sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4f1t | H52 | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4f1t | H52 | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 | 1.000 | |
| 4f1m | ACP | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 | 0.545 | |
| 4f0f | ACP | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 | 0.524 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 2rku | R78 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.515 | |
| 4f1o | ACP | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 | 0.513 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.512 | |
| 2og8 | 1N8 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.512 | |
| 2vz0 | D64 | Pteridine reductase | / | 0.509 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.508 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.505 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.504 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.504 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.500 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.500 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.499 | |
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.499 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.497 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.497 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.496 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.496 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.496 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.493 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.493 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.492 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.492 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.492 | |
| 2q2y | ADP | Kinesin-like protein KIF11 | / | 0.491 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.491 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.491 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.490 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.490 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.490 | |
| 3cth | 319 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.489 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.489 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.488 | |
| 3k45 | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 4hqv | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.488 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.488 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.487 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 1ozq | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.485 | |
| 2w5b | AGS | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.485 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.485 | |
| 4fc0 | 0T2 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.485 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.484 | |
| 1zy5 | ANP | eIF-2-alpha kinase GCN2 | / | 0.484 | |
| 3gi2 | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.483 | |
| 2fmn | 4HF | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.483 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.483 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.483 | |
| 4j52 | 1J3 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.483 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 2xk4 | OL2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.482 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.482 | |
| 4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.482 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.482 | |
| 1maq | PGU | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.481 | |
| 1rgs | CMP | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.481 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.481 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 3tub | FPU | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.481 | |
| 4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.480 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.480 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.480 | |
| 1kij | NOV | DNA gyrase subunit B | / | 0.479 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.479 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.479 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3eta | 351 | Insulin receptor | 2.7.10.1 | 0.479 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.479 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.479 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.478 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.478 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.478 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.477 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 3blo | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.476 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.476 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.476 | |
| 4z87 | GDP | Inosine-5'-monophosphate dehydrogenase | / | 0.476 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.475 | |
| 3oap | REA | Retinoic acid receptor RXR-alpha | / | 0.475 | |
| 4a99 | MIY | TetX family tetracycline inactivation enzyme | / | 0.475 | |
| 4lrr | CF9 | Thymidylate synthase | / | 0.475 | |
| 1ivr | CBA | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.474 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3p9t | TCL | Repressor | / | 0.474 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.474 | |
| 5hbs | RTL | Retinol-binding protein 1 | / | 0.474 | |
| 1djq | FMN | Trimethylamine dehydrogenase | 1.5.8.2 | 0.473 | |
| 2xk7 | 30E | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.473 | |
| 3iis | PID | Peridinin-chlorophyll a-binding protein 1, chloroplastic | / | 0.473 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.473 | |
| 1fgi | SU1 | Fibroblast growth factor receptor 1 | / | 0.472 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.472 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 4ap0 | ADP | Kinesin-like protein KIF11 | / | 0.472 | |
| 4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 2owb | 626 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.471 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.471 | |
| 4jln | 18V | Deoxycytidine kinase | 2.7.1.74 | 0.471 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.471 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.470 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3tky | N7I | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.470 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.470 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.470 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1t13 | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | / | 0.469 | |
| 2wpw | ACO | Orf14 | / | 0.469 | |
| 3d73 | NBB | Pheromone-binding protein ASP1 | / | 0.469 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.469 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.469 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1syn | F89 | Thymidylate synthase | / | 0.468 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.468 | |
| 2x20 | PID | Peridinin-chlorophyll a-binding protein 1, chloroplastic | / | 0.468 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.468 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.468 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 4a4x | JUP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.468 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.468 | |
| 4gki | 0JN | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.468 | |
| 4i5x | FLF | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.468 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.467 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.467 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.467 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.467 | |
| 2x9v | TMQ | Pteridine reductase | / | 0.467 | |
| 3er9 | 3AT | Poly(A) polymerase catalytic subunit | 2.7.7.19 | 0.467 | |
| 3ipq | 965 | Oxysterols receptor LXR-alpha | / | 0.467 | |
| 4hsh | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.467 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.466 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.466 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.466 | |
| 2xnp | WCX | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.466 | |
| 3dqw | AGS | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.466 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.466 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.466 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.465 | |
| 1zyd | ATP | eIF-2-alpha kinase GCN2 | / | 0.465 | |
| 2jdc | CAO | Probable acetyltransferase | / | 0.465 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.465 | |
| 4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.465 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.465 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.465 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
| 1u70 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1yrs | ADP | Kinesin-like protein KIF11 | / | 0.464 | |
| 2mm3 | CHO | Gastrotropin | / | 0.464 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.464 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.464 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.464 | |
| 3oia | A31 | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 3qj5 | 022 | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.464 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.464 | |
| 4iae | 1DX | Alr2278 protein | / | 0.464 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.464 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.464 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1r00 | SAH | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.463 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.463 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.463 | |
| 3drr | R8E | Gag-Pol polyprotein | 2.7.7.49 | 0.463 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.463 | |
| 1tsd | F89 | Thymidylate synthase | / | 0.462 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3l70 | JZV | Cytochrome b | / | 0.462 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 3vuf | ADP | Granule-bound starch synthase 1, chloroplastic/amyloplastic | 2.4.1.242 | 0.462 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 4h7z | GUN | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.462 | |
| 4pl9 | ADP | Ethylene receptor 1 | / | 0.462 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.462 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.461 | |
| 1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.461 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.461 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.461 | |
| 1rti | HEF | Gag-Pol polyprotein | 2.7.7.49 | 0.461 | |
| 1s2g | 3D1 | Nucleoside 2-deoxyribosyltransferase | / | 0.461 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1t48 | BB3 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.461 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.461 | |
| 2bxo | OPB | Serum albumin | / | 0.461 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.461 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.461 | |
| 3up0 | D7S | aceDAF-12 | / | 0.461 | |
| 4afe | GGY | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.461 | |
| 4c2w | ANP | Aurora kinase B-A | 2.7.11.1 | 0.461 | |
| 4h1j | 0YH | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.461 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 1ej3 | CZH | Aequorin-2 | / | 0.460 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.460 | |
| 3lm4 | HPX | Catechol 2,3-dioxygenase | / | 0.460 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.460 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.460 | |
| 4js9 | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.460 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.460 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.460 | |
| 1e2l | TMC | Thymidine kinase | / | 0.459 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1lwl | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 1ne6 | SP1 | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.459 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.459 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.459 | |
| 3of1 | CMP | cAMP-dependent protein kinase regulatory subunit | / | 0.459 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.459 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4dsb | A8S | Abscisic acid receptor PYL3 | / | 0.459 | |
| 4lsj | LSJ | Glucocorticoid receptor | / | 0.459 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.458 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.458 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.458 | |
| 2x21 | PID | Peridinin-chlorophyll a-binding protein 1, chloroplastic | / | 0.458 | |
| 3htj | ET | EbrA repressor | / | 0.458 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 3sl2 | ATP | Sensor histidine kinase WalK | / | 0.458 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
| 4dkb | DUN | Deoxyuridine triphosphatase, putative | / | 0.458 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.458 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 5ab7 | MLC | Nonspecific lipid-transfer protein, putative | / | 0.458 | |
| 5epe | SAH | Uncharacterized protein | / | 0.458 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.458 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.457 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.457 | |
| 2qx7 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.457 | |
| 2z1x | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.457 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 4agw | NG7 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.457 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.457 | |
| 4n4t | 2GV | Tankyrase-1 | 2.4.2.30 | 0.457 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.457 | |
| 5dst | SAH | Protein arginine N-methyltransferase 8 | 2.1.1 | 0.457 | |
| 2b01 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.456 | |
| 2c42 | TPP | Pyruvate synthase | / | 0.456 | |
| 2clh | F19 | Tryptophan synthase alpha chain | / | 0.456 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.456 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2z1w | BDI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.456 | |
| 3be2 | RAJ | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.456 | |
| 3bjh | NBB | Odorant binding protein ASP1 | / | 0.456 | |
| 3hxf | BD9 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.456 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 3thr | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.456 | |
| 3upy | FOM | Oxidoreductase, putative | / | 0.456 | |
| 4azw | SAM | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.456 | |
| 4kyk | IMN | Lactoylglutathione lyase | 4.4.1.5 | 0.456 | |
| 1map | KET | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.455 | |
| 1mzn | BM6 | Retinoic acid receptor RXR-alpha | / | 0.455 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.455 | |
| 1vkg | CRI | Histone deacetylase 8 | 3.5.1.98 | 0.455 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.455 | |
| 2c9e | PID | Peridinin-chlorophyll a protein, high-salt form | / | 0.455 | |
| 2pup | ADP | Methylthioribose kinase | 2.7.1.100 | 0.455 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
| 3n39 | FMN | Protein NrdI | / | 0.455 | |
| 4g1n | NZT | Pyruvate kinase PKM | 2.7.1.40 | 0.455 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.455 | |
| 4jqa | ID8 | Aldo-keto reductase family 1 member C2 | / | 0.455 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.454 | |
| 2vf0 | F89 | Thymidylate synthase | / | 0.454 | |
| 3cas | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.454 | |
| 3d74 | NBB | Pheromone-binding protein ASP1 | / | 0.454 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.454 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.454 | |
| 4ag7 | COA | Glucosamine 6-phosphate N-acetyltransferase | / | 0.454 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.454 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.454 | |
| 4hlh | 20D | Tankyrase-2 | 2.4.2.30 | 0.454 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4nh9 | 2LC | Endoplasmin | / | 0.454 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.454 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.454 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.454 | |
| 1dls | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1fcy | 564 | Retinoic acid receptor gamma | / | 0.453 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.453 | |
| 1y6r | MTM | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 3.2.2.9 | 0.453 | |
| 2hzq | STR | Apolipoprotein D | / | 0.453 | |
| 3ar7 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.453 | |
| 3qri | 919 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.453 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.453 | |
| 4iah | 1DX | Alr2278 protein | / | 0.453 | |
| 4ksp | 1SU | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.453 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.453 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1k4g | AIQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.452 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.452 | |
| 1ot3 | THM | Deoxynucleoside kinase | / | 0.452 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.452 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.452 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 2gm1 | ADP | Kinesin-like protein KIF11 | / | 0.452 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.452 | |
| 2r7n | ADP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase | / | 0.452 | |
| 2x2r | ADP | Kinesin-like protein KIF11 | / | 0.452 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.452 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 3t37 | FAD | Pyridoxine 4-oxidase | / | 0.452 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.452 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.452 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4gh1 | 0WX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.452 | |
| 4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.452 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.452 | |
| 4paa | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.452 | |
| 4phl | PIL | Phosphodiesterase | / | 0.452 | |
| 4y1b | NAP | AntE | / | 0.452 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 1f3e | DPZ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.451 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.451 | |
| 1nd5 | 2BF | Prostatic acid phosphatase | 3.1.3.2 | 0.451 | |
| 1r8q | AFB | Cytohesin-2 | / | 0.451 | |
| 1r8q | AFB | ADP-ribosylation factor 1 | / | 0.451 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.451 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.451 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.451 | |
| 3bmn | AX3 | Pteridine reductase | / | 0.451 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3jq6 | DX1 | Pteridine reductase, putative | / | 0.451 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.451 | |
| 3kxo | KXO | Hematopoietic prostaglandin D synthase | / | 0.451 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.451 | |
| 4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.451 | |
| 4jq3 | ZOM | Aldo-keto reductase family 1 member C2 | / | 0.451 | |
| 4mxe | ACO | N-acetyltransferase ESCO1 | 2.3.1 | 0.451 | |
| 4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.451 | |
| 1efz | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.450 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.450 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.450 | |
| 1u0w | STL | Chalcone synthase 2 | 2.3.1.74 | 0.450 | |
| 1zp4 | C2F | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.450 | |
| 2clf | F6F | Tryptophan synthase alpha chain | / | 0.450 | |
| 2gqf | FAD | Uncharacterized protein HI_0933 | / | 0.450 | |
| 2p4i | MR9 | Angiopoietin-1 receptor | 2.7.10.1 | 0.450 | |
| 2vi5 | Y19 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.450 | |
| 3bsy | ACO | UDP-N-acetylbacillosamine N-acetyltransferase | 2.3.1.203 | 0.450 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.450 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.450 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.450 | |
| 4kug | NAD | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.450 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.450 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.449 | |
| 1q4w | DQU | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.449 | |
| 1q63 | AIQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.449 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.449 | |
| 2ykv | IK2 | Beta-transaminase | / | 0.449 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.449 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.449 | |
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.449 | |
| 3tpt | ADP | Serine/threonine-protein kinase toxin HipA | / | 0.449 | |
| 4djx | 0KQ | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.449 | |
| 4k6i | 9RA | Retinoic acid receptor RXR-alpha | / | 0.449 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.449 | |
| 4utl | FNR | Xenobiotic reductase | / | 0.449 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.449 | |
| 4daj | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.449 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.448 | |
| 1hlk | 113 | Metallo-beta-lactamase type 2 | / | 0.448 | |
| 1rfq | LAR | Actin, alpha skeletal muscle | / | 0.448 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.448 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.448 | |
| 2cl5 | BIE | Catechol O-methyltransferase | 2.1.1.6 | 0.448 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.448 | |
| 2igx | A1T | Plasmepsin 2 | / | 0.448 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.448 | |
| 2vqb | NAP | Putative flavin-containing monooxygenase | / | 0.448 | |
| 2xae | ADP | Kinesin-like protein KIF11 | / | 0.448 | |
| 3b8q | 900 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.448 | |
| 3gie | ACP | Sensor histidine kinase DesK | 2.7.13.3 | 0.448 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.448 | |
| 3jq8 | DX3 | Pteridine reductase, putative | / | 0.448 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.448 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.448 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.448 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.448 | |
| 4u95 | MIY | Multidrug efflux pump subunit AcrB | / | 0.448 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.447 | |
| 1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1w83 | L11 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 2gfs | PQB | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.447 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.447 | |
| 3bmq | AX5 | Pteridine reductase | / | 0.447 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.447 | |
| 3jq7 | DX2 | Pteridine reductase, putative | / | 0.447 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 4a9e | 3PF | Bromodomain-containing protein 2 | / | 0.447 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.447 | |
| 4cid | ANP | EH domain-containing protein 2 | / | 0.447 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.447 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4m8h | R4M | Retinoic acid receptor RXR-alpha | / | 0.447 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.447 | |
| 5kf2 | COA | Predicted acetyltransferase | / | 0.447 | |
| 5dhg | DGV | Nociceptin receptor | / | 0.447 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1fby | REA | Retinoic acid receptor RXR-alpha | / | 0.446 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.446 | |
| 1std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.446 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2xnm | WGZ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.446 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.446 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.446 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.446 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.446 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.446 | |
| 3u3o | 3QV | Sulfotransferase 1A1 | 2.8.2.1 | 0.446 | |
| 3v0m | 5GW | Histo-blood group ABO system transferase | / | 0.446 | |
| 4a4l | 939 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.446 | |
| 4ajg | F07 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.446 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.446 | |
| 4g31 | 0WH | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.446 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.446 | |
| 4kw5 | 1W6 | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.446 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1ju6 | LYA | Thymidylate synthase | 2.1.1.45 | 0.445 | |
| 1k74 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.445 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.445 | |
| 1xiu | REA | Retinoic acid receptor RXR | / | 0.445 | |
| 2ati | IHU | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.445 | |
| 2oh4 | GIG | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.445 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.445 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 3q0g | BCO | Probable enoyl-CoA hydratase echA8 | 4.2.1.17 | 0.445 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.445 | |
| 4da6 | GA2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.445 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.445 | |
| 4gh3 | 0EV | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.445 | |
| 4gvs | F4M | Methenyltetrahydromethanopterin cyclohydrolase | 3.5.4.27 | 0.445 | |
| 4kao | KAO | Focal adhesion kinase 1 | 2.7.10.2 | 0.445 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.445 | |
| 4zhi | ADP | Kinesin-like protein KIF11 | / | 0.445 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.445 | |
| 1jtq | LY3 | Thymidylate synthase | / | 0.444 | |
| 1lud | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.444 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1p7t | ACO | Malate synthase G | / | 0.444 | |
| 1qzz | SAM | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.444 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.444 | |
| 2c3o | TPP | Pyruvate synthase | / | 0.444 | |
| 2d3a | ADP | Glutamine synthetase root isozyme 3 | 6.3.1.2 | 0.444 | |
| 2pjl | 047 | Steroid hormone receptor ERR1 | / | 0.444 | |
| 2qqf | A1R | NAD-dependent protein deacetylase HST2 | 3.5.1 | 0.444 | |
| 3a25 | SAM | tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase | / | 0.444 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.444 | |
| 3d77 | NBB | Pheromone-binding protein ASP1 | / | 0.444 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.444 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.444 | |
| 3x2f | NAI | Adenosylhomocysteinase | / | 0.444 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.444 | |
| 4bfr | J82 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 2.7.1.153 | 0.444 | |
| 4c2j | COA | 3-ketoacyl-CoA thiolase, mitochondrial | 2.3.1.16 | 0.444 | |
| 4c8b | 0LI | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.444 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.444 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.444 | |
| 4kyh | ZST | Lactoylglutathione lyase | 4.4.1.5 | 0.444 | |
| 4qii | 2NE | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.444 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.443 | |
| 1fd0 | 254 | Retinoic acid receptor gamma | / | 0.443 | |
| 1gt5 | BZQ | Odorant-binding protein | / | 0.443 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.443 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.443 | |
| 1sqp | MYX | Cytochrome b | / | 0.443 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2acw | UPG | Glycosyltransferase | / | 0.443 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.443 | |
| 2ewn | BTX | Bifunctional ligase/repressor BirA | / | 0.443 | |
| 2v57 | PRL | TetR family transcriptional regulator | / | 0.443 | |
| 2xkd | T3M | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.443 | |
| 2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.443 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.443 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3dmj | GWE | Pol protein | / | 0.443 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.443 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.443 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 3iex | GMP | Purine nucleoside phosphorylase | / | 0.443 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3rl4 | 5GP | Metallophosphoesterase MPPED2 | 3.1 | 0.443 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4qij | 1HA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.443 | |
| 1exa | 394 | Retinoic acid receptor gamma | / | 0.442 | |
| 1juj | LYA | Thymidylate synthase | 2.1.1.45 | 0.442 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1pwm | FID | Aldose reductase | 1.1.1.21 | 0.442 | |
| 1sqq | OST | Cytochrome b | / | 0.442 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 2b36 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2esd | NAP | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.9 | 0.442 | |
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.442 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 2p15 | EZT | Estrogen receptor | / | 0.442 | |
| 2wks | CB6 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.442 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3cse | N22 | Uncharacterized protein | / | 0.442 | |
| 3d2d | REN | Reticuline oxidase | 1.21.3.3 | 0.442 | |
| 3fzt | 4JZ | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.442 | |
| 3ngl | NAP | Bifunctional protein FolD | / | 0.442 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 3sgl | SAM | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | / | 0.442 | |
| 3w8z | HTK | Putative FAD-dependent oxygenase EncM | / | 0.442 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4hfp | 15U | Prothrombin | 3.4.21.5 | 0.442 | |
| 1bo4 | COA | Aminoglycoside-(3)-N-acetyltransferase | / | 0.441 | |
| 1it7 | GUN | tRNA-guanine(15) transglycosylase | 2.4.2.48 | 0.441 | |
| 1rp4 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.441 | |
| 1s6q | TPB | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 1xdk | REA | Retinoic acid receptor beta | / | 0.441 | |
| 1ybg | TAV | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.441 | |
| 2bfa | CB3 | Pteridine reductase 1 | 1.5.1.33 | 0.441 | |
| 2bxq | IMN | Serum albumin | / | 0.441 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.441 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.441 | |
| 2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 3c1x | CKK | Hepatocyte growth factor receptor | 2.7.10.1 | 0.441 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3e6y | CW1 | 14-3-3-like protein C | / | 0.441 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.441 | |
| 3n0y | APC | Adenylate cyclase 2 | / | 0.441 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.441 | |
| 3rql | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 3up3 | XCA | aceDAF-12 | / | 0.441 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.441 | |
| 4gab | FID | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.441 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4ug7 | H4B | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.441 | |
| 1bqo | N25 | Stromelysin-1 | 3.4.24.17 | 0.440 | |
| 1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1dtp | APU | Diphtheria toxin | / | 0.440 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.440 | |
| 1k4h | APQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 1l2o | ADP | Myosin heavy chain, striated muscle | / | 0.440 | |
| 1q1r | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.440 | |
| 1sjw | NGV | Nogalonic acid methyl ester cyclase | / | 0.440 | |
| 1yho | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2gsq | GBI | Glutathione S-transferase | 2.5.1.18 | 0.440 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.440 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.440 | |
| 2vcz | VC3 | Hematopoietic prostaglandin D synthase | / | 0.440 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 2y53 | NAP | 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase | / | 0.440 | |
| 2ydf | IO3 | Serum albumin | / | 0.440 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.440 | |
| 3n87 | N87 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.440 | |
| 3qpg | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.440 | |
| 3tdk | UPG | UDP-glucose 6-dehydrogenase | 1.1.1.22 | 0.440 | |
| 3w0t | HPU | Lactoylglutathione lyase | 4.4.1.5 | 0.440 | |
| 3wiy | LC6 | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.440 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4dlc | UMP | Deoxyuridine triphosphatase, putative | / | 0.440 | |
| 4gvq | N4M | Methenyltetrahydromethanopterin cyclohydrolase | 3.5.4.27 | 0.440 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.440 | |
| 4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.440 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.440 | |
| 5aqz | SGV | Heat shock 70 kDa protein 1A | / | 0.440 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.440 |