sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2bd0 | BIO | Sepiapterin reductase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2bd0 | BIO | Sepiapterin reductase | / | 1.000 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.543 | |
| 2vz0 | D64 | Pteridine reductase | / | 0.536 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.521 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.518 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.509 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.509 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.508 | |
| 4xcz | T3Q | Qdtf | / | 0.506 | |
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.505 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.504 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.503 | |
| 3rgz | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.502 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.500 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.500 | |
| 4yfy | 0FX | VioF | / | 0.500 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.498 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.497 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.496 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.494 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.494 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.494 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.493 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.493 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.493 | |
| 1isg | AGS | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.491 | |
| 2iu8 | UD1 | UDP-3-O-acylglucosamine N-acyltransferase | 2.3.1 | 0.490 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.490 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.490 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 4cb6 | 29R | Polymerase basic protein 2 | / | 0.488 | |
| 4a33 | PS8 | Glycylpeptide N-tetradecanoyltransferase | / | 0.487 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.486 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.486 | |
| 4nce | MGT | Polymerase basic protein 2 | / | 0.486 | |
| 1uk1 | FRQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.485 | |
| 3ele | PLP | Aminotransferase | / | 0.485 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.484 | |
| 3ai0 | PNW | Beta-glucosidase | / | 0.484 | |
| 4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.484 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.483 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.483 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.482 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.482 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.482 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.482 | |
| 5fmm | MGT | Polymerase basic protein 2 | / | 0.482 | |
| 3bmq | AX5 | Pteridine reductase | / | 0.481 | |
| 4nv1 | 4TG | Formyl transferase | / | 0.481 | |
| 5a4w | QCT | Glutathione S-transferase F2 | 2.5.1.18 | 0.481 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.480 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.480 | |
| 2c2b | SAM | Threonine synthase 1, chloroplastic | 4.2.3.1 | 0.480 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.480 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.480 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.480 | |
| 1rxj | BNI | Streptavidin | / | 0.479 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.479 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.479 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.479 | |
| 3jq8 | DX3 | Pteridine reductase, putative | / | 0.479 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.479 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.479 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.479 | |
| 1icq | OPD | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.478 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.478 | |
| 3l3l | L3L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.478 | |
| 3lzz | GDP | Uncharacterized protein | / | 0.478 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.477 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.477 | |
| 3dr4 | G4M | GDP-perosamine synthase | / | 0.477 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.477 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.476 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.476 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.476 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.476 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.476 | |
| 3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.476 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 4nv1 | TYD | Formyl transferase | / | 0.476 | |
| 4s1i | PLP | Pyridoxal kinase, putative | / | 0.476 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.475 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.475 | |
| 2rdn | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.475 | |
| 3ugr | IMN | Aldo-keto reductase family 1 member C3 | / | 0.475 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.475 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.475 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.474 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.474 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.474 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.474 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.474 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.473 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.473 | |
| 2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.473 | |
| 3irh | DTP | HD domain protein | / | 0.473 | |
| 4jq2 | SUZ | Aldo-keto reductase family 1 member C2 | / | 0.473 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.473 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.472 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.472 | |
| 4g1n | NZT | Pyruvate kinase PKM | 2.7.1.40 | 0.472 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.472 | |
| 3ikt | NAD | Redox-sensing transcriptional repressor Rex | / | 0.471 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.471 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.471 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.471 | |
| 1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.470 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.470 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.470 | |
| 2ixk | TDO | dTDP-4-dehydrorhamnose 3,5-epimerase | 5.1.3.13 | 0.470 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.470 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.470 | |
| 3rqw | ACH | Gamma-aminobutyric-acid receptor subunit beta-1 | / | 0.470 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.470 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.470 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.470 | |
| 4kfq | KFQ | Glutamate receptor ionotropic, NMDA 1 | / | 0.470 | |
| 4phl | PIL | Phosphodiesterase | / | 0.470 | |
| 1q6n | P90 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.469 | |
| 2jgb | MGT | Eukaryotic translation initiation factor 4E type 2 | / | 0.469 | |
| 2x9v | TMQ | Pteridine reductase | / | 0.469 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.469 | |
| 3dr7 | GPD | GDP-perosamine synthase | / | 0.469 | |
| 3e4a | QIX | Insulin-degrading enzyme | 3.4.24.56 | 0.469 | |
| 3zj6 | VM2 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.469 | |
| 4cb7 | 41G | Polymerase basic protein 2 | / | 0.469 | |
| 4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.469 | |
| 4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.469 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.469 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.469 | |
| 1amo | FMN | NADPH--cytochrome P450 reductase | / | 0.468 | |
| 1nsg | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.468 | |
| 1nsg | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.468 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.468 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.468 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.468 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.468 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.468 | |
| 4b2g | V1N | Uncharacterized protein | / | 0.468 | |
| 4hcy | 0YN | Transketolase | / | 0.468 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.468 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.468 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.468 | |
| 1fml | RTL | Retinol dehydratase | / | 0.467 | |
| 1fwy | UD1 | Bifunctional protein GlmU | / | 0.467 | |
| 1qgy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.467 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.467 | |
| 2pb1 | NFG | Glucan 1,3-beta-glucosidase | / | 0.467 | |
| 4q7f | 3D1 | Uncharacterized protein | / | 0.467 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.467 | |
| 1uhj | CZB | Aequorin-2 | / | 0.466 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.466 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.466 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.466 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.466 | |
| 4kmz | FOL | Folate receptor beta | / | 0.466 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.465 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.465 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.465 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.465 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 4cb4 | MGT | Polymerase basic protein 2 | / | 0.465 | |
| 1que | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.464 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.464 | |
| 2vqz | MGT | Polymerase basic protein 2 | / | 0.464 | |
| 2vrj | NCW | Beta-glucosidase A | 3.2.1.21 | 0.464 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.464 | |
| 3gf4 | U5P | UDP-galactopyranose mutase | 5.4.99.9 | 0.464 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.464 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.464 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.464 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.464 | |
| 1w87 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.463 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.463 | |
| 1xmm | M7G | m7GpppX diphosphatase | 3.6.1.59 | 0.463 | |
| 1zz1 | SHH | Histone deacetylase-like amidohydrolase | 3.5.1 | 0.463 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.463 | |
| 3h7r | NAP | Aldo-keto reductase family 4 member C8 | / | 0.463 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.463 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.463 | |
| 4kn1 | 04J | Folate receptor beta | / | 0.463 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.462 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.462 | |
| 1n5v | NOM | ActVA 6 protein | / | 0.462 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.462 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.462 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.462 | |
| 3szf | DCQ | Sulfide-quinone reductase | / | 0.462 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.462 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 4jt9 | 1NS | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.462 | |
| 4lcw | 1VY | Major histocompatibility complex class I-related gene protein | / | 0.462 | |
| 4nqg | CZH | Mitrocomin | / | 0.462 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.461 | |
| 1pr4 | MTP | Purine nucleoside phosphorylase DeoD-type | / | 0.461 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.461 | |
| 1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.461 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.461 | |
| 2ggb | U17 | Methionine aminopeptidase | / | 0.461 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.461 | |
| 3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.461 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.461 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.461 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.461 | |
| 3znr | NU9 | Histone deacetylase 7 | 3.5.1.98 | 0.461 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.461 | |
| 4gv7 | MEW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.461 | |
| 4zzj | CNA | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.461 | |
| 5bn3 | ADP | V-type ATP synthase alpha chain | / | 0.461 | |
| 5bn3 | ADP | NEQ263 | / | 0.461 | |
| 5bv3 | M7G | m7GpppX diphosphatase | 3.6.1.59 | 0.461 | |
| 6std | MS2 | Scytalone dehydratase | 4.2.1.94 | 0.461 | |
| 1by5 | GLY_GLY_GLY_AHO_AHO_AHO_FE | Ferrichrome-iron receptor | / | 0.460 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.460 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.460 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.460 | |
| 3cui | X4S | Exoglucanase/xylanase | 3.2.1.91 | 0.460 | |
| 3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.460 | |
| 3gx9 | TXD | Morphinone reductase | / | 0.460 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3r7m | SUZ | Aldo-keto reductase family 1 member C3 | / | 0.460 | |
| 4bvh | OCZ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.460 | |
| 4fa3 | 0SL | Aldo-keto reductase family 1 member C3 | / | 0.460 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.460 | |
| 5cxv | 0HK | Muscarinic acetylcholine receptor M1 | / | 0.460 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.459 | |
| 2ejz | SAH | Diphthine synthase | / | 0.459 | |
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.459 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.459 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.459 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.459 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.459 | |
| 4ybn | FAD | Flavin-nucleotide-binding protein | / | 0.459 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.458 | |
| 1rvv | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.458 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.458 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.458 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 3g5i | DNB | Pyrimidine-specific ribonucleoside hydrolase RihA | / | 0.458 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.458 | |
| 3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.458 | |
| 3jq7 | DX2 | Pteridine reductase, putative | / | 0.458 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.458 | |
| 1dp2 | LPB | Thiosulfate sulfurtransferase | / | 0.457 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.457 | |
| 1z4i | UMP | 5'(3')-deoxyribonucleotidase, mitochondrial | 3.1.3 | 0.457 | |
| 2o6h | INI | 6,7-dimethyl-8-ribityllumazine synthase 1 | 2.5.1.78 | 0.457 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.457 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.457 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.457 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.457 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.457 | |
| 4paa | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.457 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.456 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.456 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.456 | |
| 3cv6 | HXS | Aldo-keto reductase family 1 member C21 | / | 0.456 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.456 | |
| 4e0i | FAD | Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 1.8.3.2 | 0.456 | |
| 4gr9 | 372 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.456 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.456 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.455 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.455 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.455 | |
| 2bfa | CB3 | Pteridine reductase 1 | 1.5.1.33 | 0.455 | |
| 2gg2 | U12 | Methionine aminopeptidase | / | 0.455 | |
| 2gms | P0P | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.455 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 3c1o | NAP | Eugenol synthase | / | 0.455 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.455 | |
| 3jq6 | DX1 | Pteridine reductase, putative | / | 0.455 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.455 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.455 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.455 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.455 | |
| 3s8p | SAM | Histone-lysine N-methyltransferase KMT5B | 2.1.1.43 | 0.455 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.455 | |
| 3zo7 | K6H | Muconolactone Delta-isomerase | / | 0.455 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.455 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 4to4 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.455 | |
| 1dls | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1kyy | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.454 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 1rpw | DID | HTH-type transcriptional regulator QacR | / | 0.454 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.454 | |
| 2g7y | MO9 | Cathepsin S | 3.4.22.27 | 0.454 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.454 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.454 | |
| 2mji | KTR | Fatty acid-binding protein, intestinal | / | 0.454 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.454 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.454 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 4b64 | NAP | L-ornithine N(5)-monooxygenase | / | 0.454 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.454 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 4e32 | DWN | Methyltransferase | / | 0.454 | |
| 4n1f | CZH | Obelin | / | 0.454 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.453 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 2rd2 | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.453 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.453 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.453 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3fvu | IAC | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.453 | |
| 3l3m | A92 | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.453 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.453 | |
| 4da5 | 0H7 | Choline kinase alpha | 2.7.1.32 | 0.453 | |
| 4dyp | 0MS | Nucleoprotein | / | 0.453 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.453 | |
| 4xp4 | COC | Sodium-dependent dopamine transporter | / | 0.453 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.452 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.452 | |
| 1thz | 326 | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.452 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.452 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.452 | |
| 2poq | ISD | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 1.3.1.20 | 0.452 | |
| 2rc6 | FAD | Ferredoxin--NADP reductase | / | 0.452 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.452 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.452 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.452 | |
| 3r9f | GSU | MccE protein | / | 0.452 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.452 | |
| 4cb5 | 93G | Polymerase basic protein 2 | / | 0.452 | |
| 4iks | TFD | Methionine aminopeptidase 1 | / | 0.452 | |
| 4itx | IN5 | Cystathionine beta-lyase MetC | 4.4.1.8 | 0.452 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 1h42 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.451 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.451 | |
| 1pj7 | FFO | Dimethylglycine oxidase | 1.5.3.10 | 0.451 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.451 | |
| 1xzq | FON | tRNA modification GTPase MnmE | 3.6.5 | 0.451 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.451 | |
| 2po3 | T4K | 4-dehydrase | / | 0.451 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.451 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.451 | |
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 0.451 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.451 | |
| 3pkd | Y10 | Methionine aminopeptidase 2 | / | 0.451 | |
| 3r6i | JMS | Aldo-keto reductase family 1 member C3 | / | 0.451 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.451 | |
| 3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 0.451 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.450 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.450 | |
| 1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.450 | |
| 1xq0 | 4TR | Carbonic anhydrase 2 | 4.2.1.1 | 0.450 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.450 | |
| 2cle | F6F | Tryptophan synthase alpha chain | / | 0.450 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2gg0 | U11 | Methionine aminopeptidase | / | 0.450 | |
| 2gg3 | U13 | Methionine aminopeptidase | / | 0.450 | |
| 2hzq | STR | Apolipoprotein D | / | 0.450 | |
| 2r86 | ATP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase | / | 0.450 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 3dla | NXX | Glutamine-dependent NAD(+) synthetase | 6.3.5.1 | 0.450 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.450 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 3occ | DIH | Purine nucleoside phosphorylase DeoD-type | / | 0.450 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.450 | |
| 3vil | SA0 | Beta-glucosidase | / | 0.450 | |
| 3w4k | 3LD | D-amino-acid oxidase | 1.4.3.3 | 0.450 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.450 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.450 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.450 | |
| 1b2r | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.449 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.449 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1s2c | FLF | Aldo-keto reductase family 1 member C3 | / | 0.449 | |
| 1tfz | 869 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.449 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.449 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.449 | |
| 1xnz | FCD | Methionine aminopeptidase | / | 0.449 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.449 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.449 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.449 | |
| 2zi6 | 3D1 | Deoxycytidine kinase | 2.7.1.74 | 0.449 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 3arv | SAU | Chitinase A | / | 0.449 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.449 | |
| 3i9j | NFD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase | 3.2.2.6 | 0.449 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 4a7z | AY9 | Aldos-2-ulose dehydratase | / | 0.449 | |
| 4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.449 | |
| 4bvh | AR6 | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.449 | |
| 4da7 | AC2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.449 | |
| 4flk | Y10 | Methionine aminopeptidase 1 | / | 0.449 | |
| 4gki | 0JN | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.449 | |
| 4hld | 16T | Thymidylate kinase | / | 0.449 | |
| 5dp2 | NAP | CurF | / | 0.449 | |
| 1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.448 | |
| 1gjr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.448 | |
| 1jdz | FMB | Purine nucleoside phosphorylase | / | 0.448 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 1uhh | CZP | Aequorin-2 | / | 0.448 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.448 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.448 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.448 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.448 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.448 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.448 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.448 | |
| 3w5u | FAD | Ferredoxin | / | 0.448 | |
| 3wi2 | P98 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 4gab | FID | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.448 | |
| 4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.448 | |
| 1acj | THA | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.447 | |
| 1k4m | NAD | Nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.447 | |
| 1map | KET | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.447 | |
| 1sm4 | FAD | Ferredoxin--NADP reductase | / | 0.447 | |
| 1t47 | NTD | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.447 | |
| 2cmf | F11 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2f99 | AKV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.447 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2ipj | FFA | Aldo-keto reductase family 1 member C2 | / | 0.447 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.447 | |
| 2rku | R78 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.447 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.447 | |
| 3iu9 | T07 | Methionine aminopeptidase 2 | / | 0.447 | |
| 3jt3 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.447 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.447 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.447 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4bek | XK0 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.447 | |
| 4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.447 | |
| 1bx0 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.446 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.446 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.446 | |
| 1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1gt5 | BZQ | Odorant-binding protein | / | 0.446 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.446 | |
| 1qru | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.446 | |
| 1xid | ASC | Xylose isomerase | 5.3.1.5 | 0.446 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.446 | |
| 2vqq | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.446 | |
| 2y67 | N21 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.446 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.446 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 3zov | WZV | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 4da6 | GA2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.446 | |
| 4dk7 | 0KS | Oxysterols receptor LXR-beta | / | 0.446 | |
| 4u15 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.446 | |
| 1oj4 | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.445 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.445 | |
| 1swg | BTN | Streptavidin | / | 0.445 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.445 | |
| 1vkg | CRI | Histone deacetylase 8 | 3.5.1.98 | 0.445 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.445 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.445 | |
| 2g6p | HM2 | Methionine aminopeptidase 1 | / | 0.445 | |
| 2qx7 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.445 | |
| 2wea | PP6 | Penicillopepsin-1 | 3.4.23.20 | 0.445 | |
| 2xeg | CI9 | Glutamate carboxypeptidase 2 | 3.4.17.21 | 0.445 | |
| 3af4 | GCP | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.445 | |
| 3p9t | TCL | Repressor | / | 0.445 | |
| 3v2u | ATP | Protein GAL3 | / | 0.445 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.445 | |
| 4j7g | TRH | PCZA361.3 | / | 0.445 | |
| 4j7h | TRH | PCZA361.3 | / | 0.445 | |
| 4kn2 | LYA | Folate receptor beta | / | 0.445 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.445 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.445 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.444 | |
| 1gm9 | SOX | Penicillin G acylase | 3.5.1.11 | 0.444 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1ivr | CBA | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.444 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.444 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.444 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.444 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.444 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.444 | |
| 2wnb | C5P | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 | 2.4.99.4 | 0.444 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.444 | |
| 4a16 | H34 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 4e2y | JHZ | Methyltransferase | / | 0.444 | |
| 4es5 | MGT | Polymerase basic protein 2 | / | 0.444 | |
| 4i10 | 1BS | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.444 | |
| 4k4e | K4E | Tankyrase-1 | 2.4.2.30 | 0.444 | |
| 4mz7 | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.444 | |
| 4x3u | SVR | Chromobox protein homolog 7 | / | 0.444 | |
| 4xd1 | T3Q | Qdtf | / | 0.444 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.444 | |
| 1el4 | CTZ | Obelin | / | 0.443 | |
| 1go2 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.443 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.443 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.443 | |
| 1pr6 | XYA | Purine nucleoside phosphorylase DeoD-type | / | 0.443 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.443 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.443 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.443 | |
| 2bpo | FAD | NADPH--cytochrome P450 reductase | / | 0.443 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.443 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.443 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.443 | |
| 2j7c | IDE | Beta-glucosidase A | 3.2.1.21 | 0.443 | |
| 2pnu | ENM | Androgen receptor | / | 0.443 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.443 | |
| 2vq3 | NAP | Metalloreductase STEAP3 | / | 0.443 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2y1x | 845 | Histone-arginine methyltransferase CARM1 | / | 0.443 | |
| 3cas | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3inr | GDU | UDP-galactopyranose mutase | 5.4.99.9 | 0.443 | |
| 3ocx | 2AM | Lipoprotein E | / | 0.443 | |
| 3q99 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.443 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.443 | |
| 3zg6 | APR | NAD-dependent protein deacetylase sirtuin-6 | 3.5.1 | 0.443 | |
| 4c5o | FAD | Putative monooxygenase | / | 0.443 | |
| 4hyf | 1AK | Tankyrase-2 | 2.4.2.30 | 0.443 | |
| 3ny8 | JRZ | Beta-2 adrenergic receptor | / | 0.443 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.442 | |
| 1ja0 | FMN | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 1jra | FAD | FAD-linked sulfhydryl oxidase ERV2 | 1.8.3.2 | 0.442 | |
| 1qv0 | CZH | Obelin | / | 0.442 | |
| 1s36 | CEI | Obelin | / | 0.442 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.442 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.442 | |
| 2bkt | RPF | Renin | 3.4.23.15 | 0.442 | |
| 2evc | FC3 | Methionine aminopeptidase | / | 0.442 | |
| 2idv | M7G | Eukaryotic translation initiation factor 4E-1 | / | 0.442 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.442 | |
| 2vt4 | P32 | Beta-1 adrenergic receptor | / | 0.442 | |
| 2xej | OKD | Glutamate carboxypeptidase 2 | 3.4.17.21 | 0.442 | |
| 2y05 | RAL | Prostaglandin reductase 1 | / | 0.442 | |
| 3jt4 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.442 | |
| 3o9l | LPN | Renin | 3.4.23.15 | 0.442 | |
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.442 | |
| 4br3 | U85 | Choline kinase alpha | 2.7.1.32 | 0.442 | |
| 4dan | 2FA | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.442 | |
| 4f1q | 0RZ | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.442 | |
| 4hfp | 15U | Prothrombin | 3.4.21.5 | 0.442 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.442 | |
| 5agk | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 2y04 | 68H | Beta-1 adrenergic receptor | / | 0.442 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.441 | |
| 1e64 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.441 | |
| 1isj | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.441 | |
| 1jf2 | CZH | Obelin | / | 0.441 | |
| 1lvu | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 1o1t | 2NH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 1odj | GMP | Purine nucleoside phosphorylase | / | 0.441 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.441 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.441 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.441 | |
| 1zdw | FLV | Prenyltransferase | / | 0.441 | |
| 2f59 | INI | 6,7-dimethyl-8-ribityllumazine synthase 1 | / | 0.441 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.441 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.441 | |
| 2gg9 | U16 | Methionine aminopeptidase | / | 0.441 | |
| 2qjp | ANJ | Cytochrome b | / | 0.441 | |
| 2re8 | GSU | Glutamine--tRNA ligase | 6.1.1.18 | 0.441 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.441 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.441 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.441 | |
| 3f6s | FMN | Flavodoxin | / | 0.441 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
| 3i0o | SMI | Spectinomycin phosphotransferase | / | 0.441 | |
| 3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.441 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 4bfq | 083 | Soluble acetylcholine receptor | / | 0.441 | |
| 4fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.441 | |
| 4fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.441 | |
| 4hsh | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.441 | |
| 4mm7 | 29J | Na(+):neurotransmitter symporter (Snf family) | / | 0.441 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.441 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.441 | |
| 5dsg | 0HK | Muscarinic acetylcholine receptor M4 | / | 0.441 | |
| 5a8e | XTK | Beta-1 adrenergic receptor | / | 0.441 | |
| 1dpm | EBP | Parathion hydrolase | 3.1.8.1 | 0.440 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1qin | GIP | Lactoylglutathione lyase | 4.4.1.5 | 0.440 | |
| 1s1p | NAP | Aldo-keto reductase family 1 member C3 | / | 0.440 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1xi2 | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.440 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.440 | |
| 2nq7 | HM5 | Methionine aminopeptidase 1 | / | 0.440 | |
| 2nvd | ITB | Aldose reductase | 1.1.1.21 | 0.440 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2wm3 | NFL | NmrA-like family domain-containing protein 1 | / | 0.440 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.440 | |
| 3fpk | FAD | Ferredoxin-NADP reductase | / | 0.440 | |
| 3frk | TQP | QdtB | / | 0.440 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.440 | |
| 3ipq | 965 | Oxysterols receptor LXR-alpha | / | 0.440 | |
| 3kaq | FMN | Flavodoxin | / | 0.440 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.440 | |
| 3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.440 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.440 | |
| 4af6 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.440 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4gtr | 7TR | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 2ycx | P32 | Beta-1 adrenergic receptor | / | 0.440 | |
| 4daj | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.440 |