sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5fa1 | C5P | Putative N-acetyl glucosaminyl transferase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 5fa1 | C5P | Putative N-acetyl glucosaminyl transferase | / | 1.000 | |
| 2y3p | SM8 | DNA gyrase subunit A | / | 0.513 | |
| 3b2s | B2S | Trichothecene 3-O-acetyltransferase | / | 0.501 | |
| 1dgm | ADN | Adenosine kinase | 2.7.1.20 | 0.496 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.492 | |
| 3s87 | ADP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.488 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.486 | |
| 1hwz | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.482 | |
| 4fv3 | EK6 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.479 | |
| 4ie0 | PD2 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.479 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.478 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.478 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.478 | |
| 1g0r | THM | Glucose-1-phosphate thymidylyltransferase | / | 0.477 | |
| 1z3c | SA8 | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.477 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.476 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.476 | |
| 4loh | 1SY | Stimulator of interferon genes protein | / | 0.476 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.475 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase alpha chain | 1.13.11.3 | 0.475 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.475 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.475 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.475 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.474 | |
| 2y3s | TIR | TamL | / | 0.474 | |
| 3bv2 | P38 | Mitogen-activated protein kinase 14 | / | 0.474 | |
| 3eld | SFG | Methyltransferase | / | 0.474 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.474 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.473 | |
| 3fr4 | F8A | Fatty acid-binding protein, adipocyte | / | 0.473 | |
| 3hko | ANP | Calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands | / | 0.473 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.473 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.473 | |
| 1xq6 | NAP | Uncharacterized protein At5g02240 | / | 0.472 | |
| 2rl1 | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.472 | |
| 3cvu | FAD | RE11660p | / | 0.472 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.472 | |
| 1m9a | GTX | Glutathione S-transferase class-mu 26 kDa isozyme | 2.5.1.18 | 0.471 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.471 | |
| 3g11 | P9C | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.471 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.470 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.470 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.470 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.469 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.469 | |
| 3b9l | AZZ | Serum albumin | / | 0.469 | |
| 4f6w | 0SS | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.469 | |
| 4n57 | ADP | APH(2'')-Id | / | 0.469 | |
| 1p4a | PCP | Pur operon repressor | / | 0.468 | |
| 2xvq | 9DS | Serum albumin | / | 0.467 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.467 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.467 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 4c72 | TLG | 3-oxoacyl-ACP synthase | / | 0.467 | |
| 1u0h | FOK | Adenylate cyclase type 2 | / | 0.466 | |
| 1u0h | FOK | Adenylate cyclase type 5 | / | 0.466 | |
| 3pcg | 4HP | Protocatechuate 3,4-dioxygenase alpha chain | 1.13.11.3 | 0.466 | |
| 3pcg | 4HP | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.466 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.465 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.465 | |
| 1xjn | CDP | Vitamin B12-dependent ribonucleotide reductase | / | 0.465 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.465 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.465 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.465 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.465 | |
| 4u7w | NDP | MxaA | / | 0.465 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 1esv | LAR | Actin, alpha skeletal muscle | / | 0.464 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.464 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.464 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.464 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.464 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.463 | |
| 2dbz | NAP | Glyoxylate reductase | 1.1.1.26 | 0.463 | |
| 3td7 | FAD | Probable FAD-linked sulfhydryl oxidase R596 | 1.8.3.2 | 0.463 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.462 | |
| 1g4o | BSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.462 | |
| 1osv | CHC | Bile acid receptor | / | 0.462 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.462 | |
| 2bro | DF2 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 2dxv | SAH | Diphthine synthase | / | 0.462 | |
| 3mt8 | 17T | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.462 | |
| 3qiz | QI2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.462 | |
| 4ddh | MS0 | Pantothenate synthetase | 6.3.2.1 | 0.462 | |
| 4mv3 | ACP | Biotin carboxylase | 6.3.4.14 | 0.462 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.462 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.461 | |
| 3vi5 | M4M | Hematopoietic prostaglandin D synthase | / | 0.461 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.461 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.460 | |
| 3pch | CHB | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.460 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.459 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.459 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.459 | |
| 3w77 | FMN | FMN-dependent NADH-azoreductase | / | 0.459 | |
| 1kvu | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.458 | |
| 2d8a | NAD | L-threonine 3-dehydrogenase | / | 0.458 | |
| 3eku | CY9 | Actin-5C | / | 0.458 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.458 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.458 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 4i8x | 6P3 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.458 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.458 | |
| 2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.457 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.457 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.457 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.457 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.457 | |
| 5cyo | GDP | Septin-9 | / | 0.457 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.456 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.456 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.456 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.456 | |
| 2bxf | DZP | Serum albumin | / | 0.456 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.456 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.456 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.456 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.456 | |
| 4yp1 | 2BA | Stimulator of interferon genes protein | / | 0.456 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.456 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.455 | |
| 3cx4 | ADP | Glycogen synthase | 2.4.1.21 | 0.455 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.455 | |
| 3gon | ANP | Phosphomevalonate kinase | / | 0.455 | |
| 3vi7 | CBD | Hematopoietic prostaglandin D synthase | / | 0.455 | |
| 4ck2 | NVU | Integrase | / | 0.455 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.455 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.455 | |
| 1m75 | CAA | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.454 | |
| 1wpg | ADP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.454 | |
| 1ykf | NAP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.454 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.454 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.454 | |
| 3qfc | NAP | NADPH--cytochrome P450 reductase | / | 0.454 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.454 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.453 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.453 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.453 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.453 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.453 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.453 | |
| 2q46 | NAP | Uncharacterized protein At5g02240 | / | 0.453 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.453 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.453 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3t2v | KKJ | Peptidoglycan recognition protein 1 | / | 0.453 | |
| 3up5 | NAP | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.453 | |
| 4bew | ACP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.453 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.453 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.453 | |
| 4oi4 | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.453 | |
| 4rvd | SAM | D-mycarose 3-C-methyltransferase | / | 0.453 | |
| 4u0o | MTA | Lipoyl synthase 2 | / | 0.453 | |
| 5bt9 | NAP | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.453 | |
| 1a4i | NDP | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.452 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.452 | |
| 1hku | NAD | C-terminal-binding protein 1 | 1.1.1 | 0.452 | |
| 1k6v | XN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 2aqb | TL6 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.452 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.452 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.452 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.452 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.452 | |
| 3dkv | AP5 | Adenylate kinase | / | 0.452 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.452 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.452 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.452 | |
| 4cfb | OM3 | Integrase | / | 0.452 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.452 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.452 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.451 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.451 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.451 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.451 | |
| 1l8q | ADP | Chromosomal replication initiator protein DnaA | / | 0.451 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.451 | |
| 2oo7 | AP5 | Adenylate kinase | / | 0.451 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.451 | |
| 2qen | ADP | Walker-Type ATPase | / | 0.451 | |
| 2rhg | IGP | Tryptophan synthase alpha chain | / | 0.451 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.451 | |
| 2xfy | ACX | Beta-amylase | 3.2.1.2 | 0.451 | |
| 3gep | 24H | Hypoxanthine-guanine phosphoribosyltransferase | 2.4.2.8 | 0.451 | |
| 3mgd | ACO | Predicted acetyltransferase | / | 0.451 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.451 | |
| 3qvp | FAD | Glucose oxidase | 1.1.3.4 | 0.451 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 4k42 | ADP | Actin, alpha skeletal muscle | / | 0.451 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.451 | |
| 4ozn | ATP | Ammonium transporter | / | 0.451 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.450 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.450 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.450 | |
| 2gfx | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.450 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.450 | |
| 3hgr | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.450 | |
| 4fvr | ATP | Tyrosine-protein kinase JAK2 | / | 0.450 | |
| 4tx9 | AMZ | Phosphoribosyl isomerase A | / | 0.450 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.450 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.450 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.449 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 1h61 | PDN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 1u2y | GOX | Pancreatic alpha-amylase | / | 0.449 | |
| 1wuu | ANP | Galactokinase | 2.7.1.6 | 0.449 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.449 | |
| 1ytm | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.449 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.449 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.449 | |
| 2eud | GCQ | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.449 | |
| 2jlb | UDM | Uncharacterized protein | / | 0.449 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.449 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.449 | |
| 2xw1 | 9NV | Serum albumin | / | 0.449 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.449 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.449 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.449 | |
| 3m6i | NAD | L-arabinitol 4-dehydrogenase | 1.1.1.12 | 0.449 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.449 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.449 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.449 | |
| 4lol | 1YE | Stimulator of interferon genes protein | / | 0.449 | |
| 4qxr | 1YE | Stimulator of interferon genes protein | / | 0.449 | |
| 4xr9 | NAD | CalS8 | / | 0.449 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.448 | |
| 1ybm | NAP | Uncharacterized protein At5g02240 | / | 0.448 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.448 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 3c16 | FOK | Adenylate cyclase type 2 | / | 0.448 | |
| 3c16 | FOK | Adenylate cyclase type 5 | / | 0.448 | |
| 3i25 | MV7 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3ogw | IMN | Lactoperoxidase | 1.11.1.7 | 0.448 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.448 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.448 | |
| 3vcy | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.448 | |
| 3wb2 | YGP | Uncharacterized protein MJ0488 | / | 0.448 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.448 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.448 | |
| 4gnc | ASO | Regucalcin | 3.1.1.17 | 0.448 | |
| 4i4b | 1CV | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.448 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.448 | |
| 1fk8 | NAD | 3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase | 1.1.1.50 | 0.447 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
| 1svm | ATP | Large T antigen | 3.6.4 | 0.447 | |
| 2g76 | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.447 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.447 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.447 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.447 | |
| 2x7b | COA | N-alpha-acetyltransferase | 2.3.1 | 0.447 | |
| 3hpq | AP5 | Adenylate kinase | / | 0.447 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.447 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.447 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.447 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.447 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.447 | |
| 4fry | NAD | Putative signal-transduction protein with CBS domains | / | 0.447 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.447 | |
| 4v02 | ATP | Site-determining protein | / | 0.447 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.446 | |
| 1sxj | AGS | Replication factor C subunit 1 | / | 0.446 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.446 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.446 | |
| 2eka | SAH | Diphthine synthase | / | 0.446 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.446 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.446 | |
| 3eks | CY9 | Actin-5C | / | 0.446 | |
| 3fgo | ACP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.446 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.446 | |
| 3mpt | 1GK | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3rlq | 3RQ | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3vr8 | RQX | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | / | 0.446 | |
| 3vr8 | RQX | Cytochrome b-large subunit | / | 0.446 | |
| 4f70 | 0ST | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.446 | |
| 4f9g | C2E | Stimulator of interferon genes protein | / | 0.446 | |
| 4n3c | UD1 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.446 | |
| 5i4n | ATP | Tyrosine-protein kinase JAK2 | / | 0.446 | |
| 1k8y | 13P | Tryptophan synthase alpha chain | / | 0.445 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.445 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.445 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.445 | |
| 2owk | SAH | Diphthine synthase | / | 0.445 | |
| 2v34 | CTN | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.445 | |
| 2vnj | NAP | NADPH:ferredoxin reductase | / | 0.445 | |
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 | / | 0.445 | |
| 3gy9 | COA | GCN5-related N-acetyltransferase | / | 0.445 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.445 | |
| 3ozc | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.445 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.445 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.445 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.445 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.445 | |
| 1g2v | TTP | Glucose-1-phosphate thymidylyltransferase | / | 0.444 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.444 | |
| 1ttm | 667 | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.444 | |
| 2dsg | SAH | Diphthine synthase | / | 0.444 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.444 | |
| 2q3f | GNP | Ras-related GTP-binding protein D | / | 0.444 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.444 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2xvw | 9NR | Serum albumin | / | 0.444 | |
| 2ym5 | YM5 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3mn6 | ATP | Actin-5C | / | 0.444 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3w23 | 3RO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.444 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4y6u | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.444 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.444 | |
| 5il1 | SAM | N6-adenosine-methyltransferase 70 kDa subunit | / | 0.444 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.443 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.443 | |
| 2aq7 | TL5 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.443 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2ipj | FFA | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 2ohv | NHL | Glutamate racemase | / | 0.443 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.443 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3a62 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.443 | |
| 3bsy | ACO | UDP-N-acetylbacillosamine N-acetyltransferase | 2.3.1.203 | 0.443 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.443 | |
| 4a4z | ANP | Antiviral helicase SKI2 | 3.6.4.13 | 0.443 | |
| 4a61 | ANP | Plasmid segregation protein ParM | / | 0.443 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.443 | |
| 4eqw | FAD | Coenzyme A disulfide reductase | / | 0.443 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.443 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.443 | |
| 4r3k | COA | N-alpha-acetyltransferase | 2.3.1 | 0.443 | |
| 4r7u | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.443 | |
| 4uoc | NCN | CinA-like protein | / | 0.443 | |
| 4uov | AZM | Carbonate dehydratase | / | 0.443 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.443 | |
| 4yco | FMN | tRNA-dihydrouridine(16) synthase | / | 0.443 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1bof | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.442 | |
| 1ci0 | FMN | Pyridoxamine 5'-phosphate oxidase | 1.4.3.5 | 0.442 | |
| 1fxf | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.442 | |
| 1h6b | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.442 | |
| 1i24 | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.442 | |
| 1i91 | INQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.442 | |
| 1iay | AVG | 1-aminocyclopropane-1-carboxylate synthase 2 | 4.4.1.14 | 0.442 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1qyx | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1sby | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.442 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.442 | |
| 1wng | SAH | Diphthine synthase | / | 0.442 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2cvq | NDP | Malate dehydrogenase | / | 0.442 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.442 | |
| 2hux | SAH | Diphthine synthase | / | 0.442 | |
| 2rgx | AP5 | Adenylate kinase | / | 0.442 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.442 | |
| 2tpr | FAD | Trypanothione reductase | 1.8.1.12 | 0.442 | |
| 3axw | TID | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.442 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.442 | |
| 3tnl | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 3u9e | COA | Lmo1369 protein | / | 0.442 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.442 | |
| 3w8r | ACP | Uridine kinase | / | 0.442 | |
| 4azm | T4B | Fatty acid-binding protein, epidermal | / | 0.442 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.442 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.442 | |
| 5bsf | NAD | Pyrroline-5-carboxylate reductase | / | 0.442 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.441 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.441 | |
| 2c3k | ABO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2cbs | R13 | Cellular retinoic acid-binding protein 2 | / | 0.441 | |
| 2olr | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.441 | |
| 2owv | SAH | Diphthine synthase | / | 0.441 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.441 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.441 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.441 | |
| 3elm | 24F | Collagenase 3 | 3.4.24 | 0.441 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.441 | |
| 3kjg | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.441 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.441 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.441 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.441 | |
| 3tyd | XHP | Dihydropteroate synthase | / | 0.441 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 4ho9 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.441 | |
| 5dp2 | NAP | CurF | / | 0.441 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 1cjv | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cjv | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1gil | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.440 | |
| 1hk2 | T44 | Serum albumin | / | 0.440 | |
| 1k27 | MTM | S-methyl-5'-thioadenosine phosphorylase | / | 0.440 | |
| 1mra | APG | Mandelate racemase | / | 0.440 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.440 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.440 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.440 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.440 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.440 | |
| 3cd3 | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.440 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.440 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 3gvi | ADP | Malate dehydrogenase | / | 0.440 | |
| 3lcj | COA | Phosphopantetheine adenylyltransferase | / | 0.440 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.440 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.440 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.440 | |
| 3rj9 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.440 | |
| 3tvq | DQH | Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN | 2.1.1 | 0.440 | |
| 3zhr | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.440 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.440 | |
| 4b42 | 942 | Glucose-1-phosphate thymidylyltransferase | / | 0.440 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4o2b | LOC | Tubulin beta-2B chain | / | 0.440 | |
| 4ojb | 198 | Androgen receptor | / | 0.440 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4xq6 | FMN | Dihydroorotate dehydrogenase (quinone) | / | 0.440 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.440 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.440 |