sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2fje | FAD | Adenylylsulfate reductase, subunit A (AprA) |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2fje | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 1.000 | |
| 2fja | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.765 | |
| 1jnr | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.727 | |
| 1jnz | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.639 | |
| 2fjd | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.550 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.503 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.498 | |
| 3gb4 | D3M | DdmC | / | 0.498 | |
| 3lpf | Z77 | Beta-glucuronidase | 3.2.1.31 | 0.495 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.486 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.486 | |
| 2zsh | GA3 | Gibberellin receptor GID1A | 3 | 0.483 | |
| 1ikg | REX | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.480 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.480 | |
| 2fjb | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.480 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.480 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.480 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.478 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.476 | |
| 3arv | SAU | Chitinase A | / | 0.476 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.476 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.475 | |
| 3cnd | FAD | Polyamine oxidase FMS1 | / | 0.475 | |
| 3dge | ADP | Sensor histidine kinase | / | 0.475 | |
| 2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.474 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.474 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.474 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.474 | |
| 4a6e | ASE | Acetylserotonin O-methyltransferase | 2.1.1.4 | 0.474 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.474 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.473 | |
| 1kw6 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.472 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.472 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.471 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.470 | |
| 4biw | ANP | Sensor histidine kinase CpxA | / | 0.470 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.470 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.469 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.469 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.469 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.469 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.469 | |
| 4y1b | NAP | AntE | / | 0.469 | |
| 4xnw | 2ID | P2Y purinoceptor 1 | / | 0.469 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.468 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.468 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.468 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.468 | |
| 4isu | IKM | Glutamate receptor 2 | / | 0.468 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.467 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.467 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.466 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.466 | |
| 1c7o | PPG | Hemolysin | / | 0.465 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.465 | |
| 1til | ATP | Anti-sigma F factor | / | 0.465 | |
| 1zdw | FLV | Prenyltransferase | / | 0.465 | |
| 3ebl | GA4 | Gibberellin receptor GID1 | / | 0.465 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.465 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.464 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.464 | |
| 2b8j | ADN | Class B acid phosphatase | 3.1.3.2 | 0.464 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.464 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.464 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.464 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 1efa | NPF | Lactose operon repressor | / | 0.463 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 1r2j | FAD | FkbI | / | 0.463 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.463 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.463 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.463 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.463 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.463 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 4bdr | KAI | Glutamate receptor ionotropic, kainate 2 | / | 0.463 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.463 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.462 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.462 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.462 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.461 | |
| 2r2n | KYN | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.461 | |
| 2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.461 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.461 | |
| 4gki | 0JN | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.461 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.461 | |
| 4kxj | P34 | Nucleoprotein | / | 0.461 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.460 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.460 | |
| 2zsi | GA4 | Gibberellin receptor GID1A | 3 | 0.460 | |
| 1lrl | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.459 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.459 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.459 | |
| 3i28 | 34N | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.459 | |
| 4aos | NAP | Steroid monooxygenase | / | 0.459 | |
| 4b1i | A8P | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.459 | |
| 1lbb | KAI | Glutamate receptor 2 | / | 0.458 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.458 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase alpha chain | 1.13.11.3 | 0.458 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.458 | |
| 4fdn | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.458 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 1ix1 | BB2 | Peptide deformylase | / | 0.457 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.457 | |
| 2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.457 | |
| 3arp | DEQ | Chitinase A | / | 0.457 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.457 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.457 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.457 | |
| 3i12 | ADP | D-alanine--D-alanine ligase A | 6.3.2.4 | 0.457 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.457 | |
| 4gxs | 0YS | Glutamate receptor 2 | / | 0.457 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.457 | |
| 5czy | SAM | Eukaryotic huntingtin interacting protein B | / | 0.457 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.456 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.456 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2gou | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.456 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.456 | |
| 3sl2 | ATP | Sensor histidine kinase WalK | / | 0.456 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.456 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.456 | |
| 5eja | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.456 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.455 | |
| 1m8k | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.455 | |
| 1uhj | CZB | Aequorin-2 | / | 0.455 | |
| 2aj4 | ANP | Galactokinase | 2.7.1.6 | 0.455 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.455 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.455 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.455 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.455 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.455 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.455 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.455 | |
| 5dp2 | NAP | CurF | / | 0.455 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.454 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.454 | |
| 1nen | DNT | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.454 | |
| 1nen | DNT | Succinate dehydrogenase cytochrome b556 subunit | / | 0.454 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.454 | |
| 2v74 | SAH | Histone-arginine methyltransferase CARM1 | / | 0.454 | |
| 2zju | IM4 | Acetylcholine-binding protein | / | 0.454 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.454 | |
| 3fr4 | F8A | Fatty acid-binding protein, adipocyte | / | 0.454 | |
| 4aws | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.454 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.453 | |
| 1kmy | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.453 | |
| 1kqw | RTL | Cellular retinol-binding protein type II | / | 0.453 | |
| 1rp4 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.453 | |
| 1u0h | FOK | Adenylate cyclase type 2 | / | 0.453 | |
| 1u0h | FOK | Adenylate cyclase type 5 | / | 0.453 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.453 | |
| 2c9d | PHR | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.453 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.453 | |
| 3otq | MZL | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.453 | |
| 3q7f | ED2 | Uncharacterized protein | / | 0.453 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 4loc | BTN | Pyruvate carboxylase | / | 0.453 | |
| 1v45 | 3DG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.452 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.452 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.452 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.452 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.452 | |
| 4dk7 | 0KS | Oxysterols receptor LXR-beta | / | 0.452 | |
| 4dyp | 0MS | Nucleoprotein | / | 0.452 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 4gdp | FAD | Polyamine oxidase FMS1 | / | 0.452 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.452 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.451 | |
| 1t4c | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.451 | |
| 1x8v | ESL | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.451 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.451 | |
| 2b82 | ADN | Class B acid phosphatase | 3.1.3.2 | 0.451 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.451 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.451 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.451 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.451 | |
| 4qfy | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.451 | |
| 4mqt | 2CU | Muscarinic acetylcholine receptor M2 | / | 0.451 | |
| 1eio | GCH | Gastrotropin | / | 0.450 | |
| 1kh3 | ANP | Argininosuccinate synthase | / | 0.450 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.450 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.450 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.450 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.450 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.450 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.450 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 1kw8 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.449 | |
| 1u2g | APR | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.449 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.449 | |
| 1yvf | PH7 | Polyprotein | / | 0.449 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.449 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.449 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.449 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.449 | |
| 3b3f | SAH | Histone-arginine methyltransferase CARM1 | / | 0.449 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3dzi | RGT | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.449 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.449 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.449 | |
| 4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.449 | |
| 4kp7 | 1UQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.449 | |
| 4u0o | MTA | Lipoyl synthase 2 | / | 0.449 | |
| 4yaw | 2AM | NADPH--cytochrome P450 reductase | / | 0.449 | |
| 5iw5 | NMN | NADH pyrophosphatase | / | 0.449 | |
| 1bn3 | AL6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.448 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.448 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.448 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 2xb8 | XNW | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.448 | |
| 3bi5 | FAD | Polyamine oxidase FMS1 | / | 0.448 | |
| 3dhb | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.448 | |
| 3gc4 | AAQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.448 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.448 | |
| 3owj | 1EL | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.448 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.448 | |
| 1afs | TES | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.447 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.447 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.447 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.447 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.446 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.446 | |
| 1icu | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.446 | |
| 1if4 | FBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.446 | |
| 1okl | MNS | Carbonic anhydrase 2 | 4.2.1.1 | 0.446 | |
| 1s17 | GNR | Peptide deformylase | / | 0.446 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.446 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 2a2d | ANP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.446 | |
| 2iyp | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.446 | |
| 2xda | JPS | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.446 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.446 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.446 | |
| 2yej | XQK | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.446 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.446 | |
| 4b05 | 32D | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.446 | |
| 4fou | C2E | Uncharacterized protein | / | 0.446 | |
| 4hsh | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.446 | |
| 4ubv | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.446 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1amo | FMN | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 1bnw | TPD | Carbonic anhydrase 2 | 4.2.1.1 | 0.445 | |
| 1if8 | SBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.445 | |
| 1tys | DHF | Thymidylate synthase | / | 0.445 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.445 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.445 | |
| 2jfh | LK1 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.445 | |
| 2nn7 | M29 | Carbonic anhydrase 1 | 4.2.1.1 | 0.445 | |
| 2rdn | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.445 | |
| 3ec7 | NAD | Inositol 2-dehydrogenase | / | 0.445 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.445 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4g8b | HL6 | Alpha/beta hydrolase fold protein | / | 0.445 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.445 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.445 | |
| 4wbn | GTP | Tubulin alpha-1B chain | / | 0.445 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.445 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.445 | |
| 1dls | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1kw9 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.444 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.444 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.444 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2v2v | V12 | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.444 | |
| 2v3w | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.444 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.444 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.444 | |
| 3o9p | MHI | Periplasmic murein peptide-binding protein | / | 0.444 | |
| 4n1f | CZH | Obelin | / | 0.444 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.444 | |
| 1bnv | AL7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.443 | |
| 1upc | TPP | N(2)-(2-carboxyethyl)arginine synthase | / | 0.443 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.443 | |
| 1z5u | CMP | Class B acid phosphatase | / | 0.443 | |
| 2get | COK | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 3akm | 11D | Fatty acid-binding protein, intestinal | / | 0.443 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3vi5 | M4M | Hematopoietic prostaglandin D synthase | / | 0.443 | |
| 4a3u | FMN | NADH:flavin oxidoreductase/NADH oxidase | / | 0.443 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.443 | |
| 4o3m | ADP | Bloom syndrome protein | 3.6.4.12 | 0.443 | |
| 5jr3 | SAH | Carminomycin 4-O-methyltransferase DnrK | 2.1.1.292 | 0.443 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1i2c | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.442 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.442 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.442 | |
| 2fto | TMP | Thymidylate synthase | / | 0.442 | |
| 2hko | FAD | Lysine-specific histone demethylase 1A | 1 | 0.442 | |
| 2jla | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.442 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.442 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.442 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.442 | |
| 2vq7 | NAP | Putative flavin-containing monooxygenase | / | 0.442 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.442 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.442 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.442 | |
| 4nqg | CZH | Mitrocomin | / | 0.442 | |
| 4y9u | NAP | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 1a9c | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.441 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.441 | |
| 1jdz | FMB | Purine nucleoside phosphorylase | / | 0.441 | |
| 1knr | FAD | L-aspartate oxidase | 1.4.3.16 | 0.441 | |
| 1pl6 | 572 | Sorbitol dehydrogenase | 1.1.1.14 | 0.441 | |
| 1tys | TMP | Thymidylate synthase | / | 0.441 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2ipj | FFA | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
| 2jlc | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.441 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2weg | FBV | Carbonic anhydrase 2 | 4.2.1.1 | 0.441 | |
| 2x7j | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.441 | |
| 3c3e | FO1 | 2-phospho-L-lactate transferase | / | 0.441 | |
| 3e8x | NAP | BH1520 protein | / | 0.441 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.441 | |
| 3koz | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.441 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.441 | |
| 3qiz | QI2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.441 | |
| 3s8x | E59 | Carbonic anhydrase 2 | 4.2.1.1 | 0.441 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.441 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.441 | |
| 4azy | 7F3 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4f3g | KAI | Glutamate receptor 3 | / | 0.441 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 4itm | ATP | Tetraacyldisaccharide 4'-kinase | / | 0.441 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.441 | |
| 4s1i | PLP | Pyridoxal kinase, putative | / | 0.441 | |
| 4ztv | TA7 | Anthranilate phosphoribosyltransferase | / | 0.441 | |
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.441 | |
| 1bnm | AL8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.440 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.440 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1qs2 | NAD | Vip2Ac | / | 0.440 | |
| 1qv0 | CZH | Obelin | / | 0.440 | |
| 1y6o | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.440 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.440 | |
| 2eii | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.440 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.440 | |
| 2nom | DUT | Poly(A) polymerase, putative | / | 0.440 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 3q1k | ADP | D-alanine--D-alanine ligase A | 6.3.2.4 | 0.440 | |
| 3qj5 | 022 | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.440 | |
| 4biz | ADP | Sensor histidine kinase CpxA | / | 0.440 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4xba | 5GP | Aprataxin-like protein | 3 | 0.440 | |
| 5ej7 | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.440 |