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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fakSAMRibosomal RNA large subunit methyltransferase H

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fakSAMRibosomal RNA large subunit methyltransferase H/1.000
1jhrP2PNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.519
1l4mNCNNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.519
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.505
3n4kSAHtRNA (cytidine(34)-2'-O)-methyltransferase/0.503
3kjm245Cytokinin dehydrogenase 11.5.99.120.500
2z0ySAMRibosomal RNA small subunit methyltransferase E/0.496
5koiNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.492
2ag1TPPBenzaldehyde lyase/0.491
3r9uFADThioredoxin reductase/0.490
5c77SAHProtein arginine N-methyltransferase SFM1/0.490
4an4DUDPutative glycosyl transferase/0.486
2a1mCAMCamphor 5-monooxygenase1.14.15.10.485
2yy8SAMtRNA (cytidine(56)-2'-O)-methyltransferase/0.484
3h8bNSYCathepsin L13.4.22.150.484
1ualSAHtRNA (guanine-N(1)-)-methyltransferase2.1.1.2280.483
3lsiFADPyranose 2-oxidase/0.483
4du82P0Mevalonate diphosphate decarboxylase/0.482
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.481
3a14NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.481
3dds26BGlycogen phosphorylase, liver form2.4.1.10.481
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.480
4mcd22LtRNA (guanine-N(1)-)-methyltransferase2.1.1.2280.480
1phePIYCamphor 5-monooxygenase1.14.15.10.479
2o2sTCLEnoyl-acyl carrier reductase/0.479
2p6iSAHDiphthine synthase/0.479
4l4cCAMCamphor 5-monooxygenase1.14.15.10.479
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.479
1y7lASN_LEU_ASN_ILECysteine synthase2.5.1.470.478
3eqlMXPDNA-directed RNA polymerase subunit beta/0.478
3eqlMXPDNA-directed RNA polymerase subunit beta'/0.478
3hyz42CHeat shock protein HSP 90-alpha/0.477
5fwnNAPPutative dehydrogenase/0.477
2dv7SAHDiphthine synthase/0.476
2el3SAHDiphthine synthase/0.476
4o2bLOCTubulin beta-2B chain/0.476
1qy5NECEndoplasmin/0.475
3gviADPMalate dehydrogenase/0.474
4fkv61KCyclin-dependent kinase 22.7.11.220.474
1a72PADAlcohol dehydrogenase E chain1.1.1.10.473
2dsgSAHDiphthine synthase/0.473
2emrSAHDiphthine synthase/0.473
3l63CAMCamphor 5-monooxygenase1.14.15.10.473
2oaxSNLMineralocorticoid receptor/0.472
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.472
3mdmFJZCholesterol 24-hydroxylase/0.472
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.472
4xboSAHtRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ2.1.1.2000.472
3nwxKVSGag-Pol polyprotein3.4.23.160.471
1aj8COACitrate synthase/0.470
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.470
3fwjCAMCamphor 5-monooxygenase1.14.15.10.470
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.470
4xgxADPFAD:protein FMN transferase/0.470
1dr3TAPDihydrofolate reductase1.5.1.30.469
1mewXMPInosine-5'-monophosphate dehydrogenase/0.469
1wn3HXCPhenylacetic acid degradation protein PaaI/0.469
2cgpCMPcAMP-activated global transcriptional regulator CRP/0.469
3wv9FEGHmd co-occurring protein HcgE/0.469
4k28NADShikimate dehydrogenase family protein/0.469
4yvjSFGtRNA (guanine-N(1)-)-methyltransferase2.1.1.2280.469
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.468
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.468
3oibFDAPutative acyl-CoA dehydrogenase/0.468
4cnfMTASpoU rRNA methylase/0.468
5a9sNAPPutative dehydrogenase/0.468
1cbfSAHCobalt-precorrin-4 C(11)-methyltransferase2.1.1.2710.467
1o76CAMCamphor 5-monooxygenase1.14.15.10.467
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.467
2vkeTACTetracycline repressor protein class D/0.467
2xd6XD6ATP-dependent molecular chaperone HSP82/0.467
3otfCMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4/0.467
4ig6SAHtRNA (guanine-N(1)-)-methyltransferase/0.467
1l4kNCNNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.466
2a1oCAMCamphor 5-monooxygenase1.14.15.10.466
2ed5SAHDiphthine synthase/0.466
3eljGS7Mitogen-activated protein kinase 82.7.11.240.466
3zh8C58Protein kinase C iota type2.7.11.130.466
4gk2L66Ephrin type-A receptor 32.7.10.10.466
4jalSAHtRNA (cytidine(34)-2'-O)-methyltransferase/0.466
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.465
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.465
1d7aAIRN5-carboxyaminoimidazole ribonucleotide mutase/0.464
1gebCAMCamphor 5-monooxygenase1.14.15.10.464
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.464
1lsoNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.464
1qrpHH0Pepsin A-43.4.23.10.464
3gwfFADCyclohexanone monooxygenase/0.464
3lqfNADGalactitol dehydrogenase/0.464
3lshFADPyranose 2-oxidase/0.464
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.464
1dz4CAMCamphor 5-monooxygenase1.14.15.10.463
1g4tFTPThiamine-phosphate synthase/0.463
1yc443PHeat shock protein HSP 90-alpha/0.463
2e15SAHDiphthine synthase/0.463
2huxSAHDiphthine synthase/0.463
3a1nNADNDP-sugar epimerase/0.463
4xj43ATCyclic GMP-AMP synthase/0.463
1dhiMTXDihydrofolate reductase1.5.1.30.462
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.462
2dv3SAHDiphthine synthase/0.462
2dxxSAHDiphthine synthase/0.462
2g5cNADPrephenate dehydrogenase/0.462
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.462
2jlcTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.462
2m56CAMCamphor 5-monooxygenase1.14.15.10.462
2p6lSAHDiphthine synthase/0.462
3cgbCOACoenzyme A disulfide reductase/0.462
3cppCAMCamphor 5-monooxygenase1.14.15.10.462
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.462
1ml6GBXGlutathione S-transferase A22.5.1.180.461
1uyuCAMCamphor 5-monooxygenase1.14.15.10.461
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.461
2jlaTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.461
3d2mCOAAmino-acid acetyltransferase/0.461
3kb1ADPIron-sulfur cluster carrier protein/0.461
4bmpFMNProtein NrdI/0.461
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.461
4kgnSAHtRNA (cytidine(34)-2'-O)-methyltransferase/0.461
1l4fNCNNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.460
1l4lNCNNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.460
1qnfFADDeoxyribodipyrimidine photo-lyase4.1.99.30.460
1ra8FOLDihydrofolate reductase1.5.1.30.460
3ansS38Bifunctional epoxide hydrolase 23.3.2.100.460
3fhxPXLPyridoxal kinase2.7.1.350.460
3hx4ANPCalmodulin-domain protein kinase 1/0.460
3stuDK3Methylketone synthase I/0.460
3t3q9PLCytochrome P450 2A61.14.130.460
4eh60ONMitogen-activated protein kinase 14/0.460
4gk3L87Ephrin type-A receptor 32.7.10.10.460
4pleCPSNuclear receptor subfamily 5 group A member 2/0.460
1ep1FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit1.3.1.140.459
1fm7DFVChalcone--flavonone isomerase 15.5.1.60.459
1iwiCAMCamphor 5-monooxygenase1.14.15.10.459
1p0hACOMycothiol acetyltransferase2.3.1.1890.459
1pdhFASp-hydroxybenzoate hydroxylase/0.459
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
1uamSAHtRNA (guanine-N(1)-)-methyltransferase2.1.1.2280.459
2b7aIZATyrosine-protein kinase JAK2/0.459
2e8hSAHDiphthine synthase/0.459
2eh4SAHDiphthine synthase/0.459
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.459
2qfoA13Heat shock protein HSP 90-alpha/0.459
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.459
3pxvFMNNitroreductase/0.459
3zuyTCHTransporter/0.459
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.459
4kgkGTPUncharacterized protein/0.459
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.459
4v2gITCTetracycline repressor protein class D/0.459
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.459
1vsvNADGlyceraldehyde-3-phosphate dehydrogenase/0.458
2a1y5GPGMP reductase/0.458
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.458
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.458
2y0mACOHistone acetyltransferase KAT8/0.458
2yee2ECHeat shock protein HSP 90-alpha/0.458
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.458
3i81EBIInsulin-like growth factor 1 receptor2.7.10.10.458
3uu114BAnthranilate phosphoribosyltransferase/0.458
4awo99BHeat shock protein HSP 90-alpha/0.458
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.458
1h74ADPHomoserine kinase2.7.1.390.457
1rx1NAPDihydrofolate reductase1.5.1.30.457
1uyhPU0Heat shock protein HSP 90-alpha/0.457
1vp6CMPCyclic nucleotide-gated potassium channel mll3241/0.457
2a94AP0L-lactate dehydrogenase1.1.1.270.457
2c31TZDOxalyl-CoA decarboxylase4.1.1.80.457
2werRDCATP-dependent molecular chaperone HSP82/0.457
3ajrNADNDP-sugar epimerase/0.457
3gb4D3MDdmC/0.457
3phiNDPShikimate dehydrogenase (NADP(+))/0.457
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.457
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.457
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.457
4pkwGM6Lethal factor3.4.24.830.457
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.456
2e16SAHDiphthine synthase/0.456
2givACOHistone acetyltransferase KAT8/0.456
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.456
2yy8MTAtRNA (cytidine(56)-2'-O)-methyltransferase/0.456
3a3gDLZLumazine protein/0.456
4dpy2P0Mevalonate diphosphate decarboxylase/0.456
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
4l4eCAMCamphor 5-monooxygenase1.14.15.10.456
4qq3XMPInosine-5'-monophosphate dehydrogenase/0.456
5cvcPLPSerine racemase/0.456
1hdrNADDihydropteridine reductase1.5.1.340.455
1t85CAMCamphor 5-monooxygenase1.14.15.10.455
1uxjNADMalate dehydrogenase/0.455
1vjy460TGF-beta receptor type-12.7.11.300.455
2aqjFADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.455
2e4nSAHDiphthine synthase/0.455
2e8rSAHDiphthine synthase/0.455
2hutSAHDiphthine synthase/0.455
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.455
2pb6SAHDiphthine synthase/0.455
3gxlQIGTGF-beta receptor type-12.7.11.300.455
4awp99AHeat shock protein HSP 90-alpha/0.455
4l4aCAMCamphor 5-monooxygenase1.14.15.10.455
4nb6444Nuclear receptor ROR-gamma/0.455
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.455
1dhrNADDihydropteridine reductase1.5.1.340.454
1dr3HBIDihydrofolate reductase1.5.1.30.454
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.454
1l4hNCNNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.454
1uy9PU6Heat shock protein HSP 90-alpha/0.454
2e07SAHDiphthine synthase/0.454
2eh2SAHDiphthine synthase/0.454
2ek4SAHDiphthine synthase/0.454
2gz8F3FOrf1a polyprotein/0.454
2h55DZ8Heat shock protein HSP 90-alpha/0.454
2owuSAHDiphthine synthase/0.454
2qbmCAMCamphor 5-monooxygenase1.14.15.10.454
3a9wNADNDP-sugar epimerase/0.454
3fwiCAMCamphor 5-monooxygenase1.14.15.10.454
3rnnRNNGlutamate receptor 2/0.454
4hvg19QTyrosine-protein kinase JAK32.7.10.20.454
4inb1F6Gag protein/0.454
4l4dCAMCamphor 5-monooxygenase1.14.15.10.454
5e8wSTUTGF-beta receptor type-12.7.11.300.454
1d0vRBZNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.453
1hwzNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.453
1l4gNCNNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.453
2ykeYKEHeat shock protein HSP 90-alpha/0.453
2zbaZBATrichothecene 3-O-acetyltransferase/0.453
3bbhSFGRibosomal RNA small subunit methyltransferase Nep12.1.10.453
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.453
3nwq2NCGag-Pol polyprotein3.4.23.160.453
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.453
3t10ACPHeat shock protein HSP 90-alpha/0.453
4c02TAKActivin receptor type-12.7.11.300.453
4cdmFO1Deoxyribodipyrimidine photolyase/0.453
4egh0OYHeat shock protein HSP 90-alpha/0.453
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.453
4nm9FADBifunctional protein PutA/0.453
4tuvCPZCytochrome P450 1191.140.453
5a1tNAIL-lactate dehydrogenase/0.453
5e8ySTUTGF-beta receptor type-22.7.11.300.453
5fkmTDCTetracycline repressor protein class D/0.453
1bwsNDPGDP-L-fucose synthase/0.452
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
1g6kNADGlucose 1-dehydrogenase1.1.1.470.452
1l3iSAHProbable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)/0.452
1me6IVSPlasmepsin-23.4.23.390.452
1nhhANPDNA mismatch repair protein MutL/0.452
1ra3MTXDihydrofolate reductase1.5.1.30.452
1t87CAMCamphor 5-monooxygenase1.14.15.10.452
1t88CAMCamphor 5-monooxygenase1.14.15.10.452
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.452
2dekSAHDiphthine synthase/0.452
2el0SAHDiphthine synthase/0.452
2huqSAHDiphthine synthase/0.452
2wi2ZZ3Heat shock protein HSP 90-alpha/0.452
2z6rSAHDiphthine synthase/0.452
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.452
3dd125DGlycogen phosphorylase, liver form2.4.1.10.452
3fwfCAMCamphor 5-monooxygenase1.14.15.10.452
3iqgASN_TRP_ASN_ILECysteine synthase2.5.1.470.452
3pe6ZYHMonoglyceride lipase/0.452
3pl8FADPyranose 2-oxidase/0.452
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
4c04SFGProtein arginine N-methyltransferase 6/0.452
4c0bATPmRNA cleavage and polyadenylation factor CLP1/0.452
4eh70OOMitogen-activated protein kinase 14/0.452
4g95OAGDihydrofolate reductase1.5.1.30.452
4l49CAMCamphor 5-monooxygenase1.14.15.10.452
1dirNADDihydropteridine reductase1.5.1.340.451
1fwkADPHomoserine kinase2.7.1.390.451
1ipeNDPTropinone reductase 21.1.1.2360.451
1meiXMPInosine-5'-monophosphate dehydrogenase/0.451
1orhSAHProtein arginine N-methyltransferase 1/0.451
1qy8RDIEndoplasmin/0.451
1uycPU7Heat shock protein HSP 90-alpha/0.451
1y9dTPPPyruvate oxidase1.2.3.30.451
2c6tDT5Cyclin-dependent kinase 22.7.11.220.451
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.451
2e17SAHDiphthine synthase/0.451
2ek2SAHDiphthine synthase/0.451
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.451
2pcaSAHDiphthine synthase/0.451
3gdvTYR_GLN_PHESerine endoprotease DegS3.4.21.1070.451
3mvqNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.451
4ewhT77Activated CDC42 kinase 1/0.451
4jc51K5Stimulator of interferon genes protein/0.451
4kiq1RAMitogen-activated protein kinase 14/0.451
4mcc21XtRNA (guanine-N(1)-)-methyltransferase2.1.1.2280.451
4mgiCMPRap guanine nucleotide exchange factor 4/0.451
4u0mGTPCyclic GMP-AMP synthase/0.451
1bifAGS6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 42.7.1.1050.450
1dr5NAPDihydrofolate reductase1.5.1.30.450
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
1g69TZPThiamine-phosphate synthase/0.450
1kt8ILPBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.450
1kvkATPMevalonate kinase2.7.1.360.450
1m51TSXPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.450
2ek3SAHDiphthine synthase/0.450
2eldSAHDiphthine synthase/0.450
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.450
2qboCAMCamphor 5-monooxygenase1.14.15.10.450
2yk2YJWHeat shock protein HSP 90-alpha/0.450
2z97CAMCamphor 5-monooxygenase1.14.15.10.450
3fpjSAMUncharacterized protein/0.450
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.450
3nj0PYVAbscisic acid receptor PYL2/0.450
4kba1QMCasein kinase I isoform delta2.7.11.10.450
5mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.450
1dyhDZFDihydrofolate reductase1.5.1.30.449
1nf7RVPInosine-5'-monophosphate dehydrogenase 2/0.449
1u71MXADihydrofolate reductase1.5.1.30.449
1xe65FPPlasmepsin-23.4.23.390.449
2a1hGBNBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.449
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.449
2e83FMNFMN-binding protein/0.449
2eglSAHDiphthine synthase/0.449
2fypRDEEndoplasmin/0.449
2iwsNP4ATP-dependent molecular chaperone HSP82/0.449
2pckSAHDiphthine synthase/0.449
2yegXQGHeat shock protein HSP 90-alpha/0.449
2znnS44Peroxisome proliferator-activated receptor alpha/0.449
3a4vNADNDP-sugar epimerase/0.449
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.449
3hk1B64Fatty acid-binding protein, adipocyte/0.449
3oeyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
3zewSTUEphrin type-B receptor 42.7.10.10.449
4aotGW8Serine/threonine-protein kinase 102.7.11.10.449
4c9pCAMCytochrome P450/0.449
4cp4CAMCamphor 5-monooxygenase1.14.15.10.449
4e93GUITyrosine-protein kinase Fes/Fps2.7.10.20.449
4eji0QACytochrome P450 2A131.14.14.10.449
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.449
4g3e0WCMitogen-activated protein kinase kinase kinase 142.7.11.250.449
4ke11R6Beta-secretase 13.4.23.460.449
5cp4CAMCamphor 5-monooxygenase1.14.15.10.449
1e8xATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
1i8tFADUDP-galactopyranose mutase5.4.99.90.448
1mjaCOAHistone acetyltransferase ESA1/0.448
1rx8NAPDihydrofolate reductase1.5.1.30.448
1wngSAHDiphthine synthase/0.448
1xddAAYIntegrin alpha-L/0.448
1ykdCMPAdenylate cyclase/0.448
1yrcCAMCamphor 5-monooxygenase1.14.15.10.448
2bz5AB4Heat shock protein HSP 90-alpha/0.448
2czfXMPOrotidine 5'-phosphate decarboxylase4.1.1.230.448
2gr0FADFerredoxin reductase/0.448
2nv4SAMS-adenosyl-L-methionine-binding protein AF_0241/0.448
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.448
2p5fSAHDiphthine synthase/0.448
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.448
2x9fX9FEphrin type-B receptor 42.7.10.10.448
2z54AB1Gag-Pol polyprotein3.4.23.160.448
3adaNADSubunit alpha of sarocosine oxidase/0.448
3d3wNAPL-xylulose reductase1.1.1.100.448
3ekoPYUHeat shock protein HSP 90-alpha/0.448
3gggNADPrephenate dehydrogenase/0.448
3gvhNADMalate dehydrogenase/0.448
3iw1ASDSteroid C26-monooxygenase1.14.13.1410.448
3lxiCAMCytochrome P450/0.448
3mdvCL6Cholesterol 24-hydroxylase/0.448
3qlrNDPDihydrofolate reductase1.5.1.30.448
3wrjCAMCamphor 5-monooxygenase1.14.15.10.448
4apuA2KProgesterone receptor/0.448
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.448
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.448
4hy6FJ1Heat shock protein HSP 90-alpha/0.448
4jloADPAdenylate kinase/0.448
4jwfSAHtRNA (guanine(9)-N1)-methyltransferase/0.448
4kin1M8Mitogen-activated protein kinase 14/0.448
4kqwNAPKetol-acid reductoisomerase (NADP(+))/0.448
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.448
4uyf73BBromodomain-containing protein 2/0.448
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
6cp4CAMCamphor 5-monooxygenase1.14.15.10.448
5dhgDGVNociceptin receptor/0.448
1a8pFADFerredoxin--NADP reductase/0.447
1cjtFOKAdenylate cyclase type 2/0.447
1cjtFOKAdenylate cyclase type 5/0.447
1dz6CAMCamphor 5-monooxygenase1.14.15.10.447
1ia1NDPDihydrofolate reductase1.5.1.30.447
1ml3NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.447
1wntNAPL-xylulose reductase1.1.1.100.447
1xny191Propionyl-CoA carboxylase complex B subunit/0.447
2bi8FADUDP-galactopyranose mutase5.4.99.90.447
2c12FADNitroalkane oxidase1.7.3.10.447
2e7rSAHDiphthine synthase/0.447
2emuSAHDiphthine synthase/0.447
2qdxFADFerredoxin--NADP+ reductase/0.447
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
2y6o1N1Ephrin type-A receptor 42.7.10.10.447
3bbdSAHRibosomal RNA small subunit methyltransferase Nep12.1.10.447
3bg7FADPyranose 2-oxidase/0.447
3cgdCOACoenzyme A disulfide reductase/0.447
3drcMTXDihydrofolate reductase1.5.1.30.447
3hl7I47Mitogen-activated protein kinase 14/0.447
3k6l2BBPeptide deformylase3.5.1.880.447
3ndcSAHPrecorrin-4 C(11)-methyltransferase2.1.1.1330.447
3o153NMThiamine-phosphate synthase/0.447
3qdqCOA4-Hydroxybutyrate CoA-transferase/0.447
3tk0FADFAD-linked sulfhydryl oxidase ALR1.8.3.20.447
4bqh9VUUDP-N-acetylglucosamine pyrophosphorylase, putative/0.447
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.447
4i8vBHFCytochrome P450 1A11.14.14.10.447
4ly91YYGlucokinase regulatory protein/0.447
4opgFDAConserved Archaeal protein/0.447
4otpADPSerine/threonine-protein kinase RIO12.7.11.10.447
5a3bAPRSIR2 family protein/0.447
5hs1VORLanosterol 14-alpha demethylase/0.447
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.446
1ezvUQ6Cytochrome b/0.446
1ihxSNDGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.446
1l5k1RBNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.446
1phgMYTCamphor 5-monooxygenase1.14.15.10.446
1tqf32PBeta-secretase 13.4.23.460.446
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.446
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
2breKJ2ATP-dependent molecular chaperone HSP82/0.446
2btdADPPEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL2.70.446
2bxmIMNSerum albumin/0.446
2drcMTXDihydrofolate reductase1.5.1.30.446
2nniMTKCytochrome P450 2C8/0.446
2p9dSAHDiphthine synthase/0.446
2vv9IM9Cyclin-dependent kinase 22.7.11.220.446
2w4kADPDeath-associated protein kinase 12.7.11.10.446
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.446
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
3h3r14HCollagen type IV alpha-3-binding protein/0.446
3oafOAGDihydrofolate reductase1.5.1.30.446
3r8814FAnthranilate phosphoribosyltransferase/0.446
4hj6FMNLOV protein/0.446
4hxyNDPPlm1/0.446
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.446
5dw60T1Succinyl-CoA:acetate CoA-transferase/0.446
1diuBDMDihydrofolate reductase1.5.1.30.445
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.445
1i58ACPChemotaxis protein CheA2.7.13.30.445
1q6yCOAFormyl-CoA:oxalate CoA-transferase/0.445
1rx7FOLDihydrofolate reductase1.5.1.30.445
1uy8PU5Heat shock protein HSP 90-alpha/0.445
1uymPU3Heat shock protein HSP 90-beta/0.445
2bgiFADNADPH:ferredoxin reductase/0.445
2dsiSAHDiphthine synthase/0.445
2ibwCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.445
2wkmPFYHepatocyte growth factor receptor2.7.10.10.445
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.445
2yy7NADL-threonine dehydrogenase/0.445
3a6rFMNFMN-binding protein/0.445
3bhtMFRCyclin-dependent kinase 22.7.11.220.445
3da1FADGlycerol-3-phosphate dehydrogenase/0.445
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3ibqATPPyridoxal kinase/0.445
3ijdC2FMethylenetetrahydrofolate reductase/0.445
3iqhTYR_ASP_ILECysteine synthase2.5.1.470.445
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.445
3pj8404Cyclin-dependent kinase 22.7.11.220.445
3rak03ZCyclin-dependent kinase 22.7.11.220.445
3wswNADL-lactate dehydrogenase/0.445
3zc5W9ZHepatocyte growth factor receptor2.7.10.10.445
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.445
4cukNAID-lactate dehydrogenase/0.445
4ek1CAMCamphor 5-monooxygenase1.14.15.10.445
4g3rCAMCamphor 5-monooxygenase1.14.15.10.445
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.445
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.445
4kos4KOUncharacterized protein/0.445
4nbwNADShort-chain dehydrogenase/reductase SDR/0.445
1dr2TAPDihydrofolate reductase1.5.1.30.444
1h2hNADL-aspartate dehydrogenase1.4.1.210.444
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1nhtPGSAdenylosuccinate synthetase/0.444
1uy7PU4Heat shock protein HSP 90-alpha/0.444
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
2cig1DGDihydrofolate reductase1.5.1.30.444
2e8qSAHDiphthine synthase/0.444
2feuCAMCamphor 5-monooxygenase1.14.15.10.444
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.444
2rhgIGPTryptophan synthase alpha chain/0.444
2rkfAB1Pol protein/0.444
2tctCTCTetracycline repressor protein class D/0.444
3a0tADPSensor histidine kinase/0.444
4ajp88NL-lactate dehydrogenase A chain1.1.1.270.444
4aknS5BBromodomain-containing protein 2/0.444
4er6AW2Histone-lysine N-methyltransferase, H3 lysine-79 specific2.1.1.430.444
4g2fC07Ephrin type-A receptor 32.7.10.10.444
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4h4qFADBiphenyl dioxygenase ferredoxin reductase subunit/0.444
4hvi19STyrosine-protein kinase JAK32.7.10.20.444
4kne1CYDihydrofolate reductase1.5.1.30.444
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.444
1bofGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.443
1g1aNADdTDP-glucose 4,6-dehydratase/0.443
1iy8NADLevodione reductase/0.443
1mvsDTMDihydrofolate reductase1.5.1.30.443
1pd9CO4Dihydrofolate reductase1.5.1.30.443
1rctNOSPurine nucleoside phosphorylase2.4.2.10.443
1rf7DHFDihydrofolate reductase1.5.1.30.443
1suoCPZCytochrome P450 2B41.14.14.10.443
1zemNADXylitol dehydrogenase/0.443
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.443
2favAPRNonstructural polyprotein pp1a/0.443
2fde385Gag-Pol polyprotein3.4.23.160.443
2fj1CTCTetracycline repressor protein class D/0.443
2gfdRDAEndoplasmin/0.443
2pchSAHDiphthine synthase/0.443
2qo9ANPEphrin type-A receptor 32.7.10.10.443
2w3bNDPDihydrofolate reductase1.5.1.30.443
3gobHXXDdmC/0.443
3h06VBPGlutamate receptor 2/0.443
3koo24DBifunctional epoxide hydrolase 23.3.2.100.443
3mvm39PMitogen-activated protein kinase 14/0.443
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.443
4ajn88VL-lactate dehydrogenase A chain1.1.1.270.443
4fmxCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.443
4njoNADD-3-phosphoglycerate dehydrogenase, putative/0.443
1drhNAPDihydrofolate reductase1.5.1.30.442
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.442
1eyqNARChalcone--flavonone isomerase 15.5.1.60.442
1rw8580TGF-beta receptor type-12.7.11.300.442
1sowNADL-lactate dehydrogenase1.1.1.270.442
1um8ADPATP-dependent Clp protease ATP-binding subunit ClpX/0.442
1w2xRCPAcetyl-CoA carboxylase/0.442
2cvjFADThioredoxin reductase related protein/0.442
2dv5SAHDiphthine synthase/0.442
2dxvSAHDiphthine synthase/0.442
2hqpNDPDihydrofolate reductase1.5.1.30.442
2hu2NADC-terminal binding protein 1/0.442
2mm3CHOGastrotropin/0.442
2rhrEMOPutative ketoacyl reductase1.3.10.442
2vd5BI8Myotonin-protein kinase2.7.11.10.442
2vprTDCTetracycline repressor protein class H/0.442
2wyaHMGHydroxymethylglutaryl-CoA synthase, mitochondrial2.3.3.100.442
2ylzFADPhenylacetone monooxygenase1.14.13.920.442
2z6jTUI2-nitropropane dioxygenase/0.442
2znq401Peroxisome proliferator-activated receptor delta/0.442
3am4FT1Enoyl-ACP reductase/0.442
3au8NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic1.1.1.2670.442
3ddw055Glycogen phosphorylase, liver form2.4.1.10.442
3i6oGR6Gag-Pol polyprotein3.4.23.160.442
3rmf20ZCyclin-dependent kinase 22.7.11.220.442
3t3r9PLCytochrome P450 2A61.14.130.442
3w0hW12Vitamin D3 receptor/0.442
4egnTWOCytochrome P450/0.442
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.442
4g2rH1LProbable propionyl-CoA carboxylase beta chain 66.4.1.30.442
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.442
4lsl1YQGag-Pol polyprotein2.7.7.490.442
4m6jNDPDihydrofolate reductase1.5.1.30.442
4nh82LCHeat shock protein HSP 90-alpha/0.442
4obuPLPPyridoxal-dependent decarboxylase domain protein/0.442
4prxADPDNA gyrase subunit B/0.442
4z1fH71Heat shock protein 75 kDa, mitochondrial/0.442
1a9yUPGUDP-glucose 4-epimerase5.1.3.20.441
1dbvNADGlyceraldehyde-3-phosphate dehydrogenase/0.441
1dq8COA3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.441
1dyjDDFDihydrofolate reductase1.5.1.30.441
1gilGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.441
1me7RVPInosine-5'-monophosphate dehydrogenase/0.441
1rx8FOLDihydrofolate reductase1.5.1.30.441
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.441
2c29NAPDihydroflavonol 4-reductase/0.441
2ci01CMLanosterol 14-alpha demethylase1.14.13.700.441
2gjnFMNNitronate monooxygenase1.13.12.160.441
2hjrAPRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase/0.441
2itzIREEpidermal growth factor receptor2.7.10.10.441
2ji9TPWOxalyl-CoA decarboxylase4.1.1.80.441
2q9fC3SCholesterol 24-hydroxylase/0.441
2v59LZKBiotin carboxylase6.3.4.140.441
2wo7ASVIsopenicillin N synthase1.21.3.10.441
2zdxP4A[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.441
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.441
3btsNADGalactose/lactose metabolism regulatory protein GAL80/0.441
3ecg065Gag-Pol polyprotein3.4.23.470.441
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
3o15IFPThiamine-phosphate synthase/0.441
3tjzGNPADP-ribosylation factor 1/0.441
3zu2NAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.441
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.441
4dfrMTXDihydrofolate reductase1.5.1.30.441
4duhRLIDNA gyrase subunit B/0.441
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.441
4jhz1KVBeta-glucuronidase3.2.1.310.441
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.441
1ay0TPPTransketolase 12.2.1.10.440
1b16NAQAlcohol dehydrogenase1.1.1.10.440
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
1g28FMNPHY3/0.440
1gleADPGlycerol kinase/0.440
1iwjCAMCamphor 5-monooxygenase1.14.15.10.440
1lf3EH5Plasmepsin-23.4.23.390.440
1m78NDPDihydrofolate reductase1.5.1.30.440
1t3r017Gag-Pol polyprotein3.4.23.160.440
1y0s331Peroxisome proliferator-activated receptor delta/0.440
1zrzBI1Protein kinase C iota type2.7.11.130.440
2avvMK1Gag-Pol polyprotein3.4.23.160.440
2aznNAP2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase/0.440
2bunFADAppA protein/0.440
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.440
2ejjSAHDiphthine synthase/0.440
2ek7SAHDiphthine synthase/0.440
2en5SAHDiphthine synthase/0.440
2hr8SAHDiphthine synthase/0.440
2huvSAHDiphthine synthase/0.440
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.440
2wd9IBPAcyl-coenzyme A synthetase ACSM2A, mitochondrial6.2.1.20.440
2x0iNAIMalate dehydrogenase/0.440
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.440
2y3sTIRTamL/0.440
3hekBD0Heat shock protein HSP 90-alpha/0.440
3rn8RN8Glutamate receptor 2/0.440
3rqqBA3ADP-dependent (S)-NAD(P)H-hydrate dehydratase/0.440
3tjsD0RCytochrome P450 3A4/0.440
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.440
4c9oCAMCytochrome P450/0.440
4dbzNDPPutative ketoacyl reductase1.3.10.440
4ejgNCTCytochrome P450 2A131.14.14.10.440
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.440
4gsuDWZL,D-transpeptidase 22.3.20.440
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.440
4hnc0UTMandelate racemase/0.440
4i6gFADCryptochrome-2/0.440
4oe4NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.880.440
4s32ANPMitogen-activated protein kinase 12.7.11.240.440
5dp2NAPCurF/0.440