8zTOPDihydrofolate reductase1.5.1.30.441
4i1nFOLDihydrofolate reductase1.5.1.30.441
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
4nmcFADBifunctional protein PutA/0.441
4qq3XMPInosine-5'-monophosphate dehydrogenase/0.441
5dc5B3NHistone deacetylase 83.5.1.980.441
1crbRTLRetinol-binding protein 1/0.440
1hk4T44Serum albumin/0.440
1l2jETCEstrogen receptor beta/0.440
1owoFADDeoxyribodipyrimidine photo-lyase4.1.99.30.440
1pq944BOxysterols receptor LXR-beta/0.440
1q66KMBQueuine tRNA-ribosyltransferase2.4.2.290.440
1vzdCB3Thymidylate synthase/0.440
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
1yjqNAP2-dehydropantoate 2-reductase1.1.1.1690.440
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.440
2bjfDXCCholoylglycine hydrolase3.5.1.240.440
2cppCAMCamphor 5-monooxygenase1.14.15.10.440
2fj1CTCTetracycline repressor protein class D/0.440
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.440
2iorADPChaperone protein HtpG/0.440
2j5sKTAAlr4455 protein/0.440
2jcvNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.440
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.440
2z7lS91Mitogen-activated protein kinase 12.7.11.240.440
2znq401Peroxisome proliferator-activated receptor delta/0.440
3aidARQGag-Pol polyprotein3.4.23.160.440
3akzGSUGlutamate--tRNA ligase 2/0.440
3gncQQQGlutaryl-CoA dehydrogenase/0.440
3lfcZ86Mitogen-activated protein kinase 14/0.440
3mqe416Prostaglandin G/H synthase 21.14.99.10.440
3oquA8SAbscisic acid receptor PYL9/0.440
3qp0NI8Gag-Pol polyprotein3.4.23.160.440
3r1sX73Cyclin-dependent kinase 22.7.11.220.440
3tbaADPRibonucleoside-diphosphate reductase large chain 11.17.4.10.440
4cfnJYMCyclin-dependent kinase 22.7.11.220.440
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.440
4jvlESTEstrogen sulfotransferase2.8.2.40.440
4nmbFADBifunctional protein PutA/0.440
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.440
4yqfGDPSeptin-9/0.440
3uzcT4EAdenosine receptor A2a/0.440