sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2xnc | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2xnc | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 1.000 | |
| 3mhp | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.629 | |
| 1gjr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.618 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.607 | |
| 3w5u | FAD | Ferredoxin | / | 0.602 | |
| 3fpk | FAD | Ferredoxin-NADP reductase | / | 0.590 | |
| 4af7 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.588 | |
| 1h85 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.586 | |
| 1qh0 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.585 | |
| 1ja1 | FAD | NADPH--cytochrome P450 reductase | / | 0.584 | |
| 1w87 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.583 | |
| 1b2r | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.578 | |
| 1bx1 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.576 | |
| 3vo2 | FAD | Ferredoxin--NADP reductase | / | 0.571 | |
| 4y9r | FAD | NADPH--cytochrome P450 reductase | / | 0.568 | |
| 1w35 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.567 | |
| 1bjk | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.566 | |
| 2rc6 | FAD | Ferredoxin--NADP reductase | / | 0.565 | |
| 1fnc | FDA | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.562 | |
| 1go2 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.562 | |
| 4af6 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.562 | |
| 3qfs | FAD | NADPH--cytochrome P450 reductase | / | 0.557 | |
| 1qgy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.556 | |
| 1gaq | FAD | Ferredoxin | / | 0.555 | |
| 1e64 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.554 | |
| 1fnb | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.554 | |
| 4c43 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.554 | |
| 4yao | FAD | NADPH--cytochrome P450 reductase | / | 0.553 | |
| 1sm4 | FAD | Ferredoxin--NADP reductase | / | 0.552 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.550 | |
| 3ojx | FAD | NADPH--cytochrome P450 reductase | / | 0.547 | |
| 1gaw | FAD | Ferredoxin | / | 0.543 | |
| 2b5o | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.541 | |
| 3zbt | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.538 | |
| 4wqm | FAD | Toluene-4-monooxygenase electron transfer component | 1.18.1.3 | 0.538 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.537 | |
| 2r6h | FAD | Na(+)-translocating NADH-quinone reductase subunit F | / | 0.531 | |
| 1krh | FAD | Benzoate 1,2-dioxygenase electron transfer component | 1.18.1.3 | 0.528 | |
| 4bpr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.524 | |
| 1e63 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.519 | |
| 4uaj | FAD | Na(+)-translocating NADH-quinone reductase subunit F | / | 0.519 | |
| 3qft | FAD | NADPH--cytochrome P450 reductase | / | 0.514 | |
| 1amo | FAD | NADPH--cytochrome P450 reductase | / | 0.512 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.511 | |
| 1cqx | FAD | Flavohemoprotein | / | 0.508 | |
| 2ok8 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.507 | |
| 2rc5 | FAD | Ferredoxin--NADP reductase | / | 0.504 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.498 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.498 | |
| 1qgz | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.497 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.496 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.495 | |
| 1que | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.491 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.491 | |
| 1e62 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.489 | |
| 4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.489 | |
| 2aq7 | TL5 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.488 | |
| 3u8l | 09Q | Acetylcholine-binding protein | / | 0.486 | |
| 1fnd | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.485 | |
| 1ogj | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.485 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.485 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.482 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.482 | |
| 1fdr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.481 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.479 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.479 | |
| 3t4h | MD5 | Alpha-ketoglutarate-dependent dioxygenase AlkB | 1.14.11.33 | 0.479 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.478 | |
| 4fk8 | FAD | Ferredoxin--NADP reductase | / | 0.478 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.477 | |
| 2vnj | FAD | NADPH:ferredoxin reductase | / | 0.477 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.477 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.477 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.474 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.474 | |
| 1ogi | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.473 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.473 | |
| 1gvh | FAD | Flavohemoprotein | / | 0.472 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.471 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.471 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.471 | |
| 3ihz | FK5 | Peptidylprolyl isomerase | / | 0.471 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.471 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.471 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.470 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.470 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.469 | |
| 3c4h | DRL | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.469 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.468 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.468 | |
| 2oeg | UPG | UDP-glucose pyrophosphorylase | / | 0.468 | |
| 1dlj | UGA | UDP-glucose 6-dehydrogenase | / | 0.467 | |
| 1enp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.467 | |
| 1pwu | GM6 | Lethal factor | 3.4.24.83 | 0.467 | |
| 3ce0 | P34 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.467 | |
| 3h7r | NAP | Aldo-keto reductase family 4 member C8 | / | 0.467 | |
| 3k5g | BJC | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.467 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.467 | |
| 4gt8 | ADP | Sensor protein VraS | 2.7.13.3 | 0.467 | |
| 1c4v | IH2 | Prothrombin | 3.4.21.5 | 0.466 | |
| 1ewy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.466 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1n8w | COA | Malate synthase G | / | 0.466 | |
| 2ylr | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.466 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.466 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.466 | |
| 1h42 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.465 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1zx1 | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.465 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.465 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.465 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.465 | |
| 3e4v | FMN | Uncharacterized protein | / | 0.465 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.465 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.465 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.464 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.464 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.464 | |
| 2y67 | N21 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.464 | |
| 1w1w | AGS | Structural maintenance of chromosomes protein 1 | / | 0.463 | |
| 2j2p | SC2 | Ficolin-2 | / | 0.463 | |
| 3myt | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.463 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.463 | |
| 3qfc | FAD | NADPH--cytochrome P450 reductase | / | 0.463 | |
| 4bri | UNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.463 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.463 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.462 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.462 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.462 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.462 | |
| 3h0v | M2T | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.462 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.462 | |
| 4l9q | 9TP | Serum albumin | / | 0.462 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.462 | |
| 2e8q | SAH | Diphthine synthase | / | 0.461 | |
| 2zrv | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.461 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.461 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.461 | |
| 4b4d | FAD | Ferredoxin-NADP reductase | / | 0.461 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.460 | |
| 1m8k | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.460 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.460 | |
| 2v5u | FMN | Flavodoxin | / | 0.460 | |
| 3gqo | APR | Non-structural polyprotein | / | 0.460 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.460 | |
| 1fvp | FMA | Non-fluorescent flavoprotein | / | 0.459 | |
| 1gj4 | 132 | Prothrombin | 3.4.21.5 | 0.459 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.459 | |
| 3faz | NOS | Purine nucleoside phosphorylase | / | 0.459 | |
| 3qiz | QI2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.459 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 1j78 | VDY | Vitamin D-binding protein | / | 0.458 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.458 | |
| 2b8j | ADN | Class B acid phosphatase | 3.1.3.2 | 0.458 | |
| 2v0u | FMN | NPH1-1 | / | 0.458 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.458 | |
| 3lcj | COA | Phosphopantetheine adenylyltransferase | / | 0.458 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.458 | |
| 4lsj | LSJ | Glucocorticoid receptor | / | 0.458 | |
| 1xp8 | AGS | Protein RecA | / | 0.457 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.457 | |
| 2j9g | ANP | Biotin carboxylase | 6.3.4.14 | 0.457 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.457 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.457 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.457 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.456 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.456 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.456 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.456 | |
| 2gz8 | F3F | Orf1a polyprotein | / | 0.456 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.456 | |
| 2vr1 | ATF | Biotin carboxylase | 6.3.4.14 | 0.456 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.456 | |
| 3oia | A31 | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.456 | |
| 4blr | UTP | NTPase P4 | / | 0.456 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.456 | |
| 4ovi | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.456 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.455 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.455 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.455 | |
| 2zse | ACP | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.455 | |
| 3eku | CY9 | Actin-5C | / | 0.455 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.455 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.455 | |
| 1q4t | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.454 | |
| 1til | ATP | Anti-sigma F factor | / | 0.454 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.454 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 2pch | SAH | Diphthine synthase | / | 0.454 | |
| 2reh | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.454 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.454 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.454 | |
| 3hnz | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.454 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.454 | |
| 4l0o | PLP | Cystathionine gamma-synthase | 2.5.1.48 | 0.454 | |
| 5a4w | QCT | Glutathione S-transferase F2 | 2.5.1.18 | 0.454 | |
| 1a26 | CNA | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.453 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.453 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.453 | |
| 1s2c | FLF | Aldo-keto reductase family 1 member C3 | / | 0.453 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.453 | |
| 2vqz | MGT | Polymerase basic protein 2 | / | 0.453 | |
| 3w6u | NAP | 6-phosphogluconate dehydrogenase, NAD-binding protein | / | 0.453 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.453 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.453 | |
| 3pbl | ETQ | D(3) dopamine receptor | / | 0.453 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.452 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.452 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.452 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.452 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.452 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.452 | |
| 2jh5 | 895 | Prothrombin | 3.4.21.5 | 0.452 | |
| 3anl | SYC | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.452 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.452 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.452 | |
| 4wx2 | F6F | Tryptophan synthase alpha chain | / | 0.452 | |
| 4wx2 | F6F | Tryptophan synthase beta chain | 4.2.1.20 | 0.452 | |
| 1ae8 | AZL | Prothrombin | 3.4.21.5 | 0.451 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.451 | |
| 2e16 | SAH | Diphthine synthase | / | 0.451 | |
| 2hl3 | GLU_GLU_TYR | Dynactin subunit 1 | / | 0.451 | |
| 2zsh | GA3 | Gibberellin receptor GID1A | 3 | 0.451 | |
| 3e2s | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.451 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 1fml | RTL | Retinol dehydratase | / | 0.450 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.450 | |
| 2z52 | H23 | Geranylgeranyl pyrophosphate synthase | / | 0.450 | |
| 3e6e | DCS | Alanine racemase | / | 0.450 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.450 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.450 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.450 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.450 | |
| 4ho6 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.450 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4z36 | ON3 | Lysophosphatidic acid receptor 1 | / | 0.450 | |
| 1x27 | ASP_ASP_TYR_VAL_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.449 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.449 | |
| 2ibw | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.449 | |
| 2xvv | 9DN | Serum albumin | / | 0.449 | |
| 3a6q | FMN | FMN-binding protein | / | 0.449 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.449 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.449 | |
| 3vx4 | ATP | Putative ABC transporter, ATP-binding protein ComA | / | 0.449 | |
| 3wqt | ANP | Cell division protein FtsA | / | 0.449 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4f6w | 0SS | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.449 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.449 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.449 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.449 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.449 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.448 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.448 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.448 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.448 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.448 | |
| 2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.448 | |
| 2dt5 | NAD | Redox-sensing transcriptional repressor Rex | / | 0.448 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.448 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.448 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.448 | |
| 3rba | COD | Phosphopantetheine adenylyltransferase | / | 0.448 | |
| 3zhr | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.448 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4eqr | COA | Coenzyme A disulfide reductase | / | 0.448 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.448 | |
| 4p2l | FAD | Sulfhydryl oxidase 1 | 1.8.3.2 | 0.448 | |
| 1eqa | MG7 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase | 2.1.1.57 | 0.447 | |
| 1gr1 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.447 | |
| 1lb9 | DNQ | Glutamate receptor 2 | / | 0.447 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 2b36 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2p6l | SAH | Diphthine synthase | / | 0.447 | |
| 3e8x | NAP | BH1520 protein | / | 0.447 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.447 | |
| 3isj | A8D | Pantothenate synthetase | 6.3.2.1 | 0.447 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.447 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4je5 | PLP | Aromatic/aminoadipate aminotransferase 1 | 2.6.1.39 | 0.447 | |
| 4rr6 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.447 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.447 | |
| 1mxf | MTX | Putative pteridine reductase 2 | / | 0.446 | |
| 1qjg | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.446 | |
| 1vce | SAH | Diphthine synthase | / | 0.446 | |
| 1wm1 | PTB | Proline iminopeptidase | 3.4.11.5 | 0.446 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.446 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.446 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.446 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 2zts | ADP | Uncharacterized protein | / | 0.446 | |
| 3bbd | SAH | Ribosomal RNA small subunit methyltransferase Nep1 | 2.1.1 | 0.446 | |
| 3dhc | CYK | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.446 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.446 | |
| 3m2u | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.446 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 3wqu | ATP | Cell division protein FtsA | / | 0.446 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.446 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.445 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.445 | |
| 1wl4 | COA | Acetyl-CoA acetyltransferase, cytosolic | 2.3.1.9 | 0.445 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.445 | |
| 2egl | SAH | Diphthine synthase | / | 0.445 | |
| 2emr | SAH | Diphthine synthase | / | 0.445 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.445 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.445 | |
| 3n3a | FMN | Protein NrdI | / | 0.445 | |
| 4ai8 | DZA | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.445 | |
| 4brd | ANP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.445 | |
| 4gfv | PRO_GLU_LEU_THR_PTR | Tyrosine-protein phosphatase non-receptor type 18 | 3.1.3.48 | 0.445 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4jzr | 4JR | Egl nine homolog 1 | / | 0.445 | |
| 4nce | MGT | Polymerase basic protein 2 | / | 0.445 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1eio | GCH | Gastrotropin | / | 0.444 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1ptj | NAP | NAD(P) transhydrogenase subunit beta | 1.6.1.2 | 0.444 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.444 | |
| 1t4c | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.444 | |
| 2avx | HTF | Regulatory protein SdiA | / | 0.444 | |
| 2b9y | FAD | Putative aminooxidase | / | 0.444 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.444 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2ejz | SAH | Diphthine synthase | / | 0.444 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3l05 | SN0 | N-acetylornithine carbamoyltransferase | 2.1.3.9 | 0.444 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.444 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.444 | |
| 4jau | ADP | Sensor histidine kinase | / | 0.444 | |
| 4kp7 | 1UQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.444 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.444 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.444 | |
| 4nhy | PD2 | Prolyl 3-hydroxylase OGFOD1 | 1.14.11 | 0.444 | |
| 4plp | NAD | Homospermidine synthase | 2.5.1.44 | 0.444 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.444 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.443 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.443 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.443 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1j0x | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.443 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.443 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3eks | CY9 | Actin-5C | / | 0.443 | |
| 3jqr | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.443 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3pn1 | IVH | DNA ligase | / | 0.443 | |
| 3r1r | ATP | Ribonucleoside-diphosphate reductase 1 subunit alpha | 1.17.4.1 | 0.443 | |
| 3thy | ADP | DNA mismatch repair protein Msh2 | / | 0.443 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4boe | CLR | Japanin | / | 0.443 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.443 | |
| 4kug | NAD | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.443 | |
| 4phl | PIL | Phosphodiesterase | / | 0.443 | |
| 4qtn | NNR | Nicotinamide riboside transporter PnuC | / | 0.443 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA2 | 3.6.3 | 0.443 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA1 | / | 0.443 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.442 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.442 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1mma | ADP | Myosin-2 heavy chain | / | 0.442 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.442 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.442 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.442 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.442 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.442 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.442 | |
| 2dsg | SAH | Diphthine synthase | / | 0.442 | |
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.442 | |
| 2yg4 | FAD | Putrescine oxidase | / | 0.442 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.442 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.442 | |
| 3b9l | AZZ | Serum albumin | / | 0.442 | |
| 3fuf | BES | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.442 | |
| 3ihg | VAK | Aklavinone 12-hydroxylase RdmE | / | 0.442 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.442 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.442 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.442 | |
| 4u15 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.442 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.441 | |
| 1ja0 | FAD | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.441 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.441 | |
| 2owf | SAH | Diphthine synthase | / | 0.441 | |
| 2z6r | SAH | Diphthine synthase | / | 0.441 | |
| 2ziq | 26U | Prothrombin | 3.4.21.5 | 0.441 | |
| 3bt9 | DEQ | HTH-type transcriptional regulator QacR | / | 0.441 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3ho2 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.441 | |
| 3lzx | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.441 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.441 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.441 | |
| 4djx | 0KQ | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.441 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 3vw7 | VPX | Proteinase-activated receptor 1 | / | 0.441 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.440 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.440 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.440 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.440 | |
| 2bpo | NAP | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 2e8h | SAH | Diphthine synthase | / | 0.440 | |
| 2vb8 | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.440 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 | |
| 2z4s | ADP | Chromosomal replication initiator protein DnaA | / | 0.440 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 3bi4 | 298 | Polyamine oxidase FMS1 | / | 0.440 | |
| 3ebl | GA4 | Gibberellin receptor GID1 | / | 0.440 | |
| 3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.440 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.440 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.440 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.440 | |
| 3v2b | AR6 | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.440 | |
| 3zvm | ADP | Bifunctional polynucleotide phosphatase/kinase | 2.7.1.78 | 0.440 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.440 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4eep | FMN | Phototropin-2 | 2.7.11.1 | 0.440 | |
| 4i0j | 842 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4ktf | 1TM | Cytochrome P450 | / | 0.440 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
| 4oxi | GAP | Enterobactin synthetase component F-related protein | / | 0.440 | |
| 5cp8 | TCU | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 5iqd | GNP | Bifunctional AAC/APH | 2.3.1 | 0.440 | |
| 5kgj | ACO | Predicted acetyltransferase | / | 0.440 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.440 |