Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2pt6 | S4M | Spermidine synthase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2pt6 | S4M | Spermidine synthase | / | 1.000 | |
| 4yuv | S4M | Spermidine synthase, putative | / | 0.554 | |
| 4yv0 | S4M | Spermidine synthase, putative | / | 0.545 | |
| 4yv2 | S4M | Spermidine synthase, putative | / | 0.544 | |
| 4yuz | S4M | Spermidine synthase, putative | / | 0.518 | |
| 1i9g | SAM | tRNA (adenine(58)-N(1))-methyltransferase TrmI | / | 0.512 | |
| 4ntd | FAD | Thioredoxin reductase | / | 0.510 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.508 | |
| 2vo6 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.506 | |
| 3fwr | ADP | Transcriptional repressor CcpN | / | 0.501 | |
| 4fid | GDP | G protein alpha subunit, putative | / | 0.498 | |
| 4yv1 | S4M | Spermidine synthase, putative | / | 0.498 | |
| 3uax | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.496 | |
| 4ytn | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.493 | |
| 4de5 | 0JD | Pantothenate synthetase | 6.3.2.1 | 0.492 | |
| 1got | GDP | Guanine nucleotide-binding protein G(t) subunit alpha-1 | / | 0.491 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.489 | |
| 2vo7 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.488 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.487 | |
| 2y88 | 2ER | Phosphoribosyl isomerase A | 5.3.1.16 | 0.486 | |
| 1dq8 | COA | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.485 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.485 | |
| 3qvt | NAI | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.485 | |
| 4bva | T3 | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.483 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.482 | |
| 3k4c | FAD | Pyranose 2-oxidase | / | 0.482 | |
| 1wkh | PPE | [LysW]-aminoadipate semialdehyde transaminase | / | 0.481 | |
| 3c16 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.481 | |
| 1ijj | LAR | Actin, alpha skeletal muscle | / | 0.480 | |
| 1vrq | FMN | Subunit alpha of sarocosine oxidase | / | 0.479 | |
| 1vrq | FMN | Subunit beta of sarcosine oxidase | / | 0.479 | |
| 1xha | R68 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.479 | |
| 2uzu | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.479 | |
| 3gwd | FAD | Cyclohexanone monooxygenase | / | 0.479 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.478 | |
| 1ydr | IQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.478 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.478 | |
| 2v8p | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.477 | |
| 3lsm | SFD | Pyranose 2-oxidase | / | 0.476 | |
| 3zo4 | QWI | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.476 | |
| 3fpj | SAM | Uncharacterized protein | / | 0.475 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.475 | |
| 4uir | FAD | Oleate hydratase | 4.2.1.53 | 0.475 | |
| 1qf5 | RPL | Adenylosuccinate synthetase | / | 0.474 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.474 | |
| 3p8z | 36A | Genome polyprotein | 2.1.1.56 | 0.474 | |
| 4pd6 | URI | Nucleoside permease | / | 0.474 | |
| 2uzw | SS4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.473 | |
| 5f0a | 1FB | cGMP-dependent protein kinase, putative | / | 0.473 | |
| 1svh | I08 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.472 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.472 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.472 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.472 | |
| 3qvx | NAD | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.472 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.471 | |
| 1ovm | TPP | Indole-3-pyruvate decarboxylase | 4.1.1.74 | 0.471 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 1y3a | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.471 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.471 | |
| 1efa | NPF | Lactose operon repressor | / | 0.469 | |
| 1pfy | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.469 | |
| 2fon | FAD | Acyl-coenzyme A oxidase | / | 0.469 | |
| 2owu | SAH | Diphthine synthase | / | 0.469 | |
| 3fpz | AHZ | Thiamine thiazole synthase | / | 0.469 | |
| 3iph | G11 | Mitogen-activated protein kinase 14 | / | 0.469 | |
| 1l3i | SAH | Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) | / | 0.468 | |
| 1w4x | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.468 | |
| 2dki | FAD | 3-hydroxybenzoate 4-monooxygenase | 1.14.13.23 | 0.468 | |
| 3ckq | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.468 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.468 | |
| 5c2t | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.468 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3bxz | ADP | Protein translocase subunit SecA | / | 0.467 | |
| 3fpf | MTA | Uncharacterized protein | / | 0.467 | |
| 3sfe | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.467 | |
| 3zo1 | SIJ | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.467 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.467 | |
| 4poo | SAM | Putative RNA methylase | / | 0.467 | |
| 1gil | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.466 | |
| 2f7e | 2EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.466 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.466 | |
| 3jvv | ACP | Twitching mobility protein | / | 0.466 | |
| 3kyb | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.466 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.466 | |
| 3oog | YTP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.466 | |
| 4djh | JDC | Kappa-type opioid receptor | / | 0.466 | |
| 1gia | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.465 | |
| 1o94 | ADP | Trimethylamine dehydrogenase | 1.5.8.2 | 0.465 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1tj1 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.465 | |
| 2oh0 | 2PY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.465 | |
| 2plw | SAM | Ribosomal RNA methyltransferase, putative | / | 0.465 | |
| 3coz | 54H | Pantothenate synthetase | 6.3.2.1 | 0.465 | |
| 3uj8 | SFG | Phosphoethanolamine N-methyltransferase | / | 0.465 | |
| 4a0r | DTB | Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial | 6.3.3.3 | 0.465 | |
| 4ew2 | DXY | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.465 | |
| 5c3j | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.465 | |
| 5d1n | SAH | Uncharacterized protein | / | 0.465 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.464 | |
| 2ojf | 4PY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.464 | |
| 3fqk | 79Z | Genome polyprotein | 2.7.7.48 | 0.464 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.464 | |
| 4gn8 | ASO | Regucalcin | 3.1.1.17 | 0.464 | |
| 5fs7 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.464 | |
| 1kf6 | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.463 | |
| 1kia | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.463 | |
| 1rej | B1L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.463 | |
| 2jdt | I5S | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.463 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2wou | ZZF | TGF-beta receptor type-1 | 2.7.11.30 | 0.463 | |
| 2x8i | X8I | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.463 | |
| 3m0o | FAD | Monomeric sarcosine oxidase | 1.5.3.1 | 0.463 | |
| 4opl | FDA | Conserved Archaeal protein | / | 0.463 | |
| 5b0o | ADP | Flagellum-specific ATP synthase | 3.6.3.14 | 0.463 | |
| 1d4c | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.462 | |
| 1m75 | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.462 | |
| 2e0a | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.462 | |
| 3bbt | FMM | Receptor tyrosine-protein kinase erbB-4 | 2.7.10.1 | 0.462 | |
| 3fkl | FKL | Mitogen-activated protein kinase 14 | / | 0.462 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.462 | |
| 4ajo | 88N | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.462 | |
| 4ftk | H9K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 4kiq | 1RA | Mitogen-activated protein kinase 14 | / | 0.462 | |
| 4riy | ANP | Receptor tyrosine-protein kinase erbB-3 | 2.7.10.1 | 0.462 | |
| 4xvu | ATP | ATPase GET3 | / | 0.462 | |
| 2gnh | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.461 | |
| 3vqh | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.461 | |
| 4f65 | 0S9 | Fibroblast growth factor receptor 1 | / | 0.461 | |
| 4jl5 | ADP | Adenylate kinase | / | 0.461 | |
| 4mwz | SAM | Phosphoethanolamine N-methyltransferase, putative | / | 0.461 | |
| 4qx5 | CMP | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.461 | |
| 1pzg | A3D | Lactate dehydrogenase | / | 0.460 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.460 | |
| 3fsk | RO6 | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 3lff | Z83 | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 3mb7 | 14I | Casein kinase II subunit alpha | 2.7.11.1 | 0.460 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.460 | |
| 4x9n | FAD | Uncharacterized protein MG039 homolog | / | 0.460 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.459 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.459 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.459 | |
| 3ums | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.459 | |
| 4kz0 | 1UJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 1d4d | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.458 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.458 | |
| 1hbv | GAN | Gag-Pol polyprotein | / | 0.458 | |
| 2g82 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.458 | |
| 2o06 | MTA | Spermidine synthase | 2.5.1.16 | 0.458 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.458 | |
| 2z6u | SAH | Modification methylase HhaI | 2.1.1.37 | 0.458 | |
| 3q8h | AO9 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.458 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.458 | |
| 4a4q | UX9 | Pol protein | / | 0.458 | |
| 4fko | 20K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1c3e | GAR | Phosphoribosylglycinamide formyltransferase | / | 0.457 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.457 | |
| 1i6x | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.457 | |
| 1pzf | A3D | Lactate dehydrogenase | / | 0.457 | |
| 2hjr | APR | Malate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase | / | 0.457 | |
| 2ii4 | COA | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial | 2.3.1.168 | 0.457 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.457 | |
| 3wt0 | ATP | Cell division protein FtsA | / | 0.457 | |
| 4ctk | SAM | Genome polyprotein | / | 0.457 | |
| 1i6k | TYM | Tryptophan--tRNA ligase | 6.1.1.2 | 0.456 | |
| 2ejj | SAH | Diphthine synthase | / | 0.456 | |
| 2uzh | CDP | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.456 | |
| 3fg2 | FAD | Putative rubredoxin reductase | / | 0.456 | |
| 3lby | SAH | Uncharacterized protein | / | 0.456 | |
| 1azt | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.455 | |
| 1lon | IMO | Adenylosuccinate synthetase isozyme 1 | / | 0.455 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.455 | |
| 1pr5 | TBN | Purine nucleoside phosphorylase DeoD-type | / | 0.455 | |
| 1sve | I01 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.455 | |
| 2qmy | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.455 | |
| 2ylx | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.455 | |
| 2z54 | AB1 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 3bgr | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.455 | |
| 4al4 | W7E | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.455 | |
| 4f4q | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.455 | |
| 4s1h | ADP | Pyridoxal kinase, putative | / | 0.455 | |
| 1djq | ADP | Trimethylamine dehydrogenase | 1.5.8.2 | 0.454 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.454 | |
| 1m76 | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.454 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.454 | |
| 1qo8 | FAD | Fumarate reductase flavoprotein subunit | / | 0.454 | |
| 2hxl | 422 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.454 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.454 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 3uay | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.454 | |
| 4ajp | 88N | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.454 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.454 | |
| 4i4z | 2NE | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.454 | |
| 1dss | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.453 | |
| 1pr0 | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.453 | |
| 1q1w | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.453 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.453 | |
| 2w06 | FRV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 3cls | FAD | Electron transfer flavoprotein subunit alpha | / | 0.453 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.453 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.453 | |
| 4yjd | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.453 | |
| 5bsg | NAP | Pyrroline-5-carboxylate reductase | / | 0.453 | |
| 5icf | SAH | (S)-norcoclaurine 6-O-methyltransferase | / | 0.453 | |
| 1ea0 | FMN | Glutamate synthase [NADPH] large chain | 1.4.1.13 | 0.452 | |
| 1f0x | FAD | D-lactate dehydrogenase | 1.1.1.28 | 0.452 | |
| 1k6v | XN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 2b5o | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.452 | |
| 2ejz | SAH | Diphthine synthase | / | 0.452 | |
| 2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 2pci | SAH | Diphthine synthase | / | 0.452 | |
| 3e2s | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.452 | |
| 3ime | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.452 | |
| 3qvp | FAD | Glucose oxidase | 1.1.3.4 | 0.452 | |
| 3uaw | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.452 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.452 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.452 | |
| 4lsm | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.452 | |
| 1bw9 | NAD | Phenylalanine dehydrogenase | / | 0.451 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.451 | |
| 1q8w | M77 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.451 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.451 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.451 | |
| 2rc4 | ACO | Histone acetyltransferase KAT6A | / | 0.451 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.451 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.451 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3dbv | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.451 | |
| 3e8n | VRA | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.451 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.451 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3ts1 | TYA | Tyrosine--tRNA ligase | 6.1.1.1 | 0.451 | |
| 5bpf | ADP | D-alanine--D-alanine ligase | / | 0.451 | |
| 1qf4 | RPD | Adenylosuccinate synthetase | / | 0.450 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.450 | |
| 2bpw | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 2e4n | SAH | Diphthine synthase | / | 0.450 | |
| 2fjb | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.450 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.450 | |
| 3bwj | ARX | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.450 | |
| 3onw | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.450 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.450 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.450 | |
| 4i52 | 1HA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.450 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.450 | |
| 4kos | 4KO | Uncharacterized protein | / | 0.450 | |
| 4xrg | NAD | Homospermidine synthase | 2.5.1.44 | 0.450 | |
| 1cul | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.449 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 1q8u | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.449 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.449 | |
| 2nyu | SAM | rRNA methyltransferase 2, mitochondrial | / | 0.449 | |
| 3cin | NAD | Myo-inositol-1-phosphate synthase-related protein | / | 0.449 | |
| 3juh | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.449 | |
| 3l9h | EMQ | Kinesin-like protein KIF11 | / | 0.449 | |
| 3lzw | FAD | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.449 | |
| 3ryh | GTP | Tubulin alpha chain | / | 0.449 | |
| 3vye | VYE | Renin | 3.4.23.15 | 0.449 | |
| 4ctj | SAM | Genome polyprotein | / | 0.449 | |
| 4ehz | JAK | Tyrosine-protein kinase JAK1 | / | 0.449 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4imp | NDP | Polyketide synthase extender modules 3-4 | / | 0.449 | |
| 4iv0 | SAM | Phosphoethanolamine N-methyltransferase, putative | / | 0.449 | |
| 4j5r | A1R | O-acetyl-ADP-ribose deacetylase 1 | 3.5.1 | 0.449 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.449 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.449 | |
| 4xnh | ACO | N-terminal acetyltransferase A complex subunit NAT5 | 2.3.1 | 0.449 | |
| 5cx6 | CDP | RNA-dependent RNA polymerase | / | 0.449 | |
| 5dn1 | AMZ | Phosphoribosyl isomerase A | 5.3.1.16 | 0.449 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.449 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2ejk | SAH | Diphthine synthase | / | 0.448 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
| 3b8z | 294 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.448 | |
| 3cgd | FAD | Coenzyme A disulfide reductase | / | 0.448 | |
| 3coy | 53H | Pantothenate synthetase | 6.3.2.1 | 0.448 | |
| 3pfi | ADP | Holliday junction ATP-dependent DNA helicase RuvB | / | 0.448 | |
| 4aos | FAD | Steroid monooxygenase | / | 0.448 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.448 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.448 | |
| 4l3j | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.448 | |
| 4mok | FAD | Pyranose 2-oxidase | / | 0.448 | |
| 1mzs | 669 | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | / | 0.447 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.447 | |
| 1pxl | CK4 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.447 | |
| 2dgn | DOI | Adenylosuccinate synthetase isozyme 1 | / | 0.447 | |
| 2e77 | FMN | Lactate oxidase | / | 0.447 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.447 | |
| 2j5b | TYE | Tyrosine--tRNA ligase | 6.1.1.1 | 0.447 | |
| 2p5c | SAH | Diphthine synthase | / | 0.447 | |
| 2yr5 | FAD | Phenylalanine 2-monooxygenase precursor | 1.13.12.9 | 0.447 | |
| 3cos | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.447 | |
| 3ely | SAH | Methyltransferase | / | 0.447 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.447 | |
| 3l9l | L9L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 3lmg | ANP | Receptor tyrosine-protein kinase erbB-3 | 2.7.10.1 | 0.447 | |
| 3n6m | GTP | Genome polyprotein | / | 0.447 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4emt | C2E | Stimulator of interferon genes protein | / | 0.447 | |
| 4idv | 13V | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.447 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.447 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.447 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.446 | |
| 1rfq | LAR | Actin, alpha skeletal muscle | / | 0.446 | |
| 1u33 | LM2 | Pancreatic alpha-amylase | / | 0.446 | |
| 1xzq | FON | tRNA modification GTPase MnmE | 3.6.5 | 0.446 | |
| 2hmv | ADP | Ktr system potassium uptake protein A | / | 0.446 | |
| 2ien | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 2owk | SAH | Diphthine synthase | / | 0.446 | |
| 2p41 | SAH | Genome polyprotein | / | 0.446 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2zfn | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.446 | |
| 3cge | FAD | Coenzyme A disulfide reductase | / | 0.446 | |
| 3mpt | 1GK | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.446 | |
| 3ow3 | SMY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 3tx1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.446 | |
| 4a8m | ATP | RNA-directed RNA polymerase | 2.7.7.48 | 0.446 | |
| 4c0b | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.446 | |
| 4loq | SB4 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.445 | |
| 1i75 | NOJ | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.445 | |
| 1m0b | 0ZQ | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1xh6 | R94 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 2b69 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.445 | |
| 2gv8 | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.445 | |
| 2uw5 | GVN | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 2x0q | ATP | Alcaligin biosynthesis protein | / | 0.445 | |
| 3ivg | FG5 | Pantothenate synthetase | 6.3.2.1 | 0.445 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.445 | |
| 3mte | SAM | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.445 | |
| 3t7s | SAM | Uncharacterized protein | / | 0.445 | |
| 3t88 | S0N | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.445 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.445 | |
| 4biw | ANP | Sensor histidine kinase CpxA | / | 0.445 | |
| 4c36 | ZO9 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 4el5 | D1M | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.445 | |
| 4rcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.445 | |
| 4s1i | PLP | Pyridoxal kinase, putative | / | 0.445 | |
| 4xd1 | T3Q | Qdtf | / | 0.445 | |
| 5dqr | FAD | 7-hydroxymethyl chlorophyll a reductase, chloroplastic | 1.17.7.2 | 0.445 | |
| 1djn | ADP | Trimethylamine dehydrogenase | 1.5.8.2 | 0.444 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1iy8 | NAD | Levodione reductase | / | 0.444 | |
| 1j0x | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.444 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.444 | |
| 1lqu | NDP | NADPH-ferredoxin reductase FprA | 1.18.1.2 | 0.444 | |
| 1nv8 | SAM | Release factor glutamine methyltransferase | 2.1.1.297 | 0.444 | |
| 1sow | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.444 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.444 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.444 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3tog | 079 | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4a9u | A9U | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.444 | |
| 4lz8 | 1YX | Glutamate receptor 2 | / | 0.444 | |
| 4mk0 | 29X | Beta-adrenergic receptor kinase 1 | 2.7.11.15 | 0.444 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.444 | |
| 4ng5 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.444 | |
| 4p13 | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.444 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1kqg | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.443 | |
| 1la2 | NAD | Inositol-3-phosphate synthase | 5.5.1.4 | 0.443 | |
| 1okk | GCP | Signal recognition particle protein | / | 0.443 | |
| 1okk | GCP | Signal recognition particle receptor FtsY | / | 0.443 | |
| 1vik | BAY | Gag-Pol polyprotein | / | 0.443 | |
| 1x7d | NAD | Putative ornithine cyclodeaminase | / | 0.443 | |
| 1xh4 | R69 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.443 | |
| 2f7z | 6EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 2prz | OMP | Orotate phosphoribosyltransferase 1 | 2.4.2.10 | 0.443 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.443 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.443 | |
| 3go4 | SAH | Uncharacterized protein | / | 0.443 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.443 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.443 | |
| 3pgi | F41 | Endothiapepsin | 3.4.23.22 | 0.443 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.443 | |
| 3rai | X85 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4i02 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.443 | |
| 4i9n | 1E5 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.443 | |
| 5er0 | FAD | Uncharacterized NAD(FAD)-dependent dehydrogenase | / | 0.443 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.442 | |
| 1vso | AT1 | Glutamate receptor ionotropic, kainate 1 | / | 0.442 | |
| 2b4y | APR | NAD-dependent protein deacylase sirtuin-5, mitochondrial | / | 0.442 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.442 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.442 | |
| 2gfs | PQB | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 2gnl | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 2ooy | ATP | 5'-AMP-activated protein kinase subunit gamma | / | 0.442 | |
| 2ore | SAH | DNA adenine methylase | 2.1.1.72 | 0.442 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.442 | |
| 2qo6 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.442 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.442 | |
| 3dgh | FAD | Thioredoxin reductase 1, mitochondrial | 1.8.1.9 | 0.442 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.442 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.442 | |
| 3pwm | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3ua8 | 08W | Glutamate receptor 2 | / | 0.442 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 4p5f | AR6 | Inosine-uridine nucleoside N-ribohydrolase | / | 0.442 | |
| 5jjr | SAH | Genome polyprotein | / | 0.442 | |
| 1eag | A70 | Candidapepsin-2 | 3.4.23.24 | 0.441 | |
| 1mei | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.441 | |
| 2bts | U32 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 2ivf | MGD | Alpha-subunit of ethylbenzene dehydrogenase | / | 0.441 | |
| 2jah | NDP | Clavaldehyde dehydrogenase | / | 0.441 | |
| 2tmd | ADP | Trimethylamine dehydrogenase | 1.5.8.2 | 0.441 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.441 | |
| 2v52 | LAB | Actin, alpha skeletal muscle | / | 0.441 | |
| 3ix3 | OHN | Transcriptional activator protein LasR | / | 0.441 | |
| 3upr | 1KX | HLA class I histocompatibility antigen, B-57 alpha chain | / | 0.441 | |
| 4axa | RKD | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4do3 | 0LA | Fatty-acid amide hydrolase 1 | 3.5.1.99 | 0.441 | |
| 4e32 | DWN | Methyltransferase | / | 0.441 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.441 | |
| 4kb9 | G79 | Protease | / | 0.441 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 5f2k | SAH | Uncharacterized protein | / | 0.441 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.441 | |
| 5k0s | 0OU | Methionine--tRNA ligase | / | 0.441 | |
| 5l3r | GCP | Cell division protein FtsY homolog, chloroplastic | / | 0.441 | |
| 1c0l | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.440 | |
| 1k08 | BZD | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.440 | |
| 1ryi | FAD | Glycine oxidase | 1.4.3.19 | 0.440 | |
| 1sny | NAP | LD36273p | / | 0.440 | |
| 1w1r | ZEA | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.440 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.440 | |
| 2b8t | THM | Thymidine kinase | / | 0.440 | |
| 2c0o | L2G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.440 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.440 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.440 | |
| 2p9h | IPT | Lactose operon repressor | / | 0.440 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.440 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3dnd | LL2 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 3e6e | DCS | Alanine racemase | / | 0.440 | |
| 3q9t | FAY | Uncharacterized protein | / | 0.440 | |
| 3wbb | NAP | Meso-diaminopimelate D-dehydrogenase | / | 0.440 | |
| 4aa5 | NQB | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4f9b | 0SY | Cell division cycle 7-related protein kinase | 2.7.11.1 | 0.440 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.440 | |
| 4hia | FMN | LOV protein | / | 0.440 | |
| 4m10 | ICD | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.440 | |
| 4oa5 | SAH | O-methyltransferase family protein | / | 0.440 | |
| 4s26 | SAH | Phosphomethylpyrimidine synthase, chloroplastic | 4.1.99.17 | 0.440 | |
| 4yqf | GDP | Septin-9 | / | 0.440 |