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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2bmeGNPRas-related protein Rab-4A

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2bmeGNPRas-related protein Rab-4A/1.000
1yu9GNPRas-related protein Rab-4A/0.623
4lrwGDPGTPase KRas/0.602
4ql3GDPGTPase KRas/0.597
1n6lGTPRas-related protein Rab-5A/0.596
4q03GDPGTPase KRas/0.596
4obeGDPGTPase KRas/0.595
3tgpGNPGTPase HRas/0.589
2fe4GDPRas-related protein Rab-6B/0.587
2fg5GNPRas-related protein Rab-31/0.585
2rggGNPGTPase HRas/0.579
4tq9GDPGTPase KRas/0.579
4epxGDPGTPase KRas/0.575
4l9sGDPGTPase HRas/0.575
3kkoGNPRas-related protein M-Ras/0.572
3qbtGNPRas-related protein Rab-8A/0.572
4uj5GNPRas-related protein Rab-11A/0.572
4lpkGDPGTPase KRas/0.571
4uj3GNPRas-related protein Rab-11A/0.571
4lhwGNPRas-related protein Rab-8A/0.570
3cphGDPRas-related protein SEC4/0.569
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.566
4q02GDPGTPase KRas/0.564
4qxaGTPRas-related protein Rab-9A/0.562
4l8gGDPGTPase KRas/0.560
4ldjGDPGTPase KRas/0.559
4lv6GDPGTPase KRas/0.559
4epwGDPGTPase KRas/0.558
4o2rGDPGTP-binding protein Rheb/0.556
5c46GSPRas-related protein Rab-11A/0.556
1x1rGDPRas-related protein M-Ras/0.553
3pitGNPRas-related protein M-Ras/0.553
3tsoGNPRas-related protein Rab-25/0.553
3ddcGNPGTPase HRas/0.552
4xvqGNPGTPase HRas/0.551
1uadGNPRas-related protein Ral-A/0.550
1tu3GNPRas-related protein Rab-5A/0.549
2q3fGNPRas-related GTP-binding protein D/0.548
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.545
3kkqGDPRas-related protein M-Ras/0.545
1xtsGTPGTP-binding protein Rheb/0.543
1zd9GDPADP-ribosylation factor-like protein 8A/0.543
4hdqGNPRas-related protein Rap-1b/0.543
4lucGDPGTPase KRas/0.539
3mjhGTPRas-related protein Rab-5A/0.537
2ce2GDPGTPase HRas/0.536
4xvrGNPGTPase HRas/0.535
3v4fGNPGTPase HRas/0.534
4g0nGNPGTPase HRas/0.534
4cidANPEH domain-containing protein 2/0.533
1g16GDPRas-related protein SEC4/0.532
4dsnGCPGTPase KRas/0.531
2rgeGNPGTPase HRas/0.530
3k8yGNPGTPase HRas/0.527
2mscGDPMHC class I alpha chain/0.524
4d0lGSPRas-related protein Rab-11A/0.523
2cl6CAGGTPase HRas/0.521
1d5cGDPGTPase (Rab6)/0.520
3k9lGNPGTPase HRas/0.520
3lbnGNPGTPase HRas/0.519
5difGNPGTP-binding nuclear protein Ran/0.518
1z2aGDPRas-related protein Rab-23/0.517
4dlvGNPGTPase HRas/0.516
4nyiGNPGTPase HRas/0.516
1q6t600Tyrosine-protein phosphatase non-receptor type 13.1.3.480.514
3i3sGNPGTPase HRas/0.514
3w3zGTPGTP-binding nuclear protein Ran/0.514
3oivGNPGTPase HRas/0.513
5b2zGNPGTPase HRas/0.513
5iqbGNPBifunctional AAC/APH2.3.10.513
3lbhGNPGTPase HRas/0.512
3x1zGNPRas-related protein Rap-1b/0.511
3rabGNPRas-related protein Rab-3A/0.510
3rs0GNPGTPase HRas/0.510
1z0aGDPRas-related protein Rab-2A/0.509
2c5lGTPGTPase HRas/0.509
3rs5GNPGTPase HRas/0.509
5jljGNPGTP-binding nuclear protein Ran/0.509
1n83CLRNuclear receptor ROR-alpha/0.508
3rs4GNPGTPase HRas/0.508
3vhxGTPADP-ribosylation factor 6/0.508
1dr3TAPDihydrofolate reductase1.5.1.30.507
3rslGNPGTPase HRas/0.506
1oixGDPRas-related protein Rab-11A/0.504
1xtrGNPGTP-binding protein Rheb/0.504
3cobADPKinesin heavy chain-like protein/0.504
3l8yGNPGTPase HRas/0.504
3oesGNPGTPase RhebL1/0.504
4dltGNPGTPase HRas/0.504
3k7mFAD6-hydroxy-L-nicotine oxidase/0.503
2xtnGTPGTPase IMAP family member 2/0.502
3bbpGTPRas-related protein Rab-6A/0.502
1dr2TAPDihydrofolate reductase1.5.1.30.501
1kphSAHCyclopropane mycolic acid synthase 12.1.1.790.500
3x1wGDPRas-related protein Rap-1b/0.500
4rkfGNPRas-related protein Rab-3/0.500
4wa7GDPGTPase KRas/0.500
1g17GNPRas-related protein SEC4/0.498
3d84NDPDihydrofolate reductase1.5.1.30.498
1d6w00RProthrombin3.4.21.50.497
1lfdGNPGTPase HRas/0.495
5iqgGDPBifunctional AAC/APH2.3.10.495
2izfBTNStreptavidin/0.494
4dlzGNPGTPase HRas/0.494
4ead0NPThymidine phosphorylase2.4.2.40.494
4js0GNPCell division control protein 42 homolog/0.494
1cxzGSPTransforming protein RhoA/0.493
1ky2GNPGTP-binding protein YPT7/0.493
3rs7GNPGTPase HRas/0.493
2rgcGNPGTPase HRas/0.492
4dlxGNPGTPase HRas/0.492
1a4rGNHCell division control protein 42 homolog/0.491
1z0dGDPRas-related protein Rab-5C/0.491
2rgbGNPGTPase HRas/0.491
3a6pGTPGTP-binding nuclear protein Ran/0.491
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.491
5il1SAMN6-adenosine-methyltransferase 70 kDa subunit/0.491
1t91GTPRas-related protein Rab-7a/0.490
2msdGNPMHC class I alpha chain/0.490
2ok8FADFerredoxin--NADP reductase, apicoplast/0.490
4px9ADPATP-dependent RNA helicase DDX3X3.6.4.130.490
5dhaGNPGTP-binding nuclear protein Ran/0.490
3lbiGNPGTPase HRas/0.489
3oiwGNPGTPase HRas/0.489
1e96GTPRas-related C3 botulinum toxin substrate 1/0.488
2xtzGSPGuanine nucleotide-binding protein alpha-1 subunit/0.488
4l9wGNPGTPase HRas/0.488
1n08ADPRiboflavin kinase2.7.1.260.487
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.487
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.487
4dlwGNPGTPase HRas/0.487
4o25GTPGTP-binding protein Rheb/0.487
2j0vGDPRac-like GTP-binding protein ARAC7/0.486
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.486
3ddw055Glycogen phosphorylase, liver form2.4.1.10.486
4k81GTPGTPase HRas/0.486
4l2xYL2Farnesyl pyrophosphate synthase2.5.1.100.486
4nyjGNPGTPase HRas/0.486
2ic5GNPRas-related C3 botulinum toxin substrate 3/0.485
4pkwGM6Lethal factor3.4.24.830.485
4xg1LLPDiaminopimelate decarboxylase/0.485
3oiuGNPGTPase HRas/0.484
3w8fNAD3-hydroxybutyrate dehydrogenase/0.484
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.483
4h5cYS4Farnesyl pyrophosphate synthase2.5.1.100.483
1kmqGNPTransforming protein RhoA/0.482
2gjlFMNNitronate monooxygenase1.13.12.160.482
4g01GDPRas-related protein RABF2b/0.482
4wbnGTPTubulin alpha-1B chain/0.482
8dfrNDPDihydrofolate reductase1.5.1.30.482
1pq944BOxysterols receptor LXR-beta/0.481
4qi5FADCellobiose dehydrogenase/0.481
1q6s214Tyrosine-protein phosphatase non-receptor type 13.1.3.480.480
3nga3NGCasein kinase II subunit alpha2.7.11.10.480
1dr5NAPDihydrofolate reductase1.5.1.30.479
2vprTDCTetracycline repressor protein class H/0.479
4demYS4Farnesyl pyrophosphate synthase2.5.1.100.479
4dlsGNPGTPase HRas/0.479
5eccNAPDehydrofolate reductase type I/0.479
1m78NDPDihydrofolate reductase1.5.1.30.478
1wdtGTPElongation factor G (EF-G-2)/0.478
1zc4GNPRas-related protein Ral-A/0.478
2p20PRXAcetyl-coenzyme A synthetase/0.478
3ea5GDPGTP-binding nuclear protein Ran/0.478
4itrGDPCell division control protein 42 homolog/0.478
1x1cSAHC-20 methyltransferase/0.477
1yzqGNPRas-related protein Rab-6A/0.477
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.477
2ffqGSPRas-related protein Rab-6B/0.477
2ydbNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.477
3zeiAWHO-acetylserine sulfhydrylase/0.477
4orkGDPBifunctional AAC/APH2.3.10.477
1pw1HELD-alanyl-D-alanine carboxypeptidase3.4.16.40.476
1tsxUMPThymidylate synthase/0.476
1zbdGTPRas-related protein Rab-3A/0.476
5iqdGNPBifunctional AAC/APH2.3.10.476
1db48INPhospholipase A2, membrane associated/0.475
1giaGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.475
1ypkCCRProthrombin3.4.21.50.475
3pcrGTPADP-ribosylation factor 6/0.475
3t88S0N1,4-dihydroxy-2-naphthoyl-CoA synthase/0.475
3wyfGTPGTP-binding nuclear protein/0.475
2l0xGDPGTP-binding protein Rheb/0.474
4mitGTPRho-related protein racC/0.474
1aztGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.473
1p4mADPRiboflavin kinase2.7.1.260.473
2x9dITCTetracycline repressor protein class D/0.473
3c15GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.473
4kwhNAPReductase homolog/0.473
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.473
1ia3TQ5Dihydrofolate reductase1.5.1.30.472
1opbRETRetinol-binding protein 2/0.472
2g8aUMPThymidylate synthase/0.472
2xw19NVSerum albumin/0.472
4a7b3W5Collagenase 33.4.240.472
4r1lADPPhenylacetate-coenzyme A ligase/0.472
1vzaUMPThymidylate synthase/0.471
1vzbUMPThymidylate synthase/0.471
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.471
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.471
4an4DUDPutative glycosyl transferase/0.471
4dsuGDPGTPase KRas/0.471
1ju9NADAlcohol dehydrogenase E chain1.1.1.10.470
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.470
2hamC33Vitamin D3 receptor/0.470
2r8oT5XTransketolase 1/0.470
2yg4FADPutrescine oxidase/0.470
4h5eYS4Farnesyl pyrophosphate synthase2.5.1.100.470
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.470
5iqiGNPBifunctional AAC/APH2.3.10.470
1n9mBTNStreptavidin/0.469
2bbwGP5Adenylate kinase 4, mitochondrial/0.469
2g89UMPThymidylate synthase/0.469
2p2mPRXAcetyl-coenzyme A synthetase/0.469
1ai9NDPDihydrofolate reductase1.5.1.30.468
1k5dGNPGTP-binding nuclear protein Ran/0.468
1njaDCMThymidylate synthase/0.468
1x1dSAHC-20 methyltransferase/0.468
2dxdANPNucleoside diphosphate kinase2.7.4.60.468
3kwn23ZCathepsin S3.4.22.270.468
3tnfGNPRas-related protein Rab-8A/0.468
1cs4GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.467
1qbqHFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.467
1qbqHFPProtein farnesyltransferase subunit beta2.5.1.580.467
1rx1NAPDihydrofolate reductase1.5.1.30.467
1wc3APCAdenylate cyclase/0.467
2g86UMPThymidylate synthase/0.467
2o7oDXTTetracycline repressor protein class D/0.467
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.467
2w06FRVCyclin-dependent kinase 22.7.11.220.467
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.467
3bk2U5PRibonuclease J/0.467
4d7mTDCTetracycline repressor protein class D/0.467
4gl4NAIAlcohol dehydrogenase class-3/0.467
4uyf73BBromodomain-containing protein 2/0.467
3fbuCOAAcetyltransferase, GNAT family/0.466
3kudGDPGTPase HRas/0.466
3th5GNPRas-related C3 botulinum toxin substrate 1/0.466
5il2SAHN6-adenosine-methyltransferase 70 kDa subunit/0.466
1hdoNAPFlavin reductase (NADPH)/0.465
1ibrGNPGTP-binding nuclear protein Ran/0.465
1jmiUMPThymidylate synthase/0.465
1z2nADPInositol-tetrakisphosphate 1-kinase2.7.1.1340.465
3i587NA2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase/0.465
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.465
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.465
1dgmADNAdenosine kinase2.7.1.200.464
1jmfUMPThymidylate synthase/0.464
1l2oADPMyosin heavy chain, striated muscle/0.464
1x1aSAMC-20 methyltransferase/0.464
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.464
2d4h5GPGuanylate-binding protein 1/0.464
2g8dUMPThymidylate synthase/0.464
2xlrFADPutative flavin-containing monooxygenase/0.464
3bgxMEFThymidylate synthase/0.464
3rhaFDAPutrescine oxidase/0.464
4fidGDPG protein alpha subunit, putative/0.464
4hdoGNPRas-related protein Rap-1b/0.464
4paoGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.464
1l2tATPUncharacterized ABC transporter ATP-binding protein MJ0796/0.463
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.463
2gcpGSPRho-related GTP-binding protein RhoC/0.463
2w71L23Biotin carboxylase6.3.4.140.463
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.463
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
4s1iPLPPyridoxal kinase, putative/0.463
1tsyUMPThymidylate synthase/0.462
2q9fC3SCholesterol 24-hydroxylase/0.462
3dds26BGlycogen phosphorylase, liver form2.4.1.10.462
4dxaGSPRas-related protein Rap-1b/0.462
4g1y0VOVitamin D3 receptor A/0.462
4o1mNADEnoyl-acyl carrier reductase/0.462
4o2lGTPGTP-binding protein Rheb/0.462
1am4GNPCell division control protein 42 homolog/0.461
1n4pCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.461
1rszDIHPurine nucleoside phosphorylase2.4.2.10.461
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.461
3mp3HGGHydroxymethylglutaryl-CoA lyase, mitochondrial4.1.3.40.461
4cmfPXGUncharacterized protein/0.461
4ii4BYC1,2-phenylacetyl-CoA epoxidase, subunit A1.14.13.1490.461
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.461
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.460
2bkuGTPGTP-binding nuclear protein Ran/0.460
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.460
2wlgSOPPolysialic acid O-acetyltransferase/0.460
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.460
2zetGTPRas-related protein Rab-27B/0.460
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.460
3f63GTXGlutathione transferase GST1-4/0.460
3kz1GSPTransforming protein RhoA/0.460
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.460
3pd4A3GThreonine--tRNA ligase6.1.1.30.460
3tjzGNPADP-ribosylation factor 1/0.460
4a81DXCMajor pollen allergen Bet v 1-A/0.460
4dsoGSPGTPase KRas/0.460
4ihjGTPTubulin alpha-1B chain/0.460
5jqgGTPTubulin alpha-1B chain/0.460
1s0xC3SNuclear receptor ROR-alpha/0.459
2c29NAPDihydroflavonol 4-reductase/0.459
2fj1CTCTetracycline repressor protein class D/0.459
2r8pT6FTransketolase 1/0.459
3ha3SAHHydroxymycolate synthase MmaA42.1.10.459
3umsGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.459
4b5oACOAlpha-tubulin N-acetyltransferase 1/0.459
4ceqQCHIntegrase/0.459
4dc0NDPPutative ketoacyl reductase1.3.10.459
4eb5PLPCysteine desulfurase IscS 2/0.459
4ehv0SJMitogen-activated protein kinase 14/0.459
4lhvGDPRas-related protein Rab-8A/0.459
4lzwTHMUridine phosphorylase/0.459
1rz0FADPhenol 2-hydroxylase component B/0.458
2ed4NAD4-hydroxyphenylacetate 3-monooxygenase reductase component1.5.1.360.458
2fhnBNIAvidin-related protein 4/5/0.458
2gilGTPRas-related protein Rab-6A/0.458
2xveFADPutative flavin-containing monooxygenase/0.458
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.458
3ngq1PSCCR4-NOT transcription complex subunit 6-like3.1.13.40.458
3t1tGDPProbable gliding protein mglA/0.458
3x2fNAIAdenosylhomocysteinase/0.458
4bfsZVSPantothenate kinase2.7.1.330.458
4cf23GMIntegrase/0.458
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
4jdcNADProbable pyrroline-5-carboxylate dehydrogenase RocA/0.458
1jnzFADAdenylylsulfate reductase, subunit A (AprA)/0.457
1n43BTNStreptavidin/0.457
1svwGTPProbable GTP-binding protein EngB/0.457
1u1d181Uridine phosphorylase2.4.2.30.457
2rtgBTNStreptavidin/0.457
3eg5GNPCell division control protein 42 homolog/0.457
3zoiM2WIsopenicillin N synthase1.21.3.10.457
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.457
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.457
5d3qGDPDynamin-13.6.5.50.457
5k7wSAHN6-adenosine-methyltransferase 70 kDa subunit/0.457
1fdrFADFerredoxin--NADP reductase1.18.1.20.456
1g6oADPCag alpha/0.456
1qo8FADFumarate reductase flavoprotein subunit/0.456
1rxhBNIStreptavidin/0.456
1wy7SAHUncharacterized protein/0.456
2qbs024Tyrosine-protein phosphatase non-receptor type 13.1.3.480.456
2r6gATPMaltose/maltodextrin import ATP-binding protein MalK/0.456
2xvfFADPutative flavin-containing monooxygenase/0.456
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.456
3b9lAZZSerum albumin/0.456
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
3fpkFADFerredoxin-NADP reductase/0.456
4dd8BATDisintegrin and metalloproteinase domain-containing protein 83.4.240.456
4gg50J3Hepatocyte growth factor receptor2.7.10.10.456
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.456
5bylGCPBifunctional AAC/APH2.3.10.456
5iqaGNPBifunctional AAC/APH2.3.10.456
1lwxAZDNucleoside diphosphate kinase, cytosolic2.7.4.60.455
1mmaADPMyosin-2 heavy chain/0.455
2geuCOKPantothenate kinase2.7.1.330.455
2ywlFADThioredoxin reductase related protein/0.455
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.455
4b722FBBeta-secretase 13.4.23.460.455
4weqNAPNAD-dependent dehydrogenase/0.455
1luqBTNStreptavidin/0.454
1wn3HXCPhenylacetic acid degradation protein PaaI/0.454
1z6lFADPolyamine oxidase FMS1/0.454
2dftADPShikimate kinase2.7.1.710.454
3w8eNAD3-hydroxybutyrate dehydrogenase/0.454
4dbs0HVAldo-keto reductase family 1 member C3/0.454
4emdC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.454
4k6fNAPPutative Acetoacetyl-CoA reductase/0.454
4q0kGA3Phytohormone-binding protein/0.454
4y0vGDPADP-ribosylation factor 1, putative/0.454
1bpjUMPThymidylate synthase/0.453
1njdUMPThymidylate synthase/0.453
1tj0FADBifunctional protein PutA1.5.5.20.453
1vg8GNPRas-related protein Rab-7a/0.453
2i0zFADNAD(FAD)-utilizing dehydrogenases/0.453
2p2bPRXAcetyl-coenzyme A synthetase/0.453
3e5hGNPRas-related protein Rab-28/0.453
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.453
4iarERM5-hydroxytryptamine receptor 1B/0.453
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.453
1t57FMNConserved protein/0.452
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
1z7yAA5Cysteine synthase 12.5.1.470.452
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.452
3t7vSAM3-methylornithine synthase/0.452
3v4aPK1Androgen receptor/0.452
3w2eNADNADH-cytochrome b5 reductase 31.6.2.20.452
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.452
4iteTEYVitamin D3 receptor/0.452
4jicFMNGTN Reductase/0.452
4kkyCAMCamphor 5-monooxygenase1.14.15.10.452
4l0qNADAlcohol dehydrogenase class-3/0.452
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.452
4xr9TMPCalS8/0.452
4y9lFADAcyl-CoA dehydrogenase family member 11/0.452
1c9k5GPBifunctional adenosylcobalamin biosynthesis protein CobU/0.451
1ikgREXD-alanyl-D-alanine carboxypeptidase3.4.16.40.451
1jqiFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial/0.451
1sriDMBStreptavidin/0.451
2fznFADBifunctional protein PutA1.5.5.20.451
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.451
2jb4A14Isopenicillin N synthase1.21.3.10.451
2vceU2FUDP-glycosyltransferase 72B1/0.451
2yg5FADPutrescine oxidase/0.451
3cinNADMyo-inositol-1-phosphate synthase-related protein/0.451
3m53SAHHistone-lysine N-methyltransferase SETD72.1.1.430.451
3phiNDPShikimate dehydrogenase (NADP(+))/0.451
3q9tFAYUncharacterized protein/0.451
3vt3VDXVitamin D3 receptor/0.451
3wagTYDGlycosyltransferase/0.451
4hx519VCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
5ch7MD1DMSO reductase family type II enzyme, molybdopterin subunit/0.451
1ma0NADAlcohol dehydrogenase class-31.1.1.10.450
1mvtDTMDihydrofolate reductase1.5.1.30.450
1qrrUPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.450
2a3iC0RMineralocorticoid receptor/0.450
2f3rG5PGuanylate kinase2.7.4.80.450
2re8GSUGlutamine--tRNA ligase6.1.1.180.450
2vq7FADPutative flavin-containing monooxygenase/0.450
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4eh8IRGMitogen-activated protein kinase 14/0.450
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.450
4g95OAGDihydrofolate reductase1.5.1.30.450
4gevCB3Thymidylate synthase/0.450
4klvKLVUncharacterized protein/0.450
1d3hA26Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.449
1j4jACOAcetyltransferase2.3.10.449
1nhkCMPNucleoside diphosphate kinase2.7.4.60.449
1pg3PRXAcetyl-coenzyme A synthetase/0.449
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.449
1z6tADPApoptotic protease-activating factor 1/0.449
2dw4FADLysine-specific histone demethylase 1A10.449
2eixFADNADH-cytochrome b5 reductase/0.449
2hu2NADC-terminal binding protein 1/0.449
2qblCAMCamphor 5-monooxygenase1.14.15.10.449
2xpuTDCTetracycline repressor protein class D/0.449
2yg6FADPutrescine oxidase/0.449
3dyh721Farnesyl pyrophosphate synthase/0.449
3oibFDAPutative acyl-CoA dehydrogenase/0.449
3pt9SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.449
3qlrNDPDihydrofolate reductase1.5.1.30.449
4bb3KKAIsopenicillin N synthase1.21.3.10.449
4buwF33Tankyrase-22.4.2.300.449
4eh7IRGMitogen-activated protein kinase 14/0.449
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.449
4rquNADAlcohol dehydrogenase class-P/0.449
1gilGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.448
1icqOPD12-oxophytodienoate reductase 11.3.1.420.448
1kbiFMNCytochrome b2, mitochondrial1.1.2.30.448
1mmkH4BPhenylalanine-4-hydroxylase1.14.16.10.448
1sreHABStreptavidin/0.448
1srfMTBStreptavidin/0.448
1tsvUMPThymidylate synthase/0.448
1txtCAAHMG-CoA synthase/0.448
1zdwFLVPrenyltransferase/0.448
2j9gANPBiotin carboxylase6.3.4.140.448
2oc9IMHPurine nucleoside phosphorylase2.4.2.10.448
2opmNI9Farnesyl pyrophosphate synthase2.5.1.100.448
2vssACOHydroxycinnamoyl-CoA hydratase-lyase4.1.2.410.448
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3aw9GDUNAD-dependent epimerase/dehydratase/0.448
3copADPGlycogen synthase2.4.1.210.448
3coxFADCholesterol oxidase1.1.3.60.448
3d7kD7KBenzaldehyde lyase/0.448
3imgBZ2Pantothenate synthetase6.3.2.10.448
3r7wGNPGTP-binding protein GTR2/0.448
3refGDPRho family GTPase/0.448
4imfSI3N-acetylneuraminate lyase/0.448
4irnFADAnaB/0.448
4lnbED5CaaX farnesyltransferase beta subunit Ram1/0.448
4ma628EAra h 8 allergen/0.448
4panGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.448
1i24UPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.447
1i2cUPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.447
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.447
2dr3ADPUPF0273 protein PH0284/0.447
2qbuSAHPrecorrin-2 methyltransferase/0.447
3e2sFADBifunctional protein PutA1.5.5.20.447
3g5qFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.447
3i7g732Collagenase 33.4.240.447
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.447
3wtkTH4Acetylcholine-binding protein/0.447
4gyy12VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.447
4kgkGTPUncharacterized protein/0.447
4krs1SXTankyrase-12.4.2.300.447
4l341VGTankyrase-22.4.2.300.447
4ms1381Gamma-aminobutyric acid type B receptor subunit 1/0.447
4nm9FADBifunctional protein PutA/0.447
4rheFMNFlavin prenyltransferase UbiX/0.447
4rx6ATPNitrogen regulatory PII-like protein/0.447
4ylgGDPADP-ribosylation factor 1, putative/0.447
1dhrNADDihydropteridine reductase1.5.1.340.446
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.446
1lcbTMPThymidylate synthase/0.446
1obnASVIsopenicillin N synthase1.21.3.10.446
1rkhVD2Vitamin D3 receptor/0.446
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.446
1vbiNADMalate/L-lactate dehydrogenase family protein/0.446
1w6hTITPlasmepsin-23.4.23.390.446
1x7hNDPPutative ketoacyl reductase1.3.10.446
2bryFAD[F-actin]-methionine sulfoxide oxidase MICAL11.14.130.446
2feuCAMCamphor 5-monooxygenase1.14.15.10.446
2pamTYDTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase5.3.2.30.446
3adaNADSubunit alpha of sarocosine oxidase/0.446
3syiFADSulfide-quinone reductase/0.446
4buxF35Tankyrase-22.4.2.300.446
4iijGTPTubulin alpha-1B chain/0.446
4o4lGTPTubulin alpha-1B chain/0.446
4u0mGTPCyclic GMP-AMP synthase/0.446
5di3GNPADP-ribosylation factor-like protein 3/0.446
5dibNADBetaine-aldehyde dehydrogenase/0.446
1jscTPPAcetolactate synthase catalytic subunit, mitochondrial2.2.1.60.445
1m9tINENitric oxide synthase, inducible1.14.13.390.445
1rd4L08Integrin alpha-L/0.445
1uvsI11Prothrombin3.4.21.50.445
1vcfFMNIsopentenyl-diphosphate delta-isomerase/0.445
1youPFDCollagenase 33.4.240.445
1zg32HIIsoflavone 4'-O-methyltransferase/0.445
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.445
2b8v3BNBeta-secretase 13.4.23.460.445
2d1nFA4Collagenase 33.4.240.445
2m56CAMCamphor 5-monooxygenase1.14.15.10.445
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.445
3a783EVVitamin D3 receptor/0.445
3clsFADElectron transfer flavoprotein subunit alpha/0.445
3e23SAMUncharacterized protein/0.445
3gdpFAD(R)-mandelonitrile lyase 24.1.2.100.445
3ha7B32Hydroxymycolate synthase MmaA42.1.10.445
3ijdC2FMethylenetetrahydrofolate reductase/0.445
3k7tFAD6-hydroxy-L-nicotine oxidase/0.445
3ldoANP78 kDa glucose-regulated protein/0.445
3ou2SAHSAM-dependent methyltransferase/0.445
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.445
3u9eCOALmo1369 protein/0.445
4b2gV1NUncharacterized protein/0.445
4h2w5GPAmino acid--[acyl-carrier-protein] ligase 16.2.1.n20.445
4i421HA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.445
4imgNGFN-acetylneuraminate lyase/0.445
1booSAHModification methylase PvuII2.1.1.1130.444
1bp6UMPThymidylate synthase/0.444
1e4gATPCell division protein FtsA/0.444
1jjeBYSBeta-lactamase/0.444
1kp2ATPArgininosuccinate synthase6.3.4.50.444
1l2sSTCBeta-lactamase3.5.2.60.444
1t5bFMNFMN-dependent NADH-azoreductase/0.444
1y3aGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.444
1yrcCAMCamphor 5-monooxygenase1.14.15.10.444
2bfrADP[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.444
2c2aADPSensor histidine kinase/0.444
2gvdFKPAdenylate cyclase type 2/0.444
2gvdFKPAdenylate cyclase type 5/0.444
2ozrGG1Collagenase 33.4.240.444
2wlfACOPolysialic acid O-acetyltransferase/0.444
3e5aVX6Aurora kinase A2.7.11.10.444
3h3t16HCollagen type IV alpha-3-binding protein/0.444
3hy7097A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.444
3i8p8403-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.444
3qge26FGenome polyprotein2.7.7.480.444
3raiX85Cyclin-dependent kinase 22.7.11.220.444
3up3XCAaceDAF-12/0.444
3w8wFADPutative FAD-dependent oxygenase EncM/0.444
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.444
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.444
4blsAPCNTPase P4/0.444
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.444
4p13FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.444
4qzuRTLRetinol-binding protein 2/0.444
4tm0NAPKtzI/0.444
4ttbFMNIodotyrosine deiodinase 1/0.444
5burATP2-succinylbenzoate--CoA ligase/0.444
5fm7ADPRuvB-like helicase/0.444
5kf2ACOPredicted acetyltransferase/0.444
1dfoFFOSerine hydroxymethyltransferase2.1.2.10.443
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.443
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1n4hREANuclear receptor ROR-beta/0.443
1njeDCMThymidylate synthase/0.443
1orkATCTetracycline repressor protein class D/0.443
1v35NAIEnoyl-ACP reductase/0.443
2b56UTPRNA editing complex protein MP57/0.443
2fonFADAcyl-coenzyme A oxidase/0.443
2gn4UD1UDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.443
2o12FMNChorismate synthase/0.443
2y67N21UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.443
2zpaADPtRNA(Met) cytidine acetyltransferase TmcA/0.443
3akm11DFatty acid-binding protein, intestinal/0.443
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.443
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.443
3gwdNAPCyclohexanone monooxygenase/0.443
3ixp834Ecdysone receptor/0.443
3l63CAMCamphor 5-monooxygenase1.14.15.10.443
3zc5W9ZHepatocyte growth factor receptor2.7.10.10.443
4b3aTACTetracycline repressor protein class D/0.443
4bueJQFTankyrase-22.4.2.300.443
4g67SAHUncharacterized ACR, COG1565 superfamily/0.443
4gojGNPADP-ribosylation factor-like protein 3/0.443
4jauADPSensor histidine kinase/0.443
4ly91YYGlucokinase regulatory protein/0.443
4oe4NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.880.443
4ubvCOASteroid 3-ketoacyl-CoA thiolase/0.443
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.443
1a2bGSPTransforming protein RhoA/0.442
1be4PCGNucleoside diphosphate kinase A 22.7.4.60.442
1bp0UMPThymidylate synthase/0.442
1drhNAPDihydrofolate reductase1.5.1.30.442
1kr2TADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.442
1p8dCO1Oxysterols receptor LXR-beta/0.442
1piwNAPNADP-dependent alcohol dehydrogenase 61.1.1.20.442
1pqc444Oxysterols receptor LXR-beta/0.442
1qy5NECEndoplasmin/0.442
1rjdSAMLeucine carboxyl methyltransferase 12.1.1.2330.442
1rx8FOLDihydrofolate reductase1.5.1.30.442
1swdBTNStreptavidin/0.442
1wklATPNucleoside diphosphate kinase/0.442
2gvdGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.442
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.442
2q1tNADPutative nucleotide sugar epimerase/ dehydratase/0.442
2vbpVB1Isopenicillin N synthase1.21.3.10.442
3b9oFMNAlkane monoxygenase/0.442
3cbpSFGHistone-lysine N-methyltransferase SETD72.1.1.430.442
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3f1kNAPUncharacterized oxidoreductase YciK10.442
3fpdSAHHistone-lysine N-methyltransferase EHMT1/0.442
3fwgCAMCamphor 5-monooxygenase1.14.15.10.442
3mykANPMyosin-2 heavy chain/0.442
3nxxNDPDihydrofolate reductase1.5.1.30.442
3pqbVGPPutative oxidoreductase/0.442
3rj9NADAlcohol dehydrogenase1.1.1.10.442
3vrwYS5Vitamin D3 receptor/0.442
3vt7VDXVitamin D3 receptor/0.442
3zbzOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.442
4bfyZVYPantothenate kinase2.7.1.330.442
4ceoG0TIntegrase/0.442
4glx0XSDNA ligase6.5.1.20.442
4p9dTMPDeoxycytidylate deaminase/0.442
5hs1VORLanosterol 14-alpha demethylase/0.442
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.441
1efvFADElectron transfer flavoprotein subunit alpha, mitochondrial/0.441
1ow3GDPTransforming protein RhoA/0.441
1swpBTQStreptavidin/0.441
1szfFMNCytochrome b2, mitochondrial1.1.2.30.441
1t2cNAIL-lactate dehydrogenase1.1.1.270.441
1tkaN3TTransketolase 12.2.1.10.441
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.441
2qd5CHDFerrochelatase, mitochondrial4.99.1.10.441
2yig5ELCollagenase 33.4.240.441
2yy7NADL-threonine dehydrogenase/0.441
2zryFNRIsopentenyl-diphosphate delta-isomerase/0.441
3aosJH2Hemolymph juvenile hormone binding protein/0.441
3cosNADAlcohol dehydrogenase 41.1.1.10.441
3golXNDGenome polyprotein2.7.7.480.441
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.441
3mj4URMUDP-galactopyranose mutase/0.441
3ojwFADNADPH--cytochrome P450 reductase/0.441
3qv1NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic1.2.1.130.441
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4iwyADPRibosomal protein S6--L-glutamate ligase/0.441
4obwSAM2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial/0.441
5e8jSAHmRNA cap guanine-N7 methyltransferase2.1.1.560.441
5ftfADPTPR domain protein/0.441
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.441
5jjrSAHGenome polyprotein/0.441
1ay0TPPTransketolase 12.2.1.10.440
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.440
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
1o01NADAldehyde dehydrogenase, mitochondrial1.2.1.30.440
1oc1ASVIsopenicillin N synthase1.21.3.10.440
1s1cGNPTransforming protein RhoA/0.440
1wc1TATAdenylate cyclase/0.440
1wwkNAD307aa long hypothetical phosphoglycerate dehydrogenase/0.440
2a4nCOAAac(6')-Ii protein/0.440
2cduFADNADH oxidase/0.440
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2po7CHDFerrochelatase, mitochondrial4.99.1.10.440
2v8pCDP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.440
2vf0F89Thymidylate synthase/0.440
2y3fBTNStreptavidin/0.440
2yeiXQIHeat shock protein HSP 90-alpha/0.440
3atzFMNProstaglandin F2a synthase/0.440
3c16GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.440
3fp0FP015-O-acetyltransferase/0.440
3ihkTPPUncharacterized protein/0.440
3o3jBB4Peptide deformylase 1B, chloroplastic/mitochondrial3.5.1.880.440
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.440
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4cdmFO1Deoxyribodipyrimidine photolyase/0.440
4ffrATPUncharacterized protein/0.440
4ihl1F514-3-3 protein zeta/delta/0.440
4k9yK9YFocal adhesion kinase 12.7.10.20.440
4y7cFMNNADPH--cytochrome P450 reductase/0.440
4yddMD1DMSO reductase family type II enzyme, molybdopterin subunit/0.440