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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4j0r1H2Bromodomain-containing protein 4

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4j0r1H2Bromodomain-containing protein 4/1.000
4j0s1H3Bromodomain-containing protein 4/0.805
4c66H4CBromodomain-containing protein 4/0.658
4mr41K0Bromodomain-containing protein 4/0.647
4aknS5BBromodomain-containing protein 2/0.636
4a9oA9OBromodomain-containing protein 2/0.631
4o74R78Bromodomain-containing protein 4/0.619
4hxs1A3Bromodomain-containing protein 4/0.616
4meq25OBromodomain-containing protein 4/0.613
4hxo1A6Bromodomain-containing protein 4/0.609
4lr61XABromodomain-containing protein 4/0.608
4ogiR78Bromodomain-containing protein 4/0.607
4bw39BMBromodomain-containing protein 4/0.606
4a9nA9NBromodomain-containing protein 2/0.604
4lrg1XBBromodomain-containing protein 4/0.601
4bjx73BBromodomain-containing protein 4/0.599
2yelWSHBromodomain-containing protein 4/0.598
4bw2UTHBromodomain-containing protein 4/0.596
4men25KBromodomain-containing protein 4/0.596
4uyg73BBromodomain-containing protein 2/0.594
4hxr1A4Bromodomain-containing protein 4/0.593
3zyu1GHBromodomain-containing protein 4/0.587
4nqmY1ZBromodomain-containing protein 4/0.586
4bw1S5BBromodomain-containing protein 4/0.583
4hxn1A7Bromodomain-containing protein 4/0.583
4mep24YBromodomain-containing protein 4/0.581
4alhA9PBromodomain-containing protein 2/0.580
4flpJQ1Bromodomain testis-specific protein/0.580
4hby13FBromodomain-containing protein 4/0.577
4o71CPBBromodomain-containing protein 4/0.569
4alg1GHBromodomain-containing protein 2/0.568
3aqaBYHBromodomain-containing protein 2/0.567
4a9lP9LBromodomain-containing protein 4/0.567
4c67L5SBromodomain-containing protein 4/0.566
4lyw21QBromodomain-containing protein 4/0.563
2yemWSHBromodomain-containing protein 4/0.561
4j3i1K0Bromodomain-containing protein 4/0.556
4qzsJQ1Bromodomain-containing protein 4/0.554
2ydwWSHBromodomain-containing protein 2/0.552
4f3i0S6Bromodomain-containing protein 4/0.544
5bt52LOBromodomain-containing protein 2/0.540
4bw49B6Bromodomain-containing protein 4/0.538
4gpj0Q1Bromodomain-containing protein 4/0.538
4mr61K0Bromodomain-containing protein 2/0.537
3ia4MTXDihydrofolate reductase/0.529
4cfl8DQBromodomain-containing protein 4/0.527
4j1p1K0Bromodomain-containing protein 2/0.526
2yekEAMBromodomain-containing protein 2/0.524
5bt42LOBromodomain-containing protein 4/0.517
4py6R78Bromodomain protein, putative/0.513
4cfkLY2Bromodomain-containing protein 4/0.511
4meo25VBromodomain-containing protein 4/0.511
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.504
4o78SAVBromodomain-containing protein 4/0.498
1ykdCMPAdenylate cyclase/0.495
3nga3NGCasein kinase II subunit alpha2.7.11.10.492
4nr52LLCREB-binding protein/0.490
2xvv9DNSerum albumin/0.488
3srqQ19Dihydrofolate reductase1.5.1.30.488
4fhi0S4Vitamin D3 receptor A/0.488
4hxm1A8Bromodomain-containing protein 4/0.488
4hnbFMNLOV protein/0.487
1m78NDPDihydrofolate reductase1.5.1.30.486
3ibqATPPyridoxal kinase/0.486
1kqwRTLCellular retinol-binding protein type II/0.485
2zzaFOLDihydrofolate reductase/0.485
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.485
1pl8NADSorbitol dehydrogenase1.1.1.140.484
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.484
2x6dX6DAurora kinase A2.7.11.10.482
4cdmFO1Deoxyribodipyrimidine photolyase/0.482
3sn6P0GBeta-2 adrenergic receptor/0.482
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.481
4e1z0MXNon-receptor tyrosine-protein kinase TYK22.7.10.20.481
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.480
4rujVDXVitamin D3 receptor A/0.479
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.478
2w3vTOPDihydrofolate reductase/0.478
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.478
3vt9YI4Vitamin D3 receptor/0.477
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.476
3b9lAZZSerum albumin/0.476
3wv7ADPHmd co-occurring protein HcgE/0.476
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.476
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.475
4y8wSTRSteroid 21-hydroxylase/0.475
2xvw9NRSerum albumin/0.474
4ia3BIVVitamin D3 receptor A/0.474
4ruoBIVVitamin D3 receptor A/0.474
2bxqIMNSerum albumin/0.473
3h4vNAPPteridine reductase 11.5.1.330.473
4c02TAKActivin receptor type-12.7.11.300.473
1rt5UC2Gag-Pol polyprotein2.7.7.490.472
1y4lSVRBasic phospholipase A2 homolog 2/0.472
3eej53RUncharacterized protein/0.472
3svgODRBromodomain-containing protein 4/0.472
3vt7VDXVitamin D3 receptor/0.472
4cd2FOLDihydrofolate reductase1.5.1.30.472
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.472
1vj3TABDihydrofolate reductase1.5.1.30.470
2acwUPGGlycosyltransferase/0.470
2yy7NADL-threonine dehydrogenase/0.470
3sa16DRDihydrofolate reductase/0.470
4azwATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.470
1db1VDXVitamin D3 receptor/0.469
2a4zBYMPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.469
2oaxSNLMineralocorticoid receptor/0.469
2ovhAS0Progesterone receptor/0.469
2zbaZBATrichothecene 3-O-acetyltransferase/0.469
3l8p0CEAngiopoietin-1 receptor2.7.10.10.469
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.469
4q0a4OAVitamin D3 receptor A/0.469
2pywADPMethylthioribose kinase2.7.1.1000.468
3p7nFMNLight-activated DNA-binding protein EL222/0.468
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.468
4r1lADPPhenylacetate-coenzyme A ligase/0.468
5dr2ATPAurora kinase A2.7.11.10.468
2a3iC0RMineralocorticoid receptor/0.467
2abi1CAMineralocorticoid receptor/0.467
2puiADPMethylthioribose kinase2.7.1.1000.467
3i0rRT3Gag-Pol polyprotein2.7.7.490.467
4tuvCPZCytochrome P450 1191.140.467
2pulACPMethylthioribose kinase2.7.1.1000.466
2q5oPPYIndole-3-pyruvate decarboxylase4.1.1.740.466
3ddw055Glycogen phosphorylase, liver form2.4.1.10.466
3oquA8SAbscisic acid receptor PYL9/0.466
3pd3A3TThreonine--tRNA ligase6.1.1.30.466
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.466
4dgo0JWCasein kinase II subunit alpha2.7.11.10.466
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.466
5eccNAPDehydrofolate reductase type I/0.466
2rhrEMOPutative ketoacyl reductase1.3.10.465
3tk3CPZCytochrome P450 2B41.14.14.10.465
4do30LAFatty-acid amide hydrolase 13.5.1.990.465
4ia7BIVVitamin D3 receptor A/0.465
4jajXU1Aurora kinase A2.7.11.10.465
5dn3ATPAurora kinase A2.7.11.10.465
6cp4CAMCamphor 5-monooxygenase1.14.15.10.465
1t88CAMCamphor 5-monooxygenase1.14.15.10.464
3m8p65BGag-Pol polyprotein2.7.7.490.464
3rmf20ZCyclin-dependent kinase 22.7.11.220.464
4eerFMNPhototropin-22.7.11.10.464
4nyw2O3CREB-binding protein/0.464
4xe606UDihydrofolate reductase1.5.1.30.464
3cseN22Uncharacterized protein/0.463
3njoP2MAbscisic acid receptor PYR1/0.463
3srrQ20Dihydrofolate reductase1.5.1.30.463
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.463
3vt8YI3Vitamin D3 receptor/0.463
4aotGW8Serine/threonine-protein kinase 102.7.11.10.463
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.463
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.463
5dfcEAMBromodomain-containing protein 2/0.463
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.462
2q5oTPWIndole-3-pyruvate decarboxylase4.1.1.740.462
3freTOPDihydrofolate reductase1.5.1.30.462
3nr4PYVAbscisic acid receptor PYL2/0.462
3sw719KCyclin-dependent kinase 22.7.11.220.462
4ir5IR5Bromodomain adjacent to zinc finger domain protein 2B/0.462
4rupH97Vitamin D3 receptor A/0.462
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.462
1aoeGW3Dihydrofolate reductase1.5.1.30.461
1dz6CAMCamphor 5-monooxygenase1.14.15.10.461
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.461
3upf0BUPolyprotein/0.461
4g1z0VPVitamin D3 receptor A/0.461
1cm8ANPMitogen-activated protein kinase 12/0.460
1kzjCB3Thymidylate synthase/0.460
1um0FMNChorismate synthase/0.460
2o4rVD5Vitamin D3 receptor/0.460
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.460
3vt5YI2Vitamin D3 receptor/0.460
4ia1BIVVitamin D3 receptor A/0.460
4nr82LLBromodomain-containing protein 4/0.460
1dhiMTXDihydrofolate reductase1.5.1.30.459
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.459
1ybgTAVUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.459
2blcCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.459
2jkqVG8Focal adhesion kinase 12.7.10.20.459
2x7jTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.459
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.459
3w0aDS5Vitamin D3 receptor/0.459
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.459
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.459
4gub0Y4Casein kinase II subunit alpha2.7.11.10.459
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.459
1s3sADPTransitional endoplasmic reticulum ATPase3.6.4.60.458
1yrdCAMCamphor 5-monooxygenase1.14.15.10.458
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.458
3d0bSNXHeat shock protein HSP 90-alpha/0.458
3kpzZNEVitamin D3 receptor/0.458
3pe6ZYHMonoglyceride lipase/0.458
4hvh19RTyrosine-protein kinase JAK32.7.10.20.458
4jbqVX6Aurora kinase A2.7.11.10.458
5ai5BSUBifunctional epoxide hydrolase 23.1.3.760.458
1dkfBMSRetinoic acid receptor alpha/0.457
1j7kATPHolliday junction ATP-dependent DNA helicase RuvB/0.457
1rx1NAPDihydrofolate reductase1.5.1.30.457
2b7aIZATyrosine-protein kinase JAK2/0.457
2bxmIMNSerum albumin/0.457
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.457
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.457
3frdDHFDihydrofolate reductase1.5.1.30.457
3fwjCAMCamphor 5-monooxygenase1.14.15.10.457
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.457
4fgg0U5Dihydrofolate reductase1.5.1.30.457
4ia2BIVVitamin D3 receptor A/0.457
4prxADPDNA gyrase subunit B/0.457
1pn3TYDdTDP-epi-vancosaminyltransferase2.4.1.3110.456
2hcdBIVVitamin D3 receptor A/0.456
2ix5FADAcyl-coenzyme A oxidase 4, peroxisomal1.3.3.60.456
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.456
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.456
2wotZZGTGF-beta receptor type-12.7.11.300.456
3c6uM22Gag-Pol polyprotein2.7.7.490.456
3cyz9ODPheromone-binding protein ASP1/0.456
3sruQ26Dihydrofolate reductase1.5.1.30.456
3w5tLHPVitamin D3 receptor/0.456
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
4h9814QUncharacterized protein/0.456
4k771Q4Tyrosine-protein kinase JAK1/0.456
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.456
1opbRETRetinol-binding protein 2/0.455
1rjkVDZVitamin D3 receptor/0.455
1rx8NAPDihydrofolate reductase1.5.1.30.455
2i40BLZCyclin-dependent kinase 22.7.11.220.455
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.455
2pg0FADAcyl-CoA dehydrogenase/0.455
3anmSYD1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.455
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.455
3d84NDPDihydrofolate reductase1.5.1.30.455
3fwfCAMCamphor 5-monooxygenase1.14.15.10.455
3jwcEKBDihydrofolate reductase/0.455
3wrlCAMCamphor 5-monooxygenase1.14.15.10.455
4fgh0U6Dihydrofolate reductase1.5.1.30.455
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
4l8u9AZSerum albumin/0.455
4m11MXMProstaglandin G/H synthase 21.14.99.10.455
4nra2LWBromodomain adjacent to zinc finger domain protein 2B/0.455
1nq14HYThyroid hormone receptor beta/0.454
2fziDH3Dihydrofolate reductase1.5.1.30.454
3d78NBBPheromone-binding protein ASP1/0.454
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.454
3uli1N3Cyclin-dependent kinase 22.7.11.220.454
4fkpLS5Cyclin-dependent kinase 22.7.11.220.454
4hvi19STyrosine-protein kinase JAK32.7.10.20.454
4l2yXXKPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.454
4yswFADXanthine dehydrogenase/oxidase/0.454
5cvhADPCasein kinase II subunit alpha2.7.11.10.454
1cd2FOLDihydrofolate reductase1.5.1.30.453
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.453
1uy7PU4Heat shock protein HSP 90-alpha/0.453
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.453
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
2dwbANPAurora kinase A2.7.11.10.453
2hamC33Vitamin D3 receptor/0.453
2hc4VDXVitamin D3 receptor A/0.453
2hw2RFPRifampin ADP-ribosyl transferase/0.453
2q5qTPWIndole-3-pyruvate decarboxylase4.1.1.740.453
2uxoTACHTH-type transcriptional regulator TtgR/0.453
2wgjVGHHepatocyte growth factor receptor2.7.10.10.453
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.453
2xneASHAurora kinase A2.7.11.10.453
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.453
3bfa9ODOdorant binding protein ASP1/0.453
3cgcCOACoenzyme A disulfide reductase/0.453
3eek53SUncharacterized protein/0.453
3r5zF42Uncharacterized protein/0.453
3sa27DRDihydrofolate reductase/0.453
4aoi4K0Hepatocyte growth factor receptor2.7.10.10.453
4dymIYZActivin receptor type-12.7.11.300.453
4pd6URINucleoside permease/0.453
3emlZMAAdenosine receptor A2a/0.453
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.452
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.452
1rfuADPPyridoxal kinase2.7.1.350.452
1txiTX5Vitamin D3 receptor/0.452
2hasC3OVitamin D3 receptor/0.452
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.452
2vnhFADNADPH:ferredoxin reductase/0.452
2w6mOA1Biotin carboxylase6.3.4.140.452
2w6oOA3Biotin carboxylase6.3.4.140.452
2wouZZFTGF-beta receptor type-12.7.11.300.452
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.452
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.452
3ih0ANPUncharacterized sugar kinase PH14592.7.10.452
3ormAGSSerine/threonine protein kinase/0.452
3vs3VSETyrosine-protein kinase HCK2.7.10.20.452
4em9TCEPeroxisome proliferator-activated receptor gamma/0.452
4f650S9Fibroblast growth factor receptor 1/0.452
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.452
1likADNAdenosine kinase2.7.1.200.451
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.451
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.451
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.451
3m7rVDXVitamin D3 receptor/0.451
3nwq2NCGag-Pol polyprotein3.4.23.160.451
3vrvYSDVitamin D3 receptor/0.451
3vrwYS5Vitamin D3 receptor/0.451
3w5rLOAVitamin D3 receptor/0.451
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.451
4brxKGWFocal adhesion kinase 12.7.10.20.451
4jqeANPCasein kinase II subunit alpha2.7.11.10.451
4kl9NDPDihydrofolate reductase1.5.1.30.451
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
4ubvCOASteroid 3-ketoacyl-CoA thiolase/0.451
4zp1TPPPyruvate decarboxylase4.1.1.10.451
5aluHD2Bifunctional epoxide hydrolase 23.1.3.760.451
5dr6SKEAurora kinase A2.7.11.10.451
1draMTXDihydrofolate reductase1.5.1.30.450
1gadNADGlyceraldehyde-3-phosphate dehydrogenase A/0.450
1h1r6CPCyclin-dependent kinase 22.7.11.220.450
1itzTPPTransketolase, chloroplastic2.2.1.10.450
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.450
1rkhVD2Vitamin D3 receptor/0.450
1s19MC9Vitamin D3 receptor/0.450
2aaxPDNMineralocorticoid receptor/0.450
2excJNKMitogen-activated protein kinase 102.7.11.240.450
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.450
2izsBRQCasein kinase I isoform gamma-32.7.11.10.450
2v5aLZLBiotin carboxylase6.3.4.140.450
2zaxCAMCamphor 5-monooxygenase1.14.15.10.450
3cgbCOACoenzyme A disulfide reductase/0.450
3inxJZCHeat shock protein HSP 90-alpha/0.450
3oibFDAPutative acyl-CoA dehydrogenase/0.450
3owj1ELCasein kinase II subunit alpha2.7.11.10.450
3qlxQLRUncharacterized protein/0.450
3u9eCOALmo1369 protein/0.450
3vruYS3Vitamin D3 receptor/0.450
3w0yDS4Vitamin D3 receptor/0.450
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.450
4o0sADNAurora kinase A2.7.11.10.450
4o1pANPRibonuclease L/0.450
5k8bPDG8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase/0.450
1fbyREARetinoic acid receptor RXR-alpha/0.449
1qknRALEstrogen receptor beta/0.449
2bgiFADNADPH:ferredoxin reductase/0.449
2hb7O1CVitamin D3 receptor/0.449
2hckQUETyrosine-protein kinase HCK2.7.10.20.449
2itnANPEpidermal growth factor receptor2.7.10.10.449
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.449
2zjwREFCasein kinase II subunit alpha2.7.11.10.449
3a1nNADNDP-sugar epimerase/0.449
3a783EVVitamin D3 receptor/0.449
3dd125DGlycogen phosphorylase, liver form2.4.1.10.449
3fql79ZGenome polyprotein2.7.7.480.449
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.449
3lakKR1Gag-Pol polyprotein2.7.7.490.449
3pe2E1BCasein kinase II subunit alpha2.7.11.10.449
3qly55VUncharacterized protein/0.449
3w0jT08Vitamin D3 receptor/0.449
4c58824Cyclin-G-associated kinase2.7.11.10.449
4ez8DHFThymidylate synthase2.1.1.450.449
4g1y0VOVitamin D3 receptor A/0.449
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.449
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.449
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.449
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.449
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4nqnY1ZBromodomain-containing protein 9/0.449
1jpaANPEphrin type-B receptor 22.7.10.10.448
1m79MQ1Dihydrofolate reductase1.5.1.30.448
1t85CAMCamphor 5-monooxygenase1.14.15.10.448
1udaUFGUDP-glucose 4-epimerase5.1.3.20.448
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.448
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.448
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.448
2jkoBIJFocal adhesion kinase 12.7.10.20.448
2pziAXXSerine/threonine-protein kinase PknG2.7.11.10.448
2w9gTOPDihydrofolate reductase1.5.1.30.448
2wufKEM4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.448
3cgdCOACoenzyme A disulfide reductase/0.448
3lxpIZANon-receptor tyrosine-protein kinase TYK22.7.10.20.448
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.448
3zuxTCHTransporter/0.448
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4deeADPAurora kinase A2.7.11.10.448
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.20.448
4ejh0QACytochrome P450 2A131.14.14.10.448
4fhh0U3Vitamin D3 receptor A/0.448
4hjoAQ4Epidermal growth factor receptor2.7.10.10.448
4iteTEYVitamin D3 receptor/0.448
4ivd15TTyrosine-protein kinase JAK1/0.448
4jq8KJ8Epidermal growth factor receptor2.7.10.10.448
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.448
1eh4IC1Casein kinase I homolog 12.7.11.10.447
1fm7DFVChalcone--flavonone isomerase 15.5.1.60.447
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.447
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.447
2cchATPCyclin-dependent kinase 22.7.11.220.447
2ev9NAPShikimate dehydrogenase (NADP(+))/0.447
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.447
2pvnP63Casein kinase II subunit alpha2.7.11.10.447
2yisI46Mitogen-activated protein kinase 14/0.447
2zfaFMNLactate oxidase/0.447
2znq401Peroxisome proliferator-activated receptor delta/0.447
3at4CCKCasein kinase II subunit alpha2.7.11.10.447
3fyvXCFDihydrofolate reductase1.5.1.30.447
3gxlQIGTGF-beta receptor type-12.7.11.300.447
3koo24DBifunctional epoxide hydrolase 23.3.2.100.447
3lfcZ86Mitogen-activated protein kinase 14/0.447
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.447
3rr3FLRProstaglandin G/H synthase 21.14.99.10.447
3s1dZIRCytokinin dehydrogenase 11.5.99.120.447
3t3q9PLCytochrome P450 2A61.14.130.447
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.447
4c9pCAMCytochrome P450/0.447
4ele31IDihydrofolate reductase/0.447
4j4vSVRNucleocapsid protein/0.447
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.447
4r38RBFBlue-light-activated histidine kinase 22.7.13.30.447
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
4x5fFOLDihydrofolate reductase1.5.1.30.447
1fpqSAMIsoliquiritigenin 2'-O-methyltransferase/0.446
1i59ADPChemotaxis protein CheA2.7.13.30.446
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.446
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.446
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.446
2hb8MVDVitamin D3 receptor/0.446
2w9hTOPDihydrofolate reductase1.5.1.30.446
2zb45OPProstaglandin reductase 21.3.1.480.446
3fhxPLPPyridoxal kinase2.7.1.350.446
3hcrCHDFerrochelatase, mitochondrial4.99.1.10.446
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.446
3idsNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.446
3ijdC2FMethylenetetrahydrofolate reductase/0.446
3inwJZBHeat shock protein HSP 90-alpha/0.446
3poz03PEpidermal growth factor receptor2.7.10.10.446
3pqbVGPPutative oxidoreductase/0.446
3srwQ27Dihydrofolate reductase1.5.1.30.446
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.446
3vthAPCCarbamoyltransferase/0.446
4a2bAGSCell division protein FtsA/0.446
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.446
4bmoFMNProtein NrdI/0.446
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.446
4gurFADLysine-specific histone demethylase 1B10.446
4jr7GNPCasein kinase II subunit alpha2.7.11.10.446
4kbk1QGCasein kinase I isoform delta2.7.11.10.446
4o0wADNAurora kinase A2.7.11.10.446
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.446
4r3aRBFBlue-light-activated histidine kinase 22.7.13.30.446
4wkqIREEpidermal growth factor receptor2.7.10.10.446
4wloNAIMalate dehydrogenase, mitochondrial1.1.1.370.446
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.446
5im3DTPRibonucleoside-diphosphate reductase/0.446
5k2aZMAAdenosine receptor A2a/0.446
1aj22PHDihydropteroate synthase/0.445
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
1fmlRTLRetinol dehydratase/0.445
1jm6ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.445
1l4mNCNNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.445
1phhFADp-hydroxybenzoate hydroxylase/0.445
1ya3STRMineralocorticoid receptor/0.445
2ag1TPPBenzaldehyde lyase/0.445
2blaCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
2bunFADAppA protein/0.445
2vbpVB1Isopenicillin N synthase1.21.3.10.445
2yn8STUEphrin type-B receptor 42.7.10.10.445
3clbTMQBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
3efwAK8Aurora kinase A2.7.11.10.445
3kb1ADPIron-sulfur cluster carrier protein/0.445
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.445
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.445
3sh25DRDihydrofolate reductase1.5.1.30.445
3v3vMYUMitogen-activated protein kinase 82.7.11.240.445
4an4DUDPutative glycosyl transferase/0.445
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.445
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.445
4gk3L87Ephrin type-A receptor 32.7.10.10.445
4ixgIXGDihydrofolate reductase1.5.1.30.445
4kba1QMCasein kinase I isoform delta2.7.11.10.445
4nr42LKCREB-binding protein/0.445
4qzuRTLRetinol-binding protein 2/0.445
1m7aMQUDihydrofolate reductase1.5.1.30.444
1rk3VDXVitamin D3 receptor/0.444
1uy8PU5Heat shock protein HSP 90-alpha/0.444
1uyuCAMCamphor 5-monooxygenase1.14.15.10.444
1y4sADPChaperone protein HtpG/0.444
2aa5STRMineralocorticoid receptor/0.444
2amb17HAndrogen receptor/0.444
2c27ACOMycothiol acetyltransferase2.3.1.1890.444
2f2cAP9Cyclin-dependent kinase 62.7.11.220.444
2jf9OHTEstrogen receptor/0.444
2nxeSAMRibosomal protein L11 methyltransferase2.1.10.444
2o0uC0MMitogen-activated protein kinase 102.7.11.240.444
2obyNAPQuinone oxidoreductase PIG310.444
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.444
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
2vgpAD6Aurora kinase B-A2.7.11.10.444
2vssACOHydroxycinnamoyl-CoA hydratase-lyase4.1.2.410.444
2wtjWTJSerine/threonine-protein kinase Chk22.7.11.10.444
2xlsFADPutative flavin-containing monooxygenase/0.444
2z6dFMNPhototropin-22.7.11.10.444
3a6qFMNFMN-binding protein/0.444
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.444
3bqdDAYGlucocorticoid receptor/0.444
3drpR8EGag-Pol polyprotein2.7.7.490.444
3fi3JK2Mitogen-activated protein kinase 102.7.11.240.444
3id8MRKGlucokinase2.7.1.20.444
3lqfNADGalactitol dehydrogenase/0.444
3oom507Activin receptor type-12.7.11.300.444
3orlAGSSerine/threonine protein kinase/0.444
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.444
3slkNDPPolyketide synthase extender module 2/0.444
3tjsD0RCytochrome P450 3A4/0.444
3ttjJBIMitogen-activated protein kinase 102.7.11.240.444
3tw6ADPPyruvate carboxylase/0.444
3v1s0LHStrictosidine synthase4.3.3.20.444
3wrjCAMCamphor 5-monooxygenase1.14.15.10.444
3zep1NXTyrosine-protein kinase JAK32.7.10.20.444
4cavMYAGlycylpeptide N-tetradecanoyltransferase2.3.1.970.444
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.444
4dpuAGSMevalonate diphosphate decarboxylase/0.444
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.444
4g8bHL6Alpha/beta hydrolase fold protein/0.444
4hj4FMNLOV protein/0.444
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.444
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
4rrhA3SProbable threonine--tRNA ligase 26.1.1.30.444
4xj43ATCyclic GMP-AMP synthase/0.444
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.444
5drdATPAurora kinase A2.7.11.10.444
5kp2COA3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2/0.444
4z34ON7Lysophosphatidic acid receptor 1/0.444
1d3gBREDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.443
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.443
1fp2HMOIsoflavone-7-O-methyltransferase 82.1.1.1500.443
1iidNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.443
1m13HYFNuclear receptor subfamily 1 group I member 2/0.443
1r2jFADFkbI/0.443
1rkgVD1Vitamin D3 receptor/0.443
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.443
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.443
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.443
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.443
1wsvTHHAminomethyltransferase, mitochondrial/0.443
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
2blbCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.443
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
2drcMTXDihydrofolate reductase1.5.1.30.443
2eglSAHDiphthine synthase/0.443
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.443
2x7gPVBSRSF protein kinase 22.7.11.10.443
3cgeCOACoenzyme A disulfide reductase/0.443
3dds26BGlycogen phosphorylase, liver form2.4.1.10.443
3jw5TOPDihydrofolate reductase/0.443
3mb601ICasein kinase II subunit alpha2.7.11.10.443
3mec65BGag-Pol polyprotein2.7.7.490.443
3mnrSD1Heat shock protein HSP 90-alpha/0.443
3ns2PYVAbscisic acid receptor PYL2/0.443
3pxkPXKFocal adhesion kinase 12.7.10.20.443
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.443
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.443
3qlrQLRDihydrofolate reductase1.5.1.30.443
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.443
3up3XCAaceDAF-12/0.443
3wmxNADNAD dependent epimerase/dehydratase/0.443
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.443
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4cegADPAurora kinase A2.7.11.10.443
4fhj0TZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.443
4hgt15GCasein kinase I isoform delta2.7.11.10.443
4ixc1JDGlucokinase2.7.1.20.443
4l4cCAMCamphor 5-monooxygenase1.14.15.10.443
4ly91YYGlucokinase regulatory protein/0.443
4mleVO1Glucokinase2.7.1.20.443
4nh82LCHeat shock protein HSP 90-alpha/0.443
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.443
1bwsNDPGDP-L-fucose synthase/0.442
1drbMTXDihydrofolate reductase1.5.1.30.442
1ia1NDPDihydrofolate reductase1.5.1.30.442
1uyhPU0Heat shock protein HSP 90-alpha/0.442
1yw2PGJMitogen-activated protein kinase 14/0.442
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.442
2h96893Mitogen-activated protein kinase 82.7.11.240.442
2harOCCVitamin D3 receptor/0.442
2pupADPMethylthioribose kinase2.7.1.1000.442
2v1aFMNNPH1-1/0.442
2vcmM11Isopenicillin N synthase1.21.3.10.442
2wghDTPRibonucleoside-diphosphate reductase large subunit1.17.4.10.442
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.442
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.442
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.442
3gwfFADCyclohexanone monooxygenase/0.442
3mtlFEFCyclin-dependent kinase 162.7.11.220.442
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.442
3t8vBTJM1 family aminopeptidase3.4.110.442
3uyt0CKCasein kinase I isoform delta2.7.11.10.442
3vf80JETyrosine-protein kinase SYK2.7.10.20.442
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.442
3zewSTUEphrin type-B receptor 42.7.10.10.442
4bfxZVXPantothenate kinase2.7.1.330.442
4c61LMMTyrosine-protein kinase JAK2/0.442
4ezl0SEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4fgrADPPhosphoribosylaminoimidazole-succinocarboxamide synthase6.3.2.60.442
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.442
4hnc0UTMandelate racemase/0.442
4hw219HInduced myeloid leukemia cell differentiation protein Mcl-1/0.442
4jqh1MFAlr2278 protein/0.442
4knnE1FCarbonic anhydrase 134.2.1.10.442
4rrmA3TProbable threonine--tRNA ligase 26.1.1.30.442
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.442
5dosATPAurora kinase A2.7.11.10.442
5lc1NADL-threonine 3-dehydrogenase/0.442
3qakUKAAdenosine receptor A2a/0.442
1d3hA26Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.441
1db48INPhospholipase A2, membrane associated/0.441
1dr3HBIDihydrofolate reductase1.5.1.30.441
1e1kFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.441
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
1hw5CMPcAMP-activated global transcriptional regulator CRP/0.441
1iyzNDPProbable quinone oxidoreductase/0.441
1kl2FONSerine hydroxymethyltransferase/0.441
1ndzFR5Adenosine deaminase3.5.4.40.441
1pjkANPCasein kinase II subunit alpha2.7.11.10.441
1uykPUXHeat shock protein HSP 90-alpha/0.441
1xzqFONtRNA modification GTPase MnmE3.6.50.441
2h94FADLysine-specific histone demethylase 1A10.441
2i5bADPPyridoxine kinase/0.441
2igoFADPyranose 2-oxidase/0.441
2np8CC3Aurora kinase A2.7.11.10.441
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.441
3at3ATKCasein kinase II subunit alpha2.7.11.10.441
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.441
3lctADPALK tyrosine kinase receptor2.7.10.10.441
3nj0PYVAbscisic acid receptor PYL2/0.441
3qlzQLZUncharacterized protein/0.441
3qm4PN0Cytochrome P450 2D6/0.441
3wgwT2BProliferating cell nuclear antigen/0.441
4fod0UVALK tyrosine kinase receptor2.7.10.10.441
4hj3FMNLOV protein/0.441
4hvg19QTyrosine-protein kinase JAK32.7.10.20.441
4i22IREEpidermal growth factor receptor2.7.10.10.441
4i5i4I5NAD-dependent protein deacetylase sirtuin-13.5.10.441
4j97ACPFibroblast growth factor receptor 2/0.441
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.441
4kb81QOCasein kinase I isoform delta2.7.11.10.441
4oavACP2-5A-dependent ribonuclease3.1.260.441
4p6wMOFGlucocorticoid receptor/0.441
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.441
4uj3GNPRas-related protein Rab-11A/0.441
4xoiGTPTransforming protein RhoA/0.441
6coxS58Prostaglandin G/H synthase 21.14.99.10.441
1gs4ZK5Androgen receptor/0.440
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.440
1m2rMNYCasein kinase II subunit alpha2.7.11.10.440
1rx3MTXDihydrofolate reductase1.5.1.30.440
1synF89Thymidylate synthase/0.440
1xe55FEPlasmepsin-23.4.23.390.440
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.440
2e1mFADL-glutamate oxidase/0.440
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.440
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.440
2npnSAMPutative cobalamin synthesis related protein/0.440
2rhtC1E2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase3.7.1.80.440
3awhFMNFMN-binding protein/0.440
3b6zCO7Enoyl reductase LovC10.440
3cz09ODPheromone-binding protein ASP1/0.440
3dokGWJPol protein/0.440
3fwiCAMCamphor 5-monooxygenase1.14.15.10.440
3ii43IIDihydrolipoyl dehydrogenase1.8.1.40.440
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3ocpCMPcGMP-dependent protein kinase 12.7.11.120.440
3oeyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
3opdHIEHeat shock protein 83/0.440
3rk507ZCyclin-dependent kinase 22.7.11.220.440
3vjhJ35Peroxisome proliferator-activated receptor gamma/0.440
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.440
4aguD15Cyclin-dependent kinase-like 1/0.440
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
4cukNAID-lactate dehydrogenase/0.440
4dp3MMVBifunctional dihydrofolate reductase-thymidylate synthase/0.440
4e4m0NHTyrosine-protein kinase JAK2/0.440
4ja81K9Isocitrate dehydrogenase [NADP], mitochondrial1.1.1.420.440
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.440
4pdaCTNNucleoside permease/0.440
4q73FADBifunctional protein PutA/0.440
4qysPLRTryptophan synthase beta chain 24.2.1.200.440
4riyADPEpidermal growth factor receptor2.7.10.10.440
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.440
5jtbZMAAdenosine receptor A2a/0.440