sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1ols | TDP | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1ols | TDP | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 1.000 | |
| 2i0y | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.513 | |
| 3zhs | TD6 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.508 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.506 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.502 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.502 | |
| 5aqz | SGV | Heat shock 70 kDa protein 1A | / | 0.502 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.501 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.500 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.499 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.499 | |
| 3zhv | TDW | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.499 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.498 | |
| 1lb9 | DNQ | Glutamate receptor 2 | / | 0.497 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.494 | |
| 4tle | AGS | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.493 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.492 | |
| 1v11 | TDP | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.491 | |
| 4c7x | TPP | Transketolase | / | 0.490 | |
| 2ihv | TPP | N(2)-(2-carboxyethyl)arginine synthase | / | 0.489 | |
| 4zz7 | NAD | Methylmalonate-semialdehyde dehydrogenase | / | 0.488 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.486 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.483 | |
| 4isu | IKM | Glutamate receptor 2 | / | 0.483 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.482 | |
| 3h03 | UBP | Glutamate receptor 2 | / | 0.482 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.481 | |
| 4h6p | FMN | Chromate reductase | / | 0.481 | |
| 1qxo | FMN | Chorismate synthase | / | 0.480 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.480 | |
| 4f3g | KAI | Glutamate receptor 3 | / | 0.479 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.478 | |
| 3m0e | ATP | Transcriptional regulator (NtrC family) | / | 0.478 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.478 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.477 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.477 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.476 | |
| 2j4k | U5P | Uridylate kinase | 2.7.4.22 | 0.476 | |
| 2qc8 | ADP | Glutamine synthetase | 6.3.1.2 | 0.476 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.476 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.476 | |
| 4ffr | ATP | Uncharacterized protein | / | 0.476 | |
| 1i5b | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.475 | |
| 4tld | AGS | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.475 | |
| 2toh | HBI | Tyrosine 3-monooxygenase | 1.14.16.2 | 0.474 | |
| 2z4s | ADP | Chromosomal replication initiator protein DnaA | / | 0.474 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 1z5a | ADP | Type 2 DNA topoisomerase 6 subunit B | / | 0.473 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.473 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 3ghh | 2NF | CD38 molecule | / | 0.471 | |
| 2d3a | ADP | Glutamine synthetase root isozyme 3 | 6.3.1.2 | 0.470 | |
| 2i1m | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.470 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.469 | |
| 1lco | PPY | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.469 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.469 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.469 | |
| 1z5c | ADP | Type 2 DNA topoisomerase 6 subunit B | / | 0.468 | |
| 2ejz | SAH | Diphthine synthase | / | 0.468 | |
| 2pbz | ATP | Uncharacterized protein | / | 0.468 | |
| 3ahe | THD | Probable phosphoketolase | / | 0.468 | |
| 3ahj | TPP | Probable phosphoketolase | / | 0.468 | |
| 1aj2 | 2PH | Dihydropteroate synthase | / | 0.467 | |
| 1i5c | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.467 | |
| 1lbb | KAI | Glutamate receptor 2 | / | 0.467 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.467 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.467 | |
| 3ahi | HTL | Probable phosphoketolase | / | 0.467 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.467 | |
| 4n8i | COA | Putative 4-hydroxybutyrate coenzyme A transferase | / | 0.467 | |
| 4pt3 | NDP | Aldehyde dehydrogenase | / | 0.467 | |
| 5iot | UMP | Flavin-dependent thymidylate synthase | 2.1.1.148 | 0.467 | |
| 2i0v | 6C3 | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.466 | |
| 2ior | ADP | Chaperone protein HtpG | / | 0.466 | |
| 2yej | XQK | Heat shock protein HSP 90-alpha | / | 0.466 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1e8z | STU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.465 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.465 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.465 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.465 | |
| 2ylw | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.465 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.465 | |
| 3bea | IXH | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.465 | |
| 3ceh | AVE | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.465 | |
| 1r2j | FAD | FkbI | / | 0.464 | |
| 1upc | TPP | N(2)-(2-carboxyethyl)arginine synthase | / | 0.464 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.464 | |
| 4yco | FMN | tRNA-dihydrouridine(16) synthase | / | 0.464 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.463 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 2xf3 | J01 | Uncharacterized protein | / | 0.462 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.462 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.461 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 2xiq | 5AD | Methylmalonyl-CoA mutase, mitochondrial | / | 0.461 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.461 | |
| 5dst | SAH | Protein arginine N-methyltransferase 8 | 2.1.1 | 0.461 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 3fmz | 2T1 | Retinol-binding protein 4 | / | 0.460 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 4jdc | NAD | Probable pyrroline-5-carboxylate dehydrogenase RocA | / | 0.460 | |
| 1e94 | ANP | ATP-dependent protease ATPase subunit HslU | / | 0.459 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.459 | |
| 2b8j | ADN | Class B acid phosphatase | 3.1.3.2 | 0.459 | |
| 2jfz | 003 | Glutamate racemase | / | 0.459 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.459 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.459 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.459 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 1u2g | APR | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.458 | |
| 2eit | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.458 | |
| 2fk8 | SAM | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.458 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2ylr | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.458 | |
| 3keu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.458 | |
| 4gxs | 0YS | Glutamate receptor 2 | / | 0.458 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.458 | |
| 4yaf | 2AM | NADPH--cytochrome P450 reductase | / | 0.458 | |
| 5c80 | URI | Uridine phosphorylase | / | 0.458 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2b82 | ADN | Class B acid phosphatase | 3.1.3.2 | 0.457 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.457 | |
| 3dds | 26B | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.457 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.457 | |
| 3l9m | L9M | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.457 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.457 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.456 | |
| 2qll | PLP | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.456 | |
| 2vxo | XMP | GMP synthase [glutamine-hydrolyzing] | 6.3.5.2 | 0.456 | |
| 2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.456 | |
| 3b9l | AZZ | Serum albumin | / | 0.456 | |
| 3gts | D3M | DdmC | / | 0.456 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.456 | |
| 3ruc | UD2 | UDP-N-acetylglucosamine 4-epimerase | / | 0.456 | |
| 3zhr | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.456 | |
| 4blc | NDP | Catalase | 1.11.1.6 | 0.456 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.456 | |
| 1qm5 | PLP | Maltodextrin phosphorylase | 2.4.1.1 | 0.455 | |
| 2ehu | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.455 | |
| 2fje | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.455 | |
| 2xvv | 9DN | Serum albumin | / | 0.455 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.455 | |
| 3zhu | TD8 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.455 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.455 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 1mx0 | ANP | Type 2 DNA topoisomerase 6 subunit B | / | 0.454 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.454 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.454 | |
| 3zns | NU7 | Histone deacetylase 7 | 3.5.1.98 | 0.454 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.454 | |
| 4uz6 | SCR | Palmitoleoyl-protein carboxylesterase NOTUM | / | 0.454 | |
| 4y6n | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.454 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.453 | |
| 1ftl | DNQ | Glutamate receptor 2 | / | 0.453 | |
| 2xls | NAP | Putative flavin-containing monooxygenase | / | 0.453 | |
| 3nf8 | CDQ | Gag-Pol polyprotein | / | 0.453 | |
| 3q3c | NAD | NAD-dependent L-serine dehydrogenase | / | 0.453 | |
| 4bqg | 50Q | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 4ffl | ADP | Uncharacterized protein | / | 0.453 | |
| 4ko8 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.453 | |
| 4ovi | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.453 | |
| 2bpo | FAD | NADPH--cytochrome P450 reductase | / | 0.452 | |
| 2g1a | 5HG | Class B acid phosphatase | 3.1.3.2 | 0.452 | |
| 2ilu | NDP | Lactaldehyde dehydrogenase | 1.2.1.22 | 0.452 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.452 | |
| 2onp | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.452 | |
| 3kr6 | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.452 | |
| 3qiz | QI2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.452 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 4br0 | AU1 | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.452 | |
| 4ug9 | 1EW | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.452 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.451 | |
| 1odn | APV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1ri1 | GTG | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.451 | |
| 2bfa | CB3 | Pteridine reductase 1 | 1.5.1.33 | 0.451 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.451 | |
| 2iut | AGS | DNA translocase FtsK | / | 0.451 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.451 | |
| 2xgo | ZKD | Uncharacterized protein | / | 0.451 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.451 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.451 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.451 | |
| 4ajg | F07 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 1g41 | ADP | ATP-dependent protease ATPase subunit HslU | / | 0.450 | |
| 1hsk | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.450 | |
| 1i5a | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.450 | |
| 1zdw | FLV | Prenyltransferase | / | 0.450 | |
| 3hu1 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.450 | |
| 3il4 | ACO | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | / | 0.450 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 4fxf | ATP | Pyruvate kinase PKM | 2.7.1.40 | 0.450 | |
| 4ihi | NAD | Probable pyrroline-5-carboxylate dehydrogenase RocA | / | 0.450 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.449 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.449 | |
| 2pui | ADP | Methylthioribose kinase | 2.7.1.100 | 0.449 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.449 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.449 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.449 | |
| 3dd1 | 25D | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.449 | |
| 3h65 | I2C | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 0.449 | |
| 3hdq | GDU | UDP-galactopyranose mutase | / | 0.449 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.449 | |
| 4gi4 | 0EX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.449 | |
| 1i24 | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.448 | |
| 1ta6 | 177 | Prothrombin | 3.4.21.5 | 0.448 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.448 | |
| 2eii | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.448 | |
| 3hdy | GDU | UDP-galactopyranose mutase | / | 0.448 | |
| 3l9n | L9N | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.448 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.448 | |
| 3up4 | NAP | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.448 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.448 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 1fml | RTL | Retinol dehydratase | / | 0.447 | |
| 1i58 | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.447 | |
| 1kek | HTL | Pyruvate synthase | / | 0.447 | |
| 1qzf | CB3 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.447 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.447 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.447 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.447 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.447 | |
| 3jzi | JZL | Biotin carboxylase | 6.3.4.14 | 0.447 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 3swq | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.447 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.447 | |
| 4fh5 | UTP | Terminal uridylyltransferase cid1 | / | 0.447 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.447 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.447 | |
| 1efa | NPF | Lactose operon repressor | / | 0.446 | |
| 1fw0 | KAI | Glutamate receptor 2 | / | 0.446 | |
| 1kmy | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.446 | |
| 1q3g | UDA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.446 | |
| 1ra3 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.446 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.446 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.446 | |
| 2bhp | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.446 | |
| 2cmo | M1L | Glutamate receptor 2 | / | 0.446 | |
| 2v3w | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.446 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.446 | |
| 3pvc | FAD | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | / | 0.446 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.446 | |
| 4aoa | IK2 | Beta-phenylalanine transaminase | 2.6.1 | 0.446 | |
| 4f3x | NAD | Putative aldehyde dehydrogenase | / | 0.446 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 5doz | NDP | JamJ | / | 0.446 | |
| 1i59 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.445 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.445 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.445 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.445 | |
| 1xzq | FON | tRNA modification GTPase MnmE | 3.6.5 | 0.445 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.445 | |
| 2daa | DCS | D-alanine aminotransferase | 2.6.1.21 | 0.445 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 2oeg | UPG | UDP-glucose pyrophosphorylase | / | 0.445 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.445 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.445 | |
| 2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 3ha3 | SAH | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.445 | |
| 3hko | ANP | Calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands | / | 0.445 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.445 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.445 | |
| 3sdk | P3N | Proteasome subunit beta type-5 | 3.4.25.1 | 0.445 | |
| 3sdk | P3N | Proteasome subunit beta type-6 | 3.4.25.1 | 0.445 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 3zhq | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.445 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.445 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.445 | |
| 4lb2 | DM5 | Serum albumin | / | 0.445 | |
| 4rbs | 0RV | Metallo-beta-lactamase type 2 | / | 0.445 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.445 | |
| 5gcn | COA | HAT A1 | / | 0.445 | |
| 5iw5 | NMN | NADH pyrophosphatase | / | 0.445 | |
| 1b87 | ACO | Aac(6')-Ii protein | / | 0.444 | |
| 1e92 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.444 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1kqg | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.444 | |
| 1omo | NAD | Alanine dehydrogenase | / | 0.444 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 1ypk | CCR | Prothrombin | 3.4.21.5 | 0.444 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.444 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.444 | |
| 2cn0 | F25 | Prothrombin | 3.4.21.5 | 0.444 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.444 | |
| 2rab | NAD | Glutathione amide reductase | / | 0.444 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.444 | |
| 2zs9 | ADP | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 3af2 | ACP | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 3akk | ADP | Serine/threonine-protein kinase CtkA | 2.7.11.1 | 0.444 | |
| 3hu3 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.444 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.444 | |
| 3rl3 | 5GP | Metallophosphoesterase MPPED2 | 3.1 | 0.444 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.444 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.444 | |
| 4fhj | 0TZ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4m2b | UPG | UDP-glucose pyrophosphorylase | / | 0.444 | |
| 4rpg | GDU | UDP-galactopyranose mutase | 5.4.99.9 | 0.444 | |
| 4umx | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.444 | |
| 1f9a | ATP | Nicotinamide-nucleotide adenylyltransferase | / | 0.443 | |
| 1g4s | TPS | Thiamine-phosphate synthase | / | 0.443 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.443 | |
| 1ppj | ANY | Cytochrome b | / | 0.443 | |
| 1u9i | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.443 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 1zs6 | ADP | Nucleoside diphosphate kinase 3 | 2.7.4.6 | 0.443 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 3c34 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.443 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.443 | |
| 3qvr | FAD | Glucose oxidase | 1.1.3.4 | 0.443 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4bix | ADP | Sensor histidine kinase CpxA | / | 0.443 | |
| 4ixd | 1HV | Integrin alpha-L | / | 0.443 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.442 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.442 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.442 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.442 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.442 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.442 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.442 | |
| 3ogk | OGK | Coronatine-insensitive protein 1 | / | 0.442 | |
| 3owj | 1EL | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.442 | |
| 3vcy | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.442 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.442 | |
| 4req | 5AD | Methylmalonyl-CoA mutase large subunit | 5.4.99.2 | 0.442 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.442 | |
| 1fxv | PNN | Penicillin G acylase | 3.5.1.11 | 0.441 | |
| 1knp | FAD | L-aspartate oxidase | 1.4.3.16 | 0.441 | |
| 1n1d | C2G | Glycerol-3-phosphate cytidylyltransferase | 2.7.7.39 | 0.441 | |
| 1r4l | XX5 | Angiotensin-converting enzyme 2 | 3.4.17.23 | 0.441 | |
| 1tf7 | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.441 | |
| 1um0 | FMN | Chorismate synthase | / | 0.441 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.441 | |
| 1uvs | I11 | Prothrombin | 3.4.21.5 | 0.441 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 2c3y | HTL | Pyruvate synthase | / | 0.441 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.441 | |
| 2p6l | SAH | Diphthine synthase | / | 0.441 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2qxx | TTP | dCTP deaminase | 3.5.4.13 | 0.441 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.441 | |
| 3ezp | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.441 | |
| 3fd6 | ADP | Selenide, water dikinase 1 | 2.7.9.3 | 0.441 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.441 | |
| 3keq | NAD | Redox-sensing transcriptional repressor Rex | / | 0.441 | |
| 3koz | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.441 | |
| 3kt3 | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.441 | |
| 3pd5 | TSB | Threonine--tRNA ligase | 6.1.1.3 | 0.441 | |
| 4a33 | PS8 | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4k39 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.441 | |
| 4lv8 | ADP | Rhoptry protein 5 C | / | 0.441 | |
| 4rn6 | 15U | Prothrombin | 3.4.21.5 | 0.441 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.440 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1w7h | 3IP | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 1yqj | 6NP | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 2ag0 | TPP | Benzaldehyde lyase | / | 0.440 | |
| 2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2re8 | GSU | Glutamine--tRNA ligase | 6.1.1.18 | 0.440 | |
| 2xvw | 9NR | Serum albumin | / | 0.440 | |
| 2ym1 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.440 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.440 | |
| 3evb | SAH | Genome polyprotein | 2.1.1.56 | 0.440 | |
| 3tr9 | PT1 | Dihydropteroate synthase | / | 0.440 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4f70 | 0ST | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.440 | |
| 4hkf | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.440 | |
| 4phl | PIL | Phosphodiesterase | / | 0.440 | |
| 4utk | FNR | Xenobiotic reductase | / | 0.440 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.440 |